| Year |
Citation |
Score |
| 2019 |
Perry CK, Casey AB, Felsing DE, Vemula R, Zaka M, Herrington NB, Cui M, Kellogg GE, Canal CE, Booth RG. Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT and 5-HT G protein-coupled receptor affinity, 3D-QSAR and molecular modeling. Bioorganic & Medicinal Chemistry. 115262. PMID 31882369 DOI: 10.1016/J.Bmc.2019.115262 |
0.354 |
|
| 2019 |
Felsing DE, Canal CE, Booth RG. Ligand-directed serotonin 5-HT receptor desensitization, β-arrestin recruitment, and sensitization. European Journal of Pharmacology. PMID 30689993 DOI: 10.1016/J.Ejphar.2019.01.037 |
0.359 |
|
| 2017 |
Casey AB, Canal CE. Classics in Chemical Neuroscience: Aripiprazole. Acs Chemical Neuroscience. PMID 28368577 DOI: 10.1021/acschemneuro.7b00087 |
0.309 |
|
| 2016 |
Canal CE, Murnane KS. The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens. Journal of Psychopharmacology (Oxford, England). PMID 27903793 DOI: 10.1177/0269881116677104 |
0.309 |
|
| 2016 |
Liu Y, Canal CE, Cordova-Sintjago TC, Zhu W, Booth RG. Mutagenesis analysis reveals distinct amino acids of the human serotonin 5-HT2C receptor underlie the pharmacology of distinct ligands. Acs Chemical Neuroscience. PMID 27580242 DOI: 10.1021/Acschemneuro.6B00124 |
0.321 |
|
| 2015 |
Canal CE, Felsing DE, Liu Y, Zhu W, Wood JT, Perry CK, Vemula R, Booth RG. Correction to An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models. Acs Chemical Neuroscience. PMID 26225542 DOI: 10.1021/Acschemneuro.5B00197 |
0.332 |
|
| 2015 |
Canal CE, Felsing DE, Liu Y, Zhu W, Wood JT, Perry CK, Vemula R, Booth RG. An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models. Acs Chemical Neuroscience. PMID 26011730 DOI: 10.1021/Acschemneuro.5B00099 |
0.367 |
|
| 2015 |
Sakhuja R, Kondabolu K, Córdova-Sintjago T, Travers S, Vincek AS, Kim MS, Abboud KA, Fang L, Sun Z, Canal CE, Booth RG. Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors. Bioorganic & Medicinal Chemistry. 23: 1588-600. PMID 25703249 DOI: 10.1016/J.Bmc.2015.01.060 |
0.347 |
|
| 2014 |
Canal CE, Morgan D, Felsing D, Kondabolu K, Rowland NE, Robertson KL, Sakhuja R, Booth RG. A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses. The Journal of Pharmacology and Experimental Therapeutics. 349: 310-8. PMID 24563531 DOI: 10.1124/Jpet.113.212373 |
0.353 |
|
| 2014 |
Canal CE, Morgan D, Felsing D, Kondabolu K, Rowland NE, Robertson KL, Sakhuja R, Booth RG. Erratum: A novel aminotetralin-type serotonin (5-HT)2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses (Journal of Pharmacology and Experimental Therapeutics (2014) 349 (310-318) DOI:10.1124/jpet.113.212373) Journal of Pharmacology and Experimental Therapeutics. 349. DOI: 10.1124/Jpet.114.06Er14 |
0.368 |
|
| 2013 |
Canal CE, Cordova-Sintjago T, Liu Y, Kim MS, Morgan D, Booth RG. Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands. The Journal of Pharmacology and Experimental Therapeutics. 347: 705-16. PMID 24080681 DOI: 10.1124/Jpet.113.208637 |
0.334 |
|
| 2013 |
Canal CE, Booth RG, Morgan D. Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model. Neuropharmacology. 70: 112-21. PMID 23353901 DOI: 10.1016/J.Neuropharm.2013.01.007 |
0.355 |
|
| 2012 |
Córdova-Sintjago T, Sakhuja R, Kondabolu K, Canal CE, Booth RG. Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies. International Journal of Quantum Chemistry. 112: 3807-3814. PMID 23913978 DOI: 10.1002/Qua.24237 |
0.336 |
|
| 2012 |
Córdova-Sintjago T, Villa N, Canal C, Booth R. Human serotonin 5-HT2C G protein-coupled receptor homology model from the β2 adrenoceptor structure: Ligand docking and mutagenesis studies International Journal of Quantum Chemistry. 112: 140-149. DOI: 10.1002/Qua.23231 |
0.32 |
|
| 2011 |
Canal CE, Cordova-Sintjago TC, Villa NY, Fang LJ, Booth RG. Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation. European Journal of Pharmacology. 673: 1-12. PMID 22020288 DOI: 10.1016/J.Ejphar.2011.10.006 |
0.341 |
|
| 2011 |
Sadowski RN, Canal CE, Gold PE. Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala. Neurobiology of Learning and Memory. 96: 136-42. PMID 21453778 DOI: 10.1016/J.Nlm.2011.03.007 |
0.573 |
|
| 2010 |
Olaghere da Silva UB, Morabito MV, Canal CE, Airey DC, Emeson RB, Sanders-Bush E. Impact of RNA editing on functions of the serotonin 2C receptor in vivo. Frontiers in Neuroscience. 4: 26. PMID 20582266 DOI: 10.3389/Neuro.23.001.2010 |
0.36 |
|
| 2010 |
Canal CE, Olaghere da Silva UB, Gresch PJ, Watt EE, Sanders-Bush E, Airey DC. The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen. Psychopharmacology. 209: 163-74. PMID 20165943 DOI: 10.1007/s00213-010-1784-0 |
0.364 |
|
| 2009 |
Canal CE, Mahautmr KC, Cao C, Sanders-Bush E, Airey DC. RNA editing of the serotonin 2C receptor and expression of Galpha(q) protein: genetic mouse models do not support a role for regulation or compensation. Journal of Neurochemistry. 108: 1136-42. PMID 19154337 DOI: 10.1111/j.1471-4159.2008.05852.x |
0.328 |
|
| 2008 |
Canal CE, Chang Q, Gold PE. Intra-amygdala injections of CREB antisense impair inhibitory avoidance memory: role of norepinephrine and acetylcholine. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 677-86. PMID 18772255 DOI: 10.1101/lm.904308 |
0.614 |
|
| 2007 |
Canal CE, Gold PE. Different temporal profiles of amnesia after intra-hippocampus and intra-amygdala infusions of anisomycin. Behavioral Neuroscience. 121: 732-41. PMID 17663598 DOI: 10.1037/0735-7044.121.4.732 |
0.593 |
|
| 2007 |
Canal CE, Chang Q, Gold PE. Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 104: 12500-5. PMID 17640910 DOI: 10.1073/pnas.0705195104 |
0.614 |
|
| 2006 |
McNay EC, Canal CE, Sherwin RS, Gold PE. Modulation of memory with septal injections of morphine and glucose: effects on extracellular glucose levels in the hippocampus. Physiology & Behavior. 87: 298-303. PMID 16343563 DOI: 10.1016/J.Physbeh.2005.10.016 |
0.662 |
|
| 2005 |
Canal CE, Stutz SJ, Gold PE. Glucose injections into the dorsal hippocampus or dorsolateral striatum of rats prior to T-maze training: modulation of learning rates and strategy selection. Learning & Memory (Cold Spring Harbor, N.Y.). 12: 367-74. PMID 16027177 DOI: 10.1101/lm.88205 |
0.58 |
|
| 2005 |
Canal CE, McNay EC, Gold PE. Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis study. Physiology & Behavior. 84: 245-50. PMID 15708776 DOI: 10.1016/j.physbeh.2004.11.009 |
0.646 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2014 |
Morgan D, Kondabolu K, Ajufo C, Orza P, Nwokolo J, Sakhuja R, Robertson K, Felsing D, Canal C, Rowland N, Booth R. A novel 5HT2 modulator as a potential antipsychotic medication Drug and Alcohol Dependence. 140: e156. DOI: 10.1016/J.Drugalcdep.2014.02.440 |
0.288 |
|
| 2023 |
Tyagi R, Saraf TS, Canal CE. The Psychedelic ,-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors. Acs Pharmacology & Translational Science. 6: 1480-1491. PMID 37854624 DOI: 10.1021/acsptsci.3c00137 |
0.261 |
|
| 2024 |
Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A. Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT Receptor Agonist. Journal of Medicinal Chemistry. PMID 38593423 DOI: 10.1021/acs.jmedchem.3c01961 |
0.259 |
|
| 2021 |
Rdova-Sintjago TC, Villa N, Canal C, Booth R. Human Serotonin 5-HT G Protein-Coupled Receptor Homology Model from the Adrenoceptor Structure: Ligand Docking and Mutagenesis Studies. International Journal of Quantum Chemistry. 112. PMID 24244046 DOI: 10.1002/qua.23231 |
0.237 |
|
| 2012 |
Canal CE, Morgan D. Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model. Drug Testing and Analysis. 4: 556-76. PMID 22517680 DOI: 10.1002/Dta.1333 |
0.229 |
|
| 2021 |
León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, et al. Activity of ("Kratom") Alkaloids at Serotonin Receptors. Journal of Medicinal Chemistry. PMID 34467758 DOI: 10.1021/acs.jmedchem.1c00726 |
0.227 |
|
| 2022 |
Casey AB, Cui M, Booth RG, Canal CE. "Selective" serotonin 5-HT receptor antagonists. Biochemical Pharmacology. 200: 115028. PMID 35381208 DOI: 10.1016/j.bcp.2022.115028 |
0.225 |
|
| 2019 |
Ray A, Canal CE, Ehlen JC, Rice KC, Murnane KS. M100907 and BD 1047 Attenuate the Acute Toxic Effects of Methamphetamine. Neurotoxicology. PMID 31163210 DOI: 10.1016/J.Neuro.2019.05.011 |
0.215 |
|
| 2015 |
Morgan D, Canal CE, Orza PC, Rose JL, Kim MS, Booth RG. A novel 5HT2C-specific agonist/5HT2A-2B antagonist attenuates psychomotor behaviors induced by methamphetamine, oxycodone, and their combination Drug and Alcohol Dependence. 146: e46. DOI: 10.1016/J.Drugalcdep.2014.09.497 |
0.208 |
|
| 2022 |
Saraf TS, McGlynn RP, Bhatavdekar OM, Booth RG, Canal CE. FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT, 5-HT, and 5-HT Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Knockout Mice. Acs Chemical Neuroscience. 13: 3629-3640. PMID 36473166 DOI: 10.1021/acschemneuro.2c00574 |
0.204 |
|
| 2019 |
Chen Y, Blough BE, Murnane KS, Canal CE. The Synthetic Cathinone Psychostimulant α-PPP Antagonizes Serotonin 5-HT Receptors: In Vitro and In Vivo Evidence. Drug Testing and Analysis. PMID 30845376 DOI: 10.1002/dta.2582 |
0.202 |
|
| 2021 |
Saraf TS, Felsing DE, Armstrong JL, Booth RG, Canal CE. Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice. Epilepsy Research. 175: 106677. PMID 34130255 DOI: 10.1016/j.eplepsyres.2021.106677 |
0.172 |
|
| 2023 |
Saraf TS, Chen Y, Tyagi R, Canal CE. Altered brain serotonin 5-HT receptor expression and function in juvenile Fmr1 knockout mice. Neuropharmacology. 109774. PMID 37923121 DOI: 10.1016/j.neuropharm.2023.109774 |
0.166 |
|
| 2020 |
Armstrong JL, Casey AB, Saraf TS, Mukherjee M, Booth RG, Canal CE. ()-5-(2'-Fluorophenyl)-,-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder. Acs Pharmacology & Translational Science. 3: 509-523. PMID 32566916 DOI: 10.1021/acsptsci.9b00101 |
0.149 |
|
| 2018 |
Canal CE. Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action. Handbook of Experimental Pharmacology. PMID 29532180 DOI: 10.1007/164_2018_107 |
0.13 |
|
| 2019 |
de la Cruz J, Canal C. Can pimavanserin help patients with Parkinson disease psychosis? Jaapa : Official Journal of the American Academy of Physician Assistants. 32: 44-45. PMID 30589736 DOI: 10.1097/01.JAA.0000547757.46299.3d |
0.128 |
|
| 2020 |
Chen Y, Canal CE. Structure-Activity Relationship Study of Psychostimulant Synthetic Cathinones Reveals Nanomolar Antagonist Potency of α-Pyrrolidinohexiophenone (α-PHP) at Human Muscarinic M Receptors. Acs Chemical Neuroscience. PMID 32073252 DOI: 10.1021/acschemneuro.0c00008 |
0.101 |
|
| 2018 |
Ray A, Chitre NM, Daphney CM, Blough BE, Canal CE, Murnane KS. Effects of the second-generation "bath salt" cathinone alpha-pyrrolidinopropiophenone (α-PPP) on behavior and monoamine neurochemistry in male mice. Psychopharmacology. PMID 30276421 DOI: 10.1007/S00213-018-5044-Z |
0.086 |
|
| 2022 |
Armstrong JL, Saraf TS, Bhatavdekar O, Canal CE. Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6bTyrFmr1/J. Epilepsy Research. 182: 106891. PMID 35290907 DOI: 10.1016/j.eplepsyres.2022.106891 |
0.07 |
|
| 2022 |
Canal CE, Leopoldo M. The Need To Improve Reporting of the Pharmacological Action of New Molecules. Acs Chemical Neuroscience. PMID 34989567 DOI: 10.1021/acschemneuro.1c00829 |
0.059 |
|
| 2009 |
Caligaris M, Canal CE, Ahmad CS, Gardner TR, Ateshian GA. Investigation of the frictional response of osteoarthritic human tibiofemoral joints and the potential beneficial tribological effect of healthy synovial fluid. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 17: 1327-32. PMID 19410031 DOI: 10.1016/J.Joca.2009.03.020 |
0.058 |
|
| 2009 |
Ateshian GA, Rajan V, Chahine NO, Canal CE, Hung CT. Modeling the matrix of articular cartilage using a continuous fiber angular distribution predicts many observed phenomena. Journal of Biomechanical Engineering. 131: 061003. PMID 19449957 DOI: 10.1115/1.3118773 |
0.035 |
|
| 2008 |
Canal CE, Hung CT, Ateshian GA. Two-dimensional strain fields on the cross-section of the bovine humeral head under contact loading. Journal of Biomechanics. 41: 3145-51. PMID 18952212 DOI: 10.1016/J.Jbiomech.2008.08.031 |
0.023 |
|
| 2020 |
Lindsley CW, Canal CE. NeuroChat with Professor Clinton E. Canal. Acs Chemical Neuroscience. 11: 3485-3487. PMID 33143427 DOI: 10.1021/acschemneuro.0c00565 |
0.01 |
|
| 2005 |
Canal CE, Chahine NO, Chorney ET, Ateshian GA. Optical measurement of in situ strain fields within bovine humeral head articular layer Proceedings of the 2005 Summer Bioengineering Conference. 2005: 627-628. |
0.01 |
|
| Hide low-probability matches. |