| Year |
Citation |
Score |
| 2024 |
Wang C, Liu Y, Lanier M, Yeager A, Singh I, Gumpper RH, Krumm BE, DeLeon C, Zhang S, Boehm M, Pittner R, Baron A, Dvorak L, Bacon C, Shoichet BK, ... ... Roth BL, et al. High-affinity agonists reveal recognition motifs for the MRGPRD GPCR. Cell Reports. 43: 114942. PMID 39580805 DOI: 10.1016/j.celrep.2024.114942 |
0.325 |
|
| 2024 |
Kim Y, Gumpper RH, Liu Y, Kocak DD, Xiong Y, Cao C, Deng Z, Krumm BE, Jain MK, Zhang S, Jin J, Roth BL. Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature. PMID 38600377 DOI: 10.1038/s41586-024-07253-y |
0.564 |
|
| 2023 |
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, ... ... Roth BL, et al. AlphaFold2 structures template ligand discovery. Biorxiv : the Preprint Server For Biology. PMID 38187536 DOI: 10.1101/2023.12.20.572662 |
0.524 |
|
| 2023 |
Schmitz G, Roth BL. G protein coupled receptors as targets for transformative neuropsychiatric therapeutics. American Journal of Physiology. Cell Physiology. PMID 37067459 DOI: 10.1152/ajpcell.00397.2022 |
0.344 |
|
| 2023 |
Cao C, Roth BL. The structure, function, and pharmacology of MRGPRs. Trends in Pharmacological Sciences. 44: 237-251. PMID 36870785 DOI: 10.1016/j.tips.2023.02.002 |
0.301 |
|
| 2023 |
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE. Structures of the entire human opioid receptor family. Cell. PMID 36638794 DOI: 10.1016/j.cell.2022.12.026 |
0.492 |
|
| 2023 |
Gumpper RH, Roth BL. SnapShot: Psychedelics and serotonin receptor signaling. Cell. 186: 232-232.e1. PMID 36608655 DOI: 10.1016/j.cell.2022.12.020 |
0.325 |
|
| 2022 |
Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, ... ... Roth BL, et al. Bespoke library docking for 5-HT receptor agonists with antidepressant activity. Nature. PMID 36171289 DOI: 10.1038/s41586-022-05258-z |
0.371 |
|
| 2022 |
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, ... ... Roth BL, et al. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. PMID 36087581 DOI: 10.1016/j.neuron.2022.08.006 |
0.383 |
|
| 2022 |
Schmitz GP, Jain MK, Slocum ST, Roth BL. 5-HT SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics. Acs Chemical Neuroscience. 13: 2386-2398. PMID 35894503 DOI: 10.1021/acschemneuro.1c00815 |
0.552 |
|
| 2022 |
Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL. Inactive and active state structures template selective tools for the human 5-HT receptor. Nature Structural & Molecular Biology. 29: 677-687. PMID 35835867 DOI: 10.1038/s41594-022-00796-6 |
0.385 |
|
| 2022 |
McClure-Begley TD, Roth BL. The promises and perils of psychedelic pharmacology for psychiatry. Nature Reviews. Drug Discovery. PMID 35301459 DOI: 10.1038/s41573-022-00421-7 |
0.314 |
|
| 2022 |
Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, Amabo V, O'Donnell H, Lak P, Basbaum AI, Roth BL, Shoichet BK. Structure-Based Design of a Chemical Probe Set for the 5-HT Serotonin Receptor. Journal of Medicinal Chemistry. PMID 35195401 DOI: 10.1021/acs.jmedchem.1c02031 |
0.35 |
|
| 2022 |
Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov K, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, et al. Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX. British Journal of Pharmacology. PMID 35106752 DOI: 10.1111/bph.15811 |
0.642 |
|
| 2021 |
Sadybekov AA, Sadybekov AV, Liu Y, Iliopoulos-Tsoutsouvas C, Huang XP, Pickett J, Houser B, Patel N, Tran NK, Tong F, Zvonok N, Jain MK, Savych O, Radchenko DS, Nikas SP, ... ... Roth BL, et al. Synthon-based ligand discovery in virtual libraries of over 11 billion compounds. Nature. PMID 34912117 DOI: 10.1038/s41586-021-04220-9 |
0.465 |
|
| 2021 |
Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, et al. Structures of the human dopamine D3 receptor-G complexes. Molecular Cell. PMID 33548201 DOI: 10.1016/j.molcel.2021.01.003 |
0.318 |
|
| 2021 |
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, ... ... Roth BL, et al. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews. 73: 310-520. PMID 33370241 DOI: 10.1124/pr.118.015552 |
0.379 |
|
| 2020 |
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor. Cell. 182: 1574-1588.e19. PMID 32946782 DOI: 10.1016/J.Cell.2020.08.024 |
0.438 |
|
| 2020 |
Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, ... ... Roth BL, et al. The activities of drug inactive ingredients on biological targets. Science (New York, N.Y.). 369: 403-413. PMID 32703874 DOI: 10.1126/Science.Aaz9906 |
0.344 |
|
| 2020 |
Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, Takahashi M, Huang XP, Slocum ST, DiBerto JF, Xiong Y, Urushihata T, Hirabayashi T, Fujimoto A, Mimura K, ... ... Roth BL, et al. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature Neuroscience. PMID 32632286 DOI: 10.1038/S41593-020-0661-3 |
0.37 |
|
| 2020 |
Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT. TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. Nature Chemical Biology. PMID 32367019 DOI: 10.1038/S41589-020-0535-8 |
0.355 |
|
| 2020 |
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, ... ... Roth BL, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. PMID 32353859 DOI: 10.1038/S41586-020-2286-9 |
0.334 |
|
| 2020 |
Krumm B, Roth BL. A Structural Understanding of Class B GPCR Selectivity and Activation Revealed. Structure (London, England : 1993). 28: 277-279. PMID 32130889 DOI: 10.1016/j.str.2020.02.004 |
0.329 |
|
| 2020 |
Krumm B, Roth BL. A self-activating orphan receptor. Nature. 579: 35-36. PMID 32123359 DOI: 10.1038/d41586-020-00411-y |
0.401 |
|
| 2020 |
Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, Roth BL. Nanobody-enabled monitoring of kappa opioid receptor states. Nature Communications. 11: 1145. PMID 32123179 DOI: 10.1038/S41467-020-14889-7 |
0.34 |
|
| 2020 |
Patel N, Huang XP, Grandner J, Johansson LC, Stauch B, McCorvy JD, Liu Y, Roth B, Katritch V. Structure-based discovery of potent and selective melatonin receptor agonists. Elife. 9. PMID 32118583 DOI: 10.7554/Elife.53779 |
0.433 |
|
| 2020 |
Stein RM, Kang HJ, McCorvy JD, Glatfelter GC, Jones AJ, Che T, Slocum S, Huang XP, Savych O, Moroz YS, Stauch B, Johansson LC, Cherezov V, Kenakin T, Irwin JJ, ... ... Roth BL, et al. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature. PMID 32040955 DOI: 10.1038/s41586-020-2027-0 |
0.301 |
|
| 2020 |
Patel N, Huang XP, Grandner JM, Johansson LC, Stauch B, McCorvy JD, Liu Y, Roth B, Katritch V. Author response: Structure-based discovery of potent and selective melatonin receptor agonists Elife. DOI: 10.7554/Elife.53779.Sa2 |
0.415 |
|
| 2020 |
Glatfelter G, Stein R, Kang HJ, Jones A, Irwin J, Roth B, Shoichet B, Dubocovich M. In vivo
Efficacy of Novel Type Preferring MT
1
Melatonin Receptor Inverse Agonists in C3H/HeN Mouse Models of Chronobiological Behavior The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04127 |
0.347 |
|
| 2020 |
Faouzi A, Zaidi S, Che T, Kormos C, Zhang T, Madasu M, Eans S, Simons C, Pan Y, McLaughlin J, Carroll I, Hassani RA, Roth B, Katritch V, Majumdar S. Design of first in class bitopic ligands targeting the sodium binding pocket in opioid receptors The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02437 |
0.382 |
|
| 2019 |
Foster SR, Hauser AS, Vedel L, Strachan RT, Huang XP, Gavin AC, Shah SD, Nayak AP, Haugaard-Kedström LM, Penn RB, Roth BL, Bräuner-Osborne H, Gloriam DE. Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. Cell. 179: 895-908.e21. PMID 31675498 DOI: 10.1016/J.Cell.2019.10.010 |
0.383 |
|
| 2019 |
Zarzycka B, Zaidi SA, Roth BL, Katritch V. Harnessing Ion-Binding Sites for GPCR Pharmacology. Pharmacological Reviews. 71: 571-595. PMID 31551350 DOI: 10.1124/Pr.119.017863 |
0.374 |
|
| 2019 |
Rosas R, Huang XP, Roth BL, Dockendorff C. β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists. Acs Medicinal Chemistry Letters. 10: 1353-1356. PMID 31531209 DOI: 10.1021/acsmedchemlett.9b00335 |
0.326 |
|
| 2019 |
Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP. Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT) receptor agonist without 5-HT agonism. European Journal of Medicinal Chemistry. 182: 111626. PMID 31445232 DOI: 10.1016/J.Ejmech.2019.111626 |
0.436 |
|
| 2019 |
Roth BL. Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs. Nature Structural & Molecular Biology. 26: 535-544. PMID 31270468 DOI: 10.1038/s41594-019-0252-8 |
0.406 |
|
| 2019 |
Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, ... ... Roth BL, et al. Structural basis of ligand recognition at the human MT melatonin receptor. Nature. PMID 31019306 DOI: 10.1038/S41586-019-1141-3 |
0.461 |
|
| 2019 |
Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, ... ... Roth BL, et al. XFEL structures of the human MT melatonin receptor reveal the basis of subtype selectivity. Nature. PMID 31019305 DOI: 10.1038/s41586-019-1144-0 |
0.446 |
|
| 2019 |
Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J. Intra-islet glucagon signaling is critical for maintaining glucose homeostasis. Jci Insight. 5. PMID 31012868 DOI: 10.1172/Jci.Insight.127994 |
0.327 |
|
| 2019 |
Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J. D2 Dopamine Receptor G protein-biased Partial Agonists Based on Cariprazine. Journal of Medicinal Chemistry. PMID 30964661 DOI: 10.1021/Acs.Jmedchem.9B00508 |
0.445 |
|
| 2019 |
Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs NM, McCorvy J, Caron MG, Roth BL, Jin J. Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. Journal of Medicinal Chemistry. PMID 30875219 DOI: 10.1021/Acs.Jmedchem.9B00351 |
0.435 |
|
| 2019 |
Roth BL. How structure informs and transforms chemogenetics. Current Opinion in Structural Biology. 57: 9-16. PMID 30818201 DOI: 10.1016/j.sbi.2019.01.016 |
0.38 |
|
| 2019 |
Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. Ultra-large library docking for discovering new chemotypes. Nature. PMID 30728502 DOI: 10.1038/S41586-019-0917-9 |
0.387 |
|
| 2019 |
Andrade R, Barnes NM, Baxter G, Bockaert J, Branchek T, Butler A, Cohen ML, Dumuis A, Eglen RM, Göthert M, Hamblin M, Hamon M, Hartig PR, Hen R, Hensler J, ... ... Roth B, et al. 5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f1/2019.4 |
0.337 |
|
| 2018 |
Thompson KJ, Khajehali E, Bradley SJ, Navarrete JS, Huang XP, Slocum S, Jin J, Liu J, Xiong Y, Olsen RHJ, Diberto JF, Boyt KM, Pina MM, Pati D, Molloy C, ... ... Roth BL, et al. DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs and . Acs Pharmacology & Translational Science. 1: 61-72. PMID 30868140 DOI: 10.1021/acsptsci.8b00012 |
0.323 |
|
| 2018 |
Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in kappa opioid agonist binding revealed through PET imaging. Acs Chemical Neuroscience. PMID 30212182 DOI: 10.1021/Acschemneuro.8B00293 |
0.345 |
|
| 2018 |
Che T, Roth BL. Phosphoproteomics illuminates opioid actions. Biochemistry. PMID 30179451 DOI: 10.1021/acs.biochem.8b00809 |
0.351 |
|
| 2018 |
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL. Structural determinants of 5-HT receptor activation and biased agonism. Nature Structural & Molecular Biology. PMID 30127358 DOI: 10.1038/S41594-018-0116-7 |
0.476 |
|
| 2018 |
Weiss DR, Karpiak J, Huang XP, Sassano MF, Lyu J, Roth BL, Shoichet BK. Selectivity Challenges in Docking Screens for GPCR Targets and Anti-Targets. Journal of Medicinal Chemistry. PMID 29990431 DOI: 10.1021/Acs.Jmedchem.8B00718 |
0.395 |
|
| 2018 |
Krumm B, Roth BL. Activation mechanisms for a universal signalling protein. Nature. 557: 318-319. PMID 29752449 DOI: 10.1038/d41586-018-04977-6 |
0.382 |
|
| 2018 |
Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, et al. High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. Chemical Science. 9: 3192-3199. PMID 29732102 DOI: 10.1039/C7Sc04698G |
0.417 |
|
| 2018 |
Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. Correction: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. Plos One. 13: e0194984. PMID 29566092 DOI: 10.1371/journal.pone.0194984 |
0.609 |
|
| 2018 |
Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL. Structure of the Ddopamine receptor bound to the atypical antipsychotic drug risperidone. Nature. PMID 29466326 DOI: 10.1038/Nature25758 |
0.412 |
|
| 2018 |
Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, ... ... Roth BL, et al. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell. PMID 29398112 DOI: 10.1016/J.Cell.2018.01.001 |
0.493 |
|
| 2018 |
Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, ... ... Roth BL, et al. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell. PMID 29307491 DOI: 10.1016/J.Cell.2017.12.011 |
0.371 |
|
| 2017 |
McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL. Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nature Chemical Biology. PMID 29227473 DOI: 10.1038/Nchembio.2527 |
0.351 |
|
| 2017 |
Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS. The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nature Communications. 8: 1910. PMID 29208933 DOI: 10.1038/S41467-017-02084-0 |
0.36 |
|
| 2017 |
Huang XP, Che T, Mangano TJ, Le Rouzic V, Pan YX, Cameron MD, Baumann MH, Pasternak GW, Roth BL. Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo. Jci Insight. 2. PMID 29202454 DOI: 10.1172/Jci.Insight.97222 |
0.369 |
|
| 2017 |
Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science (New York, N.Y.). 358: 381-386. PMID 29051383 DOI: 10.1126/Science.Aan5468 |
0.431 |
|
| 2017 |
Roth BL, Irwin JJ, Shoichet BK. Discovery of new GPCR ligands to illuminate new biology. Nature Chemical Biology. 13: 1143-1151. PMID 29045379 DOI: 10.1038/Nchembio.2490 |
0.385 |
|
| 2017 |
Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, et al. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29042451 DOI: 10.1096/Fj.201700555R |
0.416 |
|
| 2017 |
Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX, Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. PMID 28807672 DOI: 10.1016/J.Neuropharm.2017.08.016 |
0.333 |
|
| 2017 |
Wacker D, Stevens RC, Roth BL. How Ligands Illuminate GPCR Molecular Pharmacology. Cell. 170: 414-427. PMID 28753422 DOI: 10.1016/J.Cell.2017.07.009 |
0.398 |
|
| 2017 |
Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V. Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716900 DOI: 10.1073/Pnas.1700891114 |
0.39 |
|
| 2017 |
Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry. PMID 28657744 DOI: 10.1021/Acs.Jmedchem.7B00584 |
0.432 |
|
| 2017 |
Zheng Z, Huang XP, Mangano TJ, Zou R, Chen X, Zaidi S, Roth BL, Stevens RC, Katritch V. Structure based discovery of new antagonist and biased agonist chemotypes for the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 28339199 DOI: 10.1021/Acs.Jmedchem.7B00109 |
0.395 |
|
| 2017 |
Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC. 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28294132 DOI: 10.1038/Npp.2017.52 |
0.433 |
|
| 2017 |
Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nature Chemical Biology. PMID 28288109 DOI: 10.1038/Nchembio.2334 |
0.405 |
|
| 2017 |
Le Gonidec S, Chaves-Almagro C, Bai Y, Kang HJ, Smith A, Wanecq E, Huang XP, Prats H, Knibiehler B, Roth BL, Barak LS, Caron MG, Valet P, Audigier Y, Masri B. Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28242772 DOI: 10.1096/fj.201601074R |
0.463 |
|
| 2017 |
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 168: 377-389.e12. PMID 28129538 DOI: 10.1016/J.Cell.2016.12.033 |
0.422 |
|
| 2016 |
Kim Y, Lee HM, Xiong Y, Sciaky N, Hulbert SW, Cao X, Everitt JI, Jin J, Roth BL, Jiang YH. Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. Nature Medicine. PMID 28024084 DOI: 10.1038/Nm.4257 |
0.495 |
|
| 2016 |
Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911814 DOI: 10.1073/Pnas.1614347113 |
0.411 |
|
| 2016 |
McCorvy JD, Olsen RH, Roth BL. Psilocybin for depression and anxiety associated with life-threatening illnesses. Journal of Psychopharmacology (Oxford, England). 30: 1209-1210. PMID 27909171 DOI: 10.1177/0269881116675771 |
0.527 |
|
| 2016 |
Chen X, McCorvy JD, Fischer MG, Butler KV, Shen Y, Roth BL, Jin J. Discovery of G Protein-biased D2 Dopamine Receptor Partial Agonists. Journal of Medicinal Chemistry. PMID 27805392 DOI: 10.1021/acs.jmedchem.6b01208 |
0.43 |
|
| 2016 |
Sato S, Huang XP, Kroeze W, Roth BL. Discovery and characterization of novel GPR39 agonists allosterically modulated by zinc. Molecular Pharmacology. PMID 27754899 DOI: 10.1124/mol.116.106112 |
0.345 |
|
| 2016 |
Cheng J, McCorvy JD, Giguère PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. Journal of Medicinal Chemistry. PMID 27726356 DOI: 10.1021/Acs.Jmedchem.6B01194 |
0.325 |
|
| 2016 |
Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, ... ... Roth BL, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 1-6. PMID 27533032 DOI: 10.1038/Nature19112 |
0.323 |
|
| 2016 |
Etukala JR, Zhu XY, Eyunni SV, Onyameh EK, Ofori E, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. Bioorganic & Medicinal Chemistry. PMID 27364609 DOI: 10.1016/j.bmc.2016.06.011 |
0.45 |
|
| 2016 |
Ofori E, Zhu XY, Etukala JR, Peprah K, Jordan KR, Adkins AA, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. Bioorganic & Medicinal Chemistry. PMID 27312422 DOI: 10.1016/j.bmc.2016.05.053 |
0.492 |
|
| 2016 |
Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, ... ... Roth BL, et al. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247388 DOI: 10.1073/Pnas.1602070113 |
0.617 |
|
| 2016 |
Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JJ, Caldarone BJ, Roth BL, Kokel D, Peterson RT. σ1 receptor ligands control a switch between passive and active threat responses. Nature Chemical Biology. PMID 27239788 DOI: 10.1038/Nchembio.2089 |
0.325 |
|
| 2016 |
Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, ... ... Roth BL, et al. Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nature Chemical Biology. PMID 27239787 DOI: 10.1038/Nchembio.2097 |
0.3 |
|
| 2016 |
Zhu H, Aryal DK, Olsen RH, Urban DJ, Swearingen A, Forbes S, Roth BL, Hochgeschwender U. Cre dependent DREADD (designer receptors exclusively activated by designer drugs) mice. Genesis (New York, N.Y. : 2000). PMID 27194399 DOI: 10.1002/Dvg.22949 |
0.765 |
|
| 2016 |
Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. Plos Pathogens. 12: e1005651. PMID 27187180 DOI: 10.1371/Journal.Ppat.1005651 |
0.403 |
|
| 2016 |
Wacker D, Roth BL. An alerting structure: human orexin receptor 1. Nature Structural & Molecular Biology. 23: 265-6. PMID 27045444 DOI: 10.1038/Nsmb.3198 |
0.449 |
|
| 2016 |
Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, ... ... Roth BL, et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. Plos One. 11: e0150602. PMID 26963248 DOI: 10.1371/Journal.Pone.0150602 |
0.701 |
|
| 2016 |
Roth BL. DREADDs for Neuroscientists. Neuron. 89: 683-94. PMID 26889809 DOI: 10.1016/j.neuron.2016.01.040 |
0.337 |
|
| 2016 |
Bruchas MR, Roth BL. New Technologies for Elucidating Opioid Receptor Function. Trends in Pharmacological Sciences. PMID 26833118 DOI: 10.1016/J.Tips.2016.01.001 |
0.361 |
|
| 2016 |
Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 26807715 DOI: 10.1038/Nchembio.2007 |
0.302 |
|
| 2015 |
Cheng J, Giguère PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. Journal of Medicinal Chemistry. PMID 26704965 DOI: 10.1021/Acs.Jmedchem.5B01153 |
0.405 |
|
| 2015 |
Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, ... ... Roth BL, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. PMID 26550826 DOI: 10.1038/Nature15699 |
0.63 |
|
| 2015 |
English JG, Roth BL. Chemogenetics-A Transformational and Translational Platform. Jama Neurology. 1-6. PMID 26409113 DOI: 10.1001/jamaneurol.2015.1921 |
0.343 |
|
| 2015 |
Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL. Elucidation of the Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26383016 DOI: 10.1038/Npp.2015.293 |
0.781 |
|
| 2015 |
O'Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wüthrich K, Milon A. NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 112: 11852-7. PMID 26372966 DOI: 10.1073/Pnas.1510117112 |
0.338 |
|
| 2015 |
Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. Bioorganic & Medicinal Chemistry Letters. 25: 3956-60. PMID 26231155 DOI: 10.1016/j.bmcl.2015.07.031 |
0.324 |
|
| 2015 |
Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist. Tetrahedron Letters. 56: 3420-3422. PMID 26120215 DOI: 10.1016/J.Tetlet.2015.01.060 |
0.335 |
|
| 2015 |
Roth BL, Kroeze WK. Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily. The Journal of Biological Chemistry. 290: 19471-7. PMID 26100629 DOI: 10.1074/jbc.R115.654764 |
0.361 |
|
| 2015 |
Salaga M, Polepally PR, Zielinska M, Marynowski M, Fabisiak A, Murawska N, Sobczak K, Sacharczuk M, Do Rego JC, Roth BL, Zjawiony JK, Fichna J. Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice. British Journal of Pharmacology. 172: 4331-41. PMID 26040667 DOI: 10.1111/bph.13212 |
0.35 |
|
| 2015 |
Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y. Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26019014 DOI: 10.1038/Npp.2015.149 |
0.409 |
|
| 2015 |
Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, ... ... Roth BL, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 86: 936-46. PMID 25937170 DOI: 10.1016/J.Neuron.2015.03.065 |
0.794 |
|
| 2015 |
Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nature Structural & Molecular Biology. 22: 362-9. PMID 25895059 DOI: 10.1038/Nsmb.3014 |
0.392 |
|
| 2015 |
Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ. Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2614-22. PMID 25881115 DOI: 10.1038/Npp.2015.109 |
0.635 |
|
| 2015 |
Nocjar C, Alex KD, Sonneborn A, Abbas AI, Roth BL, Pehek EA. Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex. Neuroscience. 297: 22-37. PMID 25818050 DOI: 10.1016/J.Neuroscience.2015.03.050 |
0.767 |
|
| 2015 |
Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, ... ... Roth BL, et al. Structural basis for bifunctional peptide recognition at human δ-opioid receptor. Nature Structural & Molecular Biology. 22: 265-8. PMID 25686086 DOI: 10.1038/Nsmb.2965 |
0.349 |
|
| 2015 |
Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. Journal of Medicinal Chemistry. 58: 1992-2002. PMID 25633969 DOI: 10.1021/Jm5019274 |
0.474 |
|
| 2015 |
McCorvy JD, Roth BL. Structure and function of serotonin G protein-coupled receptors. Pharmacology & Therapeutics. 150: 129-42. PMID 25601315 DOI: 10.1016/j.pharmthera.2015.01.009 |
0.471 |
|
| 2015 |
Chen X, Choo H, Huang XP, Yang X, Stone O, Roth BL, Jin J. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. Acs Chemical Neuroscience. 6: 476-84. PMID 25587888 DOI: 10.1021/Cn500325V |
0.469 |
|
| 2015 |
Zhu H, Roth BL. DREADD: a chemogenetic GPCR signaling platform. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25522378 DOI: 10.1093/ijnp/pyu007 |
0.387 |
|
| 2015 |
White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL. The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo. The Journal of Pharmacology and Experimental Therapeutics. 352: 98-109. PMID 25320048 DOI: 10.1124/Jpet.114.216820 |
0.644 |
|
| 2015 |
Urban DJ, Roth BL. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annual Review of Pharmacology and Toxicology. 55: 399-417. PMID 25292433 DOI: 10.1146/Annurev-Pharmtox-010814-124803 |
0.691 |
|
| 2015 |
Matsunaga F, Gao L, Huang XP, Saven JG, Roth BL, Liu R. Molecular interactions between general anesthetics and the 5HT2B receptor. Journal of Biomolecular Structure & Dynamics. 33: 211-8. PMID 24365264 DOI: 10.1080/07391102.2013.869483 |
0.454 |
|
| 2015 |
Grace P, Wang X, Urban D, Baratta M, Galer E, Strand K, Zhang Y, Yin H, Roth B, Maier S, Watkins L. (250) Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling The Journal of Pain. 16: S38. DOI: 10.1016/J.Jpain.2015.01.167 |
0.595 |
|
| 2015 |
Grace P, Wang X, Urban D, Baratta M, Galer E, Strand K, Zhang Y, Yin H, Roth B, Maier S, Watkins L. Selective manipulation of spinal microglia by chemogenetics: Implications for allodynia and inflammatory signaling Brain, Behavior, and Immunity. 49: e7. DOI: 10.1016/J.Bbi.2015.06.045 |
0.64 |
|
| 2014 |
Cero C, Vostrikov VV, Verardi R, Severini C, Gopinath T, Braun PD, Sassano MF, Gurney A, Roth BL, Vulchanova L, Possenti R, Veglia G, Bartolomucci A. The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism. Structure (London, England : 1993). 22: 1744-53. PMID 25456411 DOI: 10.1016/J.Str.2014.10.001 |
0.42 |
|
| 2014 |
Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK. Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor. European Journal of Medicinal Chemistry. 85: 818-29. PMID 25193297 DOI: 10.1055/S-0032-1307601 |
0.679 |
|
| 2014 |
Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Further evaluation of the tropane analogs of haloperidol. Bioorganic & Medicinal Chemistry Letters. 24: 4294-7. PMID 25070422 DOI: 10.1016/J.Bmcl.2014.07.018 |
0.667 |
|
| 2014 |
Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nature Communications. 5: 4355. PMID 25008467 DOI: 10.1038/Ncomms5355 |
0.688 |
|
| 2014 |
Sternson SM, Roth BL. Chemogenetic tools to interrogate brain functions. Annual Review of Neuroscience. 37: 387-407. PMID 25002280 DOI: 10.1146/Annurev-Neuro-071013-014048 |
0.354 |
|
| 2014 |
Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Identification of a new selective dopamine D4 receptor ligand. Bioorganic & Medicinal Chemistry. 22: 3105-14. PMID 24800940 DOI: 10.1016/J.Bmc.2014.04.026 |
0.692 |
|
| 2014 |
Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. Acs Chemical Neuroscience. 5: 576-87. PMID 24793972 DOI: 10.1021/Cn500082P |
0.425 |
|
| 2014 |
Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC. Allosteric sodium in class A GPCR signaling. Trends in Biochemical Sciences. 39: 233-44. PMID 24767681 DOI: 10.1016/J.Tibs.2014.03.002 |
0.401 |
|
| 2014 |
Giguere PM, Kroeze WK, Roth BL. Tuning up the right signal: chemical and genetic approaches to study GPCR functions. Current Opinion in Cell Biology. 27: 51-5. PMID 24680430 DOI: 10.1016/j.ceb.2013.11.006 |
0.395 |
|
| 2014 |
Zhu H, Pleil KE, Urban DJ, Moy SS, Kash TL, Roth BL. Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1880-92. PMID 24525710 DOI: 10.1038/Npp.2014.35 |
0.607 |
|
| 2014 |
Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Research. 1554: 36-48. PMID 24472579 DOI: 10.1016/J.Brainres.2014.01.036 |
0.304 |
|
| 2014 |
Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. Molecular control of δ-opioid receptor signalling. Nature. 506: 191-6. PMID 24413399 DOI: 10.1038/Nature12944 |
0.387 |
|
| 2014 |
Luo M, Wang XS, Roth BL, Golbraikh A, Tropsha A. Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. Journal of Chemical Information and Modeling. 54: 634-47. PMID 24410373 DOI: 10.1021/Ci400460Q |
0.441 |
|
| 2014 |
Fourches D, Sassano MF, Roth BL, Tropsha A. HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data. Bioinformatics (Oxford, England). 30: 588-9. PMID 24376084 DOI: 10.1093/Bioinformatics/Btt718 |
0.326 |
|
| 2014 |
Liu R, Huang XP, Yeliseev A, Xi J, Roth BL. Novel molecular targets of dezocine and their clinical implications. Anesthesiology. 120: 714-23. PMID 24263237 DOI: 10.1097/ALN.0000000000000076 |
0.461 |
|
| 2014 |
Lee HM, Giguere PM, Roth BL. DREADDs: novel tools for drug discovery and development. Drug Discovery Today. 19: 469-73. PMID 24184433 DOI: 10.1016/j.drudis.2013.10.018 |
0.595 |
|
| 2013 |
Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, et al. Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Acs Medicinal Chemistry Letters. 4: 1005-1010. PMID 24454993 DOI: 10.1021/Ml400312J |
0.397 |
|
| 2013 |
Meltzer HY, Roth BL. Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs. The Journal of Clinical Investigation. 123: 4986-91. PMID 24292660 DOI: 10.1172/Jci70678 |
0.489 |
|
| 2013 |
Carroll FI, Gichinga MG, Williams JD, Vardy E, Roth BL, Mascarella SW, Thomas JB, Navarro HA. 4β-Methyl-5-(3-hydroxyphenyl)morphan opioid agonist and partial agonist derived from a 4β-methyl-5-(3-hydroxyphenyl)morphan pure antagonist. Journal of Medicinal Chemistry. 56: 8826-33. PMID 24144404 DOI: 10.1021/jm401250s |
0.425 |
|
| 2013 |
Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83. PMID 24121503 DOI: 10.1074/Jbc.M113.515668 |
0.425 |
|
| 2013 |
Agulhon C, Boyt KM, Xie AX, Friocourt F, Roth BL, McCarthy KD. Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo. The Journal of Physiology. 591: 5599-609. PMID 24042499 DOI: 10.1113/Jphysiol.2013.261289 |
0.4 |
|
| 2013 |
Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists. Chemmedchem. 8: 1855-64. PMID 24039134 DOI: 10.1002/Cmdc.201300240 |
0.384 |
|
| 2013 |
Becnel J, Johnson O, Majeed ZR, Tran V, Yu B, Roth BL, Cooper RL, Kerut EK, Nichols CD. DREADDs in Drosophila: a pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly. Cell Reports. 4: 1049-59. PMID 24012754 DOI: 10.1016/j.celrep.2013.08.003 |
0.354 |
|
| 2013 |
Munro TA, Huang XP, Inglese C, Perrone MG, Van't Veer A, Carroll FI, Béguin C, Carlezon WA, Colabufo NA, Cohen BM, Roth BL. Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters. Plos One. 8: e70701. PMID 23976952 DOI: 10.1371/Journal.Pone.0070701 |
0.383 |
|
| 2013 |
Ferguson SM, Phillips PE, Roth BL, Wess J, Neumaier JF. Direct-pathway striatal neurons regulate the retention of decision-making strategies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11668-76. PMID 23843534 DOI: 10.1523/Jneurosci.4783-12.2013 |
0.301 |
|
| 2013 |
Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 497: 338-43. PMID 23636324 DOI: 10.1038/Nature12167 |
0.42 |
|
| 2013 |
Arunotayanun W, Dalley JW, Huang XP, Setola V, Treble R, Iversen L, Roth BL, Gibbons S. An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorganic & Medicinal Chemistry Letters. 23: 3411-5. PMID 23602445 DOI: 10.1016/J.Bmcl.2013.03.066 |
0.694 |
|
| 2013 |
Polepally PR, White K, Vardy E, Roth BL, Ferreira D, Zjawiony JK. Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands. Bioorganic & Medicinal Chemistry Letters. 23: 2860-2. PMID 23587424 DOI: 10.1016/J.Bmcl.2013.03.111 |
0.432 |
|
| 2013 |
Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H. Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorganic & Medicinal Chemistry. 21: 2568-76. PMID 23541835 DOI: 10.1016/j.bmc.2013.02.038 |
0.471 |
|
| 2013 |
Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. Plos One. 8: e59334. PMID 23527166 DOI: 10.1371/Journal.Pone.0059334 |
0.694 |
|
| 2013 |
Parnaudeau S, O'Neill PK, Bolkan SS, Ward RD, Abbas AI, Roth BL, Balsam PD, Gordon JA, Kellendonk C. Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron. 77: 1151-62. PMID 23522049 DOI: 10.1016/J.Neuron.2013.01.038 |
0.767 |
|
| 2013 |
Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Structural features for functional selectivity at serotonin receptors. Science (New York, N.Y.). 340: 615-9. PMID 23519215 DOI: 10.1126/Science.1232808 |
0.458 |
|
| 2013 |
Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, ... ... Roth BL, et al. Structural basis for molecular recognition at serotonin receptors. Science (New York, N.Y.). 340: 610-4. PMID 23519210 DOI: 10.1126/Science.1232807 |
0.49 |
|
| 2013 |
Weiss DR, Ahn S, Sassano MF, Kleist A, Zhu X, Strachan R, Roth BL, Lefkowitz RJ, Shoichet BK. Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. Acs Chemical Biology. 8: 1018-26. PMID 23485065 DOI: 10.1021/Cb400103F |
0.457 |
|
| 2013 |
McElligott ZA, Fox ME, Walsh PL, Urban DJ, Ferrel MS, Roth BL, Wightman RM. Noradrenergic synaptic function in the bed nucleus of the stria terminalis varies in animal models of anxiety and addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1665-73. PMID 23467277 DOI: 10.1038/Npp.2013.63 |
0.602 |
|
| 2013 |
Sassano MF, Doak AK, Roth BL, Shoichet BK. Colloidal aggregation causes inhibition of G protein-coupled receptors. Journal of Medicinal Chemistry. 56: 2406-14. PMID 23437772 DOI: 10.1021/Jm301749Y |
0.399 |
|
| 2013 |
Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nature Chemical Biology. 9: 257-63. PMID 23396078 DOI: 10.1038/Nchembio.1183 |
0.625 |
|
| 2013 |
Vardy E, Roth BL. Conformational ensembles in GPCR activation. Cell. 152: 385-6. PMID 23374334 DOI: 10.1016/j.cell.2013.01.025 |
0.325 |
|
| 2013 |
Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, ... ... Roth BL, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 854-62. PMID 23303063 DOI: 10.1038/Npp.2012.251 |
0.801 |
|
| 2013 |
Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI. Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 299-305. PMID 23297076 DOI: 10.2967/jnumed.112.108688 |
0.334 |
|
| 2013 |
Lin H, Sassano MF, Roth BL, Shoichet BK. A pharmacological organization of G protein-coupled receptors. Nature Methods. 10: 140-6. PMID 23291723 DOI: 10.1038/Nmeth.2324 |
0.402 |
|
| 2013 |
Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C. Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. The American Journal of Pathology. 182: 776-85. PMID 23291213 DOI: 10.1016/J.Ajpath.2012.11.021 |
0.733 |
|
| 2013 |
Iversen L, Gibbons S, Treble R, Setola V, Huang XP, Roth BL. Neurochemical profiles of some novel psychoactive substances. European Journal of Pharmacology. 700: 147-51. PMID 23261499 DOI: 10.1016/J.Ejphar.2012.12.006 |
0.684 |
|
| 2013 |
Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorganic & Medicinal Chemistry. 21: 93-101. PMID 23218469 DOI: 10.1016/J.Bmc.2012.10.057 |
0.381 |
|
| 2013 |
Farrell MS, Roth BL. Pharmacosynthetics: Reimagining the pharmacogenetic approach. Brain Research. 1511: 6-20. PMID 23063887 DOI: 10.1016/j.brainres.2012.09.043 |
0.605 |
|
| 2013 |
Wu H, Li J, Fronczek FR, Ferreira D, Burandt CL, Setola V, Roth BL, Zjawiony JK. Labdane diterpenoids from Leonotis leonurus. Phytochemistry. 91: 229-35. PMID 22445074 DOI: 10.1016/J.Phytochem.2012.02.021 |
0.65 |
|
| 2013 |
Hasegawa E, Yanagisawa M, Roth B, Sakurai T, Mieda M. Restoration of orexin signaling in the dorsal raphe and locus coeruleus differntially ameliorate symptoms of narcoleptic mice Sleep Medicine. 14. DOI: 10.1016/J.Sleep.2013.11.342 |
0.328 |
|
| 2013 |
Sassano MF, Allen JA, Jin J, Setola V, Wetsel WC, Caron MG, Roth BL. D2 Functionally Selective Ligands: Novel Therapeutics? Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 105. DOI: 10.1016/B978-0-12-800044-1.00091-X |
0.584 |
|
| 2012 |
Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, ... ... Roth BL, et al. Automated design of ligands to polypharmacological profiles. Nature. 492: 215-20. PMID 23235874 DOI: 10.1038/Nature11691 |
0.649 |
|
| 2012 |
Roth BL, Marshall FH. NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family. Nature. 492: 57. PMID 23222609 DOI: 10.1038/492057a |
0.333 |
|
| 2012 |
Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE. trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. Beilstein Journal of Organic Chemistry. 8: 1705-9. PMID 23209503 DOI: 10.3762/Bjoc.8.194 |
0.464 |
|
| 2012 |
White KL, Roth BL. Psychotomimetic effects of kappa opioid receptor agonists. Biological Psychiatry. 72: 797-8. PMID 23083945 DOI: 10.1016/J.Biopsych.2012.08.014 |
0.38 |
|
| 2012 |
Zhu H, Urban DJ, Blashka J, McPheeters MT, Kroeze WK, Mieczkowski P, Overholser JC, Jurjus GJ, Dieter L, Mahajan GJ, Rajkowska G, Wang Z, Sullivan PF, Stockmeier CA, Roth BL. Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders. Plos One. 7: e43227. PMID 22912834 DOI: 10.1371/Journal.Pone.0043227 |
0.606 |
|
| 2012 |
Chen X, Sassano MF, Zheng L, Setola V, Chen M, Bai X, Frye SV, Wetsel WC, Roth BL, Jin J. Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. Journal of Medicinal Chemistry. 55: 7141-53. PMID 22845053 DOI: 10.1021/Jm300603Y |
0.702 |
|
| 2012 |
Mangin F, Dilly S, Joly B, Scuvée-Moreau J, Evans J, Setola V, Roth BL, Liégeois JF. Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. Bioorganic & Medicinal Chemistry Letters. 22: 4550-4. PMID 22738628 DOI: 10.1016/J.Bmcl.2012.05.119 |
0.708 |
|
| 2012 |
Gregori-Puigjané E, Setola V, Hert J, Crews BA, Irwin JJ, Lounkine E, Marnett L, Roth BL, Shoichet BK. Identifying mechanism-of-action targets for drugs and probes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11178-83. PMID 22711801 DOI: 10.1073/Pnas.1204524109 |
0.622 |
|
| 2012 |
Lin X, Huang XP, Chen G, Whaley R, Peng S, Wang Y, Zhang G, Wang SX, Wang S, Roth BL, Huang N. Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors. Journal of Medicinal Chemistry. 55: 5749-59. PMID 22694093 DOI: 10.1021/Jm300338M |
0.445 |
|
| 2012 |
Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 485: 395-9. PMID 22596163 DOI: 10.1038/Nature11085 |
0.419 |
|
| 2012 |
Hajjo R, Setola V, Roth BL, Tropsha A. Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers. Journal of Medicinal Chemistry. 55: 5704-19. PMID 22537153 DOI: 10.1021/Jm2011657 |
0.704 |
|
| 2012 |
Zhu XY, Etukala JR, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European Journal of Medicinal Chemistry. 53: 124-32. PMID 22520153 DOI: 10.1016/J.Ejmech.2012.03.042 |
0.701 |
|
| 2012 |
Li J, Fronczek FR, Ferreira D, Burandt CL, Setola V, Roth BL, Zjawiony JK. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products. 75: 728-34. PMID 22475308 DOI: 10.1021/Np3000156 |
0.624 |
|
| 2012 |
Garner AR, Rowland DC, Hwang SY, Baumgaertel K, Roth BL, Kentros C, Mayford M. Generation of a synthetic memory trace. Science (New York, N.Y.). 335: 1513-6. PMID 22442487 DOI: 10.1126/Science.1214985 |
0.31 |
|
| 2012 |
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, et al. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-32. PMID 22437504 DOI: 10.1038/Nature10939 |
0.403 |
|
| 2012 |
Peprah K, Zhu XY, Eyunni SV, Etukala JR, Setola V, Roth BL, Ablordeppey SY. Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol. Bioorganic & Medicinal Chemistry. 20: 1671-8. PMID 22336245 DOI: 10.1016/J.Bmc.2012.01.022 |
0.674 |
|
| 2012 |
Lee HM, Roth BL. Hallucinogen actions on human brain revealed. Proceedings of the National Academy of Sciences of the United States of America. 109: 1820-1. PMID 22308478 DOI: 10.1073/pnas.1121358109 |
0.493 |
|
| 2012 |
Peprah K, Zhu XY, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents. Bioorganic & Medicinal Chemistry. 20: 1291-7. PMID 22245230 DOI: 10.1016/J.Bmc.2011.12.019 |
0.685 |
|
| 2012 |
Kim MK, Lee HS, Kim S, Cho SY, Roth BL, Chong Y, Choo H. 4-Aminoethylpiperazinyl aryl ketones with 5-HTâ‚A/5-HT₇ selectivity. Bioorganic & Medicinal Chemistry. 20: 1139-48. PMID 22196512 DOI: 10.1016/j.bmc.2011.11.005 |
0.384 |
|
| 2012 |
Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 481: 185-9. PMID 22190039 DOI: 10.1038/Nature10726 |
0.777 |
|
| 2012 |
Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK. Chemical informatics and target identification in a zebrafish phenotypic screen. Nature Chemical Biology. 8: 144-6. PMID 22179068 DOI: 10.1038/Nchembio.732 |
0.598 |
|
| 2012 |
Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 17, (6727-6732) DOI: 10.1073/pnas.1016558108) Proceedings of the National Academy of Sciences of the United States of America. 109: 15526-15527. DOI: 10.1073/Pnas.1213952109 |
0.653 |
|
| 2012 |
Goldsmith JR, Chanona EP, Yadav PN, Whistler JL, Roth B, Jobin C. Sa1939 Intestinal Epithelial Cell (IEC)-Derived Mu-Opioid Signaling is Protective Against Ischemia Reperfusion (I/R) Induced Injury Gastroenterology. 142: S-364. DOI: 10.1016/S0016-5085(12)61373-0 |
0.585 |
|
| 2012 |
Yadav PN, Whistler J, Roth BL. ISDN2012_0285: Cellular mechanisms of salvinorin A action
in vivo International Journal of Developmental Neuroscience. 30: 689-689. DOI: 10.1016/J.Ijdevneu.2012.10.056 |
0.583 |
|
| 2011 |
Allen JA, Yadav PN, Setola V, Farrell M, Roth BL. Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo. Translational Psychiatry. 1: e33. PMID 22832607 DOI: 10.1038/Tp.2011.35 |
0.822 |
|
| 2011 |
Chen G, Cho SJ, Huang XP, Jensen NH, Svennebring A, Sassano MF, Roth BL, Kozikowski AP. Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity. Acs Medicinal Chemistry Letters. 2: 929-932. PMID 22778800 DOI: 10.1021/Ml200206Z |
0.434 |
|
| 2011 |
Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, et al. Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences. 1236: 30-43. PMID 22032400 DOI: 10.1111/J.1749-6632.2011.06216.X |
0.678 |
|
| 2011 |
Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, ... ... Roth BL, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proceedings of the National Academy of Sciences of the United States of America. 108: 18488-93. PMID 22025698 DOI: 10.1073/Pnas.1104807108 |
0.8 |
|
| 2011 |
Carlsson J, Coleman RG, Setola V, Irwin JJ, Fan H, Schlessinger A, Sali A, Roth BL, Shoichet BK. Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nature Chemical Biology. 7: 769-78. PMID 21926995 DOI: 10.1038/Nchembio.662 |
0.66 |
|
| 2011 |
Yadav PN, Kroeze WK, Farrell MS, Roth BL. Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo. The Journal of Pharmacology and Experimental Therapeutics. 339: 99-105. PMID 21737536 DOI: 10.1124/jpet.111.183780 |
0.829 |
|
| 2011 |
Whitby LR, Ando Y, Setola V, Vogt PK, Roth BL, Boger DL. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions. Journal of the American Chemical Society. 133: 10184-94. PMID 21609016 DOI: 10.1021/Ja201878V |
0.669 |
|
| 2011 |
Hutcheson JD, Setola V, Roth BL, Merryman WD. Serotonin receptors and heart valve disease--it was meant 2B. Pharmacology & Therapeutics. 132: 146-57. PMID 21440001 DOI: 10.1016/J.Pharmthera.2011.03.008 |
0.691 |
|
| 2011 |
Rogan SC, Roth BL. Remote control of neuronal signaling. Pharmacological Reviews. 63: 291-315. PMID 21415127 DOI: 10.1124/Pr.110.003020 |
0.791 |
|
| 2011 |
Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proceedings of the National Academy of Sciences of the United States of America. 108: 6727-32. PMID 21368188 DOI: 10.1073/Pnas.1016558108 |
0.684 |
|
| 2011 |
Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. The Journal of Clinical Investigation. 121: 1424-8. PMID 21364278 DOI: 10.1172/Jci46229 |
0.754 |
|
| 2011 |
Roth BL. Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation. Neuropharmacology. 61: 348-54. PMID 21288474 DOI: 10.1016/j.neuropharm.2011.01.012 |
0.478 |
|
| 2011 |
McKenna DJ, Ruiz JM, Hoye TR, Roth BL, Shoemaker AT. Receptor screening technologies in the evaluation of Amazonian ethnomedicines with potential applications to cognitive deficits. Journal of Ethnopharmacology. 134: 475-92. PMID 21232588 DOI: 10.1016/J.Jep.2010.12.037 |
0.4 |
|
| 2011 |
Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF. Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nature Neuroscience. 14: 22-4. PMID 21131952 DOI: 10.1038/Nn.2703 |
0.377 |
|
| 2011 |
Fichna J, Lewellyn K, Yan F, Roth BL, Zjawiony JK. Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids. Bioorganic & Medicinal Chemistry Letters. 21: 160-3. PMID 21115248 DOI: 10.1016/J.Bmcl.2010.11.046 |
0.467 |
|
| 2011 |
Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, ... Roth BL, et al. The presynaptic component of the serotonergic system is required for clozapine's efficacy. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 638-51. PMID 21048700 DOI: 10.1038/Npp.2010.195 |
0.804 |
|
| 2011 |
Allen JA, Roth BL. Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annual Review of Pharmacology and Toxicology. 51: 117-44. PMID 20868273 DOI: 10.1146/annurev-pharmtox-010510-100553 |
0.742 |
|
| 2011 |
Davies MA, Conley Y, Roth BL. Functional SNPs in genes encoding the 5-HT2A receptor modify the affinity and potency of several atypical antipsychotic drugs. Biological Research For Nursing. 13: 55-60. PMID 20097665 DOI: 10.1177/1099800409358760 |
0.441 |
|
| 2011 |
Fichna J, Lewellyn K, Yan F, Roth BL, Zjawiony JK. Synthesis and in vitro characterization of new salvinorin a analogs incorporating natural amino acids Pharmacological Reports. 63: 232-233. DOI: 10.1016/S1734-1140(11)70453-4 |
0.365 |
|
| 2010 |
Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL. Identification of human Ether-Ã -go-go related gene modulators by three screening platforms in an academic drug-discovery setting. Assay and Drug Development Technologies. 8: 727-42. PMID 21158687 DOI: 10.1089/Adt.2010.0331 |
0.63 |
|
| 2010 |
Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. Journal of Medicinal Chemistry. 53: 7573-86. PMID 20958049 DOI: 10.1021/Jm100600Y |
0.695 |
|
| 2010 |
Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorganic & Medicinal Chemistry. 18: 7548-64. PMID 20888240 DOI: 10.1016/J.Bmc.2010.08.049 |
0.363 |
|
| 2010 |
Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J. N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands. Acs Medicinal Chemistry Letters. 1: 189-193. PMID 20729985 DOI: 10.1021/Ml100040T |
0.676 |
|
| 2010 |
Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, et al. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8. PMID 20727364 DOI: 10.1016/J.Neuropharm.2010.08.011 |
0.354 |
|
| 2010 |
Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B. Bioorganic & Medicinal Chemistry Letters. 20: 5488-90. PMID 20692833 DOI: 10.1016/J.Bmcl.2010.07.074 |
0.671 |
|
| 2010 |
Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. American Journal of Physiology. Cell Physiology. 299: C654-64. PMID 20573995 DOI: 10.1152/Ajpcell.00441.2009 |
0.638 |
|
| 2010 |
Kozikowski AP, Cho SJ, Jensen NH, Allen JA, Svennebring AM, Roth BL. HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia. Chemmedchem. 5: 1221-5. PMID 20533502 DOI: 10.1002/Cmdc.201000186 |
0.772 |
|
| 2010 |
Dong S, Allen JA, Farrell M, Roth BL. A chemical-genetic approach for precise spatio-temporal control of cellular signaling. Molecular Biosystems. 6: 1376-80. PMID 20532295 DOI: 10.1039/C002568M |
0.775 |
|
| 2010 |
Ozawa A, Lindberg I, Roth B, Kroeze WK. Deorphanization of novel peptides and their receptors. The Aaps Journal. 12: 378-84. PMID 20446073 DOI: 10.1208/S12248-010-9198-9 |
0.306 |
|
| 2010 |
Morabito MV, Abbas AI, Hood JL, Kesterson RA, Jacobs MM, Kump DS, Hachey DL, Roth BL, Emeson RB. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiology of Disease. 39: 169-80. PMID 20394819 DOI: 10.1016/J.Nbd.2010.04.004 |
0.745 |
|
| 2010 |
Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nature Neuroscience. 13: 622-9. PMID 20383137 DOI: 10.1038/Nn.2529 |
0.787 |
|
| 2010 |
Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, Roth BL, Cohen BM, Carlezon WA. Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats. Psychopharmacology. 210: 263-74. PMID 20358363 DOI: 10.1007/S00213-010-1834-7 |
0.383 |
|
| 2010 |
Dong S, Rogan SC, Roth BL. Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs. Nature Protocols. 5: 561-73. PMID 20203671 DOI: 10.1038/Nprot.2009.239 |
0.81 |
|
| 2010 |
Abbas AI, Urban DJ, Jensen NH, Farrell MS, Kroeze WK, Mieczkowski P, Wang Z, Roth BL. Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method. Nucleic Acids Research. 38: e118. PMID 20185571 DOI: 10.1093/Nar/Gkq107 |
0.814 |
|
| 2010 |
Glennon RA, Siripurapu U, Roth BL, Kolanos R, Bondarev ML, Sikazwe D, Lee M, Dukat M. The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs. Current Topics in Medicinal Chemistry. 10: 579-95. PMID 20166945 DOI: 10.2174/156802610791111542 |
0.462 |
|
| 2010 |
Farrell M, Roth BL. Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 851-2. PMID 20145632 DOI: 10.1038/Npp.2009.206 |
0.513 |
|
| 2010 |
Strachan RT, Allen JA, Sheffler DJ, Roth BL. p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling. Biochemistry. 49: 2657-71. PMID 20136148 DOI: 10.1021/bi901921k |
0.83 |
|
| 2010 |
McGovern DL, Mosier PD, Roth BL, Westkaemper RB. CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity. Journal of Molecular Graphics & Modelling. 28: 612-25. PMID 20083418 DOI: 10.1016/J.Jmgm.2009.12.008 |
0.398 |
|
| 2010 |
Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86. PMID 20074611 DOI: 10.1016/J.Pnpbp.2010.01.004 |
0.353 |
|
| 2010 |
Pei Y, Dong S, Roth BL. Generation of designer receptors exclusively activated by designer drugs (DREADDs) using directed molecular evolution. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.33. PMID 20066658 DOI: 10.1002/0471142301.ns0433s50 |
0.433 |
|
| 2010 |
Shah JR, Mosier PD, Peddi S, Roth BL, Westkaemper RB. 9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites. Bioorganic & Medicinal Chemistry Letters. 20: 935-8. PMID 20045641 DOI: 10.1016/J.Bmcl.2009.12.064 |
0.434 |
|
| 2010 |
Strachan RT, Sciaky N, Cronan MR, Kroeze WK, Roth BL. Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity. Molecular Pharmacology. 77: 327-38. PMID 19933401 DOI: 10.1124/Mol.109.061440 |
0.483 |
|
| 2010 |
Roth BL, Rogan SC. Neuropharmacological Profiles of Antipsychotic Drugs Dopamine Handbook. DOI: 10.1093/acprof:oso/9780195373035.003.0037 |
0.735 |
|
| 2010 |
Graulich A, Ĺonard M, Ŕsimont M, Huang XP, Roth BL, Lígeois JF. Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies Australian Journal of Chemistry. 63: 56-67. DOI: 10.1071/CH09353 |
0.432 |
|
| 2009 |
Nichols CD, Roth BL. Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Frontiers in Molecular Neuroscience. 2: 16. PMID 19893765 DOI: 10.3389/neuro.02.016.2009 |
0.434 |
|
| 2009 |
Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P. Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 19575-80. PMID 19889983 DOI: 10.1073/Pnas.0905884106 |
0.76 |
|
| 2009 |
Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, ... ... Roth BL, et al. Predicting new molecular targets for known drugs. Nature. 462: 175-81. PMID 19881490 DOI: 10.1038/Nature08506 |
0.809 |
|
| 2009 |
Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 19197-202. PMID 19858481 DOI: 10.1073/Pnas.0906593106 |
0.304 |
|
| 2009 |
Shah JR, Mosier PD, Roth BL, Kellogg GE, Westkaemper RB. Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorganic & Medicinal Chemistry. 17: 6496-504. PMID 19700330 DOI: 10.1016/J.Bmc.2009.08.016 |
0.464 |
|
| 2009 |
Allen JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Molecular Pharmacology. 76: 1082-93. PMID 19696145 DOI: 10.1124/Mol.109.060160 |
0.782 |
|
| 2009 |
Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annual Review of Medicine. 60: 355-66. PMID 19630576 DOI: 10.1146/Annurev.Med.60.042307.110802 |
0.625 |
|
| 2009 |
Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO, Roth BL. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron. 63: 27-39. PMID 19607790 DOI: 10.1016/J.Neuron.2009.06.014 |
0.787 |
|
| 2009 |
Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL. Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment. Molecular Pharmacology. 76: 710-22. PMID 19570945 DOI: 10.1124/Mol.109.058057 |
0.82 |
|
| 2009 |
Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry. 48: 6898-908. PMID 19555087 DOI: 10.1021/Bi900605N |
0.756 |
|
| 2009 |
Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL. PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7124-36. PMID 19494135 DOI: 10.1523/Jneurosci.1090-09.2009 |
0.825 |
|
| 2009 |
Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). The Journal of Biological Chemistry. 284: 19402-11. PMID 19478087 DOI: 10.1074/Jbc.M109.024711 |
0.793 |
|
| 2009 |
Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. Journal of Medicinal Chemistry. 52: 3892-901. PMID 19469546 DOI: 10.1021/Jm9002704 |
0.664 |
|
| 2009 |
Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology. 205: 119-28. PMID 19337725 DOI: 10.1007/S00213-009-1521-8 |
0.781 |
|
| 2009 |
Cho SJ, Jensen NH, Kurome T, Kadari S, Manzano ML, Malberg JE, Caldarone B, Roth BL, Kozikowski AP. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. Journal of Medicinal Chemistry. 52: 1885-902. PMID 19284718 DOI: 10.1021/jm801354e |
0.439 |
|
| 2009 |
Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Journal of Medicinal Chemistry. 52: 1795-8. PMID 19275170 DOI: 10.1021/Jm801652D |
0.345 |
|
| 2009 |
Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. The Journal of Pharmacology and Experimental Therapeutics. 329: 738-46. PMID 19197004 DOI: 10.1124/Jpet.108.146142 |
0.661 |
|
| 2009 |
Sikazwe DM, Nkansah NT, Altundas R, Zhu XY, Roth BL, Setola V, Ablordeppey SY. Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. Bioorganic & Medicinal Chemistry. 17: 1716-23. PMID 19155177 DOI: 10.1016/J.Bmc.2008.12.054 |
0.689 |
|
| 2009 |
Strachan RT, Sheffler DJ, Willard B, Kinter M, Kiselar JG, Roth BL. Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling. The Journal of Biological Chemistry. 284: 5557-73. PMID 19103592 DOI: 10.1074/Jbc.M805705200 |
0.73 |
|
| 2008 |
Bikbulatov RV, Stewart J, Jin W, Yan F, Roth BL, Ferreira D, Zjawiony JK. Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure. Tetrahedron Letters. 49: 937-940. PMID 19197341 DOI: 10.1016/J.Tetlet.2007.12.041 |
0.503 |
|
| 2008 |
Pei Y, Rogan SC, Yan F, Roth BL. Engineered GPCRs as tools to modulate signal transduction. Physiology (Bethesda, Md.). 23: 313-21. PMID 19074739 DOI: 10.1152/Physiol.00025.2008 |
0.821 |
|
| 2008 |
Abbas A, Roth BL. Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Expert Opinion On Pharmacotherapy. 9: 3251-9. PMID 19040345 DOI: 10.1517/14656560802532707 |
0.71 |
|
| 2008 |
Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. Journal of Medicinal Chemistry. 51: 6808-28. PMID 18847250 DOI: 10.1021/Jm800771X |
0.486 |
|
| 2008 |
Abbas A, Roth BL. Protein engineering: electrifying cell receptors. Nature Nanotechnology. 3: 587-8. PMID 18838995 DOI: 10.1038/Nnano.2008.292 |
0.729 |
|
| 2008 |
Ma ZZ, Xu W, Jensen NH, Roth BL, Liu-Chen LY, Lee DY. Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules (Basel, Switzerland). 13: 2303-12. PMID 18830156 DOI: 10.3390/molecules13092303 |
0.349 |
|
| 2008 |
Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, et al. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry. 16: 8853-62. PMID 18790643 DOI: 10.1016/J.Bmc.2008.08.072 |
0.352 |
|
| 2008 |
Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 18: 5268-71. PMID 18774714 DOI: 10.1016/J.Bmcl.2008.08.059 |
0.432 |
|
| 2008 |
Basura GJ, Abbas AI, O'Donohue H, Lauder JM, Roth BL, Walker PD, Manis PB. Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex. Hearing Research. 244: 45-50. PMID 18718516 DOI: 10.1016/J.Heares.2008.07.009 |
0.767 |
|
| 2008 |
Jensen NH, Roth BL. Massively parallel screening of the receptorome. Combinatorial Chemistry & High Throughput Screening. 11: 420-6. PMID 18673270 DOI: 10.2174/138620708784911483 |
0.458 |
|
| 2008 |
Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nature Methods. 5: 673-8. PMID 18668035 DOI: 10.1038/Nmeth.1232 |
0.394 |
|
| 2008 |
Allen JA, Yadav PN, Roth BL. Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases. Neuropharmacology. 55: 961-8. PMID 18640136 DOI: 10.1016/j.neuropharm.2008.06.048 |
0.828 |
|
| 2008 |
Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). Molecular Pharmacology. 74: 1119-31. PMID 18628403 DOI: 10.1124/Mol.108.049353 |
0.428 |
|
| 2008 |
Ablordeppey SY, Altundas R, Bricker B, Zhu XY, Kumar EV, Jackson T, Khan A, Roth BL. Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. Bioorganic & Medicinal Chemistry. 16: 7291-301. PMID 18595716 DOI: 10.1016/j.bmc.2008.06.030 |
0.451 |
|
| 2008 |
Conn PJ, Roth BL. Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2048-60. PMID 18216778 DOI: 10.1038/sj.npp.1301638 |
0.317 |
|
| 2008 |
Yan F, Mosier PD, Westkaemper RB, Roth BL. Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors. Biochemistry. 47: 1567-78. PMID 18205395 DOI: 10.1021/Bi701476B |
0.485 |
|
| 2008 |
Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. Journal of Medicinal Chemistry. 51: 603-11. PMID 18201064 DOI: 10.1021/Jm070910S |
0.461 |
|
| 2008 |
Abbas A, Roth BL. Arresting serotonin. Proceedings of the National Academy of Sciences of the United States of America. 105: 831-2. PMID 18195368 DOI: 10.1073/Pnas.0711335105 |
0.772 |
|
| 2008 |
Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2303-12. PMID 18059438 DOI: 10.1038/Sj.Npp.1301646 |
0.425 |
|
| 2008 |
Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. The Journal of Pharmacology and Experimental Therapeutics. 324: 188-95. PMID 17951511 DOI: 10.1124/Jpet.107.129023 |
0.403 |
|
| 2008 |
Xia Z, Roth BL. Novel mechanisms of drug treatment in psychiatry Tthe Medical Basis of Psychiatry: Third Edition. 519-534. DOI: 10.1007/978-1-59745-252-6_30 |
0.577 |
|
| 2007 |
Svenningsson P, Bateup H, Qi H, Takamiya K, Huganir RL, Spedding M, Roth BL, McEwen BS, Greengard P. Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine. The European Journal of Neuroscience. 26: 3509-17. PMID 18088278 DOI: 10.1111/J.1460-9568.2007.05952.X |
0.325 |
|
| 2007 |
Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C. Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes. Bioorganic & Medicinal Chemistry. 15: 7626-37. PMID 17889543 DOI: 10.1016/j.bmc.2007.09.003 |
0.337 |
|
| 2007 |
Gray JA, Roth BL. The pipeline and future of drug development in schizophrenia. Molecular Psychiatry. 12: 904-22. PMID 17667958 DOI: 10.1038/sj.mp.4002062 |
0.487 |
|
| 2007 |
Gray JA, Roth BL. Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophrenia Bulletin. 33: 1100-19. PMID 17617664 DOI: 10.1093/schbul/sbm074 |
0.502 |
|
| 2007 |
Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proceedings of the National Academy of Sciences of the United States of America. 104: 5163-8. PMID 17360345 DOI: 10.1073/pnas.0700293104 |
0.428 |
|
| 2007 |
Bikbulatov RV, Yan F, Roth BL, Zjawiony JK. Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorganic & Medicinal Chemistry Letters. 17: 2229-32. PMID 17303418 DOI: 10.1016/J.Bmcl.2007.01.100 |
0.551 |
|
| 2007 |
Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nature Biotechnology. 25: 197-206. PMID 17287757 DOI: 10.1038/Nbt1284 |
0.363 |
|
| 2007 |
Carato P, Graulich A, Jensen N, Roth BL, Liégeois JF. Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1565-9. PMID 17254782 DOI: 10.1016/j.bmcl.2006.12.096 |
0.458 |
|
| 2007 |
Carato P, Graulich A, Jensen N, Roth BL, Liégeois JF. Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1570-4. PMID 17251022 DOI: 10.1016/j.bmcl.2006.12.106 |
0.374 |
|
| 2007 |
Nyandege A, Kolanos R, Roth BL, Glennon RA. Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1691-4. PMID 17239595 DOI: 10.1016/J.Bmcl.2006.12.089 |
0.366 |
|
| 2007 |
Roth BL. Drugs and valvular heart disease. The New England Journal of Medicine. 356: 6-9. PMID 17202450 DOI: 10.1056/NEJMp068265 |
0.323 |
|
| 2007 |
Vortherms TA, Mosier PD, Westkaemper RB, Roth BL. Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. The Journal of Biological Chemistry. 282: 3146-56. PMID 17121830 DOI: 10.1074/Jbc.M609264200 |
0.436 |
|
| 2007 |
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/Jpet.106.104463 |
0.467 |
|
| 2007 |
Yan F, Roth B. G-protein alpha subunits differentially alter the conformation of kappa opioid receptor The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A429-C |
0.459 |
|
| 2006 |
Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. The Journal of Organic Chemistry. 71: 8934-45. PMID 17081025 DOI: 10.1021/jo061758p |
0.308 |
|
| 2006 |
Vortherms TA, Roth BL. Salvinorin A: from natural product to human therapeutics. Molecular Interventions. 6: 257-65. PMID 17035666 DOI: 10.1124/mi.6.5.7 |
0.363 |
|
| 2006 |
Kolanos R, Dukat M, Roth BL, Glennon RA. Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5832-5. PMID 16945532 DOI: 10.1016/J.Bmcl.2006.08.068 |
0.404 |
|
| 2006 |
Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology. 188: 244-51. PMID 16915381 DOI: 10.1007/S00213-006-0490-4 |
0.464 |
|
| 2006 |
Sikazwe D, Bondarev ML, Dukat M, Rangisetty JB, Roth BL, Glennon RA. Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. Journal of Medicinal Chemistry. 49: 5217-25. PMID 16913710 DOI: 10.1021/Jm060469Q |
0.444 |
|
| 2006 |
Strachan RT, Ferrara G, Roth BL. Screening the receptorome: an efficient approach for drug discovery and target validation. Drug Discovery Today. 11: 708-16. PMID 16846798 DOI: 10.1016/j.drudis.2006.06.012 |
0.332 |
|
| 2006 |
Kroeze WK, Roth BL. Screening the receptorome. Journal of Psychopharmacology (Oxford, England). 20: 41-6. PMID 16785269 DOI: 10.1177/1359786806066045 |
0.358 |
|
| 2006 |
Stewart DJ, Fahmy H, Roth BL, Yan F, Zjawiony JK. Bioisosteric modification of salvinorin A, a potent and selective kappa-opioid receptor agonist. Arzneimittel-Forschung. 56: 269-75. PMID 16724512 DOI: 10.1055/S-0031-1296720 |
0.502 |
|
| 2006 |
Roth BL, Kroeze WK. Screening the receptorome yields validated molecular targets for drug discovery. Current Pharmaceutical Design. 12: 1785-95. PMID 16712488 DOI: 10.2174/138161206776873680 |
0.394 |
|
| 2006 |
Siripurapu U, Kolanos R, Dukat M, Roth BL, Glennon RA. Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 3793-6. PMID 16709453 DOI: 10.1016/J.Bmcl.2006.04.094 |
0.434 |
|
| 2006 |
Ansonoff MA, Zhang J, Czyzyk T, Rothman RB, Stewart J, Xu H, Zjwiony J, Siebert DJ, Yang F, Roth BL, Pintar JE. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 318: 641-8. PMID 16672569 DOI: 10.1124/Jpet.106.101998 |
0.401 |
|
| 2006 |
Ablordeppey SY, Lyles-Eggleston M, Bricker B, Zhang W, Zhu X, Goodman C, Roth BL. Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol. Bioorganic & Medicinal Chemistry Letters. 16: 3219-23. PMID 16621538 DOI: 10.1016/j.bmcl.2006.03.057 |
0.387 |
|
| 2006 |
Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 103: 4717-22. PMID 16537434 DOI: 10.1073/Pnas.0600585103 |
0.721 |
|
| 2006 |
Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. Journal of Medicinal Chemistry. 49: 1080-100. PMID 16451073 DOI: 10.1021/Jm050570F |
0.368 |
|
| 2006 |
Kushwaha N, Harwood SC, Wilson AM, Berger M, Tecott LH, Roth BL, Albert PR. Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. Molecular Pharmacology. 69: 1518-26. PMID 16410407 DOI: 10.1124/Mol.105.019844 |
0.364 |
|
| 2006 |
Davies MA, Setola V, Strachan RT, Sheffler DJ, Salay E, Hufeisen SJ, Roth BL. Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies. The Pharmacogenomics Journal. 6: 42-51. PMID 16314884 DOI: 10.1038/sj.tpj.6500342 |
0.792 |
|
| 2006 |
Abbas A, Roth B. Progress towards better understanding and treatment of major psychiatric illnesses. Drug Discovery Today. 10: 960-2. PMID 16023053 DOI: 10.1016/s1359-6446(05)03523-3 |
0.646 |
|
| 2006 |
Pehek EA, Nocjar C, Roth BL, Byrd TA, Mabrouk OS. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 265-77. PMID 15999145 DOI: 10.1038/sj.npp.1300819 |
0.412 |
|
| 2006 |
Gray JA, Roth BL. Developing selectively nonselective drugs for treating CNS disorders Drug Discovery Today: Therapeutic Strategies. 3: 413-419. DOI: 10.1016/j.ddstr.2006.11.009 |
0.51 |
|
| 2005 |
Setola V, Roth BL. Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. Expert Opinion On Drug Metabolism & Toxicology. 1: 377-87. PMID 16863450 DOI: 10.1517/17425255.1.3.377 |
0.673 |
|
| 2005 |
Munro TA, Goetchius GW, Roth BL, Vortherms TA, Rizzacasa MA. Autoxidation of salvinorin A under basic conditions. The Journal of Organic Chemistry. 70: 10057-61. PMID 16292839 DOI: 10.1021/Jo051813E |
0.332 |
|
| 2005 |
Søndergaard K, Kristensen JL, Palner M, Gillings N, Knudsen GM, Roth BL, Begtrup M. Synthesis and binding studies of 2-arylapomorphines. Organic & Biomolecular Chemistry. 3: 4077-81. PMID 16267586 DOI: 10.1039/b507195j |
0.374 |
|
| 2005 |
O'Connor KA, Roth BL. Screening the receptorome for plant-based psychoactive compounds. Life Sciences. 78: 506-11. PMID 16213532 DOI: 10.1016/j.lfs.2005.09.002 |
0.345 |
|
| 2005 |
Pullagurla M, Siripurapu U, Kolanos R, Bondarev ML, Dukat M, Setola V, Roth BL, Glennon RA. Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 15: 5298-302. PMID 16183286 DOI: 10.1016/J.Bmcl.2005.08.059 |
0.69 |
|
| 2005 |
Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. Journal of Combinatorial Chemistry. 7: 673-81. PMID 16153061 DOI: 10.1021/Cc050064B |
0.446 |
|
| 2005 |
Huang Y, Bae SA, Roth BL, Laruelle M. Synthesis of potent and selective serotonin 5-HT1B receptor ligands. Bioorganic & Medicinal Chemistry Letters. 15: 4786-9. PMID 16143528 DOI: 10.1016/j.bmcl.2005.07.024 |
0.469 |
|
| 2005 |
Roth BL. Receptor systems: will mining the receptorome yield novel targets for pharmacotherapy? Pharmacology & Therapeutics. 108: 59-64. PMID 16083965 DOI: 10.1016/j.pharmthera.2005.06.013 |
0.339 |
|
| 2005 |
Sard H, Kumaran G, Morency C, Roth BL, Toth BA, He P, Shuster L. SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorganic & Medicinal Chemistry Letters. 15: 4555-9. PMID 16061378 DOI: 10.1016/j.bmcl.2005.06.104 |
0.429 |
|
| 2005 |
Abate C, Kolanos R, Dukat M, Setola V, Roth BL, Glennon RA. Interaction of chiral MS-245 analogs at h5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters. 15: 3510-3. PMID 15990303 DOI: 10.1016/J.Bmcl.2005.05.092 |
0.684 |
|
| 2005 |
Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors. Biochemistry. 44: 8643-51. PMID 15952771 DOI: 10.1021/Bi050490D |
0.741 |
|
| 2005 |
Setola V, Dukat M, Glennon RA, Roth BL. Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor. Molecular Pharmacology. 68: 20-33. PMID 15831837 DOI: 10.1124/Mol.104.009266 |
0.696 |
|
| 2005 |
Kolanos R, Siripurapu U, Pullagurla M, Riaz M, Setola V, Roth BL, Dukat M, Glennon RA. Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 15: 1987-91. PMID 15808453 DOI: 10.1016/J.Bmcl.2005.02.070 |
0.654 |
|
| 2005 |
Davies MA, Compton-Toth BA, Hufeisen SJ, Meltzer HY, Roth BL. The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions? Psychopharmacology. 178: 451-60. PMID 15765260 DOI: 10.1007/S00213-004-2017-1 |
0.395 |
|
| 2005 |
Rothman RB, Blough BE, Woolverton WL, Anderson KG, Negus SS, Mello NK, Roth BL, Baumann MH. Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration. The Journal of Pharmacology and Experimental Therapeutics. 313: 1361-9. PMID 15761112 DOI: 10.1124/Jpet.104.082503 |
0.34 |
|
| 2005 |
Lee M, Rangisetty JB, Pullagurla MR, Dukat M, Setola V, Roth BL, Glennon RA. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorganic & Medicinal Chemistry Letters. 15: 1707-11. PMID 15745826 DOI: 10.1016/J.Bmcl.2005.01.031 |
0.706 |
|
| 2005 |
Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 45: 489-96. PMID 15721235 DOI: 10.1016/J.Neuron.2005.01.041 |
0.329 |
|
| 2005 |
Munro TA, Rizzacasa MA, Roth BL, Toth BA, Yan F. Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. Journal of Medicinal Chemistry. 48: 345-8. PMID 15658846 DOI: 10.1021/Jm049438Q |
0.517 |
|
| 2005 |
Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity. Bioorganic & Medicinal Chemistry. 13: 197-209. PMID 15582465 DOI: 10.1016/j.bmc.2004.09.042 |
0.416 |
|
| 2005 |
Pullagurla M, Dukat M, Roth BL, Setola V, Glennon RA. 5-Azatryptamine analogs as h5-HT6 serotonin receptor ligands Medicinal Chemistry Research. 14: 1-18. DOI: 10.1007/S00044-004-0121-8 |
0.694 |
|
| 2004 |
Roth BL, Xia Z. Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis. Critical Reviews in Neurobiology. 16: 229-36. PMID 15862107 DOI: 10.1615/CritRevNeurobiol.v16.i4.10 |
0.71 |
|
| 2004 |
Davies MA, Sheffler DJ, Roth BL. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. Cns Drug Reviews. 10: 317-36. PMID 15592581 DOI: 10.1111/J.1527-3458.2004.Tb00030.X |
0.674 |
|
| 2004 |
Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science (New York, N.Y.). 306: 1380-3. PMID 15550673 DOI: 10.1126/Science.1103492 |
0.631 |
|
| 2004 |
Yan F, Roth BL. Salvinorin A: a novel and highly selective kappa-opioid receptor agonist. Life Sciences. 75: 2615-9. PMID 15369697 DOI: 10.1016/J.Lfs.2004.07.008 |
0.512 |
|
| 2004 |
Quirk PL, Rao S, Roth BL, Siegel RE. Three putative N-glycosylation sites within the murine 5-HT3A receptor sequence affect plasma membrane targeting, ligand binding, and calcium influx in heterologous mammalian cells. Journal of Neuroscience Research. 77: 498-506. PMID 15264219 DOI: 10.1002/Jnr.20185 |
0.402 |
|
| 2004 |
Roth BL, Hanizavareh SM, Blum AE. Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology. 174: 17-24. PMID 15205874 DOI: 10.1007/s00213-003-1683-8 |
0.337 |
|
| 2004 |
Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. The Journal of Biological Chemistry. 279: 34614-23. PMID 15190056 DOI: 10.1074/Jbc.M404673200 |
0.788 |
|
| 2004 |
Roth BL, Lopez E, Beischel S, Westkaemper RB, Evans JM. Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacology & Therapeutics. 102: 99-110. PMID 15163592 DOI: 10.1016/j.pharmthera.2004.03.004 |
0.318 |
|
| 2004 |
Petrie KA, Bubser M, Casey CD, Davis MD, Roth BL, Deutch AY. The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1878-88. PMID 15150532 DOI: 10.1038/Sj.Npp.1300494 |
0.333 |
|
| 2004 |
Peddi S, Roth BL, Glennon RA, Westkaemper RB. Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA). Bioorganic & Medicinal Chemistry Letters. 14: 2279-83. PMID 15081025 DOI: 10.1016/J.BMCL.2004.02.014 |
0.447 |
|
| 2004 |
Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Reviews. Drug Discovery. 3: 353-9. PMID 15060530 DOI: 10.1038/nrd1346 |
0.65 |
|
| 2004 |
Chang-Fong J, Rangisetty JB, Dukat M, Setola V, Raffay T, Roth B, Glennon RA. 1,2,3,4-Tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands Bioorganic and Medicinal Chemistry Letters. 14: 1961-1964. PMID 15050637 DOI: 10.1016/J.Bmcl.2004.01.071 |
0.68 |
|
| 2004 |
O'Sullivan GJ, Roth BL, Kinsella A, Waddington JL. SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography. European Journal of Pharmacology. 486: 273-80. PMID 14985049 DOI: 10.1016/j.ejphar.2004.01.004 |
0.363 |
|
| 2004 |
Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. The Journal of Pharmacology and Experimental Therapeutics. 308: 1197-203. PMID 14718611 DOI: 10.1124/jpet.103.059394 |
0.419 |
|
| 2004 |
Roth BL, Kroeze WK, Sheffler DJ. Fast dissociation rates predict neither efficacy nor lack of side-effects Nature Reviews Drug Discovery. 3: 894-894. DOI: 10.1038/Nrd1346-C2 |
0.613 |
|
| 2003 |
Peddi S, Roth BL, Glennon RA, Westkaemper RB. Spiro[9,10-dihydroanthracene]-9,3'-pyrrolidine-a structurally unique tetracyclic 5-HT2A receptor antagonist. European Journal of Pharmacology. 482: 335-7. PMID 14660041 DOI: 10.1016/J.Ejphar.2003.09.059 |
0.465 |
|
| 2003 |
Setola V, Roth BL. Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants. Molecular Pharmacology. 64: 1277-8. PMID 14645656 DOI: 10.1124/Mol.64.6.1277 |
0.666 |
|
| 2003 |
Xia Z, Hufeisen SJ, Gray JA, Roth BL. The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience. 122: 907-20. PMID 14643760 DOI: 10.1016/S0306-4522(03)00589-X |
0.758 |
|
| 2003 |
Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. Journal of Cell Science. 116: 4867-9. PMID 14625380 DOI: 10.1242/jcs.00902 |
0.676 |
|
| 2003 |
De Amici M, Conti P, Fasoli E, Barocelli E, Ballabeni V, Bertoni S, Impicciatore M, Roth BL, Ernsberger P, De Micheli C. Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands. Farmaco (Societã Chimica Italiana : 1989). 58: 739-48. PMID 13679167 DOI: 10.1016/S0014-827X(03)00113-7 |
0.425 |
|
| 2003 |
Gray JA, Compton-Toth BA, Roth BL. Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry. 42: 10853-62. PMID 12962510 DOI: 10.1021/bi035061z |
0.624 |
|
| 2003 |
Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, Glennon RA. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. The Journal of Pharmacology and Experimental Therapeutics. 307: 138-45. PMID 12954796 DOI: 10.1124/Jpet.103.053975 |
0.392 |
|
| 2003 |
Pullagurla MR, Dukat M, Setola V, Roth B, Glennon RA. N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates. Bioorganic & Medicinal Chemistry Letters. 13: 3355-9. PMID 12951125 DOI: 10.1016/S0960-894X(03)00612-7 |
0.684 |
|
| 2003 |
Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. The Journal of Biological Chemistry. 278: 43628-35. PMID 12930822 DOI: 10.1074/Jbc.M308947200 |
0.532 |
|
| 2003 |
Peddi S, Roth BL, Glennon RA, Westkaemper RB. Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 13: 2565-8. PMID 12852967 DOI: 10.1016/S0960-894X(03)00504-3 |
0.428 |
|
| 2003 |
Shapiro DA, Renock S, Arrington E, Chiodo LA, Liu LX, Sibley DR, Roth BL, Mailman R. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1400-11. PMID 12784105 DOI: 10.1038/sj.npp.1300203 |
0.489 |
|
| 2003 |
Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL. 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Molecular Pharmacology. 63: 1223-9. PMID 12761331 DOI: 10.1124/Mol.63.6.1223 |
0.695 |
|
| 2003 |
Gray JA, Bhatnagar A, Gurevich VV, Roth BL. The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization. Molecular Pharmacology. 63: 961-72. PMID 12695524 DOI: 10.1124/Mol.63.5.961 |
0.733 |
|
| 2003 |
Xia Z, Gray JA, Compton-Toth BA, Roth BL. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. The Journal of Biological Chemistry. 278: 21901-8. PMID 12682061 DOI: 10.1074/jbc.M301905200 |
0.772 |
|
| 2003 |
Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 305: 131-42. PMID 12649361 DOI: 10.1124/Jpet.102.047092 |
0.366 |
|
| 2003 |
Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 519-26. PMID 12629531 DOI: 10.1038/Sj.Npp.1300027 |
0.485 |
|
| 2003 |
Sheffler DJ, Roth BL. Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. Trends in Pharmacological Sciences. 24: 107-9. PMID 12628350 DOI: 10.1016/S0165-6147(03)00027-0 |
0.711 |
|
| 2003 |
Faden AI, Knoblach SM, Cernak I, Fan L, Vink R, Araldi GL, Fricke ST, Roth BL, Kozikowski AP. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 342-54. PMID 12621309 DOI: 10.1097/01.Wcb.0000046143.31247.Fd |
0.302 |
|
| 2003 |
Roth BL, Sheffler D, Potkin SG. Atypical antipsychotic drug actions: Unitary or multiple mechanisms for 'atypicality'? Clinical Neuroscience Research. 3: 108-117. DOI: 10.1016/S1566-2772(03)00021-5 |
0.72 |
|
| 2003 |
Roth B, Meltzer H, Kroeze W, Evans J, Lopez E. Screening the ‘receptorome’ to discover novel proximal molecular targets of atypical antipsychotic drug actions Schizophrenia Research. 60: 314-315. DOI: 10.1016/S0920-9964(03)80261-X |
0.309 |
|
| 2002 |
Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences of the United States of America. 99: 11934-9. PMID 12192085 DOI: 10.1073/Pnas.182234399 |
0.43 |
|
| 2002 |
Gray JA, Roth BL. Cell biology. A last GASP for GPCRs? Science (New York, N.Y.). 297: 529-31. PMID 12142517 DOI: 10.1126/science.1075453 |
0.543 |
|
| 2002 |
Cornea-Hébert V, Watkins KC, Roth BL, Kroeze WK, Gaudreau P, Leclerc N, Descarries L. Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat. Neuroscience. 113: 23-35. PMID 12123681 DOI: 10.1016/S0306-4522(02)00146-X |
0.431 |
|
| 2002 |
Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J, Popadak B, Ernsberger P, Roth BL. In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. Psychopharmacology. 162: 193-202. PMID 12110997 DOI: 10.1007/S00213-002-1073-7 |
0.472 |
|
| 2002 |
Kroeze WK, Kristiansen K, Roth BL. Molecular biology of serotonin receptors structure and function at the molecular level. Current Topics in Medicinal Chemistry. 2: 507-28. PMID 12052191 |
0.371 |
|
| 2002 |
Nocjar C, Roth BL, Pehek EA. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. 111: 163-76. PMID 11955720 DOI: 10.1016/S0306-4522(01)00593-0 |
0.423 |
|
| 2002 |
Runyon SP, Peddi S, Savage JE, Roth BL, Glennon RA, Westkaemper RB. Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Journal of Medicinal Chemistry. 45: 1656-64. PMID 11931619 DOI: 10.1021/Jm010354G |
0.43 |
|
| 2002 |
Shapiro DA, Kristiansen K, Weiner DM, Kroeze WK, Roth BL. Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. The Journal of Biological Chemistry. 277: 11441-9. PMID 11801601 DOI: 10.1074/jbc.M111675200 |
0.49 |
|
| 2001 |
Roth BL, Shapiro DA. Insights into the structure and function of 5-HT(2) family serotonin receptors reveal novel strategies for therapeutic target development. Expert Opinion On Therapeutic Targets. 5: 685-695. PMID 12540278 DOI: 10.1517/14728222.5.6.685 |
0.47 |
|
| 2001 |
Gray JA, Roth BL. Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Research Bulletin. 56: 441-51. PMID 11750789 DOI: 10.1016/S0361-9230(01)00623-2 |
0.609 |
|
| 2001 |
Martín-Ruiz R, Puig MV, Celada P, Shapiro DA, Roth BL, Mengod G, Artigas F. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9856-66. PMID 11739593 DOI: 10.1523/Jneurosci.21-24-09856.2001 |
0.419 |
|
| 2001 |
Gray JA, Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, Roth BL. Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Molecular Pharmacology. 60: 1020-30. PMID 11641430 DOI: 10.1124/Mol.60.5.1020 |
0.809 |
|
| 2001 |
Rauser L, Savage JE, Meltzer HY, Roth BL. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. The Journal of Pharmacology and Experimental Therapeutics. 299: 83-9. PMID 11561066 |
0.343 |
|
| 2001 |
Roth BL, Ernsberger P, Steinberg SA, Rao S, Rauser L, Savage J, Hufeisen S, Berridge MS, Muzic RF. The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology. 157: 111-4. PMID 11512051 DOI: 10.1007/S002130100844 |
0.429 |
|
| 2001 |
Huang Y, Kegeles LS, Bae S, Hwang D, Roth BL, Savage JE, Laruelle M. Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. Bioorganic & Medicinal Chemistry Letters. 11: 1375-7. PMID 11378358 DOI: 10.1016/S0960-894X(01)00241-4 |
0.332 |
|
| 2001 |
Runyon SP, Savage JE, Taroua M, Roth BL, Glennon RA, Westkaemper RB. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorganic & Medicinal Chemistry Letters. 11: 655-8. PMID 11266163 DOI: 10.1016/S0960-894X(01)00023-3 |
0.461 |
|
| 2001 |
Westkaemper RB, Runyon SP, Savage JE, Roth BL, Glennon RA. Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor. Bioorganic & Medicinal Chemistry Letters. 11: 563-6. PMID 11229772 DOI: 10.1016/S0960-894X(01)00010-5 |
0.44 |
|
| 2001 |
Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Molecular Pharmacology. 59: 427-33. PMID 11179435 DOI: 10.1124/Mol.59.3.427 |
0.666 |
|
| 2001 |
Bubser M, Backstrom JR, Sanders-Bush E, Roth BL, Deutch AY. Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Synapse (New York, N.Y.). 39: 297-304. PMID 11169779 DOI: 10.1002/1098-2396(20010315)39:4<297::Aid-Syn1012>3.0.Co;2-Q |
0.427 |
|
| 2001 |
Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. The Journal of Biological Chemistry. 276: 8269-77. PMID 11069907 DOI: 10.1074/Jbc.M006968200 |
0.733 |
|
| 2000 |
Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 102: 2836-41. PMID 11104741 DOI: 10.1161/01.Cir.102.23.2836 |
0.453 |
|
| 2000 |
Tsai Y, Dukat M, Slassi A, MacLean N, Demchyshyn L, Savage JE, Roth BL, Hufesein S, Lee M, Glennon RA. N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. Bioorganic & Medicinal Chemistry Letters. 10: 2295-9. PMID 11055342 DOI: 10.1016/S0960-894X(00)00453-4 |
0.404 |
|
| 2000 |
Shapiro DA, Kristiansen K, Kroeze WK, Roth BL. Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. Molecular Pharmacology. 58: 877-86. PMID 11040033 DOI: 10.1124/Mol.58.5.877 |
0.45 |
|
| 2000 |
Kristiansen K, Kroeze WK, Willins DL, Gelber EI, Savage JE, Glennon RA, Roth BL. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism. The Journal of Pharmacology and Experimental Therapeutics. 293: 735-46. PMID 10869371 |
0.385 |
|
| 2000 |
Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. Journal of Medicinal Chemistry. 43: 1011-8. PMID 10715164 DOI: 10.1021/Jm990550B |
0.429 |
|
| 2000 |
Egan C, Grinde E, Dupre A, Roth BL, Hake M, Teitler M, Herrick-Davis K. Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. Synapse (New York, N.Y.). 35: 144-50. PMID 10611640 DOI: 10.1002/(Sici)1098-2396(200002)35:2<144::Aid-Syn7>3.0.Co;2-K |
0.421 |
|
| 2000 |
Roth BL, Lopez E, Patel S, Kroeze WK. The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches? The Neuroscientist. 6: 252-262. DOI: 10.1177/107385840000600408 |
0.414 |
|
| 2000 |
Roth BL, Hyde EG. Pharmacology of 5-HT2 Receptors Handbook of Experimental Pharmacology. 129: 367-394. DOI: 10.1007/978-3-642-60921-3_14 |
0.479 |
|
| 1999 |
Tan PZ, Baldwin RM, Van Dyck CH, Al-Tikriti M, Roth B, Khan N, Charney DS, Innis RB. Characterization of radioactive metabolites of 5-HT2A receptor PET ligand [18F]altanserin in human and rodent. Nuclear Medicine and Biology. 26: 601-8. PMID 10587097 DOI: 10.1016/S0969-8051(99)00022-0 |
0.386 |
|
| 1999 |
Westkaemper RB, Runyon SP, Bondarev ML, Savage JE, Roth BL, Glennon RA. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist. European Journal of Pharmacology. 380: R5-7. PMID 10513561 DOI: 10.1016/S0014-2999(99)00525-7 |
0.476 |
|
| 1999 |
Roth BL, Willins DL. What's all the RAVE about receptor internalization? Neuron. 23: 629-31. PMID 10482227 DOI: 10.1016/S0896-6273(02)23443-1 |
0.399 |
|
| 1999 |
Willins DL, Berry SA, Alsayegh L, Backstrom JR, Sanders-Bush E, Friedman L, Roth BL. Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo. Neuroscience. 91: 599-606. PMID 10366017 DOI: 10.1016/S0306-4522(98)00653-8 |
0.426 |
|
| 1999 |
Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic J, Roth BL. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. Journal of Neurochemistry. 72: 2206-14. PMID 10217304 DOI: 10.1046/J.1471-4159.1999.0722206.X |
0.6 |
|
| 1999 |
Roth BL, Willins DL, Kristiansen K, Kroeze WK. Activation is Hallucinogenic and Antagonism is Therapeutic: Role of 5-HT2A Receptors in Atypical Antipsychotic Drug Actions The Neuroscientist. 5: 254-262. DOI: 10.1177/107385849900500414 |
0.486 |
|
| 1999 |
Westkaemper RB, Hyde EG, Choudhary MS, Khan N, Gelbar EI, Glennon RA, Roth BL. Engineering a region of bulk tolerance in the 5-ht(2a) receptor European Journal of Medicinal Chemistry. 34: 441-447. DOI: 10.1016/S0223-5234(99)80094-4 |
0.442 |
|
| 1998 |
Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K. Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Critical Reviews in Neurobiology. 12: 319-38. PMID 10348614 DOI: 10.1615/Critrevneurobiol.V12.I4.30 |
0.476 |
|
| 1998 |
Willins DL, Alsayegh L, Berry SA, Backstrom JR, Sanders-Bush E, Friedman L, Khan N, Roth BL. Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo. Annals of the New York Academy of Sciences. 861: 121-7. PMID 9928248 DOI: 10.1111/J.1749-6632.1998.Tb10182.X |
0.455 |
|
| 1998 |
Kroeze WK, Roth BL. The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis. Biological Psychiatry. 44: 1128-42. PMID 9836016 DOI: 10.1016/S0006-3223(98)00132-2 |
0.502 |
|
| 1998 |
Roth BL, Willins DL, Kristiansen K, Kroeze WK. 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacology & Therapeutics. 79: 231-57. PMID 9776378 DOI: 10.1016/S0163-7258(98)00019-9 |
0.476 |
|
| 1998 |
Roth BL, Willins DL, Kroeze WK. G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse. Drug and Alcohol Dependence. 51: 73-85. PMID 9716931 DOI: 10.1016/S0376-8716(98)00067-2 |
0.399 |
|
| 1998 |
Roth BL, Meltzer HY, Khan N. Binding of typical and atypical antipsychotic drugs to multiple neurotransmitter receptors. Advances in Pharmacology (San Diego, Calif.). 42: 482-5. PMID 9327944 DOI: 10.1016/S1054-3589(08)60793-0 |
0.455 |
|
| 1998 |
Berry SA, Willins DL, Alsayegh L, Roth BL. 131. Clozapine-induced internalization of the 5-HT2A receptor in vitro Biological Psychiatry. 43. DOI: 10.1016/S0006-3223(98)90579-0 |
0.452 |
|
| 1997 |
Roth BL, Shoham M, Choudhary MS, Khan N. Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors. Molecular Pharmacology. 52: 259-66. PMID 9271348 DOI: 10.1124/Mol.52.2.259 |
0.412 |
|
| 1997 |
Willins DL, Deutch AY, Roth BL. Serotonin 5-HT(2A) receptors are expressed on pyramidal cells and interneurons in the rat cortex Synapse. 27: 79-82. PMID 9268067 DOI: 10.1002/(Sici)1098-2396(199709)27:1<79::Aid-Syn8>3.0.Co;2-A |
0.364 |
|
| 1997 |
Roth BL, Choudhary MS, Khan N, Uluer AZ. High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine2A receptors: evidence in favor of a modified ternary complex model. The Journal of Pharmacology and Experimental Therapeutics. 280: 576-83. PMID 9023266 |
0.346 |
|
| 1997 |
Berry SA, Alsayegh L, Roth BL. Regulation of the internalization of the 5HT2A receptor in vitro Schizophrenia Research. 24: 90. DOI: 10.1016/S0920-9964(97)82244-X |
0.441 |
|
| 1996 |
Pälvimäki EP, Roth BL, Majasuo H, Laakso A, Kuoppamäki M, Syvälahti E, Hietala J. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor Psychopharmacology. 126: 234-240. PMID 8876023 DOI: 10.1007/Bf02246453 |
0.477 |
|
| 1996 |
Berry SA, Shah MC, Khan N, Roth BL. Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro. Molecular Pharmacology. 50: 306-13. PMID 8700138 |
0.359 |
|
| 1996 |
Kohen R, Metcalf MA, Khan N, Druck T, Huebner K, Lachowicz JE, Meltzer HY, Sibley DR, Roth BL, Hamblin MW. Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. Journal of Neurochemistry. 66: 47-56. PMID 8522988 DOI: 10.1046/J.1471-4159.1996.66010047.X |
0.43 |
|
| 1996 |
Roth B, Hamblin M, Sibley D, Meltzer H. Binding of atypical antipsychotic drugs to novel neurotransmitter receptors Schizophrenia Research. 18: 142. DOI: 10.1016/0920-9964(96)85467-3 |
0.444 |
|
| 1996 |
Berry SA, Khan N, Roth BL. Agonist-induced internalization of the 5HT2A receptor in vitro Biological Psychiatry. 39: 531-532. DOI: 10.1016/0006-3223(96)84059-5 |
0.457 |
|
| 1996 |
Fatemi SH, Meltzer HY, Roth BL. Atypical Antipsychotic Drugs: Clinical and Preclinical Studies Handbook of Experimental Pharmacology. 120: 77-115. DOI: 10.1007/978-3-642-61007-3_4 |
0.371 |
|
| 1995 |
Roth BL, Tandra S, Burgess LH, Sibley DR, Meltzer HY. D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. Psychopharmacology. 120: 365-8. PMID 8524985 DOI: 10.1007/Bf02311185 |
0.386 |
|
| 1994 |
Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist. Journal of Medicinal Chemistry. 37: 4346-51. PMID 7996545 DOI: 10.1021/Jm00051A011 |
0.349 |
|
| 1994 |
Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma FJ, Shen Y, Meltzer HY, Sibley DR. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. The Journal of Pharmacology and Experimental Therapeutics. 268: 1403-10. PMID 7908055 |
0.329 |
|
| 1994 |
Nash JF, Roth BL, Brodkin JD, Nichols DE, Gudelsky GA. Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphatidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors. Neuroscience Letters. 177: 111-5. PMID 7824160 DOI: 10.1016/0304-3940(94)90057-4 |
0.436 |
|
| 1994 |
Roth BL. Multiple serotonin receptors: clinical and experimental aspects. Annals of Clinical Psychiatry. 6: 67-78. PMID 7804391 DOI: 10.3109/10401239409148985 |
0.449 |
|
| 1993 |
Choudhary MS, Craigo S, Roth BL. A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors. Molecular Pharmacology. 43: 755-61. PMID 8388989 |
0.329 |
|
| 1993 |
Ciaranello RD, Aimi J, Dean R, Desai R, Garlow S, Heller MR, Morilak D, Roth BL. Developmental regulation of 5-HT2 and 5-HT1c receptor gene expression in rat brain. Psychopharmacology Series. 10: 26-37. PMID 8361980 DOI: 10.1007/978-3-642-78010-3_4 |
0.631 |
|
| 1993 |
Garlow SJ, Morilak DA, Dean RR, Roth BL, Ciaranello RD. Production and characterization of a specific 5-HT2 receptor antibody. Brain Research. 615: 113-20. PMID 7689908 DOI: 10.1016/0006-8993(93)91121-8 |
0.598 |
|
| 1993 |
Roth BL, Craigo S, Choudhary S. Clozapine, risperidone and spiperone prefer distinct domains of the 5-HT2 serotonin receptor for high affinity binding Schizophrenia Research. 9: 227. DOI: 10.1016/0920-9964(93)90498-8 |
0.427 |
|
| 1992 |
Choudhary MS, Craigo S, Roth BL. Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors. Molecular Pharmacology. 42: 627-33. PMID 1435740 |
0.374 |
|
| 1992 |
Roth BL, Ciaranello RD, Meltzer HY. Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. The Journal of Pharmacology and Experimental Therapeutics. 260: 1361-5. PMID 1347569 |
0.639 |
|
| 1991 |
Roth BL, Hamblin MW, Ciaranello RD. Developmental regulation of 5-HT2 and 5-HT1c mRNA and receptor levels. Brain Research. Developmental Brain Research. 58: 51-8. PMID 2015654 DOI: 10.1016/0165-3806(91)90236-C |
0.634 |
|
| 1991 |
Roth BL, Ciaranello RD. Chronic mianserin treatment decreases 5-HT2 receptor binding without altering 5-HT2 receptor mRNA levels. European Journal of Pharmacology. 207: 169-72. PMID 1879460 DOI: 10.1016/0922-4106(91)90093-W |
0.604 |
|
| 1990 |
Seggel MR, Yousif MY, Lyon RA, Titeler M, Roth BL, Suba EA, Glennon RA. A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors. Journal of Medicinal Chemistry. 33: 1032-6. PMID 2308135 DOI: 10.1021/Jm00165A023 |
0.444 |
|
| 1990 |
Roth BL, Hamblin M, Ciaranello RD. Regulation of 5-HT2 and 5-HT1C serotonin receptor levels. Methodology and mechanisms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 3: 427-33. PMID 2078277 |
0.655 |
|
| 1989 |
Roth BL, Mehegan JP, Jacobowitz DM, Robey F, Iadarola MJ. Rat brain protein kinase C: purification, antibody production, and quantification in discrete regions of hippocampus. Journal of Neurochemistry. 52: 215-21. PMID 2908889 DOI: 10.1111/J.1471-4159.1989.Tb10919.X |
0.417 |
|
| 1989 |
Roth BL, Iadarola MJ, Mehegan JP, Jacobowitz DM. Immunohistochemical distribution of beta-protein kinase C in rat hippocampus determined with an antibody against a synthetic peptide sequence. Brain Research Bulletin. 22: 893-7. PMID 2765948 DOI: 10.1016/0361-9230(89)90034-8 |
0.474 |
|
| 1989 |
McLean S, Rothman RB, Chuang DM, Rice KC, Spain JW, Coscia CJ, Roth BL. Cross-linking of [125I]beta-endorphin to mu-opioid receptors during development. Brain Research. Developmental Brain Research. 45: 283-9. PMID 2540924 DOI: 10.1016/0165-3806(89)90046-1 |
0.722 |
|
| 1989 |
Roth BL, Decker L, Herkenham M. An autoradiographic study of mianserin-induced down regulation of serotonin (5HT2 and 5HT1C) receptors Biological Psychiatry. 25: A44-A45. DOI: 10.1016/0006-3223(89)91576-X |
0.435 |
|
| 1987 |
Roth BL, Chuang DM. Multiple mechanisms of serotonergic signal transduction. Life Sciences. 41: 1051-64. PMID 2441225 DOI: 10.1016/0024-3205(87)90621-7 |
0.47 |
|
| 1986 |
Chuang DM, Dillon-Carter O, Spain JW, Laskowski MB, Roth BL, Coscia CJ. Detection and characterization of beta-adrenergic receptors and adenylate cyclase in coated vesicles isolated from bovine brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 2578-84. PMID 3018196 DOI: 10.1523/Jneurosci.06-09-02578.1986 |
0.712 |
|
| 1986 |
Nicoletti F, Meek JL, Iadarola MJ, Chuang DM, Roth BL, Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. Journal of Neurochemistry. 46: 40-6. PMID 2866236 DOI: 10.1111/J.1471-4159.1986.Tb12922.X |
0.622 |
|
| 1985 |
Nakaki T, Roth BL, Chuang DM, Costa E. 5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells. Journal of Neurochemistry. 45: 920-5. PMID 3875688 DOI: 10.1111/J.1471-4159.1985.Tb04081.X |
0.343 |
|
| 1985 |
Spain JW, Roth BL, Coscia CJ. Differential ontogeny of multiple opioid receptors (mu, delta, and kappa). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 584-8. PMID 2983043 DOI: 10.1523/Jneurosci.05-03-00584.1985 |
0.737 |
|
| 1985 |
Bennett DB, Spain JW, Laskowski MB, Roth BL, Coscia CJ. Stereospecific opiate-binding sites occur in coated vesicles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 3010-5. PMID 2865342 DOI: 10.1523/Jneurosci.05-11-03010.1985 |
0.663 |
|
| 1985 |
Legan E, Chernow B, Parrillo J, Roth BL. Activation of phosphatidylinositol turnover in rat aorta by α1-adrenergic receptor stimulation European Journal of Pharmacology. 110: 389-390. PMID 2861104 DOI: 10.1016/0014-2999(85)90571-0 |
0.336 |
|
| 1984 |
Roth BL, Nakaki T, Chuang DM, Costa E. Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacology. 23: 1223-5. PMID 6521858 DOI: 10.1016/0028-3908(84)90244-2 |
0.389 |
|
| 1984 |
Roth BL, Coscia CJ. Microsomal opiate receptors: characterization of smooth microsomal and synaptic membrane opiate receptors. Journal of Neurochemistry. 42: 1677-84. PMID 6327910 DOI: 10.1111/J.1471-4159.1984.Tb12759.X |
0.726 |
|
| 1984 |
Scheibe SD, Bennett DB, Spain JW, Roth BL, Coscia CJ. Kinetic evidence for differential agonist and antagonist binding to bovine hippocampal synaptic membrane opioid receptors. The Journal of Biological Chemistry. 259: 13298-303. PMID 6092373 |
0.725 |
|
| 1983 |
Spain JW, Bennett DB, Roth BL, Coscia CJ. Ontogeny of benzomorphan-selective (kappa) sites: a computerized analysis. Life Sciences. 33: 235-8. PMID 6141487 DOI: 10.1016/0024-3205(83)90486-1 |
0.682 |
|
| 1982 |
Roth BL, Laskowski MB, Coscia CJ. Microsomal opiate receptors differ from synaptic membrane receptors in proteolytic sensitivity. Brain Research. 250: 101-9. PMID 6291719 DOI: 10.1016/0006-8993(82)90956-8 |
0.706 |
|
| 1982 |
Pryhuber KG, Roth BL, Coscia CJ. Demonstration of a slowly dissociating form of bovine hippocampal synaptic membrane opiate receptors. European Journal of Pharmacology. 83: 47-53. PMID 6290246 DOI: 10.1016/0014-2999(82)90284-9 |
0.731 |
|
| 1982 |
Wohltmann M, Roth BL, Coscia CJ. Differential postnatal development of mu and delta opiate receptors. Brain Research. 255: 679-84. PMID 6280810 DOI: 10.1016/0165-3806(82)90066-9 |
0.74 |
|
| 1981 |
Roth BL, Laskowski MB, Coscia CJ. Evidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain. The Journal of Biological Chemistry. 256: 10017-23. PMID 6268622 |
0.724 |
|
| 1981 |
Galloway MP, Roth BL, Coscia CJ. The effects of tetrahydroisoquinolinecarboxylic acids in tyrosine 3-monooxygenase. Archives of Biochemistry and Biophysics. 209: 620-7. PMID 6117253 DOI: 10.1016/0003-9861(81)90321-0 |
0.744 |
|
| 1980 |
Roth BL, Galloway MP, Coscia CJ. The effects of morphine on catecholamine metabolism during postnatal development. Brain Research. 197: 561-4. PMID 7407575 DOI: 10.1016/0006-8993(80)91147-6 |
0.738 |
|
| 1980 |
Coscia CJ, Burke WJ, Galloway MP, Kosloff AH, Lasala JM, McFarlane J, Mitchell JS, O'Toole MM, Roth BL. Effects of norlaudanosolinecarboxylic acids on enzymes of catecholamine metabolism. The Journal of Pharmacology and Experimental Therapeutics. 212: 91-6. PMID 6101345 |
0.744 |
|
| Show low-probability matches. |