Amy H. Newman - Publications

Affiliations: 
Medicinal Chemistry National Institutes of Health, Bethesda, MD 
Area:
G-protein coupled receptors
Website:
http://irp.drugabuse.gov/Newman.php

176 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 131: 96-103. PMID 29217282 DOI: 10.1016/j.neuropharm.2017.12.006  0.4
2016 Mereu M, Chun LE, Prisinzano T, Newman AH, Katz JL, Tanda G. The Unique Psychostimulant Profile of (±)-Modafinil: Investigation of Behavioral and Neurochemical Effects in Mice. The European Journal of Neuroscience. PMID 27545285 DOI: 10.1111/ejn.13376  0.4
2015 Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang Y, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH. Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters. Molecular Pharmacology. PMID 26519222 DOI: 10.1124/mol.115.101394  0.44
2015 Kumar V, Yarravarapu N, Lapinsky DJ, Perley D, Felts B, Tomlinson MJ, Vaughan RA, Henry LK, Lever JR, Newman AH. Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram. Journal of Medicinal Chemistry. PMID 26153715 DOI: 10.1021/acs.jmedchem.5b00682  0.96
2015 Keck TM, John WS, Czoty PW, Nader MA, Newman AH. Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis. Journal of Medicinal Chemistry. PMID 25826710 DOI: 10.1021/jm501512b  0.96
2015 Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Newman AH. Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry. 23: 4000-12. PMID 25650314 DOI: 10.1016/j.bmc.2015.01.017  0.96
2015 John WS, Newman AH, Nader MA. Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys. Neuropharmacology. 92: 34-43. PMID 25576373 DOI: 10.1016/j.neuropharm.2014.12.024  0.96
2015 John WS, Banala AK, Newman AH, Nader MA. Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm. Psychopharmacology. 232: 1279-89. PMID 25327444 DOI: 10.1007/s00213-014-3760-6  0.96
2015 Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice Journal of Medicinal Chemistry. 58: 6195-6213. DOI: 10.1021/acs.jmedchem.5b00776  0.96
2014 Furman CA, Roof RA, Moritz AE, Miller BN, Doyle TB, Free RB, Banala AK, Paul NM, Kumar V, Sibley CD, Newman AH, Sibley DR. Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 25583363 DOI: 10.1016/j.euroneuro.2014.11.013  0.96
2014 Dahal RA, Pramod AB, Sharma B, Krout D, Foster JD, Cha JH, Cao J, Newman AH, Lever JR, Vaughan RA, Henry LK. Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. The Journal of Biological Chemistry. 289: 29712-27. PMID 25179220 DOI: 10.1074/jbc.M114.571521  0.96
2014 Yan Y, Newman AH, Xu M. Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. Neuroscience. 278: 154-64. PMID 25149631 DOI: 10.1016/j.neuroscience.2014.08.008  0.96
2014 Kumar V, Rahbek-Clemmensen T, Billesbølle CB, Jorgensen TN, Gether U, Newman AH. Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. Acs Medicinal Chemistry Letters. 5: 696-9. PMID 24944746 DOI: 10.1021/ml5000806  0.96
2014 Kumar V, Banala AK, Garcia EG, Cao J, Keck TM, Bonifazi A, Deschamps JR, Newman AH. Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66. Acs Medicinal Chemistry Letters. 5: 647-51. PMID 24944737 DOI: 10.1021/ml500006v  0.96
2014 Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, et al. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of Clinical Investigation. 124: 3107-20. PMID 24911152 DOI: 10.1172/JCI73778  0.96
2014 Martelle SE, Nader SH, Czoty PW, John WS, Duke AN, Garg PK, Garg S, Newman AH, Nader MA. Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys. The Journal of Pharmacology and Experimental Therapeutics. 350: 205-11. PMID 24876234 DOI: 10.1124/jpet.114.214833  0.96
2014 Kohut SJ, Hiranita T, Hong SK, Ebbs AL, Tronci V, Green J, Garcés-Ramírez L, Chun LE, Mereu M, Newman AH, Katz JL, Tanda G. Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine. Biological Psychiatry. 76: 802-9. PMID 24853388 DOI: 10.1016/j.biopsych.2014.03.031  0.96
2014 Chen J, Levant B, Jiang C, Keck TM, Newman AH, Wang S. Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists. Journal of Medicinal Chemistry. 57: 4962-8. PMID 24848155 DOI: 10.1021/jm401798r  0.96
2014 Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. 2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter. The Journal of Pharmacology and Experimental Therapeutics. 349: 297-309. PMID 24518035 DOI: 10.1124/jpet.113.212738  0.96
2014 Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH. Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues. Journal of Medicinal Chemistry. 57: 1000-13. PMID 24494745 DOI: 10.1021/jm401754x  0.96
2014 Keck TM, Burzynski C, Shi L, Newman AH. Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design. Advances in Pharmacology (San Diego, Calif.). 69: 267-300. PMID 24484980 DOI: 10.1016/B978-0-12-420118-7.00007-X  0.96
2014 Anderluh A, Klotzsch E, Reismann AW, Brameshuber M, Kudlacek O, Newman AH, Sitte HH, Schütz GJ. Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane. The Journal of Biological Chemistry. 289: 4387-94. PMID 24394416 DOI: 10.1074/jbc.M113.531632  0.96
2014 Baladi MG, Newman AH, France CP. Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats. Psychopharmacology. 231: 581-91. PMID 24030470 DOI: 10.1007/s00213-013-3271-x  0.96
2014 Keck TM, Zou MF, Bi GH, Zhang HY, Wang XF, Yang HJ, Srivastava R, Gardner EL, Xi ZX, Newman AH. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addiction Biology. 19: 195-209. PMID 24001208 DOI: 10.1111/adb.12086  0.96
2013 Banala AK, Zhang P, Plenge P, Cyriac G, Kopajtic T, Katz JL, Loland CJ, Newman AH. Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites. Journal of Medicinal Chemistry. 56: 9709-24. PMID 24237160 DOI: 10.1021/jm4014136  0.96
2013 Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors. Molecular Pharmacology. 84: 854-64. PMID 24061855 DOI: 10.1124/mol.113.087833  0.96
2013 Mereu M, Bonci A, Newman AH, Tanda G. The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders. Psychopharmacology. 229: 415-34. PMID 23934211 DOI: 10.1007/s00213-013-3232-4  0.96
2013 Keck TM, Yang HJ, Bi GH, Huang Y, Zhang HY, Srivastava R, Gardner EL, Newman AH, Xi ZX. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology. 229: 253-65. PMID 23615919 DOI: 10.1007/s00213-013-3106-9  0.96
2013 Tanda G, Li SM, Mereu M, Thomas AM, Ebbs AL, Chun LE, Tronci V, Green JL, Zou MF, Kopajtic TA, Newman AH, Katz JL. Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change. Psychopharmacology. 229: 307-21. PMID 23612854 DOI: 10.1007/s00213-013-3109-6  0.96
2013 Yan Y, Kong H, Wu EJ, Newman AH, Xu M. Dopamine D3 receptors regulate reconsolidation of cocaine memory. Neuroscience. 241: 32-40. PMID 23506736 DOI: 10.1016/j.neuroscience.2013.03.005  0.96
2013 Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, et al. A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature Communications. 4: 1580. PMID 23481388 DOI: 10.1038/ncomms2568  0.96
2013 Moreno M, Economidou D, Mar AC, López-Granero C, Caprioli D, Theobald DE, Fernando A, Newman AH, Robbins TW, Dalley JW. Divergent effects of Dâ‚‚/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats. Psychopharmacology. 228: 19-30. PMID 23407782 DOI: 10.1007/s00213-013-3010-3  0.96
2013 Zhang P, Jørgensen TN, Loland CJ, Newman AH. A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. Bioorganic & Medicinal Chemistry Letters. 23: 323-6. PMID 23168018 DOI: 10.1016/j.bmcl.2012.10.089  0.96
2013 Li L, Hiranita T, Hayashi S, Newman AH, Katz JL. The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration. Psychopharmacology. 225: 733-42. PMID 22975727 DOI: 10.1007/s00213-012-2862-2  0.96
2013 Nader MA, Duke A, Nader SH, Czoty PW, Brutcher RE, Newman AH. Long-Term Cocaine Exposure Affects Dopamine D3 Receptor Function Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 186. DOI: 10.1016/B978-0-12-800044-1.00169-0  0.96
2013 Newman AH, Banala AK, Donthamsetti P, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Drug Design for Addiction - Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 181-182. DOI: 10.1016/B978-0-12-800044-1.00163-X  0.96
2012 Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of Biological Chemistry. 287: 39316-26. PMID 23007398 DOI: 10.1074/jbc.M112.371765  0.96
2012 Keck TM, Zou MF, Zhang P, Rutledge RP, Newman AH. Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. Acs Medicinal Chemistry Letters. 3: 544-549. PMID 22924094 DOI: 10.1021/ml3000726  0.96
2012 Caine SB, Thomsen M, Barrett AC, Collins GT, Grundt P, Newman AH, Butler P, Xu M. Cocaine self-administration in dopamine D₃ receptor knockout mice. Experimental and Clinical Psychopharmacology. 20: 352-63. PMID 22867038 DOI: 10.1037/a0029135  0.96
2012 Newman AH, Blaylock BL, Nader MA, Bergman J, Sibley DR, Skolnick P. Medication discovery for addiction: translating the dopamine D3 receptor hypothesis. Biochemical Pharmacology. 84: 882-90. PMID 22781742 DOI: 10.1016/j.bcp.2012.06.023  0.96
2012 Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. Journal of Medicinal Chemistry. 55: 6689-99. PMID 22632094 DOI: 10.1021/jm300482h  0.96
2012 Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biological Psychiatry. 72: 405-13. PMID 22537794 DOI: 10.1016/j.biopsych.2012.03.022  0.96
2012 Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P. Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells. The Journal of Biological Chemistry. 287: 105-13. PMID 22033932 DOI: 10.1074/jbc.M111.304873  0.96
2012 Fernando AB, Economidou D, Theobald DE, Zou MF, Newman AH, Spoelder M, Caprioli D, Moreno M, Hipólito L, Aspinall AT, Robbins TW, Dalley JW. Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists. Psychopharmacology. 219: 341-52. PMID 21761147 DOI: 10.1007/s00213-011-2408-z  0.96
2012 Collins GT, Cunningham AR, Chen J, Wang S, Newman AH, Woods JH. Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats. Psychopharmacology. 219: 123-35. PMID 21701814 DOI: 10.1007/s00213-011-2382-5  0.96
2011 Baladi MG, Newman AH, Thomas YM, France CP. Drinking sucrose enhances quinpirole-induced yawning in rats. Behavioural Pharmacology. 22: 773-8. PMID 21979833 DOI: 10.1097/FBP.0b013e32834d0f3c  0.96
2011 Hiranita T, Soto PL, Kohut SJ, Kopajtic T, Cao J, Newman AH, Tanda G, Katz JL. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. The Journal of Pharmacology and Experimental Therapeutics. 339: 662-77. PMID 21859929 DOI: 10.1124/jpet.111.185025  0.96
2011 Koffarnus MN, Newman AH, Grundt P, Rice KC, Woods JH. Effects of selective dopaminergic compounds on a delay-discounting task. Behavioural Pharmacology. 22: 300-11. PMID 21694584 DOI: 10.1097/FBP.0b013e3283473bcb  0.96
2011 Baladi MG, Newman AH, France CP. Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole. Psychopharmacology. 217: 573-85. PMID 21544521 DOI: 10.1007/s00213-011-2320-6  0.96
2011 Banala AK, Levy BA, Khatri SS, Furman CA, Roof RA, Mishra Y, Griffin SA, Sibley DR, Luedtke RR, Newman AH. N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity. Journal of Medicinal Chemistry. 54: 3581-94. PMID 21495689 DOI: 10.1021/jm200288r  0.96
2011 Zou MF, Cao J, Rodriguez AL, Conn PJ, Newman AH. Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. 21: 2650-4. PMID 21295978 DOI: 10.1016/j.bmcl.2010.12.110  0.96
2011 Blaylock BL, Gould RW, Banala A, Grundt P, Luedtke RR, Newman AH, Nader MA. Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1104-13. PMID 21289600 DOI: 10.1038/npp.2010.248  0.96
2011 Li SM, Kopajtic TA, O'Callaghan MJ, Agoston GE, Cao J, Newman AH, Katz JL. N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects. The Journal of Pharmacology and Experimental Therapeutics. 336: 575-85. PMID 21088247 DOI: 10.1124/jpet.110.173260  0.96
2011 Riddle LR, Kumar R, Griffin SA, Grundt P, Newman AH, Luedtke RR. Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats. Neuropharmacology. 60: 284-94. PMID 20850462 DOI: 10.1016/j.neuropharm.2010.09.011  0.96
2011 Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 60: 182-90. PMID 20816875 DOI: 10.1016/j.neuropharm.2010.08.021  0.96
2011 Higley AE, Spiller K, Grundt P, Newman AH, Kiefer SW, Xi ZX, Gardner EL. PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats. Journal of Psychopharmacology (Oxford, England). 25: 263-73. PMID 20142301 DOI: 10.1177/0269881109358201  0.44
2010 Cao J, Prisinzano TE, Okunola OM, Kopajtic T, Shook M, Katz JL, Newman AH. Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. Acs Medicinal Chemistry Letters. 2: 48-52. PMID 21344069 DOI: 10.1021/ml1002025  0.96
2010 Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (New York, N.Y.). 330: 1091-5. PMID 21097933 DOI: 10.1126/science.1197410  0.96
2010 Kopajtic TA, Liu Y, Surratt CK, Donovan DM, Newman AH, Katz JL. Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. The Journal of Pharmacology and Experimental Therapeutics. 335: 703-14. PMID 20855444 DOI: 10.1124/jpet.110.171629  0.96
2010 Zhang P, Cyriac G, Kopajtic T, Zhao Y, Javitch JA, Katz JL, Newman AH. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of Medicinal Chemistry. 53: 6112-21. PMID 20672825 DOI: 10.1021/jm1005034  0.96
2010 Choi JK, Mandeville JB, Chen YI, Grundt P, Sarkar SK, Newman AH, Jenkins BG. Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists. Psychopharmacology. 212: 59-72. PMID 20628733 DOI: 10.1007/s00213-010-1924-6  0.96
2010 Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, et al. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nature Chemical Biology. 6: 587-94. PMID 20622858 DOI: 10.1038/nchembio.396  0.96
2010 Eriksen J, Bjørn-Yoshimoto WE, Jørgensen TN, Newman AH, Gether U. Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. The Journal of Biological Chemistry. 285: 27289-301. PMID 20551317 DOI: 10.1074/jbc.M110.131003  0.96
2010 Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD. Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 334: 556-65. PMID 20494958 DOI: 10.1124/jpet.110.167619  0.96
2010 Li SM, Collins GT, Paul NM, Grundt P, Newman AH, Xu M, Grandy DK, Woods JH, Katz JL. Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. Behavioural Pharmacology. 21: 171-81. PMID 20463460 DOI: 10.1097/FBP.0b013e32833a5c68  0.96
2010 Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addiction Biology. 15: 312-23. PMID 20456290 DOI: 10.1111/j.1369-1600.2010.00211.x  0.96
2010 Zhang P, Zou MF, Rodriguez AL, Conn PJ, Newman AH. Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry. 18: 3026-35. PMID 20382541 DOI: 10.1016/j.bmc.2010.03.053  0.96
2010 Richtand NM, Liu Y, Ahlbrand R, Sullivan JR, Newman AH, McNamara RK. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse (New York, N.Y.). 64: 634-43. PMID 20340170 DOI: 10.1002/syn.20770  0.96
2010 Mason CW, Hassan HE, Kim KP, Cao J, Eddington ND, Newman AH, Voulalas PJ. Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse. The Journal of Pharmacology and Experimental Therapeutics. 333: 854-64. PMID 20228156 DOI: 10.1124/jpet.109.165084  0.96
2010 Heidbreder CA, Newman AH. Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Annals of the New York Academy of Sciences. 1187: 4-34. PMID 20201845 DOI: 10.1111/j.1749-6632.2009.05149.x  0.96
2010 Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of Biological Chemistry. 285: 10924-38. PMID 20118234 DOI: 10.1074/jbc.M109.083154  0.96
2010 Taylor M, Grundt P, Griffin SA, Newman AH, Luedtke RR. Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways. Synapse (New York, N.Y.). 64: 251-66. PMID 19924694 DOI: 10.1002/syn.20725  0.96
2010 Besson M, Belin D, McNamara R, Theobald DE, Castel A, Beckett VL, Crittenden BM, Newman AH, Everitt BJ, Robbins TW, Dalley JW. Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 560-9. PMID 19847161 DOI: 10.1038/npp.2009.162  0.96
2010 Baladi MG, Newman AH, France CP. Dopamine D3 receptors mediate the discriminative stimulus effects of quinpirole in free-feeding rats. The Journal of Pharmacology and Experimental Therapeutics. 332: 308-15. PMID 19797621 DOI: 10.1124/jpet.109.158394  0.96
2009 Tanda G, Newman AH, Katz JL. Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors. Advances in Pharmacology (San Diego, Calif.). 57: 253-89. PMID 20230764 DOI: 10.1016/S1054-3589(08)57007-4  0.96
2009 Achat-Mendes C, Platt DM, Newman AH, Spealman RD. The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys. Psychopharmacology. 206: 73-84. PMID 19513698 DOI: 10.1007/s00213-009-1581-9  0.96
2009 Tanda G, Newman AH, Ebbs AL, Tronci V, Green JL, Tallarida RJ, Katz JL. Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. The Journal of Pharmacology and Experimental Therapeutics. 330: 802-9. PMID 19483071 DOI: 10.1124/jpet.109.154302  0.96
2009 Eriksen J, Rasmussen SG, Rasmussen TN, Vaegter CB, Cha JH, Zou MF, Newman AH, Gether U. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6794-808. PMID 19474307 DOI: 10.1523/JNEUROSCI.4177-08.2009  0.96
2009 Kulkarni SS, Zou MF, Cao J, Deschamps JR, Rodriguez AL, Conn PJ, Newman AH. Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists. Journal of Medicinal Chemistry. 52: 3563-75. PMID 19445453 DOI: 10.1021/jm900172f  0.96
2009 Kumar R, Riddle L, Griffin SA, Grundt P, Newman AH, Luedtke RR. Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats. Neuropharmacology. 56: 944-55. PMID 19371585 DOI: 10.1016/j.neuropharm.2009.01.020  0.96
2009 Newman AH, Grundt P, Cyriac G, Deschamps JR, Taylor M, Kumar R, Ho D, Luedtke RR. N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. Journal of Medicinal Chemistry. 52: 2559-70. PMID 19331412 DOI: 10.1021/jm900095y  0.96
2009 Hiranita T, Soto PL, Newman AH, Katz JL. Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 329: 677-86. PMID 19228996 DOI: 10.1124/jpet.108.145813  0.96
2009 Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, et al. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 329: 210-7. PMID 19136638 DOI: 10.1124/jpet.108.144048  0.96
2009 Koffarnus MN, Greedy B, Husbands SM, Grundt P, Newman AH, Woods JH. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology. 203: 317-27. PMID 18807248 DOI: 10.1007/s00213-008-1323-4  0.96
2009 Tobin S, Newman AH, Quinn T, Shalev U. A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 217-26. PMID 18405418 DOI: 10.1017/S1461145708008778  0.96
2008 Paul NM, Taylor M, Kumar R, Deschamps JR, Luedtke RR, Newman AH. Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol. Journal of Medicinal Chemistry. 51: 6095-109. PMID 18774793 DOI: 10.1021/jm800532x  0.96
2008 Cao J, Kopajtic T, Katz JL, Newman AH. Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. Bioorganic & Medicinal Chemistry Letters. 18: 5238-41. PMID 18774292 DOI: 10.1016/j.bmcl.2008.08.065  0.96
2008 Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature Neuroscience. 11: 780-9. PMID 18568020 DOI: 10.1038/nn.2146  0.96
2008 Othman AA, Newman AH, Eddington ND. The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. Journal of Pharmaceutical Sciences. 97: 5453-70. PMID 18425847 DOI: 10.1002/jps.21389  0.96
2008 Thanos PK, Michaelides M, Ho CW, Wang GJ, Newman AH, Heidbreder CA, Ashby CR, Gardner EL, Volkow ND. The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. Pharmacology, Biochemistry, and Behavior. 89: 499-507. PMID 18329700 DOI: 10.1016/j.pbb.2008.02.003  0.96
2008 Collins GT, Calinski DM, Newman AH, Grundt P, Woods JH. Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects. The Journal of Pharmacology and Experimental Therapeutics. 325: 691-7. PMID 18305018 DOI: 10.1124/jpet.107.133181  0.96
2008 Parnas ML, Gaffaney JD, Zou MF, Lever JR, Newman AH, Vaughan RA. Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites. Molecular Pharmacology. 73: 1141-50. PMID 18216182 DOI: 10.1124/mol.107.043679  0.96
2008 Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL. The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats. Psychopharmacology. 196: 533-42. PMID 17985117 DOI: 10.1007/s00213-007-0986-6  0.96
2008 Loland CJ, Desai RI, Zou MF, Cao J, Grundt P, Gerstbrein K, Sitte HH, Newman AH, Katz JL, Gether U. Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular Pharmacology. 73: 813-23. PMID 17978168 DOI: 10.1124/mol.107.039800  0.96
2008 Rothman RB, Baumann MH, Prisinzano TE, Newman AH. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochemical Pharmacology. 75: 2-16. PMID 17897630 DOI: 10.1016/j.bcp.2007.08.007  0.96
2008 Syed SA, Newman AH, Othman AA, Eddington ND. Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse. Journal of Pharmaceutical Sciences. 97: 1993-2007. PMID 17879975 DOI: 10.1002/jps.21123  0.96
2007 Grundt P, Prevatt KM, Cao J, Taylor M, Floresca CZ, Choi JK, Jenkins BG, Luedtke RR, Newman AH. Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. Journal of Medicinal Chemistry. 50: 4135-46. PMID 17672446 DOI: 10.1021/jm0704200  0.96
2007 Othman AA, Newman AH, Eddington ND. Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling. The Journal of Pharmacology and Experimental Therapeutics. 322: 760-9. PMID 17519385 DOI: 10.1124/jpet.107.123315  0.96
2007 Kulkarni SS, Newman AH. Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 2987-91. PMID 17446071 DOI: 10.1016/j.bmcl.2007.03.066  0.96
2007 Pritchard LM, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacology, Biochemistry, and Behavior. 86: 718-26. PMID 17408730 DOI: 10.1016/j.pbb.2007.02.019  0.96
2007 Collins GT, Newman AH, Grundt P, Rice KC, Husbands SM, Chauvignac C, Chen J, Wang S, Woods JH. Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology. 193: 159-70. PMID 17393143 DOI: 10.1007/s00213-007-0766-3  0.96
2007 Kulkarni SS, Newman AH. Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 2074-9. PMID 17336520 DOI: 10.1016/j.bmcl.2006.12.083  0.96
2007 Martelle JL, Claytor R, Ross JT, Reboussin BA, Newman AH, Nader MA. Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 321: 573-82. PMID 17272677 DOI: 10.1124/jpet.106.113571  0.96
2007 Tanda G, Ebbs AL, Kopajtic TA, Elias LM, Campbell BL, Newman AH, Katz JL. Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 321: 334-44. PMID 17255465 DOI: 10.1124/jpet.106.118067  0.96
2007 Grundt P, Husband SL, Luedtke RR, Taylor M, Newman AH. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorganic & Medicinal Chemistry Letters. 17: 745-9. PMID 17095222 DOI: 10.1016/j.bmcl.2006.10.076  0.96
2007 Othman AA, Syed SA, Newman AH, Eddington ND. Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. The Journal of Pharmacology and Experimental Therapeutics. 320: 344-53. PMID 17003230 DOI: 10.1124/jpet.106.111245  0.96
2007 Newman AH, Coop A. Medicinal chemistry: New chemical classes and subtype-selective ligands Sigma Receptors: Chemistry, Cell Biology and Clinical Implications. 25-44. DOI: 10.1007/978-0-387-36514-5_2  0.96
2006 Newman AH, Cha JH, Cao J, Kopajtic T, Katz JL, Parnas ML, Vaughan R, Lever JR. Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. Journal of Medicinal Chemistry. 49: 6621-5. PMID 17064081 DOI: 10.1021/jm0603973  0.96
2006 Zou MF, Cao J, Kopajtic T, Desai RI, Katz JL, Newman AH. Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. Journal of Medicinal Chemistry. 49: 6391-9. PMID 17034144 DOI: 10.1021/jm060762q  0.96
2006 Kulkarni SS, Nightingale B, Dersch CM, Rothman RB, Newman AH. Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists Bioorganic and Medicinal Chemistry Letters. 16: 3371-3375. PMID 16678408 DOI: 10.1016/j.bmcl.2006.04.032  0.96
2006 Raje S, Cornish J, Newman AH, Cao J, Katz JL, Eddington ND. Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis. Biopharmaceutics & Drug Disposition. 27: 229-40. PMID 16586462 DOI: 10.1002/bdd.497  0.96
2006 Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proceedings of the National Academy of Sciences of the United States of America. 103: 2874-9. PMID 16477036 DOI: 10.1073/pnas.0511153103  0.96
2006 Kulkarni SS, Kopajtic TA, Katz JL, Newman AH. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorganic & Medicinal Chemistry. 14: 3625-34. PMID 16460947 DOI: 10.1016/j.bmc.2006.01.017  0.96
2006 Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, Blakely RD. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. The Journal of Biological Chemistry. 281: 2012-23. PMID 16272152 DOI: 10.1074/jbc.M505055200  0.96
2006 Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR, Gitajn L, Gardner EL. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1393-405. PMID 16205781 DOI: 10.1038/sj.npp.1300912  0.96
2005 Cha JH, Zou MF, Adkins EM, Rasmussen SG, Loland CJ, Schoenenberger B, Gether U, Newman AH. Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. Journal of Medicinal Chemistry. 48: 7513-6. PMID 16302792 DOI: 10.1021/jm050431y  0.96
2005 Grundt P, Kopajtic TA, Katz JL, Newman AH. N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorganic & Medicinal Chemistry Letters. 15: 5419-23. PMID 16213721 DOI: 10.1016/j.bmcl.2005.08.111  0.96
2005 Campbell VC, Kopajtic TA, Newman AH, Katz JL. Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs. The Journal of Pharmacology and Experimental Therapeutics. 315: 631-40. PMID 16055673 DOI: 10.1124/jpet.105.090829  0.96
2005 Desai RI, Kopajtic TA, French D, Newman AH, Katz JL. Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs. The Journal of Pharmacology and Experimental Therapeutics. 315: 397-404. PMID 16014753 DOI: 10.1124/jpet.105.091231  0.96
2005 Newman AH, Grundt P, Nader MA. Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. Journal of Medicinal Chemistry. 48: 3663-79. PMID 15916415 DOI: 10.1021/jm040190e  0.96
2005 Lever JR, Zou MF, Parnas ML, Duval RA, Wirtz SE, Justice JB, Vaughan RA, Newman AH. Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies. Bioconjugate Chemistry. 16: 644-9. PMID 15898733 DOI: 10.1021/bc0497214  0.96
2005 Ukairo OT, Bondi CD, Newman AH, Kulkarni SS, Kozikowski AP, Pan S, Surratt CK. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue Journal of Pharmacology and Experimental Therapeutics. 314: 575-583. PMID 15879005 DOI: 10.1124/jpet.105.085829  0.96
2005 Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX. Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. Synapse (New York, N.Y.). 57: 17-28. PMID 15858839 DOI: 10.1002/syn.20152  0.96
2005 Raje S, Cornish J, Newman AH, Cao J, Katz JL, Eddington ND. Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling. Pharmaceutical Research. 22: 603-12. PMID 15846468 DOI: 10.1007/s11095-005-2488-8  0.96
2005 Collins GT, Witkin JM, Newman AH, Svensson KA, Grundt P, Cao J, Woods JH. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior. The Journal of Pharmacology and Experimental Therapeutics. 314: 310-9. PMID 15833897 DOI: 10.1124/jpet.105.085472  0.96
2005 Li SM, Newman AH, Katz JL. Place conditioning and locomotor effects of N-substituted, 4',4''-difluorobenztropine analogs in rats. The Journal of Pharmacology and Experimental Therapeutics. 313: 1223-30. PMID 15743929 DOI: 10.1124/jpet.105.084541  0.96
2005 Desai RI, Kopajtic TA, Koffarnus M, Newman AH, Katz JL. Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1889-93. PMID 15728828 DOI: 10.1523/JNEUROSCI.4778-04.2005  0.96
2005 Grundt P, Carlson EE, Cao J, Bennett CJ, McElveen E, Taylor M, Luedtke RR, Newman AH. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. Journal of Medicinal Chemistry. 48: 839-48. PMID 15689168 DOI: 10.1021/jm049465g  0.96
2005 Tanda G, Ebbs A, Newman AH, Katz JL. Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine. The Journal of Pharmacology and Experimental Therapeutics. 313: 613-20. PMID 15681658 DOI: 10.1124/jpet.104.080465  0.96
2004 Cao J, Lever JR, Kopajtic T, Katz JL, Pham AT, Holmes ML, Justice JB, Newman AH. Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 47: 6128-36. PMID 15566284 DOI: 10.1021/jm049670w  0.96
2004 Truong JG, Newman AH, Hanson GR, Fleckenstein AE. Dopamine D2 receptor activation increases vesicular dopamine uptake and redistributes vesicular monoamine transporter-2 protein. European Journal of Pharmacology. 504: 27-32. PMID 15507217 DOI: 10.1016/j.ejphar.2004.09.049  0.96
2004 Kulkarni SS, Grundt P, Kopajtic T, Katz JL, Newman AH. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. Journal of Medicinal Chemistry. 47: 3388-98. PMID 15189035 DOI: 10.1021/jm030646c  0.96
2004 Grundt P, Kopajtic TA, Katz JL, Hauck Newman A. The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. Bioorganic & Medicinal Chemistry Letters. 14: 3295-8. PMID 15149693 DOI: 10.1016/j.bmcl.2004.03.075  0.96
2004 Xu L, Kulkarni SS, Izenwasser S, Katz JL, Kopajtic T, Lomenzo SA, Newman AH, Trudell ML. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. Journal of Medicinal Chemistry. 47: 1676-82. PMID 15027858 DOI: 10.1021/jm030430a  0.96
2004 Katz JL, Kopajtic TA, Agoston GE, Newman AH. Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands. The Journal of Pharmacology and Experimental Therapeutics. 309: 650-60. PMID 14755006 DOI: 10.1124/jpet.103.060525  0.96
2003 Raje S, Cao J, Newman AH, Gao H, Eddington ND. Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques Journal of Pharmacology and Experimental Therapeutics. 307: 801-808. PMID 12966155 DOI: 10.1124/jpet.103.053504  0.96
2003 Zou MF, Kopajtic T, Katz JL, Newman AH. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. Journal of Medicinal Chemistry. 46: 2908-16. PMID 12825932 DOI: 10.1021/jm0300375  0.96
2003 Cao J, Kulkarni SS, Husbands SM, Bowen WD, Williams W, Kopajtic T, Katz JL, George C, Newman AH. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of Medicinal Chemistry. 46: 2589-98. PMID 12801223 DOI: 10.1021/jm030008u  0.96
2003 Newman AH, Cao J, Bennett CJ, Robarge MJ, Freeman RA, Luedtke RR. N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D3 receptor antagonists Bioorganic and Medicinal Chemistry Letters. 13: 2179-2183. PMID 12798330 DOI: 10.1016/S0960-894X(03)00389-5  0.96
2003 Katz JL, Libby TA, Kopajtic T, Husbands SM, Newman AH. Behavioral effects of rimcazole analogues alone and in combination with cocaine. European Journal of Pharmacology. 468: 109-19. PMID 12742518 DOI: 10.1016/S0014-2999(03)01638-8  0.96
2003 Zapata A, Gasior M, Geter-Douglass B, Tortella FC, Newman AH, Witkin JM. Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan. Pharmacology, Biochemistry, and Behavior. 74: 313-23. PMID 12479950 DOI: 10.1016/S0091-3057(02)01000-6  0.96
2002 Kulkarni SS, Newman AH, Houlihan WJ. Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter Journal of Medicinal Chemistry. 45: 4119-4127. PMID 12213055 DOI: 10.1021/jm0102093  0.96
2002 Newman AH, Kulkarni S. Probes for the dopamine transporter: New leads toward a cocaine-abuse therapeutic - A focus on analogues of benztropine and rimcazole Medicinal Research Reviews. 22: 429-464. PMID 12210554 DOI: 10.1002/med.10014  0.96
2002 Brown LL, Kulkarni S, Pavlova OA, Koren AO, Mukhin AG, Newman AH, Horti AG. Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 45: 2841-9. PMID 12061886 DOI: 10.1021/jm010550n  0.96
2002 Zou MF, Agoston GE, Belov Y, Kopajtic T, Katz JL, Newman AH. Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 12: 1249-52. PMID 11965364 DOI: 10.1016/S0960-894X(02)00155-5  0.96
2001 Zou MF, Kopajtic T, Katz JL, Wirtz S, Justice JB, Newman AH. Novel tropane-based irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 44: 4453-61. PMID 11728190 DOI: 10.1021/jm0101904  0.96
2001 Cao J, Husbands SM, Kopajtic T, Katz JL, Newman AH. [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 11: 3169-73. PMID 11720867 DOI: 10.1016/S0960-894X(01)00662-X  0.96
2001 Matsumoto RR, Hewett KL, Pouw B, Bowen WD, Husbands SM, Cao JJ, Hauck Newman A. Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology. 41: 878-86. PMID 11684152 DOI: 10.1016/S0028-3908(01)00116-2  0.96
2001 Robarge MJ, Husbands SM, Kieltyka A, Brodbeck R, Thurkauf A, Newman AH. Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype Journal of Medicinal Chemistry. 44: 3175-3186. PMID 11543687 DOI: 10.1021/jm010146o  0.96
2001 Newman AH, Zou MF, Ferrer JV, Javitch JA. [3H]MFZ 2-12: a novel radioligand for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 11: 1659-61. PMID 11425531 DOI: 10.1016/S0960-894X(01)00271-2  0.96
2001 Woolverton WL, Hecht GS, Agoston GE, Katz JL, Newman AH. Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys. Psychopharmacology. 154: 375-82. PMID 11349390 DOI: 10.1007/s002130000616  0.96
2001 Katz JL, Agoston GE, Alling KL, Kline RH, Forster MJ, Woolverton WL, Kopajtic TA, Newman AH. Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology. 154: 362-74. PMID 11349389 DOI: 10.1007/s002130000667  0.96
2001 Newman AH, Robarge MJ, Howard IM, Wittkopp SL, George C, Kopajtic T, Izenwasser S, Katz JL. Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. Journal of Medicinal Chemistry. 44: 633-40. PMID 11170654 DOI: 10.1021/jm000417f  0.96
2000 Hoffman BT, Kopajtic T, Katz JL, Newman AH. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. Journal of Medicinal Chemistry. 43: 4151-9. PMID 11063611 DOI: 10.1021/jm990472s  0.96
2000 Robarge MJ, Agoston GE, Izenwasser S, Kopajtic T, George C, Katz JL, Newman AH. Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. Journal of Medicinal Chemistry. 43: 1085-93. PMID 10737741 DOI: 10.1021/jm990265s  0.96
2000 Woolverton WL, Rowlett JK, Wilcox KM, Paul IA, Kline RH, Newman AH, Katz JL. 3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Psychopharmacology. 147: 426-35. PMID 10672637  0.96
2000 Newman AH. Novel pharmacotherapies for cocaine abuse 1997-2000 Expert Opinion On Therapeutic Patents. 10: 1095-1122.  0.96
1999 Husbands SM, Izenwasser S, Kopajtic T, Bowen WD, Vilner BJ, Katz JL, Newman AH. Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. Journal of Medicinal Chemistry. 42: 4446-55. PMID 10543888 DOI: 10.1021/jm9902943  0.96
1999 Tortella FC, Britton P, Williams A, Lu XCM, Newman AH. Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist Journal of Pharmacology and Experimental Therapeutics. 291: 399-408. PMID 10490930  0.96
1999 Newman AH, Izenwasser S, Robarge MJ, Kline RH. CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter. Journal of Medicinal Chemistry. 42: 3502-9. PMID 10479283 DOI: 10.1021/jm980701v  0.96
1999 Tolliver BK, Newman AH, Katz JL, Ho LB, Fox LM, Hsu K, Berger SP. Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. The Journal of Pharmacology and Experimental Therapeutics. 289: 110-22. PMID 10086994  0.96
1999 Vaughan RA, Agoston GE, Lever JR, Newman AH. Differential binding of tropane-based photoaffinity ligands on the dopamine transporter Journal of Neuroscience. 19: 630-636. PMID 9880583  0.96
1999 Katz JL, Izenwasser S, Kline RH, Allen AC, Newman AH. Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine. The Journal of Pharmacology and Experimental Therapeutics. 288: 302-15. PMID 9862785  0.96
1998 Newman AH, Agoston GE. Novel benztropine [3α-(Diphenylmethoxy)tropane] analogs as probes for the dopamine transporter Current Medicinal Chemistry. 5: 305-319. PMID 9668197  0.96
1998 Husbands SM, Kline RH, Allen AC, Newman AH. A Diastereospecific Synthesis of 2-Methyl-5β-phenyl-5α-carbethoxy-2-azabicyclo[2.2.1]heptane: A Ring-Constrained Analogue of Meperidine Journal of Organic Chemistry. 63: 418-419.  0.96
1998 Newman AH. Novel dopamine transporter ligands: The state of the art Medicinal Chemistry Research. 8: 1-11.  0.96
1997 Husbands SM, Izenwasser S, Loeloff RJ, Katz JL, Bowen WD, Vilner BJ, Newman AH. Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. 40: 4340-46. PMID 9435903 DOI: 10.1021/jm9705519  0.96
1997 Agoston GE, Wu JH, Izenwasser S, George C, Katz J, Kline RH, Newman AH. Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. Journal of Medicinal Chemistry. 40: 4329-39. PMID 9435902 DOI: 10.1021/jm970525a  0.96
1997 Katz JL, Newman AH, Izenwasser S. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, Biochemistry, and Behavior. 57: 505-12. PMID 9218275 DOI: 10.1016/S0091-3057(96)00441-8  0.96
1997 Kline RH, Izenwasser S, Katz JL, Joseph DB, Bowen WD, Newman AH. 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. Journal of Medicinal Chemistry. 40: 851-7. PMID 9083473 DOI: 10.1021/jm950782k  0.96
1997 Agoston GE, Vaughan R, Lever JR, Izenwasser S, Terry PD, Newman AH. A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4'-fluorophenyl)methoxy]tropane Bioorganic and Medicinal Chemistry Letters. 7: 3027-3032.  0.96
1997 Tortella FC, Lu XCM, Newman AH, Britton P. AHN649: Preclinical evaluation of a novel anticonvulsant and neuroprotective analog of dextromethorphan Cns Drug Reviews. 3: 168-180.  0.96
1997 Tortella FC, Lu X-C. M, Britton P, Laskosky M, Rose J, Robles L, Decoster M, Newman AH. Post-treatment with AHN649, a novel analog of dextromethorphan,is neuroprotective and improves recovery following global forebrain ischemia in rats Pharmacology Communications. 9: 157-163.  0.96
1996 Belov YP, Aksinenko AY, Blessington B, Newman AH. Chiral aminophosphonate eluent for enantiomeric analysis of amino acids Chirality. 8: 122-125. PMID 8845275 DOI: 10.1002/(SICI)1520-636X(1996)8:1<122::AID-CHIR17>3.0.CO;2-P  0.96
1996 Izenwasser S, Newman AH, Cox BM, Katz JL. The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter Faseb Journal. 10: A448.  0.96
1996 Newman AH, Shah JH, Izenwasser S, Heller B, Mattson M, Tortella FC. Highly selective σ1 ligands based on dextromethorphan Medicinal Chemistry Research. 6: 102-117.  0.96
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