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Amy H. Newman - Publications

Affiliations: 
Medicinal Chemistry National Institutes of Health, Bethesda, MD 
Area:
G-protein coupled receptors
Website:
http://irp.drugabuse.gov/Newman.php

235 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Battiti FO, Zaidi SA, Katritch V, Newman AH, Bonifazi A. Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D or D Receptor Agonists. Journal of Medicinal Chemistry. 64: 16088-16105. PMID 34699207 DOI: 10.1021/acs.jmedchem.1c01433  0.463
2021 Shaik AB, Boateng CA, Battiti FO, Bonifazi A, Cao J, Chen L, Chitsazi R, Ravi S, Lee KH, Shi L, Newman AH. Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D/D Receptor Bitopic Ligands. Journal of Medicinal Chemistry. PMID 34636551 DOI: 10.1021/acs.jmedchem.1c01353  0.427
2021 Bonifazi A, Newman AH, Keck TM, Gervasoni S, Vistoli G, Del Bello F, Giorgioni G, Pavletić P, Quaglia W, Piergentili A. Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders. Acs Chemical Neuroscience. PMID 34529404 DOI: 10.1021/acschemneuro.1c00368  0.474
2021 Lee KH, Fant AD, Guo J, Guan A, Jung J, Kudaibergenova M, Miranda WE, Ku T, Cao J, Wacker S, Duff HJ, Newman AH, Noskov SY, Shi L. Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach. Journal of Chemical Information and Modeling. PMID 34420294 DOI: 10.1021/acs.jcim.1c00856  0.362
2021 Bonifazi A, Battiti FO, Sanchez J, Zaidi SA, Bow E, Makarova M, Cao J, Shaik AB, Sulima A, Rice KC, Katritch V, Canals M, Lane JR, Newman AH. Novel Dual-Target μ-Opioid Receptor and Dopamine D Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management. Journal of Medicinal Chemistry. PMID 34011153 DOI: 10.1021/acs.jmedchem.1c00611  0.421
2021 Adhikari P, Xie B, Semeano A, Bonifazi A, Battiti FO, Newman AH, Yano H, Shi L. Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor. Biomolecules. 11. PMID 33924613 DOI: 10.3390/biom11040570  0.461
2021 Witkin JM, Cerne R, Newman AH, Izenwasser S, Smith JL, Tortella FC. N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo:Evidence from an NMDA-induced seizure model in rats. Pharmacology, Biochemistry, and Behavior. 173154. PMID 33609599 DOI: 10.1016/j.pbb.2021.173154  0.326
2021 Newman AH, Ku T, Jordan CJ, Bonifazi A, Xi ZX. New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders. Annual Review of Pharmacology and Toxicology. 61: 609-628. PMID 33411583 DOI: 10.1146/annurev-pharmtox-030220-124205  0.393
2020 Moritz AE, Bonifazi A, Guerrero AM, Kumar V, Free RB, Lane JR, Verma RK, Shi L, Newman AH, Sibley DR. Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor. Acs Chemical Neuroscience. PMID 32969645 DOI: 10.1021/acschemneuro.0c00425  0.463
2020 Giancola JB, Bonifazi A, Cao J, Ku T, Haraczy AJ, Lam J, Rais R, Coggiano MA, Tanda G, Newman AH. Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability. European Journal of Medicinal Chemistry. 208: 112674. PMID 32947229 DOI: 10.1016/J.Ejmech.2020.112674  0.459
2020 Tanda G, Hersey M, Hempel B, Xi ZX, Newman AH. Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder. Current Opinion in Pharmacology. 56: 13-21. PMID 32927246 DOI: 10.1016/J.Coph.2020.07.007  0.395
2020 Guthrie D, Klein Herenbrink C, Lycas M, Ku T, Bonifazi A, DeVree B, Mathiasen S, Javitch J, Grimm JB, Lavis LD, Gether U, Newman AH. Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. Acs Chemical Neuroscience. PMID 32926777 DOI: 10.1021/Acschemneuro.0C00397  0.466
2020 Jordan CJ, He Y, Bi GH, You ZB, Cao J, Xi ZX, Newman AH. (±)VK4-40, a Novel D R Partial Agonist, Attenuates Cocaine Reward and Relapse in Rodents. British Journal of Pharmacology. PMID 32851643 DOI: 10.1111/Bph.15244  0.465
2020 Zhu R, Sandtner W, Ahiable JEA, Newman AH, Freissmuth M, Sitte HH, Hinterdorfer P. Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy. Frontiers in Molecular Biosciences. 7: 99. PMID 32656227 DOI: 10.3389/Fmolb.2020.00099  0.308
2020 Schweppe CA, Burzynski C, Jayanthi S, Ladenheim B, Cadet JL, Gardner EL, Xi ZX, van Praag H, Newman AH, Keck TM. Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms. Psychopharmacology. PMID 32388619 DOI: 10.1007/S00213-020-05513-Z  0.711
2020 Galaj E, Newman AH, Xi ZX. Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges. Neuroscience and Biobehavioral Reviews. PMID 32376243 DOI: 10.1016/J.Neubiorev.2020.04.024  0.43
2020 Mereu M, Hiranita T, Jordan CJ, Chun LE, Lopez JP, Coggiano MA, Quarterman JC, Bi GH, Keighron JD, Xi ZX, Newman AH, Katz JL, Tanda G. Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32340023 DOI: 10.1038/S41386-020-0680-5  0.429
2020 Tanda G, Mereu M, Hiranita T, Jordan CJ, Chun LE, Lopez JP, Coggiano MA, Quarterman JC, Bi G, Keighron JD, Xi Z, Katz JL, Newman AH. Gap Junctions Modulate The Effects Of Modafinil On Cocaine Self‐Administration Behavior In A Dopamine‐Independent Fashion In Rats The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04150  0.352
2019 de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. Dopamine D Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. Frontiers in Behavioral Neuroscience. 13: 292. PMID 31992976 DOI: 10.3389/Fnbeh.2019.00292  0.461
2019 Slack RD, Ku T, Cao J, Giancola J, Bonifazi A, Loland CJ, Gadiano A, Lam J, Rais R, Slusher BS, Coggiano M, Tanda G, Newman AH. Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability. Journal of Medicinal Chemistry. PMID 31661268 DOI: 10.1021/Acs.Jmedchem.9B01188  0.5
2019 Shaik AB, Kumar V, Bonifazi A, Guerrero A, Cemaj S, Gadiano A, Lam J, Xi ZX, Rais R, Slusher BS, Newman AH. Investigation of novel primary and secondary pharmacophores, and 3-substitution in the linking chain of a series of highly selective and bitopic dopamine D3 receptor antagonists and partial agonists. Journal of Medicinal Chemistry. PMID 31526003 DOI: 10.1021/Acs.Jmedchem.9B00607  0.562
2019 Slack RD, Abramyan AM, Tang H, Meena S, Davis BA, Bonifazi A, Giancola JB, Deschamps JR, Naing S, Yano H, Singh SKK, Newman AH, Shi L. A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter. Acs Chemical Neuroscience. PMID 31424193 DOI: 10.1021/Acschemneuro.9B00375  0.385
2019 Battiti FO, Cemaj SL, Guerrero AM, Shaik AB, Lam J, Rais R, Slusher BS, Deschamps JR, Imler GH, Newman AH, Bonifazi A. The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D Receptor (DR) Selective Agonists. Journal of Medicinal Chemistry. PMID 31257877 DOI: 10.1021/Acs.Jmedchem.9B00702  0.577
2019 Bhat S, Newman AH, Freissmuth M. How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers. Biochemical Society Transactions. PMID 31064865 DOI: 10.1042/Bst20180512  0.39
2019 Jordan CJ, Humburg B, Rice M, Bi GH, You ZB, Shaik AB, Cao J, Bonifazi A, Gadiano A, Rais R, Slusher B, Newman AH, Xi ZX. The highly selective dopamine DR antagonist, RVK4-40, attenuates oxycodone reward and augments analgesia in rodents. Neuropharmacology. PMID 30974107 DOI: 10.1016/J.Neuropharm.2019.04.003  0.429
2019 Guitart X, Moreno E, Rea W, Sánchez-Soto M, Cai NS, Quiroz C, Kumar V, Bourque L, Cortés A, Canela EI, Bishop C, Newman AH, Casadó V, Ferré S. Biased G Protein-Independent Signaling of Dopamine D-D Receptor Heteromers in the Nucleus Accumbens. Molecular Neurobiology. PMID 30919214 DOI: 10.1007/S12035-019-1564-8  0.461
2019 Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, ... ... Newman AH, et al. Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids. The Journal of Clinical Investigation. 130. PMID 30913037 DOI: 10.1172/Jci126912  0.513
2019 Keck TM, Free RB, Day MM, Brown SL, Maddaluna MS, Fountain G, Cooper C, Fallon B, Holmes M, Stang C, Burkhardt R, Bonifazi A, Ellenberger MP, Newman AH, Sibley DR, et al. Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy. Journal of Medicinal Chemistry. PMID 30883109 DOI: 10.1021/Acs.Jmedchem.9B00231  0.821
2019 Manvich DF, Petko AK, Branco RC, Foster SL, Porter-Stransky KA, Stout KA, Newman AH, Miller GW, Paladini CA, Weinshenker D. Selective D and D receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30879021 DOI: 10.1038/S41386-019-0371-2  0.5
2019 Newman AH, Cao J, Keighron JD, Jordan CJ, Bi GH, Liang Y, Abramyan AM, Avelar AJ, Tschumi CW, Beckstead MJ, Shi L, Tanda G, Xi ZX. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30858517 DOI: 10.1038/S41386-019-0366-Z  0.474
2019 Bonifazi A, Yano H, Guerrero AM, Kumar V, Hoffman AF, Lupica CR, Shi L, Newman AH. Novel and Potent Dopamine D Receptor Go-Protein Biased Agonists. Acs Pharmacology & Translational Science. 2: 52-65. PMID 30775693 DOI: 10.1021/acsptsci.8b00060  0.467
2019 Keighron JD, Quarterman JC, Cao J, DeMarco E, Coggiano MA, Gleaves A, Slack RD, Zanettini C, Newman AH, Tanda G. Effects of R-Modafinil and Modafinil Analogs on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell. Acs Chemical Neuroscience. PMID 30645944 DOI: 10.1021/Acschemneuro.8B00340  0.478
2019 Del Bello F, Ambrosini D, Bonifazi A, Newman AH, Keck TM, Giannella M, Giorgioni G, Piergentili A, Cappellacci L, Cilia A, Franchini S, Quaglia W. Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia. Acs Chemical Neuroscience. PMID 30609891 DOI: 10.1021/Acschemneuro.8B00677  0.79
2018 You ZB, Bi GH, Galaj E, Kumar V, Cao J, Gadiano A, Rais R, Slusher BS, Gardner EL, Xi ZX, Newman AH. Dopamine DR antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30555159 DOI: 10.1038/S41386-018-0284-5  0.42
2018 Zanettini C, Scaglione A, Keighron JD, Giancola JB, Lin SC, Newman AH, Tanda G. Pharmacological classification of centrally acting drugs using EEG in freely moving rats: An old tool to identify new atypical dopamine uptake inhibitors. Neuropharmacology. PMID 30481526 DOI: 10.1016/J.Neuropharm.2018.11.034  0.349
2018 Keighron JD, Giancola JB, Shaffer RJ, DeMarco EM, Coggiano MA, Slack RD, Newman AH, Tanda G. Distinct Effects of (R)-Modafinil and its (R)- and (S)-Fluoro-Analogs on Mesolimbic Extracellular Dopamine Assessed by Voltammetry and Microdialysis in Rats. The European Journal of Neuroscience. PMID 30402972 DOI: 10.1111/Ejn.14256  0.463
2018 Abramyan AM, Slack RD, Meena S, Davis BA, Newman AH, Singh SK, Shi L. Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics. Neuropharmacology. PMID 30391505 DOI: 10.1016/J.Neuropharm.2018.10.040  0.365
2018 Liow JS, Morse CL, Lu S, Frankland M, Tye GL, Zoghbi SS, Gladding RL, Shaik AB, Innis RB, Newman AH, Pike VW. [--C]-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1-indole-2-carboxamide ([C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey. Molecules (Basel, Switzerland). 23. PMID 30360553 DOI: 10.3390/Molecules23112737  0.419
2018 Tomlinson MJ, Krout D, Pramod AB, Lever JR, Newman AH, Henry LK, Vaughan RA. Identification of the benztropine analog [I]GA II 34 binding site on the human dopamine transporter. Neurochemistry International. PMID 30125594 DOI: 10.1016/J.Neuint.2018.08.008  0.473
2018 Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP. Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. Neuron. PMID 29656874 DOI: 10.1016/J.Neuron.2018.03.038  0.509
2018 Yano H, Bonifazi A, Xu M, Guthrie DA, Schneck SN, Abramyan AM, Fant AD, Hong WC, Newman AH, Shi L. Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays. Neuropharmacology. PMID 29407216 DOI: 10.1016/J.Neuropharm.2018.01.042  0.412
2017 Czoty PW, John WS, Newman AH, Nader MA. Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine Dreceptors. Alcohol (Fayetteville, N.Y.). 69: 1-5. PMID 29550583 DOI: 10.1016/J.Alcohol.2017.10.003  0.31
2017 Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH. Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. Journal of Medicinal Chemistry. PMID 29227643 DOI: 10.1021/Acs.Jmedchem.7B01454  0.461
2017 Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 131: 96-103. PMID 29217282 DOI: 10.1016/J.Neuropharm.2017.12.006  0.406
2017 Yepes G, Guitart X, Rea W, Newman AH, Allen RP, Earley CJ, Quiroz C, Ferré S. Targeting Hypersensitive Corticostriatal Terminals in Restless Legs Syndrome. Annals of Neurology. PMID 29171915 DOI: 10.1002/Ana.25104  0.357
2017 You ZB, Gao JT, Bi GH, He Y, Boateng C, Cao J, Gardner EL, Newman AH, Xi ZX. The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats. Neuropharmacology. PMID 28888944 DOI: 10.1016/J.Neuropharm.2017.09.007  0.46
2017 Krout D, Pramod AB, Dahal RA, Tomlinson MJ, Sharma B, Foster JD, Zou MF, Boatang C, Newman AH, Lever JR, Vaughan RA, Henry LK. Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochemical Pharmacology. PMID 28734777 DOI: 10.1016/J.Bcp.2017.07.015  0.388
2017 Ma S, Cheng MH, Guthrie DA, Newman AH, Bahar I, Sorkin A. Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter. Scientific Reports. 7: 5399. PMID 28710426 DOI: 10.1038/S41598-017-05637-X  0.371
2017 Avelar AJ, Cao J, Newman AH, Beckstead MJ. Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons. Neuropharmacology. PMID 28625719 DOI: 10.1016/j.neuropharm.2017.06.016  0.472
2017 Bonifazi A, Yano H, Ellenberger MP, Muller L, Kumar V, Zou MF, Cai NS, Guerrero AM, Woods AS, Shi L, Newman AH. Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism. Journal of Medicinal Chemistry. PMID 28300398 DOI: 10.1021/Acs.Jmedchem.6B01875  0.814
2017 Zhang HY, Bi GH, Yang HJ, He Y, Xue G, Cao JJ, Tanda G, Gardner EL, Newman AH, Xi ZX. The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28266501 DOI: 10.1038/Npp.2017.41  0.477
2017 Kumar V, Moritz AE, Keck TM, Bonifazi A, Ellenberger MP, Sibley CD, Free RB, Shi L, Lane JR, Sibley DR, Newman AH. Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R). Journal of Medicinal Chemistry. PMID 28186762 DOI: 10.1021/Acs.Jmedchem.6B01688  0.817
2016 Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L. Towards understanding the structural basis of partial agonism at the dopamine D3 receptor. Journal of Medicinal Chemistry. PMID 27983845 DOI: 10.1021/Acs.Jmedchem.6B01148  0.812
2016 Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH. Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. Journal of Medicinal Chemistry. 59: 10676-10691. PMID 27933960 DOI: 10.1021/Acs.Jmedchem.6B01373  0.81
2016 Mereu M, Chun LE, Prisinzano T, Newman AH, Katz JL, Tanda G. The Unique Psychostimulant Profile of (±)-Modafinil: Investigation of Behavioral and Neurochemical Effects in Mice. The European Journal of Neuroscience. PMID 27545285 DOI: 10.1111/Ejn.13376  0.615
2016 Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH. Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. Journal of Medicinal Chemistry. PMID 27508895 DOI: 10.1021/Acs.Jmedchem.6B00860  0.815
2016 Zou MF, Keck TM, Kumar V, Donthamsetti P, Michino M, Burzynski C, Schweppe C, Bonifazi A, Free RB, Sibley DR, Janowsky A, Shi L, Javitch JA, Newman AH. Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. Journal of Medicinal Chemistry. PMID 27035329 DOI: 10.1021/Acs.Jmedchem.5B01612  0.793
2016 Mammoli V, Bonifazi A, Dal Ben D, Giannella M, Giorgioni G, Piergentili A, Pigini M, Quaglia W, Thomas A, Newman AH, Ferré S, Sanchez-Soto M, Keck TM, Del Bello F. A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus. Chemmedchem. PMID 26990230 DOI: 10.1002/Cmdc.201600022  0.81
2016 Sanchez-Soto M, Bonifazi A, Cai NS, Ellenberger MP, Newman AH, Ferre S, Yano H. Evidence for Non-Canonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-like Receptor Agonist. Molecular Pharmacology. PMID 26843180 DOI: 10.1124/Mol.115.101808  0.826
2016 Richardson BD, Saha K, Krout D, Cabrera E, Felts B, Henry LK, Swant J, Zou MF, Newman AH, Khoshbouei H. Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane. Nature Communications. 7: 10423. PMID 26804245 DOI: 10.1038/Ncomms10423  0.345
2016 Vuorenpää A, Jørgensen TN, Newman AH, Madsen KL, Scheinin M, Gether U. Differential internalization rates and postendocytic sorting of the norepinephrine and dopamine transporters are controlled by structural elements in the N-termini. The Journal of Biological Chemistry. PMID 26786096 DOI: 10.1074/Jbc.M115.702050  0.338
2016 Zhu R, Heilinger A, Newman AH, Freissmuth M, Sitte HH, Hinterdorfer P. Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters Biophysical Journal. 110: 9a. DOI: 10.1016/J.Bpj.2015.11.104  0.35
2015 Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang Y, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH. Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters. Molecular Pharmacology. PMID 26519222 DOI: 10.1124/Mol.115.101394  0.358
2015 Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice. Journal of Medicinal Chemistry. 58: 6195-213. PMID 26203768 DOI: 10.1021/Acs.Jmedchem.5B00776  0.814
2015 Kumar V, Yarravarapu N, Lapinsky DJ, Perley D, Felts B, Tomlinson MJ, Vaughan RA, Henry LK, Lever JR, Newman AH. Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram. Journal of Medicinal Chemistry. PMID 26153715 DOI: 10.1021/Acs.Jmedchem.5B00682  0.4
2015 Keck TM, John WS, Czoty PW, Nader MA, Newman AH. Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis. Journal of Medicinal Chemistry. PMID 25826710 DOI: 10.1021/Jm501512B  0.812
2015 Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Newman AH. Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry. 23: 4000-12. PMID 25650314 DOI: 10.1016/J.Bmc.2015.01.017  0.808
2015 Wang XF, Bi GH, He Y, Yang HJ, Gao JT, Okunola-Bakare OM, Slack RD, Gardner EL, Xi ZX, Newman AH. R-modafinil attenuates nicotine-taking and nicotine-seeking behavior in alcohol-preferring rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1762-71. PMID 25613829 DOI: 10.1038/Npp.2015.24  0.303
2015 John WS, Newman AH, Nader MA. Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys. Neuropharmacology. 92: 34-43. PMID 25576373 DOI: 10.1016/J.Neuropharm.2014.12.024  0.364
2015 Michino M, Beuming T, Donthamsetti P, Newman AH, Javitch JA, Shi L. What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Pharmacological Reviews. 67: 198-213. PMID 25527701 DOI: 10.1124/Pr.114.009944  0.343
2015 John WS, Banala AK, Newman AH, Nader MA. Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm. Psychopharmacology. 232: 1279-89. PMID 25327444 DOI: 10.1007/S00213-014-3760-6  0.538
2015 Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice Journal of Medicinal Chemistry. 58: 6195-6213. DOI: 10.1021/acs.jmedchem.5b00776  0.471
2015 Tanda G, Mereu M, Hiranita T, Newman AH, Katz J. (±)-Modafinil potentiates cocaine self-administration but not the effects on DA levels in rodents Drug and Alcohol Dependence. 146: e116. DOI: 10.1016/J.Drugalcdep.2014.09.682  0.356
2015 Martelle S, Nader SH, Czoty PW, John WS, Newman AH, Nader MA. Dopamine D3 receptor availability: Sex differences and effects of chronic drug exposure Drug and Alcohol Dependence. 146: e193-e194. DOI: 10.1016/J.Drugalcdep.2014.09.442  0.473
2015 John WS, Newman AH, Nader MA. Dopamine D2/D3 receptor modulation of food-drug choice in rhesus monkeys Drug and Alcohol Dependence. 146: e148-e149. DOI: 10.1016/J.Drugalcdep.2014.09.321  0.479
2014 Furman CA, Roof RA, Moritz AE, Miller BN, Doyle TB, Free RB, Banala AK, Paul NM, Kumar V, Sibley CD, Newman AH, Sibley DR. Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 25583363 DOI: 10.1016/J.Euroneuro.2014.11.013  0.58
2014 Dahal RA, Pramod AB, Sharma B, Krout D, Foster JD, Cha JH, Cao J, Newman AH, Lever JR, Vaughan RA, Henry LK. Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. The Journal of Biological Chemistry. 289: 29712-27. PMID 25179220 DOI: 10.1074/Jbc.M114.571521  0.465
2014 Yan Y, Newman AH, Xu M. Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. Neuroscience. 278: 154-64. PMID 25149631 DOI: 10.1016/J.Neuroscience.2014.08.008  0.486
2014 Kumar V, Rahbek-Clemmensen T, Billesbølle CB, Jorgensen TN, Gether U, Newman AH. Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. Acs Medicinal Chemistry Letters. 5: 696-9. PMID 24944746 DOI: 10.1021/Ml5000806  0.433
2014 Kumar V, Banala AK, Garcia EG, Cao J, Keck TM, Bonifazi A, Deschamps JR, Newman AH. Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66. Acs Medicinal Chemistry Letters. 5: 647-51. PMID 24944737 DOI: 10.1021/Ml500006V  0.777
2014 Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, et al. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of Clinical Investigation. 124: 3107-20. PMID 24911152 DOI: 10.1172/Jci73778  0.37
2014 Martelle SE, Nader SH, Czoty PW, John WS, Duke AN, Garg PK, Garg S, Newman AH, Nader MA. Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys. The Journal of Pharmacology and Experimental Therapeutics. 350: 205-11. PMID 24876234 DOI: 10.1124/Jpet.114.214833  0.489
2014 Kohut SJ, Hiranita T, Hong SK, Ebbs AL, Tronci V, Green J, Garcés-Ramírez L, Chun LE, Mereu M, Newman AH, Katz JL, Tanda G. Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine. Biological Psychiatry. 76: 802-9. PMID 24853388 DOI: 10.1016/J.Biopsych.2014.03.031  0.449
2014 Chen J, Levant B, Jiang C, Keck TM, Newman AH, Wang S. Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists. Journal of Medicinal Chemistry. 57: 4962-8. PMID 24848155 DOI: 10.1021/Jm401798R  0.803
2014 Baladi MG, Newman AH, Nielsen SM, Hanson GR, Fleckenstein AE. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European Journal of Pharmacology. 732: 105-10. PMID 24685638 DOI: 10.1016/J.Ejphar.2014.03.023  0.54
2014 Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. 2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter. The Journal of Pharmacology and Experimental Therapeutics. 349: 297-309. PMID 24518035 DOI: 10.1124/Jpet.113.212738  0.459
2014 Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH. Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues. Journal of Medicinal Chemistry. 57: 1000-13. PMID 24494745 DOI: 10.1021/Jm401754X  0.479
2014 Keck TM, Burzynski C, Shi L, Newman AH. Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design. Advances in Pharmacology (San Diego, Calif.). 69: 267-300. PMID 24484980 DOI: 10.1016/B978-0-12-420118-7.00007-X  0.812
2014 Baladi MG, Newman AH, France CP. Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats. Psychopharmacology. 231: 581-91. PMID 24030470 DOI: 10.1007/S00213-013-3271-X  0.373
2014 Keck TM, Zou MF, Bi GH, Zhang HY, Wang XF, Yang HJ, Srivastava R, Gardner EL, Xi ZX, Newman AH. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addiction Biology. 19: 195-209. PMID 24001208 DOI: 10.1111/Adb.12086  0.771
2014 Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. Erratum: 2-isoxazol-3-phenyltropane derivatives of cocaine: Molecular and atypical system effects at the dopamine transporter (Journal of Pharmacology and Experimental Therapeutics (2014) 349 (297-309) DOI:10.1124/jpet.113.212738) Journal of Pharmacology and Experimental Therapeutics. 349. DOI: 10.1124/Jpet.114.06Er14A  0.453
2013 Banala AK, Zhang P, Plenge P, Cyriac G, Kopajtic T, Katz JL, Loland CJ, Newman AH. Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites. Journal of Medicinal Chemistry. 56: 9709-24. PMID 24237160 DOI: 10.1021/Jm4014136  0.354
2013 Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors. Molecular Pharmacology. 84: 854-64. PMID 24061855 DOI: 10.1124/Mol.113.087833  0.588
2013 Keck TM, Yang HJ, Bi GH, Huang Y, Zhang HY, Srivastava R, Gardner EL, Newman AH, Xi ZX. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology. 229: 253-65. PMID 23615919 DOI: 10.1007/S00213-013-3106-9  0.764
2013 Tanda G, Li SM, Mereu M, Thomas AM, Ebbs AL, Chun LE, Tronci V, Green JL, Zou MF, Kopajtic TA, Newman AH, Katz JL. Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change. Psychopharmacology. 229: 307-21. PMID 23612854 DOI: 10.1007/S00213-013-3109-6  0.38
2013 Yan Y, Kong H, Wu EJ, Newman AH, Xu M. Dopamine D3 receptors regulate reconsolidation of cocaine memory. Neuroscience. 241: 32-40. PMID 23506736 DOI: 10.1016/J.Neuroscience.2013.03.005  0.507
2013 Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, et al. A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature Communications. 4: 1580. PMID 23481388 DOI: 10.1038/Ncomms2568  0.405
2013 Moreno M, Economidou D, Mar AC, López-Granero C, Caprioli D, Theobald DE, Fernando A, Newman AH, Robbins TW, Dalley JW. Divergent effects of Dâ‚‚/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats. Psychopharmacology. 228: 19-30. PMID 23407782 DOI: 10.1007/S00213-013-3010-3  0.337
2013 Zhang P, Jørgensen TN, Loland CJ, Newman AH. A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. Bioorganic & Medicinal Chemistry Letters. 23: 323-6. PMID 23168018 DOI: 10.1016/J.Bmcl.2012.10.089  0.375
2013 Rickhag M, Herborg Hansen F, Sørensen G, Nørgaard Strandfelt K, Andresen B, Gotfryd K, Madsen KL, Vestergaard Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer E, Gomeza J, Woldbye DP, Wörtwein G, et al. Erratum: Corrigendum: A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter Nature Communications. 4. DOI: 10.1038/Ncomms3589  0.344
2013 Nader MA, Duke A, Nader SH, Czoty PW, Brutcher RE, Newman AH. Long-Term Cocaine Exposure Affects Dopamine D3 Receptor Function Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 186. DOI: 10.1016/B978-0-12-800044-1.00169-0  0.392
2013 Newman AH, Banala AK, Donthamsetti P, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Drug Design for Addiction - Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 181-182. DOI: 10.1016/B978-0-12-800044-1.00163-X  0.425
2012 Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of Biological Chemistry. 287: 39316-26. PMID 23007398 DOI: 10.1074/Jbc.M112.371765  0.359
2012 Keck TM, Zou MF, Zhang P, Rutledge RP, Newman AH. Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. Acs Medicinal Chemistry Letters. 3: 544-549. PMID 22924094 DOI: 10.1021/Ml3000726  0.779
2012 Caine SB, Thomsen M, Barrett AC, Collins GT, Grundt P, Newman AH, Butler P, Xu M. Cocaine self-administration in dopamine D₃ receptor knockout mice. Experimental and Clinical Psychopharmacology. 20: 352-63. PMID 22867038 DOI: 10.1037/A0029135  0.406
2012 Newman AH, Blaylock BL, Nader MA, Bergman J, Sibley DR, Skolnick P. Medication discovery for addiction: translating the dopamine D3 receptor hypothesis. Biochemical Pharmacology. 84: 882-90. PMID 22781742 DOI: 10.1016/J.Bcp.2012.06.023  0.533
2012 Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. Journal of Medicinal Chemistry. 55: 6689-99. PMID 22632094 DOI: 10.1021/Jm300482H  0.467
2012 Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biological Psychiatry. 72: 405-13. PMID 22537794 DOI: 10.1016/J.Biopsych.2012.03.022  0.652
2012 Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P. Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells. The Journal of Biological Chemistry. 287: 105-13. PMID 22033932 DOI: 10.1074/Jbc.M111.304873  0.339
2012 Collins GT, Cunningham AR, Chen J, Wang S, Newman AH, Woods JH. Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats. Psychopharmacology. 219: 123-35. PMID 21701814 DOI: 10.1007/S00213-011-2382-5  0.314
2011 Baladi MG, Newman AH, Thomas YM, France CP. Drinking sucrose enhances quinpirole-induced yawning in rats. Behavioural Pharmacology. 22: 773-8. PMID 21979833 DOI: 10.1097/Fbp.0B013E32834D0F3C  0.383
2011 Hiranita T, Soto PL, Kohut SJ, Kopajtic T, Cao J, Newman AH, Tanda G, Katz JL. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. The Journal of Pharmacology and Experimental Therapeutics. 339: 662-77. PMID 21859929 DOI: 10.1124/Jpet.111.185025  0.353
2011 Koffarnus MN, Newman AH, Grundt P, Rice KC, Woods JH. Effects of selective dopaminergic compounds on a delay-discounting task. Behavioural Pharmacology. 22: 300-11. PMID 21694584 DOI: 10.1097/Fbp.0B013E3283473Bcb  0.558
2011 Banala AK, Levy BA, Khatri SS, Furman CA, Roof RA, Mishra Y, Griffin SA, Sibley DR, Luedtke RR, Newman AH. N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity. Journal of Medicinal Chemistry. 54: 3581-94. PMID 21495689 DOI: 10.1021/Jm200288R  0.483
2011 Zou MF, Cao J, Rodriguez AL, Conn PJ, Newman AH. Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. 21: 2650-4. PMID 21295978 DOI: 10.1016/J.Bmcl.2010.12.110  0.4
2011 Blaylock BL, Gould RW, Banala A, Grundt P, Luedtke RR, Newman AH, Nader MA. Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1104-13. PMID 21289600 DOI: 10.1038/Npp.2010.248  0.428
2011 Li SM, Kopajtic TA, O'Callaghan MJ, Agoston GE, Cao J, Newman AH, Katz JL. N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects. The Journal of Pharmacology and Experimental Therapeutics. 336: 575-85. PMID 21088247 DOI: 10.1124/Jpet.110.173260  0.498
2011 Riddle LR, Kumar R, Griffin SA, Grundt P, Newman AH, Luedtke RR. Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats. Neuropharmacology. 60: 284-94. PMID 20850462 DOI: 10.1016/j.neuropharm.2010.09.011  0.393
2011 Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 60: 182-90. PMID 20816875 DOI: 10.1016/J.Neuropharm.2010.08.021  0.472
2011 Higley AE, Spiller K, Grundt P, Newman AH, Kiefer SW, Xi ZX, Gardner EL. PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats. Journal of Psychopharmacology (Oxford, England). 25: 263-73. PMID 20142301 DOI: 10.1177/0269881109358201  0.474
2010 Cao J, Prisinzano TE, Okunola OM, Kopajtic T, Shook M, Katz JL, Newman AH. Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. Acs Medicinal Chemistry Letters. 2: 48-52. PMID 21344069 DOI: 10.1021/Ml1002025  0.629
2010 Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (New York, N.Y.). 330: 1091-5. PMID 21097933 DOI: 10.1126/Science.1197410  0.499
2010 Kopajtic TA, Liu Y, Surratt CK, Donovan DM, Newman AH, Katz JL. Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. The Journal of Pharmacology and Experimental Therapeutics. 335: 703-14. PMID 20855444 DOI: 10.1124/Jpet.110.171629  0.481
2010 Zhang P, Cyriac G, Kopajtic T, Zhao Y, Javitch JA, Katz JL, Newman AH. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of Medicinal Chemistry. 53: 6112-21. PMID 20672825 DOI: 10.1021/Jm1005034  0.452
2010 Choi JK, Mandeville JB, Chen YI, Grundt P, Sarkar SK, Newman AH, Jenkins BG. Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists. Psychopharmacology. 212: 59-72. PMID 20628733 DOI: 10.1007/S00213-010-1924-6  0.507
2010 Eriksen J, Bjørn-Yoshimoto WE, Jørgensen TN, Newman AH, Gether U. Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. The Journal of Biological Chemistry. 285: 27289-301. PMID 20551317 DOI: 10.1074/Jbc.M110.131003  0.412
2010 Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD. Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 334: 556-65. PMID 20494958 DOI: 10.1124/Jpet.110.167619  0.421
2010 Li SM, Collins GT, Paul NM, Grundt P, Newman AH, Xu M, Grandy DK, Woods JH, Katz JL. Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. Behavioural Pharmacology. 21: 171-81. PMID 20463460 DOI: 10.1097/Fbp.0B013E32833A5C68  0.622
2010 Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addiction Biology. 15: 312-23. PMID 20456290 DOI: 10.1111/J.1369-1600.2010.00211.X  0.519
2010 Zhang P, Zou MF, Rodriguez AL, Conn PJ, Newman AH. Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry. 18: 3026-35. PMID 20382541 DOI: 10.1016/J.Bmc.2010.03.053  0.438
2010 Richtand NM, Liu Y, Ahlbrand R, Sullivan JR, Newman AH, McNamara RK. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse (New York, N.Y.). 64: 634-43. PMID 20340170 DOI: 10.1002/Syn.20770  0.487
2010 Mason CW, Hassan HE, Kim KP, Cao J, Eddington ND, Newman AH, Voulalas PJ. Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse. The Journal of Pharmacology and Experimental Therapeutics. 333: 854-64. PMID 20228156 DOI: 10.1124/Jpet.109.165084  0.521
2010 Heidbreder CA, Newman AH. Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Annals of the New York Academy of Sciences. 1187: 4-34. PMID 20201845 DOI: 10.1111/j.1749-6632.2009.05149.x  0.463
2010 Taylor M, Grundt P, Griffin SA, Newman AH, Luedtke RR. Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways. Synapse (New York, N.Y.). 64: 251-66. PMID 19924694 DOI: 10.1002/syn.20725  0.473
2010 Besson M, Belin D, McNamara R, Theobald DE, Castel A, Beckett VL, Crittenden BM, Newman AH, Everitt BJ, Robbins TW, Dalley JW. Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 560-9. PMID 19847161 DOI: 10.1038/Npp.2009.162  0.497
2010 Baladi MG, Newman AH, France CP. Dopamine D3 receptors mediate the discriminative stimulus effects of quinpirole in free-feeding rats. The Journal of Pharmacology and Experimental Therapeutics. 332: 308-15. PMID 19797621 DOI: 10.1124/Jpet.109.158394  0.466
2010 SHAH JH, IZENWASSER S, GETER-DOUGLASS B, WITKIN JM, NEWMAN AH. ChemInform Abstract: (.+-.)-(N-Alkylamino)benzazepine Analogues: Novel Dopamine D1 Receptor Antagonists. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199607188  0.45
2010 SHAH JH, WITKIN JM, TELLA SR, NOWAK G, GEORGE C, NEWMAN AH. ChemInform Abstract: Quaternary Benzazepine Analogues Lack Affinity for Dopamine-D1 Receptors. Cheminform. 25: no-no. DOI: 10.1002/CHIN.199446188  0.465
2009 Tanda G, Newman AH, Katz JL. Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors. Advances in Pharmacology (San Diego, Calif.). 57: 253-89. PMID 20230764 DOI: 10.1016/S1054-3589(08)57007-4  0.459
2009 Achat-Mendes C, Platt DM, Newman AH, Spealman RD. The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys. Psychopharmacology. 206: 73-84. PMID 19513698 DOI: 10.1007/S00213-009-1581-9  0.509
2009 Tanda G, Newman AH, Ebbs AL, Tronci V, Green JL, Tallarida RJ, Katz JL. Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. The Journal of Pharmacology and Experimental Therapeutics. 330: 802-9. PMID 19483071 DOI: 10.1124/Jpet.109.154302  0.45
2009 Eriksen J, Rasmussen SG, Rasmussen TN, Vaegter CB, Cha JH, Zou MF, Newman AH, Gether U. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6794-808. PMID 19474307 DOI: 10.1523/Jneurosci.4177-08.2009  0.425
2009 Kulkarni SS, Zou MF, Cao J, Deschamps JR, Rodriguez AL, Conn PJ, Newman AH. Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists. Journal of Medicinal Chemistry. 52: 3563-75. PMID 19445453 DOI: 10.1021/Jm900172F  0.308
2009 Kumar R, Riddle L, Griffin SA, Grundt P, Newman AH, Luedtke RR. Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats. Neuropharmacology. 56: 944-55. PMID 19371585 DOI: 10.1016/j.neuropharm.2009.01.020  0.35
2009 Newman AH, Grundt P, Cyriac G, Deschamps JR, Taylor M, Kumar R, Ho D, Luedtke RR. N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. Journal of Medicinal Chemistry. 52: 2559-70. PMID 19331412 DOI: 10.1021/jm900095y  0.442
2009 Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, et al. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 329: 210-7. PMID 19136638 DOI: 10.1124/Jpet.108.144048  0.684
2009 Koffarnus MN, Greedy B, Husbands SM, Grundt P, Newman AH, Woods JH. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology. 203: 317-27. PMID 18807248 DOI: 10.1007/S00213-008-1323-4  0.364
2009 Tobin S, Newman AH, Quinn T, Shalev U. A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 217-26. PMID 18405418 DOI: 10.1017/S1461145708008778  0.493
2008 Paul NM, Taylor M, Kumar R, Deschamps JR, Luedtke RR, Newman AH. Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol. Journal of Medicinal Chemistry. 51: 6095-109. PMID 18774793 DOI: 10.1021/jm800532x  0.444
2008 Cao J, Kopajtic T, Katz JL, Newman AH. Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. Bioorganic & Medicinal Chemistry Letters. 18: 5238-41. PMID 18774292 DOI: 10.1016/J.Bmcl.2008.08.065  0.526
2008 Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature Neuroscience. 11: 780-9. PMID 18568020 DOI: 10.1038/Nn.2146  0.344
2008 Othman AA, Newman AH, Eddington ND. The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. Journal of Pharmaceutical Sciences. 97: 5453-70. PMID 18425847 DOI: 10.1002/Jps.21389  0.418
2008 Thanos PK, Michaelides M, Ho CW, Wang GJ, Newman AH, Heidbreder CA, Ashby CR, Gardner EL, Volkow ND. The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. Pharmacology, Biochemistry, and Behavior. 89: 499-507. PMID 18329700 DOI: 10.1016/J.Pbb.2008.02.003  0.374
2008 Collins GT, Calinski DM, Newman AH, Grundt P, Woods JH. Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects. The Journal of Pharmacology and Experimental Therapeutics. 325: 691-7. PMID 18305018 DOI: 10.1124/Jpet.107.133181  0.374
2008 Parnas ML, Gaffaney JD, Zou MF, Lever JR, Newman AH, Vaughan RA. Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites. Molecular Pharmacology. 73: 1141-50. PMID 18216182 DOI: 10.1124/Mol.107.043679  0.321
2008 Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL. The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats. Psychopharmacology. 196: 533-42. PMID 17985117 DOI: 10.1007/S00213-007-0986-6  0.514
2008 Loland CJ, Desai RI, Zou MF, Cao J, Grundt P, Gerstbrein K, Sitte HH, Newman AH, Katz JL, Gether U. Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular Pharmacology. 73: 813-23. PMID 17978168 DOI: 10.1124/Mol.107.039800  0.362
2008 Rothman RB, Baumann MH, Prisinzano TE, Newman AH. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochemical Pharmacology. 75: 2-16. PMID 17897630 DOI: 10.1016/J.Bcp.2007.08.007  0.654
2008 Syed SA, Newman AH, Othman AA, Eddington ND. Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse. Journal of Pharmaceutical Sciences. 97: 1993-2007. PMID 17879975 DOI: 10.1002/Jps.21123  0.469
2007 Grundt P, Prevatt KM, Cao J, Taylor M, Floresca CZ, Choi JK, Jenkins BG, Luedtke RR, Newman AH. Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. Journal of Medicinal Chemistry. 50: 4135-46. PMID 17672446 DOI: 10.1021/jm0704200  0.543
2007 Othman AA, Newman AH, Eddington ND. Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling. The Journal of Pharmacology and Experimental Therapeutics. 322: 760-9. PMID 17519385 DOI: 10.1124/Jpet.107.123315  0.458
2007 Kulkarni SS, Newman AH. Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 2987-91. PMID 17446071 DOI: 10.1016/J.Bmcl.2007.03.066  0.434
2007 Pritchard LM, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacology, Biochemistry, and Behavior. 86: 718-26. PMID 17408730 DOI: 10.1016/J.Pbb.2007.02.019  0.556
2007 Collins GT, Newman AH, Grundt P, Rice KC, Husbands SM, Chauvignac C, Chen J, Wang S, Woods JH. Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology. 193: 159-70. PMID 17393143 DOI: 10.1007/S00213-007-0766-3  0.543
2007 Kulkarni SS, Newman AH. Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 2074-9. PMID 17336520 DOI: 10.1016/J.Bmcl.2006.12.083  0.397
2007 Martelle JL, Claytor R, Ross JT, Reboussin BA, Newman AH, Nader MA. Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 321: 573-82. PMID 17272677 DOI: 10.1124/Jpet.106.113571  0.479
2007 Tanda G, Ebbs AL, Kopajtic TA, Elias LM, Campbell BL, Newman AH, Katz JL. Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 321: 334-44. PMID 17255465 DOI: 10.1124/Jpet.106.118067  0.469
2007 Grundt P, Husband SL, Luedtke RR, Taylor M, Newman AH. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorganic & Medicinal Chemistry Letters. 17: 745-9. PMID 17095222 DOI: 10.1016/j.bmcl.2006.10.076  0.446
2007 Othman AA, Syed SA, Newman AH, Eddington ND. Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. The Journal of Pharmacology and Experimental Therapeutics. 320: 344-53. PMID 17003230 DOI: 10.1124/Jpet.106.111245  0.391
2007 Newman AH, Coop A. Medicinal chemistry: New chemical classes and subtype-selective ligands Sigma Receptors: Chemistry, Cell Biology and Clinical Implications. 25-44. DOI: 10.1007/978-0-387-36514-5_2  0.535
2006 Newman AH, Cha JH, Cao J, Kopajtic T, Katz JL, Parnas ML, Vaughan R, Lever JR. Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. Journal of Medicinal Chemistry. 49: 6621-5. PMID 17064081 DOI: 10.1021/Jm0603973  0.463
2006 Zou MF, Cao J, Kopajtic T, Desai RI, Katz JL, Newman AH. Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. Journal of Medicinal Chemistry. 49: 6391-9. PMID 17034144 DOI: 10.1021/Jm060762Q  0.508
2006 Raje S, Cornish J, Newman AH, Cao J, Katz JL, Eddington ND. Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis. Biopharmaceutics & Drug Disposition. 27: 229-40. PMID 16586462 DOI: 10.1002/Bdd.497  0.411
2006 Kulkarni SS, Kopajtic TA, Katz JL, Newman AH. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorganic & Medicinal Chemistry. 14: 3625-34. PMID 16460947 DOI: 10.1016/J.Bmc.2006.01.017  0.539
2006 Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR, Gitajn L, Gardner EL. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1393-405. PMID 16205781 DOI: 10.1038/Sj.Npp.1300912  0.453
2005 Cha JH, Zou MF, Adkins EM, Rasmussen SG, Loland CJ, Schoenenberger B, Gether U, Newman AH. Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. Journal of Medicinal Chemistry. 48: 7513-6. PMID 16302792 DOI: 10.1021/Jm050431Y  0.346
2005 Grundt P, Kopajtic TA, Katz JL, Newman AH. N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorganic & Medicinal Chemistry Letters. 15: 5419-23. PMID 16213721 DOI: 10.1016/J.Bmcl.2005.08.111  0.501
2005 Campbell VC, Kopajtic TA, Newman AH, Katz JL. Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs. The Journal of Pharmacology and Experimental Therapeutics. 315: 631-40. PMID 16055673 DOI: 10.1124/Jpet.105.090829  0.473
2005 Desai RI, Kopajtic TA, French D, Newman AH, Katz JL. Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs. The Journal of Pharmacology and Experimental Therapeutics. 315: 397-404. PMID 16014753 DOI: 10.1124/Jpet.105.091231  0.45
2005 Newman AH, Grundt P, Nader MA. Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. Journal of Medicinal Chemistry. 48: 3663-79. PMID 15916415 DOI: 10.1021/Jm040190E  0.444
2005 Ukairo OT, Bondi CD, Newman AH, Kulkarni SS, Kozikowski AP, Pan S, Surratt CK. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue Journal of Pharmacology and Experimental Therapeutics. 314: 575-583. PMID 15879005 DOI: 10.1124/Jpet.105.085829  0.508
2005 Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX. Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. Synapse (New York, N.Y.). 57: 17-28. PMID 15858839 DOI: 10.1002/Syn.20152  0.364
2005 Raje S, Cornish J, Newman AH, Cao J, Katz JL, Eddington ND. Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling. Pharmaceutical Research. 22: 603-12. PMID 15846468 DOI: 10.1007/s11095-005-2488-8  0.311
2005 Collins GT, Witkin JM, Newman AH, Svensson KA, Grundt P, Cao J, Woods JH. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior. The Journal of Pharmacology and Experimental Therapeutics. 314: 310-9. PMID 15833897 DOI: 10.1124/Jpet.105.085472  0.361
2005 Li SM, Newman AH, Katz JL. Place conditioning and locomotor effects of N-substituted, 4',4''-difluorobenztropine analogs in rats. The Journal of Pharmacology and Experimental Therapeutics. 313: 1223-30. PMID 15743929 DOI: 10.1124/Jpet.105.084541  0.473
2005 Desai RI, Kopajtic TA, Koffarnus M, Newman AH, Katz JL. Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1889-93. PMID 15728828 DOI: 10.1523/Jneurosci.4778-04.2005  0.425
2005 Grundt P, Carlson EE, Cao J, Bennett CJ, McElveen E, Taylor M, Luedtke RR, Newman AH. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. Journal of Medicinal Chemistry. 48: 839-48. PMID 15689168 DOI: 10.1021/Jm049465G  0.488
2005 Tanda G, Ebbs A, Newman AH, Katz JL. Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine. The Journal of Pharmacology and Experimental Therapeutics. 313: 613-20. PMID 15681658 DOI: 10.1124/Jpet.104.080465  0.448
2004 Cao J, Lever JR, Kopajtic T, Katz JL, Pham AT, Holmes ML, Justice JB, Newman AH. Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 47: 6128-36. PMID 15566284 DOI: 10.1021/Jm049670W  0.362
2004 Truong JG, Newman AH, Hanson GR, Fleckenstein AE. Dopamine D2 receptor activation increases vesicular dopamine uptake and redistributes vesicular monoamine transporter-2 protein. European Journal of Pharmacology. 504: 27-32. PMID 15507217 DOI: 10.1016/J.Ejphar.2004.09.049  0.53
2004 Kulkarni SS, Grundt P, Kopajtic T, Katz JL, Newman AH. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. Journal of Medicinal Chemistry. 47: 3388-98. PMID 15189035 DOI: 10.1021/Jm030646C  0.433
2004 Xu L, Kulkarni SS, Izenwasser S, Katz JL, Kopajtic T, Lomenzo SA, Newman AH, Trudell ML. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. Journal of Medicinal Chemistry. 47: 1676-82. PMID 15027858 DOI: 10.1021/Jm030430A  0.356
2004 Katz JL, Kopajtic TA, Agoston GE, Newman AH. Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands. The Journal of Pharmacology and Experimental Therapeutics. 309: 650-60. PMID 14755006 DOI: 10.1124/Jpet.103.060525  0.478
2003 Raje S, Cao J, Newman AH, Gao H, Eddington ND. Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques Journal of Pharmacology and Experimental Therapeutics. 307: 801-808. PMID 12966155 DOI: 10.1124/Jpet.103.053504  0.407
2003 Zou MF, Kopajtic T, Katz JL, Newman AH. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. Journal of Medicinal Chemistry. 46: 2908-16. PMID 12825932 DOI: 10.1021/Jm0300375  0.449
2003 Cao J, Kulkarni SS, Husbands SM, Bowen WD, Williams W, Kopajtic T, Katz JL, George C, Newman AH. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of Medicinal Chemistry. 46: 2589-98. PMID 12801223 DOI: 10.1021/Jm030008U  0.549
2003 Newman AH, Cao J, Bennett CJ, Robarge MJ, Freeman RA, Luedtke RR. N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D3 receptor antagonists Bioorganic and Medicinal Chemistry Letters. 13: 2179-2183. PMID 12798330 DOI: 10.1016/S0960-894X(03)00389-5  0.589
2003 Katz JL, Libby TA, Kopajtic T, Husbands SM, Newman AH. Behavioral effects of rimcazole analogues alone and in combination with cocaine. European Journal of Pharmacology. 468: 109-19. PMID 12742518 DOI: 10.1016/S0014-2999(03)01638-8  0.334
2003 Zapata A, Gasior M, Geter-Douglass B, Tortella FC, Newman AH, Witkin JM. Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan. Pharmacology, Biochemistry, and Behavior. 74: 313-23. PMID 12479950 DOI: 10.1016/S0091-3057(02)01000-6  0.479
2002 Newman AH, Kulkarni S. Probes for the dopamine transporter: New leads toward a cocaine-abuse therapeutic - A focus on analogues of benztropine and rimcazole Medicinal Research Reviews. 22: 429-464. PMID 12210554 DOI: 10.1002/med.10014  0.395
2002 Zou MF, Agoston GE, Belov Y, Kopajtic T, Katz JL, Newman AH. Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 12: 1249-52. PMID 11965364 DOI: 10.1016/S0960-894X(02)00155-5  0.334
2001 Zou MF, Kopajtic T, Katz JL, Wirtz S, Justice JB, Newman AH. Novel tropane-based irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 44: 4453-61. PMID 11728190 DOI: 10.1021/Jm0101904  0.486
2001 Cao J, Husbands SM, Kopajtic T, Katz JL, Newman AH. [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 11: 3169-73. PMID 11720867 DOI: 10.1016/S0960-894X(01)00662-X  0.421
2001 Robarge MJ, Husbands SM, Kieltyka A, Brodbeck R, Thurkauf A, Newman AH. Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype Journal of Medicinal Chemistry. 44: 3175-3186. PMID 11543687 DOI: 10.1021/Jm010146O  0.57
2001 Woolverton WL, Hecht GS, Agoston GE, Katz JL, Newman AH. Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys. Psychopharmacology. 154: 375-82. PMID 11349390 DOI: 10.1007/S002130000616  0.41
2001 Katz JL, Agoston GE, Alling KL, Kline RH, Forster MJ, Woolverton WL, Kopajtic TA, Newman AH. Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology. 154: 362-74. PMID 11349389 DOI: 10.1007/S002130000667  0.35
2001 Newman AH, Robarge MJ, Howard IM, Wittkopp SL, George C, Kopajtic T, Izenwasser S, Katz JL. Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. Journal of Medicinal Chemistry. 44: 633-40. PMID 11170654 DOI: 10.1021/Jm000417F  0.529
2000 Hoffman BT, Kopajtic T, Katz JL, Newman AH. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. Journal of Medicinal Chemistry. 43: 4151-9. PMID 11063611 DOI: 10.1021/Jm990472S  0.446
2000 Robarge MJ, Agoston GE, Izenwasser S, Kopajtic T, George C, Katz JL, Newman AH. Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. Journal of Medicinal Chemistry. 43: 1085-93. PMID 10737741 DOI: 10.1021/Jm990265S  0.413
2000 Woolverton WL, Rowlett JK, Wilcox KM, Paul IA, Kline RH, Newman AH, Katz JL. 3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Psychopharmacology. 147: 426-35. PMID 10672637 DOI: 10.1007/S002130050012  0.471
1999 Husbands SM, Izenwasser S, Kopajtic T, Bowen WD, Vilner BJ, Katz JL, Newman AH. Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. Journal of Medicinal Chemistry. 42: 4446-55. PMID 10543888 DOI: 10.1021/Jm9902943  0.495
1999 Newman AH, Izenwasser S, Robarge MJ, Kline RH. CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter. Journal of Medicinal Chemistry. 42: 3502-9. PMID 10479283 DOI: 10.1021/Jm980701V  0.458
1999 Tolliver BK, Newman AH, Katz JL, Ho LB, Fox LM, Hsu K, Berger SP. Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. The Journal of Pharmacology and Experimental Therapeutics. 289: 110-22. PMID 10086994  0.308
1999 Vaughan RA, Agoston GE, Lever JR, Newman AH. Differential binding of tropane-based photoaffinity ligands on the dopamine transporter Journal of Neuroscience. 19: 630-636. PMID 9880583 DOI: 10.1523/Jneurosci.19-02-00630.1999  0.483
1999 Katz JL, Izenwasser S, Kline RH, Allen AC, Newman AH. Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine. The Journal of Pharmacology and Experimental Therapeutics. 288: 302-15. PMID 9862785  0.352
1999 Vaughan RA, Agoston GE, Lever JR, Newman AH. Differential Binding of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter The Journal of Neuroscience. 19: 630-636. DOI: 10.1523/JNEUROSCI.19-02-00630.1999  0.304
1998 Newman AH, Agoston GE. Novel benztropine [3α-(Diphenylmethoxy)tropane] analogs as probes for the dopamine transporter Current Medicinal Chemistry. 5: 305-319. PMID 9668197  0.407
1997 Husbands SM, Izenwasser S, Loeloff RJ, Katz JL, Bowen WD, Vilner BJ, Newman AH. Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 40: 4340-46. PMID 9435903 DOI: 10.1021/Jm9705519  0.492
1997 Agoston GE, Wu JH, Izenwasser S, George C, Katz J, Kline RH, Newman AH. Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. Journal of Medicinal Chemistry. 40: 4329-39. PMID 9435902 DOI: 10.1021/Jm970525A  0.405
1997 Katz JL, Newman AH, Izenwasser S. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, Biochemistry, and Behavior. 57: 505-12. PMID 9218275 DOI: 10.1016/S0091-3057(96)00441-8  0.393
1997 Kline RH, Izenwasser S, Katz JL, Joseph DB, Bowen WD, Newman AH. 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. Journal of Medicinal Chemistry. 40: 851-7. PMID 9083473 DOI: 10.1021/Jm950782K  0.417
1997 Agoston GE, Vaughan R, Lever JR, Izenwasser S, Terry PD, Newman AH. A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4'-fluorophenyl)methoxy]tropane Bioorganic and Medicinal Chemistry Letters. 7: 3027-3032. DOI: 10.1016/S0960-894X(97)10139-1  0.325
1996 Izenwasser S, Newman AH, Cox BM, Katz JL. The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter. European Journal of Pharmacology. 297: 9-17. PMID 8851160 DOI: 10.1016/0014-2999(95)00696-6  0.501
1996 Shah JH, Kline RH, Geter-Douglass B, Izenwasser S, Witkin JM, Newman AH. (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists. Journal of Medicinal Chemistry. 39: 3423-8. PMID 8765528 DOI: 10.1021/jm960143p  0.485
1995 Shah JH, Izenwasser S, Geter-Douglass B, Witkin JM, Newman AH. (+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists. Journal of Medicinal Chemistry. 38: 4284-93. PMID 7473556 DOI: 10.1021/JM00021A018  0.499
1994 Calderon SN, Izenwasser S, Heller B, Gutkind JS, Mattson MV, Su TP, Newman AH. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. Journal of Medicinal Chemistry. 37: 2285-91. PMID 8057277 DOI: 10.1021/JM00041A006  0.318
1992 de Costa BR, Iadarola MJ, Rothman RB, Berman KF, George C, Newman AH, Mahboubi A, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinan. Journal of Medicinal Chemistry. 35: 2826-35. PMID 1322988 DOI: 10.1021/Jm00093A016  0.506
1991 Kawai R, Carson RE, Dunn B, Newman AH, Rice KC, Blasberg RG. Regional brain measurement of Bmax and KD with the opiate antagonist cyclofoxy: equilibrium studies in the conscious rat. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11: 529-44. PMID 1646826 DOI: 10.1038/Jcbfm.1991.102  0.438
1990 Newman AH, Covington J, Oleshansky M, Jackson BW, Weissman BA, Leader H, Chiang PK. Aprophit: an irreversible antagonist for muscarinic receptors. Biochemical Pharmacology. 40: 1357-64. PMID 2403389 DOI: 10.1016/0006-2952(90)90404-9  0.357
1990 Kawai R, Sawada Y, Channing M, Newman AH, Rice KC, Blasberg RG. BBB transport and rapid tissue binding of cyclofoxy: comparison of active and inactive enantiomers. The American Journal of Physiology. 259: H1278-87. PMID 2221131 DOI: 10.1152/Ajpheart.1990.259.4.H1278  0.434
1989 Moody EJ, Mattson M, Newman AH, Rice KC, Skolnick P. Stereospecific reversal of nitrous oxide analgesia by naloxone. Life Sciences. 44: 703-9. PMID 2927240 DOI: 10.1016/0024-3205(89)90381-0  0.417
1989 McCabe RT, Schoenheimer JA, Skolnick P, Newman AH, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. Febs Letters. 244: 263-7. PMID 2537753 DOI: 10.1016/0014-5793(89)80541-1  0.428
1988 Bowen WD, Kirschner BK, Newman AH, Rice KC. σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain European Journal of Pharmacology. 149: 399-400. PMID 2842167 DOI: 10.1016/0014-2999(88)90678-4  0.504
1987 Newman AH, Lueddens HWM, Skolnick P, Rice KC. Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (±)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N-(2-isothiocyanatoethyl)-3- isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl)-2H-1,4- benzodiazepin-2-one Journal of Medicinal Chemistry. 30: 1901-1905. PMID 2821259 DOI: 10.1021/Jm00393A036  0.499
1986 Dumont R, Newman AH, Rice KC, Brossi A, Toome V, Wegrzynski B. Precursors of the mammalian synthesis of morphine: (+)-salutaridine and (-)-thebaine from (+)-6-demethylsalutaridine, and (-)-N-13CH3-thebaine from (-)-northebaine. Febs Letters. 206: 125-9. PMID 3758343 DOI: 10.1016/0014-5793(86)81353-9  0.31
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