Year |
Citation |
Score |
2024 |
Lu Y, Yue CX, Zhang L, Yao D, Xia Y, Zhang Q, Zhang X, Li S, Shen Y, Cao M, Guo CR, Qin A, Zhao J, Zhou L, Yu Y, et al. Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1. Science (New York, N.Y.). eadp3252. PMID 39325866 DOI: 10.1126/science.adp3252 |
0.344 |
|
2024 |
Lin YY, Lu Y, Li CY, Ma XF, Shao MQ, Gao YH, Zhang YQ, Jiang HN, Liu Y, Yang Y, Huang LD, Cao P, Wang HS, Wang J, Yu Y. Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors. Nature Communications. 15: 7652. PMID 39227563 DOI: 10.1038/s41467-024-51815-7 |
0.353 |
|
2022 |
Sun MY, Zhang X, Yu PC, Liu D, Yang Y, Cui WW, Yang XN, Lei YT, Li XH, Wang WH, Cao P, Wang HS, Zhu MX, Li CZ, Wang R, ... ... Yu Y, et al. Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1-S4 bundle rather than a quiescent state. Science Bulletin. 67: 1062-1076. PMID 36546250 DOI: 10.1016/j.scib.2022.02.016 |
0.414 |
|
2022 |
Ma XF, Wang TT, Wang WH, Guan L, Guo CR, Li XH, Lei YT, Fan YZ, Yang XN, Hattori M, Nureki O, Zhu MX, Yu Y, Tian Y, Wang J. The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors. The Journal of Biological Chemistry. 102002. PMID 35504351 DOI: 10.1016/j.jbc.2022.102002 |
0.306 |
|
2021 |
Yang PL, Li XH, Wang J, Ma XF, Zhou BY, Jiao YF, Wang WH, Cao P, Zhu MX, Li PW, Xiao ZH, Li CZ, Guo CR, Lei YT, Yu Y. GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6. The Journal of Biological Chemistry. 101125. PMID 34461094 DOI: 10.1016/j.jbc.2021.101125 |
0.323 |
|
2021 |
Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, ... ... Yu Y, et al. The structure of MgtE in the absence of magnesium provides new insights into channel gating. Plos Biology. 19: e3001231. PMID 33905418 DOI: 10.1371/journal.pbio.3001231 |
0.352 |
|
2021 |
Chen PF, Ma XF, Sun LF, Tian Y, Fan YZ, Li P, Xiao Z, Zhu MX, Guo CR, Li C, Yu Y, Wang J. A conserved residue in the P2X4 receptor has a non-conserved function in ATP recognition. The Journal of Biological Chemistry. 100655. PMID 33901491 DOI: 10.1016/j.jbc.2021.100655 |
0.331 |
|
2021 |
Liu Q, Wang J, Wei X, Hu J, Ping C, Gao Y, Xie C, Wang P, Cao P, Cao Z, Yu Y, Li D, Yao J. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine. Elife. 10. PMID 33876725 DOI: 10.7554/eLife.68128 |
0.376 |
|
2021 |
Wang H, Yang P, Lu Y, Wang J, Jeon J, Wang Q, Tian JB, Zang B, Yu Y, Zhu MX. Mechanisms of proton inhibition and sensitization of the cation channel TRPV3. The Journal of General Physiology. 153. PMID 33320167 DOI: 10.1085/jgp.202012663 |
0.453 |
|
2019 |
Sun LF, Liu Y, Wang J, Huang LD, Yang Y, Cheng XY, Fan YZ, Zhu MX, Liang H, Tian Y, Wang HS, Guo CR, Yu Y. Altered allostery of the left flipper domain underlies the weak ATP-response of rat P2X5 receptors. The Journal of Biological Chemistry. PMID 31727741 DOI: 10.1074/Jbc.Ra119.009959 |
0.324 |
|
2018 |
Li B, Wang J, Cheng X, Liu Y, Yang Y, Yang X, Guo C, Niu Y, Cao P, Lu X, Zhu MX, Tian Y, Yu Y. Molecular mechanism underlying the subtype-selectivity of competitive inhibitor NF110 and its distinct potencies in human and rat P2X3 receptors. Science Bulletin. 63: 1616-1625. PMID 36658853 DOI: 10.1016/j.scib.2018.11.016 |
0.303 |
|
2018 |
Li Y, Zhu T, Yang H, Dib-Hajj S, Waxman S, Yu Y, Xu TL, Cheng X. [EXPRESS] Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner. Molecular Pain. 1744806918782229. PMID 29790812 DOI: 10.1177/1744806918782229 |
0.552 |
|
2018 |
Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Göröncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P. The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nature Communications. 9: 1354. PMID 29636447 DOI: 10.1038/S41467-018-03728-5 |
0.443 |
|
2017 |
Yang XN, Niu YY, Liu Y, Yang Y, Jin W, Cheng XY, Liang H, Wang HS, Hu YM, Lu XY, Zhu MX, Xu TL, Tian Y, Yu Y. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of native FMRFamide peptide. The Journal of Biological Chemistry. PMID 29123030 DOI: 10.1074/Jbc.M117.814707 |
0.636 |
|
2017 |
Wang J, Sun LF, Cui WW, Zhao WS, Ma XF, Li B, Liu Y, Yang Y, Hu YM, Huang LD, Cheng XY, Li L, Lu XY, Tian Y, Yu Y. Intersubunit Physical Couplings Fostered By The Left Flipper Domain Facilitate Channel Opening Of P2X4 Receptors. The Journal of Biological Chemistry. PMID 28302727 DOI: 10.1074/jbc.M116.771121 |
0.37 |
|
2016 |
Niu YY, Yang Y, Liu Y, Huang LD, Yang XN, Fan YZ, Cheng XY, Cao P, Hu YM, Li L, Lu XY, Tian Y, Yu Y. Exploration of the Peptide-recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel. The Journal of Biological Chemistry. PMID 26867576 DOI: 10.1074/jbc.M115.710251 |
0.477 |
|
2016 |
Zhao WS, Sun MY, Sun LF, Liu Y, Yang Y, Huang LD, Fan YZ, Cheng XY, Cao P, Hu YM, Li L, Tian Y, Wang R, Yu Y. A Highly Conserved Salt-bridge Stabilizes the Kinked Conformation of β2,3-sheet Essential for Channel Function of P2X4 Receptors. The Journal of Biological Chemistry. PMID 26865631 DOI: 10.1074/jbc.M115.711127 |
0.301 |
|
2016 |
Wang J, Yu Y. Insights into the channel gating of P2X receptors from structures, dynamics and small molecules. Acta Pharmacologica Sinica. 37: 44-55. PMID 26725734 DOI: 10.1038/aps.2015.127 |
0.395 |
|
2014 |
Zhao WS, Wang J, Ma XJ, Yang Y, Liu Y, Huang LD, Fan YZ, Cheng XY, Chen HZ, Wang R, Yu Y. Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation. Nature Communications. 5: 4189. PMID 24943126 DOI: 10.1038/ncomms5189 |
0.405 |
|
2013 |
Wang X, Li WG, Yu Y, Xiao X, Cheng J, Zeng WZ, Peng Z, Xi Zhu M, Xu TL. Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4265-79. PMID 23467344 DOI: 10.1523/Jneurosci.3376-12.2013 |
0.663 |
|
2012 |
Yang H, Gao Z, Li P, Yu K, Yu Y, Xu TL, Li M, Jiang H. A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel. Biophysical Journal. 102: 1815-25. PMID 22768937 DOI: 10.1016/J.Bpj.2012.03.032 |
0.626 |
|
2012 |
Yang Y, Yu Y, Cheng J, Liu Y, Liu DS, Wang J, Zhu MX, Wang R, Xu TL. Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels. The Journal of Biological Chemistry. 287: 14443-55. PMID 22399291 DOI: 10.1074/Jbc.M111.334250 |
0.652 |
|
2011 |
Li WG, Yu Y, Huang C, Cao H, Xu TL. Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride. The Journal of Biological Chemistry. 286: 42635-46. PMID 21998313 DOI: 10.1074/Jbc.M111.289058 |
0.737 |
|
2011 |
Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q, Feng H. Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Annals of Surgery. 254: 353-62. PMID 21725232 DOI: 10.1097/SLA.0b013e31822645b4 |
0.464 |
|
2011 |
Yu Y, Li WG, Chen Z, Cao H, Yang H, Jiang H, Xu TL. Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels. The Journal of Biological Chemistry. 286: 24996-5006. PMID 21586569 DOI: 10.1074/Jbc.M111.239558 |
0.716 |
|
2011 |
Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2101-12. PMID 21307247 DOI: 10.1523/Jneurosci.4351-10.2011 |
0.655 |
|
2010 |
Li WG, Yu Y, Zhang ZD, Cao H, Xu TL. ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Molecular Pain. 6: 88. PMID 21143836 DOI: 10.1186/1744-8069-6-88 |
0.739 |
|
2010 |
Yu Y, Chen Z, Li WG, Cao H, Feng EG, Yu F, Liu H, Jiang H, Xu TL. A nonproton ligand sensor in the acid-sensing ion channel. Neuron. 68: 61-72. PMID 20920791 DOI: 10.1016/J.Neuron.2010.09.001 |
0.719 |
|
2009 |
Yang H, Yu Y, Li WG, Xu TL, Jiang H. Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation. Cell Research. 19: 1035-7. PMID 19636341 DOI: 10.1038/Cr.2009.90 |
0.688 |
|
2009 |
Yang H, Yu Y, Li WG, Yu F, Cao H, Xu TL, Jiang H. Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. Plos Biology. 7: e1000151. PMID 19597538 DOI: 10.1371/Journal.Pbio.1000151 |
0.699 |
|
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