Jean-Philippe Pin - Publications

Institute for Functional Genomics, Montpellier, Occitanie, France 
Neuropharmacology, mGlu and GABAB receptors

235 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sebastianutto I, Goyet E, Andreoli L, Font-Ingles J, Moreno-Delgado D, Bouquier N, Jahannault-Talignani C, Moutin E, Di Menna L, Maslava N, Pin JP, Fagni L, Nicoletti F, Ango F, Cenci MA, et al. D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease. The Journal of Clinical Investigation. PMID 32039920 DOI: 10.1172/JCI126361  0.32
2019 Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, et al. LSP5-2157 a new inhibitor of vesicular glutamate transporters. Neuropharmacology. 107902. PMID 31811873 DOI: 10.1016/j.neuropharm.2019.107902  0.4
2019 Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prezeau L. Non-classical ligand-independent regulation of Go protein by an orphan Class C GPCR. Molecular Pharmacology. PMID 31189666 DOI: 10.1124/mol.118.113019  0.56
2019 Heuninck J, Hounsou C, Dupuis E, Trinquet E, Mouillac B, Pin JP, Bonnet D, Durroux T. Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology. Methods in Molecular Biology (Clifton, N.J.). 1947: 151-168. PMID 30969415 DOI: 10.1007/978-1-4939-9121-1_8  0.36
2019 Pin JP, Kniazeff J, Prézeau L, Liu JF, Rondard P. GPCR interaction as a possible way for allosteric control between receptors. Molecular and Cellular Endocrinology. PMID 30849406 DOI: 10.1016/j.mce.2019.02.019  0.4
2019 Zindel D, Vol C, Lecha O, Bequignon I, Bilgic M, Vereecke M, Charrier-Savournin F, Romier M, Trinquet E, Pin JP, Pannequin J, Roux T, Dupuis E, Prézeau L. HTRF Total and Phospho-YAP (Ser127) Cellular Assays. Methods in Molecular Biology (Clifton, N.J.). 1893: 153-166. PMID 30565133 DOI: 10.1007/978-1-4939-8910-2_13  0.4
2018 Tora AS, Rovira X, Cao AM, Cabayé A, Olofsson L, Malhaire F, Scholler P, Baik H, Van Eeckhaut A, Smolders I, Rondard P, Margeat E, Acher F, Pin JP, Goudet C. Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3. Neuropharmacology. 140: 275-286. PMID 30102917 DOI: 10.1016/j.neuropharm.2018.08.011  0.44
2018 Belhocine A, Veglianese P, Hounsou C, Dupuis E, Acher F, Durroux T, Goudet C, Pin JP. Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite assays. Neuropharmacology. 140: 233-245. PMID 30099051 DOI: 10.1016/j.neuropharm.2018.07.032  0.44
2018 Møller TC, Hottin J, Clerté C, Zwier JM, Durroux T, Rondard P, Prézeau L, Royer CA, Pin JP, Margeat E, Kniazeff J. Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics. Scientific Reports. 8: 10414. PMID 29991736 DOI: 10.1038/s41598-018-28682-6  0.4
2018 Chelliah S, Lemasson IA, Brabet I, Oueslati N, Karaman B, Cabaye A, Tora AEL, Commare B, Courtiol T, Cesarini S, McCort-Tranchepain I, Rigault D, Mony L, Bessiron T, McLean H, ... ... Pin JP, et al. Increased potency and selectivity for group-III metabotropic glutamate receptor agonists binding at dual sites. Journal of Medicinal Chemistry. PMID 29397723 DOI: 10.1021/acs.jmedchem.7b01438  0.44
2018 Font J, López-Cano M, Notartomaso S, Scarselli P, Di Prieto P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, et al. Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 7. PMID 29313801 DOI: 10.7554/eLife.34752  0.44
2018 Stewart GD, Comps-Agrar L, Nørskov-Lauritsen LB, Pin JP, Kniazeff J. Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers. Neuropharmacology. PMID 29305121 DOI: 10.1016/j.neuropharm.2017.12.042  0.36
2017 Liu J, Zhang Z, Moreno-Delgado D, Dalton JA, Rovira X, Trapero A, Goudet C, Llebaria A, Giraldo J, Yuan Q, Rondard P, Huang S, Liu J, Pin JP. Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer. Elife. 6. PMID 28829739 DOI: 10.7554/eLife.26985  0.44
2017 Moreno Delgado D, Møller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP. Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells. Elife. 6. PMID 28661401 DOI: 10.7554/eLife.25233  0.56
2017 Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, et al. Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 6. PMID 28395733 DOI: 10.7554/eLife.23545  0.44
2017 Lecat-Guillet N, Monnier C, Rovira X, Kniazeff J, Lamarque L, Zwier JM, Trinquet E, Pin JP, Rondard P. FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor. Cell Chemical Biology. PMID 28286129 DOI: 10.1016/j.chembiol.2017.02.011  0.36
2017 Gómez-Santacana X, Pittolo S, Rovira X, Lopez M, Zussy C, Dalton JA, Faucherre A, Jopling C, Pin JP, Ciruela F, Goudet C, Giraldo J, Gorostiza P, Llebaria A. Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals. Acs Central Science. 3: 81-91. PMID 28149957 DOI: 10.1021/acscentsci.6b00353  0.44
2017 Gómez-Santacana X, Dalton JA, Rovira X, Pin JP, Goudet C, Gorostiza P, Giraldo J, Llebaria A. Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation. European Journal of Medicinal Chemistry. 127: 567-576. PMID 28109949 DOI: 10.1016/j.ejmech.2017.01.013  0.44
2016 Pin JP, Bettler B. Organization and functions of mGlu and GABAB receptor complexes. Nature. 540: 60-68. PMID 27905440 DOI: 10.1038/nature20566  1
2016 ZIndel D, Engel S, Bottrill AR, Pin JP, Prézeau L, Tobin AB, Bünemann M, Krasel C, Butcher AJ. Identification of key phosphorylation sites in PTH1R which determine arrestin3 binding and fine tune receptor signaling. The Biochemical Journal. PMID 27623777 DOI: 10.1042/BCJ20160740  0.4
2016 Rovira X, Trapero A, Pittolo S, Zussy C, Faucherre A, Jopling C, Giraldo J, Pin JP, Gorostiza P, Goudet C, Llebaria A. OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity. Cell Chemical Biology. PMID 27478159 DOI: 10.1016/j.chembiol.2016.06.013  0.44
2016 Huynh TH, Erichsen MN, Tora AS, Goudet C, Sagot E, Assaf Z, Thomsen C, Brodbeck R, Stensbøl TB, Bjørn-Yoshimoto WE, Nielsen B, Pin JP, Gefflaut T, Bunch L. New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. Journal of Medicinal Chemistry. PMID 26814576 DOI: 10.1021/acs.jmedchem.5b01333  0.44
2015 Dalton JA, Lans I, Rovira X, Malhaire F, Santacana XG, Pittolo S, Gorostiza P, Llebaria A, Goudet C, Pin JP, Giraldo J. Shining Light On An mGlu5 Photoswitchable NAM: A Theoretical Perspective. Current Neuropharmacology. PMID 26391742  0.44
2015 Vischer HF, Castro M, Pin JP. G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches. Molecular Pharmacology. 88: 561-71. PMID 26138074 DOI: 10.1124/mol.115.099440  0.56
2015 Tora AS, Rovira X, Dione I, Bertrand HO, Brabet I, De Koninck Y, Doyon N, Pin JP, Acher F, Goudet C. Allosteric modulation of metabotropic glutamate receptors by chloride ions. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 4174-88. PMID 26116702 DOI: 10.1096/fj.14-269746  0.56
2015 Zhang Z, Zhang W, Huang S, Sun Q, Wang Y, Hu Y, Sun N, Zhang Y, Jiang Z, Minato N, Pin JP, Su L, Liu J. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. Journal of Cell Science. 128: 2302-13. PMID 25967549 DOI: 10.1242/jcs.167056  0.56
2015 Ivashkin P, Lemonnier G, Tora AS, Pin JP, Goudet C, Jubault P, Pannecoucke X. Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers. Bioorganic & Medicinal Chemistry Letters. 25: 2523-6. PMID 25958247 DOI: 10.1016/j.bmcl.2015.04.043  0.56
2015 Faklaris O, Cottet M, Falco A, Villier B, Laget M, Zwier JM, Trinquet E, Mouillac B, Pin JP, Durroux T. Multicolor time-resolved Förster resonance energy transfer microscopy reveals the impact of GPCR oligomerization on internalization processes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2235-46. PMID 25690655 DOI: 10.1096/fj.14-260059  0.56
2015 Paoletti P, Pin JP. Editorial overview: neurosciences: targeting glutamatergic signaling in CNS diseases: new hopes? Current Opinion in Pharmacology. 20: iv-vi. PMID 25601440 DOI: 10.1016/j.coph.2015.01.001  0.56
2015 Oueslati N, Hounsou C, Belhocine A, Rodriguez T, Dupuis E, Zwier JM, Trinquet E, Pin JP, Durroux T. Time-resolved FRET strategy to screen GPCR ligand library. Methods in Molecular Biology (Clifton, N.J.). 1272: 23-36. PMID 25563174 DOI: 10.1007/978-1-4939-2336-6_2  0.56
2015 Isberg V, de Graaf C, Bortolato A, Cherezov V, Katritch V, Marshall FH, Mordalski S, Pin JP, Stevens RC, Vriend G, Gloriam DE. Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends in Pharmacological Sciences. 36: 22-31. PMID 25541108 DOI: 10.1016/  0.56
2015 Rondard P, Pin JP. Dynamics and modulation of metabotropic glutamate receptors. Current Opinion in Pharmacology. 20: 95-101. PMID 25529199 DOI: 10.1016/j.coph.2014.12.001  0.56
2015 Xue L, Rovira X, Scholler P, Zhao H, Liu J, Pin JP, Rondard P. Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer. Nature Chemical Biology. 11: 134-40. PMID 25503927 DOI: 10.1038/nchembio.1711  0.56
2015 Commare B, Rigault D, Lemasson IA, Deschamps P, Tomas A, Roussel P, Brabet I, Goudet C, Pin JP, Leroux FR, Colobert F, Acher FC. Determination of the absolute configuration of phosphinic analogues of glutamate. Organic & Biomolecular Chemistry. 13: 1106-12. PMID 25417857 DOI: 10.1039/c4ob01960a  0.56
2015 Fernández-Dueñas V, Taura JJ, Cottet M, Gómez-Soler M, López-Cano M, Ledent C, Watanabe M, Trinquet E, Pin JP, Luján R, Durroux T, Ciruela F. Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats. Disease Models & Mechanisms. 8: 57-63. PMID 25398851 DOI: 10.1242/dmm.018143  0.36
2015 Hounsou C, Margathe JF, Oueslati N, Belhocine A, Dupuis E, Thomas C, Mann A, Ilien B, Rognan D, Trinquet E, Hibert M, Pin JP, Bonnet D, Durroux T. Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer. Acs Chemical Biology. 10: 466-74. PMID 25350273 DOI: 10.1021/cb5007568  0.56
2015 Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C. Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 116-30. PMID 25342125 DOI: 10.1096/fj.14-257287  0.56
2014 Olofsson L, Felekyan S, Doumazane E, Scholler P, Fabre L, Zwier JM, Rondard P, Seidel CA, Pin JP, Margeat E. Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy. Nature Communications. 5: 5206. PMID 25323157 DOI: 10.1038/ncomms6206  0.56
2014 Rovira X, Harrak Y, Trapero A, González-Bulnes P, Malhaire F, Pin JP, Goudet C, Giraldo J, Llebaria A. Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor. Chemmedchem. 9: 2685-98. PMID 25196639 DOI: 10.1002/cmdc.201402190  0.56
2014 Pittolo S, Gómez-Santacana X, Eckelt K, Rovira X, Dalton J, Goudet C, Pin JP, Llobet A, Giraldo J, Llebaria A, Gorostiza P. An allosteric modulator to control endogenous G protein-coupled receptors with light. Nature Chemical Biology. 10: 813-5. PMID 25173999 DOI: 10.1038/nchembio.1612  0.56
2014 Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Prézeau L, Bouvier M. The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4509-23. PMID 25053617 DOI: 10.1096/fj.13-242446  0.56
2014 Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ. International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacological Reviews. 66: 918-47. PMID 25026896 DOI: 10.1124/pr.114.008862  0.56
2014 Ayoub MA, Trebaux J, Vallaghe J, Charrier-Savournin F, Al-Hosaini K, Gonzalez Moya A, Pin JP, Pfleger KD, Trinquet E. Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format. Frontiers in Endocrinology. 5: 94. PMID 25002860 DOI: 10.3389/fendo.2014.00094  0.56
2014 Sbai O, Monnier C, Dodé C, Pin JP, Hardelin JP, Rondard P. Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3734-44. PMID 24830383 DOI: 10.1096/fj.13-243402  0.56
2014 Xu C, Zhang W, Rondard P, Pin JP, Liu J. Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor. Frontiers in Pharmacology. 5: 12. PMID 24575041 DOI: 10.3389/fphar.2014.00012  0.56
2014 Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X. G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacological Reviews. 66: 413-34. PMID 24515647 DOI: 10.1124/pr.113.008052  0.56
2014 Bjordal M, Arquier N, Kniazeff J, Pin JP, Léopold P. Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Cell. 156: 510-21. PMID 24485457 DOI: 10.1016/j.cell.2013.12.024  0.56
2014 Gómez-Santacana X, Rovira X, Dalton JA, Goudet C, Pin JP, Gorostiza P, Giraldo J, Llebaria A. A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5 Medchemcomm. 5: 1548-1554. DOI: 10.1039/c4md00208c  0.44
2013 Ayoub MA, Pin JP. Interaction of Protease-Activated Receptor 2 with G Proteins and β-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer. Frontiers in Endocrinology. 4: 196. PMID 24391627 DOI: 10.3389/fendo.2013.00196  0.56
2013 Vilar B, Busserolles J, Ling B, Laffray S, Ulmann L, Malhaire F, Chapuy E, Aissouni Y, Etienne M, Bourinet E, Acher F, Pin JP, Eschalier A, Goudet C. Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18951-65. PMID 24285900 DOI: 10.1523/JNEUROSCI.1221-13.2013  0.56
2013 Ivankova K, Turecek R, Fritzius T, Seddik R, Prezeau L, Comps-Agrar L, Pin JP, Fakler B, Besseyrias V, Gassmann M, Bettler B. Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12). The Journal of Biological Chemistry. 288: 24848-56. PMID 23843457 DOI: 10.1074/jbc.M113.476770  0.56
2013 Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacological Reviews. 65: 967-86. PMID 23686350 DOI: 10.1124/pr.112.007179  0.56
2013 Pin JP. Tuning synaptic activity with light-controlled GPCRs. Nature Neuroscience. 16: 377-9. PMID 23528934 DOI: 10.1038/nn.3363  0.56
2013 Doumazane E, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P. Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: E1416-25. PMID 23487753 DOI: 10.1073/pnas.1215615110  0.56
2013 Cottet M, Faklaris O, Falco A, Trinquet E, Pin JP, Mouillac B, Durroux T. Fluorescent ligands to investigate GPCR binding properties and oligomerization. Biochemical Society Transactions. 41: 148-53. PMID 23356275 DOI: 10.1042/BST20120237  0.56
2013 Scholler P, Zwier JM, Trinquet E, Rondard P, Pin JP, Prézeau L, Kniazeff J. Time-resolved Förster resonance energy transfer-based technologies to investigate G protein-coupled receptor machinery: high-throughput screening assays and future development. Progress in Molecular Biology and Translational Science. 113: 275-312. PMID 23244793 DOI: 10.1016/B978-0-12-386932-6.00007-7  0.56
2013 Amalric M, Lopez S, Goudet C, Fisone G, Battaglia G, Nicoletti F, Pin JP, Acher FC. Group III and subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease. Neuropharmacology. 66: 53-64. PMID 22664304 DOI: 10.1016/j.neuropharm.2012.05.026  0.56
2012 Kniazeff J, Pin JP. [G-protein-coupled receptors dimers and oligomers: for which purpose? The GABA(B) receptor under investigation]. MéDecine Sciences : M/S. 28: 858-63. PMID 23067417 DOI: 10.1051/medsci/20122810014  0.56
2012 El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Banères JL, Rondard P, Pin JP. Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling. Proceedings of the National Academy of Sciences of the United States of America. 109: 16342-7. PMID 22988116 DOI: 10.1073/pnas.1205838109  0.56
2012 Hlavackova V, Zabel U, Frankova D, Bätz J, Hoffmann C, Prezeau L, Pin JP, Blahos J, Lohse MJ. Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Science Signaling. 5: ra59. PMID 22894836 DOI: 10.1126/scisignal.2002720  0.56
2012 Cottet M, Faklaris O, Maurel D, Scholler P, Doumazane E, Trinquet E, Pin JP, Durroux T. BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues. Frontiers in Endocrinology. 3: 92. PMID 22837753 DOI: 10.3389/fendo.2012.00092  0.56
2012 Lemonnier G, Lion C, Quirion JC, Pin JP, Goudet C, Jubault P. Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4. Bioorganic & Medicinal Chemistry. 20: 4716-26. PMID 22750138 DOI: 10.1016/j.bmc.2012.06.006  0.56
2012 Ayoub MA, Al-Senaidy A, Pin JP. Receptor-G protein interaction studied by bioluminescence resonance energy transfer: lessons from protease-activated receptor 1. Frontiers in Endocrinology. 3: 82. PMID 22737145 DOI: 10.3389/fendo.2012.00082  0.56
2012 Geng Y, Xiong D, Mosyak L, Malito DL, Kniazeff J, Chen Y, Burmakina S, Quick M, Bush M, Javitch JA, Pin JP, Fan QR. Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nature Neuroscience. 15: 970-8. PMID 22660477 DOI: 10.1038/nn.3133  0.56
2012 Comps-Agrar L, Kniazeff J, Brock C, Trinquet E, Pin JP. Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3430-9. PMID 22613777 DOI: 10.1096/fj.12-203646  0.56
2012 Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology. 81: 643-56. PMID 22311707 DOI: 10.1124/mol.111.074765  0.56
2012 Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, McLean H, Daniel H, Amalric M, Acher F, Pin JP. A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1682-93. PMID 22223752 DOI: 10.1096/fj.11-195941  0.56
2011 Tallet E, Fernandez I, Zhang C, Salsac M, Gregor N, Ayoub MA, Pin JP, Trinquet E, Goffin V. Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer. Frontiers in Endocrinology. 2: 29. PMID 22649370 DOI: 10.3389/fendo.2011.00029  0.56
2011 Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P. Interdomain movements in metabotropic glutamate receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 108: 15480-5. PMID 21896740 DOI: 10.1073/pnas.1107775108  0.56
2011 Comps-Agrar L, Maurel D, Rondard P, Pin JP, Trinquet E, Prézeau L. Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to G protein-coupled receptor oligomerization. Methods in Molecular Biology (Clifton, N.J.). 756: 201-14. PMID 21870227 DOI: 10.1007/978-1-61779-160-4_10  0.56
2011 Cottet M, Albizu L, Comps-Agrar L, Trinquet E, Pin JP, Mouillac B, Durroux T. Time resolved FRET strategy with fluorescent ligands to analyze receptor interactions in native tissues: application to GPCR oligomerization. Methods in Molecular Biology (Clifton, N.J.). 746: 373-87. PMID 21607869 DOI: 10.1007/978-1-61779-126-0_21  0.56
2011 Comps-Agrar L, Kniazeff J, Nørskov-Lauritsen L, Maurel D, Gassmann M, Gregor N, Prézeau L, Bettler B, Durroux T, Trinquet E, Pin JP. The oligomeric state sets GABA(B) receptor signalling efficacy. The Embo Journal. 30: 2336-49. PMID 21552208 DOI: 10.1038/emboj.2011.143  0.56
2011 Kniazeff J, Prézeau L, Rondard P, Pin JP, Goudet C. Dimers and beyond: The functional puzzles of class C GPCRs. Pharmacology & Therapeutics. 130: 9-25. PMID 21256155 DOI: 10.1016/j.pharmthera.2011.01.006  0.56
2011 Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S. G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient. The Journal of Biological Chemistry. 286: 9985-97. PMID 21247891 DOI: 10.1074/jbc.M110.201939  0.56
2011 Christov C, González-Bulnes P, Malhaire F, Karabencheva T, Goudet C, Pin JP, Llebaria A, Giraldo J. Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4. Chemmedchem. 6: 131-40. PMID 21132834 DOI: 10.1002/cmdc.201000378  0.56
2011 Monnier C, Tu H, Bourrier E, Vol C, Lamarque L, Trinquet E, Pin JP, Rondard P. Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation. The Embo Journal. 30: 32-42. PMID 21063387 DOI: 10.1038/emboj.2010.270  0.56
2011 Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP. Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology. 60: 1017-41. PMID 21036182 DOI: 10.1016/j.neuropharm.2010.10.022  0.56
2011 Doumazane E, Scholler P, Zwier JM, Trinquet E, Rondard P, Pin JP. A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 66-77. PMID 20826542 DOI: 10.1096/fj.10-163147  0.56
2011 Collingridge GL, Pin JP, Hubbard RE, Kiss JP, Spedding M. Introduction to the special issue on High Resolution Neuropharmacology. Neuropharmacology. 60: 1-2. PMID 20813115 DOI: 10.1016/j.neuropharm.2010.08.020  0.56
2011 Rondard P, Goudet C, Kniazeff J, Pin JP, Prézeau L. The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors. Neuropharmacology. 60: 82-92. PMID 20713070 DOI: 10.1016/j.neuropharm.2010.08.009  0.56
2011 Acher FC, Selvam C, Pin JP, Goudet C, Bertrand HO. A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design. Neuropharmacology. 60: 102-7. PMID 20621106 DOI: 10.1016/j.neuropharm.2010.07.002  0.56
2011 Cottet M, Faklaris O, Zwier JM, Trinquet E, Pin JP, Durroux T. Original fluorescent ligand-based assays open new perspectives in G-protein coupled receptor drug screening Pharmaceuticals. 4: 202-214. DOI: 10.3390/ph4010202  0.56
2011 Prézeau L, Rondard P, Goudet C, Kniazeff J, Pin JP. Class C receptor activation mechanisms illustrated by mGlu and GABA B receptors. A review. Flavour and Fragrance Journal. 26: 218-222. DOI: 10.1002/ffj.2044  0.56
2010 Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, ... ... Pin JP, et al. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nature Chemical Biology. 6: 587-94. PMID 20622858 DOI: 10.1038/nchembio.396  0.56
2010 Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, ... Pin JP, et al. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England). 26: 1804-5. PMID 20501551 DOI: 10.1093/bioinformatics/btq264  0.56
2010 Ayoub MA, Trinquet E, Pfleger KD, Pin JP. Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 3522-35. PMID 20410441 DOI: 10.1096/fj.10-154997  0.56
2010 Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nature Neuroscience. 13: 622-9. PMID 20383137 DOI: 10.1038/nn.2529  0.56
2010 Martín R, Durroux T, Ciruela F, Torres M, Pin JP, Sánchez-Prieto J. The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. The Journal of Biological Chemistry. 285: 17907-17. PMID 20375012 DOI: 10.1074/jbc.M109.080838  0.56
2010 Selvam C, Oueslati N, Lemasson IA, Brabet I, Rigault D, Courtiol T, Cesarini S, Triballeau N, Bertrand HO, Goudet C, Pin JP, Acher FC. A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. Journal of Medicinal Chemistry. 53: 2797-813. PMID 20218620 DOI: 10.1021/jm901523t  0.56
2010 Tu H, Xu C, Zhang W, Liu Q, Rondard P, Pin JP, Liu J. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 749-59. PMID 20071540 DOI: 10.1523/JNEUROSCI.2343-09.2010  0.56
2010 Rovira X, Pin JP, Giraldo J. The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Trends in Pharmacological Sciences. 31: 15-21. PMID 19963287 DOI: 10.1016/  0.56
2010 Prezeau L, Rives ML, Comps-Agrar L, Maurel D, Kniazeff J, Pin JP. Functional crosstalk between GPCRs: with or without oligomerization. Current Opinion in Pharmacology. 10: 6-13. PMID 19962942 DOI: 10.1016/j.coph.2009.10.009  0.56
2010 Pin JP, Maurel D, Comps-Agrar L, Monnier C, Rives ML, Doumazane E, Rondard P, Durroux T, Prézeau L, Trinquet E. Time-resolved FRET approaches to study GPCR complexes G Protein-Coupled Receptors: Structure, Signaling, and Physiology. 67-89. DOI: 10.1017/CBO9780511760334.005  0.4
2009 Pin JP, Comps-Agrar L, Maurel D, Monnier C, Rives ML, Trinquet E, Kniazeff J, Rondard P, Prézeau L. G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABAB receptors. The Journal of Physiology. 587: 5337-44. PMID 19723778 DOI: 10.1113/jphysiol.2009.179978  0.56
2009 Ayoub MA, Damian M, Gespach C, Ferrandis E, Lavergne O, De Wever O, Banères JL, Pin JP, Prévost GP. Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit. The Journal of Biological Chemistry. 284: 29136-45. PMID 19648112 DOI: 10.1074/jbc.M109.042333  0.56
2009 Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub MA, Shigemoto R, Pin JP, Prézeau L. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. The Embo Journal. 28: 2195-208. PMID 19590495 DOI: 10.1038/emboj.2009.177  0.56
2009 Beurrier C, Lopez S, Révy D, Selvam C, Goudet C, Lhérondel M, Gubellini P, Kerkerian-LeGoff L, Acher F, Pin JP, Amalric M. Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3619-28. PMID 19525404 DOI: 10.1096/fj.09-131789  0.56
2009 Cuomo D, Martella G, Barabino E, Platania P, Vita D, Madeo G, Selvam C, Goudet C, Oueslati N, Pin JP, Acher F, Pisani A, Beurrier C, Melon C, Kerkerian-Le Goff L, et al. Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment. Journal of Neurochemistry. 109: 1096-105. PMID 19519781 DOI: 10.1111/j.1471-4159.2009.06036.x  0.56
2009 Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue DJ, Gauthier M, Pin JP, Dissous C. A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. Plos One. 4: e5651. PMID 19461966 DOI: 10.1371/journal.pone.0005651  0.56
2009 Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, et al. Building a new conceptual framework for receptor heteromers. Nature Chemical Biology. 5: 131-4. PMID 19219011 DOI: 10.1038/nchembio0309-131  0.56
2009 Goudet C, Magnaghi V, Landry M, Nagy F, Gereau RW, Pin JP. Metabotropic receptors for glutamate and GABA in pain. Brain Research Reviews. 60: 43-56. PMID 19146876 DOI: 10.1016/j.brainresrev.2008.12.007  0.56
2009 Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, ... ... Pin JP, et al. IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Research. 37: D680-5. PMID 18948278 DOI: 10.1093/nar/gkn728  0.56
2009 Monnier C, Dodé C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, Rondard P. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Human Molecular Genetics. 18: 75-81. PMID 18826963 DOI: 10.1093/hmg/ddn318  0.56
2008 Kumpost J, Syrova Z, Kulihova L, Frankova D, Bologna JC, Hlavackova V, Prezeau L, Kralikova M, Hruskova B, Pin JP, Blahos J. Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells. Neuropharmacology. 55: 409-18. PMID 18627772 DOI: 10.1016/j.neuropharm.2008.06.073  0.56
2008 Damian M, Mary S, Martin A, Pin JP, Banères JL. G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation. The Journal of Biological Chemistry. 283: 21084-92. PMID 18490452 DOI: 10.1074/jbc.M710419200  0.56
2008 Maurel D, Comps-Agrar L, Brock C, Rives ML, Bourrier E, Ayoub MA, Bazin H, Tinel N, Durroux T, Prézeau L, Trinquet E, Pin JP. Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization. Nature Methods. 5: 561-7. PMID 18488035 DOI: 10.1038/nmeth.1213  0.56
2008 Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu J. Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. The Embo Journal. 27: 1321-32. PMID 18388862 DOI: 10.1038/emboj.2008.64  0.56
2008 Rovira X, Roche D, Serra J, Kniazeff J, Pin JP, Giraldo J. Modeling the binding and function of metabotropic glutamate receptors. The Journal of Pharmacology and Experimental Therapeutics. 325: 443-56. PMID 18287211 DOI: 10.1124/jpet.107.133967  0.56
2008 Chen Y, Goudet C, Pin JP, Conn PJ. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Molecular Pharmacology. 73: 909-18. PMID 18056795 DOI: 10.1124/mol.107.040097  0.56
2008 Goudet C, Chapuy E, Alloui A, Acher F, Pin JP, Eschalier A. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain. 137: 112-24. PMID 17900808 DOI: 10.1016/j.pain.2007.08.020  0.56
2008 Pin JP, Ayoub MA, Maurel D, Perroy J, Trinquet E. Energy Transfer Technologies to Monitor the Dynamics and Signaling Properties of G-Protein-Coupled Receptors in Living Cells Biophysical Analysis of Membrane Proteins: Investigating Structure and Function. 309-334. DOI: 10.1002/9783527621224.ch13  0.56
2007 Pin JP, Prézeau L. Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective. Current Neuropharmacology. 5: 195-201. PMID 19305802 DOI: 10.2174/157015907781695919  0.56
2007 Brock C, Oueslati N, Soler S, Boudier L, Rondard P, Pin JP. Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. The Journal of Biological Chemistry. 282: 33000-8. PMID 17855348 DOI: 10.1074/jbc.M702542200  0.56
2007 Selvam C, Goudet C, Oueslati N, Pin JP, Acher FC. L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency. Journal of Medicinal Chemistry. 50: 4656-64. PMID 17722902 DOI: 10.1021/jm070400y  0.56
2007 Sibille P, Lopez S, Brabet I, Valenti O, Oueslati N, Gaven F, Goudet C, Bertrand HO, Neyton J, Marino MJ, Amalric M, Pin JP, Acher FC. Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. Journal of Medicinal Chemistry. 50: 3585-95. PMID 17602546 DOI: 10.1021/jm070262c  0.56
2007 Tu H, Rondard P, Xu C, Bertaso F, Cao F, Zhang X, Pin JP, Liu J. Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. Cellular Signalling. 19: 1996-2002. PMID 17582742 DOI: 10.1016/j.cellsig.2007.05.004  0.56
2007 Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. Bmc Bioinformatics. 8: 177. PMID 17537266 DOI: 10.1186/1471-2105-8-177  0.56
2007 Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/pr.59.1.5  0.56
2007 Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, Pin JP, Prézeau L. Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors. The Journal of Biological Chemistry. 282: 12154-63. PMID 17310064 DOI: 10.1074/jbc.M611071200  0.56
2007 Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Molecular Pharmacology. 71: 1389-98. PMID 17303702 DOI: 10.1124/mol.106.032425  0.56
2007 Ayoub MA, Maurel D, Binet V, Fink M, Prézeau L, Ansanay H, Pin JP. Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. Molecular Pharmacology. 71: 1329-40. PMID 17267663 DOI: 10.1124/mol.106.030304  0.56
2007 Frauli M, Hubert N, Schann S, Triballeau N, Bertrand HO, Acher F, Neuville P, Pin JP, Prézeau L. Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism. Molecular Pharmacology. 71: 704-12. PMID 17167031 DOI: 10.1124/mol.106.030254  0.56
2006 Damian M, Martin A, Mesnier D, Pin JP, Banères JL. Asymmetric conformational changes in a GPCR dimer controlled by G-proteins. The Embo Journal. 25: 5693-702. PMID 17139258 DOI: 10.1038/sj.emboj.7601449  0.56
2006 Trinquet E, Fink M, Bazin H, Grillet F, Maurin F, Bourrier E, Ansanay H, Leroy C, Michaud A, Durroux T, Maurel D, Malhaire F, Goudet C, Pin JP, Naval M, et al. D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Analytical Biochemistry. 358: 126-35. PMID 16965760 DOI: 10.1016/j.ab.2006.08.002  0.56
2006 Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M. Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Biochemical and Biophysical Research Communications. 349: 471-9. PMID 16945339 DOI: 10.1016/j.bbrc.2006.07.216  0.56
2006 Albizu L, Balestre MN, Breton C, Pin JP, Manning M, Mouillac B, Barberis C, Durroux T. Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding. Molecular Pharmacology. 70: 1783-91. PMID 16926282 DOI: 10.1124/mol.106.025684  0.56
2006 Rondard P, Liu J, Huang S, Malhaire F, Vol C, Pinault A, Labesse G, Pin JP. Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. The Journal of Biological Chemistry. 281: 24653-61. PMID 16787923 DOI: 10.1074/jbc.M602277200  0.56
2006 Frauli M, Neuville P, Vol C, Pin JP, Prézeau L. Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors. Neuropharmacology. 50: 245-53. PMID 16310227 DOI: 10.1016/j.neuropharm.2005.09.016  0.56
2005 Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacological Reviews. 57: 541-6. PMID 16382107 DOI: 10.1124/pr.57.4.1  0.56
2005 Brock C, Boudier L, Maurel D, Blahos J, Pin JP. Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3. Molecular Biology of the Cell. 16: 5572-8. PMID 16176975 DOI: 10.1091/mbc.E05-05-0400  0.56
2005 Pin JP, Kniazeff J, Liu J, Binet V, Goudet C, Rondard P, Prézeau L. Allosteric functioning of dimeric class C G-protein-coupled receptors. The Febs Journal. 272: 2947-55. PMID 15955055 DOI: 10.1111/j.1742-4658.2005.04728.x  0.56
2005 Goudet C, Kniazeff J, Hlavackova V, Malhaire F, Maurel D, Acher F, Blahos J, Prézeau L, Pin JP. Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. The Journal of Biological Chemistry. 280: 24380-5. PMID 15863499 DOI: 10.1074/jbc.M502642200  0.48
2005 Triballeau N, Acher F, Brabet I, Pin JP, Bertrand HO. Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4. Journal of Medicinal Chemistry. 48: 2534-47. PMID 15801843 DOI: 10.1021/jm049092j  0.4
2005 Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prézeau L, Pin JP, Blahos J. Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. The Embo Journal. 24: 499-509. PMID 15660124 DOI: 10.1038/sj.emboj.7600557  0.48
2004 Binet V, Goudet C, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L. Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator. Biochemical Society Transactions. 32: 871-2. PMID 15494037 DOI: 10.1042/BST0320871  0.44
2004 Pin JP, Kniazeff J, Binet V, Liu J, Maurel D, Galvez T, Duthey B, Havlickova M, Blahos J, Prézeau L, Rondard P. Activation mechanism of the heterodimeric GABA(B) receptor. Biochemical Pharmacology. 68: 1565-72. PMID 15451400 DOI: 10.1016/j.bcp.2004.06.035  0.56
2004 Kniazeff J, Bessis AS, Maurel D, Ansanay H, Prézeau L, Pin JP. Closed state of both binding domains of homodimeric mGlu receptors is required for full activity. Nature Structural & Molecular Biology. 11: 706-13. PMID 15235591 DOI: 10.1038/nsmb794  0.36
2004 Pin JP, Kniazeff J, Goudet C, Bessis AS, Liu J, Galvez T, Acher F, Rondard P, Prézeau L. The activation mechanism of class-C G-protein coupled receptors. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 96: 335-42. PMID 15207901 DOI: 10.1016/j.biolcel.2004.03.005  0.56
2004 Maurel D, Kniazeff J, Mathis G, Trinquet E, Pin JP, Ansanay H. Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology. Analytical Biochemistry. 329: 253-62. PMID 15158484 DOI: 10.1016/j.ab.2004.02.013  0.36
2004 Liu J, Maurel D, Etzol S, Brabet I, Ansanay H, Pin JP, Rondard P. Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit. The Journal of Biological Chemistry. 279: 15824-30. PMID 14736871 DOI: 10.1074/jbc.M313639200  0.56
2004 Kniazeff J, Saintot PP, Goudet C, Liu J, Charnet A, Guillon G, Pin JP. Locking the dimeric GABA(B) G-protein-coupled receptor in its active state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 370-7. PMID 14724235 DOI: 10.1523/JNEUROSCI.3141-03.2004  0.56
2004 Goudet C, Gaven F, Kniazeff J, Vol C, Liu J, Cohen-Gonsaud M, Acher F, Prézeau L, Pin JP. Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 378-83. PMID 14691258 DOI: 10.1073/pnas.0304699101  0.44
2004 Mitri C, Parmentier ML, Pin JP, Bockaert J, Grau Y. Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects. The Journal of Biological Chemistry. 279: 9313-20. PMID 14660580 DOI: 10.1074/jbc.M310878200  0.52
2003 Galvez T, Pin JP. [How do G-protein-coupled receptors work? The case of metabotropic glutamate and GABA receptors]. MéDecine Sciences : M/S. 19: 559-65. PMID 12836389 DOI: 10.1051/medsci/2003195559  0.4
2003 Havlickova M, Blahos J, Brabet I, Liu J, Hruskova B, Prézeau L, Pin JP. The second intracellular loop of metabotropic glutamate receptors recognizes C termini of G-protein alpha-subunits. The Journal of Biological Chemistry. 278: 35063-70. PMID 12829705 DOI: 10.1074/jbc.M306555200  0.48
2003 Pin JP, Galvez T, Prézeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacology & Therapeutics. 98: 325-54. PMID 12782243  0.4
2003 Fourgeaud L, Bessis AS, Rossignol F, Pin JP, Olivo-Marin JC, Hémar A. The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway. The Journal of Biological Chemistry. 278: 12222-30. PMID 12529370 DOI: 10.1074/jbc.M205663200  0.56
2002 Pin JP, Acher F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Current Drug Targets. Cns and Neurological Disorders. 1: 297-317. PMID 12769621 DOI: 10.1016/B978-0-12-397032-9.00012-1  0.56
2002 Kniazeff J, Galvez T, Labesse G, Pin JP. No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7352-61. PMID 12196556  0.4
2002 Bessis AS, Rondard P, Gaven F, Brabet I, Triballeau N, Prezeau L, Acher F, Pin JP. Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proceedings of the National Academy of Sciences of the United States of America. 99: 11097-102. PMID 12151600 DOI: 10.1073/pnas.162138699  0.56
2002 Havlickova M, Prezeau L, Duthey B, Bettler B, Pin JP, Blahos J. The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Molecular Pharmacology. 62: 343-50. PMID 12130687 DOI: 10.1124/mol.62.2.343  0.56
2002 Bertrand HO, Bessis AS, Pin JP, Acher FC. Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. Journal of Medicinal Chemistry. 45: 3171-83. PMID 12109902  0.4
2002 Ango F, Robbe D, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Molecular and Cellular Neurosciences. 20: 323-9. PMID 12093163 DOI: 10.1006/mcne.2002.1100  0.56
2002 Parmentier ML, Prézeau L, Bockaert J, Pin JP. A model for the functioning of family 3 GPCRs. Trends in Pharmacological Sciences. 23: 268-74. PMID 12084632  0.52
2002 Perroy J, El Far O, Bertaso F, Pin JP, Betz H, Bockaert J, Fagni L. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. The Embo Journal. 21: 2990-9. PMID 12065412 DOI: 10.1093/emboj/cdf313  0.56
2002 Gasparini F, Kuhn R, Pin JP. Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives. Current Opinion in Pharmacology. 2: 43-9. PMID 11786307  0.32
2002 Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prézeau L. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. The Journal of Biological Chemistry. 277: 3236-41. PMID 11711539 DOI: 10.1074/jbc.M108900200  0.56
2001 Pin JP, Parmentier ML, Prézeau L. Positive allosteric modulators for gamma-aminobutyric acid(B) receptors open new routes for the development of drugs targeting family 3 G-protein-coupled receptors. Molecular Pharmacology. 60: 881-4. PMID 11641414  0.32
2001 Perroy J, Gutierrez GJ, Coulon V, Bockaert J, Pin JP, Fagni L. The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways. The Journal of Biological Chemistry. 276: 45800-5. PMID 11584003 DOI: 10.1074/jbc.M106876200  0.52
2001 Ango F, Prézeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature. 411: 962-5. PMID 11418862 DOI: 10.1038/35082096  0.56
2001 Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L, Pin JP. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. The Embo Journal. 20: 2152-9. PMID 11331581 DOI: 10.1093/emboj/20.9.2152  0.56
2001 Carroll FY, Stolle A, Beart PM, Voerste A, Brabet I, Mauler F, Joly C, Antonicek H, Bockaert J, Müller T, Pin JP, Prézeau L. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Molecular Pharmacology. 59: 965-73. PMID 11306677  0.56
2001 Costantino G, Maltoni K, Marinozzi M, Camaioni E, Prezeau L, Pin JP, Pellicciari R. Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist. Bioorganic & Medicinal Chemistry. 9: 221-7. PMID 11249114 DOI: 10.1016/S0968-0896(00)00270-4  0.56
2001 Blahos J, Fischer T, Brabet I, Stauffer D, Rovelli G, Bockaert J, Pin JP. A novel site on the Galpha -protein that recognizes heptahelical receptors. The Journal of Biological Chemistry. 276: 3262-9. PMID 11027680 DOI: 10.1074/jbc.M004880200  0.52
2000 Bessis AS, Bertrand HO, Galvez T, De Colle C, Pin JP, Acher F. Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process. Protein Science : a Publication of the Protein Society. 9: 2200-9. PMID 11152130 DOI: 10.1110/ps.9.11.2200  0.4
2000 Ango F, Pin JP, Tu JC, Xiao B, Worley PF, Bockaert J, Fagni L. Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8710-6. PMID 11102477  0.56
2000 Galvez T, Prezeau L, Milioti G, Franek M, Joly C, Froestl W, Bettler B, Bertrand HO, Blahos J, Pin JP. Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors. The Journal of Biological Chemistry. 275: 41166-74. PMID 10986293 DOI: 10.1074/jbc.M007848200  0.56
2000 Pagano A, Ruegg D, Litschig S, Stoehr N, Stierlin C, Heinrich M, Floersheim P, Prezèau L, Carroll F, Pin JP, Cambria A, Vranesic I, Flor PJ, Gasparini F, Kuhn R. The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors. The Journal of Biological Chemistry. 275: 33750-8. PMID 10934211 DOI: 10.1074/jbc.M006230200  0.56
2000 De Colle C, Bessis AS, Bockaert J, Acher F, Pin JP. Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. European Journal of Pharmacology. 394: 17-26. PMID 10771029  0.52
2000 Parmentier ML, Galvez T, Acher F, Peyre B, Pellicciari R, Grau Y, Bockaert J, Pin JP. Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution. Neuropharmacology. 39: 1119-31. PMID 10760355 DOI: 10.1016/S0028-3908(99)00204-X  0.56
2000 Galvez T, Urwyler S, Prézeau L, Mosbacher J, Joly C, Malitschek B, Heid J, Brabet I, Froestl W, Bettler B, Kaupmann K, Pin JP. Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit. Molecular Pharmacology. 57: 419-26. PMID 10692480  0.56
1999 Franek M, Pagano A, Kaupmann K, Bettler B, Pin JP, Blahos J. The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-termini. Neuropharmacology. 38: 1657-66. PMID 10587081 DOI: 10.1016/S0028-3908(99)00135-5  0.56
1999 Lafon-Cazal M, Viennois G, Kuhn R, Malitschek B, Pin JP, Shigemoto R, Bockaert J. mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones. Neuropharmacology. 38: 1631-40. PMID 10530824 DOI: 10.1016/S0028-3908(99)00124-0  0.56
1999 Ango F, Albani-Torregrossa S, Joly C, Robbe D, Michel JM, Pin JP, Bockaert J, Fagni L. A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells. Neuropharmacology. 38: 793-803. PMID 10465683  0.52
1999 Pfaff T, Malitschek B, Kaupmann K, Prézeau L, Pin JP, Bettler B, Karschin A. Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor. The European Journal of Neuroscience. 11: 2874-82. PMID 10457184 DOI: 10.1046/j.1460-9568.1999.00704.x  0.56
1999 Malitschek B, Schweizer C, Keir M, Heid J, Froestl W, Mosbacher J, Kuhn R, Henley J, Joly C, Pin JP, Kaupmann K, Bettler B. The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding. Molecular Pharmacology. 56: 448-54. PMID 10419566  0.32
1999 Galvez T, Parmentier ML, Joly C, Malitschek B, Kaupmann K, Kuhn R, Bittiger H, Froestl W, Bettler B, Pin JP. Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding. The Journal of Biological Chemistry. 274: 13362-9. PMID 10224098 DOI: 10.1074/jbc.274.19.13362  0.56
1999 Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. The Embo Journal. 18: 1723-9. PMID 10202136 DOI: 10.1093/emboj/18.7.1723  0.52
1999 Lafon-Cazal M, Fagni L, Guiraud MJ, Mary S, Lerner-Natoli M, Pin JP, Shigemoto R, Bockaert J. mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons. The European Journal of Neuroscience. 11: 663-72. PMID 10051767  0.52
1999 Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Molecular Pharmacology. 55: 453-61. PMID 10051528  0.56
1998 Corti C, Restituito S, Rimland JM, Brabet I, Corsi M, Pin JP, Ferraguti F. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. The European Journal of Neuroscience. 10: 3629-41. PMID 9875342 DOI: 10.1046/j.1460-9568.1998.00371.x  0.56
1998 Pellicciari R, Costantino G, Giovagnoni E, Mattoli L, Brabet I, Pin JP. Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist. Bioorganic & Medicinal Chemistry Letters. 8: 1569-74. PMID 9873392 DOI: 10.1016/S0960-894X(98)00265-0  0.56
1998 Brabet I, Parmentier ML, De Colle C, Bockaert J, Acher F, Pin JP. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology. 37: 1043-51. PMID 9833633  0.52
1998 Bockaert J, Pin JP. [Use of a G-protein-coupled receptor to communicate. An evolutionary success]. Comptes Rendus De L'AcadéMie Des Sciences. SéRie Iii, Sciences De La Vie. 321: 529-51. PMID 9769853  0.52
1998 Copani A, Casabona G, Bruno V, Caruso A, Condorelli DF, Messina A, Di Giorgi Gerevini V, Pin JP, Kuhn R, Knöpfel T, Nicoletti F. The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons. The European Journal of Neuroscience. 10: 2173-84. PMID 9753103  0.32
1998 Blahos J, Mary S, Perroy J, de Colle C, Brabet I, Bockaert J, Pin JP. Extreme C terminus of G protein alpha-subunits contains a site that discriminates between Gi-coupled metabotropic glutamate receptors. The Journal of Biological Chemistry. 273: 25765-9. PMID 9748247  0.52
1998 Parmentier ML, Joly C, Restituito S, Bockaert J, Grau Y, Pin JP. The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain. Molecular Pharmacology. 53: 778-86. PMID 9547371  0.56
1998 Mary S, Gomeza J, Prézeau L, Bockaert J, Pin JP. A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C. The Journal of Biological Chemistry. 273: 425-32. PMID 9417099  0.52
1997 Mary S, Stephan D, Gomeza J, Bockaert J, Pruss RM, Pin JP. The rat mGlu1d receptor splice variant shares functional properties with the other short isoforms of mGlu1 receptor. European Journal of Pharmacology. 335: 65-72. PMID 9371547  0.52
1997 Acher FC, Tellier FJ, Azerad R, Brabet IN, Fagni L, Pin JP. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. Journal of Medicinal Chemistry. 40: 3119-29. PMID 9301676 DOI: 10.1021/jm970207b  0.32
1997 Todeschi N, Gharbi-Benarous J, Acher F, Larue V, Pin JP, Bockaert J, Azerad R, Girault JP. Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists. Bioorganic & Medicinal Chemistry. 5: 335-52. PMID 9061198  0.52
1996 Gomeza J, Mary S, Brabet I, Parmentier ML, Restituito S, Bockaert J, Pin JP. Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. Molecular Pharmacology. 50: 923-30. PMID 8863838  0.56
1996 Parmentier ML, Pin JP, Bockaert J, Grau Y. Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6687-94. PMID 8824309  0.52
1996 Manahan-Vaughan D, Reiser M, Pin JP, Wilsch V, Bockaert J, Reymann KG, Riedel G. Physiological and pharmacological profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience. 72: 999-1008. PMID 8735225 DOI: 10.1016/0306-4522(95)00594-3  0.56
1996 Flor PJ, Gomeza J, Tones MA, Kuhn R, Pin JP, Knöpfel T. The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists. Journal of Neurochemistry. 67: 58-63. PMID 8667026  0.56
1996 Prézeau L, Gomeza J, Ahern S, Mary S, Galvez T, Bockaert J, Pin JP. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. Molecular Pharmacology. 49: 422-9. PMID 8643081  0.52
1996 Gomeza J, Joly C, Kuhn R, Knöpfel T, Bockaert J, Pin JP. The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. The Journal of Biological Chemistry. 271: 2199-205. PMID 8567679  0.56
1995 Brabet I, Mary S, Bockaert J, Pin JP. Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Neuropharmacology. 34: 895-903. PMID 8532171  0.52
1995 Pin JP, Gomeza J, Joly C, Bockaert J. The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specificity. Biochemical Society Transactions. 23: 91-6. PMID 7758811  0.52
1995 Joly C, Gomeza J, Brabet I, Curry K, Bockaert J, Pin JP. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3970-81. PMID 7751958  0.56
1995 Pin JP, Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34: 1-26. PMID 7623957 DOI: 10.1016/0028-3908(94)00129-G  0.56
1995 Pin JP, Bockaert J. Get receptive to metabotropic glutamate receptors. Current Opinion in Neurobiology. 5: 342-9. PMID 7580157  0.52
1994 Pin JP, Joly C, Heinemann SF, Bockaert J. Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors. The Embo Journal. 13: 342-8. PMID 8313879  0.56
1994 Prézeau L, Carrette J, Helpap B, Curry K, Pin JP, Bockaert J. Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Molecular Pharmacology. 45: 570-7. PMID 8183235  0.52
1994 Didier M, Mienville JM, Soubrié P, Bockaert J, Berman S, Bursztajn S, Pin JP. Plasticity of NMDA receptor expression during mouse cerebellar granule cell development. The European Journal of Neuroscience. 6: 1536-43. PMID 7850018  0.52
1993 Didier M, Héaulme M, Gonalons N, Soubrié P, Bockaert J, Pin JP. 35 mM K(+)-stimulated 45Ca2+ uptake in cerebellar granule cell cultures mainly results from NMDA receptor activation. European Journal of Pharmacology. 244: 57-65. PMID 7678398  0.52
1992 Lafon-Cazal M, Bougault I, Steinberg R, Pin JP, Bockaert J. Measurement of gamma-enolase release, a new method for selective quantification of neurotoxicity independently from glial lysis. Brain Research. 593: 63-8. PMID 1458320  0.52
1992 Pin JP, Waeber C, Prezeau L, Bockaert J, Heinemann SF. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 89: 10331-5. PMID 1438218  0.56
1992 Sladeczek F, Manzoni O, Fagni L, Dumuis A, Pin JP, Sebben M, Bockaert J. The metabotropic glutamate receptor (MGR): pharmacology and subcellular location. Journal of Physiology, Paris. 86: 47-55. PMID 1343596  0.52
1992 Didier M, Roux P, Piechaczyk M, Mangeat P, Devilliers G, Bockaert J, Pin JP. Long-term expression of the c-fos protein during the in vitro differentiation of cerebellar granule cells induced by potassium or NMDA. Brain Research. Molecular Brain Research. 12: 249-58. PMID 1312204  0.52
1991 Oomagari K, Buisson B, Dumuis A, Bockaert J, Pin JP. Effect of Glutamate and Ionomycin on the Release of Arachidonic Acid, Prostaglandins and HETEs from Cultured Neurons and Astrocytes. The European Journal of Neuroscience. 3: 928-939. PMID 12106250  0.52
1990 Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J. (trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes. Molecular Pharmacology. 38: 1-6. PMID 2164627  0.52
1990 Rassendren FA, Lory P, Pin JP, Nargeot J. Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes. Neuron. 4: 733-40. PMID 2160837 DOI: 10.1016/0896-6273(90)90199-P  0.56
1990 Pin JP, Bockaert J. Omega-conotoxin GVIA and dihydropyridines discriminate two types of Ca2+ channels involved in GABA release from striatal neurons in culture. European Journal of Pharmacology. 188: 81-4. PMID 2155125  0.52
1990 Bockaert J, Dumuis A, Manzoni O, Nargeot J, Oomagari K, Pin JP, Rassendren F, Sebben M, Sladeczek F. Intracellular messengers associated with excitatory amino acid (EAA) receptors. Advances in Experimental Medicine and Biology. 268: 79-91. PMID 1981654  0.52
1990 Charpentier N, Dumuis A, Sebben M, Bockaert J, Pin JP. On concanavalin A-treated striatal neurons quisqualate clearly behaves as a partial agonist of a receptor fully activated by kainate. European Journal of Pharmacology. 189: 241-51. PMID 1980646  0.52
1990 Didier M, Heaulme M, Soubrié P, Bockaert J, Pin JP. Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells. Journal of Neuroscience Research. 27: 25-35. PMID 1979352 DOI: 10.1002/jnr.490270105  0.52
1990 Dumuis A, Pin JP, Oomagari K, Sebben M, Bockaert J. Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors. Nature. 347: 182-4. PMID 1975645 DOI: 10.1038/347182a0  0.52
1989 Pin JP, Bockaert J. Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 648-56. PMID 2918382  0.52
1989 Didier M, Roux P, Piechaczyk M, Verrier B, Bockaert J, Pin JP. Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression. Neuroscience Letters. 107: 55-62. PMID 2575730  0.52
1989 Van Vliet BJ, Sebben M, Dumuis A, Gabrion J, Bockaert J, Pin JP. Endogenous amino acid release from cultured cerebellar neuronal cells: effect of tetanus toxin on glutamate release. Journal of Neurochemistry. 52: 1229-39. PMID 2564424  0.52
1989 Pin JP, Van Vliet BJ, Bockaert J. Complex interaction between quisqualate and kainate receptors as revealed by measurement of GABA release from striatal neurons in primary culture. European Journal of Pharmacology. 172: 81-91. PMID 2541001  0.52
1989 Rassendren FA, Lory P, Pin JP, Bockaert J, Nargeot J. A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNA. Neuroscience Letters. 99: 333-9. PMID 2471121 DOI: 10.1016/0304-3940(89)90469-2  0.56
1988 Pin JP, Van-Vliet BJ, Bockaert J. NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine. Neuroscience Letters. 87: 87-92. PMID 2898115  0.52
1988 Dumuis A, Sebben M, Haynes L, Pin JP, Bockaert J. NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature. 336: 68-70. PMID 2847054 DOI: 10.1038/336068a0  0.52
1988 Pin JP, Yasumoto T, Bockaert J. Maitotoxin-evoked gamma-aminobutyric acid release is due not only to the opening of calcium channels. Journal of Neurochemistry. 50: 1227-32. PMID 2450172  0.52
1987 Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neuroscience Letters. 74: 211-6. PMID 2883610 DOI: 10.1016/0304-3940(87)90151-0  0.56
1987 Pin JP, Rumigny JF, Bockaert J, Recasens M. Multiple Cl(-)-independent binding sites for the excitatory amino acids: glutamate, aspartate and cysteine sulfinate in rat brain membranes. Brain Research. 402: 11-20. PMID 2881598 DOI: 10.1016/0006-8993(87)91042-0  0.56
1987 Pin JP, Bockaert J. Multiple voltage-sensitive calcium channels are probably involved in endogenous GABA release from striatal neurones differentiated in primary culture. Naunyn-Schmiedeberg's Archives of Pharmacology. 336: 190-6. PMID 2446149  0.52
1986 Weiss S, Pin JP, Sebben M, Kemp DE, Sladeczek F, Gabrion J, Bockaert J. Synaptogenesis of cultured striatal neurons in serum-free medium: a morphological and biochemical study. Proceedings of the National Academy of Sciences of the United States of America. 83: 2238-42. PMID 3008155  0.52
1986 Bockaert J, Gabrion J, Sladeczek F, Pin JP, Recasens M, Sebben M, Kemp D, Dumuis A, Weiss S. Primary culture of striatal neurons: a model of choice for pharmacological and biochemical studies of neurotransmitter receptors. Journal De Physiologie. 81: 219-27. PMID 2883308  0.52
1986 Pin JP, Bockaert J, Recasens M. The binding of acidic amino acids to snail, Helix aspersa, periesophagic ring membranes reveals a single high-affinity glutamate/kainate site. Brain Research. 366: 290-9. PMID 2870764 DOI: 10.1016/0006-8993(86)91306-5  0.56
1986 Pin JP, Weiss S, Sebben M, Kemp DE, Bockaert J. Release of endogenous amino acids from striatal neurons in primary culture. Journal of Neurochemistry. 47: 594-603. PMID 2426401  0.52
1985 Sladeczek F, Pin JP, Récasens M, Bockaert J, Weiss S. Glutamate stimulates inositol phosphate formation in striatal neurones. Nature. 317: 717-9. PMID 2865680 DOI: 10.1038/317717a0  0.56
1984 Pin JP, Bockaert J, Recasesn M. The Ca2+/C1- dependent L-[3H]glutamate binding: a new receptor or a particular transport process? Febs Letters. 175: 31-6. PMID 6090209  0.52
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