Xiongwei Zhu, PhD, Case Western Reserve University - Publications

Affiliations: 
Pathology Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=132
Website:
http://www.case.edu/med/pathology/faculty/zhu.html

349 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, Fujioka H, Zhu X. The role of Mfn2 in the structure and function of ER-mitochondrial tethering in vivo. Journal of Cell Science. PMID 34110411 DOI: 10.1242/jcs.253443  1
2021 Everett J, Lermyte F, Brooks J, Tjendana-Tjhin V, Plascencia-Villa G, Hands-Portman I, Donnelly JM, Billimoria K, Perry G, Zhu X, Sadler PJ, O'Connor PB, Collingwood JF, Telling ND. Biogenic metallic elements in the human brain? Science Advances. 7. PMID 34108207 DOI: 10.1126/sciadv.abf6707  1
2021 Bargar C, Wang W, Gunzler SA, LeFevre A, Wang Z, Lerner AJ, Singh N, Tatsuoka C, Appleby B, Zhu X, Xu R, Haroutunian V, Zou WQ, Ma J, Chen SG. Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathologica Communications. 9: 62. PMID 33827706 DOI: 10.1186/s40478-021-01175-w  1
2021 Niu M, Zhao F, Bondelid K, Siedlak SL, Torres S, Fujioka H, Wang W, Liu J, Zhu X. VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease. Aging Cell. e13347. PMID 33745227 DOI: 10.1111/acel.13347  1
2021 Zhao F, Austria Q, Wang W, Zhu X. Mfn2 Overexpression Attenuates MPTP Neurotoxicity In Vivo. International Journal of Molecular Sciences. 22. PMID 33435331 DOI: 10.3390/ijms22020601  1
2020 Wang Z, Becker K, Donadio V, Siedlak S, Yuan J, Rezaee M, Incensi A, Kuzkina A, Orrú CD, Tatsuoka C, Liguori R, Gunzler SA, Caughey B, Jimenez-Capdeville ME, Zhu X, et al. Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease. Jama Neurology. PMID 32986090 DOI: 10.1001/jamaneurol.2020.3311  0.96
2020 Zhu MJ, Shi J, Chen Y, Huang G, Zhu XW, Zhang S, Huang XF, Song GQ, Zhang HT, Ke HM, O'Donnell JM, Wang LQ, Xu Y. Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior. Psychopharmacology. PMID 32926224 DOI: 10.1007/S00213-019-05401-1  0.96
2020 Kelley AR, Colley ME, Dyer S, Bach SBH, Zhu X, Perry G. Ethanol-fixed, paraffin-embedded tissue imaging: implications for Alzheimer's disease research. Journal of the American Society For Mass Spectrometry. PMID 32803969 DOI: 10.1021/Jasms.0C00195  1
2020 Fan X, Sell DR, Hao C, Liu S, Wang B, Wesson DW, Siedlak S, Zhu X, Kavanagh TJ, Harrison FE, Monnier VM. Vitamin C is a source of oxoaldehyde and glycative stress in age-related cataract and neurodegenerative diseases. Aging Cell. PMID 32567221 DOI: 10.1111/Acel.13176  0.68
2020 Wang W, Zhao F, Ma X, Perry G, Zhu X. Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances. Molecular Neurodegeneration. 15: 30. PMID 32471464 DOI: 10.1186/S13024-020-00376-6  1
2020 Qin L, Zhu X, Friedland RP. ApoE and mitochondrial dysfunction. Neurology. PMID 32457209 DOI: 10.1212/Wnl.0000000000009569  0.96
2020 Zhao F, Wang C, Zhu X. Isoform-specific roles of AMPK catalytic α subunits in Alzheimer's disease. The Journal of Clinical Investigation. PMID 32452835 DOI: 10.1172/JCI137908  1
2020 Han S, Nandy P, Austria Q, Siedlak SL, Torres S, Fujioka H, Wang W, Zhu X. Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death. Cells. 9. PMID 31947766 DOI: 10.3390/Cells9010116  1
2019 Li Y, Niu M, Zhao A, Kang W, Chen Z, Luo N, Zhou L, Zhu X, Lu L, Liu J. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease. Journal of Neuroinflammation. 16: 263. PMID 31831012 DOI: 10.1186/s12974-019-1646-6  1
2019 Qin L, Xu Q, Li Z, Chen L, Li Y, Yang N, Liu Z, Guo J, Shen L, Allen EG, Chen C, Ma C, Wu H, Zhu X, Jin P, et al. Ethnicity-specific and overlapping alterations of brain hydroxymethylome in Alzheimer's disease. Human Molecular Genetics. PMID 31814020 DOI: 10.1093/Hmg/Ddz273  1
2019 Liu Y, Ma X, Fujioka H, Liu J, Chen S, Zhu X. DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1. Proceedings of the National Academy of Sciences of the United States of America. PMID 31767755 DOI: 10.1073/Pnas.1906565116  1
2019 Sharoar MG, Hu X, Ma XM, Zhu X, Yan R. Sequential formation of different layers of dystrophic neurites in Alzheimer's brains. Molecular Psychiatry. PMID 30899091 DOI: 10.1038/S41380-019-0396-2  0.84
2019 Jiang S, Shao C, Tang F, Wang W, Zhu X. Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease. Aging Cell. e12912. PMID 30767411 DOI: 10.1111/Acel.12912  1
2018 Su Y, Deng MF, Xiong W, Xie AJ, Guo J, Liang ZH, Hu B, Chen JG, Zhu X, Man HY, Lu Y, Liu D, Tang B, Zhu LQ. MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease. Biological Psychiatry. PMID 30718039 DOI: 10.1016/J.Biopsych.2018.12.008  1
2018 Zhao F, Siedlak SL, Torres SL, Xu Q, Tang B, Zhu X. Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease. Molecular Neurobiology. PMID 30519817 DOI: 10.1007/S12035-018-1431-Z  1
2018 Wang C, Zhao F, Shen K, Wang W, Siedlak SL, Lee HG, Phelix CF, Perry G, Shen L, Tang B, Yan R, Zhu X. The sterol regulatory element-binding protein 2 is likely dysregulated by tau alterations in Alzheimer disease. Brain Pathology (Zurich, Switzerland). PMID 30515907 DOI: 10.1111/Bpa.12691  1
2018 Wang W, Zhu X. HDL mimetic peptides affect apolipoprotein E metabolism: equal supplement or functional enhancer?: An Editorial for 'High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia' on doi:10.1111/jnc.14554. Journal of Neurochemistry. PMID 30474860 DOI: 10.1111/Jnc.14595  1
2018 Guo JF, Zhang L, Li K, Mei JP, Xue J, Chen J, Tang X, Shen L, Jiang H, Chen C, Guo H, Wu XL, Sun SL, Xu Q, Sun QY, ... ... Zhu XW, et al. Coding mutations in contribute to Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348779 DOI: 10.1073/Pnas.1809969115  0.92
2018 Huang X, Xiaokaiti Y, Yang J, Pan J, Li Z, Luria V, Li Y, Song G, Zhu X, Zhang HT, O'Donnell JM, Xu Y. Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior. Neuropharmacology. PMID 30268520 DOI: 10.1016/J.Neuropharm.2018.09.039  0.96
2018 Perry G, Avila J, Zhu X. Birth of JAD: 20 Years Later. Journal of Alzheimer's Disease : Jad. 62: 901. PMID 29562547 DOI: 10.3233/JAD-180120  1
2018 Jiang S, Nandy P, Wang W, Ma X, Hsia J, Wang C, Wang Z, Niu M, Siedlak SL, Torres S, Fujioka H, Xu Y, Lee HG, Perry G, Liu J, ... Zhu X, et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Molecular Neurodegeneration. 13: 5. PMID 29391029 DOI: 10.1186/S13024-018-0238-8  1
2017 Henderson LE, Abdelmegeed MA, Yoo SH, Rhee SG, Zhu X, Smith MA, Nguyen RQ, Perry G, Song BJ. Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer's Disease. The Open Neurology Journal. 11: 48-58. PMID 29290835 DOI: 10.2174/1874205X01711010048  1
2017 He L, Jiang Y, Liu K, Gómez-Murcia V, Ma X, Torrecillas A, Wang L, Chen Q, Zhu X, Lesnefsky E, Gomez-Fernandez JC, Xu B, Zhang S. Insights into the impact of membrane-anchoring moiety on the biological activities of bivalent compounds as potential neuroprotectants for Alzheimer's disease. Journal of Medicinal Chemistry. PMID 29271648 DOI: 10.1021/acs.jmedchem.7b01284  1
2017 Wang W, Yin J, Ma X, Zhao F, Siedlak SL, Wang Z, Fujioka H, Xu Y, Perry G, Zhu X. Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model. Human Molecular Genetics. PMID 28973308 DOI: 10.1093/Hmg/Ddx299  1
2017 Liu Y, Zhu X. Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases. Translational Neurodegeneration. 6: 21. PMID 28852477 DOI: 10.1186/s40035-017-0092-6  1
2017 Nunomura A, Lee HG, Zhu X, Perry G. Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders. Biochemical Society Transactions. PMID 28778984 DOI: 10.1042/BST20160433  1
2017 Zhou L, Wang W, Hoppel C, Liu J, Zhu X. Parkinson's Disease-Associated Pathogenic VPS35 Mutation Causes Complex I Deficits. Biochimica Et Biophysica Acta. PMID 28765075 DOI: 10.1016/J.Bbadis.2017.07.032  1
2017 Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 28255908 DOI: 10.1007/s12035-017-0467-9  1
2017 Zhao F, Wang W, Wang C, Siedlak SL, Fujioka H, Tang B, Zhu X. Mfn2 Protects Dopaminergic Neurons Exposed to Paraquat Both in vitro and in vivo: Implications for Idiopathic Parkinson's Disease. Biochimica Et Biophysica Acta. PMID 28215578 DOI: 10.1016/J.Bbadis.2017.02.016  1
2017 Niu Y, Zhang W, Chen H, Mao S, Yue Y, Zhang H, Li L, Sun P, Wang J, Zhu X. Cross-cultural adaptation of the Kidney Transplant Questionnaire for Chinese adult kidney allograft recipients. Journal of Evaluation in Clinical Practice. PMID 28116832 DOI: 10.1111/jep.12695  0.92
2016 Wang W, Ma X, Zhou L, Liu J, Zhu X. A Conserved Retromer Sorting Motif is Essential for Mitochondrial DLP1 Recycling by VPS35 in Parkinson's Disease Model. Human Molecular Genetics. PMID 28040727 DOI: 10.1093/Hmg/Ddw430  1
2016 Nunomura A, Zhu X, Perry G. Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration. Journal of Alzheimer's Disease : Jad. PMID 27802241 DOI: 10.3233/JAD-160878  1
2016 Gore E, Appleby BS, Cohen ML, DeBrosse SD, Leverenz JB, Miller BL, Siedlak SL, Zhu X, Lerner AJ. Clinical and imaging characteristics of late onset mitochondrial membrane protein-associated neurodegeneration (MPAN). Neurocase. 1-8. PMID 27801611 DOI: 10.1080/13554794.2016.1247458  1
2016 Wei Y, Yang N, Xu Q, Sun Q, Guo J, Li K, Liu Z, Yan X, Zhu X, Tang B. The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population. Journal of the Neurological Sciences. 367: 11-14. PMID 27423554 DOI: 10.1016/j.jns.2016.05.037  1
2016 Yang N, Wei Y, Wang T, Guo J, Sun Q, Hu Y, Yan X, Zhu X, Tang B, Xu Q. Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra. Scientific Reports. 6: 28933. PMID 27380887 DOI: 10.1038/srep28933  1
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Correction: Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0157209. PMID 27258001 DOI: 10.1371/Journal.Pone.0157209  1
2016 Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ. Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's disease. Antioxidants & Redox Signaling. PMID 27224303 DOI: 10.1089/Ars.2015.6598  1
2016 Plascencia-Villa G, Ponce A, Collingwood JF, Arellano-Jiménez MJ, Zhu X, Rogers JT, Betancourt I, José-Yacamán M, Perry G. High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Scientific Reports. 6: 24873. PMID 27121137 DOI: 10.1038/Srep24873  1
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0151615. PMID 26982086 DOI: 10.1371/Journal.Pone.0151615  1
2016 Johnson WM, Golczak M, Choe K, Currran PL, Gorelenkova Miller O, Yao C, Wang W, Lin J, Milkovic NM, Ray A, Ravindranath V, Zhu X, Wilson MA, Wilson-Delfosse AL, Chen SG, et al. Regulation of DJ-1 by glutaredoxin 1 in vivo - implications for Parkinson's disease. Biochemistry. PMID 26894491 DOI: 10.1021/Acs.Biochem.5B01132  1
2016 Wang C, Zhang F, Jiang S, Siedlak SL, Shen L, Perry G, Wang X, Tang B, Zhu X. Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease. Scientific Reports. 6: 20352. PMID 26837465 DOI: 10.1038/Srep20352  1
2015 Sharoar MG, Shi Q, Ge Y, He W, Hu X, Perry G, Zhu X, Yan R. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Molecular Psychiatry. PMID 26619807 DOI: 10.1038/Mp.2015.181  0.88
2015 Wang W, Wang X, Fujioka H, Hoppel C, Whone AL, Caldwell MA, Cullen PJ, Liu J, Zhu X. Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nature Medicine. PMID 26618722 DOI: 10.1038/Nm.3983  1
2015 Blair JA, Palm R, Chang J, McGee H, Zhu X, Wang X, Smith GC. Luteinizing hormone downregulation but not estrogen replacement improves ovariectomy-associated cognition and spine density loss independently of treatment onset timing. Hormones and Behavior. PMID 26497249 DOI: 10.1016/J.Yhbeh.2015.10.013  1
2015 Zhang B, Cowden D, Zhang F, Yuan J, Siedlak S, Abouelsaad M, Zeng L, Zhou X, O'Toole J, Das AS, Kofskey D, Warren M, Bian Z, Cui Y, Tan T, ... ... Zhu X, et al. Correction: Prion Protein Protects against Renal Ischemia/Reperfusion Injury. Plos One. 10: e0141025. PMID 26469069 DOI: 10.1371/Journal.Pone.0141025  1
2015 Gustafson DR, Clare Morris M, Scarmeas N, Shah RC, Sijben J, Yaffe K, Zhu X. New Perspectives on Alzheimer's Disease and Nutrition. Journal of Alzheimer's Disease : Jad. 46: 1111-27. PMID 26402637 DOI: 10.3233/JAD-150084  1
2015 Zhang B, Cowden D, Zhang F, Yuan J, Siedlak S, Abouelsaad M, Zeng L, Zhou X, O'Toole J, Das AS, Kofskey D, Warren M, Bian Z, Cui Y, Tan T, ... ... Zhu X, et al. Prion Protein Protects against Renal Ischemia/Reperfusion Injury. Plos One. 10: e0136923. PMID 26327228 DOI: 10.1371/Journal.Pone.0136923  1
2015 Jiang Z, Wang W, Perry G, Zhu X, Wang X. Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis. Translational Neurodegeneration. 4: 14. PMID 26225210 DOI: 10.1186/S40035-015-0037-X  1
2015 Zhang F, Wang W, Siedlak SL, Liu Y, Liu J, Jiang K, Perry G, Zhu X, Wang X. Miro1 deficiency in amyotrophic lateral sclerosis. Frontiers in Aging Neuroscience. 7: 100. PMID 26074815 DOI: 10.3389/Fnagi.2015.00100  1
2015 Zhang F, Su B, Wang C, Siedlak SL, Mondragon-Rodriguez S, Lee HG, Wang X, Perry G, Zhu X. Posttranslational modifications of α-tubulin in alzheimer disease. Translational Neurodegeneration. 4: 9. PMID 26029362 DOI: 10.1186/S40035-015-0030-4  1
2015 Gerenu G, Liu K, Chojnacki JE, Saathoff JM, Martínez-Martín P, Perry G, Zhu X, Lee HG, Zhang S. Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model. Acs Chemical Neuroscience. PMID 25893520 DOI: 10.1021/acschemneuro.5b00082  1
2015 Johnson WM, Yao C, Siedlak SL, Wang W, Zhu X, Caldwell GA, Wilson-Delfosse AL, Mieyal JJ, Chen SG. Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease. Human Molecular Genetics. 24: 1322-35. PMID 25355420 DOI: 10.1093/Hmg/Ddu542  1
2014 Lin L, Lee JH, Bongmba OY, Ma X, Zhu X, Sheikh-Hamad D, Sun Y. The suppression of ghrelin signaling mitigates age‐associated thermogenic impairment. Aging. 6: 1019-32. PMID 25543537  1
2014 Hwang RD, Wiemerslage L, LaBreck CJ, Khan M, Kannan K, Wang X, Zhu X, Lee D, Fridell YW. The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease. Neurobiology of Disease. 69: 180-91. PMID 24965893 DOI: 10.1016/J.Nbd.2014.05.032  1
2014 Li L, Wang W, Welford S, Zhang T, Wang X, Zhu X. Ionizing radiation causes increased tau phosphorylation in primary neurons. Journal of Neurochemistry. 131: 86-93. PMID 24861936 DOI: 10.1111/Jnc.12769  1
2014 Bonda DJ, Wang X, Lee HG, Smith MA, Perry G, Zhu X. Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass. Neuroscience Bulletin. 30: 243-52. PMID 24733654 DOI: 10.1007/S12264-013-1424-X  1
2014 Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. Journal of Neurochemistry. 130: 115-25. PMID 24601954 DOI: 10.1111/jnc.12706  1
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  1
2014 Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochimica Et Biophysica Acta. 1842: 1240-7. PMID 24189435 DOI: 10.1016/J.Bbadis.2013.10.015  1
2014 Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. Journal of Neurochemistry. 128: 162-72. PMID 23895348 DOI: 10.1111/Jnc.12380  1
2014 Castellani RJ, Zhu X, Perry G, Moreira PI. Alzheimer's Disease: An Overview Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.04491-3  1
2013 Fujioka H, Phelix CF, Friedland RP, Zhu X, Perry EA, Castellani RJ, Perry G. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease. Journal of Health Care For the Poor and Underserved. 24: 70-8. PMID 24241262 DOI: 10.1353/Hpu.2014.0009  1
2013 Williams WM, Torres S, Siedlak SL, Castellani RJ, Perry G, Smith MA, Zhu X. Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain. Journal of Neuroinflammation. 10: 127. PMID 24139179 DOI: 10.1186/1742-2094-10-127  1
2013 Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Acevedo-Aquino MC, Williams S. Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease. Oxidative Medicine and Cellular Longevity. 2013: 940603. PMID 23936615 DOI: 10.1155/2013/940603  1
2013 Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radical Research. 47: 507-10. PMID 23566300 DOI: 10.3109/10715762.2013.794265  1
2013 Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Preface. Alzheimer's disease: advances for a new century. Journal of Alzheimer's Disease : Jad. 33: S1. PMID 23397602  1
2013 Haldar S, Beveridge 'J, Wong J, Singh A, Galimberti D, Borroni B, Zhu X, Blevins J, Greenlee J, Perry G, Mukhopadhyay CK, Schmotzer C, Singh N. A low-molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxidants & Redox Signaling. 19: 1662-75. PMID 23379482 DOI: 10.1089/Ars.2012.5032  1
2013 Santos RX, Correia SC, Zhu X, Smith MA, Moreira PI, Castellani RJ, Nunomura A, Perry G. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxidants & Redox Signaling. 18: 2444-57. PMID 23216311 DOI: 10.1089/Ars.2012.5039  1
2013 Yan MH, Wang X, Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radical Biology & Medicine. 62: 90-101. PMID 23200807 DOI: 10.1016/J.Freeradbiomed.2012.11.014  1
2013 Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics. 22: 328-44. PMID 23065705 DOI: 10.1093/Hmg/Dds431  1
2013 Zhu X, Perry G, Smith MA, Wang X. Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: S253-62. PMID 22531428 DOI: 10.3233/Jad-2012-129005  1
2013 Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Alzheimer's disease: Advances for a new century Journal of Alzheimer's Disease. 33: S1. DOI: 10.3233/JAD-2012-129045  1
2012 Rodrigues R, Smith MA, Wang X, Perry G, Lee HG, Zhu X, Petersen RB. Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress. Future Neurology. 7: 287-305. PMID 23086377 DOI: 10.2217/Fnl.12.27  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Zhu XF, ... ... Zhu X, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  1
2012 Liu G, Men P, Zhu X, Perry G. Iron chelation and nanoparticle target delivery in the development of new multifunctional disease-modifying drugs for Alzheimer's disease. Therapeutic Delivery. 3: 571-4. PMID 22834400 DOI: 10.4155/tde.12.32  1
2012 Fawver JN, Duong KT, Wise-Scira O, Petrofes Chapa R, Schall HE, Coskuner O, Zhu X, Colom LV, Murray IV. Probing and trapping a sensitive conformation: amyloid-β fibrils, oligomers, and dimers. Journal of Alzheimer's Disease : Jad. 32: 197-215. PMID 22785403 DOI: 10.3233/Jad-2012-120880  1
2012 Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Williams S. Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target? International Journal of Alzheimer's Disease. 2012: 276803. PMID 22779025 DOI: 10.1155/2012/276803  1
2012 Liu K, Guo TL, Chojnacki J, Lee HG, Wang X, Siedlak SL, Rao W, Zhu X, Zhang S. Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease. Acs Chemical Neuroscience. 3: 141-146. PMID 22685625 DOI: 10.1021/Cn200122J  1
2012 Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotoxicity Research. 22: 231-48. PMID 22669748 DOI: 10.1007/s12640-012-9331-x  1
2012 Mondragón-Rodríguez S, Perry G, Zhu X, Boehm J. Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy. International Journal of Alzheimer's Disease. 2012: 630182. PMID 22482074 DOI: 10.1155/2012/630182  1
2012 Castellani RJ, Moreira PI, Perry G, Zhu X. The role of iron as a mediator of oxidative stress in Alzheimer disease. Biofactors (Oxford, England). 38: 133-8. PMID 22447715 DOI: 10.1002/biof.1010  1
2012 Wang X, Petrie TG, Liu Y, Liu J, Fujioka H, Zhu X. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. Journal of Neurochemistry. 121: 830-9. PMID 22428580 DOI: 10.1111/J.1471-4159.2012.07734.X  1
2012 Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA. Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases. Advances in Experimental Medicine and Biology. 724: 205-21. PMID 22411245 DOI: 10.1007/978-1-4614-0653-2_16  1
2012 Fawver JN, Schall HE, Petrofes Chapa RD, Zhu X, Murray IV. Amyloid-β metabolite sensing: biochemical linking of glycation modification and misfolding. Journal of Alzheimer's Disease : Jad. 30: 63-73. PMID 22406446 DOI: 10.3233/Jad-2012-112114  1
2012 Reed-Cossairt A, Zhu X, Lee HG, Reed C, Perry G, Petersen RB. Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Current Gerontology and Geriatrics Research. 2012: 929734. PMID 22400025 DOI: 10.1155/2012/929734  1
2012 Wang X, Snape M, Klann E, Stone JG, Singh A, Petersen RB, Castellani RJ, Casadesus G, Smith MA, Zhu X. Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. Journal of Neurochemistry. 121: 672-9. PMID 22393900 DOI: 10.1111/J.1471-4159.2012.07722.X  1
2012 Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 39: 4. PMID 22384486 DOI: 10.1017/S0317167100012609  1
2012 Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. Journal of Neuropathology and Experimental Neurology. 71: 233-41. PMID 22318126 DOI: 10.1097/NEN.0b013e318248e614  1
2012 Lee HP, Pancholi N, Esposito L, Previll LA, Wang X, Zhu X, Smith MA, Lee HG. Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. Plos One. 7: e28033. PMID 22276093 DOI: 10.1371/Journal.Pone.0028033  1
2012 Zhu X, Castellani RJ, Ziats NP, Petersen RB, Gon Lee H, Perry G. Mark A. Smith: neurocytochemistry innovator. Journal of Neurochemistry. 120: 1139-40. PMID 22268813 DOI: 10.1111/J.1471-4159.2012.07656.X  1
2012 Bonda DJ, Liu G, Men P, Perry G, Smith MA, Zhu X. Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming! Cns & Neurological Disorders Drug Targets. 11: 81-5. PMID 22229318 DOI: 10.2174/187152712799960709  1
2012 Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Human Molecular Genetics. 21: 1931-44. PMID 22228096 DOI: 10.1093/Hmg/Dds003  1
2012 Santos RX, Correia SC, Zhu X, Lee HG, Petersen RB, Nunomura A, Smith MA, Perry G, Moreira PI. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radical Research. 46: 565-76. PMID 22149654 DOI: 10.3109/10715762.2011.648188  1
2012 Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radical Biology & Medicine. 52: 699-704. PMID 22137893 DOI: 10.1016/J.Freeradbiomed.2011.11.004  1
2012 Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG. Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human Molecular Genetics. 21: 1138-44. PMID 22100763 DOI: 10.1093/Hmg/Ddr542  1
2012 Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. Journal of Neurochemistry. 120: 419-29. PMID 22077634 DOI: 10.1111/J.1471-4159.2011.07581.X  1
2012 Perry G, Zhu X, Smith MA, Sorensen A, Avila J. Preface: Alzheimer's disease: Advances for a new century Advances in Alzheimer's Disease. 3: 1. DOI: 10.3233/978-1-61499-154-0-1  1
2012 Lee HG, Perry G, Zhu X. Mark Smith: Pioneer of Alzheimer disease research Neurotoxicity Research. 22: 181. DOI: 10.1007/s12640-012-9341-8  1
2011 Ziats NP, Petersen RB, Lee HG, Castellani RJ, Perry G, Zhu X. Mark A. Smith, 1965-2010: consummate student of pathogenesis. International Journal of Clinical and Experimental Pathology. 4: 731-2. PMID 22076176  1
2011 Lee HP, Kudo W, Zhu X, Smith MA, Lee HG. Early induction of c-Myc is associated with neuronal cell death. Neuroscience Letters. 505: 124-7. PMID 22005580 DOI: 10.1016/J.Neulet.2011.10.004  1
2011 Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 1777-86. PMID 21968813 DOI: 10.1038/Labinvest.2011.149  1
2011 Castellani RJ, Petersen RB, Lee HG, Zhu X, Perry G. Mark A. Smith: the scientist, the man. International Journal of Experimental Pathology. 92: 297-8. PMID 21917030 DOI: 10.1111/J.1365-2613.2011.00785.X  1
2011 Liu Q, Xie F, Alvarado-Diaz A, Smith MA, Moreira PI, Zhu X, Perry G. Neurofilamentopathy in neurodegenerative diseases. The Open Neurology Journal. 5: 58-62. PMID 21915226 DOI: 10.2174/1874205X01105010058  1
2011 Bonda DJ, Smith MA, Perry G, Lee HG, Wang X, Zhu X. The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention. Current Pharmaceutical Design. 17: 3374-80. PMID 21902671 DOI: 10.2174/138161211798072562  1
2011 Stone JG, Casadesus G, Gustaw-Rothenberg K, Siedlak SL, Wang X, Zhu X, Perry G, Castellani RJ, Smith MA. Frontiers in Alzheimer's disease therapeutics. Therapeutic Advances in Chronic Disease. 2: 9-23. PMID 21743833 DOI: 10.1177/2040622310382817  1
2011 Wolfram JA, Liner A, Richardson SL, Zhu X, Smith MA, Hoit BD, Lee HG. The role of E2F1 in the development of hypertrophic cardiomyopathy. International Journal of Clinical and Experimental Pathology. 4: 521-5. PMID 21738823  1
2011 Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. Journal of Neuropathology and Experimental Neurology. 70: 578-87. PMID 21666500 DOI: 10.1097/Nen.0B013E3182204414  1
2011 Moh C, Kubiak JZ, Bajic VP, Zhu X, Smith MA, Lee HG. Cell cycle deregulation in the neurons of Alzheimer's disease. Results and Problems in Cell Differentiation. 53: 565-76. PMID 21630160 DOI: 10.1007/978-3-642-19065-0_23  1
2011 Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell. 10: 807-23. PMID 21615675 DOI: 10.1111/J.1474-9726.2011.00721.X  1
2011 Bonda DJ, Castellani RJ, Zhu X, Nunomura A, Lee HG, Perry G, Smith MA. A novel perspective on tau in Alzheimer's disease. Current Alzheimer Research. 8: 639-42. PMID 21605042 DOI: 10.2174/156720511796717131  1
2011 Bajić VP, Su B, Lee HG, Kudo W, Siedlak SL, Zivković L, Spremo-Potparević B, Djelic N, Milicevic Z, Singh AK, Fahmy LM, Wang X, Smith MA, Zhu X. Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease. Cellular & Molecular Biology Letters. 16: 359-72. PMID 21461981 DOI: 10.2478/S11658-011-0011-2  1
2011 Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, et al. Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of Biological Chemistry. 286: 15095-105. PMID 21393248 DOI: 10.1074/Jbc.M110.199356  1
2011 Perry G, Zhu X. Mark Anthony Smith (1965-2010): Visionary, Alzheimer researcher, and editor-in-chief of the Journal of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 24: 1-2. PMID 21383496 DOI: 10.3233/JAD-2011-111437  1
2011 Bonda DJ, Lee HG, Camins A, Pallàs M, Casadesus G, Smith MA, Zhu X. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. The Lancet. Neurology. 10: 275-9. PMID 21349442 DOI: 10.1016/S1474-4422(11)70013-8  1
2011 Bonda DJ, Lee HG, Blair JA, Zhu X, Perry G, Smith MA. Role of metal dyshomeostasis in Alzheimer's disease. Metallomics : Integrated Biometal Science. 3: 267-70. PMID 21298161 DOI: 10.1039/c0mt00074d  1
2011 Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA. Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease? Ageing Research Reviews. 10: 264-73. PMID 21262392 DOI: 10.1016/J.Arr.2011.01.001  1
2011 Castellani RJ, Nugent SL, Morrison AL, Zhu X, Lee HG, Harris PL, Bajić V, Sharma HS, Chen SG, Oettgen P, Perry G, Smith MA. CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 23-6. PMID 20972807 DOI: 10.1007/S00702-010-0485-5  1
2011 Phelix CF, LeBaron RG, Roberson DJ, Villanueva RE, Villareal G, Rahimi OB, Siedlak S, Zhu X, Perry G. Transcriptome-To-Metabolome™ Biosimulation Reveals Human Hippocampal Hypometabolism with Age and Alzheimer’s Disease International Journal of Knowledge Discovery in Bioinformatics. 2: 1-18. DOI: 10.4018/Jkdb.2011040101  1
2011 Phelix CF, LeBaron RG, Roberson DJ, Villanueva RE, Villareal G, Rahimi OB, Siedlak S, Zhu X, Perry G. Transcriptome-To-Metabolome™ Biosimulation Reveals Human Hippocampal Hypometabolism with Age and Alzheimer’s Disease International Journal of Knowledge Discovery in Bioinformatics. 2: 1-18. DOI: 10.4018/ijkdb.2011040101  1
2011 Castellani RJ, Lee HG, Petersen RB, Zhu X, Perry G. Pathological phenotype in familial neurodegenerative disease: Implications for families and therapeutic constructs Therapy. 8: 475-479. DOI: 10.2217/Thy.11.62  1
2011 Castellani RJ, Zhu X, Perry G. Alzheimer's disease therapy: A moving target Therapy. 8: 457-458. DOI: 10.2217/thy.11.56  1
2011 Rothenberg KG, Siedlak SL, Lee HG, Zhu X, Perry G, Smith MA. Neurodegenerative processes in Alzheimer's disease: An overview of pathogenesis with strategic biomarker potential Future Neurology. 6: 173-185. DOI: 10.2217/Fnl.10.81  1
2011 Carvalho C, Correia SC, Santos RX, Cardoso S, Moreira PI, Zhu X, Smith MA, Perry G. Association of mitochondrial signaling in Alzheimer's disease and hypoxia Molecular Aspects of Neurodegeneration and Neuroprotection. 50-61. DOI: 10.2174/978160805092511101010050  1
2011 Phelix CF, LeBaron RG, Roberson DJ, Villanueva RE, Villareal G, Rahimi OB, Siedlak S, Zhu X, Perry G. In vivo and in silico evidence: Hippocampal cholesterol metabolism decreases with aging and increases with Alzheimers disease modeling brain aging and disease Proceedings - Ieee International Conference On Data Mining, Icdm. 1064-1070. DOI: 10.1109/ICDMW.2011.98  1
2010 Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Casadesus G, Smith MA, Lee HG, Perry G. Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. International Journal of Biomedical Science : Ijbs. 6: 225-227. PMID 21765811  1
2010 Dwyer BE, Zacharski LR, Balestra DJ, Lerner AJ, Perry G, Zhu X, Smith MA. Potential role of iron in a Mediterranean-style diet. Archives of Neurology. 67: 1286-7; author reply. PMID 20937965 DOI: 10.1001/archneurol.2010.245  1
2010 Correia SC, Carvalho C, Cardoso S, Santos RX, Santos MS, Oliveira CR, Perry G, Zhu X, Smith MA, Moreira PI. Mitochondrial preconditioning: a potential neuroprotective strategy. Frontiers in Aging Neuroscience. 2. PMID 20838473 DOI: 10.3389/Fnagi.2010.00138  1
2010 Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Report : Communications in Free Radical Research. 15: 161-8. PMID 20663292 DOI: 10.1179/174329210X12650506623645  1
2010 Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI, Zhu X. Alzheimer's disease: diverse aspects of mitochondrial malfunctioning. International Journal of Clinical and Experimental Pathology. 3: 570-81. PMID 20661404  1
2010 Moreira PI, Santos RX, Zhu X, Lee HG, Smith MA, Casadesus G, Perry G. Autophagy in Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1209-18. PMID 20586699 DOI: 10.1586/Ern.10.84  1
2010 Lee HP, Zhu X, Casadesus G, Castellani RJ, Nunomura A, Smith MA, Lee HG, Perry G. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1201-8. PMID 20586698 DOI: 10.1586/ern.10.74  1
2010 Bonda DJ, Lee HP, Kudo W, Zhu X, Smith MA, Lee HG. Pathological implications of cell cycle re-entry in Alzheimer disease. Expert Reviews in Molecular Medicine. 12: e19. PMID 20584423 DOI: 10.1017/S146239941000150X  1
2010 Galindo MF, Ikuta I, Zhu X, Casadesus G, Jordán J. Mitochondrial biology in Alzheimer's disease pathogenesis. Journal of Neurochemistry. 114: 933-45. PMID 20492350 DOI: 10.1111/j.1471-4159.2010.06814.x  1
2010 Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA. Mitochondria: the missing link between preconditioning and neuroprotection. Journal of Alzheimer's Disease : Jad. 20: S475-85. PMID 20463394 DOI: 10.3233/Jad-2010-100669  1
2010 Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI, Zhu X. A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 20: S401-12. PMID 20463393 DOI: 10.3233/Jad-2010-100666  1
2010 Mondragón-Rodríguez S, Basurto-Islas G, Lee HG, Perry G, Zhu X, Castellani RJ, Smith MA. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Review of Neurotherapeutics. 10: 683-91. PMID 20420489 DOI: 10.1586/Ern.10.27  1
2010 Bonda DJ, Wang X, Perry G, Nunomura A, Tabaton M, Zhu X, Smith MA. Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology. 59: 290-4. PMID 20394761 DOI: 10.1016/J.Neuropharm.2010.04.005  1
2010 Gustaw-Rothenberg K, Lerner A, Bonda DJ, Lee HG, Zhu X, Perry G, Smith MA. Biomarkers in Alzheimer's disease: past, present and future. Biomarkers in Medicine. 4: 15-26. PMID 20387301 DOI: 10.2217/bmm.09.86  1
2010 Yao C, El Khoury R, Wang W, Byrd TA, Pehek EA, Thacker C, Zhu X, Smith MA, Wilson-Delfosse AL, Chen SG. LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. Neurobiology of Disease. 40: 73-81. PMID 20382224 DOI: 10.1016/J.Nbd.2010.04.002  1
2010 Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 574-9. PMID 20374499 DOI: 10.1111/J.1440-1789.2010.01107.X  1
2010 Lee HP, Zhu X, Liu G, Chen SG, Perry G, Smith MA, Lee HG. Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship. Cell Research. 20: 397-9. PMID 20357807 DOI: 10.1038/Cr.2010.39  1
2010 Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M. eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. The Journal of Biological Chemistry. 285: 17098-111. PMID 20338999 DOI: 10.1074/Jbc.M110.109439  1
2010 Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1155-67. PMID 20308782 DOI: 10.3233/Jad-2010-1308  1
2010 Bonda DJ, Wang X, Perry G, Smith MA, Zhu X. Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs & Aging. 27: 181-92. PMID 20210366 DOI: 10.2165/11532140-000000000-00000  1
2010 Bonda DJ, Lee HP, Lee HG, Friedlich AL, Perry G, Zhu X, Smith MA. Novel therapeutics for Alzheimer's disease: an update. Current Opinion in Drug Discovery & Development. 13: 235-46. PMID 20205057  1
2010 Wang X, Perry G, Smith MA, Zhu X. Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons. Neuro-Degenerative Diseases. 7: 56-9. PMID 20160460 DOI: 10.1159/000283484  1
2010 Su B, Wang X, Bonda D, Perry G, Smith M, Zhu X. Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Molecular Neurobiology. 41: 87-96. PMID 20101529 DOI: 10.1007/S12035-009-8095-7  1
2010 Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, Nakamura M, Nunomura A, Perry G. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. Journal of Alzheimer's Disease : Jad. 19: 363-72. PMID 20061651 DOI: 10.3233/Jad-2010-1239  1
2010 Bonda DJ, Bajić VP, Spremo-Potparevic B, Casadesus G, Zhu X, Smith MA, Lee HG. Review: cell cycle aberrations and neurodegeneration. Neuropathology and Applied Neurobiology. 36: 157-63. PMID 20059701 DOI: 10.1111/J.1365-2990.2010.01064.X  1
2010 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/J.Nbd.2009.12.012  1
2010 Tabaton M, Perry G, Zhu X, Lee HG, Casadesus G, Smith MA. Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease. The American Journal of Pathology. 176: 540-1. PMID 20019185 DOI: 10.2353/ajpath.2010.090856  1
2010 Moreira PI, Sayre LM, Zhu X, Nunomura A, Smith MA, Perry G. Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods in Molecular Biology (Clifton, N.J.). 610: 419-34. PMID 20013193 DOI: 10.1007/978-1-60327-029-8_25  1
2010 Zhu X. Mitochondrial dysfunction: mitochondrial diseases and pathways with a focus on neurodegeneration. Preface. Biochimica Et Biophysica Acta. 1802: 1. PMID 19969251 DOI: 10.1016/j.bbadis.2009.11.004  1
2010 Bryan KJ, Mudd JC, Richardson SL, Chang J, Lee HG, Zhu X, Smith MA, Casadesus G. Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits. Journal of Neurochemistry. 112: 870-81. PMID 19943850 DOI: 10.1111/J.1471-4159.2009.06502.X  1
2010 Su B, Wang X, Lee HG, Tabaton M, Perry G, Smith MA, Zhu X. Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells. Neuroscience Letters. 468: 267-71. PMID 19914335 DOI: 10.1016/J.Neulet.2009.11.010  1
2010 Moreira PI, Carvalho C, Zhu X, Smith MA, Perry G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochimica Et Biophysica Acta. 1802: 2-10. PMID 19853658 DOI: 10.1016/j.bbadis.2009.10.006  1
2010 Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA. Mitochondria: a therapeutic target in neurodegeneration. Biochimica Et Biophysica Acta. 1802: 212-20. PMID 19853657 DOI: 10.1016/J.Bbadis.2009.10.007  1
2010 Su B, Wang X, Zheng L, Perry G, Smith MA, Zhu X. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochimica Et Biophysica Acta. 1802: 135-42. PMID 19799998 DOI: 10.1016/J.Bbadis.2009.09.013  1
2010 Tabaton M, Zhu X, Perry G, Smith MA, Giliberto L. Signaling effect of amyloid-beta(42) on the processing of AbetaPP. Experimental Neurology. 221: 18-25. PMID 19747481 DOI: 10.1016/j.expneurol.2009.09.002  1
2010 Zhu X, Beal MF, Wang X, Perry G, Smith MA. Preface: Mitochondria and neurodegenerative diseases Journal of Alzheimer's Disease. 20: S253. DOI: 10.3233/Jad-2010-1424  1
2010 Rodrigues R, Bonda DJ, Perry G, Castellani RJ, Casadesus G, Lee HG, Lee HP, Wang X, Zhu X, Petersen RB, Smith MA. Oxidative stress and neurodegeneration: An inevitable consequence of aging? Implications for therapy Brain Protection in Schizophrenia, Mood and Cognitive Disorders. 305-323. DOI: 10.1007/978-90-481-8553-5_10  1
2009 Cardoso S, Santos R, Correia S, Carvalho C, Zhu X, Lee HG, Casadesus G, Smith MA, Perry G, Moreira PI. Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets. Pharmaceuticals (Basel, Switzerland). 2: 250-286. PMID 27713238 DOI: 10.3390/Ph2030250  1
2009 Rolston RK, Perry G, Zhu X, Castellani RJ, Dwyer BE, Lee HG, Petersen RB, Smith MA. Iron: A Pathological Mediator of Alzheimer Disease? Agro Food Industry Hi-Tech. 19: 33-36. PMID 21544251  1
2009 Friedlich AL, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA. Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Medicine Reports. 1. PMID 20948726 DOI: 10.3410/M1-54  1
2009 Bonda DJ, Wang X, Gustaw-Rothenberg KA, Perry G, Smith MA, Zhu X. Mitochondrial Drugs for Alzheimer Disease. Pharmaceuticals (Basel, Switzerland). 2: 287-298. PMID 20657666 DOI: 10.3390/Ph2030287  1
2009 Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 20009219 DOI: 10.3233/JAD-2009-1308  1
2009 Perry G, Moreira PI, Siedlak SL, Nunomura A, Zhu X, Smith MA. Natural oxidant balance in Parkinson disease. Archives of Neurology. 66: 1445. PMID 20008647 DOI: 10.1001/Archneurol.2009.261  1
2009 Lee HP, Casadesus G, Zhu X, Lee HG, Perry G, Smith MA, Gustaw-Rothenberg K, Lerner A. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Review of Neurotherapeutics. 9: 1615-21. PMID 19903021 DOI: 10.1586/ern.09.86  1
2009 Carvalho C, Correia SC, Santos RX, Cardoso S, Moreira PI, Clark TA, Zhu X, Smith MA, Perry G. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia. Journal of Bioenergetics and Biomembranes. 41: 433-40. PMID 19830532 DOI: 10.1007/S10863-009-9247-1  1
2009 Lee HG, Chen Q, Wolfram JA, Richardson SL, Liner A, Siedlak SL, Zhu X, Ziats NP, Fujioka H, Felsher DW, Castellani RJ, Valencik ML, McDonald JA, Hoit BD, Lesnefsky EJ, et al. Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. Plos One. 4: e7172. PMID 19779629 DOI: 10.1371/Journal.Pone.0007172  1
2009 Su B, Liu H, Wang X, Chen SG, Siedlak SL, Kondo E, Choi R, Takeda A, Castellani RJ, Perry G, Smith MA, Zhu X, Lee HG. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease. Molecular Neurodegeneration. 4: 32. PMID 19627592 DOI: 10.1186/1750-1326-4-32  1
2009 Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9090-103. PMID 19605646 DOI: 10.1523/Jneurosci.1357-09.2009  1
2009 Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. Journal of Alzheimer's Disease : Jad. 18: 447-52. PMID 19584435 DOI: 10.3233/Jad-2009-1151  1
2009 Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith MA, Zhu X, Moreira PI. Insulin is a two-edged knife on the brain. Journal of Alzheimer's Disease : Jad. 18: 483-507. PMID 19542630 DOI: 10.3233/Jad-2009-1155  1
2009 Dwyer BE, Stone ML, Gorman N, Sinclair PR, Perry G, Smith MA, Zhu X. Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease. Neuroscience Letters. 461: 302-5. PMID 19539709 DOI: 10.1016/j.neulet.2009.06.007  1
2009 Dwyer BE, Smith MA, Richardson SL, Perry G, Zhu X. Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease. Neuroscience Letters. 460: 180-4. PMID 19477221 DOI: 10.1016/j.neulet.2009.05.058  1
2009 Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J. Tau--an inhibitor of deacetylase HDAC6 function. Journal of Neurochemistry. 109: 1756-66. PMID 19457097 DOI: 10.1111/J.1471-4159.2009.06102.X  1
2009 Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neuroscience Letters. 455: 191-4. PMID 19429119 DOI: 10.1016/J.Neulet.2009.03.066  1
2009 Castellani RJ, Zhu X, Lee HG, Smith MA, Perry G. Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. International Journal of Molecular Sciences. 10: 1386-406. PMID 19399255 DOI: 10.3390/ijms10031386  1
2009 Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X. The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. Journal of Neurochemistry. 109: 153-9. PMID 19393022 DOI: 10.1111/J.1471-4159.2009.05867.X  1
2009 Reddy VP, Zhu X, Perry G, Smith MA. Oxidative stress in diabetes and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 763-74. PMID 19387111 DOI: 10.3233/JAD-2009-1013  1
2009 Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/Jad-2009-1021  1
2009 Perry G, Zhu X, Moreira PI, Smith MA. Altered redox balance in disease: can we change the new equilibria? Annals of Neurology. 65: 121-3. PMID 19259960 DOI: 10.1002/ana.21608  0.92
2009 Giliberto L, Borghi R, Piccini A, Mangerini R, Sorbi S, Cirmena G, Garuti A, Ghetti B, Tagliavini F, Mughal MR, Mattson MP, Zhu X, Wang X, Guglielmotto M, Tamagno E, et al. Mutant presenilin 1 increases the expression and activity of BACE1. The Journal of Biological Chemistry. 284: 9027-38. PMID 19196715 DOI: 10.1074/Jbc.M805685200  1
2009 Dwyer BE, Zacharski LR, Balestra DJ, Lerner AJ, Perry G, Zhu X, Smith MA. Getting the iron out: phlebotomy for Alzheimer's disease? Medical Hypotheses. 72: 504-9. PMID 19195795 DOI: 10.1016/j.mehy.2008.12.029  1
2009 Lee HP, Zhu X, Zhu X, Skidmore SC, Perry G, Sayre LM, Smith MA, Lee HG. The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells. Journal of Neurochemistry. 108: 1434-41. PMID 19183271 DOI: 10.1111/J.1471-4159.2009.05883.X  0.92
2009 Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American Journal of Pathology. 174: 891-7. PMID 19164506 DOI: 10.2353/Ajpath.2009.080583  1
2009 Tajes M, Yeste-Velasco M, Zhu X, Chou SP, Smith MA, Pallàs M, Camins A, Casadesús G. Activation of Akt by lithium: pro-survival pathways in aging. Mechanisms of Ageing and Development. 130: 253-61. PMID 19162061 DOI: 10.1016/j.mad.2008.12.006  1
2009 Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochemistry International. 54: 84-8. PMID 19114068 DOI: 10.1016/J.Neuint.2008.10.013  1
2009 Ramiro-Puig E, Casadesús G, Lee HG, Zhu X, McShea A, Perry G, Pérez-Cano FJ, Smith MA, Castell M. Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. European Journal of Nutrition. 48: 54-61. PMID 19043659 DOI: 10.1007/s00394-008-0761-4  1
2009 Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Research. 1249: 244-50. PMID 19026996 DOI: 10.1016/j.brainres.2008.10.055  1
2009 Bajic VP, Spremo-Potparevic B, Ilievski D, Zivkovic L, Zhu X, Smith MA. Astrin, a substrate of GSK3β is differentially expressed in AD compared to age-matched controls Alzheimers & Dementia. 5: 311. DOI: 10.1016/J.Jalz.2009.04.484  1
2009 Ramiro-Puig E, Casadesús G, Lee HG, Zhu X, McShea A, Perry G, Pérez-Cano FJ, Smith MA, Castell M. Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress (European Journal of Nutrition (2008)) European Journal of Nutrition. 48: 61. DOI: 10.1007/s00394-008-0766-z  1
2008 Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordrecht, Netherlands). 30: 209-15. PMID 19424844 DOI: 10.1007/S11357-008-9050-7  1
2008 Su B, Wang X, Nunomura A, Moreira PI, Lee HG, Perry G, Smith MA, Zhu X. Oxidative stress signaling in Alzheimer's disease. Current Alzheimer Research. 5: 525-32. PMID 19075578 DOI: 10.2174/156720508786898451  1
2008 Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 19318-23. PMID 19050078 DOI: 10.1073/Pnas.0804871105  1
2008 Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Reviews in Medicinal Chemistry. 8: 1395-406. PMID 18991755 DOI: 10.2174/138955708786369582  1
2008 Marlatt MW, Lucassen PJ, Perry G, Smith MA, Zhu X. Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease : Jad. 15: 199-210. PMID 18953109 DOI: 10.3233/Jad-2008-15206  1
2008 Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith MA, Tezapsidis N. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and Biophysical Research Communications. 376: 536-41. PMID 18801339 DOI: 10.1016/J.Bbrc.2008.09.026  1
2008 Bryan KJ, Zhu X, Harris PL, Perry G, Castellani RJ, Smith MA, Casadesus G. Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. Molecular Neurodegeneration. 3: 13. PMID 18786268 DOI: 10.1186/1750-1326-3-13  1
2008 Perry G, Castellani RJ, Moreira PI, Lee HG, Zhu X, Smith MA. Pathology's new role: defining disease process and protective responses. International Journal of Clinical and Experimental Pathology. 1: 1-4. PMID 18784818  1
2008 Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. International Journal of Clinical and Experimental Pathology. 1: 134-46. PMID 18784806  1
2008 Wang X, Su B, Fujioka H, Zhu X. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. The American Journal of Pathology. 173: 470-82. PMID 18599615 DOI: 10.2353/Ajpath.2008.071208  1
2008 Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA. Alzheimer disease pathology as a host response. Journal of Neuropathology and Experimental Neurology. 67: 523-31. PMID 18520771 DOI: 10.1097/NEN.0b013e318177eaf4  1
2008 Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA. Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of Neurochemistry. 106: 1350-6. PMID 18485104 DOI: 10.1111/J.1471-4159.2008.05477.X  1
2008 Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neuro-Degenerative Diseases. 5: 222-4. PMID 18322396 DOI: 10.1159/000113708  1
2008 Moreira PI, Santos MS, Oliveira CR, Shenk JC, Nunomura A, Smith MA, Zhu X, Perry G. Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Cns & Neurological Disorders Drug Targets. 7: 3-10. PMID 18289026 DOI: 10.2174/187152708783885156  1
2008 Su B, Wang X, Drew KL, Perry G, Smith MA, Zhu X. Physiological regulation of tau phosphorylation during hibernation. Journal of Neurochemistry. 105: 2098-108. PMID 18284615 DOI: 10.1111/J.1471-4159.2008.05294.X  1
2008 Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. Journal of Neuroscience Research. 86: 1711-20. PMID 18214993 DOI: 10.1002/Jnr.21622  1
2008 Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, ... ... Zhu X, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4: 151-75. PMID 18188003 DOI: 10.4161/Auto.5338  0.32
2008 Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, Muraca G, Danni O, Zhu X, Smith MA, Perry G, Jo DG, Mattson MP, Tabaton M. Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. Journal of Neurochemistry. 104: 683-95. PMID 18005001 DOI: 10.1111/J.1471-4159.2007.05072.X  1
2008 Zhu X, Siedlak SL, Wang Y, Perry G, Castellani RJ, Cohen ML, Smith MA. Neuronal binucleation in Alzheimer disease hippocampus. Neuropathology and Applied Neurobiology. 34: 457-65. PMID 17995921 DOI: 10.1111/J.1365-2990.2007.00908.X  1
2007 Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. Cns & Neurological Disorders Drug Targets. 6: 411-23. PMID 18220780 DOI: 10.2174/187152707783399201  1
2007 Wang X, Su B, Perry G, Smith MA, Zhu X. Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease. Free Radical Biology & Medicine. 43: 1569-73. PMID 18037122 DOI: 10.1016/J.Freeradbiomed.2007.09.007  1
2007 Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. Journal of Alzheimer's Disease : Jad. 12: 195-206. PMID 17917164 DOI: 10.3233/Jad-2007-12210  1
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 3: 614-5. PMID 17786024 DOI: 10.4161/Auto.4872  1
2007 Zhu X, Su B, Wang X, Smith MA, Perry G. Causes of oxidative stress in Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 64: 2202-10. PMID 17605000 DOI: 10.1007/S00018-007-7218-4  1
2007 Li J, Xia X, Ke Y, Nie H, Smith MA, Zhu X. Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways. Biochimica Et Biophysica Acta. 1770: 1169-80. PMID 17570595 DOI: 10.1016/j.bbagen.2007.04.007  1
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 66: 525-32. PMID 17549012 DOI: 10.1016/J.Jns.2009.02.162  1
2007 Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X. Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 11: 143-52. PMID 17522439 DOI: 10.3233/Jad-2007-11202  1
2007 Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X. Iron: the Redox-active center of oxidative stress in Alzheimer disease. Neurochemical Research. 32: 1640-5. PMID 17508283 DOI: 10.1007/S11064-007-9360-7  1
2007 Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA. BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. International Journal of Medical Sciences. 4: 140-5. PMID 17505559 DOI: 10.7150/Ijms.4.140  1
2007 Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Review of Neurotherapeutics. 7: 473-85. PMID 17492899 DOI: 10.1586/14737175.7.5.473  1
2007 Zhu X, Avila J, Perry G, Smith MA. Treating the lesions, not the disease. The American Journal of Pathology. 170: 1457-9. PMID 17456753 DOI: 10.2353/ajpath.2007.070193  1
2007 Thakur A, Wang X, Siedlak SL, Perry G, Smith MA, Zhu X. c-Jun phosphorylation in Alzheimer disease. Journal of Neuroscience Research. 85: 1668-73. PMID 17455299 DOI: 10.1002/Jnr.21298  1
2007 Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. Journal of the Neurological Sciences. 257: 240-6. PMID 17337008 DOI: 10.1016/J.Jns.2007.01.039  1
2007 Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Reviews in Medicinal Chemistry. 7: 171-80. PMID 17305591 DOI: 10.2174/138955707779802552  1
2007 Casadesus G, Smith MA, Basu S, Hua J, Capobianco DE, Siedlak SL, Zhu X, Perry G. Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Molecular Neurodegeneration. 2: 2. PMID 17241462 DOI: 10.1186/1750-1326-2-2  1
2007 Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. The Journal of Pharmacology and Experimental Therapeutics. 321: 823-9. PMID 17229880 DOI: 10.1124/jpet.106.114009  1
2007 Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: an update. Biochimica Et Biophysica Acta. 1772: 494-502. PMID 17142016 DOI: 10.1016/j.bbadis.2006.10.014  1
2007 Previll LA, Crosby ME, Castellani RJ, Bowser R, Perry G, Smith MA, Zhu X. Increased expression of p130 in Alzheimer disease. Neurochemical Research. 32: 639-44. PMID 17006760 DOI: 10.1007/S11064-006-9146-3  1
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532)) Journal of Neuropathology and Experimental Neurology. 66. DOI: 10.1097/01.Jnen.0000263876.99435.Cb  1
2007 Smith MA, Arendt T, Vincent I, Zhu X. Cell cycle dysregulation and neurodegenerative diseases Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1772: 391. DOI: 10.1016/J.Bbadis.2007.01.012  1
2006 Smith MA, Zhu X, Lee HG, Harris PL, Fortino AE, Perry G, Castellani RJ. Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy. Age (Dordrecht, Netherlands). 28: 85-91. PMID 23598681 DOI: 10.1007/S11357-006-9001-0  1
2006 Zhu X, Babar A, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG. LRRK2 in Parkinson's disease and dementia with Lewy bodies. Molecular Neurodegeneration. 1: 17. PMID 17137507 DOI: 10.1186/1750-1326-1-17  1
2006 Lee HG, Ueda M, Miyamoto Y, Yoneda Y, Perry G, Smith MA, Zhu X. Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease. Brain Research. 1124: 1-4. PMID 17070506 DOI: 10.1016/J.Brainres.2006.09.084  1
2006 Mei M, Su B, Harrison K, Chao M, Siedlak SL, Previll LA, Jackson L, Cai DX, Zhu X. Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. Journal of Neurochemistry. 99: 1377-88. PMID 17064357 DOI: 10.1111/J.1471-4159.2006.04174.X  1
2006 Nunomura A, Honda K, Takeda A, Hirai K, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in neurodegenerative diseases. Journal of Biomedicine & Biotechnology. 2006: 82323. PMID 17047315 DOI: 10.1155/Jbb/2006/82323  1
2006 Dwyer BE, Stone ML, Zhu X, Perry G, Smith MA. Heme deficiency in Alzheimer's disease: a possible connection to porphyria. Journal of Biomedicine & Biotechnology. 2006: 24038. PMID 17047301 DOI: 10.1155/JBB/2006/24038  1
2006 Webber KM, Stocco DM, Casadesus G, Bowen RL, Atwood CS, Previll LA, Harris PL, Zhu X, Perry G, Smith MA. Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Molecular Neurodegeneration. 1: 14. PMID 17018137 DOI: 10.1186/1750-1326-1-14  0.76
2006 Zhu X, Raina AK, Perry G, Smith MA. Apoptosis in Alzheimer disease: a mathematical improbability. Current Alzheimer Research. 3: 393-6. PMID 17017869 DOI: 10.2174/156720506778249470  1
2006 Lee HG, Ueda M, Zhu X, Perry G, Smith MA. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? Journal of Neuroscience Research. 84: 1856-61. PMID 16998902 DOI: 10.1002/jnr.21072  1
2006 Li J, Xia X, Nie H, Smith MA, Zhu X. PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562. Biochimica Et Biophysica Acta. 1770: 63-70. PMID 16949756 DOI: 10.1016/J.BBAGEN.2006.07.011  0.64
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! The American Journal of Pathology. 169: 738-9. PMID 16936250 DOI: 10.2353/ajpath.2006.060633  1
2006 Zhu X, Perry G, Moreira PI, Aliev G, Cash AD, Hirai K, Smith MA. Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. Journal of Alzheimer's Disease : Jad. 9: 147-53. PMID 16873962 DOI: 10.3233/JAD-2006-9207  1
2006 Zhu X, Siedlak SL, Smith MA, Perry G, Chen SG. LRRK2 protein is a component of Lewy bodies. Annals of Neurology. 60: 617-8; author reply . PMID 16847950 DOI: 10.1002/Ana.20928  1
2006 Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 65: 631-41. PMID 16825950 DOI: 10.1097/01.jnen.0000228136.58062.bf  1
2006 Lee HG, Perry G, Zhu X, Nunomura A, Smith MA. Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression". Free Radical Biology & Medicine. 41: 188-9. PMID 16814097 DOI: 10.1016/j.freeradbiomed.2006.03.014  1
2006 Moreira PI, Zhu X, Nunomura A, Smith MA, Perry G. Therapeutic options in Alzheimer's disease. Expert Review of Neurotherapeutics. 6: 897-910. PMID 16784412 DOI: 10.1586/14737175.6.6.897  1
2006 Lee HG, Zhu X, Takeda A, Perry G, Smith MA. Emerging evidence for the neuroprotective role of alpha-synuclein. Experimental Neurology. 200: 1-7. PMID 16780837 DOI: 10.1016/J.Expneurol.2006.04.024  1
2006 Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathologica. 111: 503-9. PMID 16718346 DOI: 10.1007/s00401-006-0071-y  1
2006 Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Science of Aging Knowledge Environment : Sage Ke. 2006: pe10. PMID 16672726 DOI: 10.1126/sageke.2006.8.pe10  1
2006 Moreira PI, Zhu X, Liu Q, Honda K, Siedlak SL, Harris PL, Smith MA, Perry G. Compensatory responses induced by oxidative stress in Alzheimer disease. Biological Research. 39: 7-13. PMID 16629160 DOI: 10.4067/S0716-97602006000100002  1
2006 Lee HG, Zhu X, Perry G, Smith MA. The fallacy of amyloid and cognition in Alzheimer's disease. Drugs & Aging. 23: 179. PMID 16536639 DOI: 10.2165/00002512-200623020-00007  1
2006 Zhu X, Lee HG, Moreira PI, Smith MA, Perry G. Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice". Free Radical Biology & Medicine. 40: 737-9. PMID 16520226 DOI: 10.1016/j.freeradbiomed.2005.12.028  1
2006 Moreira PI, Zhu X, Lee HG, Honda K, Smith MA, Perry G. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease. Mechanisms of Ageing and Development. 127: 501-6. PMID 16516950 DOI: 10.1016/j.mad.2006.01.024  1
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid beta: the alternate hypothesis. Current Alzheimer Research. 3: 75-80. PMID 16472207 DOI: 10.2174/156720506775697124  1
2006 Webber KM, Casadesus G, Zhu X, Obrenovich ME, Atwood CS, Perry G, Bowen RL, Smith MA. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current Pharmaceutical Design. 12: 691-7. PMID 16472159 DOI: 10.2174/138161206775474305  1
2006 Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. Brain and brawn: parallels in oxidative strength. Neurology. 66: S97-101. PMID 16432155 DOI: 10.1212/01.wnl.0000192307.15103.83  1
2006 Sha O, Kwong WH, Dong M, Wang X, Chan AK, Burns AJ, Chan WY, Castellani RJ, Zhu X, Lee H, Perry G, Smith MA, Casadesus G, Kanaumi T, Ichinohe A, et al. Contents Vol. 4, 2006–2007 Neuroembryology and Aging. 4. DOI: 10.1159/000121404  1
2006 Castellani RJ, Zhu X, Lee HG, Perry G, Smith MA, Casadesus G. Neurogenesis in human hippocampus: Implications for Alzheimer disease pathogenesis Neuroembryology and Aging. 4: 175-182. DOI: 10.1159/000118927  1
2005 Moreira PI, Honda K, Liu Q, Santos MS, Oliveira CR, Aliev G, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Current Alzheimer Research. 2: 403-8. PMID 16248845 DOI: 10.2174/156720505774330537  1
2005 Zhu X, Mei M, Lee HG, Wang Y, Han J, Perry G, Smith MA. P38 activation mediates amyloid-beta cytotoxicity. Neurochemical Research. 30: 791-6. PMID 16187214 DOI: 10.1007/s11064-005-6872-x  1
2005 Dwyer BE, Takeda A, Zhu X, Perry G, Smith MA. Ferric cycle activity and Alzheimer disease. Current Neurovascular Research. 2: 261-7. PMID 16181119 DOI: 10.2174/1567202054368371  1
2005 Moreira PI, Oliveira CR, Santos MS, Nunomura A, Honda K, Zhu X, Smith MA, Perry G. A second look into the oxidant mechanisms in Alzheimer's disease. Current Neurovascular Research. 2: 179-84. PMID 16181112 DOI: 10.2174/1567202053586758  1
2005 Zhu X, Moreira PI, Smith MA, Perry G. Alzheimer's disease: an intracellular movement disorder? Trends in Molecular Medicine. 11: 391-3. PMID 16087404 DOI: 10.1016/j.molmed.2005.07.002  1
2005 Liu G, Garrett MR, Men P, Zhu X, Perry G, Smith MA. Nanoparticle and other metal chelation therapeutics in Alzheimer disease. Biochimica Et Biophysica Acta. 1741: 246-52. PMID 16051470 DOI: 10.1016/j.bbadis.2005.06.006  1
2005 Moreira PI, Smith MA, Zhu X, Nunomura A, Castellani RJ, Perry G. Oxidative stress and neurodegeneration. Annals of the New York Academy of Sciences. 1043: 545-52. PMID 16037277 DOI: 10.1196/annals.1333.062  1
2005 Ma YL, Zhu X, Rivera PM, Tøien Ø, Barnes BM, LaManna JC, Smith MA, Drew KL. Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1297-306. PMID 15976308 DOI: 10.1152/Ajpregu.00260.2005  1
2005 Zhu X, Lee HG, Casadesus G, Avila J, Drew K, Perry G, Smith MA. Oxidative imbalance in Alzheimer's disease. Molecular Neurobiology. 31: 205-17. PMID 15953822 DOI: 10.1385/Mn:31:1-3:205  1
2005 Webber KM, Raina AK, Marlatt MW, Zhu X, Prat MI, Morelli L, Casadesus G, Perry G, Smith MA. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of Ageing and Development. 126: 1019-25. PMID 15936057 DOI: 10.1016/J.Mad.2005.03.024  1
2005 Lee HG, Castellani RJ, Zhu X, Perry G, Smith MA. Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective? International Journal of Experimental Pathology. 86: 133-8. PMID 15910547 DOI: 10.1111/j.0959-9673.2005.00429.x  1
2005 Marlatt MW, Webber KM, Moreira PI, Lee HG, Casadesus G, Honda K, Zhu X, Perry G, Smith MA. Therapeutic opportunities in Alzheimer disease: one for all or all for one? Current Medicinal Chemistry. 12: 1137-47. PMID 15892629 DOI: 10.2174/0929867053764644  1
2005 Zhu X, Smith MA, Perry G, Wang Y, Ross AP, Zhao HW, Lamanna JC, Drew KL. MAPKs are differentially modulated in arctic ground squirrels during hibernation. Journal of Neuroscience Research. 80: 862-8. PMID 15884016 DOI: 10.1002/Jnr.20526  1
2005 Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in Molecular Medicine. 11: 164-9. PMID 15823754 DOI: 10.1016/J.Molmed.2005.02.008  1
2005 Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/Jbc.M500526200  1
2005 Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, Perry G. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News & Perspectives. 18: 13-9. PMID 15753972 DOI: 10.1358/Dnp.2005.18.1.877164  1
2005 Zhu X, Perry G, Smith MA. Insulin signaling, diabetes mellitus and risk of Alzheimer disease. Journal of Alzheimer's Disease : Jad. 7: 81-4. PMID 15750216 DOI: 10.3233/JAD-2005-7108  1
2005 Casadesus G, Atwood CS, Zhu X, Hartzler AW, Webber KM, Perry G, Bowen RL, Smith MA. Evidence for the role of gonadotropin hormones in the development of Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 62: 293-8. PMID 15723165 DOI: 10.1007/S00018-004-4384-0  1
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/J.Freeradbiomed.2004.11.005  1
2005 Webber KM, Smith MA, Lee HG, Harris PL, Moreira P, Perry G, Zhu X. Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease. Journal of Neuroscience Research. 79: 554-60. PMID 15635602 DOI: 10.1002/jnr.20380  1
2005 Liu Q, Lee HG, Honda K, Siedlak SL, Harris PL, Cash AD, Zhu X, Avila J, Nunomura A, Takeda A, Smith MA, Perry G. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 211-5. PMID 15615639 DOI: 10.1016/J.Bbadis.2004.06.021  1
2005 Moreira PI, Siedlak SL, Aliev G, Zhu X, Cash AD, Smith MA, Perry G. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 921-32. PMID 15583960 DOI: 10.1007/S00702-004-0242-8  1
2005 Honda K, Moreira PI, Liu Q, Siedlak SL, Zhu X, Smith MA, Perry G. Redox active iron at the center of oxidative stress in Alzheimer disease Letters in Drug Design and Discovery. 2: 479-482. DOI: 10.2174/1570180054771545  1
2004 Moreira PI, Smith MA, Zhu X, Santos MS, Oliveira CR, Perry G. Therapeutic potential of oxidant mechanisms in Alzheimer's disease. Expert Review of Neurotherapeutics. 4: 995-1004. PMID 15853526 DOI: 10.1586/14737175.4.6.995  1
2004 Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience. 7: 309-16. PMID 15682927 DOI: 10.1080/10284150400020482  1
2004 Zhu X, Smith MA, Perry G, Aliev G. Mitochondrial failures in Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementias. 19: 345-52. PMID 15633943 DOI: 10.1177/153331750401900611  1
2004 Lee HG, Moreira PI, Zhu X, Smith MA, Perry G. Staying connected: synapses in Alzheimer disease. The American Journal of Pathology. 165: 1461-4. PMID 15509517 DOI: 10.1016/S0002-9440(10)63404-9  1
2004 Casadesus G, Zhu X, Atwood CS, Webber KM, Perry G, Bowen RL, Smith MA. Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease. Current Drug Targets. Cns and Neurological Disorders. 3: 281-5. PMID 15379604 DOI: 10.2174/1568007043337265  1
2004 Takeda A, Itoyama Y, Kimpara T, Zhu X, Avila J, Dwyer BE, Perry G, Smith MA. Heme catabolism and heme oxygenase in neurodegenerative disease. Antioxidants & Redox Signaling. 6: 888-94. PMID 15345149 DOI: 10.1089/Ars.2004.6.888  1
2004 Drew KL, Harris MB, LaManna JC, Smith MA, Zhu XW, Ma YL. Hypoxia tolerance in mammalian heterotherms. The Journal of Experimental Biology. 207: 3155-62. PMID 15299037 DOI: 10.1242/Jeb.01114  1
2004 Zhu X, Webber KM, Casadesus G, Raina AK, Lee HG, Marlatt M, Hartzler A, Atwood CS, Perry G, Smith MA. Mitotic and gender parallels in Alzheimer disease: therapeutic opportunities. Current Drug Targets. 5: 559-63. PMID 15270202 DOI: 10.2174/1389450043345317  1
2004 Ma YL, Rice ME, Chao ML, Rivera PM, Zhao HW, Ross AP, Zhu X, Smith MA, Drew KL. Ascorbate distribution during hibernation is independent of ascorbate redox state. Free Radical Biology & Medicine. 37: 511-20. PMID 15256222 DOI: 10.1016/j.freeradbiomed.2004.04.025  1
2004 Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA. Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Annals of the New York Academy of Sciences. 1019: 1-4. PMID 15246983 DOI: 10.1196/Annals.1297.001  1
2004 Castellani RJ, Honda K, Zhu X, Cash AD, Nunomura A, Perry G, Smith MA. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Research Reviews. 3: 319-26. PMID 15231239 DOI: 10.1016/j.arr.2004.01.002  1
2004 Raina AK, Zhu X, Smith MA. Alzheimer's disease and the cell cycle. Acta Neurobiologiae Experimentalis. 64: 107-12. PMID 15190685  1
2004 Lee HG, Zhu X, O'Neill MJ, Webber K, Casadesus G, Marlatt M, Raina AK, Perry G, Smith MA. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 89-98. PMID 15190683  1
2004 Marlatt M, Lee HG, Perry G, Smith MA, Zhu X. Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 81-7. PMID 15190682  1
2004 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/J.1471-4159.2004.02416.X  1
2004 Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, Petersen RB, Perry G. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. Journal of Alzheimer's Disease : Jad. 6: 165-9. PMID 15096700 DOI: 10.3233/Jad-2004-6208  1
2004 Lee HG, Casadesus G, Zhu X, Joseph JA, Perry G, Smith MA. Perspectives on the amyloid-beta cascade hypothesis. Journal of Alzheimer's Disease : Jad. 6: 137-45. PMID 15096697 DOI: 10.3233/Jad-2004-6205  1
2004 Zhu X, Raina AK, Lee HG, Casadesus G, Smith MA, Perry G. Oxidative stress signalling in Alzheimer's disease. Brain Research. 1000: 32-9. PMID 15053949 DOI: 10.1016/J.Brainres.2004.01.012  1
2004 Zhu X, Raina AK, Perry G, Smith MA. Alzheimer's disease: the two-hit hypothesis. The Lancet. Neurology. 3: 219-26. PMID 15039034 DOI: 10.1016/S1474-4422(04)00707-0  1
2004 Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. Journal of Neuroscience Research. 75: 698-703. PMID 14991845 DOI: 10.1002/Jnr.20028  1
2004 Lee HG, Ogawa O, Zhu X, O'Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA. Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease. Acta Neuropathologica. 107: 365-71. PMID 14872255 DOI: 10.1007/S00401-004-0820-8  1
2004 Zhu X, Perry G, Smith MA. Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway. Redox Report : Communications in Free Radical Research. 8: 129-33. PMID 12935309 DOI: 10.1179/135100003225001494  0.4
2003 Raina AK, Zhu X, Shimohama S, Perry G, Smith MA. Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept. Cell Biochemistry and Biophysics. 39: 249-55. PMID 14716079 DOI: 10.1385/Cbb:39:3:249  1
2003 Lee HG, Petersen RB, Zhu X, Honda K, Aliev G, Smith MA, Perry G. Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain Pathology (Zurich, Switzerland). 13: 630-8. PMID 14655766 DOI: 10.1111/J.1750-3639.2003.Tb00491.X  1
2003 Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA. Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. Antioxidants & Redox Signaling. 5: 571-6. PMID 14580312 DOI: 10.1089/152308603770310220  1
2003 Ogawa O, Lee HG, Zhu X, Raina A, Harris PL, Castellani RJ, Perry G, Smith MA. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell. 2: 105-10. PMID 12882323 DOI: 10.1046/J.1474-9728.2003.00042.X  1
2003 Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA. Distribution, levels, and activation of MEK1 in Alzheimer's disease. Journal of Neurochemistry. 86: 136-42. PMID 12807433 DOI: 10.1046/J.1471-4159.2003.01820.X  1
2003 Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avíla J, Jones PK, Castellani RJ, Smith MA, et al. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. The American Journal of Pathology. 162: 1623-7. PMID 12707046 DOI: 10.1016/S0002-9440(10)64296-4  1
2003 Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, Ghanbari HA, Castellani RJ, Perry G, Smith MA. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathologica. 105: 524-8. PMID 12677454 DOI: 10.1007/S00401-003-0684-3  1
2003 Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 251-4. PMID 12657364 DOI: 10.1016/S0278-5846(03)00020-4  1
2003 Zhu X, Ogawa O, Wang Y, Perry G, Smith MA. JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease. Journal of Neurochemistry. 85: 87-93. PMID 12641730 DOI: 10.1046/J.1471-4159.2003.01645.X  0.56
2002 Ogawa O, Zhu X, Perry G, Smith MA. Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease. Science of Aging Knowledge Environment : Sage Ke. 2002: pe16. PMID 14603007 DOI: 10.1126/Sageke.2002.41.Pe16  0.56
2002 Lee HG, Zhu X, Ghanbari HA, Ogawa O, Raina AK, O'Neill MJ, Perry G, Smith MA. Differential regulation of glutamate receptors in Alzheimer's disease. Neuro-Signals. 11: 282-92. PMID 12566929 DOI: 10.1159/000067427  1
2002 Zhu X, Lee HG, Raina AK, Perry G, Smith MA. The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neuro-Signals. 11: 270-81. PMID 12566928 DOI: 10.1159/000067426  1
2002 Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 133: 507-13. PMID 12458179 DOI: 10.1016/S1532-0456(02)00119-9  1
2002 Perry G, Nunomura A, Hirai K, Zhu X, Pérez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology & Medicine. 33: 1475-9. PMID 12446204 DOI: 10.1016/S0891-5849(02)01113-9  1
2002 Hartzler AW, Zhu X, Siedlak SL, Castellani RJ, Avilá J, Perry G, Smith MA. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Neurobiology of Aging. 23: 855-9. PMID 12392790 DOI: 10.1016/S0197-4580(02)00029-5  1
2002 Cash AD, Perry G, Ogawa O, Raina AK, Zhu X, Smith MA. Is Alzheimer's disease a mitochondrial disorder? The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 489-96. PMID 12374431 DOI: 10.1177/107385802236968  1
2002 Zhou F, Braddock JF, Hu Y, Zhu X, Castellani RJ, Smith MA, Drew KL. Microbial origin of glutamate, hibernation and tissue trauma: an in vivo microdialysis study. Journal of Neuroscience Methods. 119: 121-8. PMID 12323415 DOI: 10.1016/S0165-0270(02)00177-2  1
2002 Clapp-Lilly KL, Smith MA, Perry G, Harris PL, Zhu X, Drew KL, Duffy LK. Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity. International Journal of Circumpolar Health. 61: 32-40. PMID 12002945 DOI: 10.3402/Ijch.V61I1.17403  1
2002 Smith MA, Drew KL, Nunomura A, Takeda A, Hirai K, Zhu X, Atwood CS, Raina AK, Rottkamp CA, Sayre LM, Friedland RP, Perry G. Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochemistry International. 40: 527-31. PMID 11850109 DOI: 10.1016/S0197-0186(01)00123-1  1
2001 Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Journal of Neurochemistry. 79: 311-8. PMID 11677259 DOI: 10.1046/J.1471-4159.2001.00597.X  1
2001 Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mechanisms of Ageing and Development. 123: 39-46. PMID 11640950 DOI: 10.1016/S0047-6374(01)00342-6  1
2001 Raina AK, Pardo P, Rottkamp CA, Zhu X, Pereira-Smith OM, Smith MA. Neurons in Alzheimer disease emerge from senescence. Mechanisms of Ageing and Development. 123: 3-9. PMID 11640946 DOI: 10.1016/S0047-6374(01)00333-5  1
2001 Zhou F, Zhu X, Castellani RJ, Stimmelmayr R, Perry G, Smith MA, Drew KL. Hibernation, a model of neuroprotection. The American Journal of Pathology. 158: 2145-51. PMID 11395392 DOI: 10.1016/S0002-9440(10)64686-X  1
2001 Raina AK, Hochman A, Zhu X, Rottkamp CA, Nunomura A, Siedlak SL, Boux H, Castellani RJ, Perry G, Smith MA. Abortive apoptosis in Alzheimer's disease. Acta Neuropathologica. 101: 305-10. PMID 11355301 DOI: 10.1007/S004010100378  1
2001 Clapp-Lilly KL, Smith MA, Perry G, Harris PL, Zhu X, Duffy LK. Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease. Neuroreport. 12: 1277-80. PMID 11338206 DOI: 10.1097/00001756-200105080-00044  1
2001 Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. Journal of Neurochemistry. 76: 435-41. PMID 11208906 DOI: 10.1046/J.1471-4159.2001.00046.X  1
2001 Rottkamp CA, Raina AK, Zhu X, Gaier E, Bush AI, Atwood CS, Chevion M, Perry G, Smith MA. Redox-active iron mediates amyloid-beta toxicity. Free Radical Biology & Medicine. 30: 447-50. PMID 11182300 DOI: 10.1016/S0891-5849(00)00494-9  1
2000 Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G. Protein disulfide isomerase in Alzheimer disease. Antioxidants & Redox Signaling. 2: 485-9. PMID 11229362 DOI: 10.1089/15230860050192260  1
2000 Smith MA, Nunomura A, Zhu X, Takeda A, Perry G. Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxidants & Redox Signaling. 2: 413-20. PMID 11229355 DOI: 10.1089/15230860050192198  1
2000 Harris PL, Zhu X, Pamies C, Rottkamp CA, Ghanbari HA, McShea A, Feng Y, Ferris DK, Smith MA. Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes. Neurobiology of Aging. 21: 837-41. PMID 11124427 DOI: 10.1016/S0197-4580(00)00218-9  1
2000 Zhu X, Rottkamp CA, Raina AK, Brewer GJ, Ghanbari HA, Boux H, Smith MA. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Neurobiology of Aging. 21: 807-13. PMID 11124424 DOI: 10.1016/S0197-4580(00)00217-7  1
2000 Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA. Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 59: 880-8. PMID 11079778 DOI: 10.1093/JNEN/59.10.880  1
2000 Takeda A, Smith MA, Avilá J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. Journal of Neurochemistry. 75: 1234-41. PMID 10936206 DOI: 10.1046/J.1471-4159.2000.0751234.X  1
2000 Raina AK, Zhu X, Rottkamp CA, Monteiro M, Takeda A, Smith MA. Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. Journal of Neuroscience Research. 61: 128-33. PMID 10878584 DOI: 10.1002/1097-4547(20000715)61:2<128::Aid-Jnr2>3.0.Co;2-H  1
2000 Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA. Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 18: 433-7. PMID 10817927 DOI: 10.1016/S0736-5748(00)00010-1  1
2000 Raina AK, Zhu X, Monteiro M, Takeda A, Smith MA. Abortive oncogeny and cell cycle-mediated events in Alzheimer disease. Progress in Cell Cycle Research. 4: 235-42. PMID 10740829 DOI: 10.1007/978-1-4615-4253-7_20  1
1999 Perry G, Roder H, Nunomura A, Takeda A, Friedlich AL, Zhu X, Raina AK, Holbrook N, Siedlak SL, Harris PL, Smith MA. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport. 10: 2411-5. PMID 10439473 DOI: 10.1097/00001756-199908020-00035  1
1999 Zhu X, Raina AK, Smith MA. Cell cycle events in neurons. Proliferation or death? The American Journal of Pathology. 155: 327-9. PMID 10433924 DOI: 10.1016/S0002-9440(10)65127-9  1
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