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Karsten Peppel - Publications

Affiliations: 
Duke University, Durham, NC 
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P. S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26005840 DOI: 10.1038/mt.2015.93  0.41
2013 Most P, Lerchenmüller C, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, Goodman C, Busch CJ, Laube F, Heissenberg J, Pleger ST, Weiss N, Katus HA, Koch WJ, Peppel K. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circulation Research. 112: 66-78. PMID 23048072 DOI: 10.1161/CIRCRESAHA.112.275156  0.356
2012 Wu JH, Zhang L, Fanaroff AC, Cai X, Sharma KC, Brian L, Exum ST, Shenoy SK, Peppel K, Freedman NJ. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 308-16. PMID 22095977 DOI: 10.1161/Atvbaha.111.239608  0.805
2011 Li X, Mikhalkova D, Gao E, Zhang J, Myers V, Zincarelli C, Lei Y, Song J, Koch WJ, Peppel K, Cheung JY, Feldman AM, Chan TO. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density American Journal of Physiology - Heart and Circulatory Physiology. 301: H1932-H1940. PMID 21890689 DOI: 10.1152/ajpheart.00755.2010  0.398
2011 Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, von Wegner F, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, et al. The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition. Circulation Research. 108: 27-39. PMID 21106943 DOI: 10.1161/CIRCRESAHA.110.225201  0.502
2011 Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou RH, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G. Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors British Journal of Pharmacology. 162: 712-721. PMID 20958287 DOI: 10.1111/J.1476-5381.2010.01078.X  0.646
2010 Zhu S, Malhotra A, Zhang L, Deng S, Zhang T, Freedman NJ, Storms R, Peppel K, Goldschmidt-Clermont PJ, Dong C. Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice Atherosclerosis. 212: 63-69. PMID 20451204 DOI: 10.1016/J.Atherosclerosis.2010.04.018  0.73
2010 Zhang L, Connelly JJ, Peppel K, Brian L, Shah SH, Nelson S, Crosslin DR, Wang T, Allen A, Kraus WE, Gregory SG, Hauser ER, Freedman NJ. Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. Human Molecular Genetics. 19: 2754-66. PMID 20421368 DOI: 10.1093/Hmg/Ddq172  0.721
2008 Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ. Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circulation Research. 103: 70-9. PMID 18519945 DOI: 10.1161/Circresaha.108.172338  0.778
2008 Zhang L, Sivashanmugam P, Wu JH, Brian L, Exum ST, Freedman NJ, Peppel K. Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 284-9. PMID 18006858 DOI: 10.1161/ATVBAHA.107.151613  0.757
2007 Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H. Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology. 72: 582-91. PMID 17573483 DOI: 10.1124/mol.107.035766  0.802
2007 Zhang L, Peppel K, Sivashanmugam P, Orman ES, Brian L, Exum ST, Freedman NJ. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1087-94. PMID 17442899 DOI: 10.1161/ATVBAHA.0000261548.49790.63  0.742
2006 Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. The Journal of Biological Chemistry. 281: 37758-72. PMID 17018529 DOI: 10.1074/Jbc.M605756200  0.822
2005 Wu JH, Goswami R, Kim LK, Miller WE, Peppel K, Freedman NJ. The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. The Journal of Biological Chemistry. 280: 31027-35. PMID 15994317 DOI: 10.1074/Jbc.M501473200  0.814
2005 Peppel K, Zhang L, Orman ES, Hagen PO, Amalfitano A, Brian L, Freedman NJ. Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. Cardiovascular Research. 65: 674-82. PMID 15664394 DOI: 10.1016/J.Cardiores.2004.10.031  0.729
2004 Zhang L, Peppel K, Brian L, Chien L, Freedman NJ. Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 2277-83. PMID 15486311 DOI: 10.1161/01.ATV.0000147766.68987.0d  0.749
2004 Hildreth KL, Wu JH, Barak LS, Exum ST, Kim LK, Peppel K, Freedman NJ. Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. The Journal of Biological Chemistry. 279: 41775-82. PMID 15271984 DOI: 10.1074/jbc.M403274200  0.796
2004 Zhang L, Freedman NJ, Brian L, Peppel K. Graft-extrinsic cells predominate in vein graft arterialization. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 470-6. PMID 14726410 DOI: 10.1161/01.ATV.0000116865.98067.31  0.719
2003 Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, Exum ST, Freedman NJ. The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. The Journal of Biological Chemistry. 278: 44238-45. PMID 12944399 DOI: 10.1074/Jbc.M309450200  0.753
2003 Bookout AL, Finney AE, Guo R, Peppel K, Koch WJ, Daaka Y. Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. The Journal of Biological Chemistry. 278: 37569-73. PMID 12869546 DOI: 10.1074/jbc.M306276200  0.663
2003 Rau T, Nose M, Remmers U, Weil J, Weissmüller A, Davia K, Harding S, Peppel K, Koch WJ, Eschenhagen T. Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 523-5. PMID 12631586 DOI: 10.1096/Fj.02-0660Fje  0.483
2002 Peppel K, Zhang L, Huynh TT, Huang X, Jacobson A, Brian L, Exum ST, Hagen PO, Freedman NJ. Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia. Journal of Molecular and Cellular Cardiology. 34: 1399-1409. PMID 12393000 DOI: 10.1006/jmcc.2002.2092  0.797
2002 Freedman NJ, Kim LK, Murray JP, Exum ST, Brian L, Wu JH, Peppel K. Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. The Journal of Biological Chemistry. 277: 48261-9. PMID 12381737 DOI: 10.1074/jbc.M204431200  0.792
2002 Zhang L, Hagen PO, Kisslo J, Peppel K, Freedman NJ. Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model. Journal of Vascular Surgery. 36: 824-32. PMID 12368745  0.712
2002 Rau T, Janssen PM, Peppel K, Hasenfuss G, Koch W, Eschenhagen T. Adenoviral gi-protein overexpression: Impact on beta-adrenergic signaling in cardiac myocytes and intact trabeculae Journal of Molecular and Cellular Cardiology. 34: A53. DOI: 10.1016/S0022-2828(02)90935-1  0.483
2000 Peppel K, Jacobson A, Huang X, Murray JP, Oppermann M, Freedman NJ. Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. Circulation. 102: 793-9. PMID 10942749 DOI: 10.1161/01.CIR.102.7.793  0.782
1999 Walker JKL, Peppel K, Lefkowitz RJ, Caron MG, Fisher JT. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 276: R1214-R1221. PMID 29592499 DOI: 10.1152/ajpregu.1999.276.4.R1214  0.606
1999 Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science (New York, N.Y.). 286: 2495-8. PMID 10617462 DOI: 10.1126/Science.286.5449.2495  0.652
1999 Walker JK, Peppel K, Lefkowitz RJ, Caron MG, Fisher JT. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. The American Journal of Physiology. 276: R1214-21. PMID 10198406 DOI: 10.1152/Ajpregu.1999.276.4.R1214  0.496
1998 Gaballa MA, Peppel K, Lefkowitz RJ, Aguirre M, Dolber PC, Pennock GD, Koch WJ, Goldman S. Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. Journal of Molecular and Cellular Cardiology. 30: 1037-45. PMID 9618244 DOI: 10.1006/jmcc.1998.0668  0.614
1998 Kypson AP, Peppel K, Akhter SA, Lilly RE, Glower DD, Lefkowitz RJ, Koch WJ. Ex vivo adenovirus-mediated gene transfer to the adult rat heart. The Journal of Thoracic and Cardiovascular Surgery. 115: 623-30. PMID 9535450 DOI: 10.1016/S0022-5223(98)70327-7  0.719
1997 Peppel K, Koch WJ, Lefkowitz RJ. Gene transfer strategies for augmenting cardiac function. Trends in Cardiovascular Medicine. 7: 145-50. PMID 21235878 DOI: 10.1016/S1050-1738(97)00028-5  0.481
1997 Akhter SA, Skaer CA, Kypson AP, McDonald PH, Peppel KC, Glower DD, Lefkowitz RJ, Koch WJ. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 94: 12100-5. PMID 9342369 DOI: 10.1073/pnas.94.22.12100  0.731
1997 Peppel K, Boekhoff I, McDonald P, Breer H, Caron MG, Lefkowitz RJ. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. The Journal of Biological Chemistry. 272: 25425-8. PMID 9325250 DOI: 10.1074/jbc.272.41.25425  0.629
1997 Drazner MH, Peppel KC, Dyer S, Grant AO, Koch WJ, Lefkowitz RJ. Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. The Journal of Clinical Investigation. 99: 288-96. PMID 9005997 DOI: 10.1172/JCI119157  0.671
1996 Oppermann M, Diversé-Pierluissi M, Drazner MH, Dyer SL, Freedman NJ, Peppel KC, Lefkowitz RJ. Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 93: 7649-54. PMID 8755530 DOI: 10.1073/Pnas.93.15.7649  0.81
1996 Silvestry SC, Peppel K, Lilly R, Heintz G, Koch WJ, Milano C, Glower DD, Lefkowitz RJ. Adenoviral mediated overexpression of human β2 adrenergic receptor after direct delivery into canine myocardium Journal of the American College of Cardiology. 27: 289. DOI: 10.1016/S0735-1097(96)82047-X  0.574
1995 Kingsmore SF, Peppel K, Suh D, Caron MG, Lefkowitz RJ, Seldin MF. Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 306-7. PMID 7613043 DOI: 10.1007/BF00352426  0.525
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