Simon Alford - Publications


74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hamid E, Church E, Alford S. Quantitation and simulation of single action potential-evoked Ca signals in CA1 pyramidal neuron presynaptic terminals. Eneuro. PMID 31551250 DOI: 10.1523/ENEURO.0343-19.2019  0.56
2019 Hamm HE, Alford ST. Physiological roles for neuromodulation via G GPCRs working through Gβγ-SNARE interaction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31477818 DOI: 10.1038/S41386-019-0497-2  0.6
2019 Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE. Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Science Signaling. 12. PMID 30783011 DOI: 10.1126/Scisignal.Aat8595  0.6
2019 Zurawski Z, Yim YY, Alford S, Hamm HE. The expanding roles and mechanisms of G protein-mediated presynaptic inhibition. The Journal of Biological Chemistry. 294: 1661-1670. PMID 30710014 DOI: 10.1074/Jbc.Tm118.004163  0.6
2017 Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE. Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes. The Journal of Biological Chemistry. PMID 28515322 DOI: 10.1074/Jbc.M116.773523  0.6
2016 Ryczko D, Cone JJ, Alpert MH, Goetz L, Auclair F, Dubé C, Parent M, Roitman MF, Alford S, Dubuc R. A descending dopamine pathway conserved from basal vertebrates to mammals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071118 DOI: 10.1073/Pnas.1600684113  1
2016 Daghfous G, Green WW, Alford ST, Zielinski BS, Dubuc R. Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys. Frontiers in Neural Circuits. 10: 18. PMID 27047342 DOI: 10.3389/Fncir.2016.00018  1
2015 Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE. Gβγ binds to the extreme C-terminus of SNAP25 to mediate the action of Gi/o-coupled GPCRs. Molecular Pharmacology. PMID 26519224 DOI: 10.1124/Mol.115.101600  1
2014 Ramachandran S, Alford S. Acute dissociation of lamprey reticulospinal axons to enable recording from the release face membrane of individual functional presynaptic terminals. Journal of Visualized Experiments : Jove. e51925. PMID 25350679 DOI: 10.3791/51925  1
2014 Alford ST, Alpert MH. A synaptic mechanism for network synchrony. Frontiers in Cellular Neuroscience. 8: 290. PMID 25278839 DOI: 10.3389/Fncel.2014.00290  1
2014 Hamid E, Church E, Wells CA, Zurawski Z, Hamm HE, Alford S. Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 260-74. PMID 24381287 DOI: 10.1523/Jneurosci.3633-12.2014  1
2014 Jacoby J, Kreitzer MA, Alford S, Malchow RP. Fluorescent imaging reports an extracellular alkalinization induced by glutamatergic activation of isolated retinal horizontal cells. Journal of Neurophysiology. 111: 1056-64. PMID 24335210 DOI: 10.1152/Jn.00768.2013  1
2013 Ryczko D, Grätsch S, Auclair F, Dubé C, Bergeron S, Alpert MH, Cone JJ, Roitman MF, Alford S, Dubuc R. Forebrain dopamine neurons project down to a brainstem region controlling locomotion. Proceedings of the National Academy of Sciences of the United States of America. 110: E3235-42. PMID 23918379 DOI: 10.1073/Pnas.1301125110  1
2013 Alpert MH, Alford S. Synaptic NMDA receptor-dependent Ca²⁺ entry drives membrane potential and Ca²⁺ oscillations in spinal ventral horn neurons. Plos One. 8: e63154. PMID 23646190 DOI: 10.1371/Journal.Pone.0063154  1
2013 Nanou E, Alpert MH, Alford S, El Manira A. Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network. Journal of Neurophysiology. 109: 3051-9. PMID 23554432 DOI: 10.1152/Jn.00067.2013  1
2013 Upreti C, Zhang XL, Alford S, Stanton PK. Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release. Neuropharmacology. 66: 31-9. PMID 22626985 DOI: 10.1016/J.Neuropharm.2012.05.004  1
2012 Wells CA, Zurawski Z, Betke KM, Yim YY, Hyde K, Rodriguez S, Alford S, Hamm HE. Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25. Molecular Pharmacology. 82: 1136-49. PMID 22962332 DOI: 10.1124/Mol.112.080507  1
2012 Bleckert A, Photowala H, Alford S. Dual pools of actin at presynaptic terminals. Journal of Neurophysiology. 107: 3479-92. PMID 22457456 DOI: 10.1152/jn.00789.2011  1
2012 Jacoby J, Kreitzer MA, Alford S, Qian H, Tchernookova BK, Naylor ER, Malchow RP. Extracellular pH dynamics of retinal horizontal cells examined using electrochemical and fluorometric methods. Journal of Neurophysiology. 107: 868-79. PMID 22090459 DOI: 10.1152/Jn.00878.2011  1
2012 Alford S, Brodin L. The role of NMDA receptors in synaptic integration and the organization of motor patterns The Nmda Receptor. DOI: 10.1093/acprof:oso/9780192625021.003.0012  1
2010 Chatterjea D, Hamid E, Leonard JP, Alford S. Phosphorylation-state-dependent regulation of NMDA receptor short-term plasticity modifies hippocampal dendritic Ca2+ transients. Journal of Neurophysiology. 104: 2203-13. PMID 20719921 DOI: 10.1152/jn.01081.2009  1
2010 Mussa-Ivaldi FA, Alford ST, Chiappalone M, Fadiga L, Karniel A, Kositsky M, Maggiolini E, Panzeri S, Sanguineti V, Semprini M, Vato A. New Perspectives on the Dialogue between Brains and Machines. Frontiers in Neuroscience. 4: 44. PMID 20589094 DOI: 10.3389/Neuro.01.008.2010  1
2010 Smetana R, Juvin L, Dubuc R, Alford S. A parallel cholinergic brainstem pathway for enhancing locomotor drive. Nature Neuroscience. 13: 731-8. PMID 20473293 DOI: 10.1038/Nn.2548  1
2010 Alford S, Schwartz E. Presynaptic inhibition Encyclopedia of Neuroscience. 1001-1006. DOI: 10.1016/B978-008045046-9.00814-7  1
2010 Alford S, Hamid E, Blackmer T, Gerachshenko T. Regulation of synaptic fusion by heterotrimeric G proteins Handbook of Cell Signaling, 2/E. 2: 1727-1734. DOI: 10.1016/B978-0-12-374145-5.00210-2  1
2009 Gerachshenko T, Schwartz E, Bleckert A, Photowala H, Seymour A, Alford S. Presynaptic G-protein-coupled receptors dynamically modify vesicle fusion, synaptic cleft glutamate concentrations, and motor behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10221-33. PMID 19692597 DOI: 10.1523/Jneurosci.1404-09.2009  1
2009 Kositsky M, Chiappalone M, Alford ST, Mussa-Ivaldi FA. Brain-machine interactions for assessing the dynamics of neural systems. Frontiers in Neurorobotics. 3: 1. PMID 19430593 DOI: 10.3389/neuro.12.001.2009  1
2007 Yoon EJ, Gerachshenko T, Spiegelberg BD, Alford S, Hamm HE. Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. Molecular Pharmacology. 72: 1210-9. PMID 17715396 DOI: 10.1124/Mol.107.039446  1
2007 Schwartz EJ, Blackmer T, Gerachshenko T, Alford S. Presynaptic G-protein-coupled receptors regulate synaptic cleft glutamate via transient vesicle fusion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5857-68. PMID 17537956 DOI: 10.1523/JNEUROSCI.1160-07.2007  1
2007 Smetana RW, Alford S, Dubuc R. Muscarinic receptor activation elicits sustained, recurring depolarizations in reticulospinal neurons. Journal of Neurophysiology. 97: 3181-92. PMID 17344371 DOI: 10.1152/Jn.00954.2006  1
2006 Photowala H, Blackmer T, Schwartz E, Hamm HE, Alford S. G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties. Proceedings of the National Academy of Sciences of the United States of America. 103: 4281-6. PMID 16537522 DOI: 10.1073/Pnas.0600509103  1
2005 Photowala H, Freed R, Alford S. Location and function of vesicle clusters, active zones and Ca2+ channels in the lamprey presynaptic terminal. The Journal of Physiology. 569: 119-35. PMID 16141275 DOI: 10.1113/jphysiol.2005.091314  1
2005 Karniel A, Kositsky M, Fleming KM, Chiappalone M, Sanguineti V, Alford ST, Mussa-Ivaldi FA. Computational analysis in vitro: dynamics and plasticity of a neuro-robotic system. Journal of Neural Engineering. 2: S250-65. PMID 16135888 DOI: 10.1088/1741-2560/2/3/S08  1
2005 Gerachshenko T, Blackmer T, Yoon EJ, Bartleson C, Hamm HE, Alford S. Gbetagamma acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nature Neuroscience. 8: 597-605. PMID 15834421 DOI: 10.1038/Nn1439  1
2005 Blackmer T, Larsen EC, Bartleson C, Kowalchyk JA, Yoon EJ, Preininger AM, Alford S, Hamm HE, Martin TF. G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis. Nature Neuroscience. 8: 421-5. PMID 15778713 DOI: 10.1038/Nn1423  0.84
2005 Schwartz EJ, Gerachshenko T, Alford S. 5-HT prolongs ventral root bursting via presynaptic inhibition of synaptic activity during fictive locomotion in lamprey. Journal of Neurophysiology. 93: 980-8. PMID 15456802 DOI: 10.1152/jn.00669.2004  1
2004 Viana di Prisco G, Alford S. Quantitative investigation of calcium signals for locomotor pattern generation in the lamprey spinal cord. Journal of Neurophysiology. 92: 1796-806. PMID 15140901 DOI: 10.1152/jn.00138.2004  1
2003 Alford S, Schwartz E, Viana di Prisco G. The pharmacology of vertebrate spinal central pattern generators. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 9: 217-28. PMID 15065817 DOI: 10.1177/1073858403009003014  1
2003 Kositsky M, Karniel A, Alford S, Fleming KM, Mussa-Ivaldi FA. Dynamical dimension of a hybrid neurorobotic system. Ieee Transactions On Neural Systems and Rehabilitation Engineering : a Publication of the Ieee Engineering in Medicine and Biology Society. 11: 155-9. PMID 12899261 DOI: 10.1109/TNSRE.2003.814444  1
2002 Takahashi M, Alford S. The requirement of presynaptic metabotropic glutamate receptors for the maintenance of locomotion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3692-9. PMID 11978845  1
2002 Mussa-Ivaldi FA, Karniel A, Fleming KM, Sanguineti V, Alford ST. A brain-machine system for neurobiology Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2341-2342.  1
2001 Takahashi M, Freed R, Blackmer T, Alford S. Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses. The Journal of Physiology. 532: 323-36. PMID 11306653 DOI: 10.1111/j.1469-7793.2001.0323f.x  1
2001 Blackmer T, Larsen EC, Takahashi M, Martin TF, Alford S, Hamm HE. G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entry. Science (New York, N.Y.). 292: 293-7. PMID 11303105 DOI: 10.1126/Science.1058803  1
2000 Reger BD, Fleming KM, Sanguineti V, Alford S, Mussa-Ivaldi FA. Connecting brains to robots: an artificial body for studying the computational properties of neural tissues. Artificial Life. 6: 307-24. PMID 11348584 DOI: 10.1162/106454600300103656  1
2000 Schwartz NE, Alford S. Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release. Journal of Neurophysiology. 84: 415-27. PMID 10899215 DOI: 10.1152/Jn.2000.84.1.415  1
2000 McCrimmon DR, Ramirez JM, Alford S, Zuperku EJ. Unraveling the mechanism for respiratory rhythm generation. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 22: 6-9. PMID 10649284 DOI: 10.1002/(Sici)1521-1878(200001)22:1<6::Aid-Bies3>3.0.Co;2-Q  1
1999 Kay AR, Alfonso A, Alford S, Cline HT, Holgado AM, Sakmann B, Snitsarev VA, Stricker TP, Takahashi M, Wu LG. Imaging synaptic activity in intact brain and slices with FM1-43 in C. elegans, lamprey, and rat. Neuron. 24: 809-17. PMID 10624945 DOI: 10.1016/S0896-6273(00)81029-6  1
1999 Cochilla AJ, Alford S. NMDA receptor-mediated control of presynaptic calcium and neurotransmitter release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 193-205. PMID 9870950 DOI: 10.1523/Jneurosci.19-01-00193.1999  1
1998 Chittajallu R, Alford S, Collingridge GL. Ca2+ and synaptic plasticity. Cell Calcium. 24: 377-85. PMID 10091007 DOI: 10.1016/S0143-4160(98)90061-6  1
1998 Cochilla AJ, Alford S. Metabotropic glutamate receptor-mediated control of neurotransmitter release. Neuron. 20: 1007-16. PMID 9620704 DOI: 10.1016/S0896-6273(00)80481-X  1
1998 Schwartz NE, Alford S. Modulation of pre- and postsynaptic calcium dynamics by ionotropic glutamate receptors at a plastic synapse. Journal of Neurophysiology. 79: 2191-203. PMID 9535978 DOI: 10.1152/Jn.1998.79.4.2191  1
1997 Cochilla AJ, Alford S. Glutamate receptor-mediated synaptic excitation in axons of the lamprey. The Journal of Physiology. 499: 443-57. PMID 9080373 DOI: 10.1113/Jphysiol.1997.Sp021940  1
1995 Silinsky EM, Watanabe M, Redman RS, Qiu R, Hirsh JK, Hunt JM, Solsona CS, Alford S, MacDonald RC. Neurotransmitter release evoked by nerve impulses without Ca2+ entry through Ca2+ channels in frog motor nerve endings. The Journal of Physiology. 482: 511-20. PMID 7738845  1
1995 Alford S, Zompa I, Dubuc R. Long-term potentiation of glutamatergic pathways in the lamprey brainstem. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 7528-38. PMID 7472504 DOI: 10.1523/Jneurosci.15-11-07528.1995  1
1995 Rossi DJ, Alford S, Mugnaini E, Slater NT. Properties of transmission at a giant glutamatergic synapse in cerebellum: the mossy fiber-unipolar brush cell synapse. Journal of Neurophysiology. 74: 24-42. PMID 7472327 DOI: 10.1152/Jn.1995.74.1.24  1
1993 Alford S, Frenguelli BG, Schofield JG, Collingridge GL. Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors. The Journal of Physiology. 469: 693-716. PMID 8271224 DOI: 10.1113/Jphysiol.1993.Sp019838  1
1993 Alford S, Dubuc R. Glutamate metabotropic receptor mediated depression of synaptic inputs to lamprey reticulospinal neurones. Brain Research. 605: 175-9. PMID 8096788 DOI: 10.1016/0006-8993(93)91370-8  1
1993 Frenguelli BG, Potier B, Slater NT, Alford S, Collingridge GL. Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones. Neuropharmacology. 32: 1229-37. PMID 7906405 DOI: 10.1016/0028-3908(93)90017-W  0.96
1992 Collingridge GL, Randall AD, Davies CH, Alford S. The synaptic activation of NMDA receptors and Ca2+ signalling in neurons. Ciba Foundation Symposium. 164: 162-71; discussion 1. PMID 1327677  1
1991 Bashir ZI, Alford S, Davies SN, Randall AD, Collingridge GL. Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature. 349: 156-8. PMID 1846031 DOI: 10.1038/349156a0  1
1991 Christenson J, Alford S, Grillner S, Hökfelt T. Co-localized GABA and somatostatin use different ionic mechanisms to hyperpolarize target neurons in the lamprey spinal cord. Neuroscience Letters. 134: 93-7. PMID 1687706 DOI: 10.1016/0304-3940(91)90516-V  1
1991 Alford S, Grillner S. The involvement of GABAB receptors and coupled G-proteins in spinal GABAergic presynaptic inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3718-26. PMID 1660534  1
1991 Alford S, Collingridge GL. Simultaneous whole-cell patch-clamp recording and imaging of single pyramidal neurones in rat hippocampal slices Journal of Physiology. 435: 5P.  1
1991 Alford S, Christenson J, Grillner S. Presynaptic GABA(A) and GABA(B) receptor-mediated phasic modulation in axons of spinal motor interneurons European Journal of Neuroscience. 3: 107-117.  1
1991 Alford S, Collingridge GL. Somatic Ca2+ entry following repetitive synaptic stimulus in patch-clamped CA1 pyramidal neurones in rat hippocampal slices Journal of Physiology. 435: 44P.  1
1990 Alford S, Sigvardt KA, Williams TL. GABAergic control of rhythmic activity in the presence of strychnine in the lamprey spinal cord. Brain Research. 506: 303-6. PMID 2302569 DOI: 10.1016/0006-8993(90)91267-K  1
1990 Alford S, Williams TL, Sigvardt KA. Effects of bicuculline and strychnine on synaptic inputs to edge cells during fictive locomotion. Brain Research. 509: 137-40. PMID 2155043 DOI: 10.1016/0006-8993(90)90320-B  1
1990 Alford S, Grillner S. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Research. 506: 297-302. PMID 1967966 DOI: 10.1016/0006-8993(90)91266-J  1
1990 Alford S, Grillner S. GABA(B) receptor-mediated presynaptic modulation is due to a G protein-coupled mechanism in isolated spinal cord of the lamprey, I. unicuspis Journal of Physiology. 426: 53P.  1
1989 Alford S, Williams TL. Endogenous activation of glycine and NMDA receptors in lamprey spinal cord during fictive locomotion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 2792-800. PMID 2549218  1
1989 Alford S, Sigvardt KA. Excitatory neurotransmission activates voltage-dependent properties in neurons in spinal motor system of lamprey. Journal of Neurophysiology. 62: 334-41. PMID 2549207 DOI: 10.1152/Jn.1989.62.2.334  1
1988 Davies SN, Alford ST, Coan EJ, Lester RA, Collingridge GL. Ketamine blocks an NMDA receptor-mediated component of synaptic transmission in rat hippocampus in a voltage-dependent manner. Neuroscience Letters. 92: 213-7. PMID 2903476 DOI: 10.1016/0304-3940(88)90063-8  1
1987 Alford S, Williams TL. Inhibitory synaptic input to edge cells during fictive locomotion. Brain Research. 409: 139-42. PMID 3580862 DOI: 10.1016/0006-8993(87)90749-9  1
1986 Roberts A, Alford ST. Descending projections and excitation during fictive swimming in Xenopus embryos: neuroanatomy and lesion experiments. The Journal of Comparative Neurology. 250: 253-61. PMID 3745515 DOI: 10.1002/Cne.902500212  1
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