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Hans A. Kretzschmar - Publications

Affiliations: 
1992-2002 Neuropathology Georg-August-Universität Göttingen, Göttingen, Niedersachsen, Germany 
 2002-2014 Neuropathology and Prion Diseases Ludwig Maximilian University Munich, München, Bayern, Germany 
Area:
neurodegeneration, prions, neuropathology
Website:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029091/
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Year Citation  Score
2019 Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathologica. PMID 31327044 DOI: 10.1007/S00401-019-02045-5  0.722
2018 Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, et al. DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. Epigenetics & Chromatin. 11: 41. PMID 30045751 DOI: 10.1186/s13072-018-0211-3  0.635
2015 Roeber S, Müller-Sarnowski F, Kress J, Edbauer D, Kuhlmann T, Tüttelmann F, Schindler C, Winter P, Arzberger T, Müller U, Danek A, Kretzschmar HA. Three novel presenilin 1 mutations marking the wide spectrum of age at onset and clinical patterns in familial Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 26350633 DOI: 10.1007/s00702-015-1450-0  0.662
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Kretzschmar HA, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/Ncomms8247  0.569
2015 Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT, Reynolds R. Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 1055-68. PMID 25119539 DOI: 10.1007/S00702-014-1293-0  0.301
2014 Tian C, Liu D, Xiang W, Kretzschmar HA, Sun QL, Gao C, Xu Y, Wang H, Fan XY, Meng G, Li W, Dong XP. Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD). Molecular Neurobiology. 50: 473-81. PMID 24902808 DOI: 10.1007/s12035-014-8758-x  0.302
2014 Craggs LJ, Yamamoto Y, Ihara M, Fenwick R, Burke M, Oakley AE, Roeber S, Duering M, Kretzschmar H, Kalaria RN. White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Neuropathology and Applied Neurobiology. 40: 591-602. PMID 23844775 DOI: 10.1111/nan.12073  0.594
2014 Arzberger T, Mori K, Mackenzie I, Neumann M, May S, Kremmer E, Kretzschmar H, Edbauer D. EPA-1718 - Neuropathological alterations in FTD cases with C9ORF72 mutation - new insights European Psychiatry. 29: 1. DOI: 10.1016/S0924-9338(14)78857-1  0.334
2013 Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M. Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathologica. 126: 859-79. PMID 24096617 DOI: 10.1007/S00401-013-1181-Y  0.324
2013 Schelzke G, Stoeck K, Eigenbrod S, Grasbon-Frodl E, Raddatz LM, Ponto C, Kretzschmar HA, Zerr I. Report about four novel mutations in the prion protein gene. Dementia and Geriatric Cognitive Disorders. 35: 229-37. PMID 23467330 DOI: 10.1159/000345991  0.31
2013 Respondek G, Roeber S, Kretzschmar H, Troakes C, Al-Sarraj S, Gelpi E, Gaig C, Chiu WZ, van Swieten JC, Oertel WH, Höglinger GU. Accuracy of the National Institute for Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy and neuroprotection and natural history in Parkinson plus syndromes criteria for the diagnosis of progressive supranuclear palsy. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 504-9. PMID 23436751 DOI: 10.1002/mds.25327  0.624
2012 Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, ... ... Kretzschmar HA, et al. Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype. Neurobiology of Aging. 33: 2950.e5-7. PMID 22840558 DOI: 10.1016/J.Neurobiolaging.2012.07.005  0.475
2012 Schmidt C, Haïk S, Satoh K, Rábano A, Martinez-Martin P, Roeber S, Brandel JP, Calero-Lara M, de Pedro-Cuesta J, Laplanche JL, Hauw JJ, Kretzschmar H, Zerr I. Rapidly progressive Alzheimer's disease: a multicenter update. Journal of Alzheimer's Disease : Jad. 30: 751-6. PMID 22460329 DOI: 10.3233/JAD-2012-120007  0.667
2012 Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Journal of Proteome Research. 11: 2533-43. PMID 22360420 DOI: 10.1021/Pr2012279  0.64
2012 Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, Adamson J, Kouri N, Sundal C, Shuster EA, Aasly J, ... ... Kretzschmar HA, et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nature Genetics. 44: 200-5. PMID 22197934 DOI: 10.1038/Ng.1027  0.62
2011 Eigenbrod S, Roeber S, Thon N, Giese A, Krieger A, Grasbon-Frodl E, Egensperger R, Tonn JC, Kreth FW, Kretzschmar HA. α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status. Journal of Neuropathology and Experimental Neurology. 70: 970-8. PMID 22002423 DOI: 10.1097/NEN.0b013e3182333ef5  0.574
2011 Hartig MB, Iuso A, Haack T, Kmiec T, Jurkiewicz E, Heim K, Roeber S, Tarabin V, Dusi S, Krajewska-Walasek M, Jozwiak S, Hempel M, Winkelmann J, Elstner M, Oexle K, ... ... Kretzschmar H, et al. Absence of an orphan mitochondrial protein, C19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation American Journal of Human Genetics. 89: 543-550. PMID 21981780 DOI: 10.1016/j.ajhg.2011.09.007  0.662
2011 Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain : a Journal of Neurology. 134: 2595-609. PMID 21856723 DOI: 10.1093/Brain/Awr201  0.669
2011 Eigenbrod S, Frick P, Giese A, Schelzke G, Zerr I, Kretzschmar HA. Comprehensive neuropathologic analysis of genetic prion disease associated with the E196K mutation in PRNP reveals phenotypic heterogeneity. Journal of Neuropathology and Experimental Neurology. 70: 192-200. PMID 21293298 DOI: 10.1097/NEN.0b013e31820cd8a4  0.308
2011 Schelzke G, Eigenbrod S, Romero C, Varges D, Breithaupt M, Taratuto AL, Kretzschmar HA, Zerr I. Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings. Neurobiology of Aging. 32: 756.e1-9. PMID 21232818 DOI: 10.1016/j.neurobiolaging.2010.11.023  0.318
2011 Mollenhauer B, Esselmann H, Roeber S, Schulz-Schaeffer WJ, Trenkwalder C, Bibl M, Steinacker P, Kretzschmar HA, Wiltfang J, Otto M. Different CSF β-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 691-7. PMID 21210287 DOI: 10.1007/s00702-010-0543-z  0.622
2011 Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M. Distinct pathological subtypes of FTLD-FUS. Acta Neuropathologica. 121: 207-18. PMID 21052700 DOI: 10.1007/S00401-010-0764-0  0.659
2011 Capellari S, Strammiello R, Saverioni D, Kretzschmar H, Parchi P. Genetic Creutzfeldt-Jakob disease and fatal familial insomnia: insights into phenotypic variability and disease pathogenesis. Acta Neuropathologica. 121: 21-37. PMID 20978903 DOI: 10.1007/S00401-010-0760-4  0.309
2010 Parchi P, Cescatti M, Notari S, Schulz-Schaeffer WJ, Capellari S, Giese A, Zou WQ, Kretzschmar H, Ghetti B, Brown P. Agent strain variation in human prion disease: insights from a molecular and pathological review of the National Institutes of Health series of experimentally transmitted disease. Brain : a Journal of Neurology. 133: 3030-42. PMID 20823086 DOI: 10.1093/Brain/Awq234  0.302
2010 Schmidt C, Redyk K, Meissner B, Krack L, von Ahsen N, Roeber S, Kretzschmar H, Zerr I. Clinical features of rapidly progressive Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 29: 371-8. PMID 20453509 DOI: 10.1159/000278692  0.637
2009 Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain : a Journal of Neurology. 132: 2922-31. PMID 19674978 DOI: 10.1093/Brain/Awp214  0.698
2009 Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathologica. 118: 605-16. PMID 19669651 DOI: 10.1007/S00401-009-0581-5  0.672
2009 Gmitterová K, Heinemann U, Bodemer M, Krasnianski A, Meissner B, Kretzschmar HA, Zerr I. 14-3-3 CSF levels in sporadic Creutzfeldt-Jakob disease differ across molecular subtypes. Neurobiology of Aging. 30: 1842-50. PMID 18328602 DOI: 10.1016/j.neurobiolaging.2008.01.007  0.313
2008 Roeber S, Mackenzie IR, Kretzschmar HA, Neumann M. TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD. Acta Neuropathologica. 116: 147-57. PMID 18536926 DOI: 10.1007/s00401-008-0395-x  0.651
2008 Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M. Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. Journal of Neuropathology and Experimental Neurology. 67: 555-64. PMID 18520774 DOI: 10.1097/Nen.0B013E31817713B5  0.348
2008 Roeber S, Grasbon-Frodl EM, Windl O, Krebs B, Xiang W, Vollmert C, Illig T, Schröter A, Arzberger T, Weber P, Zerr I, Kretzschmar HA. Evidence for a pathogenic role of different mutations at codon 188 of PRNP. Plos One. 3: e2147. PMID 18478114 DOI: 10.1371/journal.pone.0002147  0.623
2008 Heinemann U, Krasnianski A, Meissner B, Grasbon-Frodl EM, Kretzschmar HA, Zerr I. Novel PRNP mutation in a patient with a slow progressive dementia syndrome. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 14: CS41-43. PMID 18443555  0.333
2007 Krebs B, Bader B, Klehmet J, Grasbon-Frodl E, Oertel WH, Zerr I, Stricker S, Zschenderlein R, Kretzschmar HA. A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Acta Neuropathologica. 114: 195-9. PMID 17576581 DOI: 10.1007/s00401-007-0242-5  0.347
2007 Heinemann U, Krasnianski A, Meissner B, Gloeckner SF, Kretzschmar HA, Zerr I. Molecular subtype-specific clinical diagnosis of prion diseases. Veterinary Microbiology. 123: 328-35. PMID 17513070 DOI: 10.1016/j.vetmic.2007.04.002  0.311
2007 Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. Journal of Neuropathology and Experimental Neurology. 66: 152-7. PMID 17279000 DOI: 10.1096/Fasebj.21.5.A25  0.324
2007 Sostak P, Theil D, Stepp H, Roeber S, Kretzschmar HA, Straube A. Detection of bone marrow-derived cells expressing a neural phenotype in the human brain. Journal of Neuropathology and Experimental Neurology. 66: 110-6. PMID 17278995 DOI: 10.1097/nen.0b013e3180301be8  0.584
2006 Roeber S, Bäzner H, Hennerici M, Porstmann R, Kretzschmar HA. Neurodegeneration with features of NIFID and ALS--extended clinical and neuropathological spectrum. Brain Pathology (Zurich, Switzerland). 16: 228-34. PMID 16911480 DOI: 10.1111/j.1750-3639.2006.00013.x  0.661
2006 Krasnianski A, Schulz-Schaeffer WJ, Kallenberg K, Meissner B, Collie DA, Roeber S, Bartl M, Heinemann U, Varges D, Kretzschmar HA, Zerr I. Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD. Brain : a Journal of Neurology. 129: 2288-96. PMID 16720682 DOI: 10.1093/brain/awl123  0.641
2006 de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, et al. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathologica. 111: 329-40. PMID 16552612 DOI: 10.1007/S00401-006-0048-X  0.475
2005 Roeber S, Krebs B, Neumann M, Windl O, Zerr I, Grasbon-Frodl EM, Kretzschmar HA. Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment. Acta Neuropathologica. 109: 443-8. PMID 15739100 DOI: 10.1007/s00401-004-0978-0  0.682
2004 Grasbon-Frodl E, Lorenz H, Mann U, Nitsch RM, Windl O, Kretzschmar HA. Loss of glycosylation associated with the T183A mutation in human prion disease. Acta Neuropathologica. 108: 476-84. PMID 15558291 DOI: 10.1007/s00401-004-0913-4  0.349
2003 Kretzschmar HA, Sethi S, Földvári Z, Windl O, Querner V, Zerr I, Poser S. Latrogenic Creutzfeldt-Jakob disease with florid plaques. Brain Pathology (Zurich, Switzerland). 13: 245-9. PMID 12946015  0.305
2001 Schröder B, Franz B, Hempfling P, Selbert M, Jürgens T, Kretzschmar HA, Bodemer M, Poser S, Zerr I. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. Human Genetics. 109: 319-25. PMID 11702213 DOI: 10.1007/s004390100591  0.322
2001 Neumann M, Schulz-Schaeffer W, Crowther RA, Smith MJ, Spillantini MG, Goedert M, Kretzschmar HA. Pick's disease associated with the novel Tau gene mutation K369I. Annals of Neurology. 50: 503-13. PMID 11601501 DOI: 10.1002/Ana.1223  0.321
2001 Dürig J, Giese A, Schmücker U, Kretzschmar HA, Dührsen U. Decreased prion protein expression in human peripheral blood leucocytes from patients with paroxysmal nocturnal haemoglobinuria. British Journal of Haematology. 112: 658-62. PMID 11260069 DOI: 10.1046/J.1365-2141.2001.02602.X  0.325
2001 Oehmichen M, Schulz-Schaeffer W, Kretzschmar H, Theuerkauf I, Gerling I, Windl O, Meissner C. Creutzfeldt-Jakob disease (CJD) in a case of suspected chronic heavy metal poisoning. Journal of Forensic Sciences. 46: 702-707. DOI: 10.1520/Jfs15026J  0.431
2000 Post K, Brown DR, Groschup M, Kretzschmar HA, Riesner D. Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro. Archives of Virology. Supplementum. 265-73. PMID 11214930 DOI: 10.1007/978-3-7091-6308-5_25  0.393
2000 Poser S, Zerr I, Schroeter A, Otto M, Giese A, Steinhoff BJ, Kretzschmar HA. Clinical and differential diagnosis of Creutzfeldt-Jakob disease. Archives of Virology. Supplementum. 153-9. PMID 11214918  0.36
2000 Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, Kretzschmar H, Von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Muller U. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members Journal of Neuroscience. 20: 7951-7963. PMID 11050115 DOI: 10.1523/Jneurosci.20-21-07951.2000  0.37
2000 Zerr I, Schulz-Schaeffer WJ, Giese A, Bodemer M, Schröter A, Henkel K, Tschampa HJ, Windl O, Pfahlberg A, Steinhoff BJ, Gefeller O, Kretzschmar HA, Poser S. Current clinical diagnosis in Creutzfeldt-Jakob disease: identification of uncommon variants. Annals of Neurology. 48: 323-9. PMID 10976638 DOI: 10.1002/1531-8249(200009)48:3<323::AID-ANA6>3.0.CO;2-5  0.401
2000 Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6365-73. PMID 10964942 DOI: 10.1523/Jneurosci.20-17-06365.2000  0.364
2000 Parchi P, Zou W, Wang W, Brown P, Capellari S, Ghetti B, Kopp N, Schulz-Schaeffer WJ, Kretzschmar HA, Head MW, Ironside JW, Gambetti P, Chen SG. Genetic influence on the structural variations of the abnormal prion protein. Proceedings of the National Academy of Sciences of the United States of America. 97: 10168-72. PMID 10963679 DOI: 10.1073/Pnas.97.18.10168  0.341
2000 Qin K, Yang DS, Yang Y, Chishti MA, Meng LJ, Kretzschmar HA, Yip CM, Fraser PE, Westaway D. Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation. The Journal of Biological Chemistry. 275: 19121-31. PMID 10858456 DOI: 10.1074/Jbc.275.25.19121  0.309
2000 Schulz-Schaeffer WJ, Tschöke S, Kranefuss N, Dröse W, Hause-Reitner D, Giese A, Groschup MH, Kretzschmar HA. The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases. The American Journal of Pathology. 156: 51-6. PMID 10623653 DOI: 10.1016/S0002-9440(10)64705-0  0.35
1999 Windl O, Giese A, Schulz-Schaeffer W, Zerr I, Skworc K, Arendt S, Oberdieck C, Bodemer M, Poser S, Kretzschmar HA. Molecular genetics of human prion diseases in Germany. Human Genetics. 105: 244-52. PMID 10987652 DOI: 10.1007/s004390051096  0.309
1999 Skworc KH, Windl O, Schulz-Schaeffer WJ, Giese A, Bergk J, Nägele A, Vieregge P, Zerr I, Poser S, Kretzschmar HA. Familial Creutzfeldt-Jakob disease with a novel 120-bp insertion in the prion protein gene. Annals of Neurology. 46: 693-700. PMID 10970246 DOI: 10.1002/1531-8249(199911)46:5<693::AID-ANA3>3.0.CO;2-Z  0.316
1999 Kretzschmar HA. Molecular pathogenesis of prion diseases. European Archives of Psychiatry and Clinical Neuroscience. 249: 56-63. PMID 10654101 DOI: 10.1007/Pl00014175  0.398
1999 Bürkle A, Kretzschmar HA, Brown DR. Poly(ADP-ribose) immunostaining to detect apoptosis induced by a neurotoxic fragment of prion protein. The Histochemical Journal. 31: 711-6. PMID 10646835 DOI: 10.1023/A:1003944314206  0.439
1999 Harder A, Jendroska K, Kreuz F, Wirth T, Schafranka C, Karnatz N, Théallier-Janko A, Dreier J, Lohan K, Emmerich D, Cervós-Navarro J, Windl O, Kretzschmar HA, Nürnberg P, Witkowski R. Novel twelve-generation kindred of fatal familial insomnia from germany representing the entire spectrum of disease expression. American Journal of Medical Genetics. 87: 311-6. PMID 10588836 DOI: 10.1002/(SICI)1096-8628(19991203)87:4<311::AID-AJMG6>3.0.CO;2-5  0.429
1999 Poser S, Mollenhauer B, Kraubeta A, Zerr I, Steinhoff BJ, Schroeter A, Finkenstaedt M, Schulz-Schaeffer WJ, Kretzschmar HA, Felgenhauer K. How to improve the clinical diagnosis of Creutzfeldt-Jakob disease. Brain : a Journal of Neurology. 122: 2345-51. PMID 10581227 DOI: 10.1093/brain/122.12.2345  0.307
1999 Skworc KH, Windl O, Schulz-Schaeffer WJ, Giese A, Bergk J, Nagele A, Vieregge P, Zerr I, Poser S, Kretzschmar HA. Familial Creutzfeldt-Jakob disease with a novel 120-bp insertion in the prion protein gene Annals of Neurology. 46: 693-700. PMID 10553985  0.318
1999 Samman I, Schulz-Schaeffer WJ, Wöhrle JC, Sommer A, Kretzschmar HA, Hennerici M. Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2. Journal of Neurology, Neurosurgery, and Psychiatry. 67: 678-81. PMID 10519881 DOI: 10.1136/Jnnp.67.5.678  0.344
1999 Parchi P, Giese A, Capellari S, Brown P, Schulz-Schaeffer W, Windl O, Zerr I, Budka H, Kopp N, Piccardo P, Poser S, Rojiani A, Streichemberger N, Julien J, Vital C, ... ... Kretzschmar H, et al. Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Annals of Neurology. 46: 224-33. PMID 10443888 DOI: 10.1002/1531-8249(199908)46:2<224::Aid-Ana12>3.0.Co;2-W  0.413
1999 Kropp S, Zerr I, Schulz-Schaeffer WJ, Riedemann C, Bodemer M, Laske C, Kretzschmar HA, Poser S. Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease. Neuroscience Letters. 261: 124-6. PMID 10081943 DOI: 10.1016/S0304-3940(98)00992-6  0.442
1998 Giese A, Brown DR, Groschup MH, Feldmann C, Haist I, Kretzschmar HA. Role of microglia in neuronal cell death in prion disease. Brain Pathology (Zurich, Switzerland). 8: 449-57. PMID 9669696 DOI: 10.1111/j.1750-3639.1998.tb00167.x  0.486
1998 Brown DR, Schmidt B, Kretzschmar HA. A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia. Neurobiology of Disease. 4: 410-22. PMID 9666480 DOI: 10.1006/nbdi.1998.0169  0.432
1998 Brown DR, Besinger A, Herms JW, Kretzschmar HA. Microglial expression of the prion protein. Neuroreport. 9: 1425-9. PMID 9631441 DOI: 10.1097/00001756-199805110-00032  0.359
1998 Brown DR, Kretzschmar HA. The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes. Journal of Neurocytology. 27: 109-18. PMID 9609401 DOI: 10.1023/A:1006947322342  0.324
1998 Brown DR, Schmidt B, Kretzschmar HA. Prion protein fragment interacts with PrP-deficient cells. Journal of Neuroscience Research. 52: 260-7. PMID 9590434 DOI: 10.1002/(SICI)1097-4547(19980501)52:3<260::AID-JNR2>3.0.CO;2-B  0.457
1998 Brown DR, Schmidt B, Kretzschmar HA. Effects of copper on survival of prion protein knockout neurons and glia. Journal of Neurochemistry. 70: 1686-93. PMID 9523587 DOI: 10.1046/J.1471-4159.1998.70041686.X  0.366
1998 Brown DR, Schmidt B, Groschup MH, Kretzschmar HA. Prion protein expression in muscle cells and toxicity of a prion protein fragment. European Journal of Cell Biology. 75: 29-37. PMID 9523152 DOI: 10.1016/S0171-9335(98)80043-5  0.45
1998 Zerr I, Bodemer M, Gefeller O, Otto M, Poser S, Wiltfang J, Windl O, Kretzschmar HA, Weber T. Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease. Annals of Neurology. 43: 32-40. PMID 9450766 DOI: 10.1002/Ana.410430109  0.4
1998 Brown DR, Pitschke M, Riesner D, Kretzschmar HA. Cellular effects of a neurotoxic prion protein peptide are related to its ?-sheet content Neuroscience Research Communications. 23: 119-128. DOI: 10.1002/(SICI)1520-6769(199809/10)23:2<119::AID-NRC6>3.0.CO;2-G  0.341
1997 Brown DR, Schmidt B, Kretzschmar HA. Effects of oxidative stress on prion protein expression in PC12 cells. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 15: 961-72. PMID 9641527 DOI: 10.1016/S0736-5748(97)00042-7  0.337
1997 Brown DR, Qin K, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A, Westaway D, Kretzschmar H. The cellular prion protein binds copper in vivo. Nature. 390: 684-7. PMID 9414160 DOI: 10.1038/37783  0.428
1997 Otto M, Stein H, Szudra A, Zerr I, Bodemer M, Gefeller O, Poser S, Kretzschmar HA, Mäder M, Weber T. S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Journal of Neurology. 244: 566-70. PMID 9352454 DOI: 10.1007/s004150050145  0.325
1997 Herms JW, Madlung A, Brown DR, Kretzschmar HA. Increase of intracellular free Ca2+ in microglia activated by prion protein fragment. Glia. 21: 253-7. PMID 9336239 DOI: 10.1002/(SICI)1098-1136(199710)21:2<253::AID-GLIA8>3.0.CO;2-7  0.417
1997 Brown DR, Schulz-Schaeffer WJ, Schmidt B, Kretzschmar HA. Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Experimental Neurology. 146: 104-12. PMID 9225743 DOI: 10.1006/exnr.1997.6505  0.323
1997 Brown DR, Kretzschmar HA. Microglia and prion disease: a review. Histology and Histopathology. 12: 883-92. PMID 9225170 DOI: 10.1002/jemt.1122  0.421
1997 Brown DR, Herms JW, Schmidt B, Kretzschmar HA. PrP and beta-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells. The European Journal of Neuroscience. 9: 1162-9. PMID 9215699 DOI: 10.1111/j.1460-9568.1997.tb01470.x  0.5
1997 Otto M, Wiltfang J, Tumani H, Zerr I, Lantsch M, Kornhuber J, Weber T, Kretzschmar HA, Poser S. Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neuroscience Letters. 225: 210-2. PMID 9147407 DOI: 10.1016/S0304-3940(97)00215-2  0.378
1997 Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B, Groschup M. Cell death in prion disease. Journal of Neural Transmission. Supplementum. 50: 191-210. PMID 9120419 DOI: 10.1007/978-3-7091-6842-4_19  0.394
1996 Brown DR, Schmidt B, Kretzschmar HA. A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture. Glia. 18: 59-67. PMID 8891692 DOI: 10.1002/(SICI)1098-1136(199609)18:1<59::AID-GLIA6>3.0.CO;2-Z  0.452
1996 Bergmann M, Kuchelmeister K, Schmid KW, Kretzschmar HA, Schröder R. Different variants of frontotemporal dementia: a neuropathological and immunohistochemical study. Acta Neuropathologica. 92: 170-9. PMID 8841663 DOI: 10.1007/S004010050505  0.367
1996 Zerr I, Bodemer M, Otto M, Poser S, Windl O, Kretzschmar HA, Gefeller O, Weber T. Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. Lancet. 348: 846-9. PMID 8826809 DOI: 10.1016/S0140-6736(96)08077-4  0.337
1996 Kretzschmar HA, Ironside JW, DeArmond SJ, Tateishi J. Diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Archives of Neurology. 53: 913-20. PMID 8815857 DOI: 10.1001/Archneur.1996.00550090125018  0.383
1996 Brown DR, Schmidt B, Kretzschmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature. 380: 345-7. PMID 8598929 DOI: 10.1038/380345a0  0.429
1995 Giese A, Groschup MH, Hess B, Kretzschmar HA. Neuronal cell death in scrapie-infected mice is due to apoptosis. Brain Pathology (Zurich, Switzerland). 5: 213-21. PMID 8520720 DOI: 10.1111/J.1750-3639.1995.Tb00597.X  0.351
1995 Kretzschmar HA, Neumann M, Stavrou D. Codon 178 mutation of the human prion protein gene in a German family (Backer family): sequencing data from 72-year-old celloidin-embedded brain tissue. Acta Neuropathologica. 89: 96-8. PMID 7709737 DOI: 10.1007/Bf00294264  0.316
1994 Brown DR, Herms J, Kretzschmar HA. Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment. Neuroreport. 5: 2057-60. PMID 7865744 DOI: 10.1097/00001756-199410270-00017  0.345
1994 Schumacher U, Kretzschmar H, Pfüller U. Staining of cerebral amyloid plaque glycoproteins in patients with Alzheimer's disease with the microglia-specific lectin from mistletoe. Acta Neuropathologica. 87: 422-424. PMID 7517091 DOI: 10.1007/Bf00313612  0.377
1993 Kretzschmar HA. Human prion diseases (spongiform encephalopathies). Archives of Virology. Supplementum. 7: 261-93. PMID 8219808 DOI: 10.1007/978-3-7091-9300-6_21  0.351
1992 Gabriel JM, Oesch B, Kretzschmar H, Scott M, Prusiner SB. Molecular cloning of a candidate chicken prion protein Proceedings of the National Academy of Sciences of the United States of America. 89: 9097-9101. PMID 1409608 DOI: 10.1073/PNAS.89.19.9097  0.425
1992 Kretzschmar HA, Neumann M, Riethmüller G, Prusiner SB. Molecular cloning of a mink prion protein gene. The Journal of General Virology. 2757-61. PMID 1383401 DOI: 10.1099/0022-1317-73-10-2757  0.427
1992 Kretzschmar HA, Kufer P, Riethmüller G, DeArmond S, Prusiner SB, Schiffer D. Prion protein mutation at codon 102 in an Italian family with Gerstmann-Sträussler-Scheinker syndrome. Neurology. 42: 809-10. PMID 1348851 DOI: 10.1212/WNL.42.4.809  0.407
1991 Jendroska K, Heinzel FP, Torchia M, Stowring L, Kretzschmar HA, Kon A, Stern A, Prusiner SB, DeArmond SJ. Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity. Neurology. 41: 1482-90. PMID 1679911 DOI: 10.1212/WNL.41.9.1482  0.417
1986 Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ. Molecular cloning of a human prion protein cDNA. Dna (Mary Ann Liebert, Inc.). 5: 315-24. PMID 3755672 DOI: 10.1089/DNA.1986.5.315  0.412
1986 DeArmond SJ, Lee YL, Kretzschmar HA, Eng LF. Turnover of glial filaments in mouse spinal cord. Journal of Neurochemistry. 47: 1749-53. PMID 3534142 DOI: 10.1111/j.1471-4159.1986.tb13084.x  0.434
1986 DeArmond S, Kretzschmar H, McKinley M, Barry R, Meyer R, Westaway D, Prusiner S. CHEMICAL AND BIOLOGICAL PROPERTIES OF THE PRION PROTEIN AND ITS CELLULAR ISOFORM Journal of Neuropathology and Experimental Neurology. 45: 329. DOI: 10.1097/00005072-198605000-00048  0.387
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