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Brett A. Howell, Ph.D. - Publications

Affiliations: 
2010 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Chemical Engineering, Biomedical Engineering, Pharmacy
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Yang K, Battista C, Woodhead JL, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Systems Pharmacology Modeling of Drug-Induced Hyperbilirubinemia: Differentiating Hepatotoxicity and Inhibition of Enzymes/Transporters. Clinical Pharmacology and Therapeutics. PMID 28074467 DOI: 10.1002/cpt.619  0.389
2016 Yang K, Guo C, Woodhead JL, St Claire RL, Watkins PB, Siler SQ, Howell BA, Brouwer KL. Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury. Journal of Pharmaceutical Sciences. 105: 443-59. PMID 26869411 DOI: 10.1016/J.Xphs.2015.11.008  0.446
2015 Yang Y, Nadanaciva S, Will Y, Woodhead JL, Howell BA, Watkins PB, Siler SQ. MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics. Pharmaceutical Research. 32: 1975-92. PMID 25504454 DOI: 10.1007/s11095-014-1591-0  0.313
2014 Yang K, Woodhead JL, Watkins PB, Howell BA, Brouwer KL. Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity. Clinical Pharmacology and Therapeutics. 96: 589-98. PMID 25068506 DOI: 10.1038/clpt.2014.158  0.304
2014 Howell BA, Siler SQ, Watkins PB. Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice. Toxicology Letters. 226: 163-72. PMID 24560604 DOI: 10.1016/j.toxlet.2014.02.007  0.344
2014 Shoda LK, Woodhead JL, Siler SQ, Watkins PB, Howell BA. Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury. Biopharmaceutics & Drug Disposition. 35: 33-49. PMID 24214486 DOI: 10.1002/bdd.1878  0.436
2012 Bhattacharya S, Shoda LK, Zhang Q, Woods CG, Howell BA, Siler SQ, Woodhead JL, Yang Y, McMullen P, Watkins PB, Andersen ME. Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches. Frontiers in Physiology. 3: 462. PMID 23248599 DOI: 10.3389/Fphys.2012.00462  0.361
2012 Howell BA, Yang Y, Kumar R, Woodhead JL, Harrill AH, Clewell HJ, Andersen ME, Siler SQ, Watkins PB. In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI. Journal of Pharmacokinetics and Pharmacodynamics. 39: 527-41. PMID 22875368 DOI: 10.1007/S10928-012-9266-0  0.357
2010 Howell BA, Chauhan A. A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man. Journal of Pharmaceutical Sciences. 99: 3601-19. PMID 20213834 DOI: 10.1002/Jps.22115  0.609
2010 Howell BA, Chauhan A. Current and Emerging Detoxification Therapies for Critical Care Materials. 3: 2483-2505. DOI: 10.3390/Ma3042483  0.566
2009 Howell BA, Chauhan A. Interaction of cationic drugs with liposomes. Langmuir : the Acs Journal of Surfaces and Colloids. 25: 12056-65. PMID 19821620 DOI: 10.1021/La901644H  0.613
2009 Howell BA, Chauhan A. Bupivacaine binding to pegylated liposomes. Anesthesia and Analgesia. 109: 678-82. PMID 19608847 DOI: 10.1213/Ane.0B013E3181A8Da61  0.614
2009 Fallon MS, Howell BA, Chauhan A. Importance of Taylor dispersion in pharmacokinetic and multiple indicator dilution modelling. Mathematical Medicine and Biology : a Journal of the Ima. 26: 263-96. PMID 19318591 DOI: 10.1093/Imammb/Dqp004  0.467
2009 Kapoor Y, Howell BA, Chauhan A. Liposome assay for evaluating ocular toxicity of surfactants. Investigative Ophthalmology & Visual Science. 50: 2727-35. PMID 19168898 DOI: 10.1167/Iovs.08-2980  0.475
2009 Howell BA, Chauhan A. Binding of imipramine, dosulepin, and opipramol to liposomes for overdose treatment. Journal of Pharmaceutical Sciences. 98: 3718-29. PMID 19156930 DOI: 10.1002/Jps.21683  0.634
2008 Howell B, Chauhan A. Amitriptyline overdose treatment by pegylated anionic liposomes. Journal of Colloid and Interface Science. 324: 61-70. PMID 18502440 DOI: 10.1016/J.Jcis.2008.04.071  0.645
2008 Howell B, Chauhan A. Uptake of amitriptyline and nortriptyline with liposomes, proteins, and serum: implications for drug detoxification. Journal of Colloid and Interface Science. 319: 81-93. PMID 18076894 DOI: 10.1016/J.Jcis.2007.11.018  0.63
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