Giles S. H. Yeo, PhD - Publications

Affiliations: 
Institute of Metabolic Science University of Cambridge, Cambridge, England, United Kingdom 
Area:
Metabolism, Genetics, Genomics

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells (Molecular metabolism. 2019 Nov;29:158-169). Molecular Metabolism. 101399. PMID 34863700 DOI: 10.1016/j.molmet.2021.101399  0.573
2020 Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, et al. Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy. Molecular Metabolism. 101118. PMID 33221554 DOI: 10.1016/j.molmet.2020.101118  0.588
2020 Thackray AM, Lam B, Shahira Binti Ab Razak A, Yeo G, Bujdoso R. Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease. The Biochemical Journal. 477: 833-852. PMID 32108870 DOI: 10.1042/BCJ20190872  0.591
2020 Melvin A, Cowan C, Lam B, Buller S, Rainbow K, Yeo GS, O’Rahilly S. SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.2097  0.635
2019 Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells. Molecular Metabolism. 29: 158-169. PMID 31668387 DOI: 10.1016/J.Molmet.2019.09.001  0.578
2019 Clément M, Raffort J, Lareyre F, Tsiantoulas D, Newland SA, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MK, Ozsvar-Kozma M, Lam B, Yeo GS, Binder CJ, Kaser A, et al. Impaired Autophagy in CD11b Dendritic Cells Expands CD4 Regulatory T Cells And Limits Atherosclerosis in Mice. Circulation Research. PMID 31610723 DOI: 10.1161/Circresaha.119.315248  0.608
2019 Al-Massadi O, Quiñones M, Clasadonte J, Bautista RH, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, ... ... Yeo G, et al. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity and Glucose Intolerance. Diabetes. PMID 31530579 DOI: 10.2337/Db19-0029  0.371
2018 Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, ... ... Yeo G, et al. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nature Communications. 9: 3432. PMID 30143607 DOI: 10.1038/S41467-018-05711-6  0.41
2018 Polex-Wolf J, Lam BY, Larder R, Tadross J, Rimmington D, Bosch F, Cenzano VJ, Ayuso E, Ma MK, Rainbow K, Coll AP, O'Rahilly S, Yeo GS. Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome. The Journal of Clinical Investigation. PMID 29376887 DOI: 10.1172/Jci97007  0.764
2018 Basatemur G, Ackers-Johnson M, Schoonejans J, Kazachenka A, Lam B, Ma M, Brimpari M, Patel M, Saleh N, Murphy D, Zhao T, Yeo G, Ferguson-Smith A, Vallier L, Sinha S, et al. 129 The CHR9P21 risk locus affects IL-1/TLR signalling in VSMC Heart. 104. DOI: 10.1136/Heartjnl-2018-Bcs.128  0.595
2017 Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett J. Selective Rab11 transport and the intrinsic regenerative ability of CNS axons. Elife. 6. PMID 28829741 DOI: 10.7554/Elife.26956  0.525
2017 Challis BG, Powlson AS, Casey RT, Pearson C, Lam B, Ma M, Pitfield D, Yeo G, Godfrey E, Cheow H, Chatterjee VK, Carroll N, Shaw A, Buscombe J, Simpson HL. Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management. Endocrine Connections. PMID 28784625 DOI: 10.1530/Ec-17-0076  0.552
2016 Yeo GS. Genetics of obesity: can an old dog teach us new tricks? Diabetologia. PMID 28013339 DOI: 10.1007/S00125-016-4187-X  0.439
2016 Polex-Wolf J, Yeo GS, O'Rahilly S. Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome? The Journal of Clinical Investigation. PMID 27941250 DOI: 10.1172/Jci91307  0.759
2016 Zhou J, Lam B, Neogi SG, Yeo GS, Azizan EA, Brown MJ. Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues. Hypertension (Dallas, Tex. : 1979). PMID 27777363 DOI: 10.1161/Hypertensionaha.116.08033  0.632
2016 Zhou J, Lam B, Neogi S, Yeo G, Azizan E, Brown M. ISH ADA-04 TRANSCRIPTOME PATHWAY ANALYSIS OF AUTONOMOUS AND PHYSIOLOGICAL ALDOSTERONE-PRODUCING HUMAN TISSUE. Journal of Hypertension. 34: e40. PMID 27643206 DOI: 10.1097/01.Hjh.0000499958.18632.E9  0.602
2016 Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology. en20161314. PMID 27583789 DOI: 10.1210/En.2016-1314  0.379
2016 Zhou J, Lam BY, Neogi SG, Yeo GS, Teo AE, Maniero C, Azizan EA, Brown MJ. [OP.3A.01] THE COMPARISON OF THE TRANSCRIPTOME PROFILE OF THE AUTONOMOUS AND THE PHYSIOLOGICAL ALDOSTERONE-PRODUCING TISSUE, THE ALDOSTERONE-PRODUCING ADENOMA AND THE ZONA GLOMERULOSA. Journal of Hypertension. 34: e26. PMID 27508643 DOI: 10.1097/01.Hjh.0000491398.48468.Bf  0.597
2016 Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia. PMID 27390011 DOI: 10.1007/S00125-016-4033-1  0.599
2016 Raffan E, Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E, Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, ... ... Yeo GS, et al. A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism. PMID 27157046 DOI: 10.1016/J.Cmet.2016.04.012  0.549
2016 Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, ... ... Yeo GS, et al. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metabolism. PMID 27133129 DOI: 10.1016/J.Cmet.2016.04.003  0.668
2016 Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, ... ... Yeo GS, et al. Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 164: 353-364. PMID 26824653 DOI: 10.1016/J.Cell.2015.12.025  0.727
2016 Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Disease Models & Mechanisms. PMID 26769798 DOI: 10.1242/Dev.138396  0.32
2016 O'Rahilly S, Coll AP, Yeo GS. FTO Obesity Variant and Adipocyte Browning in Humans. The New England Journal of Medicine. 374: 191. PMID 26760098 DOI: 10.1056/Nejmc1513316#Sa2  0.555
2015 Ye L, Goodall JC, Zhang L, Putintseva EV, Lam B, Jiang L, Liu W, Yin J, Lin L, Li T, Wu X, Yeo G, Shugay M, Chudakov DM, Gaston H, et al. TCR usage, gene expression and function of two distinct FOXP3+Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO. Immunology and Cell Biology. PMID 26467610 DOI: 10.1038/Icb.2015.90  0.574
2015 Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O'Rahilly S, Coll AP, Yeo GS. FTO is necessary for the induction of leptin resistance by high-fat feeding. Molecular Metabolism. 4: 287-98. PMID 25830092 DOI: 10.1016/J.Molmet.2015.01.011  0.548
2015 Trivedi C, Shan X, Tung YC, Kabra D, Holland J, Amburgy S, Heppner K, Kirchner H, Yeo GS, Perez-Tilve D. Tachykinin-1 in the central nervous system regulates adiposity in rodents. Endocrinology. 156: 1714-23. PMID 25751638 DOI: 10.1210/En.2014-1781  0.402
2014 Tung YC, Yeo GS, O'Rahilly S, Coll AP. Obesity and FTO: Changing Focus at a Complex Locus. Cell Metabolism. 20: 710-8. PMID 25448700 DOI: 10.1016/J.Cmet.2014.09.010  0.587
2014 Gulati P, Avezov E, Ma M, Antrobus R, Lehner P, O'Rahilly S, Yeo GS. Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm. Bioscience Reports. 34. PMID 25242086 DOI: 10.1042/Bsr20140111  0.528
2014 Yeo GS. The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition. Molecular and Cellular Endocrinology. 397: 34-41. PMID 25224490 DOI: 10.1016/J.Mce.2014.09.012  0.476
2014 Schlosberg A, Lam BY, Yeo GS, Clifton-Bligh RJ. DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification. International Journal of Molecular Sciences. 15: 8491-508. PMID 24828207 DOI: 10.3390/Ijms15058491  0.598
2014 Carr SK, Chen JH, Cooper WN, Constância M, Yeo GS, Ozanne SE. Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2191-201. PMID 24481968 DOI: 10.1096/Fj.13-242727  0.312
2014 Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. 10: 51-61. PMID 24247219 DOI: 10.1038/Nrendo.2013.227  0.424
2014 Raffan E, Becker J, Yeo G, O'Rahilly S. The coding sequence of POMC and obesity and appetite in Labrador retriever dogs The Lancet. 383: S86. DOI: 10.1016/S0140-6736(14)60349-4  0.565
2013 Goodall JC, Yeo GS. PP2Ce: Fat and stressed out? Molecular Metabolism. 2: 325-6. PMID 24327947 DOI: 10.1016/J.Molmet.2013.08.009  0.365
2013 Gulati P, Yeo GS. The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia. 56: 2113-21. PMID 23896822 DOI: 10.1007/S00125-013-2999-5  0.427
2013 Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proceedings of the National Academy of Sciences of the United States of America. 110: 2557-62. PMID 23359686 DOI: 10.1073/Pnas.1222796110  0.585
2013 McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O'Rahilly S, Ashcroft FM, Coll AP, Cox RD. Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. Plos Genetics. 9: e1003166. PMID 23300482 DOI: 10.1371/Journal.Pgen.1003166  0.531
2013 Chadt A, Yeo GS, Al-Hasani H. Nutrition-/diet-induced changes in gene expression in pancreatic β-cells. Diabetes, Obesity & Metabolism. 57-67. PMID 22928565 DOI: 10.1111/J.1463-1326.2012.01640.X  0.319
2013 Cheung MK, Gulati P, O'Rahilly S, Yeo GS. FTO expression is regulated by availability of essential amino acids. International Journal of Obesity (2005). 37: 744-7. PMID 22614055 DOI: 10.1038/Ijo.2012.77  0.528
2012 Yeo GS, O'Rahilly S. Uncovering the biology of FTO. Molecular Metabolism. 1: 32-6. PMID 24024116 DOI: 10.1016/J.Molmet.2012.06.001  0.569
2012 Yeo GS, Heisler LK. Unraveling the brain regulation of appetite: lessons from genetics. Nature Neuroscience. 15: 1343-9. PMID 23007189 DOI: 10.1038/Nn.3211  0.43
2012 Ma M, Harding HP, O'Rahilly S, Ron D, Yeo GS. Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. The Biochemical Journal. 444: 183-7. PMID 22435707 DOI: 10.1042/Bj20120065  0.522
2012 Yeo GS. FTO and obesity: a problem for a billion people. Journal of Neuroendocrinology. 24: 393-4. PMID 22248259 DOI: 10.1111/J.1365-2826.2011.02254.X  0.418
2011 Cheung MK, Yeo GS. FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More? Frontiers in Endocrinology. 2: 4. PMID 22649359 DOI: 10.3389/Fendo.2011.00004  0.434
2011 Tung YC, Yeo GS. From GWAS to biology: lessons from FTO. Annals of the New York Academy of Sciences. 1220: 162-71. PMID 21388413 DOI: 10.1111/J.1749-6632.2010.05903.X  0.403
2011 Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP. Where to go with FTO? Trends in Endocrinology and Metabolism: Tem. 22: 53-9. PMID 21131211 DOI: 10.1016/J.Tem.2010.11.001  0.426
2011 Gumy LF, Yeo GS, Tung YC, Zivraj KH, Willis D, Coppola G, Lam BY, Twiss JL, Holt CE, Fawcett JW. Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization. Rna (New York, N.Y.). 17: 85-98. PMID 21098654 DOI: 10.1261/Rna.2386111  0.574
2011 Stewart L, Hindmarch CC, Qiu J, Tung YC, Yeo GS, Murphy D. Hypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways. Journal of Neuroendocrinology. 23: 177-85. PMID 21070396 DOI: 10.1111/J.1365-2826.2010.02093.X  0.33
2010 Jovanovic Z, Tung YC, Lam BY, O'Rahilly S, Yeo GS. Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. Journal of Neuroendocrinology. 22: 915-25. PMID 20553370 DOI: 10.1111/J.1365-2826.2010.02026.X  0.705
2010 Jovanovic Z, Yeo GS. Central leptin signalling: beyond the arcuate nucleus. Autonomic Neuroscience : Basic & Clinical. 156: 8-14. PMID 20547475 DOI: 10.1016/J.Autneu.2010.05.008  0.318
2010 Chen JH, Tarry-Adkins JL, Matharu K, Yeo GS, Ozanne SE. Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications for the regulation of renal function and lifespan. Clinical Science (London, England : 1979). 119: 373-84. PMID 20528770 DOI: 10.1042/Cs20100230  0.321
2010 Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. Plos One. 5: e8771. PMID 20098739 DOI: 10.1371/Journal.Pone.0008771  0.541
2010 Romeo S, Sentinelli F, Dash S, Yeo GS, Savage DB, Leonetti F, Capoccia D, Incani M, Maglio C, Iacovino M, O'Rahilly S, Baroni MG. Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. International Journal of Obesity (2005). 34: 190-4. PMID 19844213 DOI: 10.1038/Ijo.2009.216  0.495
2010 Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, ... ... Yeo GS, et al. Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes. 59: 311-8. PMID 19833892 DOI: 10.2337/Db09-0703  0.588
2009 Dreja T, Jovanovic Z, Rasche A, Kluge R, Herwig R, Tung YC, Joost HG, Yeo GS, Al-Hasani H. Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome. Diabetologia. 53: 309-20. PMID 19902174 DOI: 10.1007/S00125-009-1576-4  0.347
2009 Oswal A, Yeo G. Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity. Obesity (Silver Spring, Md.). 18: 221-9. PMID 19644451 DOI: 10.1038/Oby.2009.228  0.389
2009 Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. American Journal of Human Genetics. 85: 106-11. PMID 19559399 DOI: 10.1016/J.Ajhg.2009.06.002  0.549
2009 de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, et al. A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Human Molecular Genetics. 18: 3257-65. PMID 19498035 DOI: 10.1093/Hmg/Ddp263  0.574
2009 Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CS, Soos MA, Clark J, Rodin A, Langenberg C, Druet C, Fawcett KA, Tung YC, Wareham NJ, Barroso I, et al. A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Proceedings of the National Academy of Sciences of the United States of America. 106: 9350-5. PMID 19470471 DOI: 10.1073/Pnas.0900909106  0.49
2009 Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS. Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. Endocrinology. 150: 114-25. PMID 18801902 DOI: 10.1210/En.2008-0721  0.554
2008 Coll AP, Yeo GS, Farooqi IS, O'Rahilly S. SnapShot: the hormonal control of food intake. Cell. 135: 572.e1-2. PMID 18984167 DOI: 10.1016/J.Cell.2008.10.014  0.479
2008 Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology. 149: 1323-8. PMID 18039773 DOI: 10.1210/En.2007-1321  0.508
2007 Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (New York, N.Y.). 318: 1469-72. PMID 17991826 DOI: 10.1126/Science.1151710  0.556
2007 Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6956-64. PMID 17596444 DOI: 10.1523/Jneurosci.2584-06.2007  0.432
2007 Oswal A, Yeo GS. The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obesity Reviews : An Official Journal of the International Association For the Study of Obesity. 8: 293-306. PMID 17578380 DOI: 10.1111/J.1467-789X.2007.00378.X  0.452
2007 Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Plos Genetics. 3: e64. PMID 17465682 DOI: 10.1371/Journal.Pgen.0030064  0.32
2007 Gray J, Yeo G, Hung C, Keogh J, Clayton P, Banerjee K, McAulay A, O'Rahilly S, Farooqi IS. Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity International Journal of Obesity. 31: 359-364. PMID 16702999 DOI: 10.1038/Sj.Ijo.0803390  0.576
2006 Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR, Raymond FL, O'rahilly S, Farooqi IS. Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes. 55: 3366-71. PMID 17130481 DOI: 10.2337/Db06-0550  0.541
2006 Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, et al. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metabolism. 3: 135-40. PMID 16459314 DOI: 10.1016/J.Cmet.2006.01.006  0.538
2005 Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, et al. Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1108-19. PMID 15985534 DOI: 10.1096/Fj.04-3196Com  0.468
2004 Yeo GS, Connie Hung CC, Rochford J, Keogh J, Gray J, Sivaramakrishnan S, O'Rahilly S, Farooqi IS. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nature Neuroscience. 7: 1187-9. PMID 15494731 DOI: 10.1038/Nn1336  0.56
2004 Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS. Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. Diabetes. 53: 2461-6. PMID 15331560 DOI: 10.2337/Diabetes.53.9.2461  0.586
2004 Coll AP, Challis BG, Yeo GS, Snell K, Piper SJ, Halsall D, Thresher RR, O'Rahilly S. The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin. Endocrinology. 145: 4721-7. PMID 15231703 DOI: 10.1210/En.2004-0491  0.49
2004 Coll AP, Farooqi IS, Challis BG, Yeo GS, O'Rahilly S. Proopiomelanocortin and energy balance: insights from human and murine genetics. The Journal of Clinical Endocrinology and Metabolism. 89: 2557-62. PMID 15181023 DOI: 10.1210/Jc.2004-0428  0.483
2004 Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proceedings of the National Academy of Sciences of the United States of America. 101: 4695-700. PMID 15070780 DOI: 10.1073/Pnas.0306931101  0.566
2004 O'Rahilly S, Yeo GS, Farooqi IS. Melanocortin receptors weigh in. Nature Medicine. 10: 351-2. PMID 15057231 DOI: 10.1038/Nm0404-351  0.491
2004 Laudes M, Barroso I, Luan J, Soos MA, Yeo G, Meirhaeghe A, Logie L, Vidal-Puig A, Schafer AJ, Wareham NJ, O'Rahilly S. Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes. Diabetes. 53: 842-6. PMID 14988272 DOI: 10.2337/Diabetes.53.3.842  0.503
2003 Donohoue PA, Tao YX, Collins M, Yeo GS, O'Rahilly S, Segaloff DL. Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female. The Journal of Clinical Endocrinology and Metabolism. 88: 5841-5. PMID 14671178 DOI: 10.1210/Jc.2003-030903  0.593
2003 Yeo GS, Siddle K. Attractin' more attention - new pieces in the obesity puzzle? The Biochemical Journal. 376: e7-8. PMID 14656215 DOI: 10.1042/Bj20031675  0.358
2003 O'Rahilly S, Farooqi IS, Yeo GS, Challis BG. Minireview: human obesity-lessons from monogenic disorders. Endocrinology. 144: 3757-64. PMID 12933645 DOI: 10.1210/En.2003-0373  0.574
2003 Farooqi IS, Yeo GS, O'Rahilly S. Binge eating as a phenotype of melanocortin 4 receptor gene mutations. The New England Journal of Medicine. 349: 606-9; author reply . PMID 12908459  0.432
2003 Hung CC, Farooqi IS, Ong K, Luan J, Keogh JM, Pembrey M, Yeo GS, Dunger D, Wareham NJ, O' Rahilly S. Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations. Diabetes. 52: 1288-91. PMID 12716767 DOI: 10.2337/Diabetes.52.5.1288  0.408
2003 Meirhaeghe A, Crowley V, Lenaghan C, Lelliott C, Green K, Stewart A, Hart K, Schinner S, Sethi JK, Yeo G, Brand MD, Cortright RN, O'Rahilly S, Montague C, Vidal-Puig AJ. Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. The Biochemical Journal. 373: 155-65. PMID 12678921 DOI: 10.1042/Bj20030200  0.48
2003 Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. The New England Journal of Medicine. 348: 1085-95. PMID 12646665 DOI: 10.1056/Nejmoa022050  0.565
2003 Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S. Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Human Molecular Genetics. 12: 561-74. PMID 12588803 DOI: 10.1093/Hmg/Ddg057  0.534
2002 Challis BG, Yeo GS. Past, present and future strategies to study the genetics of body weight regulation. Briefings in Functional Genomics & Proteomics. 1: 290-304. PMID 15239895 DOI: 10.1093/Bfgp/1.3.290  0.44
2002 Berger D, Barroso I, Soos M, Yeo G, Schafer AJ, O'Rahilly S, Whitehead JP. Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1. Diabetic Medicine : a Journal of the British Diabetic Association. 19: 804-9. PMID 12358865 DOI: 10.1046/J.1464-5491.2002.00779.X  0.475
2002 Mulligan C, Rochford J, Denyer G, Stephens R, Yeo G, Freeman T, Siddle K, O'Rahilly S. Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1. The Journal of Biological Chemistry. 277: 42480-7. PMID 12213819 DOI: 10.1074/Jbc.M206206200  0.475
2002 Crowley VE, Yeo GS, O'Rahilly S. Obesity therapy: altering the energy intake-and-expenditure balance sheet. Nature Reviews. Drug Discovery. 1: 276-86. PMID 12120279 DOI: 10.1038/Nrd770  0.544
2000 Challis BG, Yeo GS, Farooqi IS, Luan J, Aminian S, Halsall DJ, Keogh JM, Wareham NJ, O'Rahilly S. The CART gene and human obesity: mutational analysis and population genetics. Diabetes. 49: 872-5. PMID 10905499 DOI: 10.2337/Diabetes.49.5.872  0.531
2000 Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. The Journal of Clinical Investigation. 106: 271-9. PMID 10903343 DOI: 10.1172/Jci9397  0.577
2000 Yeo GS, Farooqi IS, Challis BG, Jackson RS, O'Rahilly S. The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models. Qjm : Monthly Journal of the Association of Physicians. 93: 7-14. PMID 10623776 DOI: 10.1093/Qjmed/93.1.7  0.545
1999 Elgar G, Clark MS, Meek S, Smith S, Warner S, Edwards YJ, Bouchireb N, Cottage A, Yeo GS, Umrania Y, Williams G, Brenner S. Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning. Genome Research. 9: 960-71. PMID 10523524 DOI: 10.1101/Gr.9.10.960  0.64
1998 Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genetics. 20: 111-2. PMID 9771698 DOI: 10.1038/2404  0.558
1997 Yeo GS, Elgar G, Sandford R, Brenner S. Cloning and sequencing of complement component C9 and its linkage to DOC-2 in the pufferfish Fugu rubripes. Gene. 200: 203-11. PMID 9373156 DOI: 10.1016/S0378-1119(97)00423-X  0.651
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