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Jose Obeso, M.D., Ph.D. - Publications

Affiliations: 
Neurociencias CIMA, Universidad de Navarra, Pamplona, Navarra, Spain 
 Neurology Universidad CEU San Pablo (Spain) 
Area:
Parkinson's Disease
Website:
http://gadeaciencia.org/teams/obeso-jose-a-2/
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251 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Del Rey NL, Hernández-Pinedo N, Carrillo M, Del Cerro M, Esteban-García N, Trigo-Damas I, Monje MHG, Lanciego JL, Cavada C, Obeso JA, Blesa J. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model. Npj Parkinson's Disease. 10: 165. PMID 39223183 DOI: 10.1038/s41531-024-00777-0  0.538
2024 Magrinelli F, Tesson C, Angelova PR, Salazar-Villacorta A, Rodriguez JA, Scardamaglia A, Chung BH, Jaconelli M, Vona B, Esteras N, Kwong AK, Courtin T, Maroofian R, Alavi S, Nirujogi R, ... ... Obeso JA, et al. variants cause a phenotypic spectrum from early-onset Parkinson's disease to perinatal lethality by disrupting mitochondrial pathways. Medrxiv : the Preprint Server For Health Sciences. PMID 39148840 DOI: 10.1101/2024.06.19.24308302  0.391
2024 Matarazzo M, Obeso JA. Alpha synuclein PET imaging, a step closer to in vivo neuropathology in Parkinson's disease and related disorders. Neuron. 112: 2457-2458. PMID 39116836 DOI: 10.1016/j.neuron.2024.07.001  0.353
2024 Obeso I, Loayza FR, González-Redondo R, Villagra F, Luis E, Jahanshahi M, Obeso JA, Pastor MA. The causal role of the subthalamic nucleus in the inhibitory network. Annals of the New York Academy of Sciences. PMID 39116019 DOI: 10.1111/nyas.15193  0.509
2024 Balzano T, Del Rey NL, Esteban-García N, Reinares-Sebastián A, Pineda-Pardo JA, Trigo-Damas I, Obeso JA, Blesa J. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. Npj Parkinson's Disease. 10: 118. PMID 38886348 DOI: 10.1038/s41531-024-00735-w  0.607
2024 Nambu A, Chiken S, Sano H, Hatanaka N, Obeso JA. [Dynamic activity model of movement disorders: a unified view to understand their pathophysiology]. Rinsho Shinkeigaku = Clinical Neurology. PMID 38811203 DOI: 10.5692/clinicalneurol.cn-001957  0.361
2024 Gasca-Salas C, Pineda-Pardo JA, Del Álamo M, Jiménez T, Trompeta C, Toltsis G, Garcia-Cañamaque L, Fernández-Rodríguez B, Matarazzo M, Plaza de Las Heras I, Natera-Villalba E, Martínez-Fernández R, Duque A, Ruiz de Aguiar S, Blesa J, ... ... Obeso JA, et al. Nigrostriatal blood-brain barrier opening in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 38760152 DOI: 10.1136/jnnp-2023-332967  0.61
2024 Martínez-Fernández R, Natera-Villalba E, Rodríguez-Rojas R, Del Álamo M, Pineda-Pardo JA, Obeso I, Guida P, Jiménez-Castellanos T, Pérez-Bueno D, Duque A, Mañez-Miró JU, Gasca-Salas C, Matarazzo M, Alonso-Frech F, Obeso JA. Staged Bilateral MRI-Guided Focused Ultrasound Subthalamotomy for Parkinson Disease. Jama Neurology. PMID 38739377 DOI: 10.1001/jamaneurol.2024.1220  0.382
2024 Olanow CW, McIntyre D, Matarazzo M, Leinonen M, McGarry A, Kamp C, Kennedy J, Torti M, Kruger R, Obeso JA, Stocchi F, Heller E, Kieburtz K. Continuous Levodopa Delivery with an Intraoral Micropump System: An Open-Label Pharmacokinetics and Clinical Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 38698639 DOI: 10.1002/mds.29824  0.401
2024 Mendonça MD, da Silva JA, Hernandez LF, Castela I, Obeso J, Costa RM. Dopamine neuron activity encodes the length of upcoming contralateral movement sequences. Current Biology : Cb. PMID 38377999 DOI: 10.1016/j.cub.2024.01.067  0.706
2024 Ammann C, Oliviero A, Obeso JA, Foffani G. Motor Cortex Disinhibition Is Not Associated with Freezing of Gait in Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 38178799 DOI: 10.1002/mds.29709  0.405
2023 Teil M, Dovero S, Bourdenx M, Arotcarena ML, Darricau M, Porras G, Thiolat ML, Trigo-Damas I, Perier C, Estrada C, Garcia-Carrillo N, Herrero MT, Vila M, Obeso JA, Bezard E, et al. Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain. Npj Parkinson's Disease. 9: 135. PMID 37726343 DOI: 10.1038/s41531-023-00579-w  0.392
2023 Martínez Fernández R, Natera Villalba E, Rodriguez-Rojas R, Del Álamo M, Pineda-Pardo JA, Obeso I, Mata-Marín D, Guida P, Jimenez-Castellanos T, Pérez-Bueno D, Duque A, Máñez Miró JU, Gasca-Salas C, Matarazzo M, Obeso JA. Unilateral focused ultrasound subthalamotomy in early Parkinson's disease: a pilot study. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 37673642 DOI: 10.1136/jnnp-2023-331211  0.426
2023 Blesa J, Pineda-Pardo JA, Inoue KI, Gasca-Salas C, Balzano T, Del Rey NL, Reinares-Sebastián A, Esteban-García N, Rodríguez-Rojas R, Márquez R, Ciorraga M, Del Álamo M, García-Cañamaque L, Ruiz de Aguiar S, Rachmilevitch I, ... ... Obeso JA, et al. BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging. Science Advances. 9: eadf4888. PMID 37075119 DOI: 10.1126/sciadv.adf4888  0.546
2023 Martinez-Fernandez R, Natera-Villalba E, Máñez Miró JU, Rodriguez-Rojas R, Marta Del Álamo M, Pineda-Pardo JÁ, Ammann C, Obeso I, Mata-Marín D, Hernández-Fernández F, Gasca-Salas C, Matarazzo M, Alonso-Frech F, Obeso JA. Prospective Long-term Follow-up of Focused Ultrasound Unilateral Subthalamotomy for Parkinson Disease. Neurology. PMID 36631272 DOI: 10.1212/WNL.0000000000206771  0.409
2022 Castela I, Casado-Polanco R, Rubio YV, da Silva JA, Marquez R, Pro B, Moratalla R, Redgrave P, Costa RM, Obeso J, Hernández LF. Selective activation of striatal indirect pathway suppresses levodopa induced-dyskinesias. Neurobiology of Disease. 105930. PMID 36414182 DOI: 10.1016/j.nbd.2022.105930  0.749
2022 Pineda-Pardo JA, Gasca-Salas C, Fernández-Rodríguez B, Rodríguez-Rojas R, Del Álamo M, Obeso I, Hernández-Fernández F, Trompeta C, Martínez-Fernández R, Matarazzo M, Mata-Marín D, Guida P, Duque A, Albillo D, Plaza de Las Heras I, ... ... Obeso JA, et al. Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35765711 DOI: 10.1002/mds.29134  0.632
2022 Lin SJ, Rodriguez-Rojas R, Baumeister TR, Lenglos C, Pineda-Pardo JA, Máñez-Miró JU, Del Alamo M, Martinez-Fernandez R, Obeso JA, Iturria-Medina Y. Neuroimaging signatures predicting motor improvement to focused ultrasound subthalamotomy in Parkinson's disease. Npj Parkinson's Disease. 8: 70. PMID 35665753 DOI: 10.1038/s41531-022-00332-9  0.316
2022 Dileone M, Ammann C, Catanzaro V, Pagge C, Piredda R, Monje MHG, Navalpotro-Gomez I, Bergareche A, Rodríguez-Oroz MC, Vela-Desojo L, Alonso-Frech F, Catalán MJ, Molina JA, López-Ariztegu N, Oliviero A, ... Obeso JA, et al. Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial. Brain Stimulation. 15: 857-860. PMID 35609815 DOI: 10.1016/j.brs.2022.05.012  0.332
2022 Pineda-Pardo JA, Sánchez-Ferro Á, Monje MHG, Pavese N, Obeso JA. Onset pattern of nigrostriatal denervation in early Parkinson's disease. Brain : a Journal of Neurology. 145: 1018-1028. PMID 35349639 DOI: 10.1093/brain/awab378  0.462
2022 Teil M, Dovero S, Bourdenx M, Arotcarena ML, Camus S, Porras G, Thiolat ML, Trigo-Damas I, Perier C, Estrada C, Garcia-Carrillo N, Morari M, Meissner WG, Herrero MT, Vila M, ... Obeso JA, et al. Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology. Brain : a Journal of Neurology. PMID 35285474 DOI: 10.1093/brain/awab374  0.304
2022 Del Rey NL, Trigo-Damas I, Obeso JA, Cavada C, Blesa J. Neuron types in the primate striatum: Stereological analysis of projection neurons and interneurons in control and parkinsonian monkeys. Neuropathology and Applied Neurobiology. e12812. PMID 35274336 DOI: 10.1111/nan.12812  0.521
2022 Molinet-Dronda F, Blesa J, Del Rey NL, Juri C, Collantes M, Pineda-Pardo JA, Trigo-Damas I, Iglesias E, Hernández LF, Rodríguez-Rojas R, Gago B, Ecay M, Prieto E, García-Cabezas MÁ, Cavada C, ... ... Obeso JA, et al. Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism. Neurobiology of Disease. 167: 105669. PMID 35219857 DOI: 10.1016/j.nbd.2022.105669  0.807
2022 Loayza FR, Obeso I, Redondo RG, Villagra F, Luis E, Obeso JA, Jahanshahi M, Pastor MA. The motor inhibitory network in patients with asymmetrical Parkinson's disease: An fMRI study. Brain Imaging and Behavior. PMID 35020124 DOI: 10.1007/s11682-021-00587-5  0.555
2021 Blesa J, Foffani G, Dehay B, Bezard E, Obeso JA. Motor and non-motor circuit disturbances in early Parkinson disease: which happens first? Nature Reviews. Neuroscience. PMID 34907352 DOI: 10.1038/s41583-021-00542-9  0.674
2021 Rodriguez-Rojas R, Pineda-Pardo JA, Mañez-Miro J, Sanchez-Turel A, Martinez-Fernandez R, Del Alamo M, DeLong M, Obeso JA. Functional Topography of the Human Subthalamic Nucleus: Relevance for Subthalamotomy in Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34859498 DOI: 10.1002/mds.28862  0.445
2021 Monje MHG, Sánchez-Ferro Á, Pineda-Pardo JÁ, Vela-Desojo L, Alonso-Frech F, Obeso JÁ. Reply to: Motor Features in a Peruvian Cohort of Parkinson's Disease Patients. Movement Disorders : Official Journal of the Movement Disorder Society. 36: 1994-1995. PMID 34409687 DOI: 10.1002/mds.28690  0.393
2021 Máñez-Miró JU, Rodríguez-Rojas R, Del Álamo M, Martínez-Fernández R, Obeso JA. Present and future of subthalamotomy in the management of Parkinson´s disease: a systematic review. Expert Review of Neurotherapeutics. PMID 33788645 DOI: 10.1080/14737175.2021.1911649  0.442
2021 Monje MHG, Sánchez-Ferro Á, Pineda-Pardo JA, Vela-Desojo L, Alonso-Frech F, Obeso JA. Motor Onset Topography and Progression in Parkinson's Disease: the Upper Limb Is First. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33471950 DOI: 10.1002/mds.28462  0.485
2020 Martínez-Fernández R, Máñez-Miró JU, Rodríguez-Rojas R, Del Álamo M, Shah BB, Hernández-Fernández F, Pineda-Pardo JA, Monje MHG, Fernández-Rodríguez B, Sperling SA, Mata-Marín D, Guida P, Alonso-Frech F, Obeso I, Gasca-Salas C, ... ... Obeso JA, et al. Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson's Disease. The New England Journal of Medicine. 383: 2501-2513. PMID 33369354 DOI: 10.1056/NEJMoa2016311  0.35
2020 Ammann C, Dileone M, Pagge C, Catanzaro V, Mata-Marín D, Hernández-Fernández F, Monje MHG, Sánchez-Ferro Á, Fernández-Rodríguez B, Gasca-Salas C, Máñez-Miró JU, Martínez-Fernández R, Vela-Desojo L, Alonso-Frech F, Oliviero A, ... Obeso JA, et al. Cortical disinhibition in Parkinson's disease. Brain : a Journal of Neurology. PMID 33141146 DOI: 10.1093/brain/awaa274  0.447
2020 Olanow CW, Calabresi P, Obeso JA. Continuous Dopaminergic Stimulation as a Treatment for Parkinson's Disease: Current Status and Future Opportunities. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32816321 DOI: 10.1002/mds.28215  0.471
2020 Arotcarena ML, Dovero S, Prigent A, Bourdenx M, Camus S, Porras G, Thiolat ML, Tasselli M, Aubert P, Kruse N, Mollenhauer B, Damas IT, Estrada C, Garcia-Carrillo N, Vaikath NN, ... ... Obeso JA, et al. Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates. Brain : a Journal of Neurology. PMID 32380543 DOI: 10.1093/Brain/Awaa096  0.329
2019 Monje MHG, Blesa J, García-Cabezas MÁ, Obeso JA, Cavada C. Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31800134 DOI: 10.1002/Mds.27921  0.652
2019 Meles SK, Renken RJ, Pagani M, Teune LK, Arnaldi D, Morbelli S, Nobili F, van Laar T, Obeso JA, Rodríguez-Oroz MC, Leenders KL. Abnormal pattern of brain glucose metabolism in Parkinson's disease: replication in three European cohorts. European Journal of Nuclear Medicine and Molecular Imaging. PMID 31768600 DOI: 10.1007/S00259-019-04570-7  0.378
2019 Jiménez-Sánchez L, Blesa J, Del Rey NL, Monje MH, Obeso JA, Cavada C. Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease. Neuropharmacology. 107806. PMID 31589886 DOI: 10.1016/J.Neuropharm.2019.107806  0.633
2019 Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31483900 DOI: 10.1002/Mds.27823  0.448
2019 Foffani G, Trigo-Damas I, Pineda-Pardo JA, Blesa J, Rodríguez-Rojas R, Martínez-Fernández R, Obeso JA. Focused ultrasound in Parkinson's disease: A twofold path toward disease modification. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31412430 DOI: 10.1002/Mds.27805  0.651
2019 Matarazzo M, Arroyo-Gallego T, Montero P, Puertas-Martín V, Butterworth I, Mendoza CS, Ledesma-Carbayo MJ, Catalán MJ, Molina JA, Bermejo-Pareja F, Martínez-Castrillo JC, López-Manzanares L, Alonso-Cánovas A, Rodríguez JH, Obeso I, ... ... Obeso JA, et al. Remote Monitoring of Treatment Response in Parkinson's Disease: The Habit of Typing on a Computer. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31211469 DOI: 10.1002/Mds.27772  0.378
2019 Monje MHG, Foffani G, Obeso J, Sánchez-Ferro Á. New Sensor and Wearable Technologies to Aid in the Diagnosis and Treatment Monitoring of Parkinson's Disease. Annual Review of Biomedical Engineering. 21: 111-143. PMID 31167102 DOI: 10.1146/Annurev-Bioeng-062117-121036  0.479
2019 Hernandez LF, Obeso I, Costa RM, Redgrave P, Obeso JA. Dopaminergic Vulnerability in Parkinson Disease: The Cost of Humans' Habitual Performance. Trends in Neurosciences. PMID 31053241 DOI: 10.1016/J.Tins.2019.03.007  0.766
2019 Manzanera OM, Meles SK, Leenders KL, Renken RJ, Pagani M, Arnaldi D, Nobili F, Obeso J, Oroz MR, Morbelli S, Maurits NM. Scaled Subprofile Modeling and Convolutional Neural Networks for the Identification of Parkinson's Disease in 3D Nuclear Imaging Data. International Journal of Neural Systems. 1950010. PMID 31046514 DOI: 10.1142/S0129065719500102  0.427
2019 Obeso JA. Movement disorders journal conference 2018: Neuronal vulnerability in Parkinson's disease Movement Disorders. 34: 1405-1405. DOI: 10.1002/mds.27890  0.309
2018 Foffani G, Obeso JA. A Cortical Pathogenic Theory of Parkinson's Disease. Neuron. 99: 1116-1128. PMID 30236282 DOI: 10.1016/J.Neuron.2018.07.028  0.45
2018 Berg D, Adler CH, Bloem BR, Chan P, Gasser T, Goetz CG, Halliday G, Lang AE, Lewis S, Li Y, Liepelt-Scarfone I, Litvan I, Marek K, Maetzler C, Mi T, ... Obeso J, et al. Movement disorder society criteria for clinically established early Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30145841 DOI: 10.1002/Mds.27431  0.488
2018 Diez-Fairen M, Benitez BA, Ortega-Cubero S, Lorenzo-Betancor O, Cruchaga C, Lorenzo E, Samaranch L, Carcel M, Obeso JA, Rodriguez-Oroz MC, Aguilar M, Coria F, Pastor MA, Pastor P. Pooled-DNA target sequencing of Parkinson genes reveals novel phenotypic associations in Spanish population. Neurobiology of Aging. PMID 29887346 DOI: 10.1016/J.Neurobiolaging.2018.05.008  0.319
2018 Humphries MD, Obeso JA, Dreyer JK. Insights into Parkinson's disease from computational models of the basal ganglia. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29666208 DOI: 10.1136/Jnnp-2017-315922  0.307
2018 Antonini A, Obeso JA. DBS for Parkinson's disease with behavioural disturbances. The Lancet. Neurology. 17: 195-197. PMID 29452675 DOI: 10.1016/S1474-4422(18)30044-9  0.331
2017 Rodriguez-Rojas R, Carballo-Barreda M, Alvarez L, Guridi J, Pavon N, Garcia-Maeso I, Macías R, Rodriguez-Oroz MC, Obeso JA. Subthalamotomy for Parkinson's disease: clinical outcome and topography of lesions. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29222224 DOI: 10.1136/jnnp-2017-316241  0.413
2017 Picconi B, Hernández LF, Obeso JA, Calabresi P. Motor complications in Parkinson's disease: Striatal molecular and electrophysiological mechanisms of dyskinesias. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29219207 DOI: 10.1002/Mds.27261  0.745
2017 Martínez-Fernández R, Rodríguez-Rojas R, Del Álamo M, Hernández-Fernández F, Pineda-Pardo JA, Dileone M, Alonso-Frech F, Foffani G, Obeso I, Gasca-Salas C, de Luis-Pastor E, Vela L, Obeso JA. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study. The Lancet. Neurology. PMID 29203153 DOI: 10.1016/S1474-4422(17)30403-9  0.326
2017 Surmeier DJ, Obeso JA, Halliday GM. Parkinson's Disease Is Not Simply a Prion Disorder. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 9799-9807. PMID 29021297 DOI: 10.1523/JNEUROSCI.1787-16.2017  0.408
2017 Blesa J, Trigo-Damas I, Dileone M, Del Rey NL, Hernandez LF, Obeso JA. Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification. Experimental Neurology. PMID 28987461 DOI: 10.1016/J.Expneurol.2017.10.002  0.82
2017 Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, et al. Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy. Movement Disorders : Official Journal of the Movement Disorder Society. 32: 1264-1310. PMID 28887905 DOI: 10.1002/Mds.27115  0.589
2017 Quiroga-Varela A, Aguilar E, Iglesias E, Obeso JA, Marin C. Short- and long-term effects induced by repeated 6-OHDA intraventricular administration: A new progressive and bilateral rodent model of Parkinson's disease. Neuroscience. 361: 144-156. PMID 28823819 DOI: 10.1016/J.Neuroscience.2017.08.017  0.695
2017 Obeso JA, Trenkwalder C. What would Dr. James Parkinson think today? The 21st Annual Congress of the International Parkinson's disease and movement disorders society. Movement Disorders : Official Journal of the Movement Disorder Society. 32: 951-954. PMID 28712120 DOI: 10.1002/mds.27108  0.357
2017 Obeso I, Casabona E, Rodríguez-Rojas R, Bringas ML, Macías R, Pavón N, Obeso JA, Jahanshahi M. Unilateral subthalamotomy in Parkinson's disease: Cognitive, psychiatric and neuroimaging changes. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 94: 39-48. PMID 28711816 DOI: 10.1016/J.Cortex.2017.06.006  0.589
2017 Gasca-Salas C, García-Lorenzo D, Garcia-Garcia D, Clavero P, Obeso JA, Lehericy S, Rodríguez-Oroz MC. Parkinson's disease with mild cognitive impairment: severe cortical thinning antedates dementia. Brain Imaging and Behavior. PMID 28710667 DOI: 10.1007/s11682-017-9751-6  0.352
2017 Dileone M, Carrasco-López MC, Segundo-Rodriguez JC, Mordillo-Mateos L, López-Ariztegui N, Alonso-Frech F, Catalan-Alonso MJ, Obeso JA, Oliviero A, Foffani G. Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson's disease. Scientific Reports. 7: 4329. PMID 28659614 DOI: 10.1038/s41598-017-04254-y  0.323
2017 Pifl C, Reither H, Del Rey NL, Cavada C, Obeso JA, Blesa J. Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys. Frontiers in Neuroanatomy. 11: 46. PMID 28611598 DOI: 10.3389/Fnana.2017.00046  0.678
2017 Blesa J, Trigo-Damas I, Del Rey NL, Obeso JA. The use of nonhuman primate models to understand processes in Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 28357564 DOI: 10.1007/S00702-017-1715-X  0.676
2017 F Hernández L, Castela I, Ruiz-DeDiego I, Obeso JA, Moratalla R. Striatal activation by optogenetics induces dyskinesias in the 6-hydroxydopamine rat model of Parkinson disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28256089 DOI: 10.1002/Mds.26947  0.356
2017 Voon V, Napier TC, Frank MJ, Sgambato-Faure V, Grace AA, Rodriguez-Oroz M, Obeso J, Bezard E, Fernagut PO. Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update. The Lancet. Neurology. 16: 238-250. PMID 28229895 DOI: 10.1016/S1474-4422(17)30004-2  0.392
2017 Hariz M, Obeso JA. What Would Dr. James Parkinson Think Today? I. The Role of Functional Neurosurgery for Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. 32: 2-4. PMID 28124429 DOI: 10.1002/mds.26911  0.375
2017 Dileone M, Mateos LM, Carrasco-Lopez M, Segundo-Rodriguez J, López-Aristegu N, Alonso-Frech F, Catalan-Alonso M, Obeso J, Oliviero A, Foffani G. P037 Transcranial static magnetic field stimulation-induced modulation of motor cortex excitability in Parkinson’s disease Clinical Neurophysiology. 128: e26. DOI: 10.1016/J.Clinph.2016.10.165  0.424
2016 Giancardo L, Sánchez-Ferro A, Arroyo-Gallego T, Butterworth I, Mendoza CS, Montero P, Matarazzo M, Obeso JA, Gray ML, Estépar RS. Computer keyboard interaction as an indicator of early Parkinson's disease. Scientific Reports. 6: 34468. PMID 27703257 DOI: 10.1038/Srep34468  0.464
2016 Singh A, Mewes K, Gross RE, DeLong MR, Obeso JA, Papa SM. Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 113: 9629-34. PMID 27503874 DOI: 10.1073/Pnas.1606792113  0.441
2016 Calabresi P, Pisani A, Rothwell J, Ghiglieri V, Obeso JA, Picconi B. Hyperkinetic disorders and loss of synaptic downscaling. Nature Neuroscience. 19: 868-75. PMID 27351172 DOI: 10.1038/nn.4306  0.43
2016 Blesa J, Trigo-Damas I, Obeso JA. Parkinson's disease and thalamus: facts and fancy. The Lancet. Neurology. 15: e2. PMID 27302241 DOI: 10.1016/S1474-4422(16)30048-5  0.613
2015 Hernández LF, Redgrave P, Obeso JA. Corrigendum: Habitual Behavior and Dopamine Cell Vulnerability in Parkinson Disease. Frontiers in Neuroanatomy. 9: 146. PMID 26635540 DOI: 10.3389/Fnana.2015.00146  0.693
2015 Jahanshahi M, Obeso I, Rothwell JC, Obeso JA. A fronto-striato-subthalamic-pallidal network for goal-directed and habitual inhibition. Nature Reviews. Neuroscience. PMID 26530468 DOI: 10.1038/Nrn4038  0.635
2015 Berg D, Postuma RB, Adler CH, Bloem BR, Chan P, Dubois B, Gasser T, Goetz CG, Halliday G, Joseph L, Lang AE, Liepelt-Scarfone I, Litvan I, Marek K, Obeso J, et al. MDS research criteria for prodromal Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 1600-11. PMID 26474317 DOI: 10.1002/Mds.26431  0.482
2015 Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, et al. MDS clinical diagnostic criteria for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 1591-601. PMID 26474316 DOI: 10.1002/Mds.26424  0.485
2015 Blesa J, Lanciego JL, Obeso JA. Editorial: Parkinson's disease: cell vulnerability and disease progression. Frontiers in Neuroanatomy. 9: 125. PMID 26441555 DOI: 10.3389/Fnana.2015.00125  0.653
2015 Hernández LF, Redgrave P, Obeso JA. Habitual behavior and dopamine cell vulnerability in Parkinson disease. Frontiers in Neuroanatomy. 9: 99. PMID 26300740 DOI: 10.3389/Fnana.2015.00099  0.71
2015 Mellone M, Stanic J, Hernandez LF, Iglesias E, Zianni E, Longhi A, Prigent A, Picconi B, Calabresi P, Hirsch EC, Obeso JA, Di Luca M, Gardoni F. NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients. Frontiers in Cellular Neuroscience. 9: 245. PMID 26217176 DOI: 10.3389/Fncel.2015.00245  0.746
2015 Molinet-Dronda F, Gago B, Quiroga-Varela A, Juri C, Collantes M, Delgado M, Prieto E, Ecay M, Iglesias E, Marín C, Peñuelas I, Obeso JA. Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study. Neurobiology of Disease. 77: 165-72. PMID 25681534 DOI: 10.1016/J.Nbd.2015.01.007  0.562
2015 Guridi J, Obeso JA. Letter to the editor: Parkinson's disease and early subthalamotomy. Journal of Neurosurgery. 122: 980-1. PMID 25679280 DOI: 10.3171/2014.8.JNS141799  0.339
2015 Rothwell JC, Obeso JA. Can levodopa-induced dyskinesias go beyond the motor circuit? Brain : a Journal of Neurology. 138: 242-4. PMID 25627235 DOI: 10.1093/brain/awu365  0.487
2015 Schneider SA, Obeso JA. Clinical and pathological features of Parkinson's disease. Current Topics in Behavioral Neurosciences. 22: 205-20. PMID 24850081 DOI: 10.1007/7854_2014_317  0.43
2015 Mellone M, Stanic J, Hernandez LF, Iglesias E, Zianni E, Longhi A, Prigent A, Picconi B, Calabresi P, Hirsch EC, Obeso JA, Luca MD, Gardoni F. NMDA receptor gluN2A/gluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: From experimental models to patients Frontiers in Cellular Neuroscience. 9. DOI: 10.3389/fncel.2015.00245  0.686
2014 Obeso JA, Rodriguez-Oroz MC, Stamelou M, Bhatia KP, Burn DJ. The expanding universe of disorders of the basal ganglia. Lancet. 384: 523-31. PMID 24954674 DOI: 10.1016/S0140-6736(13)62418-6  0.349
2014 Pifl C, Rajput A, Reither H, Blesa J, Cavada C, Obeso JA, Rajput AH, Hornykiewicz O. Is Parkinson's disease a vesicular dopamine storage disorder? Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8210-8. PMID 24920625 DOI: 10.1523/Jneurosci.5456-13.2014  0.657
2014 Obeso I, Wilkinson L, Casabona E, Speekenbrink M, Luisa Bringas M, Álvarez M, Álvarez L, Pavón N, Rodríguez-Oroz MC, Macías R, Obeso JA, Jahanshahi M. The subthalamic nucleus and inhibitory control: impact of subthalamotomy in Parkinson's disease. Brain : a Journal of Neurology. 137: 1470-80. PMID 24657985 DOI: 10.1093/Brain/Awu058  0.534
2014 Berg D, Postuma RB, Bloem B, Chan P, Dubois B, Gasser T, Goetz CG, Halliday GM, Hardy J, Lang AE, Litvan I, Marek K, Obeso J, Oertel W, Olanow CW, et al. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 454-62. PMID 24619848 DOI: 10.1002/Mds.25844  0.495
2014 Toledo JB, López-Azcárate J, Garcia-Garcia D, Guridi J, Valencia M, Artieda J, Obeso J, Alegre M, Rodriguez-Oroz M. High beta activity in the subthalamic nucleus and freezing of gait in Parkinson's disease. Neurobiology of Disease. 64: 60-5. PMID 24361601 DOI: 10.1016/J.Nbd.2013.12.005  0.396
2014 Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez-Villalba A, Fernagut PO, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bezard E, Vila M. Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys. Annals of Neurology. 75: 351-62. PMID 24243558 DOI: 10.1002/Ana.24066  0.645
2014 Merello M, Damas IT, Obeso JA. Features and mechanisms of diphasic dyskinesia in Parkinson's disease Levodopa-Induced Dyskinesia in Parkinson's Disease. 135-146. DOI: 10.1007/978-1-4471-6503-3_8  0.315
2013 Ballaz S, Morales I, Rodríguez M, Obeso JA. Ascorbate prevents cell death from prolonged exposure to glutamate in an in vitro model of human dopaminergic neurons. Journal of Neuroscience Research. 91: 1609-17. PMID 23996657 DOI: 10.1002/jnr.23276  0.302
2013 Bézard E, Olanow CW, Obeso JA. Levodopa-induced dyskinesias in the absence of nigrostriatal degeneration. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1023-4. PMID 23787890 DOI: 10.1002/mds.25533  0.4
2013 Quiroga-Varela A, Walters JR, Brazhnik E, Marin C, Obeso JA. What basal ganglia changes underlie the parkinsonian state? The significance of neuronal oscillatory activity. Neurobiology of Disease. 58: 242-8. PMID 23727447 DOI: 10.1016/j.nbd.2013.05.010  0.365
2013 Berg D, Lang AE, Postuma RB, Maetzler W, Deuschl G, Gasser T, Siderowf A, Schapira AH, Oertel W, Obeso JA, Olanow CW, Poewe W, Stern M. Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities. The Lancet. Neurology. 12: 514-24. PMID 23582175 DOI: 10.1016/S1474-4422(13)70047-4  0.371
2013 Obeso I, Wilkinson L, Rodríguez-Oroz MC, Obeso JA, Jahanshahi M. Bilateral stimulation of the subthalamic nucleus has differential effects on reactive and proactive inhibition and conflict-induced slowing in Parkinson's disease. Experimental Brain Research. 226: 451-62. PMID 23525560 DOI: 10.1007/S00221-013-3457-9  0.508
2013 Obeso JA, Guridi J, Nambu A, Crossman AR. Motor manifestations and basal ganglia output activity: the paradox continues. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 416-8. PMID 23494928 DOI: 10.1002/mds.25358  0.311
2013 Alvarez-Erviti L, Seow Y, Schapira AH, Rodriguez-Oroz MC, Obeso JA, Cooper JM. Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease. Cell Death & Disease. 4: e545. PMID 23492776 DOI: 10.1038/cddis.2013.73  0.316
2013 Ortega-Cubero S, Clavero P, Irurzun C, Gonzalez-Redondo R, Guridi J, Obeso JA, Rodriguez-Oroz MC. Effect of deep brain stimulation of the subthalamic nucleus on non-motor fluctuations in Parkinson's disease: two-years' follow-up. Parkinsonism & Related Disorders. 19: 543-7. PMID 23453890 DOI: 10.1016/j.parkreldis.2013.02.001  0.344
2013 Olanow CW, Obeso JA, Stocchi F. The vatican meeting on neuroprotection for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1-2. PMID 23390093 DOI: 10.1002/mds.25356  0.347
2013 Pifl C, Hornykiewicz O, Blesa J, Adánez R, Cavada C, Obeso JA. Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of parkinsonism. Journal of Neurochemistry. 125: 657-62. PMID 23331162 DOI: 10.1111/Jnc.12162  0.788
2013 Alegre M, Lopez-Azcarate J, Obeso I, Wilkinson L, Rodriguez-Oroz MC, Valencia M, Garcia-Garcia D, Guridi J, Artieda J, Jahanshahi M, Obeso JA. The subthalamic nucleus is involved in successful inhibition in the stop-signal task: a local field potential study in Parkinson's disease. Experimental Neurology. 239: 1-12. PMID 22975442 DOI: 10.1016/J.Expneurol.2012.08.027  0.535
2012 Guridi J, González-Redondo R, Obeso JA. Clinical features, pathophysiology, and treatment of levodopa-induced dyskinesias in Parkinson's disease. Parkinson's Disease. 2012: 943159. PMID 23125942 DOI: 10.1155/2012/943159  0.399
2012 Lanciego JL, Luquin N, Obeso JA. Functional neuroanatomy of the basal ganglia. Cold Spring Harbor Perspectives in Medicine. 2: a009621. PMID 23071379 DOI: 10.1101/cshperspect.a009621  0.324
2012 Alegre M, López-Azcárate J, Alonso-Frech F, Rodríguez-Oroz MC, Valencia M, Guridi J, Artieda J, Obeso JA. Subthalamic activity during diphasic dyskinesias in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 1178-81. PMID 22744752 DOI: 10.1002/mds.25090  0.35
2012 Blesa J, Pifl C, Sánchez-González MA, Juri C, García-Cabezas MA, Adánez R, Iglesias E, Collantes M, Peñuelas I, Sánchez-Hernández JJ, Rodríguez-Oroz MC, Avendaño C, Hornykiewicz O, Cavada C, Obeso JA. The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: a PET, histological and biochemical study. Neurobiology of Disease. 48: 79-91. PMID 22677034 DOI: 10.1016/J.Nbd.2012.05.018  0.798
2012 Olanow CW, Obeso JA. The significance of defining preclinical or prodromal Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 666-9. PMID 22508285 DOI: 10.1002/mds.25019  0.394
2012 Aron AR, Obeso J. Is executive control used to compensate for involuntary movements in levodopa-induced dyskinesia? Movement Disorders : Official Journal of the Movement Disorder Society. 27: 339-40. PMID 22411844 DOI: 10.1002/Mds.24936  0.342
2011 Blesa J, Juri C, García-Cabezas MÁ, Adánez R, Sánchez-González MÁ, Cavada C, Obeso JA. Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: a possible compensatory mechanism in Parkinson's disease. Frontiers in Systems Neuroscience. 5: 92. PMID 22287944 DOI: 10.3389/Fnsys.2011.00092  0.806
2011 Olanow CW, Obeso JA. Levodopa toxicity and Parkinson disease: still a need for equipoise. Neurology. 77: 1416-7. PMID 21917774 DOI: 10.1212/WNL.0b013e318232ac0a  0.347
2011 Cerquetti D, Obeso JA, Merello M. Neuronal discharge patterns in the globus pallidus pars interna in a patient with Parkinson's disease and hemiballismus secondary to subthalamotomy. Experimental Brain Research. 213: 447-55. PMID 21786135 DOI: 10.1007/s00221-011-2794-9  0.394
2011 Obeso I, Wilkinson L, Casabona E, Bringas ML, Álvarez M, Álvarez L, Pavón N, Rodríguez-Oroz MC, Macías R, Obeso JA, Jahanshahi M. Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson's disease. Experimental Brain Research. 212: 371-84. PMID 21643718 DOI: 10.1007/S00221-011-2736-6  0.599
2011 Wichmann T, DeLong MR, Guridi J, Obeso JA. Milestones in research on the pathophysiology of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 1032-41. PMID 21626548 DOI: 10.1002/mds.23695  0.482
2011 Meissner WG, Frasier M, Gasser T, Goetz CG, Lozano A, Piccini P, Obeso JA, Rascol O, Schapira A, Voon V, Weiner DM, Tison F, Bezard E. Priorities in Parkinson's disease research. Nature Reviews. Drug Discovery. 10: 377-93. PMID 21532567 DOI: 10.1038/Nrd3430  0.362
2011 Rodriguez-Oroz MC, López-Azcárate J, Garcia-Garcia D, Alegre M, Toledo J, Valencia M, Guridi J, Artieda J, Obeso JA. Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson's disease. Brain : a Journal of Neurology. 134: 36-49. PMID 21059746 DOI: 10.1093/brain/awq301  0.389
2011 Alegre M, Obeso I, Lopez-Azcarate J, Rodriguez-Oroz MC, Wilkinson L, Guridi J, Valencia M, Artieda J, Jahanshahi M, Obeso J. P7.9 Subthalamic activity during a motor inhibition task Clinical Neurophysiology. 122: S91. DOI: 10.1016/S1388-2457(11)60319-2  0.496
2010 Marin C, Obeso JA. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of L-dopa treatment. International Review of Neurobiology. 95: 191-205. PMID 21095463 DOI: 10.1016/B978-0-12-381326-8.00008-9  0.331
2010 Redgrave P, Rodriguez M, Smith Y, Rodriguez-Oroz MC, Lehericy S, Bergman H, Agid Y, DeLong MR, Obeso JA. Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease. Nature Reviews. Neuroscience. 11: 760-72. PMID 20944662 DOI: 10.1038/Nrn2915  0.388
2010 Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, Caballero C, Ferrer I, Obeso JA, Schapira AH. Chaperone-mediated autophagy markers in Parkinson disease brains. Archives of Neurology. 67: 1464-72. PMID 20697033 DOI: 10.1001/archneurol.2010.198  0.361
2010 Bickel S, Alvarez L, Macias R, Pavon N, Leon M, Fernandez C, Houghton DJ, Salazar S, Rodríguez-Oroz MC, Juncos J, Guridi J, Delong M, Obeso JA, Litvan I. Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson's disease. Parkinsonism & Related Disorders. 16: 535-9. PMID 20650671 DOI: 10.1016/J.Parkreldis.2010.06.008  0.343
2010 Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G. Missing pieces in the Parkinson's disease puzzle. Nature Medicine. 16: 653-61. PMID 20495568 DOI: 10.1038/Nm.2165  0.375
2010 López-Azcárate J, Tainta M, Rodríguez-Oroz MC, Valencia M, González R, Guridi J, Iriarte J, Obeso JA, Artieda J, Alegre M. Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6667-77. PMID 20463229 DOI: 10.1523/JNEUROSCI.5459-09.2010  0.316
2010 Stocchi F, Jenner P, Obeso JA. When do levodopa motor fluctuations first appear in Parkinson's disease? European Neurology. 63: 257-66. PMID 20332641 DOI: 10.1159/000300647  0.368
2010 Blesa J, Juri C, Collantes M, Peñuelas I, Prieto E, Iglesias E, Martí-Climent J, Arbizu J, Zubieta JL, Rodríguez-Oroz MC, García-García D, Richter JA, Cavada C, Obeso JA. Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study. Neurobiology of Disease. 38: 456-63. PMID 20304066 DOI: 10.1016/J.Nbd.2010.03.006  0.764
2010 Moro E, Lozano AM, Pollak P, Agid Y, Rehncrona S, Volkmann J, Kulisevsky J, Obeso JA, Albanese A, Hariz MI, Quinn NP, Speelman JD, Benabid AL, Fraix V, Mendes A, et al. Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 578-86. PMID 20213817 DOI: 10.1002/Mds.22735  0.386
2010 Alegre M, Rodríguez-Oroz MC, Valencia M, Pérez-Alcázar M, Guridi J, Iriarte J, Obeso JA, Artieda J. Changes in subthalamic activity during movement observation in Parkinson's disease: is the mirror system mirrored in the basal ganglia? Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 121: 414-25. PMID 20006544 DOI: 10.1016/j.clinph.2009.11.013  0.313
2010 Samaranch L, Lorenzo E, Pastor MA, Riverol M, Luquin MR, Rodríguez-Oroz MC, Obeso JA, Pastor P. Analysis of the GIGYF2 gene in familial and sporadic Parkinson disease in the Spanish population. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 17: 321-5. PMID 19845746 DOI: 10.1111/J.1468-1331.2009.02812.X  0.335
2010 Juri C, Rodriguez-Oroz M, Obeso JA. The pathophysiological basis of sensory disturbances in Parkinson's disease. Journal of the Neurological Sciences. 289: 60-5. PMID 19758602 DOI: 10.1016/j.jns.2009.08.018  0.436
2009 Olanow CW, Kordower JH, Lang AE, Obeso JA. Dopaminergic transplantation for Parkinson's disease: current status and future prospects. Annals of Neurology. 66: 591-6. PMID 19938101 DOI: 10.1002/Ana.21778  0.429
2009 Voon V, Fernagut PO, Wickens J, Baunez C, Rodriguez M, Pavon N, Juncos JL, Obeso JA, Bezard E. Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. The Lancet. Neurology. 8: 1140-9. PMID 19909912 DOI: 10.1016/S1474-4422(09)70287-X  0.401
2009 Rodriguez-Oroz MC, Jahanshahi M, Krack P, Litvan I, Macias R, Bezard E, Obeso JA. Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms. The Lancet. Neurology. 8: 1128-39. PMID 19909911 DOI: 10.1016/S1474-4422(09)70293-5  0.682
2009 Obeso JA, Jahanshahi M, Alvarez L, Macias R, Pedroso I, Wilkinson L, Pavon N, Day B, Pinto S, Rodríguez-Oroz MC, Tejeiro J, Artieda J, Talelli P, Swayne O, Rodríguez R, et al. What can man do without basal ganglia motor output? The effect of combined unilateral subthalamotomy and pallidotomy in a patient with Parkinson's disease. Experimental Neurology. 220: 283-92. PMID 19744484 DOI: 10.1016/J.Expneurol.2009.08.030  0.703
2009 Guridi J, García-Ruiz PJ, Rodríguez-Oroz MC, Valldeoriola F, Del Álamo M, Alberdi JA, Albisua J, Aparicio MA, Ayerbe J, Barcia JA, Bilbao G, Botella C, Catalán MJ, Castro A, De Fàbregues O, ... ... Obeso J, et al. Consensus statement on deep brain stimulation in Parkinson's disease | Documento de consenso sobre estimulación cerebral profunda en la enfermedad de Parkinson Revista De Neurologia. 49: 327-331. PMID 19728280  0.396
2009 Collantes M, Prieto E, Peñuelas I, Blesa J, Juri C, Martí-Climent JM, Quincoces G, Arbizu J, Riverol M, Zubieta JL, Rodriguez-Oroz MC, Luquin MR, Richter JA, Obeso JA. New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification. Neuroimage. 47: 533-9. PMID 19422919 DOI: 10.1016/J.Neuroimage.2009.04.078  0.537
2009 Volkmann J, Albanese A, Kulisevsky J, Tornqvist AL, Houeto JL, Pidoux B, Bonnet AM, Mendes A, Benabid AL, Fraix V, Van Blercom N, Xie J, Obeso J, Rodriguez-Oroz MC, Guridi J, et al. Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 1154-61. PMID 19412954 DOI: 10.1002/Mds.22496  0.318
2009 Vaamonde J, Flores JM, Weisser R, Ibañez R, Obeso JA. The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 762-5. PMID 19224589 DOI: 10.1002/mds.22234  0.438
2009 Alvarez L, Macias R, Pavón N, López G, Rodríguez-Oroz MC, Rodríguez R, Alvarez M, Pedroso I, Teijeiro J, Fernández R, Casabona E, Salazar S, Maragoto C, Carballo M, García I, ... ... Obeso JA, et al. Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months. Journal of Neurology, Neurosurgery, and Psychiatry. 80: 979-85. PMID 19204026 DOI: 10.1136/Jnnp.2008.154948  0.476
2009 Obeso JA, Schapira AH. Compensatory mechanisms in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 153-4. PMID 18649387 DOI: 10.1002/mds.22177  0.333
2009 Rico A, Barroso-Chinea P, Conte L, Roda E, Ómez-Bautista V, Ópez I, Obeso J, Lanciego J. P3.068 Basal ganglia hyperindirect pathway: direct projections from the subthalamic nucleus innervating the ventral motor thalamic nuclei in MPTP-treated primates Parkinsonism & Related Disorders. 15: S166. DOI: 10.1016/S1353-8020(09)70632-7  0.389
2008 Obeso JA, Marin C, Rodriguez-Oroz C, Blesa J, Benitez-Temiño B, Mena-Segovia J, Rodríguez M, Olanow CW. The basal ganglia in Parkinson's disease: current concepts and unexplained observations. Annals of Neurology. 64: S30-46. PMID 19127584 DOI: 10.1002/Ana.21481  0.658
2008 Obeso JA, Rodríguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M. Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 23: S548-59. PMID 18781672 DOI: 10.1002/mds.22062  0.38
2008 Olanow CW, Lees A, Obeso J. Levodopa therapy for Parkinson's disease: challenges and future prospects. Movement Disorders : Official Journal of the Movement Disorder Society. 23: S495-6. PMID 18781670 DOI: 10.1002/Mds.22048  0.408
2008 Marin C, Aguilar E, Mengod G, Cortés R, Rodríguez-Oroz MC, Obeso JA. Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes. Neurobiology of Disease. 32: 340-8. PMID 18722529 DOI: 10.1016/j.nbd.2008.07.019  0.332
2008 Rodriguez-Oroz MC, Rodriguez M, Leiva C, Rodriguez-Palmero M, Nieto J, Garcia-Garcia D, Luis Zubieta J, Cardiel C, Obeso JA. Neuronal activity of the red nucleus in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 908-11. PMID 18383534 DOI: 10.1002/mds.22000  0.406
2008 Collantes M, Peñuelas I, Alvarez-Erviti L, Blesa J, Martí-Climent JM, Quincoces G, Delgado M, Ecay M, Martínez A, Arbizu J, Rodríguez-Oroz MC, Obeso J, Richter JA. [Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease]. Revista Espaã±Ola De Medicina Nuclear. 27: 103-11. PMID 18367048 DOI: 10.1157/13117191  0.62
2008 Lanciego JL, Rodríguez-Oroz MC, Blesa FJ, Alvarez-Erviti L, Guridi J, Barroso-Chinea P, Smith Y, Obeso JA. Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 708-15. PMID 18175345 DOI: 10.1002/mds.21906  0.381
2008 Collantes M, Peñuelas I, Álvarez-Erviti L, Blesa J, Martí-Climent JM, Quincoces G, Delgado M, Ecay M, Martínez A, Arbizu J, Rodríguez-Oroz MC, Obeso J, Richter JÁ. Use of 11C-(+)-α-dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease Revista Espanola De Medicina Nuclear. 27: 103-111. DOI: 10.1016/S1578-200X(08)70033-0  0.621
2007 Obeso JA, Merello M, Rodríguez-Oroz MC, Marin C, Guridi J, Alvarez L. Levodopa-induced dyskinesias in Parkinson's disease. Handbook of Clinical Neurology. 84: 185-218. PMID 18808949 DOI: 10.1016/S0072-9752(07)84040-1  0.375
2007 Marin C, Aguilar E, Mengod G, Cortés R, Obeso JA. Concomitant short- and long-duration response to levodopa in the 6-OHDA-lesioned rat: a behavioural and molecular study. The European Journal of Neuroscience. 25: 259-69. PMID 17241287 DOI: 10.1111/j.1460-9568.2006.05265.x  0.305
2007 Rodríguez M, Morales I, González-Mora JL, Gómez I, Sabaté M, Dopico JG, Rodríguez-Oroz MC, Obeso JA. Different levodopa actions on the extracellular dopamine pools in the rat striatum. Synapse (New York, N.Y.). 61: 61-71. PMID 17117421 DOI: 10.1002/Syn.20342  0.33
2006 Schapira AH, Bezard E, Brotchie J, Calon F, Collingridge GL, Ferger B, Hengerer B, Hirsch E, Jenner P, Le Novère N, Obeso JA, Schwarzschild MA, Spampinato U, Davidai G. Novel pharmacological targets for the treatment of Parkinson's disease. Nature Reviews. Drug Discovery. 5: 845-54. PMID 17016425 DOI: 10.1038/Nrd2087  0.459
2006 Olanow CW, Obeso JA, Stocchi F. Drug insight: Continuous dopaminergic stimulation in the treatment of Parkinson's disease. Nature Clinical Practice. Neurology. 2: 382-92. PMID 16932589 DOI: 10.1038/ncpneuro0222  0.455
2006 Obeso JA, Rodriguez-Oroz MC, Javier Blesa F, Guridi J. The globus pallidus pars externa and Parkinson's disease. Ready for prime time? Experimental Neurology. 202: 1-7. PMID 16920102 DOI: 10.1016/j.expneurol.2006.07.004  0.332
2006 Olanow CW, Obeso JA, Stocchi F. Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications. The Lancet. Neurology. 5: 677-87. PMID 16857573 DOI: 10.1016/S1474-4422(06)70521-X  0.455
2006 Marin C, Aguilar E, Obeso JA. Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 646-53. PMID 16437585 DOI: 10.1002/mds.20780  0.338
2006 Marin C, Rodriguez-Oroz MC, Obeso JA. Motor complications in Parkinson's disease and the clinical significance of rotational behavior in the rat: have we wasted our time? Experimental Neurology. 197: 269-74. PMID 16375892 DOI: 10.1016/j.expneurol.2005.11.002  0.342
2005 Iravani MM, Costa S, Al-Bargouthy G, Jackson MJ, Zeng BY, Kuoppamäki M, Obeso JA, Jenner P. Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia. The European Journal of Neuroscience. 22: 1305-18. PMID 16190886 DOI: 10.1111/J.1460-9568.2005.04308.X  0.359
2005 Rodriguez-Oroz MC, Obeso JA, Lang AE, Houeto JL, Pollak P, Rehncrona S, Kulisevsky J, Albanese A, Volkmann J, Hariz MI, Quinn NP, Speelman JD, Guridi J, Zamarbide I, Gironell A, et al. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. Brain : a Journal of Neurology. 128: 2240-9. PMID 15975946 DOI: 10.1093/Brain/Awh571  0.337
2005 Castro A, Valldeoriola F, Linazasoro G, Rodriguez-Oroz MC, Stochi F, Marin C, Rodriguez M, Vaamonde J, Jenner P, Alvarez L, Pavon N, Macias R, Luquin MR, Hernandez B, Grandas F, ... ... Obeso JA, et al. [Optimization of use of levodopa in Parkinson's disease: role of levodopa-carbidopa-entacapone combination]. Neurologã­a (Barcelona, Spain). 20: 180-8. PMID 15891947  0.415
2005 Alvarez L, Macias R, Lopez G, Alvarez E, Pavon N, Rodriguez-Oroz MC, Juncos JL, Maragoto C, Guridi J, Litvan I, Tolosa ES, Koller W, Vitek J, DeLong MR, Obeso JA. Bilateral subthalamotomy in Parkinson's disease: initial and long-term response. Brain : a Journal of Neurology. 128: 570-83. PMID 15689366 DOI: 10.1093/Brain/Awh397  0.345
2004 Lanciego JL, Gonzalo N, Rodríguez-Oroz MC, Rodríguez M, Obeso JA. ["Neurorestorative" cell therapy in Parkinson's disease: an unresolved debate]. Anales Del Sistema Sanitario De Navarra. 27: 299-304. PMID 15644883 DOI: 10.4321/s1137-66272004000500002  0.336
2004 Olanow CW, Agid Y, Mizuno Y, Albanese A, Bonuccelli U, Bonucelli U, Damier P, De Yebenes J, Gershanik O, Guttman M, Grandas F, Hallett M, Hornykiewicz O, Jenner P, Katzenschlager R, ... ... Obeso JA, et al. Levodopa in the treatment of Parkinson's disease: current controversies. Movement Disorders : Official Journal of the Movement Disorder Society. 19: 997-1005. PMID 15372588 DOI: 10.1002/Mds.20243  0.597
2004 Lang AE, Obeso JA. Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease. Annals of Neurology. 55: 761-5. PMID 15174009 DOI: 10.1002/ana.20102  0.383
2004 Lang AE, Obeso JA. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. The Lancet. Neurology. 3: 309-16. PMID 15099546 DOI: 10.1016/S1474-4422(04)00740-9  0.436
2004 Obeso JA, Rodriguez-Oroz MC, Lanciego JL, Rodriguez Diaz M. How does Parkinson's disease begin? The role of compensatory mechanisms. Trends in Neurosciences. 27: 125-7; author reply . PMID 15036875 DOI: 10.1016/j.tins.2003.12.006  0.329
2004 Obeso JA, Rodriguez-Oroz M, Marin C, Alonso F, Zamarbide I, Lanciego JL, Rodriguez-Diaz M. The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits. Neurology. 62: S17-30. PMID 14718677 DOI: 10.1212/WNL.62.1_SUPPL_1.S17  0.503
2003 Rodríguez M, González J, Sabaté M, Obeso J, Pereda E. Firing regulation in dopaminergic cells: effect of the partial degeneration of nigrostriatal system in surviving neurons. The European Journal of Neuroscience. 18: 53-60. PMID 12859337 DOI: 10.1046/J.1460-9568.2003.02723.X  0.392
2002 Obeso JA, Rodríguez-Oroz MC, Rodríguez M, Arbizu J, Giménez-Amaya JM. The basal ganglia and disorders of movement: pathophysiological mechanisms. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 17: 51-5. PMID 11909992  0.336
2001 Obeso JA, Olanow CW, Rodriguez-Oroz MC, Krack P, Kumar R, Lang AE. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. The New England Journal of Medicine. 345: 956-63. PMID 11575287 DOI: 10.1056/nejmoa000827  0.416
2001 Rodríguez M, Barroso-Chinea P, Abdala P, Obeso J, González-Hernández T. Dopamine cell degeneration induced by intraventricular administration of 6-hydroxydopamine in the rat: similarities with cell loss in parkinson's disease. Experimental Neurology. 169: 163-81. PMID 11312569 DOI: 10.1006/Exnr.2000.7624  0.398
2001 Rodríguez Díaz M, Abdala P, Barroso-Chinea P, Obeso J, González-Hernández T. Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: an animal model of Parkinson's disease. Behavioural Brain Research. 122: 79-92. PMID 11287079 DOI: 10.1016/S0166-4328(01)00168-1  0.557
2001 Alvarez L, Macias R, Guridi J, Lopez G, Alvarez E, Maragoto C, Teijeiro J, Torres A, Pavon N, Rodriguez-Oroz MC, Ochoa L, Hetherington H, Juncos J, DeLong MR, Obeso JA. Dorsal subthalamotomy for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 16: 72-8. PMID 11215596 DOI: 10.1002/1531-8257(200101)16:1<72::AID-MDS1019>3.0.CO;2-6  0.364
2001 Guridi J, Obeso JA. The subthalamic nucleus, hemiballismus and Parkinson's disease: reappraisal of a neurosurgical dogma. Brain : a Journal of Neurology. 124: 5-19. PMID 11133783  0.371
2000 Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Macias R, Alvarez L, Guridi J, Vitek J, DeLong MR. Pathophysiologic basis of surgery for Parkinson's disease. Neurology. 55: S7-12. PMID 11188978  0.467
2000 Olanow CW, Brin MF, Obeso JA. The role of deep brain stimulation as a surgical treatment for Parkinson's disease. Neurology. 55: S60-6. PMID 11188977  0.396
2000 Rodriguez-Oroz MC, Gorospe A, Guridi J, Ramos E, Linazasoro G, Rodriguez-Palmero M, Obeso JA. Bilateral deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Neurology. 55: S45-51. PMID 11188975  0.357
2000 Kumar R, Lang AE, Rodriguez-Oroz MC, Lozano AM, Limousin P, Pollak P, Benabid AL, Guridi J, Ramos E, van der Linden C, Vandewalle A, Caemaert J, Lannoo E, van den Abbeele D, Vingerhoets G, ... ... Obeso JA, et al. Deep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease. Neurology. 55: S34-9. PMID 11188973  0.317
2000 Olanow CW, Obeso JA. Pulsatile stimulation of dopamine receptors and levodopa-induced motor complications in Parkinson's disease: implications for the early use of COMT inhibitors. Neurology. 55: S72-7; discussion S7. PMID 11147513  0.47
2000 Schapira AH, Obeso JA, Olanow CW. The place of COMT inhibitors in the armamentarium of drugs for the treatment of Parkinson's disease. Neurology. 55: S65-8; discussion S6. PMID 11147512  0.404
2000 Obeso JA, Rodriguez-Oroz MC, Chana P, Lera G, Rodriguez M, Olanow CW. The evolution and origin of motor complications in Parkinson's disease. Neurology. 55: S13-20; discussion S. PMID 11147505  0.458
2000 Nutt JG, Obeso JA, Stocchi F. Continuous dopamine-receptor stimulation in advanced Parkinson's disease. Trends in Neurosciences. 23: S109-15. PMID 11052228  0.407
2000 Hirsch EC, Périer C, Orieux G, François C, Féger J, Yelnik J, Vila M, Levy R, Tolosa ES, Marin C, Trinidad Herrero M, Obeso JA, Agid Y. Metabolic effects of nigrostriatal denervation in basal ganglia. Trends in Neurosciences. 23: S78-85. PMID 11052224 DOI: 10.1016/S1471-1931(00)00021-5  0.326
2000 Obeso JA, Rodríguez-Oroz MC, Rodríguez M, Lanciego JL, Artieda J, Gonzalo N, Olanow CW. Pathophysiology of the basal ganglia in Parkinson's disease. Trends in Neurosciences. 23: S8-19. PMID 11052215  0.303
2000 Obeso JA, Olanow CW, Nutt JG. Levodopa motor complications in Parkinson's disease. Trends in Neurosciences. 23: S2-7. PMID 11052214  0.377
2000 Krack P, Dowsey PL, Benabid AL, Acarin N, Benazzouz A, Künig G, Leenders KL, Obeso JA, Pollak P. Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism. Neurology. 54: 2182-4. PMID 10851392 DOI: 10.1212/Wnl.54.11.2182  0.447
2000 Jahanshahi M, Ardouin CM, Brown RG, Rothwell JC, Obeso J, Albanese A, Rodriguez-Oroz MC, Moro E, Benabid AL, Pollak P, Limousin-Dowsey P. The impact of deep brain stimulation on executive function in Parkinson's disease. Brain : a Journal of Neurology. 123: 1142-54. PMID 10825353 DOI: 10.1093/Brain/123.6.1142  0.587
2000 Olanow CW, Obeso JA. Preventing levodopa-induced dyskinesias. Annals of Neurology. 47: S167-76; discussion . PMID 10762145  0.344
2000 Obeso JA, Rodriguez-Oroz MC, Rodriguez M, DeLong MR, Olanow CW. Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model. Annals of Neurology. 47: S22-32; discussion S. PMID 10762129  0.481
2000 Obeso JA, Linazasoro G, Guridi J, Ramos E, Rodriguez-Oroz MC. High frequency stimulation of the subthalamic nucleus and levodopa induced dyskinesias in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 68: 122-3. PMID 10671136  0.313
2000 Linazasoro G, Obeso JA, Gorospe A, Rodríguez MC, Guridi J, Ramos E. Efficacy of levodopa therapy on motor function after posteroventral pallidotomy for Parkinson's disease. Neurology. 54: 535-6. PMID 10668742  0.372
2000 Obeso JA, Olanow CW, Nutt JG. Basal ganglia, Parkinson's disease and levedopa therapy Trends in Neurosciences. 23: S1. DOI: 10.1016/S1471-1931(00)00060-4  0.32
1999 Agid Y, Ahlskog E, Albanese A, Calne D, Chase T, De Yebenes J, Factor S, Fahn S, Gershanik O, Goetz C, Koller W, Kurth M, Lang A, Lees A, Lewitt P, ... ... Obeso J, et al. Levodopa in the treatment of Parkinson's disease: a consensus meeting. Movement Disorders : Official Journal of the Movement Disorder Society. 14: 911-3. PMID 10584663 DOI: 10.1002/1531-8257(199911)14:6<911::Aid-Mds1001>3.0.Co;2-H  0.335
1999 Linazasoro G, Obeso JA, Gómez JC, Martínez M, Antonini A, Leenders KL. Modification of dopamine D2 receptor activity by pergolide in Parkinson's disease: an in vivo study by PET. Clinical Neuropharmacology. 22: 277-80. PMID 10516878  0.395
1999 Guridi J, Gorospe A, Ramos E, Linazasoro G, Rodriguez MC, Obeso JA. Stereotactic targeting of the globus pallidus internus in Parkinson's disease: imaging versus electrophysiological mapping. Neurosurgery. 45: 278-87; discussion 2. PMID 10449072  0.324
1999 Brown RG, Dowsey PL, Brown P, Jahanshahi M, Pollak P, Benabid AL, Rodriguez-Oroz MC, Obeso J, Rothwell JC. Impact of deep brain stimulation on upper limb akinesia in Parkinson's disease. Annals of Neurology. 45: 473-88. PMID 10211472 DOI: 10.1002/1531-8249(199904)45:4<473::Aid-Ana9>3.0.Co;2-V  0.673
1999 Linazasoro G, Gorospe A, Rodríguez MC, Guridi J, Ramos E, Mozo A, Obeso JA. [Pallidotomy in the treatment of complicated Parkinson's disease: clinical results at two years and analysis of prognostic factors]. Neurologã­a (Barcelona, Spain). 14: 53-61. PMID 10100420  0.404
1999 Limousin P, Brown RG, Jahanshahi M, Asselman P, Quinn NP, Thomas D, Obeso JA, Rothwell JC. The effects of posteroventral pallidotomy on the preparation and execution of voluntary hand and arm movements in Parkinson's disease. Brain : a Journal of Neurology. 122: 315-27. PMID 10071059 DOI: 10.1093/Brain/122.2.315  0.526
1998 Villares J, Faucheux B, Herrero MT, Obeso JA, Duyckaerts C, Hauw JJ, Agid Y, Hirsch EC. [125I]EGF binding in basal ganglia of patients with Parkinson's disease and progressive supranuclear palsy and in MPTP-treated monkeys. Experimental Neurology. 154: 146-56. PMID 9875276 DOI: 10.1006/Exnr.1998.6933  0.37
1998 Obeso JA, Rodríguez Oroz MC, Rodríguez Díaz M. [Physiopathology of Parkinson disease]. Neurologã­a (Barcelona, Spain). 13: 19-29. PMID 9859682  0.346
1998 Rodriguez MC, Guridi OJ, Alvarez L, Mewes K, Macias R, Vitek J, DeLong MR, Obeso JA. The subthalamic nucleus and tremor in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 13: 111-8. PMID 9827606  0.451
1998 Rodriguez MC, Obeso JA, Olanow CW. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Annals of Neurology. 44: S175-88. PMID 9749591  0.393
1998 Rothwell JC, Higuchi K, Obeso JA. The offset cortical potential: an electrical correlate of movement inhibition in man. Movement Disorders : Official Journal of the Movement Disorder Society. 13: 330-5. PMID 9539349 DOI: 10.1002/mds.870130221  0.397
1997 Obeso JA, Rodríguez MC, Gorospe A, Guridi J, Alvarez L, Macias R. Surgical treatment of Parkinson's disease. Bailliã¨Re's Clinical Neurology. 6: 125-45. PMID 9426872  0.406
1997 Samuel M, Ceballos-Baumann AO, Turjanski N, Boecker H, Gorospe A, Linazasoro G, Holmes AP, DeLong MR, Vitek JL, Thomas DG, Quinn NP, Obeso JA, Brooks DJ. Pallidotomy in Parkinson's disease increases supplementary motor area and prefrontal activation during performance of volitional movements an H2(15)O PET study. Brain : a Journal of Neurology. 120: 1301-13. PMID 9278624 DOI: 10.1093/Brain/120.8.1301  0.396
1997 Burleigh-Jacobs A, Horak FB, Nutt JG, Obeso JA. Step initiation in Parkinson's disease: influence of levodopa and external sensory triggers. Movement Disorders : Official Journal of the Movement Disorder Society. 12: 206-15. PMID 9087979 DOI: 10.1002/mds.870120211  0.333
1997 Levy R, Hazrati LN, Herrero MT, Vila M, Hassani OK, Mouroux M, Ruberg M, Asensi H, Agid Y, Féger J, Obeso JA, Parent A, Hirsch EC. Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states. Neuroscience. 76: 335-43. PMID 9015319 DOI: 10.1016/S0306-4522(96)00409-5  0.416
1997 Vila M, Levy R, Herrero MT, Ruberg M, Faucheux B, Obeso JA, Agid Y, Hirsch EC. Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 765-73. PMID 8987798  0.345
1997 Vila M, Levy R, Herrero M, Ruberg M, Faucheux B, Obeso JA, Agid Y, Hirsch EC. Consequences of Nigrostriatal Denervation on the Functioning of the Basal Ganglia in Human and Nonhuman Primates: AnIn SituHybridization Study of Cytochrome Oxidase Subunit I mRNA The Journal of Neuroscience. 17: 765-773. DOI: 10.1523/JNEUROSCI.17-02-00765.1997  0.332
1996 Obeso JA, Linazasoro G, Rothwell JC, Jahanshahi M, Brown R. Assessing the effects of pallidotomy in Parkinson's disease. Lancet. 347: 1490. PMID 8676663 DOI: 10.1016/S0140-6736(96)91728-6  0.628
1996 Vila M, Herrero MT, Levy R, Faucheux B, Ruberg M, Guillen J, Luquin MR, Guridi J, Javoy-Agid F, Agid Y, Obeso JA, Hirsch EC. Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes. Neurology. 46: 802-9. PMID 8618687 DOI: 10.1212/WNL.46.3.802  0.431
1995 Faucheux BA, Herrero MT, Villares J, Levy R, Javoy-Agid F, Obeso JA, Hauw JJ, Agid Y, Hirsch EC. Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys. Brain Research. 691: 115-24. PMID 8590043 DOI: 10.1016/0006-8993(95)00629-5  0.332
1995 Obeso JA, Guridi J, Linazasoro G, Ramos E. Hemiballism in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 58: 645-7. PMID 7745426  0.34
1995 Obeso JA, Lera G. Cabergoline in Parkinson's disease Neurology. 45: 1234-1234. DOI: 10.1212/wnl.45.6.1234-a  0.34
1994 Rodriguez M, Lera G, Vaamonde J, Luquin MR, Obeso JA. Motor response to apomorphine and levodopa in asymmetric Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 57: 562-6. PMID 8201324  0.445
1994 Rodríguez M, Artieda J, Zubieta JL, Obeso JA. [Olivopontocerebellar atrophy and Parkinson's disease: diagnostic problems]. Neurologã­a (Barcelona, Spain). 9: 4-11. PMID 8161468  0.399
1994 Pérez-Otaño I, Oset C, Luquin MR, Herrero MT, Obeso JA, Del Río J. MPTP-induced parkinsonism in primates: pattern of striatal dopamine loss following acute and chronic administration. Neuroscience Letters. 175: 121-5. PMID 7970192  0.35
1994 Obeso JA, Grandas F, Herrero MT, Horowski R. The role of pulsatile versus continuous dopamine receptor stimulation for functional recovery in Parkinson's disease. The European Journal of Neuroscience. 6: 889-97. PMID 7952277  0.423
1994 Marsden CD, Obeso JA. The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease. Brain : a Journal of Neurology. 117: 877-97. PMID 7922472  0.373
1994 Ceballos-Baumann AO, Obeso JA, Vitek JL, Delong MR, Bakay R, Linazasoro G, Brooks DJ. Restoration of thalamocortical activity after posteroventral pallidotomy in Parkinson's disease. Lancet (London, England). 344: 814. PMID 7916090 DOI: 10.1016/S0140-6736(94)92369-8  0.329
1994 Kastner A, Herrero MT, Hirsch EC, Guillen J, Luquin MR, Javoy-Agid F, Obeso JA, Agid Y. Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy. Annals of Neurology. 36: 206-14. PMID 7914399 DOI: 10.1002/ana.410360213  0.3
1994 Guridi J, Herrero MT, Luquin R, Guillen J, Obeso JA. Subthalamotomy improves MPTP-induced parkinsonism in monkeys. Stereotactic and Functional Neurosurgery. 62: 98-102. PMID 7631095  0.362
1993 Herrero MT, Kastner A, Perez-Otaño I, Hirsch EC, Luquin MR, Javoy-Agid F, Del Río J, Obeso JA, Agid Y. Gangliosides and parkinsonism. Neurology. 43: 2132-4. PMID 8413979 DOI: 10.1212/Wnl.43.10.2132  0.347
1993 Vaamonde J, Legarda I, Jimenez-Jimenez J, Zubieta JL, Obeso JA. Levodopa-responsive parkinsonism associated with basal ganglia calcification and primary hypoparathyroidism. Movement Disorders : Official Journal of the Movement Disorder Society. 8: 398-400. PMID 8341314 DOI: 10.1002/mds.870080332  0.324
1993 Guridi J, Luquin MR, Herrero MT, Obeso JA. The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 8: 421-9. PMID 8232351 DOI: 10.1002/mds.870080402  0.428
1993 Herrero MT, Perez-Otaño I, Oset C, Kastner A, Hirsch EC, Agid Y, Luquin MR, Obeso JA, Del Rio J. GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys. Neuroscience. 56: 965-72. PMID 7904332 DOI: 10.1016/0306-4522(93)90142-3  0.326
1992 Pastor MA, Jahanshahi M, Artieda J, Obeso JA. Performance of repetitive wrist movements in Parkinson's disease. Brain : a Journal of Neurology. 115: 875-91. PMID 1628206 DOI: 10.1093/Brain/115.3.875  0.564
1992 Grandas F, Gancher ST, Rodriguez M, Lera G, Nutt JG, Obeso JA. Differences in the motor response to apomorphine between untreated and fluctuating patients with Parkinson's disease. Clinical Neuropharmacology. 15: 13-8. PMID 1576595  0.317
1992 Pastor MA, Artieda J, Jahanshahi M, Obeso JA. Time estimation and reproduction is abnormal in Parkinson's disease. Brain : a Journal of Neurology. 115: 211-25. PMID 1559155 DOI: 10.1093/Brain/115.1.211  0.547
1992 Artieda J, Pastor MA, Lacruz F, Obeso JA. Temporal discrimination is abnormal in Parkinson's disease. Brain : a Journal of Neurology. 115: 199-210. PMID 1559154  0.411
1992 Herrero MT, Luquín MR, Obeso JA. [Experimental model of Parkinson disease: mechanisms and anatomo- pathological characteristics of MPTP neurotoxicity]. Archivos De Neurobiologiã¡. 55: 175-82. PMID 1417423  0.325
1992 Grandas F, Luquin MR, Rodríguez M, Vaamonde J, Lera G, Obeso JA. [Motor fluctuations in Parkinson disease: risk factors]. Neurologã­a (Barcelona, Spain). 7: 89-93. PMID 1389297  0.376
1992 Pérez-Otaño I, Herrero MT, Luquin MR, Obeso JA, Del Río J. Chronic MPTP treatment reduces substance P and met-enkephalin content in the basal ganglia of the marmoset. Brain Research. 585: 156-60. PMID 1380867  0.313
1992 Luquin MR, Scipioni O, Vaamonde J, Gershanik O, Obeso JA. Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. Movement Disorders : Official Journal of the Movement Disorder Society. 7: 117-24. PMID 1350058 DOI: 10.1002/Mds.870070204  0.442
1992 Obeso JA, Luquin MR, Grandas F, Vaamonde J, Laguna J, Martinez-Lage JM. Motor response to repeated dopaminergic stimulation in Parkinson's disease. Clinical Neuropharmacology. 15: 75-9. PMID 1349508  0.491
1992 LUQIN MR, LAGUNA J, PEREZ-OTA??O I, GUILLEN J, OBESO JA. THE AMPA ANTAGONIST NBQX DOES NOT ALTER THE MOTOR RESPONSE INDUCED BY SELECTIVE DOPAMINE AGONISTS IN MPTP-MONKEYS Behavioural Pharmacology. 3: 79. DOI: 10.1097/00008877-199204001-00243  0.357
1991 Obeso JA, Artieda J, Martinez-Lage JM. Dopaminergic photosensitivity. Neurology. 41: 612. PMID 1901398  0.374
1991 Pérez-Otaño I, Herrero MT, Oset C, De Ceballos ML, Luquin MR, Obeso JA, Del Río J. Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset. Brain Research. 567: 127-32. PMID 1815820  0.34
1991 Obeso JA, Luquín MR, Artieda J, Herrero MT, Pastor MA, Guridi J. [Anatomo-functional basis for Parkinson's disease]. Archivos De Neurobiologiã¡. 54: 272-6. PMID 1811458  0.318
1991 Luquin MR, Obeso JA, Herrero MT, Laguna J, Martínez-Lage JM. [Parkinsonism induced by MPTP as an experimental model of Parkinson disease: similarities and differences]. Neurologã­a (Barcelona, Spain). 6: 287-94. PMID 1790005  0.453
1990 Vaamonde J, Luquin MR, Obeso JA. Dopaminergic responsiveness to apomorphine after chronic treatment with subcutaneous lisuride infusion in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 5: 260-2. PMID 2388647 DOI: 10.1002/mds.870050316  0.35
1990 Nakashima K, Rothwell JC, Thompson PD, Day BL, Berardelli A, Agostino R, Artieda J, Papas SM, Obeso JA, Marsden CD. The blink reflex in patients with idiopathic torsion dystonia. Archives of Neurology. 47: 413-6. PMID 2322135 DOI: 10.1001/Archneur.1990.00530040055019  0.493
1990 Lera G, Vaamonde J, Muruzabal J, Obeso JA. Cabergoline: a long-acting dopamine agonist in Parkinson's disease. Annals of Neurology. 28: 593-4. PMID 2252377 DOI: 10.1002/ana.410280428  0.38
1989 Vaamonde J, Luquin MR, Obeso JA. Levodopa consumption reduces dopaminergic receptor responsiveness in Parkinson's disease. Clinical Neuropharmacology. 12: 271-84. PMID 2804991  0.432
1989 Grandas F, Obeso JA. Motor response following repeated apomorphine administration is reduced in Parkinson's disease. Clinical Neuropharmacology. 12: 14-22. PMID 2713864  0.451
1989 Obeso JA, Grandas F, Vaamonde J, Luquin MR, Artieda J, Lera G, Rodriguez ME, Martinez-Lage JM. Motor complications associated with chronic levodopa therapy in Parkinson's disease. Neurology. 39: 11-9. PMID 2685647  0.412
1988 Obeso JA, Luquin MR, Vaamonde J, Grandas F, Martinez Lage JM. Continuous dopaminergic stimulation in Parkinson's disease. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 14: 488-92. PMID 3676922 DOI: 10.1017/S0317167100037963  0.447
1988 Gershanik OS, Luquin MR, Scipioni O, Obeso JA. Isoniazid therapy in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 3: 133-9. PMID 3221901 DOI: 10.1002/mds.870030205  0.326
1987 Martí Massó JF, Obeso JA, Carrera N, Martínez-Lage JM. Aggravation of Parkinson's disease by cinnarizine. Journal of Neurology, Neurosurgery, and Psychiatry. 50: 804-5. PMID 3302112 DOI: 10.1136/JNNP.50.6.804  0.352
1987 Obeso JA, Grandas F, Vaamonde J, Rosario Luguin M, Martínez-Lage JM. Apomorphine infusion for motor fluctuations in Parkinson's disease. Lancet (London, England). 1: 1376-7. PMID 2884483 DOI: 10.1016/S0140-6736(87)90679-9  0.436
1986 Obeso JA, Luquin MR, Martínez Lage JM. Intravenous lisuride corrects oscillations of motor performance in Parkinson's disease. Annals of Neurology. 19: 31-5. PMID 3947037 DOI: 10.1002/ANA.410190107  0.36
1986 Obeso JA, Luquin MR, Martínez-Lage JM. Lisuride infusion pump: a device for the treatment of motor fluctuations in Parkinson's disease. Lancet (London, England). 1: 467-70. PMID 2869209 DOI: 10.1016/S0140-6736(86)92929-6  0.415
1983 Marsden CD, Obeso JA, Rothwell JC. The function of the antagonist muscle during fast limb movements in man. The Journal of Physiology. 335: 1-13. PMID 6875870 DOI: 10.1113/jphysiol.1983.sp014514  0.369
1983 Obeso JA, Martinez-Lage JM, Luquin MR, Bolio N. Intravenous lisuride infusion for Parkinson's disease. Annals of Neurology. 14: 252. PMID 6625541 DOI: 10.1002/ANA.410140213  0.343
1982 Rothwell JC, Traub MM, Day BL, Obeso JA, Thomas PK, Marsden CD. Manual motor performance in a deafferented man. Brain : a Journal of Neurology. 105: 515-42. PMID 6286035 DOI: 10.1093/Brain/105.3.515  0.415
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