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Hao Wu - Publications

Affiliations: 
Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
Area:
structural immunology
Website:
http://www.fas.harvard.edu/~biophys/Hao_Wu.htm
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Year Citation  Score
2024 Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, ... ... Wu H, et al. ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature. PMID 38599239 DOI: 10.1038/s41586-024-07373-5  0.346
2024 Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, ... ... Wu H, et al. The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science Immunology. eadn1452. PMID 38530158 DOI: 10.1126/sciimmunol.adn1452  0.316
2024 Fu J, Schroder K, Wu H. Mechanistic insights from inflammasome structures. Nature Reviews. Immunology. PMID 38374299 DOI: 10.1038/s41577-024-00995-w  0.374
2024 Li R, Zan Y, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C, Wu H, Zhu S. A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321419121. PMID 38289959 DOI: 10.1073/pnas.2321419121  0.305
2023 Paidimuddala B, Cao J, Nash G, Xie Q, Wu H, Zhang L. Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature Structural & Molecular Biology. PMID 36604500 DOI: 10.1038/s41594-022-00889-2  0.316
2022 Fu J, Wu H. Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation. Annual Review of Immunology. PMID 36750315 DOI: 10.1146/annurev-immunol-081022-021207  0.325
2022 Xiao L, Magupalli VG, Wu H. Cryo-EM structures of the active NLRP3 inflammasome disk. Nature. PMID 36442502 DOI: 10.1038/s41586-022-05570-8  0.326
2022 Fontana P, Dong Y, Pi X, Tong AB, Hecksel CW, Wang L, Fu TM, Bustamante C, Wu H. Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold. Science (New York, N.Y.). 376: eabm9326. PMID 35679401 DOI: 10.1126/science.abm9326  0.689
2022 Zheng W, Shen C, Wang L, Rawson S, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H, Fu TM. pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Science Advances. 8: eabm1568. PMID 35333573 DOI: 10.1126/sciadv.abm1568  0.641
2022 Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, et al. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. PMID 35259335 DOI: 10.1016/j.cell.2022.02.002  0.685
2022 Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35149555 DOI: 10.1073/pnas.2117198119  0.671
2021 Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. PMID 34678144 DOI: 10.1016/j.cell.2021.09.032  0.694
2021 Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, ... ... Wu H, et al. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death and Differentiation. PMID 34511601 DOI: 10.1038/s41418-021-00867-z  0.645
2021 Yang Q, Li J, Zhang Z, Wu X, Liao T, Yu S, You Z, Hou X, Ye J, Liu G, Ma S, Xie G, Zhou Y, Li M, Wu M, ... ... Wu H, ... ... Wu H, et al. Clinical characteristics and a decision tree model to predict death outcome in severe COVID-19 patients. Bmc Infectious Diseases. 21: 783. PMID 34372767 DOI: 10.1186/s12879-021-06478-w  0.558
2021 Zhou Y, Yang Q, Ye J, Wu X, Hou X, Feng Y, Luo B, Li J, Yang G, Li L, Yang X, Wang B, Zhao S, Li L, Li Q, ... ... Wu H, et al. Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study. Bmc Infectious Diseases. 21: 760. PMID 34353293 DOI: 10.1186/s12879-021-06495-9  0.555
2021 Zhu L, Xie H, Liu Q, Ma F, Wu H. Klotho inhibits H O -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression. Clinical and Experimental Pharmacology & Physiology. PMID 34174105 DOI: 10.1111/1440-1681.13547  0.379
2021 Zhu L, Xie H, Liu Q, Ma F, Wu H. Klotho inhibits H O -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression. Clinical and Experimental Pharmacology & Physiology. PMID 34174105 DOI: 10.1111/1440-1681.13547  0.379
2021 Wang L, Sharif H, Vora SM, Zheng Y, Wu H. Structures and functions of the inflammasome engine. The Journal of Allergy and Clinical Immunology. 147: 2021-2029. PMID 34092352 DOI: 10.1016/j.jaci.2021.04.018  0.553
2021 Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H. Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity. PMID 34019797 DOI: 10.1016/j.immuni.2021.04.024  0.562
2021 Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. PMID 33883744 DOI: 10.1038/s41586-021-03478-3  0.775
2021 Guo JC, Xie H, Wu H, Tong TJ. [Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis]. Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology. 39: 195-202. PMID 33834675 DOI: 10.7518/hxkq.2021.02.011  0.316
2021 Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H. DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature. PMID 33731932 DOI: 10.1038/s41586-021-03350-4  0.584
2021 Wang L, Chen Z, Wu H, Fu TM. Purification and cryoelectron microscopy structure determination of human V-ATPase. Star Protocols. 2: 100350. PMID 33665630 DOI: 10.1016/j.xpro.2021.100350  0.66
2021 Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature Communications. 12: 189. PMID 33420033 DOI: 10.1038/s41467-020-20320-y  0.799
2020 Guo J, Xie H, Wu H, Liang M. Efficacy of Lycopene in the Treatment of Oral Submucous Fibrosis: A Meta-analysis of Randomized Controlled Trials. The Journal of Evidence-Based Dental Practice. 20: 101471. PMID 33303091 DOI: 10.1016/j.jebdp.2020.101471  0.312
2020 Guo J, Xie H, Wu H. Preventive Measures for COVID-19 in Dental Treatments. Disaster Medicine and Public Health Preparedness. 1-13. PMID 33092676 DOI: 10.1017/dmp.2020.409  0.315
2020 Wang L, Wu D, Robinson CV, Wu H, Fu TM. Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Molecular Cell. PMID 33065002 DOI: 10.1016/j.molcel.2020.09.029  0.675
2020 Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. Biorxiv : the Preprint Server For Biology. PMID 32995777 DOI: 10.1101/2020.09.18.302901  0.668
2020 Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, ... ... Wu H, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science (New York, N.Y.). 369. PMID 32943500 DOI: 10.1126/Science.Aas8995  0.799
2020 Zang Z, Lv Y, Liu S, Yang W, Ci J, Ren X, Wang Z, Wu H, Ma W, Jiang L, Yang W. A Novel ERF Transcription Factor, , Positively Regulates Maize Resistance to . Frontiers in Plant Science. 11: 850. PMID 32612628 DOI: 10.3389/fpls.2020.00850  0.317
2020 Guo J, Xie H, Liang M, Wu H. COVID-19: a novel coronavirus and a novel challenge for oral healthcare. Clinical Oral Investigations. PMID 32382932 DOI: 10.1007/s00784-020-03291-8  0.309
2020 Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, ... ... Wu H, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunology. PMID 32367036 DOI: 10.1038/S41590-020-0669-6  0.709
2020 Sadek J, Wuo MG, Rooklin D, Hauenstein A, Hong SH, Gautam A, Wu H, Zhang Y, Cesarman E, Arora PS. Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nature Communications. 11: 1786. PMID 32286300 DOI: 10.1038/S41467-020-15576-3  0.793
2020 Guo J, Xie H, Mao S, Liang M, Wu H. Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: a meta-analysis of randomised controlled clinical trials. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. PMID 32145110 DOI: 10.1111/jop.13009  0.316
2019 Xia S, Ruan J, Wu H. Monitoring gasdermin pore formation in vitro. Methods in Enzymology. 625: 95-107. PMID 31455540 DOI: 10.1016/bs.mie.2019.04.024  0.731
2019 Xia S, Hollingsworth LR, Wu H. Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harbor Perspectives in Biology. PMID 31451512 DOI: 10.1101/cshperspect.a036400  0.312
2019 Wu H, Arnold E. Michael G. Rossmann (1930-2019). Nature Structural & Molecular Biology. PMID 31285606 DOI: 10.1038/S41594-019-0271-5  0.395
2019 Xie H, Guo J, Tan B, Wu H. Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis: A meta-analysis of randomized controlled trials. Medicine. 98: e16339. PMID 31277186 DOI: 10.1097/MD.0000000000016339  0.316
2019 Arnold E, Wu H, Johnson JE. Michael G. Rossmann (1930-2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend. Acta Crystallographica. Section D, Structural Biology. 75: 523-527. PMID 31205014 DOI: 10.1107/S2059798319008398  0.587
2019 Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. PMID 31189953 DOI: 10.1038/S41586-019-1295-Z  0.808
2019 Xia S, Wang L, Fu TM, Wu H. Mechanism of TRPM2 channel gating revealed by cryo-EM. The Febs Journal. PMID 31144442 DOI: 10.1111/febs.14939  0.67
2019 Shen C, Sharif H, Xia S, Wu H. Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Current Opinion in Structural Biology. 58: 18-25. PMID 31128494 DOI: 10.1016/J.Sbi.2019.03.033  0.557
2019 Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, ... Wu H, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.). 364. PMID 31097636 DOI: 10.1126/Science.Aau0159  0.67
2019 Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature Immunology. PMID 30846880 DOI: 10.1038/s41590-019-0361-x  0.66
2019 Pan L, Fu TM, Zhao W, Zhao L, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H, Chou JJ. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell. PMID 30827683 DOI: 10.1016/j.cell.2019.02.001  0.693
2019 Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature Immunology. PMID 30692621 DOI: 10.1038/s41590-018-0303-z  0.728
2019 Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674671 DOI: 10.2210/Pdb6Ndj/Pdb  0.813
2018 Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H. Structures and gating mechanism of human TRPM2. Science (New York, N.Y.). PMID 30467180 DOI: 10.1126/Science.Aav4809  0.674
2018 Luong PH, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 7. PMID 30355448 DOI: 10.7554/Elife.38539  0.692
2018 Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30279182 DOI: 10.1073/pnas.1810524115  0.82
2018 Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. PMID 29695864 DOI: 10.1038/s41586-018-0058-6  0.705
2018 Mompeán M, Li W, Li J, Laage S, Siemer AB, Bozkurt G, Wu H, McDermott AE. The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex. Cell. PMID 29681455 DOI: 10.1016/J.Cell.2018.03.032  0.634
2018 Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Molecular Cell. 69: 566-580.e5. PMID 29452637 DOI: 10.1016/J.Molcel.2018.01.027  0.71
2018 Xia S, Fu TM, Wu H. Inflammation NODs to Antagonists of RIP2-XIAP Interaction. Molecular Cell. 69: 535-536. PMID 29452633 DOI: 10.1016/j.molcel.2018.02.003  0.683
2018 Fu TM, Shen C, Li Q, Zhang P, Wu H. Mechanism of ubiquitin transfer promoted by TRAF6. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432170 DOI: 10.1073/pnas.1721788115  0.692
2018 David L, Li Y, Ma J, Garner E, Zhang X, Wu H. Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proceedings of the National Academy of Sciences of the United States of America. PMID 29382759 DOI: 10.1073/pnas.1721967115  0.329
2017 Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. PMID 29195811 DOI: 10.1016/J.Immuni.2017.11.013  0.695
2017 Hauenstein AV, Xu G, Kabaleeswaran V, Wu H. Evidence for M1-linked Polyubiquitin-Mediated Conformational Change in NEMO. Journal of Molecular Biology. PMID 29111346 DOI: 10.1016/J.Jmb.2017.10.026  0.793
2017 Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. Immunity. 47: 635-647.e6. PMID 29045898 DOI: 10.1016/J.Immuni.2017.09.011  0.643
2017 Sharif H, Li Y, Dong Y, Dong L, Wang WL, Mao Y, Wu H. Cryo-EM structure of the DNA-PK holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652322 DOI: 10.1073/Pnas.1707386114  0.498
2017 Lamour G, Nassar R, Chan PH, Bozkurt G, Li J, Bui JM, Yip CK, Mayor T, Li H, Wu H, Gsponer JA. Mapping the Broad Structural and Mechanical Properties of Amyloid Fibrils. Biophysical Journal. 112: 584-594. PMID 28256219 DOI: 10.1016/J.Bpj.2016.12.036  0.592
2016 Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H. Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Molecular Cell. PMID 27746017 DOI: 10.1016/J.Molcel.2016.09.009  0.729
2016 Wang H, Horbinski C, Wu H, Liu Y, Sheng S, Liu J, Weiss H, Stromberg AJ, Wang C. NanoStringDiff: a novel statistical method for differential expression analysis based on NanoString nCounter data. Nucleic Acids Research. PMID 27471031 DOI: 10.1093/Nar/Gkw677  0.498
2016 Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 535: 153-158. PMID 27383986 DOI: 10.1038/Nature18629  0.718
2016 Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science (New York, N.Y.). PMID 27103670 DOI: 10.1126/Science.Aaf3036  0.715
2016 Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. The Journal of Experimental Medicine. PMID 27069117 DOI: 10.1084/Jem.20151790  0.734
2016 Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nature Structural & Molecular Biology. PMID 27043298 DOI: 10.1038/Nsmb.3199  0.804
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Wu H, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882  0.497
2016 Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ. Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Molecular Cell. PMID 26853147 DOI: 10.1016/J.Molcel.2016.01.009  0.718
2015 Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discovery. 1. PMID 26583071 DOI: 10.1038/celldisc.2015.13  0.768
2015 Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H. Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. PMID 26548953 DOI: 10.1016/J.Cell.2015.10.055  0.675
2015 Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ. The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. The Journal of Biological Chemistry. PMID 26468282 DOI: 10.1074/jbc.M115.687731  0.302
2015 Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science (New York, N.Y.). PMID 26449474 DOI: 10.1126/science.aac5789  0.793
2015 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 11: 741. PMID 26284675 DOI: 10.1038/Nchembio0915-741C  0.462
2015 Hauenstein AV, Zhang L, Wu H. The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines. Current Opinion in Structural Biology. 31: 75-83. PMID 25881155 DOI: 10.1016/J.Sbi.2015.03.014  0.813
2015 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 11: 235. PMID 25689338 DOI: 10.1038/Nchembio0315-235D  0.465
2015 Chen L, Wang C, Qin ZS, Wu H. A novel statistical method for quantitative comparison of multiple ChIP-seq datasets. Bioinformatics (Oxford, England). 31: 1889-96. PMID 25682068 DOI: 10.1093/bioinformatics/btv094  0.508
2015 Yin Q, Fu TM, Li J, Wu H. Structural biology of innate immunity. Annual Review of Immunology. 33: 393-416. PMID 25622194 DOI: 10.1146/Annurev-Immunol-032414-112258  0.799
2015 Lu A, Wu H. Structural mechanisms of inflammasome assembly Febs Journal. 282: 435-444. PMID 25354325 DOI: 10.1111/febs.13133  0.331
2015 Wu H, Wang C, Wu Z. PROPER: comprehensive power evaluation for differential expression using RNA-seq. Bioinformatics (Oxford, England). 31: 233-41. PMID 25273110 DOI: 10.1093/Bioinformatics/Btu640  0.488
2014 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 10: 1043-8. PMID 25344812 DOI: 10.1038/Nchembio.1661  0.54
2014 Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH. Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitment. Biochemistry. 53: 5424-31. PMID 25119434 DOI: 10.1021/Bi500585U  0.664
2014 Wu H, Williams J, Nathans J. Complete morphologies of basal forebrain cholinergic neurons in the mouse. Elife. 3: e02444. PMID 24894464 DOI: 10.7554/Elife.02444  0.391
2014 Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 156: 1193-206. PMID 24630722 DOI: 10.1016/J.Cell.2014.02.008  0.786
2014 Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H. Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of its Self-association to DED/DED Interactions Journal of Molecular Biology. 426: 1420-1427. PMID 24406744 DOI: 10.1016/J.Jmb.2013.12.029  0.72
2013 Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Molecular Cell. 51: 766-79. PMID 24074955 DOI: 10.1016/J.Molcel.2013.08.032  0.325
2013 Li J, Yin Q, Wu H. Structural basis of signal transduction in the TNF receptor superfamily. Advances in Immunology. 119: 135-53. PMID 23886067 DOI: 10.1016/B978-0-12-407707-2.00005-9  0.721
2013 Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Cell Reports. 4: 327-39. PMID 23850291 DOI: 10.1016/J.Celrep.2013.06.024  0.579
2013 Lee JH, Yi L, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H. Crystal structure and versatile functional roles of the COP9 signalosome subunit 1. Proceedings of the National Academy of Sciences of the United States of America. 110: 11845-50. PMID 23818606 DOI: 10.1073/Pnas.1302418110  0.651
2013 Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ. Anticancer flavonoids are mouse-selective STING agonists. Acs Chemical Biology. 8: 1396-401. PMID 23683494 DOI: 10.1021/Cb400264N  0.554
2013 Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A. Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 38: 896-905. PMID 23602765 DOI: 10.1016/J.Immuni.2013.03.008  0.507
2013 Wu H, Wang C, Wu Z. A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data. Biostatistics (Oxford, England). 14: 232-43. PMID 23001152 DOI: 10.1093/Biostatistics/Kxs033  0.494
2012 Wu H, Williams J, Nathans J. Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling. Elife. 1: e00181. PMID 23256042 DOI: 10.7554/Elife.00181  0.416
2012 Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150: 339-50. PMID 22817896 DOI: 10.1016/J.Cell.2012.06.019  0.627
2012 Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H. Cyclic di-GMP sensing via the innate immune signaling protein STING. Molecular Cell. 46: 735-45. PMID 22705373 DOI: 10.1016/J.Molcel.2012.05.029  0.679
2012 Ferrao R, Li J, Bergamin E, Wu H. Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Science Signaling. 5: re3. PMID 22649099 DOI: 10.1126/Scisignal.2003124  0.634
2011 Wu H, Lo YC, Yin Q. Structural studies of NEMO and TRAF6: implications in NF-κB activation. Advances in Experimental Medicine and Biology. 691: 89-91. PMID 21153312 DOI: 10.1007/978-1-4419-6612-4_9  0.554
2011 Zheng C, Yin Q, Wu H. Structural studies of NF-κB signaling. Cell Research. 21: 183-95. PMID 21135870 DOI: 10.1038/cr.2010.171  0.548
2010 Wang L, Yang JK, Kabaleeswaran V, Rice AJ, Cruz AC, Park AY, Yin Q, Damko E, Jang SB, Raunser S, Robinson CV, Siegel RM, Walz T, Wu H. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nature Structural & Molecular Biology. 17: 1324-9. PMID 20935634 DOI: 10.1038/Nsmb.1920  0.59
2009 Yin Q, Lamothe B, Darnay BG, Wu H. Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry. 48: 10558-67. PMID 19810754 DOI: 10.1021/bi901462e  0.607
2009 Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich RL, Campos AD, Myszka DG, Lenardo MJ, Darnay BG, Wu H. E2 interaction and dimerization in the crystal structure of TRAF6. Nature Structural & Molecular Biology. 16: 658-66. PMID 19465916 DOI: 10.1038/nsmb.1605  0.564
2009 Wang R, Wei Z, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen Z, Zhang M. Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor. Molecular Cell. 33: 692-703. PMID 19328064 DOI: 10.1016/J.Molcel.2009.02.016  0.305
2009 Pan W, da Graca LS, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. The Journal of Biological Chemistry. 284: 6946-54. PMID 19121999 DOI: 10.1074/Jbc.M805801200  0.578
2007 Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li YM, Jiang X. A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo. The Journal of Biological Chemistry. 282: 30718-27. PMID 17724022 DOI: 10.1074/Jbc.M705258200  0.588
2007 Lin SC, Huang Y, Lo YC, Lu M, Wu H. Crystal structure of the BIR1 domain of XIAP in two crystal forms. Journal of Molecular Biology. 372: 847-54. PMID 17698078 DOI: 10.1016/J.Jmb.2007.07.019  0.623
2007 Chung JY, Lu M, Yin Q, Lin SC, Wu H. Molecular basis for the unique specificity of TRAF6. Advances in Experimental Medicine and Biology. 597: 122-30. PMID 17633022 DOI: 10.1007/978-0-387-70630-6_10  0.551
2007 Chung JY, Lu M, Yin Q, Wu H. Structural revelations of TRAF2 function in TNF receptor signaling pathway. Advances in Experimental Medicine and Biology. 597: 93-113. PMID 17633020 DOI: 10.1007/978-0-387-70630-6_8  0.596
2007 Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H. XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Molecular Cell. 26: 689-702. PMID 17560374 DOI: 10.1016/J.Molcel.2007.05.006  0.621
2006 Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS, Jiang X, Wu H. Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Molecular Cell. 22: 259-68. PMID 16630893 DOI: 10.1016/j.molcel.2006.03.030  0.574
2006 Park HH, Wu H. Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly Journal of Molecular Biology. 357: 358-364. PMID 16434054 DOI: 10.1016/j.jmb.2005.12.082  0.317
2005 Yang JK, Wang L, Zheng L, Wan F, Ahmed M, Lenardo MJ, Wu H. Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Molecular Cell. 20: 939-49. PMID 16364918 DOI: 10.1016/j.molcel.2005.10.023  0.312
2004 Wu H. Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily Advances in Protein Chemistry. 68: 225-279. PMID 15500863 DOI: 10.1016/S0065-3233(04)68007-7  0.303
2004 Huang Y, Lu M, Wu H. Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers? Cancer Cell. 5: 1-2. PMID 14749118 DOI: 10.1016/S1535-6108(03)00340-4  0.593
2003 Huang Y, Rich RL, Myszka DG, Wu H. Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. The Journal of Biological Chemistry. 278: 49517-22. PMID 14512414 DOI: 10.1074/Jbc.M310061200  0.618
2003 Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H. Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35. The Journal of Biological Chemistry. 278: 5455-61. PMID 12458208 DOI: 10.1074/Jbc.M211607200  0.6
2002 Moldovan MC, Yachou A, Lévesque K, Wu H, Hendrickson WA, Cohen EA, Sékaly RP. CD4 dimers constitute the functional component required for T cell activation Journal of Immunology. 169: 6261-6268. PMID 12444132 DOI: 10.4049/Jimmunol.169.11.6261  0.478
2001 Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature. 410: 494-7. PMID 11260720 DOI: 10.1038/35068604  0.585
2001 Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H. Structural Basis of Caspase Inhibition by XIAP Cell. 104: 781-790. DOI: 10.1016/S0092-8674(01)00273-2  0.597
1997 Wu H, Kwong PD, Hendrickson WA. Dimeric association and segmental variability in the structure of human CD4. Nature. 387: 527-30. PMID 9168119 DOI: 10.1038/387527A0  0.473
Low-probability matches (unlikely to be authored by this person)
2014 Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H. IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly. Molecular Cell. 55: 891-903. PMID 25201411 DOI: 10.1016/J.Molcel.2014.08.006  0.3
2007 Park HH, Logette E, Raunser S, Cuenin S, Walz T, Tschopp J, Wu H. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 128: 533-46. PMID 17289572 DOI: 10.1016/J.Cell.2007.01.019  0.299
2012 Ferrao R, Wu H. Helical assembly in the death domain (DD) superfamily Current Opinion in Structural Biology. 22: 241-247. PMID 22429337 DOI: 10.1016/J.Sbi.2012.02.006  0.299
2021 Andreeva L, David L, Rawson S, Shen C, Pasricha T, Pelegrin P, Wu H. NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell. PMID 34861190 DOI: 10.1016/j.cell.2021.11.011  0.298
2023 Du G, Healy LB, David L, Walker C, Fontana P, Dong Y, Devant P, Puthenveetil R, Ficarro SB, Banerjee A, Kagan JC, Lieberman J, Wu H. ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation. Biorxiv : the Preprint Server For Biology. PMID 36945424 DOI: 10.1101/2023.03.07.531538  0.298
2007 Feng W, Huang S, Wu H, Zhang M. Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. Journal of Molecular Biology. 372: 223-35. PMID 17659302 DOI: 10.1016/J.Jmb.2007.06.069  0.297
2021 Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, et al. NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Frontiers in Immunology. 12: 683803. PMID 34122445 DOI: 10.3389/fimmu.2021.683803  0.296
2017 Yan F, Wang S, Yang W, Goldberg SN, Wu H, Duan WL, Deng ZT, Han HB, Zheng HR. Tumor-penetrating Peptide-integrated Thermally Sensitive Liposomal Doxorubicin Enhances Efficacy of Radiofrequency Ablation in Liver Tumors. Radiology. 162405. PMID 28631963 DOI: 10.1148/Radiol.2017162405  0.295
2010 Jang TH, Zheng C, Wu H, Jeon JH, Park HH. In vitro reconstitution of the interactions in the PIDDosome Apoptosis. 15: 1444-1452. PMID 20872280 DOI: 10.1007/s10495-010-0544-2  0.294
2020 Wu H, Li SS, Zhou M, Jiang AN, He Y, Wang S, Yang W, Liu H. Palliative Radiofrequency Ablation Accelerates the Residual Tumor Progression Through Increasing Tumor-Infiltrating MDSCs and Reducing T-Cell-Mediated Anti-Tumor Immune Responses in Animal Model. Frontiers in Oncology. 10: 1308. PMID 33014771 DOI: 10.3389/fonc.2020.01308  0.293
2018 Wang W, Mao S, Yu H, Wu H, Shan X, Zhang X, Cui G, Liu X. Pinellia pedatisecta lectin exerts a proinflammatory activity correlated with ROS-MAPKs/NF-κB pathways and the NLRP3 inflammasome in RAW264.7 cells accompanied by cell pyroptosis. International Immunopharmacology. 66: 1-12. PMID 30415189 DOI: 10.1016/j.intimp.2018.11.002  0.293
2007 Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. The Journal of Biological Chemistry. 282: 4102-12. PMID 17135271 DOI: 10.1074/jbc.M609503200  0.293
2007 Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. The Journal of Biological Chemistry. 282: 3918-28. PMID 17158449 DOI: 10.1074/jbc.M608867200  0.291
2019 Wang L, Ferrao R, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). The Journal of Biological Chemistry. PMID 30679311 DOI: 10.1074/Jbc.Ra118.005428  0.29
2024 Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. Host E3 ubiquitin ligase ITCH mediates effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Mbio. e0330223. PMID 38376248 DOI: 10.1128/mbio.03302-23  0.289
2019 Wu H, Castenheira P, Faro C, Tang J. Cardosin A Endocytosis Mediated by Integrin Leads to Lysosome Leakage and Apoptosis of Epithelial Cells. Proteins. PMID 30785216 DOI: 10.1002/Prot.25672  0.287
2018 Feltham R, Jamal K, Tenev T, Liccardi G, Jaco I, Domingues CM, Morris O, John SW, Annibaldi A, Widya M, Kearney CJ, Clancy D, Elliott PR, Glatter T, Qiao Q, ... Wu H, et al. Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. Cell Reports. 23: 470-484. PMID 29642005 DOI: 10.1016/J.Celrep.2018.03.054  0.286
2020 Wang L, Negro R, Wu H. TRPM2, linking oxidative stress and Ca permeation to NLRP3 inflammasome activation. Current Opinion in Immunology. 62: 131-135. PMID 32058297 DOI: 10.1016/j.coi.2020.01.005  0.286
2024 Du L, Chen C, Yang YH, Zheng Y, Li H, Wu ZJ, Wu H, Miyashita K, Su GH. Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice. Food & Function. PMID 38787699 DOI: 10.1039/d4fo00611a  0.286
2022 Tang L, Dong S, Rasheed N, Wu HW, Zhou N, Li H, Wang M, Zheng J, He J, Chao WCH. Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP. Cell Reports. 41: 111732. PMID 36476863 DOI: 10.1016/j.celrep.2022.111732  0.286
2024 Lu Y, Zhu D, Hu B, Chen R, Wang X, Xu X, Wang W, Wu H, Wang Y. pH-Responsive, Self-Assembled Ruthenium Nanodrug: Dual Impact on Lysosomes and DNA for Synergistic Chemotherapy and Immunogenic Cell Death. Small (Weinheim An Der Bergstrasse, Germany). e2310636. PMID 38412413 DOI: 10.1002/smll.202310636  0.285
2013 Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2132-44. PMID 23430844 DOI: 10.1096/Fj.12-214353  0.284
2018 Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, et al. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science (New York, N.Y.). PMID 30361383 DOI: 10.1126/science.aau2818  0.284
2024 Wang L, Sun F, Li Q, Ma H, Zhong J, Zhang H, Cheng S, Wu H, Zhao Y, Wang N, Xie Z, Zhao M, Zhu P, Zheng H. CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors. Communications Biology. 7: 630. PMID 38789577 DOI: 10.1038/s42003-024-06289-0  0.283
2022 Wang S, Liu J, Wu H, Jiang A, Zhao K, Yan K, Wu W, Han H, Zhang Y, Yang W. All-trans retinoic acid (ATRA) inhibits insufficient radiofrequency ablation (IRFA)-induced enrichment of tumor-initiating cells in hepatocellular carcinoma. Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu. 33: 694-707. PMID 35125813 DOI: 10.21147/j.issn.1000-9604.2021.06.06  0.282
2007 Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H. The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annual Review of Immunology. 25: 561-86. PMID 17201679 DOI: 10.1146/annurev.immunol.25.022106.141656  0.282
2023 Li G, Song Z, Ru Y, Zhang J, Luo L, Yang W, Wu H, Jin H, Bao X, Wei D, Yan Z, Qu H, Zhu Z, Xue X, Zhou G. Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment. Exploration (Beijing, China). 3: 20220141. PMID 37933289 DOI: 10.1002/EXP.20220141  0.281
2007 Park HH, Wu H. Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63: 229-232. PMID 17329820 DOI: 10.1107/S1744309107007889  0.281
2018 Zhang F, Kang Y, Wang M, Li Y, Xu T, Yang W, Song H, Wu H, Shu Q, Jin P. Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets. Human Molecular Genetics. PMID 30107516 DOI: 10.1093/Hmg/Ddy292  0.28
2010 Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Molecular Cell. 38: 101-13. PMID 20385093 DOI: 10.1016/J.Molcel.2010.03.009  0.278
2024 Wang M, Wu H, Jiang W, Ren Y, Yuan X, Wang Y, Zhou J, Feng W, Wang Y, Xu T, Zhang D, Fang Y, He C, Li W. Differences in nature killer cell response and interference with mitochondrial DNA induced apoptosis in moxifloxacin environment. International Immunopharmacology. 132: 111970. PMID 38608472 DOI: 10.1016/j.intimp.2024.111970  0.277
2017 Yu J, Wu H, Liu ZY, Zhu Q, Shan C, Zhang KQ. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation. International Journal of Molecular Medicine. PMID 28849106 DOI: 10.3892/ijmm.2017.3098  0.277
2016 Shao M, Li L, Song S, Wu W, Peng P, Yang C, Zhang M, Duan F, Jia D, Zhang J, Wu H, Zhao R, Wang L, Ruan Y, Gu J. E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation. Cellular Signalling. 28: 1530-1536. PMID 27443248 DOI: 10.1016/j.cellsig.2016.07.007  0.277
2020 Meng X, Zhang J, Wu H, Yu D, Fang X. Aspartic Protease Amuc_1434* Inhibits Human Colorectal Cancer LS174T Cell Viability via TRAIL-Mediated Apoptosis Pathway. International Journal of Molecular Sciences. 21. PMID 32403433 DOI: 10.3390/ijms21093385  0.276
2024 Wu H, Lu A, Yuan J, Yu Y, Lv C, Lu J. Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms. Cell Death Discovery. 10: 226. PMID 38734665 DOI: 10.1038/s41420-024-01994-5  0.276
2024 Yan X, Xu K, Xu Z, Shi C, Lai B, Wu H, Yang S, Sheng L, Wang K, Zheng Y, Ouyang G, Yang D. GLYR1 transcriptionally regulates PER3 expression to promote the proliferation and migration of multiple myeloma. Genomics. 110846. PMID 38642856 DOI: 10.1016/j.ygeno.2024.110846  0.276
2007 Feng W, Wu H, Chan LN, Zhang M. The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization. The Embo Journal. 26: 2786-96. PMID 17476308 DOI: 10.1038/Sj.Emboj.7601702  0.276
2023 Fan P, Meng H, Hao W, Zheng Y, Li H, Zhang Z, Du L, Guo X, Wang D, Wang Y, Wu H. Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis. Food & Function. PMID 37157847 DOI: 10.1039/d3fo00967j  0.275
2020 Hou S, Zhang X, Du H, Ning X, Wu H, Li C, Liu Y, Sun Z, Du Z, Jin M. Silica nanoparticles induce mitochondrial pathway-dependent apoptosis by activating unfolded protein response in human neuroblastoma cells. Environmental Toxicology. PMID 33270327 DOI: 10.1002/tox.23071  0.275
2023 Li J, Wang W, Yuan Y, Cui X, Bian H, Wen H, Zhang X, Yu H, Wu H. Pinellia ternata lectin induces inflammation through TLR4 receptor and mediates PI3K/Akt/mTOR axis to regulate NF-κB signaling pathway. Toxicology. 153430. PMID 36669722 DOI: 10.1016/j.tox.2023.153430  0.275
2022 Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H. Structural principles of B-cell antigen receptor assembly. Nature. PMID 36228656 DOI: 10.1038/s41586-022-05412-7  0.274
2023 Du T, Song Y, Ray A, Yao Y, Samur MK, Shen C, Penailillo J, Sewastianik T, Tai YT, Fulciniti M, Munshi NC, Wu H, Carrasco RD, Chauhan D, Anderson KC, et al. Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma. Blood. PMID 36630605 DOI: 10.1182/blood.2022017897  0.274
2021 Hu S, Li Y, Nie C, Zhang J, Bai X, Wu H, Shen T, Hu W, Wang J. Structure and pro-inflammatory activities of bran polysaccharides from a novel wheat kernel. Journal of Food Biochemistry. e14008. PMID 34811774 DOI: 10.1111/jfbc.14008  0.274
2018 Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, Sehgal SA, Wang X, Wang J, Shang Y, Jiang Z, Liu L, Chen Q. STING directly activates autophagy to tune the innate immune response. Cell Death and Differentiation. PMID 30568238 DOI: 10.1038/s41418-018-0251-z  0.274
2006 Guasparri I, Wu H, Cesarman E. The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling. Embo Reports. 7: 114-9. PMID 16311516 DOI: 10.1038/Sj.Embor.7400580  0.274
2012 Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X. A class of allosteric caspase inhibitors identified by high-throughput screening. Molecular Cell. 47: 585-95. PMID 22795132 DOI: 10.1016/J.Molcel.2012.06.007  0.273
2010 Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 465: 885-90. PMID 20485341 DOI: 10.1038/nature09121  0.272
2020 Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, ... Wu H, et al. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell. PMID 32533918 DOI: 10.1016/J.Molcel.2020.05.029  0.272
2024 Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, et al. Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway. Nature Microbiology. PMID 38649411 DOI: 10.1038/s41564-024-01684-z  0.272
2020 He Y, Su W, He X, Chen T, Zeng X, Yan Z, Zhang W, Yang W, Guo J, Wu H. Pharmacokinetics and biotransformation investigation in beagle dog of active compounds from naoxintong capsule. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 133: 110940. PMID 33227707 DOI: 10.1016/j.biopha.2020.110940  0.272
2021 Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, ... ... Wu H, et al. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. The Journal of Experimental Medicine. 218. PMID 34554188 DOI: 10.1084/jem.20201656  0.272
2008 Feng W, Wu H, Chan LN, Zhang M. Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment. The Journal of Biological Chemistry. 283: 23440-9. PMID 18550519 DOI: 10.1074/Jbc.M802482200  0.272
2023 Cai J, Wu H, Wang C, Chen Y, Zhang D, Guan S, Fu B, Jin Y, Qian C. Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. Bmc Immunology. 24: 51. PMID 38066482 DOI: 10.1186/s12865-023-00578-9  0.271
2023 Du G, Zhao L, Zheng Y, Belfetmi A, Cai T, Xu B, Heyninck K, Van Den Heede K, Buyse MA, Fontana P, Bowman M, Lin LL, Wu H, Chou JJ. Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Research. PMID 36604598 DOI: 10.1038/s41422-022-00755-2  0.271
2024 Chen X, Wu H, Li P, Peng W, Wang Y, Zhang X, Zhang A, Li J, Meng F, Wang W, Su W. Unraveling the Mechanism of Xiaochaihu Granules in Alleviating Yeast-Induced Fever Based on Network Analysis and Experimental Validation. Pharmaceuticals (Basel, Switzerland). 17. PMID 38675434 DOI: 10.3390/ph17040475  0.271
2017 Choi JY, Qiao Q, Hong SH, Kim CM, Jeong JH, Kim YG, Jung YK, Wu H, Park HH. CIDE domains form functionally important higher-order assemblies for DNA fragmentation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652364 DOI: 10.1073/pnas.1705949114  0.271
2015 Wu H, Liu Q, Cai T, Chen YD, Wang ZF. Induction of microRNA-146a is involved in curcumin-mediated enhancement of temozolomide cytotoxicity against human glioblastoma. Molecular Medicine Reports. PMID 26239619 DOI: 10.3892/mmr.2015.4087  0.271
2021 Huang B, Jiang Z, Wu S, Wu H, Zhang X, Chen J, Zhao F, Liu J. RCAN1.4 suppresses the osteosarcoma growth and metastasis via interfering with the calcineurin/NFAT signaling pathway. Journal of Bone Oncology. 30: 100383. PMID 34336566 DOI: 10.1016/j.jbo.2021.100383  0.27
2014 Yang C, David L, Qiao Q, Damko E, Wu H. The CBM signalosome: potential therapeutic target for aggressive lymphoma? Cytokine & Growth Factor Reviews. 25: 175-83. PMID 24411492 DOI: 10.1016/J.Cytogfr.2013.12.008  0.27
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2015 Wu H, Lu MH, Wang W, Zhang MY, Zhu QQ, Xia YY, Xu RX, Yang Y, Chen LH, Ma QH. Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy. Journal of Alzheimer's Disease : Jad. PMID 25854934 DOI: 10.3233/JAD-143162  0.24
2017 Yu H, Liu L, Wang K, Wu H, Wang W, Zhang X, Cui G, Cui X, Huang J. Upregulation of aquaporin 3 expression by diterpenoids in Euphorbia pekinensis is associated with activation of the NF-κB signaling pathway in the co-culture system of HT-29 and RAW 264.7 cells. Biochimie. PMID 29129744 DOI: 10.1016/j.biochi.2017.11.006  0.24
2023 Liu R, Li T, Xu H, Yu G, Zhang T, Wang J, Sun Y, Bi Y, Feng X, Wu H, Zhang C, Sun Y. Systems biology strategy through integrating metabolomics and network pharmacology to reveal the mechanisms of Xiaopi Hewei Capsule improves functional dyspepsia. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1226: 123676. PMID 37329776 DOI: 10.1016/j.jchromb.2023.123676  0.24
2018 Wu H, Xu X, Li J, Gong J, Li M. TIM‑4 blockade of KCs combined with exogenous TGF‑β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts. International Journal of Molecular Medicine. PMID 29620252 DOI: 10.3892/ijmm.2018.3606  0.24
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2017 Maier A, Wu H, Cordasic N, Oefner P, Dietel B, Thiele C, Weidemann A, Eckardt KU, Warnecke C. Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28760743 DOI: 10.1096/Fj.201700235R  0.239
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2021 Wu H, Zheng S, Zhang J, Xu S, Miao Z. Cadmium induces endoplasmic reticulum stress-mediated apoptosis in pig pancreas via the increase of Th1 cells. Toxicology. 152790. PMID 33891997 DOI: 10.1016/j.tox.2021.152790  0.239
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2017 Liu J, Yao X, Wu D, Ye Y, Wu Q, Liu S, Wu H. Effect of TW37 on the growth of H1975 EGFR‑TKI‑resistant lung cancer cells and its underlying mechanisms. Molecular Medicine Reports. PMID 29207200 DOI: 10.3892/mmr.2017.8181  0.238
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2019 Mao Y, Huang Y, Zhang Y, Wang C, Wu H, Tian X, Liu Y, Hou B, Liang Y, Rong H, Gu X, Ma Z. Cannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord. Molecular Medicine Reports. PMID 31661120 DOI: 10.3892/mmr.2019.10772  0.238
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2015 Wu H, Xu LL, Teuscher P, Liu H, Kaplan MH, Dent AL. An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 26188063 DOI: 10.4049/Jimmunol.1500335  0.238
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2017 Sun W, Liu X, Zhang H, Song Y, Li T, Liu X, Liu Y, Guo L, Wang F, Yang T, Guo W, Wu J, Jin H, Wu H. Epigallocatechin Gallate Upregulates NRF2 to Prevent Diabetic Nephropathy via Disabling KEAP1. Free Radical Biology & Medicine. PMID 28457936 DOI: 10.1016/j.freeradbiomed.2017.04.365  0.237
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2019 Wu H, Zhu H, Zhuang Y, Zhang J, Ding X, Zhan L, Luo S, Zhang Q, Sun F, Zhang M, Pan Z, Lu Y. LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway. Journal of Cellular and Molecular Medicine. PMID 31749326 DOI: 10.1111/jcmm.14781  0.236
2024 Shi YZ, Wu H, Li SS, Li HZ, Zhang BG, Tan YL. ABC2A: A Straightforward and Fast Method for the Accurate Backmapping of RNA Coarse-Grained Models to All-Atom Structures. Molecules (Basel, Switzerland). 29. PMID 38542881 DOI: 10.3390/molecules29061244  0.236
2018 Yao B, Li Y, Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, Cheng Y, Huang L, Phillips BL, Xu T, ... ... Wu H, et al. Active N-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons. Molecular Cell. PMID 30078725 DOI: 10.1016/J.Molcel.2018.07.005  0.236
2021 Wu H, Xu H, Jia D, Li T, Xia L. METTL3-induced UCK2 mA hypermethylation promotes melanoma cancer cell metastasis via the WNT/β-catenin pathway. Annals of Translational Medicine. 9: 1155. PMID 34430596 DOI: 10.21037/atm-21-2906  0.236
2023 He R, Chen H, Wu H, Liu J, Chen W, Zhang M, Chen W, Zhong Q. Proteomics reveals energy limitation and amino acid consumption as antibacterial mechanism of linalool against and its application in fresh beef preservation. Food Chemistry: X. 19: 100837. PMID 37780265 DOI: 10.1016/j.fochx.2023.100837  0.235
2019 Wu H, Ting JM, Weiss TM, Tirrell MV. Interparticle Interactions in Dilute Solutions of Polyelectrolyte Complex Micelles. Acs Macro Letters. 8: 819-825. PMID 35619501 DOI: 10.1021/acsmacrolett.9b00226  0.235
2011 Liu XQ, Wu H, Yu HL, Zhao TF, Pan YZ, Shi RJ. Purification of a lectin from Arisaema erubescens (Wall.) Schott and its pro-inflammatory effects. Molecules (Basel, Switzerland). 16: 9480-94. PMID 22083235 DOI: 10.3390/molecules16119480  0.235
2020 Hatcher JM, Yang G, Wang L, Ficarro SB, Buhrlage S, Wu H, Marto JA, Treon SP, Gray NS. Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. Acs Medicinal Chemistry Letters. 11: 2238-2243. PMID 33214835 DOI: 10.1021/acsmedchemlett.0c00378  0.235
2024 Jiang C, Zhang J, Song Y, Song X, Wu H, Jiao R, Li L, Zhang G, Wei D. FOXO1 regulates bovine skeletal muscle cells differentiation by targeting MYH3. International Journal of Biological Macromolecules. 260: 129643. PMID 38253149 DOI: 10.1016/j.ijbiomac.2024.129643  0.235
2014 Wan L, Lu X, Yuan S, Wei Y, Guo F, Shen M, Yuan M, Chakrabarti R, Hua Y, Smith HA, Blanco MA, Chekmareva M, Wu H, Bronson RT, Haffty BG, et al. MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. Cancer Cell. 26: 92-105. PMID 24981741 DOI: 10.1016/J.Ccr.2014.04.027  0.235
2023 Zhu Q, Zhou Y, Wang H, Cao T, Wang X, Liu R, Wu H, Lin B. Fucoxanthin triggers ferroptosis in glioblastoma cells by stabilizing the transferrin receptor. Medical Oncology (Northwood, London, England). 40: 230. PMID 37421513 DOI: 10.1007/s12032-023-02095-6  0.235
2021 Vora SM, Lieberman J, Wu H. Inflammasome activation at the crux of severe COVID-19. Nature Reviews. Immunology. PMID 34373622 DOI: 10.1038/s41577-021-00588-x  0.235
2016 Wang XZ, Cheng Y, Wang KL, Liu R, Yang XL, Wen HM, Chai C, Liang JY, Wu H. Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells via inhibition of DNA methyltransferase. Cancer Science. PMID 27501331 DOI: 10.1111/cas.13029  0.235
2024 Ye Y, Xie W, Ma Z, Wang X, Wen Y, Li X, Qi H, Wu H, An J, Jiang Y, Lu X, Chen G, Hu S, Blaber EA, Chen X, et al. Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat. Cell Death Discovery. 10: 68. PMID 38336777 DOI: 10.1038/s41420-024-01846-2  0.235
2023 Yang N, Guo J, Wu H, Gao M, Xu S. Eucalyptol ameliorates chlorpyrifos-induced necroptosis in grass carp liver cells by down-regulating ROS/NF-κB pathway. Pesticide Biochemistry and Physiology. 198: 105726. PMID 38225081 DOI: 10.1016/j.pestbp.2023.105726  0.235
2013 Xu GL, Du YF, Cheng J, Huan L, Chen SC, Wei SH, Gong ZN, Cai J, Qiu T, Wu H, Sun T, Ao GZ. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-κB pathway. Toxicology and Applied Pharmacology. 272: 221-9. PMID 23732080 DOI: 10.1016/j.taap.2013.05.025  0.235
2015 Yu HL, Mao SH, Zhao TF, Wu H, Pan YZ, Shu CY. [Antagonistic effect of gingerols against TNF-α release, ROS overproduction and RIP3 expression increase induced by lectin from Pinellia ternata]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 40: 3630-5. PMID 26983212  0.235
2021 Jiao B, Wang M, Feng H, Bao H, Zhang F, Wu H, Wang J, Tang B, Jin P, Shen L. Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats. Human Molecular Genetics. PMID 33749734 DOI: 10.1093/hmg/ddab079  0.234
2022 Yu Z, Wu H, Wang Y. Phoenixin-14 Promotes the Recovery of Neurological Dysfunction After Spinal Cord Injury by Regulating Microglial Polarization PTEN/Akt Signaling Pathway. Human & Experimental Toxicology. 41: 9603271221111345. PMID 35968813 DOI: 10.1177/09603271221111345  0.234
2022 Bo C, Cai R, Fang X, Wu H, Ma Z, Yuan H, Cheng B, Fan J, Ma Q. Transcription factor ZmWRKY20 interacts with ZmWRKY115 to repress expression of ZmbZIP111 for salt tolerance in maize. The Plant Journal : For Cell and Molecular Biology. PMID 35861696 DOI: 10.1111/tpj.15914  0.234
2021 Song HH, Song TC, Yang T, Sun CS, He BQ, Li H, Wang YJ, Li Y, Wu H, Hu YM, Wang YJ. High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury. Neural Regeneration Research. 16: 1848-1855. PMID 33510092 DOI: 10.4103/1673-5374.303039  0.234
2021 Yang ZJ, Wang Q, Wu H, Hu J, Fu H, Qu Y, Yang Y, Cai Q, Efimov A, Wu M, Yen T, Wang Y. Nestin is required for spindle assembly and cell cycle progression in glioblastoma cells. Molecular Cancer Research : McR. PMID 34158391 DOI: 10.1158/1541-7786.MCR-20-0994  0.234
2021 Yang ZJ, Wang Q, Wu H, Hu J, Fu H, Qu Y, Yang Y, Cai Q, Efimov A, Wu M, Yen T, Wang Y. Nestin is required for spindle assembly and cell cycle progression in glioblastoma cells. Molecular Cancer Research : McR. PMID 34158391 DOI: 10.1158/1541-7786.MCR-20-0994  0.234
2014 Wang Y, Zhang Z, Guo W, Sun W, Miao X, Wu H, Cong X, Wintergerst KA, Kong X, Cai L. Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function. American Journal of Physiology. Endocrinology and Metabolism. 307: E14-23. PMID 24801392 DOI: 10.1152/ajpendo.00702.2013  0.234
2018 Yang W, Wu H, Wang Z, Sun Q, Qiao L, Huang B. The APSES Gene Regulates Sporulation in . Frontiers in Microbiology. 9: 1208. PMID 29922271 DOI: 10.3389/fmicb.2018.01208  0.234
2003 Wu H, Wang ZX. The mechanism of p21-activated kinase 2 autoactivation. The Journal of Biological Chemistry. 278: 41768-78. PMID 12907671 DOI: 10.1074/jbc.M308196200  0.234
2024 Zhao H, Wu H, Guseman A, Abeykoon D, Camara CM, Dalal Y, Fushman D, Papoian GA. The role of cryptic ancestral symmetry in histone folding mechanisms across Eukarya and Archaea. Plos Computational Biology. 20: e1011721. PMID 38181064 DOI: 10.1371/journal.pcbi.1011721  0.234
2023 Sen Santara S, Lee DJ, Crespo Â, Hu JJ, Walker C, Ma X, Zhang Y, Chowdhury S, Meza-Sosa KF, Lewandrowski M, Zhang H, Rowe M, McClelland A, Wu H, Junqueira C, et al. The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Nature. PMID 37020026 DOI: 10.1038/s41586-023-05912-0  0.234
2021 Wu H, Tong Y, Zhou R, Wang Y, Wang Z, Ding T, Huang B. Mr-AbaA Regulates Conidiation by Interacting with the Promoter Regions of Both and in Metarhizium robertsii. Microbiology Spectrum. e0082321. PMID 34494863 DOI: 10.1128/Spectrum.00823-21  0.234
2022 Xie WJ, Xia S, Warshel A, Wu H. Electrostatic influence on IL-1 transport through the GSDMD pore. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35115408 DOI: 10.1073/pnas.2120287119  0.234
2020 Wu H, Wang Y, Zhang Y, Xu F, Chen J, Duan L, Zhang T, Wang J, Zhang F. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biology. 32: 101500. PMID 32193146 DOI: 10.1016/j.redox.2020.101500  0.234
2016 Wu H, Fuxreiter M. The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. Cell. 165: 1055-1066. PMID 27203110 DOI: 10.1016/j.cell.2016.05.004  0.234
2023 Man YN, Sun Y, Chen PJ, Wu H, He ML. TAF1D Functions as a Novel Biomarker in Osteosarcoma. Journal of Cancer. 14: 2051-2065. PMID 37497412 DOI: 10.7150/jca.85688  0.234
2021 Song J, Wu H, He F, Qu J, Wang Y, Li C, Liu JH. Citrus sinensis CBF1 Functions in Cold Tolerance by Modulating Putrescine Biosynthesis Through Regulation of ARGININE DECARBOXYLASE. Plant & Cell Physiology. PMID 34478552 DOI: 10.1093/pcp/pcab135  0.234
2022 Huang P, Zhao J, Fowdur M, Liu Y, Wu H, He M. Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway. Translational Cancer Research. 8: 848-855. PMID 35116824 DOI: 10.21037/tcr.2019.05.05  0.234
2022 Ying L, Wu H, Zhou S, Lu H, Ding M, Wang B, Wang S, Mao Y, Xiao F, Li Y. Toll-Like Receptors Signaling Pathway of Quercetin Regulating Avian Beta-Defensin in the Ileum of Broilers. Frontiers in Cell and Developmental Biology. 10: 816771. PMID 35281079 DOI: 10.3389/fcell.2022.816771  0.234
2019 Li G, Tian X, Lv D, Zhang L, Zhang Z, Wang J, Yang M, Tao J, Ma T, Wu H, Ji P, Wu Y, Lian Z, Cui W, Liu G. NLRP7 is expressed in ovine ovary and associated with in vitro preimplantation embryo development. Reproduction (Cambridge, England). PMID 31505467 DOI: 10.1530/REP-19-0081  0.234
2012 Nie YC, Wu H, Li PB, Xie LM, Luo YL, Shen JG, Su WW. Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. European Journal of Pharmacology. 690: 207-13. PMID 22766066 DOI: 10.1016/j.ejphar.2012.06.040  0.233
2017 Li X, Chen H, Xue L, Pang X, Zhang X, Zhu Z, Zhu W, Wang Z, Wu H. p53 performs an essential role in mediating the oncogenic stimulus triggered by loss of expression of neurofibromatosis type 2 during in vitro tumor progression. Oncology Letters. 14: 2223-2231. PMID 28789444 DOI: 10.3892/ol.2017.6445  0.233
2022 Zhang J, Li S, Zhang J, Zhang W, Jiang J, Wu H, Wu E, Feng Y, Yang L, Li Z. Docetaxel resistance-derived LINC01085 contributes to the immunotherapy of hormone-independent prostate cancer by activating the STING/MAVS signaling pathway. Cancer Letters. 545: 215829. PMID 35868534 DOI: 10.1016/j.canlet.2022.215829  0.233
2021 Hu C, Liu H, Pang B, Wu H, Lin X, Zhen Y, Yi H. Supraphysiological estradiol promotes human T follicular helper cell differentiation and favours humoural immunity during in vitro fertilization. Journal of Cellular and Molecular Medicine. PMID 34032001 DOI: 10.1111/jcmm.16651  0.233
2022 Wang J, Yu C, Zhuang J, Qi W, Jiang J, Liu X, Zhao W, Cao Y, Wu H, Qi J, Zhao RC. The role of phosphatidylserine on the membrane in immunity and blood coagulation. Biomarker Research. 10: 4. PMID 35033201 DOI: 10.1186/s40364-021-00346-0  0.233
2022 Wang G, Guo Z, Zhang X, Wu H, Bai X, Zhang H, Hu R, Han S, Pang Y, Gao Z, Yan L, Huang C, Zhang L, Pan C, Liu X. Heterologous expression of pediocin/papA in Bacillus subtilis. Microbial Cell Factories. 21: 104. PMID 35643507 DOI: 10.1186/s12934-022-01829-x  0.233
2017 Wu H, Wang J, Ma H, Xiao Z, Dong X. MicroRNA-21 inhibits mitochondria-mediated apoptosis in keloid. Oncotarget. 8: 92914-92925. PMID 29190966 DOI: 10.18632/oncotarget.21656  0.233
2020 Tong Y, Wu H, Liu Z, Wang Z, Huang B. G-Protein Subunit Gα in Mitochondria, MrGPA1, Affects Conidiation, Stress Resistance, and Virulence of Entomopathogenic Fungus . Frontiers in Microbiology. 11: 1251. PMID 32612588 DOI: 10.3389/fmicb.2020.01251  0.233
2013 He J, Shen L, Wan M, Taranova O, Wu H, Zhang Y. Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nature Cell Biology. 15: 373-84. PMID 23502314 DOI: 10.1038/Ncb2702  0.233
2017 Wang J, Gu J, Wu H, Zhu G, Feng D, Li Y, Guo W, Tian K, Gao G, Gao L. Pentazocine Protects SN4741 Cells Against MPP(+)-Induced Cell Damage via Up-Regulation of the Canonical Wnt/β-Catenin Signaling Pathway. Frontiers in Aging Neuroscience. 9: 196. PMID 28659791 DOI: 10.3389/fnagi.2017.00196  0.233
2019 Wu H, Yang K, Zhang Z, Leisten E, Li Z, Xie H, Liu J, Smith KA, Novakova Z, Barinka C, Tang W. Development of Multi-Functional Histone Deacetylase 6 Degraders with Potent Anti-Myeloma Activity. Journal of Medicinal Chemistry. PMID 31271281 DOI: 10.1021/Acs.Jmedchem.9B00516  0.233
2024 David L, Borges JP, Hollingsworth LR, Volchuk A, Jansen I, Garlick E, Steinberg BE, Wu H. NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks. Cell. PMID 38614101 DOI: 10.1016/j.cell.2024.03.008  0.233
2019 Wang J, Liu J, Sun G, Meng H, Wang J, Guan Y, Yin Y, Zhao Z, Dong X, Yin S, Li H, Cheng Y, Wu H, Wu A, Yu X, et al. Glioblastoma extracellular vesicles induce the tumour-promoting transformation of neural stem cells. Cancer Letters. PMID 31521694 DOI: 10.1016/J.Canlet.2019.09.004  0.232
2020 Yang K, Wu H, Zhang Z, Leisten ED, Nie X, Liu B, Wen Z, Zhang J, Cunningham MD, Tang W. Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. Acs Medicinal Chemistry Letters. 11: 575-581. PMID 32292566 DOI: 10.1021/Acsmedchemlett.0C00046  0.232
2022 Meza-Sosa KF, Miao R, Navarro F, Zhang Z, Zhang Y, Hu JJ, Hartford CCR, Li XL, Pedraza-Alva G, Pérez-Martínez L, Lal A, Wu H, Lieberman J. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Molecular Cell. PMID 35104452 DOI: 10.1016/j.molcel.2022.01.001  0.232
2020 Hu J, Yang Z, Wu H, Wang D. Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis. International Immunopharmacology. 85: 106620. PMID 32504995 DOI: 10.1016/j.intimp.2020.106620  0.232
2016 Wu H, Zhou J, Zeng C, Wu D, Mu Z, Chen B, Xie Y, Ye Y, Liu J. Curcumin increases exosomal TCF21 thus suppressing exosome-induced lung cancer. Oncotarget. PMID 27894084 DOI: 10.18632/oncotarget.13499  0.232
2020 Zuo Y, Yin L, Cheng X, Li J, Wu H, Liu X, Gu E, Wu J. Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice. Frontiers in Cellular Neuroscience. 14: 251. PMID 32903868 DOI: 10.3389/fncel.2020.00251  0.232
2022 Miao S, Zhou J, Liu B, Lei X, Wang T, Hao X, Cheng P, Wu H, Song Y, Pei G, Bi L. A 3D bioprinted nano-laponite hydrogel construct promotes osteogenesis by activating PI3K/AKT signaling pathway. Materials Today. Bio. 16: 100342. PMID 35847377 DOI: 10.1016/j.mtbio.2022.100342  0.232
2022 Ma W, Wu H, Li G, Yan L, Wang L, Zhao M, Guan S, Xu S, Guo X, Liu F, Ji P, Wusiman A, Liu G. Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora. Frontiers in Endocrinology. 13: 966120. PMID 36060949 DOI: 10.3389/fendo.2022.966120  0.232
2018 Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Ji W, Xu T, Liu L, Chen Q. A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. The Embo Journal. PMID 30591555 DOI: 10.15252/embj.201798786  0.232
2022 Miao Z, Miao Z, Shi X, Wu H, Yao Y, Xu S. The antagonistic effect of selenium on lead-induced apoptosis and necroptosis via P38/JNK/ERK pathway in chicken kidney. Ecotoxicology and Environmental Safety. 231: 113176. PMID 35026588 DOI: 10.1016/j.ecoenv.2022.113176  0.232
2016 Jin YP, Wu H, Yu HL, Pan YZ, Chen YQ, Wang KL, Zhang CC, Wang W. [Antagonism mechanism of gingerols against inflammatory effect of toxic raphides from Pinella pedatisecta]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 41: 1087-1092. PMID 28875675  0.232
2023 Wang K, Tang J, Fan S, Su H, Yu R, Zhang Y, Wu H, Lv Y, Zhang S, Zou X. ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways. Neoplasia (New York, N.Y.). 45: 100936. PMID 37769529 DOI: 10.1016/j.neo.2023.100936  0.232
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