Javier Blesa, Ph.D. - Publications

Affiliations: 
Neurociencias CIMA, Universidad de Navarra, Pamplona, Navarra, Spain 

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Balzano T, Pineda-Pardo JA, Esteban-García N, López-Aguirre M, Reinares-Sebastián A, Trigo-Damas I, Takada M, Obeso JA, Blesa J. Temporal dynamics of neurovascular unit changes following blood-brain barrier opening in the putamen of non-human primates. Journal of Controlled Release : Official Journal of the Controlled Release Society. 377: 116-126. PMID 39547418 DOI: 10.1016/j.jconrel.2024.11.019  0.368
2024 Del Rey NL, Hernández-Pinedo N, Carrillo M, Del Cerro M, Esteban-García N, Trigo-Damas I, Monje MHG, Lanciego JL, Cavada C, Obeso JA, Blesa J. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model. Npj Parkinson's Disease. 10: 165. PMID 39223183 DOI: 10.1038/s41531-024-00777-0  0.473
2024 Balzano T, Del Rey NL, Esteban-García N, Reinares-Sebastián A, Pineda-Pardo JA, Trigo-Damas I, Obeso JA, Blesa J. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. Npj Parkinson's Disease. 10: 118. PMID 38886348 DOI: 10.1038/s41531-024-00735-w  0.57
2024 Gasca-Salas C, Pineda-Pardo JA, Del Álamo M, Jiménez T, Trompeta C, Toltsis G, Garcia-Cañamaque L, Fernández-Rodríguez B, Matarazzo M, Plaza de Las Heras I, Natera-Villalba E, Martínez-Fernández R, Duque A, Ruiz de Aguiar S, Blesa J, et al. Nigrostriatal blood-brain barrier opening in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 38760152 DOI: 10.1136/jnnp-2023-332967  0.576
2024 Fernández-Calvet A, Matilla-Cuenca L, Izco M, Navarro S, Serrano M, Ventura S, Blesa J, Herráiz M, Alkorta-Aranburu G, Galera S, Ruiz de Los Mozos I, Mansego ML, Toledo-Arana A, Alvarez-Erviti L, Valle J. Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration. Nature Communications. 15: 4150. PMID 38755164 DOI: 10.1038/s41467-024-48309-x  0.3
2023 Blesa J, Pineda-Pardo JA, Inoue KI, Gasca-Salas C, Balzano T, Del Rey NL, Reinares-Sebastián A, Esteban-García N, Rodríguez-Rojas R, Márquez R, Ciorraga M, Del Álamo M, García-Cañamaque L, Ruiz de Aguiar S, Rachmilevitch I, et al. BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging. Science Advances. 9: eadf4888. PMID 37075119 DOI: 10.1126/sciadv.adf4888  0.474
2022 Balzano T, Esteban-García N, Blesa J. Neuroinflammation, immune response and α-synuclein pathology: how animal models are helping us to connect dots. Expert Opinion On Drug Discovery. 18: 13-23. PMID 36538833 DOI: 10.1080/17460441.2023.2160440  0.402
2022 Pineda-Pardo JA, Gasca-Salas C, Fernández-Rodríguez B, Rodríguez-Rojas R, Del Álamo M, Obeso I, Hernández-Fernández F, Trompeta C, Martínez-Fernández R, Matarazzo M, Mata-Marín D, Guida P, Duque A, Albillo D, Plaza de Las Heras I, ... ... Blesa J, et al. Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35765711 DOI: 10.1002/mds.29134  0.596
2022 Del Rey NL, Trigo-Damas I, Obeso JA, Cavada C, Blesa J. Neuron types in the primate striatum: Stereological analysis of projection neurons and interneurons in control and parkinsonian monkeys. Neuropathology and Applied Neurobiology. e12812. PMID 35274336 DOI: 10.1111/nan.12812  0.446
2022 Molinet-Dronda F, Blesa J, Del Rey NL, Juri C, Collantes M, Pineda-Pardo JA, Trigo-Damas I, Iglesias E, Hernández LF, Rodríguez-Rojas R, Gago B, Ecay M, Prieto E, García-Cabezas MÁ, Cavada C, et al. Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism. Neurobiology of Disease. 167: 105669. PMID 35219857 DOI: 10.1016/j.nbd.2022.105669  0.768
2021 Blesa J, Foffani G, Dehay B, Bezard E, Obeso JA. Motor and non-motor circuit disturbances in early Parkinson disease: which happens first? Nature Reviews. Neuroscience. PMID 34907352 DOI: 10.1038/s41583-021-00542-9  0.662
2021 Del Rey NL, Balzano T, Martin-Rodriguez L, Salinas-Rebolledo C, Trigo-Damas I, Rojas-Fernandez A, Alvarez-Erviti L, Blesa J. Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala. Frontiers in Aging Neuroscience. 13: 698979. PMID 34744683 DOI: 10.3389/fnagi.2021.698979  0.432
2021 Izco M, Vettorazzi A, Forcen R, Blesa J, de Toro M, Alvarez-Herrera N, Cooper JM, Gonzalez-Peñas E, Lopez de Cerain A, Alvarez-Erviti L. Oral subchronic exposure to the mycotoxin ochratoxin A induces key pathological features of Parkinson´s disease in mice six months after the end of the treatment. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112164. PMID 33819549 DOI: 10.1016/j.fct.2021.112164  0.406
2019 Monje MHG, Blesa J, García-Cabezas MÁ, Obeso JA, Cavada C. Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31800134 DOI: 10.1002/Mds.27921  0.684
2019 Jiménez-Sánchez L, Blesa J, Del Rey NL, Monje MH, Obeso JA, Cavada C. Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease. Neuropharmacology. 107806. PMID 31589886 DOI: 10.1016/J.Neuropharm.2019.107806  0.653
2019 Izco M, Blesa J, Schleef M, Schmeer M, Porcari R, Al-Shawi R, Ellmerich S, de Toro M, Gardiner C, Seow Y, Reinares-Sebastian A, Forcen R, Simons JP, Bellotti V, Cooper JM, et al. Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31501034 DOI: 10.1016/J.Ymthe.2019.08.010  0.352
2019 Foffani G, Trigo-Damas I, Pineda-Pardo JA, Blesa J, Rodríguez-Rojas R, Martínez-Fernández R, Obeso JA. Focused ultrasound in Parkinson's disease: A twofold path toward disease modification. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31412430 DOI: 10.1002/Mds.27805  0.658
2019 Karakatsani ME, Blesa J, Konofagou EE. Blood-brain barrier opening with focused ultrasound in experimental models of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31361356 DOI: 10.1002/Mds.27804  0.509
2019 Blesa J, Vila M. Parkinson disease, substantia nigra vulnerability, and calbindin expression: Enlightening the darkness? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30675930 DOI: 10.1002/Mds.27618  0.486
2018 Del Rey NL, Quiroga-Varela A, Garbayo E, Carballo-Carbajal I, Fernández-Santiago R, Monje MHG, Trigo-Damas I, Blanco-Prieto MJ, Blesa J. Advances in Parkinson's Disease: 200 Years Later. Frontiers in Neuroanatomy. 12: 113. PMID 30618654 DOI: 10.3389/Fnana.2018.00113  0.418
2018 Trigo-Damas I, Del Rey NL, Blesa J. Novel models for Parkinson's disease and their impact on future drug discovery. Expert Opinion On Drug Discovery. 1-11. PMID 29363335 DOI: 10.1080/17460441.2018.1428556  0.471
2017 Blesa J, Trigo-Damas I, Dileone M, Del Rey NL, Hernandez LF, Obeso JA. Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification. Experimental Neurology. PMID 28987461 DOI: 10.1016/J.Expneurol.2017.10.002  0.82
2017 Pifl C, Reither H, Del Rey NL, Cavada C, Obeso JA, Blesa J. Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys. Frontiers in Neuroanatomy. 11: 46. PMID 28611598 DOI: 10.3389/Fnana.2017.00046  0.713
2017 Blesa J, Trigo-Damas I, Del Rey NL, Obeso JA. The use of nonhuman primate models to understand processes in Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 28357564 DOI: 10.1007/S00702-017-1715-X  0.69
2017 Del Rey NL, Blesa J. Parkinson's disease: Oh my gut! Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28151555 DOI: 10.1002/Mds.26933  0.461
2016 Blesa J, Trigo-Damas I, Obeso JA. Parkinson's disease and thalamus: facts and fancy. The Lancet. Neurology. 15: e2. PMID 27302241 DOI: 10.1016/S1474-4422(16)30048-5  0.61
2016 Del Rey NL, Blesa J. Selective connectivity of dopamine neurons projecting to the posterior striatum. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26861629 DOI: 10.1002/Mds.26496  0.405
2015 Blesa J. Vive la difference! Dissecting the diversity of midbrain dopamine neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26686701 DOI: 10.1002/Mds.26487  0.409
2015 Blesa J, Lanciego JL, Obeso JA. Editorial: Parkinson's disease: cell vulnerability and disease progression. Frontiers in Neuroanatomy. 9: 125. PMID 26441555 DOI: 10.3389/Fnana.2015.00125  0.672
2015 Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR. Oxidative stress and Parkinson's disease. Frontiers in Neuroanatomy. 9: 91. PMID 26217195 DOI: 10.3389/Fnana.2015.00091  0.552
2015 Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nature Neuroscience. PMID 26214373 DOI: 10.1038/Nn.4070  0.325
2015 Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5724-42. PMID 25855184 DOI: 10.1523/Jneurosci.0632-14.2015  0.499
2014 Blesa J, Przedborski S. Parkinson's disease: animal models and dopaminergic cell vulnerability. Frontiers in Neuroanatomy. 8: 155. PMID 25565980 DOI: 10.3389/Fnana.2014.00155  0.592
2014 Blesa J. VMAT2 and Parkinson's disease: old dog, new tricks. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1241. PMID 25124053 DOI: 10.1002/Mds.25986  0.574
2014 Pifl C, Rajput A, Reither H, Blesa J, Cavada C, Obeso JA, Rajput AH, Hornykiewicz O. Is Parkinson's disease a vesicular dopamine storage disorder? Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8210-8. PMID 24920625 DOI: 10.1523/Jneurosci.5456-13.2014  0.683
2014 Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez-Villalba A, Fernagut PO, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bezard E, Vila M. Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys. Annals of Neurology. 75: 351-62. PMID 24243558 DOI: 10.1002/Ana.24066  0.663
2013 Blesa J. Parkinson's disease: "Braak" to the future. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1209. PMID 23939718 DOI: 10.1002/Mds.25498  0.519
2013 Pifl C, Hornykiewicz O, Blesa J, Adánez R, Cavada C, Obeso JA. Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of parkinsonism. Journal of Neurochemistry. 125: 657-62. PMID 23331162 DOI: 10.1111/Jnc.12162  0.734
2012 Gonzalez-Reyes LE, Verbitsky M, Blesa J, Jackson-Lewis V, Paredes D, Tillack K, Phani S, Kramer ER, Przedborski S, Kottmann AH. Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron. 75: 306-19. PMID 22841315 DOI: 10.1016/J.Neuron.2012.05.018  0.468
2012 Blesa J, Pifl C, Sánchez-González MA, Juri C, García-Cabezas MA, Adánez R, Iglesias E, Collantes M, Peñuelas I, Sánchez-Hernández JJ, Rodríguez-Oroz MC, Avendaño C, Hornykiewicz O, Cavada C, Obeso JA. The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: a PET, histological and biochemical study. Neurobiology of Disease. 48: 79-91. PMID 22677034 DOI: 10.1016/J.Nbd.2012.05.018  0.759
2012 Blesa J, Phani S, Jackson-Lewis V, Przedborski S. Classic and new animal models of Parkinson's disease. Journal of Biomedicine & Biotechnology. 2012: 845618. PMID 22536024 DOI: 10.1155/2012/845618  0.524
2012 Jackson-Lewis V, Blesa J, Przedborski S. Animal models of Parkinson's disease. Parkinsonism & Related Disorders. 18: S183-5. PMID 22166429 DOI: 10.1016/S1353-8020(11)70057-8  0.512
2011 Blesa J, Juri C, García-Cabezas MÁ, Adánez R, Sánchez-González MÁ, Cavada C, Obeso JA. Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: a possible compensatory mechanism in Parkinson's disease. Frontiers in Systems Neuroscience. 5: 92. PMID 22287944 DOI: 10.3389/Fnsys.2011.00092  0.756
2010 Blesa J, Juri C, Collantes M, Peñuelas I, Prieto E, Iglesias E, Martí-Climent J, Arbizu J, Zubieta JL, Rodríguez-Oroz MC, García-García D, Richter JA, Cavada C, Obeso JA. Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study. Neurobiology of Disease. 38: 456-63. PMID 20304066 DOI: 10.1016/J.Nbd.2010.03.006  0.715
2010 Bezard E, Porras G, Blesa J, Obeso JA. Chapter 37 - Compensatory Mechanisms in Experimental and Human Parkinsonism: Potential for New Therapies Handbook of Behavioral Neuroscience. 20: 641-652. DOI: 10.1016/B978-0-12-374767-9.00037-8  0.616
2009 Collantes M, Prieto E, Peñuelas I, Blesa J, Juri C, Martí-Climent JM, Quincoces G, Arbizu J, Riverol M, Zubieta JL, Rodriguez-Oroz MC, Luquin MR, Richter JA, Obeso JA. New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification. Neuroimage. 47: 533-9. PMID 19422919 DOI: 10.1016/J.Neuroimage.2009.04.078  0.536
2008 Obeso JA, Marin C, Rodriguez-Oroz C, Blesa J, Benitez-Temiño B, Mena-Segovia J, Rodríguez M, Olanow CW. The basal ganglia in Parkinson's disease: current concepts and unexplained observations. Annals of Neurology. 64: S30-46. PMID 19127584 DOI: 10.1002/Ana.21481  0.656
2008 Collantes M, Peñuelas I, Alvarez-Erviti L, Blesa J, Martí-Climent JM, Quincoces G, Delgado M, Ecay M, Martínez A, Arbizu J, Rodríguez-Oroz MC, Obeso J, Richter JA. [Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease]. Revista Espaã±Ola De Medicina Nuclear. 27: 103-11. PMID 18367048 DOI: 10.1157/13117191  0.582
2008 Collantes M, Peñuelas I, Álvarez-Erviti L, Blesa J, Martí-Climent JM, Quincoces G, Delgado M, Ecay M, Martínez A, Arbizu J, Rodríguez-Oroz MC, Obeso J, Richter JÁ. Use of 11C-(+)-α-dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease Revista Espanola De Medicina Nuclear. 27: 103-111. DOI: 10.1016/S1578-200X(08)70033-0  0.583
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