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Rik Derynck - Publications

Affiliations: 
Cell and Tissue Biology University of California, San Francisco, San Francisco, CA 
Area:
Signal transduction, Cancer research, TGF-beta
Website:
http://irm.ucsf.edu/derynck/

201 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Moses HL, Roberts AB, Derynck R. The Discovery and Early Days of TGF-β: A Historical Perspective. Cold Spring Harbor Perspectives in Biology. PMID 27328871 DOI: 10.1101/Cshperspect.A021865  0.32
2016 Budi EH, Xu J, Derynck R. Regulation of TGF-β Receptors. Methods in Molecular Biology (Clifton, N.J.). 1344: 1-33. PMID 26520115 DOI: 10.1007/978-1-4939-2966-5_1  0.32
2015 Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R. ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation. Plos Biology. 13: e1002325. PMID 26680585 DOI: 10.1371/Journal.Pbio.1002325  0.32
2015 Budi EH, Muthusamy BP, Derynck R. The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors. Science Signaling. 8: ra96. PMID 26420907 DOI: 10.1126/Scisignal.Aaa9432  0.32
2014 Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling. Molecular Cell. 56: 723-37. PMID 25526531 DOI: 10.1016/J.Molcel.2014.11.027  0.32
2014 Derynck R, Muthusamy BP, Saeteurn KY. Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition. Current Opinion in Cell Biology. 31: 56-66. PMID 25240174 DOI: 10.1016/J.Ceb.2014.09.001  0.32
2014 Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. Journal of Immunology (Baltimore, Md. : 1950). 192: 2939-52. PMID 24659787  0.32
2014 Xu J, Derynck R. Does Smad6 methylation control BMP signaling in cancer? Cell Cycle (Georgetown, Tex.). 13: 1209-10. PMID 24621505 DOI: 10.4161/Cc.28380  0.32
2014 Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology. 15: 178-96. PMID 24556840 DOI: 10.1038/Nrm3758  0.32
2013 Derynck R, Akhurst RJ. BMP-9 balances endothelial cell fate. Proceedings of the National Academy of Sciences of the United States of America. 110: 18746-7. PMID 24222686 DOI: 10.1073/Pnas.1318346110  0.32
2013 Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. Arginine Methylation Initiates BMP-Induced Smad Signaling. Molecular Cell. 51: 5-19. PMID 23747011 DOI: 10.1016/J.Molcel.2013.05.004  0.32
2013 Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. The Journal of Biological Chemistry. 288: 18546-60. PMID 23649632 DOI: 10.1074/Jbc.M112.446591  0.32
2013 Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Current Opinion in Cell Biology. 25: 200-7. PMID 23434068 DOI: 10.1016/J.Ceb.2013.01.008  0.32
2013 Katsuno Y, Lamouille S, Derynck R. TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Current Opinion in Oncology. 25: 76-84. PMID 23197193 DOI: 10.1097/Cco.0B013E32835B6371  0.32
2013 Sakaki-Yumoto M, Katsuno Y, Derynck R. TGF-β family signaling in stem cells. Biochimica Et Biophysica Acta. 1830: 2280-96. PMID 22959078 DOI: 10.1016/J.Bbagen.2012.08.008  0.32
2012 Xu P, Liu J, Derynck R. Post-translational regulation of TGF-β receptor and Smad signaling. Febs Letters. 586: 1871-84. PMID 22617150 DOI: 10.1016/J.Febslet.2012.05.010  0.32
2012 Xu P, Liu J, Sakaki-Yumoto M, Derynck R. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Science Signaling. 5: ra34. PMID 22550340 DOI: 10.1126/Scisignal.2002689  0.32
2012 Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. Journal of Cell Science. 125: 1259-73. PMID 22399812 DOI: 10.1242/Jcs.095299  0.32
2011 Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 7820-5. PMID 21518866 DOI: 10.1073/Pnas.1103441108  0.32
2011 Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nature Biotechnology. 29: 443-8. PMID 21490602 DOI: 10.1038/Nbt.1862  0.32
2011 Lamouille S, Derynck R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition. Cells, Tissues, Organs. 193: 8-22. PMID 21041997 DOI: 10.1159/000320172  0.32
2010 Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, et al. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. Embo Reports. 11: 765-71. PMID 20847738 DOI: 10.1038/Embor.2010.135  0.32
2010 Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Molecular Cell. 37: 551-66. PMID 20188673 DOI: 10.1016/J.Molcel.2010.01.034  0.32
2009 Lamouille S, Derynck R. Oncogene and tumour suppressor: the two faces of SnoN. The Embo Journal. 28: 3459-60. PMID 19920850 DOI: 10.1038/Emboj.2009.311  0.32
2009 Wharton K, Derynck R. TGFbeta family signaling: novel insights in development and disease. Development (Cambridge, England). 136: 3691-7. PMID 19855012 DOI: 10.1242/Dev.040584  0.32
2009 Piscopo DM, Johansen EB, Derynck R. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. The Journal of Biological Chemistry. 284: 31690-703. PMID 19759027 DOI: 10.1074/Jbc.M109.052316  0.32
2009 Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends in Cell Biology. 19: 385-94. PMID 19648010 DOI: 10.1016/J.Tcb.2009.05.008  0.32
2009 Wu L, Derynck R. Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Developmental Cell. 17: 35-48. PMID 19619490 DOI: 10.1016/J.Devcel.2009.05.010  0.32
2009 Liu C, Xu P, Lamouille S, Xu J, Derynck R. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Molecular Cell. 35: 26-36. PMID 19595713 DOI: 10.1016/J.Molcel.2009.06.018  0.32
2009 Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, ... Derynck R, et al. Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. Plos One. 4: e5275. PMID 19357790 DOI: 10.1371/Journal.Pone.0005275  0.32
2009 Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Research. 19: 156-72. PMID 19153598 DOI: 10.1038/Cr.2009.5  0.32
2009 Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. The Embo Journal. 28: 88-98. PMID 19096363 DOI: 10.1038/Emboj.2008.266  0.32
2008 Imhof I, Gasper WJ, Derynck R. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. Journal of Cell Science. 121: 2265-74. PMID 18544636 DOI: 10.1242/Jcs.021717  0.32
2008 Kang JS, Saunier EF, Akhurst RJ, Derynck R. The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nature Cell Biology. 10: 654-64. PMID 18469808 DOI: 10.1038/Ncb1728  0.32
2007 Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nature Cell Biology. 9: 1000-4. PMID 17762890 DOI: 10.1038/Ncb434  0.32
2007 Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. The Embo Journal. 26: 3957-67. PMID 17673906 DOI: 10.1038/Sj.Emboj.7601818  0.32
2007 Lamouille S, Derynck R. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. The Journal of Cell Biology. 178: 437-51. PMID 17646396 DOI: 10.1083/Jcb.200611146  0.32
2007 Castro CP, Piscopo D, Nakagawa T, Derynck R. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. Journal of Cell Science. 120: 2454-66. PMID 17607000 DOI: 10.1242/Jcs.004200  0.32
2006 Wan DC, Aalami OO, Wang Z, Nacamuli RP, Lorget F, Derynck R, Longaker MT. Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plastic and Reconstructive Surgery. 118: 851-61. PMID 16980845 DOI: 10.1097/01.Prs.0000232366.23897.2B  0.32
2006 Habig M, Smola H, Dole VS, Derynck R, Pfister H, Smola-Hess S. E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated Smad proteins and inhibit their transcriptional activity. Archives of Virology. 151: 1961-72. PMID 16710631 DOI: 10.1007/s00705-006-0768-1  0.32
2005 Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGF-beta regulates the mechanical properties and composition of bone matrix. Proceedings of the National Academy of Sciences of the United States of America. 102: 18813-8. PMID 16354837 DOI: 10.1073/Pnas.0507417102  0.32
2005 Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annual Review of Cell and Developmental Biology. 21: 659-93. PMID 16212511 DOI: 10.1146/Annurev.Cellbio.21.022404.142018  0.32
2005 Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science (New York, N.Y.). 310: 68-71. PMID 16210527 DOI: 10.1126/Science.1118389  0.32
2005 Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 in complex with CBP. Structure (London, England : 1993). 13: 1269-77. PMID 16154084 DOI: 10.1016/J.Str.2005.06.011  0.32
2005 Kang JS, Alliston T, Delston R, Derynck R. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. The Embo Journal. 24: 2543-55. PMID 15990875 DOI: 10.1038/Sj.Emboj.7600729  0.32
2005 Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 233: 1315-31. PMID 15965977 DOI: 10.1002/Dvdy.20450  0.32
2005 Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. The Journal of Biological Chemistry. 280: 24227-37. PMID 15849193 DOI: 10.1074/Jbc.M414305200  0.32
2004 Pardoux C, Derynck R. JNK regulates expression and autocrine signaling of TGF-beta1. Molecular Cell. 15: 170-1. PMID 15260968 DOI: 10.1016/J.Molcel.2004.07.001  0.32
2004 Liu D, Kang JS, Derynck R. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. The Embo Journal. 23: 1557-66. PMID 15044954 DOI: 10.1038/Sj.Emboj.7600179  0.32
2004 Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Molecular and Cellular Biology. 24: 1411-25. PMID 14729983 DOI: 10.1128/Mcb.24.3.1411-1425.2004  0.32
2003 Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nature Structural Biology. 10: 913-21. PMID 14555996 DOI: 10.1038/Nsb1002  0.32
2003 Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425: 577-84. PMID 14534577 DOI: 10.1038/Nature02006  0.32
2003 Lee PS, Chang C, Liu D, Derynck R. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. The Journal of Biological Chemistry. 278: 27853-63. PMID 12740389 DOI: 10.1074/Jbc.M301755200  0.32
2003 Fan H, Turck CW, Derynck R. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. The Journal of Biological Chemistry. 278: 18617-27. PMID 12621058 DOI: 10.1074/jbc.M300331200  0.32
2003 Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. The Journal of Biological Chemistry. 278: 9609-19. PMID 12524424 DOI: 10.1074/Jbc.M212259200  0.32
2002 Skillington J, Choy L, Derynck R. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. The Journal of Cell Biology. 159: 135-46. PMID 12379805 DOI: 10.1083/Jcb.200204060  0.32
2002 Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. The Journal of Biological Chemistry. 277: 38399-408. PMID 12161428 DOI: 10.1074/jbc.M203188200  0.32
2002 Alliston T, Derynck R. Medicine: interfering with bone remodelling. Nature. 416: 686-7. PMID 11961535 DOI: 10.1038/416686A  0.32
2001 Roberts AB, Derynck R. Meeting report: signaling schemes for TGF-beta. Science's Stke : Signal Transduction Knowledge Environment. 2001: pe43. PMID 11752631 DOI: 10.1126/Stke.2001.113.Pe43  0.32
2001 Liu D, Black BL, Derynck R. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes & Development. 15: 2950-66. PMID 11711431 DOI: 10.1101/Gad.925901  0.32
2001 Akhurst RJ, Derynck R. TGF-beta signaling in cancer--a double-edged sword. Trends in Cell Biology. 11: S44-51. PMID 11684442 DOI: 10.1016/S0962-8924(01)02130-4  0.32
2001 Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nature Genetics. 29: 117-29. PMID 11586292 DOI: 10.1038/Ng1001-117  0.32
2001 Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia (New York, N.Y.). 3: 339-50. PMID 11571634 DOI: 10.1038/Sj.Neo.7900170  0.32
2001 Feng XH, Derynck R. Mammalian two-hybrid assays. Analyzing protein-protein interactions in transforming growth factor-beta signaling pathway. Methods in Molecular Biology (Clifton, N.J.). 177: 221-39. PMID 11530609 DOI: 10.1385/1-59259-210-4:221  0.32
2001 Alliston T, Choy L, Ducy P, Karsenty G, Derynck R. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. The Embo Journal. 20: 2254-72. PMID 11331591 DOI: 10.1093/Emboj/20.9.2254  0.32
2001 Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 98: 974-9. PMID 11158580 DOI: 10.1073/Pnas.98.3.974  0.32
2000 Kuo A, Zhong C, Lane WS, Derynck R. Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55. The Embo Journal. 19: 6427-39. PMID 11101516 DOI: 10.1093/Emboj/19.23.6427  0.32
2000 Feng XH, Lin X, Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. The Embo Journal. 19: 5178-93. PMID 11013220 DOI: 10.1093/Emboj/19.19.5178  0.32
2000 Patil S, Wildey GM, Brown TL, Choy L, Derynck R, Howe PH. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. The Journal of Biological Chemistry. 275: 38363-70. PMID 10995749 DOI: 10.1074/Jbc.M004861200  0.32
2000 Qing J, Zhang Y, Derynck R. Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. The Journal of Biological Chemistry. 275: 38802-12. PMID 10995748 DOI: 10.1074/Jbc.M004731200  0.32
2000 Choy L, Skillington J, Derynck R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. The Journal of Cell Biology. 149: 667-82. PMID 10791980 DOI: 10.1083/Jcb.149.3.667  0.32
2000 Zhang Y, Derynck R. Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members. The Journal of Biological Chemistry. 275: 16979-85. PMID 10748032 DOI: 10.1074/Jbc.M001526200  0.32
2000 Shi W, Fan H, Shum L, Derynck R. The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation. The Journal of Cell Biology. 148: 591-602. PMID 10662783 DOI: 10.1083/Jcb.148.3.591  0.32
1999 Fan H, Derynck R. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. The Embo Journal. 18: 6962-72. PMID 10601018 DOI: 10.1093/Emboj/18.24.6962  0.32
1999 Derynck R. Skeletal development in the zebrafish. Nature Genetics. 23: 379. PMID 10581014 DOI: 10.1038/70474  0.32
1999 Kornblum HI, Zurcher SD, Werb Z, Derynck R, Seroogy KB. Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system. The European Journal of Neuroscience. 11: 3236-46. PMID 10510187 DOI: 10.1046/J.1460-9568.1999.00744.X  0.32
1999 Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development (Cambridge, England). 126: 4267-79. PMID 10477295  0.32
1999 Zhang Y, Derynck R. Regulation of Smad signalling by protein associations and signalling crosstalk. Trends in Cell Biology. 9: 274-9. PMID 10370243 DOI: 10.1016/S0962-8924(99)01579-2  0.32
1999 Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler CF, Derynck R, Werb Z. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nature Genetics. 22: 69-73. PMID 10319864 DOI: 10.1038/8773  0.32
1998 Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell. 95: 737-40. PMID 9865691 DOI: 10.1016/S0092-8674(00)81696-7  0.32
1998 Choy L, Derynck R. The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response. The Journal of Biological Chemistry. 273: 31455-62. PMID 9813058 DOI: 10.1074/Jbc.273.47.31455  0.32
1998 Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R. Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. Molecular and Cellular Biology. 18: 6595-604. PMID 9774674 DOI: 10.1128/Mcb.18.11.6595  0.32
1998 Filvaroff E, Derynck R. Bone remodelling: a signalling system for osteoclast regulation. Current Biology : Cb. 8: R679-82. PMID 9768352 DOI: 10.1016/S0960-9822(98)70434-8  0.32
1998 Kornblum HI, Hussain R, Wiesen J, Miettinen P, Zurcher SD, Chow K, Derynck R, Werb Z. Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor. Journal of Neuroscience Research. 53: 697-717. PMID 9753198 DOI: 10.1002/(Sici)1097-4547(19980915)53:6<697::Aid-Jnr8>3.0.Co;2-0  0.32
1998 Sebastian J, Richards RG, Walker MP, Wiesen JF, Werb Z, Derynck R, Hom YK, Cunha GR, DiAugustine RP. Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 777-85. PMID 9751121  0.32
1998 Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 394: 909-13. PMID 9732876 DOI: 10.1038/29814  0.32
1998 Feng XH, Zhang Y, Wu RY, Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes & Development. 12: 2153-63. PMID 9679060 DOI: 10.1101/Gad.12.14.2153  0.32
1998 Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. Osteoblastic responses to TGF-beta during bone remodeling. Molecular Biology of the Cell. 9: 1903-18. PMID 9658179 DOI: 10.1091/Mbc.9.7.1903  0.32
1998 Derynck R. SMAD proteins and mammalian anatomy. Nature. 393: 737-9. PMID 9655387 DOI: 10.1038/31593  0.32
1998 Gorska AE, Joseph H, Derynck R, Moses HL, Serra R. Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 229-38. PMID 9543389  0.32
1998 Hom YK, Young P, Wiesen JF, Miettinen PJ, Derynck R, Werb Z, Cunha GR. Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. Endocrinology. 139: 913-21. PMID 9492020 DOI: 10.1210/Endo.139.3.5817  0.32
1998 Zhang Y, Feng X, Derynck R. Encouraging education and outreach initiatives Nature. 396: 493. DOI: 10.1038/24918  0.32
1997 Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development (Cambridge, England). 124: 4467-80. PMID 9409665  0.32
1997 Derynck R, Feng XH. TGF-beta receptor signaling. Biochimica Et Biophysica Acta. 1333: F105-50. PMID 9395284 DOI: 10.1016/S0304-419X(97)00017-6  0.32
1997 Verlhac MH, Chen RH, Hanachi P, Hershey JW, Derynck R. Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation. The Embo Journal. 16: 6812-22. PMID 9362495 DOI: 10.1093/Emboj/16.22.6812  0.32
1997 Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. The Journal of Cell Biology. 139: 541-52. PMID 9334355 DOI: 10.1083/Jcb.139.2.541  0.32
1997 Feng XH, Derynck R. A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. The Embo Journal. 16: 3912-23. PMID 9233801 DOI: 10.1093/Emboj/16.13.3912  0.32
1997 Miettinen PJ, Warburton D, Bu D, Zhao JS, Berger JE, Minoo P, Koivisto T, Allen L, Dobbs L, Werb Z, Derynck R. Impaired lung branching morphogenesis in the absence of functional EGF receptor. Developmental Biology. 186: 224-36. PMID 9205141 DOI: 10.1006/Dbio.1997.8593  0.32
1997 Lawler S, Feng XH, Chen RH, Maruoka EM, Turck CW, Griswold-Prenner I, Derynck R. The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. The Journal of Biological Chemistry. 272: 14850-9. PMID 9169454 DOI: 10.1074/jbc.272.23.14850  0.32
1997 Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR. Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. Proceedings of the National Academy of Sciences of the United States of America. 94: 2386-91. PMID 9122204 DOI: 10.1073/Pnas.94.6.2386  0.32
1997 Wu RY, Zhang Y, Feng XH, Derynck R. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Molecular and Cellular Biology. 17: 2521-8. PMID 9111321 DOI: 10.1128/Mcb.17.5.2521  0.32
1997 Zhang Y, Musci T, Derynck R. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Current Biology : Cb. 7: 270-6. PMID 9094310 DOI: 10.1016/S0960-9822(06)00123-0  0.32
1997 Gitelman SE, Kobrin M, Lee A, Fet V, Lyons K, Hogan BL, Derynck R. Structure and sequence of the mouse Bmp6 gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 212-4. PMID 9069123 DOI: 10.1007/S003359900391  0.32
1997 Hanachi P, Vornlocher HP, Verchac MH, Derynck R, Hershey JWB. Cloning and characterization of the 33 kilodalton subunit of yeast translation initiation factor eIF3 Faseb Journal. 11: A1402.  0.32
1996 Derynck R, Zhang Y. Intracellular signalling: the mad way to do it. Current Biology : Cb. 6: 1226-9. PMID 8939556 DOI: 10.1016/S0960-9822(96)00702-6  0.32
1996 Shum L, Turck CW, Derynck R. Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. The Journal of Biological Chemistry. 271: 28502-8. PMID 8910478 DOI: 10.1074/Jbc.271.45.28502  0.32
1996 Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF. Nomenclature: vertebrate mediators of TGFbeta family signals. Cell. 87: 173. PMID 8861901 DOI: 10.1016/S0092-8674(00)81335-5  0.32
1996 Filvaroff EH, Derynck R. Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation. Developmental Biology. 178: 459-71. PMID 8812142 DOI: 10.1006/Dbio.1996.0231  0.32
1996 Zhang Y, Feng X, We R, Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 383: 168-72. PMID 8774881 DOI: 10.1038/383168A0  0.32
1996 Feng XH, Derynck R. Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. The Journal of Biological Chemistry. 271: 13123-9. PMID 8662796 DOI: 10.1074/Jbc.271.22.13123  0.32
1996 Erlebacher A, Derynck R. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. The Journal of Cell Biology. 132: 195-210. PMID 8567723 DOI: 10.1083/Jcb.132.1.195  0.32
1995 Derynck R, Wagner EF. Cell differentiation. Current Opinion in Cell Biology. 7: 843-4. PMID 8791397  0.32
1995 Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. Toward a molecular understanding of skeletal development. Cell. 80: 371-8. PMID 7859279 DOI: 10.1016/0092-8674(95)90487-5  0.32
1995 Chen RH, Moses HL, Maruoka EM, Derynck R, Kawabata M. Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors. The Journal of Biological Chemistry. 270: 12235-41. PMID 7744874 DOI: 10.1074/Jbc.270.20.12235  0.32
1995 Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 376: 337-41. PMID 7630400 DOI: 10.1038/376337A0  0.32
1995 Feng XH, Filvaroff EH, Derynck R. Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. The Journal of Biological Chemistry. 270: 24237-45. PMID 7592630 DOI: 10.1074/Jbc.270.41.24237  0.32
1995 Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. Nature. 377: 548-52. PMID 7566156 DOI: 10.1038/377548A0  0.32
1995 Gitelman SE, Kirk M, Ye JQ, Filvaroff EH, Kahn AJ, Derynck R. Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 6: 827-36. PMID 7547504  0.32
1994 Derynck R, Chen RH, Ebner R, Filvaroff EH, Lawler S. An emerging complexity of receptors for transforming growth factor-beta. Princess Takamatsu Symposia. 24: 264-75. PMID 8983081  0.32
1994 Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R. Association of the transmembrane TGF-alpha precursor with a protein kinase complex. The Journal of Cell Biology. 125: 903-16. PMID 8188754 DOI: 10.1083/Jcb.125.4.903  0.32
1994 Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R. The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. Development (Cambridge, England). 120: 165-75. PMID 8119124  0.32
1994 Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA. Transforming growth factor-beta activation in irradiated murine mammary gland. The Journal of Clinical Investigation. 93: 892-9. PMID 8113421 DOI: 10.1172/Jci117045  0.32
1994 Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. The Journal of Cell Biology. 126: 1595-609. PMID 8089189 DOI: 10.1083/Jcb.126.6.1595  0.32
1994 Filvaroff EH, Ebner R, Derynck R. Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor. Development (Cambridge, England). 120: 1085-95. PMID 8026322  0.32
1994 Derynck R. TGF-beta-receptor-mediated signaling. Trends in Biochemical Sciences. 19: 548-53. PMID 7846768 DOI: 10.1016/0968-0004(94)90059-0  0.32
1994 Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. The Journal of Cell Biology. 127: 2021-36. PMID 7806579 DOI: 10.1083/Jcb.127.6.2021  0.32
1994 Chen RH, Derynck R. Homomeric interactions between type II transforming growth factor-beta receptors. The Journal of Biological Chemistry. 269: 22868-74. PMID 7521335  0.32
1993 Streuli CH, Schmidhauser C, Kobrin M, Bissell MJ, Derynck R. Extracellular matrix regulates expression of the TGF-beta 1 gene. The Journal of Cell Biology. 120: 253-60. PMID 8416992 DOI: 10.1083/Jcb.120.1.253  0.32
1993 Ebner R, Chen RH, Shum L, Lawler S, Zioncheck TF, Lee A, Lopez AR, Derynck R. Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science (New York, N.Y.). 260: 1344-8. PMID 8388127 DOI: 10.1126/Science.8388127  0.32
1993 Chen RH, Ebner R, Derynck R. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. Science (New York, N.Y.). 260: 1335-8. PMID 8388126 DOI: 10.1126/Science.8388126  0.32
1993 Gazit D, Ebner R, Kahn AJ, Derynck R. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Molecular Endocrinology (Baltimore, Md.). 7: 189-98. PMID 8385738 DOI: 10.1210/Mend.7.2.8385738  0.32
1993 Pittelkow MR, Cook PW, Shipley GD, Derynck R, Coffey RJ. Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 4: 513-21. PMID 8373735  0.32
1993 Chang HL, Gillett N, Figari I, Lopez AR, Palladino MA, Derynck R. Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Research. 53: 4391-8. PMID 8364935  0.32
1993 Nabel EG, Shum L, Pompili VJ, Yang ZY, San H, Shu HB, Liptay S, Gold L, Gordon D, Derynck R. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proceedings of the National Academy of Sciences of the United States of America. 90: 10759-63. PMID 8248168 DOI: 10.1073/Pnas.90.22.10759  0.32
1993 Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R. Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science (New York, N.Y.). 262: 900-2. PMID 8235612 DOI: 10.1126/Science.8235612  0.32
1992 Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1. The Journal of Cell Biology. 118: 715-26. PMID 1639853 DOI: 10.1083/Jcb.118.3.715  0.32
1992 Lopez AR, Cook J, Deininger PL, Derynck R. Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms. Molecular and Cellular Biology. 12: 1674-9. PMID 1549120 DOI: 10.1128/Mcb.12.4.1674  0.32
1992 Derynck R. The physiology of transforming growth factor-alpha. Advances in Cancer Research. 58: 27-52. PMID 1546559 DOI: 10.1016/S0065-230X(08)60289-4  0.32
1992 Arrick BA, Derynck R. Growth regulation by transforming growth factor-beta. Cancer Treatment and Research. 63: 255-64. PMID 1363360 DOI: 10.1007/978-1-4615-3088-6_12  0.32
1991 Arrick BA, Lee AL, Grendell RL, Derynck R. Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region. Molecular and Cellular Biology. 11: 4306-13. PMID 1875922 DOI: 10.1128/Mcb.11.9.4306  0.32
1991 Balentien E, Mufson BE, Shattuck RL, Derynck R, Richmond A. Effects of MGSA/GRO alpha on melanocyte transformation. Oncogene. 6: 1115-24. PMID 1861861  0.32
1991 Thomas HG, Han JH, Balentien E, Derynck R, Bordoni R, Richmond A. Purification and characterization of recombinant melanoma growth stimulating activity. Methods in Enzymology. 198: 373-83. PMID 1857230 DOI: 10.1016/0076-6879(91)98038-8  0.32
1991 Lucas C, Bringman TS, Derynck R. Generation of antibodies and assays for transforming growth factor alpha. Methods in Enzymology. 198: 185-91. PMID 1857217 DOI: 10.1016/0076-6879(91)98019-3  0.32
1991 Ebner R, Derynck R. Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regulation. 2: 599-612. PMID 1777504 DOI: 10.1091/Mbc.2.8.599  0.32
1991 Lyons RM, Miller DA, Graycar JL, Moses HL, Derynck R. Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors. Molecular Endocrinology (Baltimore, Md.). 5: 1887-96. PMID 1665203 DOI: 10.1210/Mend-5-12-1887  0.32
1991 Ebner R, Derynck R. Epidermal growth factor and transforming growth factor-α: Differential intracellular routing and processing of ligand-receptor complexes Molecular Biology of the Cell. 2: 599-612.  0.32
1990 Miller DA, Pelton RW, Derynck R, Moses HL. Transforming growth factor-beta. A family of growth regulatory peptides. Annals of the New York Academy of Sciences. 593: 208-17. PMID 2375595 DOI: 10.1111/J.1749-6632.1990.Tb16113.X  0.32
1990 Arrick BA, Korc M, Derynck R. Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol. Cancer Research. 50: 299-303. PMID 2295070  0.32
1990 Derynck R, Balentien E, Han JH, Greg Thomas H, Wen D, Samantha AK, Zachariae CO, Griffin PR, Brachmann R, Wong WL, Matsushima K, Richmond A. Recombinant expression, biochemical characterization, and biological activities of the human MGSA/gro protein Biochemistry®. 29: 10225-10233. PMID 2271650  0.32
1990 Derynck R. Transforming growth factor-alpha. Molecular Reproduction and Development. 27: 3-9. PMID 2271184 DOI: 10.1002/Mrd.1080270104  0.32
1990 Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S. Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 145: 940-4. PMID 2115549  0.32
1990 Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM. Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics. 6: 505-20. PMID 1970330 DOI: 10.1016/0888-7543(90)90480-I  0.32
1989 Pittelkow MR, Lindquist PB, Abraham RT, Graves-Deal R, Derynck R, Coffey RJ. Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters. The Journal of Biological Chemistry. 264: 5164-71. PMID 2925687  0.32
1989 Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. The Journal of Biological Chemistry. 264: 4133-7. PMID 2917992  0.32
1989 Elder JT, Fisher GJ, Lindquist PB, Bennett GL, Pittelkow MR, Coffey RJ, Ellingsworth L, Derynck R, Voorhees JJ. Overexpression of transforming growth factor alpha in psoriatic epidermis. Science (New York, N.Y.). 243: 811-4. PMID 2916128 DOI: 10.1126/Science.2916128  0.32
1989 Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R. Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos. Molecular Endocrinology (Baltimore, Md.). 3: 1108-14. PMID 2797004 DOI: 10.1210/Mend-3-7-1108  0.32
1989 Shankar V, Ciardiello F, Kim N, Derynck R, Liscia DS, Merlo G, Langton BC, Sheer D, Callahan R, Bassin RH. Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA. Molecular Carcinogenesis. 2: 1-11. PMID 2786419 DOI: 10.1002/Mc.2940020102  0.32
1989 Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BL, Derynck R. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proceedings of the National Academy of Sciences of the United States of America. 86: 4554-8. PMID 2734307 DOI: 10.1073/Pnas.86.12.4554  0.32
1989 Wen DZ, Rowland A, Derynck R. Expression and secretion of gro/MGSA by stimulated human endothelial cells. The Embo Journal. 8: 1761-6. PMID 2670560 DOI: 10.1002/J.1460-2075.1989.Tb03569.X  0.32
1989 Brachmann R, Lindquist PB, Nagashima M, Kohr W, Lipari T, Napier M, Derynck R. Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell. 56: 691-700. PMID 2645058 DOI: 10.1016/0092-8674(89)90591-6  0.32
1989 Graycar JL, Miller DA, Arrick BA, Lyons RM, Moses HL, Derynck R. Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2. Molecular Endocrinology (Baltimore, Md.). 3: 1977-86. PMID 2628733 DOI: 10.1210/Mend-3-12-1977  0.32
1989 Miller DA, Lee A, Matsui Y, Chen EY, Moses HL, Derynck R. Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. Molecular Endocrinology (Baltimore, Md.). 3: 1926-34. PMID 2628730 DOI: 10.1210/Mend-3-12-1926  0.32
1989 Bascom CC, Wolfshohl JR, Coffey RJ, Madisen L, Webb NR, Purchio AR, Derynck R, Moses HL. Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Molecular and Cellular Biology. 9: 5508-15. PMID 2586525 DOI: 10.1128/Mcb.9.12.5508  0.32
1989 Derynck R. Transforming growth factors-alpha and -beta and their potential roles in neoplastic transformation. Cancer Treatment and Research. 47: 177-95. PMID 2576997 DOI: 10.1007/978-1-4613-1599-5_8  0.32
1988 Barton DE, Foellmer BE, Du J, Tamm J, Derynck R, Francke U. Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Research. 3: 323-31. PMID 3226728  0.32
1988 Wilcox JN, Derynck R. Developmental expression of transforming growth factors alpha and beta in mouse fetus. Molecular and Cellular Biology. 8: 3415-22. PMID 3211146 DOI: 10.1128/Mcb.8.8.3415  0.32
1988 Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ. A new type of transforming growth factor-beta, TGF-beta 3. The Embo Journal. 7: 3737-43. PMID 3208746 DOI: 10.1002/J.1460-2075.1988.Tb03257.X  0.32
1988 Derynck R. Transforming growth factor alpha. Cell. 54: 593-5. PMID 3044605 DOI: 10.1016/S0092-8674(88)80001-1  0.32
1988 Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. The Embo Journal. 7: 2025-33. PMID 2970963 DOI: 10.1002/J.1460-2075.1988.Tb03042.X  0.32
1988 Jakobovits EB, Schlokat U, Vannice JL, Derynck R, Levinson AD. The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. Molecular and Cellular Biology. 8: 5549-54. PMID 2907605 DOI: 10.1128/Mcb.8.12.5549  0.32
1988 Finzi E, Kilkenny A, Strickland JE, Balaschak M, Bringman T, Derynck R, Aaronson S, Yuspa SH. TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. Molecular Carcinogenesis. 1: 7-12. PMID 2475136 DOI: 10.1002/Mc.2940010105  0.32
1988 Wilcox JN, Derynck R. Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 1901-4. PMID 2455024 DOI: 10.1523/Jneurosci.08-06-01901.1988  0.32
1987 Gutierrez GE, Mundy GR, Derynck R, Hewlett EL, Katz MS. Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. The Journal of Biological Chemistry. 262: 15845-50. PMID 3500168  0.32
1987 Smith JJ, Derynck R, Korc M. Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle. Proceedings of the National Academy of Sciences of the United States of America. 84: 7567-70. PMID 3499610 DOI: 10.1073/Pnas.84.21.7567  0.32
1987 Gan BS, Hollenberg MD, MacCannell KL, Lederis K, Winkler ME, Derynck R. Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. The Journal of Pharmacology and Experimental Therapeutics. 242: 331-7. PMID 3497258  0.32
1987 Salomon DS, Perroteau I, Kidwell WR, Tam J, Derynck R. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. Journal of Cellular Physiology. 130: 397-409. PMID 3494020 DOI: 10.1002/Jcp.1041300313  0.32
1987 Derynck R, Rhee L, Chen EY, Van Tilburg A. Intron-exon structure of the human transforming growth factor-beta precursor gene. Nucleic Acids Research. 15: 3188-9. PMID 3470709 DOI: 10.1093/Nar/15.7.3188  0.32
1987 Derynck R, Rhee L. Sequence of the porcine transforming growth factor-beta precursor. Nucleic Acids Research. 15: 3187. PMID 3470708 DOI: 10.1093/Nar/15.7.3187  0.32
1987 Bringman TS, Lindquist PB, Derynck R. Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor. Cell. 48: 429-40. PMID 3467848 DOI: 10.1016/0092-8674(87)90194-2  0.32
1987 Derynck R, Goeddel DV, Ullrich A, Gutterman JU, Williams RD, Bringman TS, Berger WH. Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Research. 47: 707-12. PMID 3467839  0.32
1987 Finzi E, Fleming T, Segatto O, Pennington CY, Bringman TS, Derynck R, Aaronson SA. The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 3733-7. PMID 3035551 DOI: 10.1073/Pnas.84.11.3733  0.32
1987 Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R, Dickson RB. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell. 48: 417-28. PMID 2879636 DOI: 10.1016/0092-8674(87)90193-0  0.32
1987 Liu SC, Sanfilippo B, Perroteau I, Derynck R, Salomon DS, Kidwell WR. Expression of transforming growth factor alpha (TGF alpha) in differentiated rat mammary tumors: estrogen induction of TGF alpha production. Molecular Endocrinology (Baltimore, Md.). 1: 683-92. PMID 2484711 DOI: 10.1210/Mend-1-10-683  0.32
1987 Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR. Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature. 328: 817-20. PMID 2442615 DOI: 10.1038/328817A0  0.32
1986 Haegeman G, Content J, Volckaert G, Derynck R, Tavernier J, Fiers W. Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. European Journal of Biochemistry / Febs. 159: 625-32. PMID 3758081 DOI: 10.1111/J.1432-1033.1986.Tb09931.X  0.32
1986 Derynck R. Transforming growth factor-alpha: structure and biological activities. Journal of Cellular Biochemistry. 32: 293-304. PMID 3543030 DOI: 10.1002/Jcb.240320406  0.32
1986 Tashjian AH, Voelkel EF, Lloyd W, Derynck R, Winkler ME, Levine L. Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice. The Journal of Clinical Investigation. 78: 1405-9. PMID 3490496 DOI: 10.1172/Jci112728  0.32
1986 Takahashi N, MacDonald BR, Hon J, Winkler ME, Derynck R, Mundy GR, Roodman GD. Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures. The Journal of Clinical Investigation. 78: 894-8. PMID 3489738 DOI: 10.1172/Jci112677  0.32
1986 Ibbotson KJ, Harrod J, Gowen M, D'Souza S, Smith DD, Winkler ME, Derynck R, Mundy GR. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 83: 2228-32. PMID 3485799 DOI: 10.1073/Pnas.83.7.2228  0.32
1986 Derynck R, Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV. Endogenous and heterologous expression of transforming growth factor-alpha in mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 51: 649-55. PMID 3472744 DOI: 10.1101/Sqb.1986.051.01.077  0.32
1986 Fujii D, Brissenden JE, Derynck R, Francke U. Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somatic Cell and Molecular Genetics. 12: 281-8. PMID 3459257 DOI: 10.1007/Bf01570787  0.32
1986 Derynck R, Jarrett JA, Chen EY, Goeddel DV. The murine transforming growth factor-beta precursor. The Journal of Biological Chemistry. 261: 4377-9. PMID 3007454  0.32
1986 Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. The Journal of Experimental Medicine. 163: 1037-50. PMID 2871125 DOI: 10.1084/Jem.163.5.1037  0.32
1986 Schreiber AB, Winkler ME, Derynck R. Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science (New York, N.Y.). 232: 1250-3. PMID 2422759 DOI: 10.1126/Science.2422759  0.32
1985 Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. Human transforming growth factor-alpha stimulates bone resorption in vitro. The Journal of Clinical Investigation. 76: 2016-9. PMID 3877079 DOI: 10.1172/Jci112202  0.32
1985 Smith JM, Sporn MB, Roberts AB, Derynck R, Winkler ME, Gregory H. Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. Nature. 315: 515-6. PMID 3873618 DOI: 10.1038/315515A0  0.32
1985 Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. 316: 701-5. PMID 3861940 DOI: 10.1038/316701A0  0.32
1985 Tashjian AH, Voelkel EF, Lazzaro M, Singer FR, Roberts AB, Derynck R, Winkler ME, Levine L. Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proceedings of the National Academy of Sciences of the United States of America. 82: 4535-8. PMID 3859875 DOI: 10.1073/Pnas.82.13.4535  0.32
1984 Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV. Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell. 38: 287-97. PMID 6088071 DOI: 10.1016/0092-8674(84)90550-6  0.32
1982 Derynck R, Leung DW, Gray PW, Goeddel DV. Human interferon gamma is encoded by a single class of mRNA. Nucleic Acids Research. 10: 3605-15. PMID 6180381 DOI: 10.1093/Nar/10.12.3605  0.32
1982 Gray PW, Leung DW, Pennica D, Yelverton E, Najarian R, Simonsen CC, Derynck R, Sherwood PJ, Wallace DM, Berger SL, Levinson AD, Goeddel DV. Expression of human immune interferon cDNA in E. coli and monkey cells. Nature. 295: 503-8. PMID 6173769 DOI: 10.1038/295503A0  0.32
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