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Aaron Janowsky, Ph.D. - Publications

Affiliations: 
Psychiatry Oregon Health and Science University, Portland, OR 
Area:
neurotransmitter transporter function and regulation, G-protein coupled receptors, receptor regulation, signal transduction systems, neuropsychiatric disorders, schizophrenia, addiction, methamphetamine, cocaine, pharmacotherapy development
Website:
http://www.ohsu.edu/xd/education/schools/school-of-medicine/academic-programs/graduate-studies/faculty/grad-studies-faculty.cfm?facultyid=169
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Torralva R, Eshleman AJ, Swanson TL, Schmachtenberg JL, Schutzer WE, Bloom SH, Wolfrum KM, Reed JF, Janowsky A. Fentanyl but not Morphine Interacts with Non-Opioid Recombinant Human Neurotransmitter Receptors and Transporters. The Journal of Pharmacology and Experimental Therapeutics. PMID 32513839 DOI: 10.1124/Jpet.120.265561  0.386
2019 Loftis JM, Lasarev M, Shi X, Lapidus J, Janowsky A, Hoffman WF, Huckans M. Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence. Plos One. 14: e0220270. PMID 31600226 DOI: 10.1371/Journal.Pone.0220270  0.313
2019 Shi X, Swanson TL, Miner NB, Eshleman AJ, Janowsky A. Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2. Molecular Pharmacology. 96: 493-504. PMID 31409621 DOI: 10.1124/Mol.119.116798  0.337
2019 Miner NB, Phillips TJ, Janowsky A. The role of biogenic amine transporters in trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity. The Journal of Pharmacology and Experimental Therapeutics. PMID 31320495 DOI: 10.1124/Jpet.119.258970  0.436
2018 Eshleman AJ, Wolfrum KM, Reed JF, Kim SO, Johnson RA, Janowsky A. Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: high potency agonists at 5-HT receptors. Biochemical Pharmacology. PMID 30261175 DOI: 10.1016/J.Bcp.2018.09.024  0.343
2018 Provencher B, Eshleman AJ, Johnson RA, Shi X, Kryatova O, Nelson J, Tian J, Gonzalez M, Meltzer PC, Janowsky A. Synthesis and Discovery of Arylpiperidinylquinazolines: new inhibitors of the vesicular monoamine transporter. Journal of Medicinal Chemistry. PMID 30240563 DOI: 10.1021/Acs.Jmedchem.8B00542  0.422
2017 Eastwood EC, Eshleman AJ, Janowsky A, Phillips TJ. Verification of a genetic locus for methamphetamine intake and the impact of morphine. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29127441 DOI: 10.1007/S00335-017-9724-5  0.301
2017 Miner NB, Elmore JS, Baumann MH, Phillips TJ, Janowsky A. Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity. Neurotoxicology. PMID 28919515 DOI: 10.1016/J.Neuro.2017.09.006  0.334
2017 Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA. Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. Journal of Medicinal Chemistry. PMID 28319392 DOI: 10.1021/Acs.Jmedchem.7B00141  0.444
2017 Miner NB, O'Callaghan JP, Phillips TJ, Janowsky A. The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity. Neurotoxicology and Teratology. PMID 28212938 DOI: 10.1016/J.Ntt.2017.02.003  0.351
2016 Zou MF, Keck TM, Kumar V, Donthamsetti P, Michino M, Burzynski C, Schweppe C, Bonifazi A, Free RB, Sibley DR, Janowsky A, Shi L, Javitch JA, Newman AH. Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. Journal of Medicinal Chemistry. PMID 27035329 DOI: 10.1021/Acs.Jmedchem.5B01612  0.405
2016 Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A. Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function. Plos One. 11: e0152581. PMID 27031617 DOI: 10.1371/Journal.Pone.0152581  0.354
2016 Janowsky A, Tosh DK, Eshleman AJ, Jacobson KA. Rigid adenine nucleoside derivatives as novel modulators of the human sodium symporters for dopamine and other neurotransmitters. The Journal of Pharmacology and Experimental Therapeutics. PMID 26813929 DOI: 10.1124/Jpet.115.229666  0.443
2015 Harkness JH, Shi X, Janowsky A, Phillips TJ. Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2175-84. PMID 25740289 DOI: 10.1038/Npp.2015.61  0.314
2014 Janowsky A, Eshleman AJ, Johnson RA, Wolfrum KM, Hinrichs DJ, Yang J, Zabriskie TM, Smilkstein MJ, Riscoe MK. Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro. Psychopharmacology. 231: 2771-83. PMID 24488404 DOI: 10.1007/S00213-014-3446-0  0.305
2013 Antonio T, Childers SR, Rothman RB, Dersch CM, King C, Kuehne M, Bornmann WG, Eshleman AJ, Janowsky A, Simon ER, Reith ME, Alper K. Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation. Plos One. 8: e77262. PMID 24204784 DOI: 10.1371/Journal.Pone.0077262  0.301
2013 Eshleman AJ, Wolfrum KM, Hatfield MG, Johnson RA, Murphy KV, Janowsky A. Substituted methcathinones differ in transporter and receptor interactions. Biochemical Pharmacology. 85: 1803-15. PMID 23583454 DOI: 10.1016/J.Bcp.2013.04.004  0.474
2012 Keith DJ, Wolfrum K, Eshleman AJ, Janowsky A. Melittin initiates dopamine transporter internalization and recycling in transfected HEK-293 cells. European Journal of Pharmacology. 690: 13-21. PMID 22683840 DOI: 10.1016/J.Ejphar.2012.05.020  0.372
2011 Gatch MB, Forster MJ, Janowsky A, Eshleman AJ. Abuse liability profile of three substituted tryptamines. The Journal of Pharmacology and Experimental Therapeutics. 338: 280-9. PMID 21474568 DOI: 10.1124/Jpet.111.179705  0.369
2011 Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC. The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. Bioorganic & Medicinal Chemistry Letters. 21: 48-51. PMID 21146984 DOI: 10.1016/J.Bmcl.2010.11.076  0.388
2011 Keith DJ, Eshleman AJ, Janowsky A. Melittin stimulates fatty acid release through non-phospholipase-mediated mechanisms and interacts with the dopamine transporter and other membrane-spanning proteins. European Journal of Pharmacology. 650: 501-10. PMID 20969853 DOI: 10.1016/J.Ejphar.2010.10.023  0.413
2009 Wheeler JM, Reed C, Burkhart-Kasch S, Li N, Cunningham CL, Janowsky A, Franken FH, Wiren KM, Hashimoto JG, Scibelli AC, Phillips TJ. Genetically correlated effects of selective breeding for high and low methamphetamine consumption. Genes, Brain, and Behavior. 8: 758-71. PMID 19689456 DOI: 10.1111/J.1601-183X.2009.00522.X  0.328
2009 Voelker T, Xia H, Fandrick K, Johnson R, Janowsky A, Cashman JR. 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorganic & Medicinal Chemistry. 17: 2047-68. PMID 19201198 DOI: 10.1016/J.Bmc.2009.01.023  0.386
2009 Cashman JR, Voelker T, Johnson R, Janowsky A. Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorganic & Medicinal Chemistry. 17: 337-43. PMID 19014888 DOI: 10.1016/J.Bmc.2008.10.065  0.3
2008 Wilhelm CJ, Johnson RA, Eshleman AJ, Janowsky A. Lobeline effects on tonic and methamphetamine-induced dopamine release. Biochemical Pharmacology. 75: 1411-5. PMID 18191815 DOI: 10.1016/J.Bcp.2007.11.019  0.405
2008 Meltzer PC, Kryatova O, Pham-Huu DP, Donovan P, Janowsky A. The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters. Bioorganic & Medicinal Chemistry. 16: 1832-41. PMID 18053732 DOI: 10.1016/J.Bmc.2007.11.009  0.365
2007 Kelly JX, Smilkstein MJ, Cooper RA, Lane KD, Johnson RA, Janowsky A, Dodean RA, Hinrichs DJ, Winter R, Riscoe M. Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 51: 4133-40. PMID 17846138 DOI: 10.1128/Aac.00669-07  0.308
2007 Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E. Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. The Journal of Pharmacology and Experimental Therapeutics. 321: 1208-25. PMID 17325229 DOI: 10.1124/Jpet.106.116483  0.302
2007 Froimowitz M, Gu Y, Dakin LA, Nagafuji PM, Kelley CJ, Parrish D, Deschamps JR, Janowsky A. Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. Journal of Medicinal Chemistry. 50: 219-32. PMID 17228864 DOI: 10.1021/Jm0608614  0.378
2006 Popik P, Krawczyk M, Golembiowska K, Nowak G, Janowsky A, Skolnick P, Lippa A, Basile AS. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and Molecular Neurobiology. 26: 857-73. PMID 16636898 DOI: 10.1007/S10571-006-9012-5  0.436
2006 Wilhelm CJ, Johnson RA, Eshleman AJ, Janowsky A. Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux. Journal of Neurochemistry. 96: 1149-59. PMID 16417578 DOI: 10.1111/J.1471-4159.2005.03611.X  0.348
2004 Wilhelm CJ, Johnson RA, Lysko PG, Eshleman AJ, Janowsky A. Effects of methamphetamine and lobeline on vesicular monoamine and dopamine transporter-mediated dopamine release in a cotransfected model system. The Journal of Pharmacology and Experimental Therapeutics. 310: 1142-51. PMID 15102929 DOI: 10.1124/Jpet.104.067314  0.387
2003 Shimazu S, Tsunekawa H, Yoneda F, Katsuki H, Akaike A, Janowsky A. Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane. European Journal of Pharmacology. 482: 9-16. PMID 14659999 DOI: 10.1016/J.Ejphar.2003.09.044  0.427
2003 Skolnick P, Popik P, Janowsky A, Beer B, Lippa AS. "Broad spectrum" antidepressants: is more better for the treatment of depression? Life Sciences. 73: 3175-9. PMID 14561522 DOI: 10.1016/J.Lfs.2003.06.007  0.375
2003 Skolnick P, Popik P, Janowsky A, Beer B, Lippa AS. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. European Journal of Pharmacology. 461: 99-104. PMID 12586204 DOI: 10.1016/S0014-2999(03)01310-4  0.381
2002 Loftis JM, Janowsky A. Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit. Psychopharmacology. 164: 349-59. PMID 12457264 DOI: 10.1007/S00213-002-1209-9  0.325
2002 Houlihan WJ, Kelly L, Pankuch J, Koletar J, Brand L, Janowsky A, Kopajtic TA. Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of Medicinal Chemistry. 45: 4097-109. PMID 12213053 DOI: 10.1021/jm010302r  0.322
2001 Janowsky A, Neve K, Eshleman AJ. Uptake and release of neurotransmitters. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit7.9. PMID 18428535 DOI: 10.1002/0471142301.Ns0709S02  0.367
2001 Mason JN, Eshleman AJ, Belknap JK, Crabbe JC, Loftis JM, Macey TA, Janowsky A. NMDA Receptor Subunit mRNA and Protein Expression in Ethanol‐Withdrawal Seizure‐Prone and ‐Resistant Mice Alcoholism: Clinical and Experimental Research. 25: 651-660. DOI: 10.1111/J.1530-0277.2001.Tb02263.X  0.31
2000 Loftis JM, Janowsky A. Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal. Journal of Neurochemistry. 75: 2040-50. PMID 11032893 DOI: 10.1046/J.1471-4159.2000.0752040.X  0.332
1999 Eshleman AJ, Carmolli M, Cumbay M, Martens CR, Neve KA, Janowsky A. Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type. The Journal of Pharmacology and Experimental Therapeutics. 289: 877-85. PMID 10215666  0.312
1998 Johnson RA, Eshleman AJ, Meyers T, Neve KA, Janowsky A. [3H]substrate- and cell-specific effects of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux. Synapse (New York, N.Y.). 30: 97-106. PMID 9704886 DOI: 10.1002/(Sici)1098-2396(199809)30:1<97::Aid-Syn12>3.0.Co;2-M  0.411
1997 Eshleman AJ, Stewart E, Evenson AK, Mason JN, Blakely RD, Janowsky A, Neve KA. Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. Journal of Neurochemistry. 69: 1459-66. PMID 9326274 DOI: 10.1046/J.1471-4159.1997.69041459.X  0.374
1996 Meshul CK, Bunker GL, Mason JN, Allen C, Janowsky A. Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses. Journal of Neurochemistry. 67: 1965-73. PMID 8863502 DOI: 10.1046/J.1471-4159.1996.67051965.X  0.336
1995 Eshleman AJ, Neve RL, Janowsky A, Neve KA. Characterization of a recombinant human dopamine transporter in multiple cell lines. The Journal of Pharmacology and Experimental Therapeutics. 274: 276-83. PMID 7616409  0.302
1995 Carter LA, Belknap JK, Crabbe JC, Janowsky A. Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice. Journal of Neurochemistry. 64: 213-9. PMID 7528263 DOI: 10.1046/J.1471-4159.1995.64010213.X  0.366
1994 Meshul CK, Stallbaumer RK, Taylor B, Janowsky A. Haloperidol-induced morphological changes in striatum are associated with glutamate synapses. Brain Research. 648: 181-95. PMID 7922533 DOI: 10.1016/0006-8993(94)91117-7  0.355
1992 Janowsky A, Neve KA, Kinzie JM, Taylor B, de Paulis T, Belknap JK. Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine. The Journal of Pharmacology and Experimental Therapeutics. 261: 1282-90. PMID 1534844  0.33
1992 Meshul CK, Janowsky A, Casey DE, Stallbaumer RK, Taylor B. Effect of haloperidol and clozapine on the density of "perforated" synapses in caudate, nucleus accumbens, and medial prefrontal cortex. Psychopharmacology. 106: 45-52. PMID 1531388 DOI: 10.1007/Bf02253587  0.405
1991 Neve KA, Neve RL, Fidel S, Janowsky A, Higgins GA. Increased abundance of alternatively spliced forms of D2 dopamine receptor mRNA after denervation. Proceedings of the National Academy of Sciences of the United States of America. 88: 2802-6. PMID 1826366 DOI: 10.1073/Pnas.88.7.2802  0.348
1990 Neve KA, Henningsen RA, Kinzie JM, De Paulis T, Schmidt DE, Kessler RM, Janowsky A. Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand. The Journal of Pharmacology and Experimental Therapeutics. 252: 1108-16. PMID 2138666  0.308
1990 Davis DA, de Paulis T, Janowsky A, Smith HE. Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. Journal of Medicinal Chemistry. 33: 809-14. PMID 1967652 DOI: 10.1021/Jm00164A053  0.386
1989 Rupard JH, de Paulis T, Janowsky A, Smith HE. Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. Journal of Medicinal Chemistry. 32: 2261-8. PMID 2571728 DOI: 10.1021/Jm00130A006  0.311
1989 Janowsky A, Berger SP. Clozapine inhibits [3H]MK-801 binding to the glutamate receptor — ion channel complex Schizophrenia Research. 2: 189. DOI: 10.1016/0920-9964(89)90225-9  0.335
1988 Janowsky A, De Paulis T, Clanton JA, Smith HE, Ebert MH, Kessler RM. [125I]iodopride: a specific high affinity radioligand for labelling striatal dopamine D-2 receptors. European Journal of Pharmacology. 150: 203-5. PMID 3402540 DOI: 10.1016/0014-2999(88)90772-8  0.396
1988 de Paulis T, Janowsky A, Kessler RM, Clanton JA, Smith HE. (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors. Journal of Medicinal Chemistry. 31: 2027-33. PMID 3172140 DOI: 10.1021/Jm00118A031  0.38
1987 Janowsky A, Vocci F, Berger P, Angel I, Zelnik N, Kleinman JE, Skolnick P, Paul SM. [3H]GBR-12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease. Journal of Neurochemistry. 49: 617-21. PMID 3598589 DOI: 10.1111/J.1471-4159.1987.Tb02908.X  0.389
1987 Labarca R, Janowsky A, Paul SM. Neurotransmitter-stimulated inositol phosphate accumulation in hippocampal slices. Methods in Enzymology. 141: 192-201. PMID 2885715 DOI: 10.1016/0076-6879(87)41067-7  0.361
1986 Janowsky A, Berger P, Vocci F, Labarca R, Skolnick P, Paul SM. Characterization of sodium-dependent [3H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex. Journal of Neurochemistry. 46: 1272-6. PMID 3081686 DOI: 10.1111/J.1471-4159.1986.Tb00649.X  0.406
1983 Sulser F, Manier DH, Janowsky AJ, Okada F. Regulation of noradrenergic receptor systems in brain that are coupled to adenylate cyclase. Journal of Neural Transmission. Supplementum. 18: 121-30. PMID 6308146 DOI: 10.1007/978-3-7091-4408-4_11  0.341
1983 Sulser F, Janowsky AJ, Okada F, Manier DH, Mobley PL. Regulation of recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: implications for the therapy of depression. Neuropharmacology. 22: 425-31. PMID 6304560 DOI: 10.1016/0028-3908(83)90192-2  0.325
1982 Janowsky A, Okada F, Manier DH, Applegate CD, Sulser F, Steranka LR. Role of serotonergic input in the regulation of the beta-adrenergic receptor-coupled adenylate cyclase system. Science (New York, N.Y.). 218: 900-1. PMID 6291152 DOI: 10.1126/Science.6291152  0.309
1982 Janowsky A, Steranka LR, Gillespie DD, Sulser F. Role of neuronal signal input in the down-regulation of central noradrenergic receptor function by antidepressant drugs. Journal of Neurochemistry. 39: 290-2. PMID 6283020 DOI: 10.1111/J.1471-4159.1982.Tb04739.X  0.335
1980 Mishra R, Janowsky A, Sulser F. Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding. Neuropharmacology. 19: 983-7. PMID 6252500 DOI: 10.1016/0028-3908(80)90009-X  0.407
1979 Mishra R, Janowsky A, Sulser F. Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: effects of nisoxetine versus fluoxetine. European Journal of Pharmacology. 60: 379-82. PMID 316774 DOI: 10.1016/0014-2999(79)90246-2  0.413
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