Gunnar Schulte - Publications

Affiliations: 
2002-2005 MBB Karolinska Institute, Stockholm, Sweden 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G. Structural insight into small molecule action on Frizzleds. Nature Communications. 11: 414. PMID 31964872 DOI: 10.1038/s41467-019-14149-3  0.44
2019 Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, Marti-Solano M, Rodríguez D, Hot B, Okashah N, Strakova K, Valnohova J, Babu MM, Lambert NA, Carlsson J, ... Schulte G, et al. A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. Nature Communications. 10: 667. PMID 30737406 DOI: 10.1038/s41467-019-08630-2  0.56
2018 Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C. FZD is a Gα-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science Signaling. 11. PMID 30514810 DOI: 10.1126/scisignal.aar5536  0.56
2018 Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnoš J, Bernatik O, Sri Ganji R, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G. Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization. The Journal of Biological Chemistry. PMID 30309985 DOI: 10.1074/jbc.RA118.004656  1
2018 Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G. Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment. The Journal of Biological Chemistry. PMID 30237173 DOI: 10.1074/jbc.RA118.004763  0.48
2017 Schulte G, Bryja V. WNT signalling: mechanisms and therapeutic opportunities. British Journal of Pharmacology. 174: 4543-4546. PMID 29235106 DOI: 10.1111/bph.14065  1
2017 Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, Friedler A, Strömqvist J, Wennmalm S, Carlsson J, Schulte G. Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling. Nature Communications. 8: 226. PMID 28790300 DOI: 10.1038/s41467-017-00253-9  0.56
2017 Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G. The tyrosine Y250(2.39) in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled. Cellular Signalling. PMID 28668722 DOI: 10.1016/j.cellsig.2017.06.018  1
2017 Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlén M, Kostenis E, Mulder J, Schulte G. FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis. Cellular Signalling. PMID 28126591 DOI: 10.1016/j.cellsig.2017.01.023  0.56
2016 Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, Hanakova K, Potesil D, Sedlackova M, Salasova A, Steinhart Z, Angers S, Schulte G, Hampl A, Zdrahal Z, et al. Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 27486244 DOI: 10.1073/pnas.1608783113  1
2016 Arthofer E, Hot B, Petersen J, Strakova K, Jager S, Grundmann M, Kostenis E, Gutkind SJ, Schulte G. WNT stimulation dissociates a Frizzled 4 inactive state complex with Gα12/13. Molecular Pharmacology. PMID 27458145 DOI: 10.1124/mol.116.104919  0.56
2016 Strömberg A, Olsson K, Dijksterhuis JP, Rullman E, Schulte G, Gustafsson T. CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 310: R297-304. PMID 26632602 DOI: 10.1152/ajpregu.00236.2015  0.6
2015 Dijksterhuis JP, Arthofer E, Marinescu VD, Nelander S, Uhlén M, Pontén F, Mulder J, Schulte G. High levels of WNT-5A in human glioma correlate with increased presence of tumour-associated microglia/monocytes. Experimental Cell Research. PMID 26511503 DOI: 10.1016/j.yexcr.2015.10.022  0.6
2015 Kaucká M, Petersen J, Janovská P, Radaszkiewicz T, Smy?ková L, Daulat AM, Borg JP, Schulte G, Bryja V. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway. Cell Communication and Signaling : Ccs. 13: 2. PMID 25627785 DOI: 10.1186/s12964-014-0079-1  0.96
2015 Dijksterhuis JP, Baljinnyam B, Stanger K, Sercan HO, Ji Y, Andres O, Rubin JS, Hannoush RN, Schulte G. Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs. The Journal of Biological Chemistry. 290: 6789-98. PMID 25605717 DOI: 10.1074/jbc.M114.612648  0.96
2014 Kilander MB, Dahlström J, Schulte G. Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cellular Signalling. 26: 1943-9. PMID 24873871 DOI: 10.1016/j.cellsig.2014.05.012  0.56
2014 Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G. Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2293-305. PMID 24500924 DOI: 10.1096/fj.13-246363  0.96
2014 Kríz V, Pospíchalová V, Masek J, Kilander MB, Slavík J, Tanneberger K, Schulte G, Machala M, Kozubík A, Behrens J, Bryja V. β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein. The Journal of Biological Chemistry. 289: 1128-41. PMID 24265322 DOI: 10.1074/jbc.M113.498444  1
2013 Halleskog C, Schulte G. WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia. Journal of Neurochemistry. 125: 803-8. PMID 23534675 DOI: 10.1111/jnc.12250  0.4
2013 Halleskog C, Schulte G. Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A. Cellular Signalling. 25: 822-8. PMID 23266471 DOI: 10.1016/j.cellsig.2012.12.006  0.4
2012 Halleskog C, Dijksterhuis JP, Kilander MB, Becerril-Ortega J, Villaescusa JC, Lindgren E, Arenas E, Schulte G. Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. Journal of Neuroinflammation. 9: 111. PMID 22647544 DOI: 10.1186/1742-2094-9-111  0.96
2011 Fröjmark AS, Schuster J, Sobol M, Entesarian M, Kilander MB, Gabrikova D, Nawaz S, Baig SM, Schulte G, Klar J, Dahl N. Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. American Journal of Human Genetics. 88: 852-60. PMID 21665003 DOI: 10.1016/j.ajhg.2011.05.013  0.56
2011 Mulder J, Zilberter M, Pasquaré SJ, Alpár A, Schulte G, Ferreira SG, Köfalvi A, Martín-Moreno AM, Keimpema E, Tanila H, Watanabe M, Mackie K, Hortobágyi T, de Ceballos ML, Harkany T. Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. Brain : a Journal of Neurology. 134: 1041-60. PMID 21459826 DOI: 10.1093/brain/awr046  0.96
2011 Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J. Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation. The Embo Journal. 30: 1433-43. PMID 21304492 DOI: 10.1038/emboj.2011.28  1
2011 Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V. Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases. The Journal of Biological Chemistry. 286: 10396-410. PMID 21285348 DOI: 10.1074/jbc.M110.169870  1
2011 Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G. WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins. Cellular Signalling. 23: 550-4. PMID 21070854 DOI: 10.1016/j.cellsig.2010.11.004  1
2011 Červenka I, Wolf J, Mašek J, Krejci P, Wilcox WR, Kozubík A, Schulte G, Gutkind JS, Bryja V. Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6. Molecular and Cellular Biology. 31: 179-89. PMID 20974802 DOI: 10.1128/MCB.00550-10  1
2011 Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobágyi T, Tanila H, Kumar Puli L, Färber K, Harkany T, Schulte G. WNT signaling in activated microglia is proinflammatory. Glia. 59: 119-31. PMID 20967887 DOI: 10.1002/glia.21081  0.96
2010 Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T. Vang-like protein 2 and Rac1 interact to regulate adherens junctions. Journal of Cell Science. 123: 472-83. PMID 20067994 DOI: 10.1242/jcs.048074  0.96
2010 Schulte G, Schambony A, Bryja V. beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? British Journal of Pharmacology. 159: 1051-8. PMID 19888962 DOI: 10.1111/j.1476-5381.2009.00466.x  1
2008 Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G. Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. Embo Reports. 9: 1244-50. PMID 18953287 DOI: 10.1038/embor.2008.193  0.96
2008 Brand F, Klutz AM, Jacobson KA, Fredholm BB, Schulte G. Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC. European Journal of Pharmacology. 590: 36-42. PMID 18603240 DOI: 10.1016/j.ejphar.2008.05.036  0.96
2007 Schulte G, Bryja V. The Frizzled family of unconventional G-protein-coupled receptors. Trends in Pharmacological Sciences. 28: 518-25. PMID 17884187 DOI: 10.1016/j.tips.2007.09.001  1
2007 Daré E, Schulte G, Karovic O, Hammarberg C, Fredholm BB. Modulation of glial cell functions by adenosine receptors. Physiology & Behavior. 92: 15-20. PMID 17574632 DOI: 10.1016/j.physbeh.2007.05.031  0.96
2007 Schulte G, Fredholm B. A Nordic meeting on G-protein-coupled receptors: From molecular aspects to novel therapy Acta Physiologica. 190: 1. PMID 17428226 DOI: 10.1111/j.1365-201X.2007.01686.x  0.96
2007 Bryja V, Gradl D, Schambony A, Arenas E, Schulte G. Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 6690-5. PMID 17426148 DOI: 10.1073/pnas.0611356104  0.96
2007 Bryja V, Schulte G, Rawal N, Grahn A, Arenas E. Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. Journal of Cell Science. 120: 586-95. PMID 17244647 DOI: 10.1242/jcs.03368  0.96
2007 Bryja V, Schulte G, Arenas E. Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cellular Signalling. 19: 610-6. PMID 17027228 DOI: 10.1016/j.cellsig.2006.08.011  0.96
2005 Berghuis P, Dobszay MB, Wang X, Spano S, Ledda F, Sousa KM, Schulte G, Ernfors P, Mackie K, Paratcha G, Hurd YL, Harkany T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 19115-20. PMID 16357196 DOI: 10.1073/pnas.0509494102  0.96
2005 Schulte G, Bryja V, Rawal N, Castelo-Branco G, Sousa KM, Arenas E. Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. Journal of Neurochemistry. 92: 1550-3. PMID 15748172 DOI: 10.1111/j.1471-4159.2004.03022.x  0.96
2004 Schulte G, Sommerschild H, Yang J, Tokuno S, Goiny M, Lövdahl C, Johansson B, Fredholm BB, Valen G. Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia. Acta Physiologica Scandinavica. 182: 133-43. PMID 15450109 DOI: 10.1111/j.1365-201X.2004.01350.x  0.96
2004 Berghuis P, Dobszay MB, Sousa KM, Schulte G, Mager PP, Härtig W, Görcs TJ, Zilberter Y, Ernfors P, Harkany T. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons. The European Journal of Neuroscience. 20: 1290-306. PMID 15341601 DOI: 10.1111/j.1460-9568.2004.03561.x  0.96
2004 Harkany T, Holmgren C, Härtig W, Qureshi T, Chaudhry FA, Storm-Mathisen J, Dobszay MB, Berghuis P, Schulte G, Sousa KM, Fremeau RT, Edwards RH, Mackie K, Ernfors P, Zilberter Y. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4978-88. PMID 15163690 DOI: 10.1523/JNEUROSCI.4884-03.2004  0.96
2004 Hammarberg C, Fredholm BB, Schulte G. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase. Biochemical Pharmacology. 67: 129-34. PMID 14667935  0.92
2004 Hammarberg C, Fredholm BB, Schulte G. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3′-kinase Biochemical Pharmacology. 67: 129-134. DOI: 10.1016/j.bcp.2003.08.031  0.96
2003 Schulte G, Fredholm BB. The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38. Experimental Cell Research. 290: 168-76. PMID 14516797 DOI: 10.1016/S0014-4827(03)00324-0  0.96
2003 Hammarberg C, Schulte G, Fredholm BB. Evidence for functional adenosine A3 receptors in microglia cells. Journal of Neurochemistry. 86: 1051-4. PMID 12887702 DOI: 10.1046/j.1471-4159.2003.01919.x  0.96
2003 Lynge J, Schulte G, Nordsborg N, Fredholm BB, Hellsten Y. Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells. Biochemical and Biophysical Research Communications. 307: 180-7. PMID 12849998 DOI: 10.1016/S0006-291X(03)01125-2  0.96
2003 Schulte G, Fredholm BB. Signalling from adenosine receptors to mitogen-activated protein kinases. Cellular Signalling. 15: 813-27. PMID 12834807 DOI: 10.1016/S0898-6568(03)00058-5  0.96
2003 Fredholm BB, Halldner L, Johansson C, Schulte G, Lövdahl C, Thorén P, Dunwiddie TV, Masino SA, Poelchen W, Diao L, Illes P, Zahniser NR, Valen G, Tokuno S, Sommerschild H, et al. Consequences of eliminating adenosine A1 receptors in mice Drug Development Research. 58: 350-353. DOI: 10.1002/ddr.10170  0.96
2002 Schulte G, Fredholm BB. Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2. Molecular Pharmacology. 62: 1137-46. PMID 12391277 DOI: 10.1124/mol.62.5.1137  0.96
2002 Schulte G, Fredholm BB. Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists. Cellular Signalling. 14: 109-13. PMID 11781134 DOI: 10.1016/S0898-6568(01)00228-5  0.96
2001 Fredholm BB, Irenius E, Kull B, Schulte G. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochemical Pharmacology. 61: 443-8. PMID 11226378 DOI: 10.1016/S0006-2952(00)00570-0  0.96
2001 Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Ådén U, Svenningsson P. Adenosine receptor signaling in vitro and in vivo Drug Development Research. 52: 274-282. DOI: 10.1002/ddr.1124  0.96
2000 Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn-Schmiedeberg's Archives of Pharmacology. 362: 364-74. PMID 11111830 DOI: 10.1007/s002100000313  0.96
1999 Robertson B, Schulte G, Elde R, Grant G. Effects of sciatic nerve injuries on δ-opioid receptor and substance P immunoreactivities in the superficial dorsal horn of the rat European Journal of Pain. 3: 115-129. DOI: 10.1053/eujp.1998.0104  0.96
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