| Year |
Citation |
Score |
| 2022 |
Panda DK, Bai X, Zhang Y, Stylianesis NA, Koromilas AE, Lipman ML, Karaplis AC. SCF-SKP2 E3 ubiquitin ligase links mTORC1-ER stress-ISR with YAP activation in murine renal cystogenesis. The Journal of Clinical Investigation. PMID 36326820 DOI: 10.1172/JCI153943 |
0.424 |
|
| 2022 |
Koromilas AE. The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200026. PMID 35587163 DOI: 10.1002/bies.202200026 |
0.374 |
|
| 2020 |
Jewer M, Lee L, Leibovitch M, Zhang G, Liu J, Findlay SD, Vincent KM, Tandoc K, Dieters-Castator D, Quail DF, Dutta I, Coatham M, Xu Z, Puri A, Guan BJ, ... ... Koromilas A, et al. Translational control of breast cancer plasticity. Nature Communications. 11: 2498. PMID 32427827 DOI: 10.1038/S41467-020-16352-Z |
0.382 |
|
| 2019 |
Darini C, Ghaddar N, Chabot C, Assaker G, Sabri S, Wang S, Krishnamoorthy J, Buchanan M, Aguilar-Mahecha A, Abdulkarim B, Deschenes J, Torres J, Ursini-Siegel J, Basik M, Koromilas AE. An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy. Nature Communications. 10: 2139. PMID 31086176 DOI: 10.1038/S41467-019-10138-8 |
0.399 |
|
| 2018 |
Koromilas AE. M(en)TORship lessons on life and death by the integrated stress response. Biochimica Et Biophysica Acta. General Subjects. PMID 30572003 DOI: 10.1016/J.Bbagen.2018.12.009 |
0.423 |
|
| 2018 |
Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A, Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE. Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells. Cell Death & Disease. 9: 254. PMID 29449538 DOI: 10.1038/S41419-018-0326-2 |
0.488 |
|
| 2018 |
Panda D, Bai X, Sabbagh Y, Zhang Y, Zaun HC, Karellis A, Koromilas AE, Lipman M, Karaplis AC. Defective Interplay Between mTORC1 Activity and Endoplasmic Reticulum Stress-Unfolded Protein Response in Uremic Vascular Calcification. American Journal of Physiology. Renal Physiology. PMID 29357413 DOI: 10.1152/Ajprenal.00350.2017 |
0.428 |
|
| 2017 |
Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, et al. A Unique ISR Program Determines Cellular Responses to Chronic Stress. Molecular Cell. 68: 885-900.e6. PMID 29220654 DOI: 10.1016/J.Molcel.2017.11.007 |
0.418 |
|
| 2017 |
Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J. The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression. Nature Communications. 8: 14638. PMID 28276425 DOI: 10.1038/Ncomms14638 |
0.398 |
|
| 2016 |
Goldberg AA, Nkengfac B, Sanchez AM, Moroz N, Qureshi ST, Koromilas AE, Wang S, Burelle Y, Hussain SN, Kristof AS. Regulation of ULK1 expression and autophagy by STAT1. The Journal of Biological Chemistry. PMID 28011640 DOI: 10.1074/Jbc.M116.771584 |
0.531 |
|
| 2016 |
Farabaugh KT, Majumder M, Guan BJ, Jobava R, Wu J, Krokowski D, Gao XH, Schuster A, Longworth M, Chan ED, Bianchi M, Dey M, Koromilas AE, Ramakrishnan P, Hatzoglou M. PKR mediates inflammatory response induced by hyperosmotic stress. Molecular and Cellular Biology. PMID 27920257 DOI: 10.1128/Mcb.00521-16 |
0.46 |
|
| 2016 |
Wang S, Darini C, Désaubry L, Koromilas AE. STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A. Molecular Cancer Therapeutics. 15: 3055-3063. PMID 27913706 DOI: 10.1158/1535-7163.Mct-16-0416 |
0.456 |
|
| 2016 |
Podszywalow-Bartnicka P, Cmoch A, Wolczyk M, Bugajski L, Tkaczyk M, Dadlez M, Nieborowska-Skorska M, Koromilas AE, Skorski T, Piwocka K. Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes. Oncotarget. PMID 27802179 DOI: 10.18632/Oncotarget.12941 |
0.452 |
|
| 2016 |
Mahboubi H, Koromilas A, Stochaj U. AMP-kinase Activation Alters Oxidant-induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Molecular Pharmacology. PMID 27430620 DOI: 10.1124/Mol.116.105494 |
0.535 |
|
| 2016 |
Rajesh K, Krishnamoorthy J, Gupta J, Kazimierczak U, Papadakis AI, Deng Z, Wang S, Kuninaka S, Koromilas AE. The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress. Oncotarget. PMID 27409837 DOI: 10.18632/Oncotarget.10480 |
0.509 |
|
| 2016 |
Wang S, Koromilas AE. STAT1-mediated translational control in tumor suppression and antitumor therapies. Molecular & Cellular Oncology. 3: e1055049. PMID 27314074 DOI: 10.1080/23723556.2015.1055049 |
0.407 |
|
| 2016 |
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nature Communications. 7: 11127. PMID 27040916 DOI: 10.1038/Ncomms11127 |
0.471 |
|
| 2016 |
Booth L, Roberts JL, Tavallai M, Chuckalovcak J, Stringer DK, Koromilas AE, Boone DL, McGuire WP, Poklepovic A, Dent P. [Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling. Oncotarget. PMID 27015562 DOI: 10.18632/Oncotarget.8281 |
0.438 |
|
| 2015 |
Zismanov V, Chichkov V, Colangelo V, Jamet S, Wang S, Syme A, Koromilas AE, Crist C. Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal. Cell Stem Cell. PMID 26549106 DOI: 10.1016/J.Stem.2015.09.020 |
0.358 |
|
| 2015 |
Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE. mTORC2 balances Akt activation and eIF2alpha serine 51 phosphorylation to promote survival under stress. Molecular Cancer Research : McR. PMID 26130148 DOI: 10.1158/1541-7786.Mcr-15-0184-T |
0.549 |
|
| 2015 |
Wang S, Patsis C, Koromilas AE. Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs. Proceedings of the National Academy of Sciences of the United States of America. 112: E2149-55. PMID 25870277 DOI: 10.1073/Pnas.1420671112 |
0.536 |
|
| 2015 |
Rajesh K, Krishnamoorthy J, Kazimierczak U, Tenkerian C, Papadakis AI, Wang S, Huang S, Koromilas AE. Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress. Cell Death & Disease. 6: e1591. PMID 25590801 DOI: 10.1038/Cddis.2014.554 |
0.529 |
|
| 2015 |
Koromilas AE. Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment. Biochimica Et Biophysica Acta. 1849: 871-80. PMID 25497381 DOI: 10.1016/J.Bbagrm.2014.12.007 |
0.529 |
|
| 2015 |
Koromilas A, Tenkerian C, Krishnamoorthy J, Kamindla R, Wang S. Control of cell fate by the mammalian target of rapamycin (mTOR) under stress depends on eIF2α serine 51 phosphorylation Annals of Oncology. 26: ii25. DOI: 10.1093/Annonc/Mdv094.3 |
0.591 |
|
| 2014 |
Guan BJ, Krokowski D, Majumder M, Schmotzer CL, Kimball SR, Merrick WC, Koromilas AE, Hatzoglou M. Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eif2 Journal of Biological Chemistry. 289: 12593-12611. PMID 24648524 DOI: 10.1074/Jbc.M113.543215 |
0.534 |
|
| 2014 |
Krishnamoorthy J, Rajesh K, Mirzajani F, Kesoglidou P, Papadakis AI, Koromilas AE. Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications. Cell Cycle (Georgetown, Tex.). 13: 801-6. PMID 24401334 DOI: 10.4161/Cc.27726 |
0.573 |
|
| 2014 |
Koromilas A, Tenkerian C, Krishnamoorthy J, Kamindla R, Kazimierczak U, Wang S. 452 eIF2alpha phosphorylation determines the adaptation of tuberous sclerosis complex mutant cells to stress and their response to anti-tumor therapies European Journal of Cancer. 50: 148. DOI: 10.1016/S0959-8049(14)70578-7 |
0.43 |
|
| 2013 |
Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging. 5: 884-901. PMID 24334569 DOI: 10.18632/AGING.100620 |
0.369 |
|
| 2013 |
Koromilas AE, Mounir Z. Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment. Future Oncology (London, England). 9: 1005-15. PMID 23837763 DOI: 10.2217/Fon.13.49 |
0.575 |
|
| 2013 |
Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, ... ... Koromilas AE, et al. A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. The Journal of Biological Chemistry. 288: 17202-13. PMID 23645676 DOI: 10.1074/Jbc.M113.466920 |
0.405 |
|
| 2013 |
Tenkerian C, Mounir Z, Krishnamoorthy J, Koromilas AE. Abstract 3191: The Akt-mTOR axis determines cell fate through the regulation of eIF2α phosphorylation pathway. Cancer Research. 73: 3191-3191. DOI: 10.1158/1538-7445.Am2013-3191 |
0.555 |
|
| 2013 |
Koromilas AE, Kamindla R, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Tenkerian C, Krishnamoorthy J, Hatzoglou M, Haj FG, Ferbeyre G, Kaufman RJ. Abstract C51: eIF2alpha phosphorylation determines cell susceptibility to oxidative stress via Akt activation. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C51 |
0.502 |
|
| 2012 |
Kusio-Kobialka M, Podszywalow-Bartnicka P, Peidis P, Glodkowska-Mrowka E, Wolanin K, Leszak G, Seferynska I, Stoklosa T, Koromilas AE, Piwocka K. The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells. Cell Cycle (Georgetown, Tex.). 11: 4069-78. PMID 23095523 DOI: 10.4161/Cc.22387 |
0.51 |
|
| 2012 |
Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas AE, Haj FG. Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes. Plos One. 7: e34412. PMID 22509299 DOI: 10.1371/Journal.Pone.0034412 |
0.405 |
|
| 2012 |
Daba A, Koromilas AE, Pantopoulos K. Alternative ferritin mRNA translation via internal initiation. Rna (New York, N.Y.). 18: 547-56. PMID 22271759 DOI: 10.1261/Rna.029322.111 |
0.466 |
|
| 2011 |
Mounir Z, Krishnamoorthy JL, Wang S, Papadopoulou B, Campbell S, Muller WJ, Hatzoglou M, Koromilas AE. Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Science Signaling. 4: ra62. PMID 21954288 DOI: 10.1126/Scisignal.2001630 |
0.595 |
|
| 2011 |
Koromilas AE. Negative regulation of mTORC2 by glycogen synthase kinase-3β: an adaptive process to stress with an anticancer therapeutic potential? Future Oncology (London, England). 7: 845-8. PMID 21732756 DOI: 10.2217/Fon.11.59 |
0.535 |
|
| 2011 |
Papadakis AI, Baltzis D, Buensuceso RC, Peidis P, Koromilas AE. Development of transgenic mice expressing a conditionally active form of the eIF2α kinase PKR. Genesis (New York, N.Y. : 2000). 49: 743-9. PMID 21438126 DOI: 10.1002/Dvg.20749 |
0.519 |
|
| 2011 |
Raven JF, Williams V, Wang S, Tremblay ML, Muller WJ, Durbin JE, Koromilas AE. Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (Georgetown, Tex.). 10: 794-804. PMID 21311224 DOI: 10.4161/Cc.10.5.14956 |
0.434 |
|
| 2011 |
Peidis P, Papadakis AI, Muaddi H, Richard S, Koromilas AE. Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death Cell Death and Differentiation. 18: 145-154. PMID 20559319 DOI: 10.1038/Cdd.2010.76 |
0.569 |
|
| 2010 |
Peidis P, Papadakis AI, Rajesh K, Koromilas AE. HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2. Aging. 2: 669-77. PMID 21076179 |
0.38 |
|
| 2010 |
Papadakis AI, Paraskeva E, Peidis P, Muaddi H, Li S, Raptis L, Pantopoulos K, Simos G, Koromilas AE. eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}. Cancer Research. 70: 7820-9. PMID 20924113 DOI: 10.1158/0008-5472.Can-10-0215 |
0.495 |
|
| 2010 |
Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE. Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Molecular Biology of the Cell. 21: 3220-31. PMID 20660158 DOI: 10.1091/Mbc.E10-01-0023 |
0.482 |
|
| 2010 |
Mounir Z, Koromilas AE. Uncovering the PKR pathway's potential for treatment of tumors. Future Oncology (London, England). 6: 643-5. PMID 20465378 DOI: 10.2217/Fon.10.45 |
0.303 |
|
| 2010 |
Wang S, Raven JF, Koromilas AE. STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells. Molecular Cancer Research : McR. 8: 798-805. PMID 20407011 DOI: 10.1158/1541-7786.Mcr-10-0027 |
0.45 |
|
| 2010 |
Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M. eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. The Journal of Biological Chemistry. 285: 17098-111. PMID 20338999 DOI: 10.1074/Jbc.M110.109439 |
0.479 |
|
| 2009 |
Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Science Signaling. 2: ra85. PMID 20029030 DOI: 10.1126/Scisignal.2000389 |
0.562 |
|
| 2009 |
Rahman M, Lem C, Muaddi H, Koromilas AE. PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress. Cell Cycle (Georgetown, Tex.). 8: 3606-7. PMID 19838063 DOI: 10.4161/Cc.8.21.9848 |
0.436 |
|
| 2009 |
Wang S, Koromilas AE. Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells. Cell Cycle (Georgetown, Tex.). 8: 2070-9. PMID 19502801 DOI: 10.4161/Cc.8.13.8891 |
0.456 |
|
| 2008 |
Wang S, Raven JF, Durbin JE, Koromilas AE. Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. Plos One. 3: e3476. PMID 18941537 DOI: 10.1371/Journal.Pone.0003476 |
0.433 |
|
| 2008 |
Miyata M, Raven JF, Baltzis D, Koromilas AE, Sabe H. IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. Cell Cycle (Georgetown, Tex.). 7: 3273-81. PMID 18843202 DOI: 10.4161/Cc.7.20.6883 |
0.433 |
|
| 2008 |
Krishnamoorthy J, Mounir Z, Raven JF, Koromilas AE. The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation. Cell Cycle (Georgetown, Tex.). 7: 2346-51. PMID 18677106 DOI: 10.4161/Cc.6323 |
0.482 |
|
| 2008 |
Raven JF, Koromilas AE. PERK and PKR: old kinases learn new tricks. Cell Cycle (Georgetown, Tex.). 7: 1146-50. PMID 18418049 DOI: 10.4161/Cc.7.9.5811 |
0.567 |
|
| 2008 |
Raven JF, Baltzis D, Wang S, Mounir Z, Papadakis AI, Gao HQ, Koromilas AE. PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation. The Journal of Biological Chemistry. 283: 3097-108. PMID 18063576 DOI: 10.1074/Jbc.M709677200 |
0.473 |
|
| 2008 |
Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE. Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. The Journal of Biological Chemistry. 283: 469-75. PMID 17998206 DOI: 10.1074/Jbc.M704612200 |
0.522 |
|
| 2007 |
Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE. The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. The Journal of Biological Chemistry. 282: 31675-87. PMID 17785458 DOI: 10.1074/Jbc.M704491200 |
0.559 |
|
| 2007 |
Kazemi S, Mounir Z, Baltzis D, Raven JF, Wang S, Krishnamoorthy JL, Pluquet O, Pelletier J, Koromilas AE. A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. Molecular Biology of the Cell. 18: 3635-44. PMID 17596516 DOI: 10.1091/Mbc.E07-01-0053 |
0.553 |
|
| 2007 |
Su Q, Wang S, Baltzis D, Qu LK, Raven JF, Li S, Wong AH, Koromilas AE. Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2. Embo Reports. 8: 265-70. PMID 17290288 DOI: 10.1038/Sj.Embor.7400891 |
0.532 |
|
| 2006 |
Robert F, Kapp LD, Khan SN, Acker MG, Kolitz S, Kazemi S, Kaufman RJ, Merrick WC, Koromilas AE, Lorsch JR, Pelletier J. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Molecular Biology of the Cell. 17: 4632-44. PMID 16928960 DOI: 10.1091/Mbc.E06-06-0478 |
0.357 |
|
| 2006 |
Wang S, Raven JF, Baltzis D, Kazemi S, Brunet DV, Hatzoglou M, Tremblay ML, Koromilas AE. The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. The Journal of Biological Chemistry. 281: 9439-49. PMID 16431927 DOI: 10.1074/Jbc.M504977200 |
0.544 |
|
| 2006 |
Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE. Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 103: 63-8. PMID 16373505 DOI: 10.1073/Pnas.0508207103 |
0.518 |
|
| 2005 |
Pluquet O, Qu LK, Baltzis D, Koromilas AE. Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Molecular and Cellular Biology. 25: 9392-405. PMID 16227590 DOI: 10.1128/Mcb.25.21.9392-9405.2005 |
0.458 |
|
| 2004 |
Baltzis D, Qu LK, Papadopoulou S, Blais JD, Bell JC, Sonenberg N, Koromilas AE. Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. Journal of Virology. 78: 12747-61. PMID 15542627 DOI: 10.1128/Jvi.78.23.12747-12761.2004 |
0.454 |
|
| 2004 |
Huang S, Qu LK, Koromilas AE. Induction of p53-dependent apoptosis in HCT116 tumor cells by RNA viruses and possible implications in virus-mediated oncolysis. Cell Cycle (Georgetown, Tex.). 3: 1043-5. PMID 15254403 DOI: 10.4161/Cc.3.8.1016 |
0.4 |
|
| 2004 |
Stewart D, Kazemi S, Li S, Massimi P, Banks L, Koromilas AE, Matlashewski G. Ubiquitination and proteasome degradation of the E6 proteins of human papillomavirus types 11 and 18. The Journal of General Virology. 85: 1419-26. PMID 15166424 DOI: 10.1099/Vir.0.19679-0 |
0.308 |
|
| 2004 |
Qu L, Koromilas AE. Control of tumor suppressor p53 function by endoplasmic reticulum stress. Cell Cycle (Georgetown, Tex.). 3: 567-70. PMID 15107622 DOI: 10.4161/Cc.3.5.872 |
0.471 |
|
| 2004 |
Kazemi S, Papadopoulou S, Su Q, Koromilas AE. Control of translation initiation factor eIF2 alpha phosphorylation by the human papillomavirus-18E6oncoprotein: Implication in eIF-2 alpha-dependent gene expression and cell death. Molecular and Cellular Biology. 24. PMID 15060162 DOI: 10.1128/Mcb.24.8.3415–3429.2004 |
0.366 |
|
| 2004 |
Kazemi S, Papadopoulou S, Li S, Su Q, Wang S, Yoshimura A, Matlashewski G, Dever TE, Koromilas AE. Control of α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for eIF2α-Dependent Gene Expression and Cell Death Molecular and Cellular Biology. 24: 3415-3429. PMID 15060162 DOI: 10.1128/Mcb.24.8.3415-3429.2004 |
0.502 |
|
| 2004 |
Qu L, Huang S, Baltzis D, Rivas-Estilla AM, Pluquet O, Hatzoglou M, Koumenis C, Taya Y, Yoshimura A, Koromilas AE. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes & Development. 18: 261-77. PMID 14744935 DOI: 10.1101/Gad.1165804 |
0.452 |
|
| 2003 |
Huang S, Qu LK, Cuddihy AR, Ragheb R, Taya Y, Koromilas AE. Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival. Oncogene. 22: 3721-33. PMID 12802279 DOI: 10.1038/Sj.Onc.1206490 |
0.514 |
|
| 2003 |
Yaman I, Fernandez J, Liu H, Caprara M, Komar AA, Koromilas AE, Zhou L, Snider MD, Scheuner D, Kaufman RJ, Hatzoglou M. The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell. 113: 519-31. PMID 12757712 DOI: 10.1016/S0092-8674(03)00345-3 |
0.383 |
|
| 2003 |
Sasaki A, Inagaki-Ohara K, Yoshida T, Yamanaka A, Sasaki M, Yasukawa H, Koromilas AE, Yoshimura A. The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. The Journal of Biological Chemistry. 278: 2432-6. PMID 12459551 DOI: 10.1074/Jbc.C200608200 |
0.498 |
|
| 2002 |
Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Molecular and Cellular Biology. 22: 7405-16. PMID 12370288 DOI: 10.1128/Mcb.22.21.7405-7416.2002 |
0.561 |
|
| 2002 |
Rivas-Estilla AM, Svitkin Y, Lopez Lastra M, Hatzoglou M, Sherker A, Koromilas AE. PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone. Journal of Virology. 76: 10637-53. PMID 12368306 DOI: 10.1128/Jvi.76.21.10637-10653.2002 |
0.41 |
|
| 2002 |
Baltzis D, Li S, Koromilas AE. Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. The Journal of Biological Chemistry. 277: 38364-72. PMID 12161430 DOI: 10.1074/Jbc.M203564200 |
0.458 |
|
| 2002 |
Fernandez J, Bode B, Koromilas A, Diehl JA, Krukovets I, Snider MD, Hatzoglou M. Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. The Journal of Biological Chemistry. 277: 11780-7. PMID 11781318 DOI: 10.1074/jbc.M110778200 |
0.409 |
|
| 2002 |
Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, Hensold J, Hatzoglou M. Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2α phosphorylation and translation of a small upstream open reading frame Journal of Biological Chemistry. 277: 2050-2058. PMID 11684693 DOI: 10.1074/Jbc.M109199200 |
0.421 |
|
| 2001 |
Doualla-Bell F, Koromilas AE. Induction of PG G/H synthase-2 in bovine myometrial cells by interferon-τ requires the activation of the p38 MAPK pathway Endocrinology. 142: 5107-5115. PMID 11713203 DOI: 10.1210/Endo.142.12.8524 |
0.478 |
|
| 2001 |
Ishii T, Kwon H, Hiscott J, Mosialos G, Koromilas AE. Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR. Oncogene. 20: 1900-12. PMID 11313938 DOI: 10.1038/Sj.Onc.1204267 |
0.484 |
|
| 2001 |
Wong AHT, Durbin JE, Li S, Dever TE, Decker T, Koromilas AE. Enhanced Antiviral and Antiproliferative Properties of a STAT1 Mutant Unable to Interact with the Protein Kinase PKR Journal of Biological Chemistry. 276: 13727-13737. PMID 11278865 DOI: 10.1074/Jbc.M011240200 |
0.411 |
|
| 2001 |
Li S, Koromilas AE. Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKR Journal of Biological Chemistry. 276: 13881-13890. PMID 11278390 DOI: 10.1074/Jbc.M008140200 |
0.532 |
|
| 2000 |
Bergeron J, Benlimame N, Zeng-Rong N, Xiao D, Scrivens PJ, Koromilas AE, Alaoui-Jamali MA. Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts Cancer Research. 60: 6800-6804. PMID 11156368 |
0.387 |
|
| 2000 |
Li S, Nagai K, Koromilas AE. A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytes European Journal of Biochemistry. 267: 1598-1606. PMID 10712589 DOI: 10.1046/J.1432-1327.2000.01134.X |
0.494 |
|
| 1999 |
Li S, Labrecque S, Gauzzi MC, Cuddihy AR, Wong AHT, Pellegrini S, Matlashewski GJ, Koromilas AE. The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-α Oncogene. 18: 5727-5737. PMID 10523853 DOI: 10.1038/Sj.Onc.1202960 |
0.304 |
|
| 1999 |
Cuddihy AR, Wong AHT, Nancy Wai Ning T, Suiyang L, Koromilas AE. The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro Oncogene. 18: 2690-2702. PMID 10348343 DOI: 10.1038/Sj.Onc.1202620 |
0.497 |
|
| 1999 |
Tam NWN, Ishii T, Li S, Wong AHT, Cuddihy AR, Koromilas AE. Upregulation of STAT1 protein in cells lacking or expressing mutants of the double-stranded RNA-dependent protein kinase PKR European Journal of Biochemistry. 262: 149-154. PMID 10231376 DOI: 10.1046/J.1432-1327.1999.00360.X |
0.505 |
|
| 1999 |
Cuddihy AR, Li S, Tam NWN, Wong AHT, Taya Y, Abraham N, Bell JC, Koromilas AE. Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53 Molecular and Cellular Biology. 19: 2475-2484. PMID 10082513 DOI: 10.1128/Mcb.19.4.2475 |
0.494 |
|
| 1999 |
Abraham N, Stojdl DF, Duncan PI, Méthot N, Ishii T, Dubé M, Vanderhyden BC, Atkins HL, Gray DA, McBurney MW, Koromilas AE, Brown EG, Sonenberg N, Bell JC. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR Journal of Biological Chemistry. 274: 5953-5962. PMID 10026221 DOI: 10.1074/Jbc.274.9.5953 |
0.477 |
|
| 1997 |
Wong AHT, Ning Tam NW, Yang YL, Cuddihy AR, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas AE. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways Embo Journal. 16: 1291-1304. PMID 9135145 DOI: 10.1093/Emboj/16.6.1291 |
0.509 |
|
| 1997 |
Nagai K, Wong AH, Li S, Tam WN, Cuddihy AR, Sonenberg N, Mathews MB, Hiscott J, Wainberg MA, Koromilas AE. Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR. Journal of Virology. 71: 1718-25. PMID 8995707 DOI: 10.1128/Jvi.71.2.1718-1725.1997 |
0.368 |
|
| 1995 |
Koromilas AE, Cantin C, Craig AW, Jagus R, Hiscott J, Sonenberg N. The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. The Journal of Biological Chemistry. 270: 25426-34. PMID 7592710 DOI: 10.1074/Jbc.270.43.25426 |
0.488 |
|
| 1995 |
Kirchhoff S, Koromilas AE, Schaper F, Grashoff M, Sonenberg N, Hauser H. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR Oncogene. 11: 439-445. PMID 7543195 |
0.382 |
|
| 1995 |
Donzé O, Jagus R, Koromilas AE, Hershey JW, Sonenberg N. Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. The Embo Journal. 14: 3828-3834. DOI: 10.1002/J.1460-2075.1995.Tb00052.X |
0.466 |
|
| 1992 |
Koromilas AE, Roy S, Barber GN, Katze MG, Sonenberg N. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase Science. 257: 1685-1689. PMID 1382315 DOI: 10.1126/Science.1382315 |
0.528 |
|
| 1992 |
Koromilas A, Lazaris-Karatzas A, Sonenberg N. mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. The Embo Journal. 11: 4153-4158. DOI: 10.1002/J.1460-2075.1992.Tb05508.X |
0.391 |
|
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