Bryan L. Roth - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Psychopharmacology, 5-HT2A receptors, hallucinogens
Website:
http://pdsp.med.unc.edu/

380 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J. D2 Dopamine Receptor G protein-biased Partial Agonists Based on Cariprazine. Journal of Medicinal Chemistry. PMID 30964661 DOI: 10.1021/acs.jmedchem.9b00508  0.48
2019 Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs NM, McCorvy J, Caron MG, Roth BL, Jin J. Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. Journal of Medicinal Chemistry. PMID 30875219 DOI: 10.1021/acs.jmedchem.9b00351  0.48
2019 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, et al. Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 30842648 DOI: 10.1038/s41589-019-0242-5  0.48
2019 Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. Ultra-large library docking for discovering new chemotypes. Nature. PMID 30728502 DOI: 10.1038/s41586-019-0917-9  0.36
2018 Thompson KJ, Khajehali E, Bradley SJ, Navarrete JS, Huang XP, Slocum S, Jin J, Liu J, Xiong Y, Olsen RHJ, Diberto JF, Boyt KM, Pina MM, Pati D, Molloy C, ... ... Roth BL, et al. DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs and . Acs Pharmacology & Translational Science. 1: 61-72. PMID 30868140 DOI: 10.1021/acsptsci.8b00012  0.64
2018 Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in kappa opioid agonist binding revealed through PET imaging. Acs Chemical Neuroscience. PMID 30212182 DOI: 10.1021/acschemneuro.8b00293  0.36
2018 Che T, Roth BL. Phosphoproteomics illuminates opioid actions. Biochemistry. PMID 30179451 DOI: 10.1021/acs.biochem.8b00809  0.36
2018 McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL. Structural determinants of 5-HT receptor activation and biased agonism. Nature Structural & Molecular Biology. PMID 30127358 DOI: 10.1038/s41594-018-0116-7  0.48
2018 Weiss DR, Karpiak J, Huang XP, Sassano MF, Lyu J, Roth BL, Shoichet BK. Selectivity Challenges in Docking Screens for GPCR Targets and Anti-Targets. Journal of Medicinal Chemistry. PMID 29990431 DOI: 10.1021/acs.jmedchem.8b00718  0.48
2018 Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, et al. High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. Chemical Science. 9: 3192-3199. PMID 29732102 DOI: 10.1039/c7sc04698g  0.48
2018 Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. Correction: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. Plos One. 13: e0194984. PMID 29566092 DOI: 10.1371/journal.pone.0194984  1
2018 Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL. Structure of the Ddopamine receptor bound to the atypical antipsychotic drug risperidone. Nature. PMID 29466326 DOI: 10.1038/nature25758  0.36
2018 Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, ... ... Roth BL, et al. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell. PMID 29398112 DOI: 10.1016/j.cell.2018.01.001  0.48
2018 Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, ... ... Roth BL, et al. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell. PMID 29307491 DOI: 10.1016/j.cell.2017.12.011  0.64
2017 McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL. Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nature Chemical Biology. PMID 29227473 DOI: 10.1038/nchembio.2527  0.48
2017 Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS. The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nature Communications. 8: 1910. PMID 29208933 DOI: 10.1038/s41467-017-02084-0  0.48
2017 Huang XP, Che T, Mangano TJ, Le Rouzic V, Pan YX, Cameron MD, Baumann MH, Pasternak GW, Roth BL. Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo. Jci Insight. 2. PMID 29202454 DOI: 10.1172/jci.insight.97222  0.48
2017 Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science (New York, N.Y.). 358: 381-386. PMID 29051383 DOI: 10.1126/science.aan5468  0.48
2017 Roth BL, Irwin JJ, Shoichet BK. Discovery of new GPCR ligands to illuminate new biology. Nature Chemical Biology. 13: 1143-1151. PMID 29045379 DOI: 10.1038/nchembio.2490  0.36
2017 Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, et al. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29042451 DOI: 10.1096/fj.201700555R  0.64
2017 Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX, Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. PMID 28807672 DOI: 10.1016/j.neuropharm.2017.08.016  0.48
2017 Axen SD, Huang XP, Cáceres EL, Gendelev L, Roth BL, Keiser MJ. A simple representation of three-dimensional molecular structure. Journal of Medicinal Chemistry. PMID 28731335 DOI: 10.1021/acs.jmedchem.7b00696  0.48
2017 Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry. PMID 28657744 DOI: 10.1021/acs.jmedchem.7b00584  0.48
2017 Zheng Z, Huang XP, Mangano TJ, Zou R, Chen X, Zaidi S, Roth BL, Stevens RC, Katritch V. Structure based discovery of new antagonist and biased agonist chemotypes for the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 28339199 DOI: 10.1021/acs.jmedchem.7b00109  0.48
2017 Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC. 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28294132 DOI: 10.1038/npp.2017.52  0.64
2017 Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nature Chemical Biology. PMID 28288109 DOI: 10.1038/nchembio.2334  0.52
2017 Le Gonidec S, Chaves-Almagro C, Bai Y, Kang HJ, Smith A, Wanecq E, Huang XP, Prats H, Knibiehler B, Roth BL, Barak LS, Caron MG, Valet P, Audigier Y, Masri B. Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28242772 DOI: 10.1096/fj.201601074R  0.48
2017 Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 168: 377-389.e12. PMID 28129538 DOI: 10.1016/j.cell.2016.12.033  0.48
2016 Kim Y, Lee HM, Xiong Y, Sciaky N, Hulbert SW, Cao X, Everitt JI, Jin J, Roth BL, Jiang YH. Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. Nature Medicine. PMID 28024084 DOI: 10.1038/nm.4257  0.96
2016 Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911814 DOI: 10.1073/pnas.1614347113  0.48
2016 McCorvy JD, Olsen RH, Roth BL. Psilocybin for depression and anxiety associated with life-threatening illnesses. Journal of Psychopharmacology (Oxford, England). 30: 1209-1210. PMID 27909171 DOI: 10.1177/0269881116675771  0.48
2016 Chen X, McCorvy JD, Fischer MG, Butler KV, Shen Y, Roth BL, Jin J. Discovery of G Protein-biased D2 Dopamine Receptor Partial Agonists. Journal of Medicinal Chemistry. PMID 27805392 DOI: 10.1021/acs.jmedchem.6b01208  0.48
2016 Sato S, Huang XP, Kroeze W, Roth BL. Discovery and characterization of novel GPR39 agonists allosterically modulated by zinc. Molecular Pharmacology. PMID 27754899 DOI: 10.1124/mol.116.106112  0.48
2016 Cheng J, McCorvy JD, Giguère PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. Journal of Medicinal Chemistry. PMID 27726356 DOI: 10.1021/acs.jmedchem.6b01194  0.6
2016 Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, ... ... Roth BL, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 1-6. PMID 27533032 DOI: 10.1038/nature19112  0.48
2016 Etukala JR, Zhu XY, Eyunni SV, Onyameh EK, Ofori E, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. Bioorganic & Medicinal Chemistry. PMID 27364609 DOI: 10.1016/j.bmc.2016.06.011  0.64
2016 Ofori E, Zhu XY, Etukala JR, Peprah K, Jordan KR, Adkins AA, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. Bioorganic & Medicinal Chemistry. PMID 27312422 DOI: 10.1016/j.bmc.2016.05.053  0.64
2016 Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, ... ... Roth BL, et al. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247388 DOI: 10.1073/pnas.1602070113  0.88
2016 Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JJ, Caldarone BJ, Roth BL, Kokel D, Peterson RT. σ1 receptor ligands control a switch between passive and active threat responses. Nature Chemical Biology. PMID 27239788 DOI: 10.1038/nchembio.2089  1
2016 Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, ... ... Roth BL, et al. Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nature Chemical Biology. PMID 27239787 DOI: 10.1038/nchembio.2097  1
2016 Zhu H, Aryal DK, Olsen RH, Urban DJ, Swearingen A, Forbes S, Roth BL, Hochgeschwender U. Cre dependent DREADD (designer receptors exclusively activated by designer drugs) mice. Genesis (New York, N.Y. : 2000). PMID 27194399 DOI: 10.1002/dvg.22949  1
2016 Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. Plos Pathogens. 12: e1005651. PMID 27187180 DOI: 10.1371/journal.ppat.1005651  0.48
2016 Wacker D, Roth BL. An alerting structure: human orexin receptor 1. Nature Structural & Molecular Biology. 23: 265-6. PMID 27045444 DOI: 10.1038/nsmb.3198  1
2016 Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, ... ... Roth BL, et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. Plos One. 11: e0150602. PMID 26963248 DOI: 10.1371/journal.pone.0150602  1
2016 Roth BL. DREADDs for Neuroscientists. Neuron. 89: 683-94. PMID 26889809 DOI: 10.1016/j.neuron.2016.01.040  1
2016 Bruchas MR, Roth BL. New Technologies for Elucidating Opioid Receptor Function. Trends in Pharmacological Sciences. PMID 26833118 DOI: 10.1016/j.tips.2016.01.001  1
2016 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 26807715 DOI: 10.1038/nchembio.2007  0.48
2015 Cheng J, Giguère PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. Journal of Medicinal Chemistry. PMID 26704965 DOI: 10.1021/acs.jmedchem.5b01153  1
2015 Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, ... ... Roth BL, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. PMID 26550826 DOI: 10.1038/nature15699  0.88
2015 Elkins JM, Fedele V, Szklarz M, Abdul Azeez KR, Salah E, Mikolajczyk J, Romanov S, Sepetov N, Huang XP, Roth BL, Al Haj Zen A, Fourches D, Muratov E, Tropsha A, Morris J, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nature Biotechnology. PMID 26501955 DOI: 10.1038/nbt.3374  0.68
2015 English JG, Roth BL. Chemogenetics-A Transformational and Translational Platform. Jama Neurology. 1-6. PMID 26409113 DOI: 10.1001/jamaneurol.2015.1921  1
2015 Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL. Elucidation of the Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26383016 DOI: 10.1038/npp.2015.293  1
2015 Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. Bioorganic & Medicinal Chemistry Letters. 25: 3956-60. PMID 26231155 DOI: 10.1016/j.bmcl.2015.07.031  1
2015 Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist. Tetrahedron Letters. 56: 3420-3422. PMID 26120215 DOI: 10.1016/j.tetlet.2015.01.060  0.64
2015 Roth BL, Kroeze WK. Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily. The Journal of Biological Chemistry. 290: 19471-7. PMID 26100629 DOI: 10.1074/jbc.R115.654764  1
2015 Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22: 764-75. PMID 26091169 DOI: 10.1016/j.chembiol.2015.05.012  1
2015 Salaga M, Polepally PR, Zielinska M, Marynowski M, Fabisiak A, Murawska N, Sobczak K, Sacharczuk M, Do Rego JC, Roth BL, Zjawiony JK, Fichna J. Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice. British Journal of Pharmacology. 172: 4331-41. PMID 26040667 DOI: 10.1111/bph.13212  1
2015 Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y. Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26019014 DOI: 10.1038/npp.2015.149  0.44
2015 Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, ... ... Roth BL, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 86: 936-46. PMID 25937170 DOI: 10.1016/j.neuron.2015.03.065  1
2015 Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nature Structural & Molecular Biology. 22: 362-9. PMID 25895059 DOI: 10.1038/nsmb.3014  1
2015 Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ. Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2614-22. PMID 25881115 DOI: 10.1038/npp.2015.109  1
2015 Nocjar C, Alex KD, Sonneborn A, Abbas AI, Roth BL, Pehek EA. Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex. Neuroscience. 297: 22-37. PMID 25818050 DOI: 10.1016/j.neuroscience.2015.03.050  1
2015 Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, ... ... Roth BL, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International Ed. in English). 54: 5166-70. PMID 25728001 DOI: 10.1002/anie.201412154  1
2015 Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, ... ... Roth BL, et al. Structural basis for bifunctional peptide recognition at human δ-opioid receptor. Nature Structural & Molecular Biology. 22: 265-8. PMID 25686086 DOI: 10.1038/nsmb.2965  1
2015 Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. Journal of Medicinal Chemistry. 58: 1992-2002. PMID 25633969 DOI: 10.1021/jm5019274  1
2015 McCorvy JD, Roth BL. Structure and function of serotonin G protein-coupled receptors. Pharmacology & Therapeutics. 150: 129-42. PMID 25601315 DOI: 10.1016/j.pharmthera.2015.01.009  1
2015 Chen X, Choo H, Huang XP, Yang X, Stone O, Roth BL, Jin J. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. Acs Chemical Neuroscience. 6: 476-84. PMID 25587888 DOI: 10.1021/cn500325v  1
2015 Zhu H, Roth BL. DREADD: a chemogenetic GPCR signaling platform. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25522378 DOI: 10.1093/ijnp/pyu007  1
2015 White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL. The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo. The Journal of Pharmacology and Experimental Therapeutics. 352: 98-109. PMID 25320048 DOI: 10.1124/jpet.114.216820  1
2015 Urban DJ, Roth BL. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annual Review of Pharmacology and Toxicology. 55: 399-417. PMID 25292433 DOI: 10.1146/annurev-pharmtox-010814-124803  1
2015 Matsunaga F, Gao L, Huang XP, Saven JG, Roth BL, Liu R. Molecular interactions between general anesthetics and the 5HT2B receptor. Journal of Biomolecular Structure & Dynamics. 33: 211-8. PMID 24365264 DOI: 10.1080/07391102.2013.869483  1
2015 Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP. Design and synthesis of (2-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a selective serotonin 2C agonist This Letter is dedicated to the lasting memory of Harry H. Wasserman, a connoisseur of heterocycles Tetrahedron Letters. 56: 3420-3422. DOI: 10.1016/j.tetlet.2015.01.060  1
2014 Cero C, Vostrikov VV, Verardi R, Severini C, Gopinath T, Braun PD, Sassano MF, Gurney A, Roth BL, Vulchanova L, Possenti R, Veglia G, Bartolomucci A. The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism. Structure (London, England : 1993). 22: 1744-53. PMID 25456411 DOI: 10.1016/j.str.2014.10.001  1
2014 Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK. Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor. European Journal of Medicinal Chemistry. 85: 818-29. PMID 25193297 DOI: 10.1016/j.ejmech.2014.07.077  1
2014 Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Further evaluation of the tropane analogs of haloperidol. Bioorganic & Medicinal Chemistry Letters. 24: 4294-7. PMID 25070422 DOI: 10.1016/j.bmcl.2014.07.018  1
2014 Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nature Communications. 5: 4355. PMID 25008467 DOI: 10.1038/ncomms5355  1
2014 Sternson SM, Roth BL. Chemogenetic tools to interrogate brain functions. Annual Review of Neuroscience. 37: 387-407. PMID 25002280 DOI: 10.1146/annurev-neuro-071013-014048  1
2014 Zhu H, Roth BL. Silencing synapses with DREADDs. Neuron. 82: 723-5. PMID 24853931 DOI: 10.1016/j.neuron.2014.05.002  1
2014 Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Identification of a new selective dopamine D4 receptor ligand. Bioorganic & Medicinal Chemistry. 22: 3105-14. PMID 24800940 DOI: 10.1016/j.bmc.2014.04.026  1
2014 Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. Acs Chemical Neuroscience. 5: 576-87. PMID 24793972 DOI: 10.1021/cn500082p  1
2014 Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC. Allosteric sodium in class A GPCR signaling. Trends in Biochemical Sciences. 39: 233-44. PMID 24767681 DOI: 10.1016/j.tibs.2014.03.002  1
2014 Giguere PM, Kroeze WK, Roth BL. Tuning up the right signal: chemical and genetic approaches to study GPCR functions. Current Opinion in Cell Biology. 27: 51-5. PMID 24680430 DOI: 10.1016/j.ceb.2013.11.006  1
2014 Zhu H, Pleil KE, Urban DJ, Moy SS, Kash TL, Roth BL. Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1880-92. PMID 24525710 DOI: 10.1038/npp.2014.35  1
2014 Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Research. 1554: 36-48. PMID 24472579 DOI: 10.1016/j.brainres.2014.01.036  1
2014 Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. Molecular control of δ-opioid receptor signalling. Nature. 506: 191-6. PMID 24413399 DOI: 10.1038/nature12944  1
2014 Luo M, Wang XS, Roth BL, Golbraikh A, Tropsha A. Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. Journal of Chemical Information and Modeling. 54: 634-47. PMID 24410373 DOI: 10.1021/ci400460q  1
2014 Fourches D, Sassano MF, Roth BL, Tropsha A. HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data. Bioinformatics (Oxford, England). 30: 588-9. PMID 24376084 DOI: 10.1093/bioinformatics/btt718  1
2014 Liu R, Huang XP, Yeliseev A, Xi J, Roth BL. Novel molecular targets of dezocine and their clinical implications. Anesthesiology. 120: 714-23. PMID 24263237 DOI: 10.1097/ALN.0000000000000076  1
2014 Lee HM, Giguere PM, Roth BL. DREADDs: novel tools for drug discovery and development. Drug Discovery Today. 19: 469-73. PMID 24184433 DOI: 10.1016/j.drudis.2013.10.018  1
2014 White KL, Scopton AP, Rives ML, Bikbulatov RV, Polepally PR, Brown PJ, Kenakin T, Javitch JA, Zjawiony JK, Roth BL. Identification of novel functionally selective κ-opioid receptor scaffolds. Molecular Pharmacology. 85: 83-90. PMID 24113749 DOI: 10.1124/mol.113.089649  1
2013 Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, et al. Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Acs Medicinal Chemistry Letters. 4: 1005-1010. PMID 24454993 DOI: 10.1021/ml400312j  1
2013 Meltzer HY, Roth BL. Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs. The Journal of Clinical Investigation. 123: 4986-91. PMID 24292660 DOI: 10.1172/JCI70678  1
2013 Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. Plos Biology. 11: e1001712. PMID 24260022 DOI: 10.1371/journal.pbio.1001712  1
2013 Carroll FI, Gichinga MG, Williams JD, Vardy E, Roth BL, Mascarella SW, Thomas JB, Navarro HA. 4β-Methyl-5-(3-hydroxyphenyl)morphan opioid agonist and partial agonist derived from a 4β-methyl-5-(3-hydroxyphenyl)morphan pure antagonist. Journal of Medicinal Chemistry. 56: 8826-33. PMID 24144404 DOI: 10.1021/jm401250s  1
2013 Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83. PMID 24121503 DOI: 10.1074/jbc.M113.515668  1
2013 Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of Medicinal Chemistry. 56: 8931-42. PMID 24102134 DOI: 10.1021/jm401480r  1
2013 Agulhon C, Boyt KM, Xie AX, Friocourt F, Roth BL, McCarthy KD. Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo. The Journal of Physiology. 591: 5599-609. PMID 24042499 DOI: 10.1113/jphysiol.2013.261289  1
2013 Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists. Chemmedchem. 8: 1855-64. PMID 24039134 DOI: 10.1002/cmdc.201300240  1
2013 Becnel J, Johnson O, Majeed ZR, Tran V, Yu B, Roth BL, Cooper RL, Kerut EK, Nichols CD. DREADDs in Drosophila: a pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly. Cell Reports. 4: 1049-59. PMID 24012754 DOI: 10.1016/j.celrep.2013.08.003  1
2013 Munro TA, Huang XP, Inglese C, Perrone MG, Van't Veer A, Carroll FI, Béguin C, Carlezon WA, Colabufo NA, Cohen BM, Roth BL. Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters. Plos One. 8: e70701. PMID 23976952 DOI: 10.1371/journal.pone.0070701  1
2013 Ferguson SM, Phillips PE, Roth BL, Wess J, Neumaier JF. Direct-pathway striatal neurons regulate the retention of decision-making strategies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11668-76. PMID 23843534 DOI: 10.1523/JNEUROSCI.4783-12.2013  1
2013 Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 497: 338-43. PMID 23636324 DOI: 10.1038/nature12167  1
2013 Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, ... Roth BL, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34. PMID 23614352 DOI: 10.1021/cb400133j  1
2013 Arunotayanun W, Dalley JW, Huang XP, Setola V, Treble R, Iversen L, Roth BL, Gibbons S. An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorganic & Medicinal Chemistry Letters. 23: 3411-5. PMID 23602445 DOI: 10.1016/j.bmcl.2013.03.066  1
2013 Polepally PR, White K, Vardy E, Roth BL, Ferreira D, Zjawiony JK. Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands. Bioorganic & Medicinal Chemistry Letters. 23: 2860-2. PMID 23587424 DOI: 10.1016/j.bmcl.2013.03.111  1
2013 Roth BL. Impossible or merely difficult? Two grand challenges from a biologist's perspective. Acs Medicinal Chemistry Letters. 4: 316-318. PMID 23544175 DOI: 10.1021/ml4000386  1
2013 Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H. Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorganic & Medicinal Chemistry. 21: 2568-76. PMID 23541835 DOI: 10.1016/j.bmc.2013.02.038  1
2013 Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. Plos One. 8: e59334. PMID 23527166 DOI: 10.1371/journal.pone.0059334  1
2013 Parnaudeau S, O'Neill PK, Bolkan SS, Ward RD, Abbas AI, Roth BL, Balsam PD, Gordon JA, Kellendonk C. Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron. 77: 1151-62. PMID 23522049 DOI: 10.1016/j.neuron.2013.01.038  1
2013 Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Structural features for functional selectivity at serotonin receptors. Science (New York, N.Y.). 340: 615-9. PMID 23519215 DOI: 10.1126/science.1232808  1
2013 Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, ... ... Roth BL, et al. Structural basis for molecular recognition at serotonin receptors. Science (New York, N.Y.). 340: 610-4. PMID 23519210 DOI: 10.1126/science.1232807  1
2013 Weiss DR, Ahn S, Sassano MF, Kleist A, Zhu X, Strachan R, Roth BL, Lefkowitz RJ, Shoichet BK. Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. Acs Chemical Biology. 8: 1018-26. PMID 23485065 DOI: 10.1021/cb400103f  1
2013 McElligott ZA, Fox ME, Walsh PL, Urban DJ, Ferrel MS, Roth BL, Wightman RM. Noradrenergic synaptic function in the bed nucleus of the stria terminalis varies in animal models of anxiety and addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1665-73. PMID 23467277 DOI: 10.1038/npp.2013.63  1
2013 Sassano MF, Doak AK, Roth BL, Shoichet BK. Colloidal aggregation causes inhibition of G protein-coupled receptors. Journal of Medicinal Chemistry. 56: 2406-14. PMID 23437772 DOI: 10.1021/jm301749y  1
2013 Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nature Chemical Biology. 9: 257-63. PMID 23396078 DOI: 10.1038/nchembio.1183  1
2013 Vardy E, Roth BL. Conformational ensembles in GPCR activation. Cell. 152: 385-6. PMID 23374334 DOI: 10.1016/j.cell.2013.01.025  1
2013 Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, ... ... Roth BL, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 854-62. PMID 23303063 DOI: 10.1038/npp.2012.251  1
2013 Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI. Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 299-305. PMID 23297076 DOI: 10.2967/jnumed.112.108688  1
2013 Lin H, Sassano MF, Roth BL, Shoichet BK. A pharmacological organization of G protein-coupled receptors. Nature Methods. 10: 140-6. PMID 23291723 DOI: 10.1038/nmeth.2324  1
2013 Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C. Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. The American Journal of Pathology. 182: 776-85. PMID 23291213 DOI: 10.1016/j.ajpath.2012.11.021  1
2013 Iversen L, Gibbons S, Treble R, Setola V, Huang XP, Roth BL. Neurochemical profiles of some novel psychoactive substances. European Journal of Pharmacology. 700: 147-51. PMID 23261499 DOI: 10.1016/j.ejphar.2012.12.006  1
2013 Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorganic & Medicinal Chemistry. 21: 93-101. PMID 23218469 DOI: 10.1016/j.bmc.2012.10.057  1
2013 Farrell MS, Roth BL. Pharmacosynthetics: Reimagining the pharmacogenetic approach. Brain Research. 1511: 6-20. PMID 23063887 DOI: 10.1016/j.brainres.2012.09.043  1
2013 Wu H, Li J, Fronczek FR, Ferreira D, Burandt CL, Setola V, Roth BL, Zjawiony JK. Labdane diterpenoids from Leonotis leonurus. Phytochemistry. 91: 229-35. PMID 22445074 DOI: 10.1016/j.phytochem.2012.02.021  1
2013 Sassano MF, Allen JA, Jin J, Setola V, Wetsel WC, Caron MG, Roth BL. D2 Functionally Selective Ligands: Novel Therapeutics? Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 105. DOI: 10.1016/B978-0-12-800044-1.00091-X  1
2013 Roth BL, Sassano MF, Kroeze WK. Simultaneous, Massively Parallel and Genome-Wide Interrogation of GPCR b-arrestin-ergic Signaling: Implications for GPCR Drug Discovery and Catecholamine Biology Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 101-102. DOI: 10.1016/B978-0-12-800044-1.00088-X  1
2012 Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, ... ... Roth BL, et al. Automated design of ligands to polypharmacological profiles. Nature. 492: 215-20. PMID 23235874 DOI: 10.1038/nature11691  1
2012 Roth BL, Marshall FH. NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family. Nature. 492: 57. PMID 23222609 DOI: 10.1038/492057a  1
2012 Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE. trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. Beilstein Journal of Organic Chemistry. 8: 1705-9. PMID 23209503 DOI: 10.3762/bjoc.8.194  1
2012 White KL, Roth BL. Psychotomimetic effects of kappa opioid receptor agonists. Biological Psychiatry. 72: 797-8. PMID 23083945 DOI: 10.1016/j.biopsych.2012.08.014  1
2012 Zhu H, Urban DJ, Blashka J, McPheeters MT, Kroeze WK, Mieczkowski P, Overholser JC, Jurjus GJ, Dieter L, Mahajan GJ, Rajkowska G, Wang Z, Sullivan PF, Stockmeier CA, Roth BL. Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders. Plos One. 7: e43227. PMID 22912834 DOI: 10.1371/journal.pone.0043227  1
2012 Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC. Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels. Chemical Research in Toxicology. 25: 1975-84. PMID 22856456 DOI: 10.1021/tx300283t  1
2012 Chen X, Sassano MF, Zheng L, Setola V, Chen M, Bai X, Frye SV, Wetsel WC, Roth BL, Jin J. Structure-functional selectivity relationship studies of β-arrestin-biased dopamine Dâ‚‚ receptor agonists. Journal of Medicinal Chemistry. 55: 7141-53. PMID 22845053 DOI: 10.1021/jm300603y  1
2012 Mangin F, Dilly S, Joly B, Scuvée-Moreau J, Evans J, Setola V, Roth BL, Liégeois JF. Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. Bioorganic & Medicinal Chemistry Letters. 22: 4550-4. PMID 22738628 DOI: 10.1016/j.bmcl.2012.05.119  1
2012 Gregori-Puigjané E, Setola V, Hert J, Crews BA, Irwin JJ, Lounkine E, Marnett L, Roth BL, Shoichet BK. Identifying mechanism-of-action targets for drugs and probes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11178-83. PMID 22711801 DOI: 10.1073/pnas.1204524109  1
2012 Lin X, Huang XP, Chen G, Whaley R, Peng S, Wang Y, Zhang G, Wang SX, Wang S, Roth BL, Huang N. Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors. Journal of Medicinal Chemistry. 55: 5749-59. PMID 22694093 DOI: 10.1021/jm300338m  1
2012 Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 485: 395-9. PMID 22596163 DOI: 10.1038/nature11085  1
2012 Hajjo R, Setola V, Roth BL, Tropsha A. Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers. Journal of Medicinal Chemistry. 55: 5704-19. PMID 22537153 DOI: 10.1021/jm2011657  1
2012 Zhu XY, Etukala JR, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European Journal of Medicinal Chemistry. 53: 124-32. PMID 22520153 DOI: 10.1016/j.ejmech.2012.03.042  1
2012 Li J, Fronczek FR, Ferreira D, Burandt CL, Setola V, Roth BL, Zjawiony JK. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products. 75: 728-34. PMID 22475308 DOI: 10.1021/np3000156  1
2012 Garner AR, Rowland DC, Hwang SY, Baumgaertel K, Roth BL, Kentros C, Mayford M. Generation of a synthetic memory trace. Science (New York, N.Y.). 335: 1513-6. PMID 22442487 DOI: 10.1126/science.1214985  1
2012 Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, et al. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-32. PMID 22437504 DOI: 10.1038/nature10939  1
2012 Peprah K, Zhu XY, Eyunni SV, Etukala JR, Setola V, Roth BL, Ablordeppey SY. Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol. Bioorganic & Medicinal Chemistry. 20: 1671-8. PMID 22336245 DOI: 10.1016/j.bmc.2012.01.022  1
2012 Lee HM, Roth BL. Hallucinogen actions on human brain revealed. Proceedings of the National Academy of Sciences of the United States of America. 109: 1820-1. PMID 22308478 DOI: 10.1073/pnas.1121358109  1
2012 Peprah K, Zhu XY, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents. Bioorganic & Medicinal Chemistry. 20: 1291-7. PMID 22245230 DOI: 10.1016/j.bmc.2011.12.019  1
2012 Kim MK, Lee HS, Kim S, Cho SY, Roth BL, Chong Y, Choo H. 4-Aminoethylpiperazinyl aryl ketones with 5-HT₁A/5-HT₇ selectivity. Bioorganic & Medicinal Chemistry. 20: 1139-48. PMID 22196512 DOI: 10.1016/j.bmc.2011.11.005  1
2012 Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 481: 185-9. PMID 22190039 DOI: 10.1038/nature10726  1
2012 Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK. Chemical informatics and target identification in a zebrafish phenotypic screen. Nature Chemical Biology. 8: 144-6. PMID 22179068 DOI: 10.1038/nchembio.732  1
2012 Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 17, (6727-6732) DOI: 10.1073/pnas.1016558108) Proceedings of the National Academy of Sciences of the United States of America. 109: 15526-15527. DOI: 10.1073/pnas.1213952109  1
2012 Kroeze WK, Roth BL. Polypharmacological Drugs: "Magic Shotguns" for Psychiatric Diseases Polypharmacology in Drug Discovery. 133-148. DOI: 10.1002/9781118098141.ch7  1
2011 Allen JA, Yadav PN, Setola V, Farrell M, Roth BL. Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo. Translational Psychiatry. 1: e33. PMID 22832607 DOI: 10.1038/tp.2011.35  1
2011 Chen G, Cho SJ, Huang XP, Jensen NH, Svennebring A, Sassano MF, Roth BL, Kozikowski AP. Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity. Acs Medicinal Chemistry Letters. 2: 929-932. PMID 22778800 DOI: 10.1021/ml200206z  1
2011 Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, ... ... Roth BL, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proceedings of the National Academy of Sciences of the United States of America. 108: 18488-93. PMID 22025698 DOI: 10.1073/pnas.1104807108  1
2011 Carlsson J, Coleman RG, Setola V, Irwin JJ, Fan H, Schlessinger A, Sali A, Roth BL, Shoichet BK. Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nature Chemical Biology. 7: 769-78. PMID 21926995 DOI: 10.1038/nchembio.662  1
2011 Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, ... ... Roth BL, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature Chemical Biology. 7: 566-74. PMID 21743462 DOI: 10.1038/nchembio.599  1
2011 Yadav PN, Kroeze WK, Farrell MS, Roth BL. Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo. The Journal of Pharmacology and Experimental Therapeutics. 339: 99-105. PMID 21737536 DOI: 10.1124/jpet.111.183780  1
2011 Vardy E, Roth BL. Vision and olfaction say UNC-le to G proteins. Nature Neuroscience. 14: 805-6. PMID 21709674 DOI: 10.1038/nn.2863  1
2011 Whitby LR, Ando Y, Setola V, Vogt PK, Roth BL, Boger DL. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions. Journal of the American Chemical Society. 133: 10184-94. PMID 21609016 DOI: 10.1021/ja201878v  1
2011 Hutcheson JD, Setola V, Roth BL, Merryman WD. Serotonin receptors and heart valve disease--it was meant 2B. Pharmacology & Therapeutics. 132: 146-57. PMID 21440001 DOI: 10.1016/j.pharmthera.2011.03.008  1
2011 Rogan SC, Roth BL. Remote control of neuronal signaling. Pharmacological Reviews. 63: 291-315. PMID 21415127 DOI: 10.1124/pr.110.003020  1
2011 Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proceedings of the National Academy of Sciences of the United States of America. 108: 6727-32. PMID 21368188 DOI: 10.1073/pnas.1016558108  1
2011 Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. The Journal of Clinical Investigation. 121: 1424-8. PMID 21364278 DOI: 10.1172/JCI46229  1
2011 Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine regulation of male fertility by the skeleton. Cell. 144: 796-809. PMID 21333348 DOI: 10.1016/j.cell.2011.02.004  1
2011 Roth BL. Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation. Neuropharmacology. 61: 348-54. PMID 21288474 DOI: 10.1016/j.neuropharm.2011.01.012  1
2011 McKenna DJ, Ruiz JM, Hoye TR, Roth BL, Shoemaker AT. Receptor screening technologies in the evaluation of Amazonian ethnomedicines with potential applications to cognitive deficits. Journal of Ethnopharmacology. 134: 475-92. PMID 21232588 DOI: 10.1016/j.jep.2010.12.037  1
2011 Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF. Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nature Neuroscience. 14: 22-4. PMID 21131952 DOI: 10.1038/nn.2703  1
2011 Fichna J, Lewellyn K, Yan F, Roth BL, Zjawiony JK. Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids. Bioorganic & Medicinal Chemistry Letters. 21: 160-3. PMID 21115248 DOI: 10.1016/j.bmcl.2010.11.046  1
2011 Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, ... Roth BL, et al. The presynaptic component of the serotonergic system is required for clozapine's efficacy. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 638-51. PMID 21048700 DOI: 10.1038/npp.2010.195  1
2011 Allen JA, Roth BL. Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annual Review of Pharmacology and Toxicology. 51: 117-44. PMID 20868273 DOI: 10.1146/annurev-pharmtox-010510-100553  1
2011 Davies MA, Conley Y, Roth BL. Functional SNPs in genes encoding the 5-HT2A receptor modify the affinity and potency of several atypical antipsychotic drugs. Biological Research For Nursing. 13: 55-60. PMID 20097665 DOI: 10.1177/1099800409358760  1
2010 Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL. Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting. Assay and Drug Development Technologies. 8: 727-42. PMID 21158687 DOI: 10.1089/adt.2010.0331  1
2010 Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. Journal of Medicinal Chemistry. 53: 7573-86. PMID 20958049 DOI: 10.1021/jm100600y  1
2010 Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorganic & Medicinal Chemistry. 18: 7548-64. PMID 20888240 DOI: 10.1016/j.bmc.2010.08.049  1
2010 Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J. N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands. Acs Medicinal Chemistry Letters. 1: 189-193. PMID 20729985 DOI: 10.1021/ml100040t  1
2010 Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, et al. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8. PMID 20727364 DOI: 10.1016/j.neuropharm.2010.08.011  1
2010 Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B. Bioorganic & Medicinal Chemistry Letters. 20: 5488-90. PMID 20692833 DOI: 10.1016/j.bmcl.2010.07.074  1
2010 Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. American Journal of Physiology. Cell Physiology. 299: C654-64. PMID 20573995 DOI: 10.1152/ajpcell.00441.2009  1
2010 Kozikowski AP, Cho SJ, Jensen NH, Allen JA, Svennebring AM, Roth BL. HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia. Chemmedchem. 5: 1221-5. PMID 20533502 DOI: 10.1002/cmdc.201000186  1
2010 Dong S, Allen JA, Farrell M, Roth BL. A chemical-genetic approach for precise spatio-temporal control of cellular signaling. Molecular Biosystems. 6: 1376-80. PMID 20532295 DOI: 10.1039/c002568m  1
2010 Morabito MV, Abbas AI, Hood JL, Kesterson RA, Jacobs MM, Kump DS, Hachey DL, Roth BL, Emeson RB. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiology of Disease. 39: 169-80. PMID 20394819 DOI: 10.1016/j.nbd.2010.04.004  1
2010 Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nature Neuroscience. 13: 622-9. PMID 20383137 DOI: 10.1038/nn.2529  1
2010 Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, Roth BL, Cohen BM, Carlezon WA. Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats. Psychopharmacology. 210: 263-74. PMID 20358363 DOI: 10.1007/s00213-010-1834-7  1
2010 Dong S, Rogan SC, Roth BL. Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs. Nature Protocols. 5: 561-73. PMID 20203671 DOI: 10.1038/nprot.2009.239  1
2010 Abbas AI, Urban DJ, Jensen NH, Farrell MS, Kroeze WK, Mieczkowski P, Wang Z, Roth BL. Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method. Nucleic Acids Research. 38: e118. PMID 20185571 DOI: 10.1093/nar/gkq107  1
2010 Glennon RA, Siripurapu U, Roth BL, Kolanos R, Bondarev ML, Sikazwe D, Lee M, Dukat M. The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs. Current Topics in Medicinal Chemistry. 10: 579-95. PMID 20166945 DOI: 10.2174/156802610791111542  1
2010 Farrell M, Roth BL. Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 851-2. PMID 20145632 DOI: 10.1038/npp.2009.206  1
2010 Strachan RT, Allen JA, Sheffler DJ, Roth BL. p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling. Biochemistry. 49: 2657-71. PMID 20136148 DOI: 10.1021/bi901921k  1
2010 McGovern DL, Mosier PD, Roth BL, Westkaemper RB. CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity. Journal of Molecular Graphics & Modelling. 28: 612-25. PMID 20083418 DOI: 10.1016/j.jmgm.2009.12.008  1
2010 Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86. PMID 20074611 DOI: 10.1016/j.pnpbp.2010.01.004  1
2010 Pei Y, Dong S, Roth BL. Generation of designer receptors exclusively activated by designer drugs (DREADDs) using directed molecular evolution. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.33. PMID 20066658 DOI: 10.1002/0471142301.ns0433s50  1
2010 Shah JR, Mosier PD, Peddi S, Roth BL, Westkaemper RB. 9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites. Bioorganic & Medicinal Chemistry Letters. 20: 935-8. PMID 20045641 DOI: 10.1016/j.bmcl.2009.12.064  1
2010 Strachan RT, Sciaky N, Cronan MR, Kroeze WK, Roth BL. Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity. Molecular Pharmacology. 77: 327-38. PMID 19933401 DOI: 10.1124/mol.109.061440  1
2010 Roth BL, Rogan SC. Neuropharmacological Profiles of Antipsychotic Drugs Dopamine Handbook. DOI: 10.1093/acprof:oso/9780195373035.003.0037  1
2010 Graulich A, Ĺonard M, Ŕsimont M, Huang XP, Roth BL, Lígeois JF. Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies Australian Journal of Chemistry. 63: 56-67. DOI: 10.1071/CH09353  1
2009 Nichols CD, Roth BL. Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Frontiers in Molecular Neuroscience. 2: 16. PMID 19893765 DOI: 10.3389/neuro.02.016.2009  1
2009 Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P. Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 19575-80. PMID 19889983 DOI: 10.1073/pnas.0905884106  1
2009 Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, ... ... Roth BL, et al. Predicting new molecular targets for known drugs. Nature. 462: 175-81. PMID 19881490 DOI: 10.1038/nature08506  1
2009 Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 19197-202. PMID 19858481 DOI: 10.1073/pnas.0906593106  1
2009 Shah JR, Mosier PD, Roth BL, Kellogg GE, Westkaemper RB. Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorganic & Medicinal Chemistry. 17: 6496-504. PMID 19700330 DOI: 10.1016/j.bmc.2009.08.016  1
2009 Allen JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Molecular Pharmacology. 76: 1082-93. PMID 19696145 DOI: 10.1124/mol.109.060160  1
2009 Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annual Review of Medicine. 60: 355-66. PMID 19630576 DOI: 10.1146/annurev.med.60.042307.110802  1
2009 Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO, Roth BL. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron. 63: 27-39. PMID 19607790 DOI: 10.1016/j.neuron.2009.06.014  1
2009 Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL. Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment. Molecular Pharmacology. 76: 710-22. PMID 19570945 DOI: 10.1124/mol.109.058057  1
2009 Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry. 48: 6898-908. PMID 19555087 DOI: 10.1021/bi900605n  1
2009 Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL. PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7124-36. PMID 19494135 DOI: 10.1523/JNEUROSCI.1090-09.2009  1
2009 Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). The Journal of Biological Chemistry. 284: 19402-11. PMID 19478087 DOI: 10.1074/jbc.M109.024711  1
2009 Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. Journal of Medicinal Chemistry. 52: 3892-901. PMID 19469546 DOI: 10.1021/jm9002704  1
2009 Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology. 205: 119-28. PMID 19337725 DOI: 10.1007/s00213-009-1521-8  1
2009 Cho SJ, Jensen NH, Kurome T, Kadari S, Manzano ML, Malberg JE, Caldarone B, Roth BL, Kozikowski AP. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. Journal of Medicinal Chemistry. 52: 1885-902. PMID 19284718 DOI: 10.1021/jm801354e  1
2009 Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Journal of Medicinal Chemistry. 52: 1795-8. PMID 19275170 DOI: 10.1021/jm801652d  1
2009 Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. The Journal of Pharmacology and Experimental Therapeutics. 329: 738-46. PMID 19197004 DOI: 10.1124/jpet.108.146142  1
2009 Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation. Journal of Chemical Information and Modeling. 49: 461-76. PMID 19182860 DOI: 10.1021/ci800366f  1
2009 Sikazwe DM, Nkansah NT, Altundas R, Zhu XY, Roth BL, Setola V, Ablordeppey SY. Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. Bioorganic & Medicinal Chemistry. 17: 1716-23. PMID 19155177 DOI: 10.1016/j.bmc.2008.12.054  1
2009 Strachan RT, Sheffler DJ, Willard B, Kinter M, Kiselar JG, Roth BL. Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling. The Journal of Biological Chemistry. 284: 5557-73. PMID 19103592 DOI: 10.1074/jbc.M805705200  1
2008 Bikbulatov RV, Stewart J, Jin W, Yan F, Roth BL, Ferreira D, Zjawiony JK. Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure. Tetrahedron Letters. 49: 937-940. PMID 19197341 DOI: 10.1016/j.tetlet.2007.12.041  1
2008 Pei Y, Rogan SC, Yan F, Roth BL. Engineered GPCRs as tools to modulate signal transduction. Physiology (Bethesda, Md.). 23: 313-21. PMID 19074739 DOI: 10.1152/physiol.00025.2008  1
2008 Abbas A, Roth BL. Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Expert Opinion On Pharmacotherapy. 9: 3251-9. PMID 19040345 DOI: 10.1517/14656560802532707  1
2008 Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. Journal of Medicinal Chemistry. 51: 6808-28. PMID 18847250 DOI: 10.1021/jm800771x  1
2008 Abbas A, Roth BL. Protein engineering: electrifying cell receptors. Nature Nanotechnology. 3: 587-8. PMID 18838995 DOI: 10.1038/nnano.2008.292  1
2008 Ma ZZ, Xu W, Jensen NH, Roth BL, Liu-Chen LY, Lee DY. Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules (Basel, Switzerland). 13: 2303-12. PMID 18830156 DOI: 10.3390/molecules13092303  1
2008 Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, et al. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry. 16: 8853-62. PMID 18790643 DOI: 10.1016/j.bmc.2008.08.072  1
2008 Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 18: 5268-71. PMID 18774714 DOI: 10.1016/j.bmcl.2008.08.059  1
2008 Basura GJ, Abbas AI, O'Donohue H, Lauder JM, Roth BL, Walker PD, Manis PB. Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex. Hearing Research. 244: 45-50. PMID 18718516 DOI: 10.1016/j.heares.2008.07.009  1
2008 Jensen NH, Roth BL. Massively parallel screening of the receptorome. Combinatorial Chemistry & High Throughput Screening. 11: 420-6. PMID 18673270 DOI: 10.2174/138620708784911483  1
2008 Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nature Methods. 5: 673-8. PMID 18668035 DOI: 10.1038/nmeth.1232  1
2008 Allen JA, Yadav PN, Roth BL. Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases. Neuropharmacology. 55: 961-8. PMID 18640136 DOI: 10.1016/j.neuropharm.2008.06.048  1
2008 Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). Molecular Pharmacology. 74: 1119-31. PMID 18628403 DOI: 10.1124/mol.108.049353  1
2008 Ablordeppey SY, Altundas R, Bricker B, Zhu XY, Kumar EV, Jackson T, Khan A, Roth BL. Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. Bioorganic & Medicinal Chemistry. 16: 7291-301. PMID 18595716 DOI: 10.1016/j.bmc.2008.06.030  1
2008 Wald DN, Vermaat HM, Zang S, Lavik A, Kang Z, Peleg G, Gerson SL, Bunting KD, Agarwal ML, Roth BL, Tse W. Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound. Cancer Research. 68: 4369-76. PMID 18519698 DOI: 10.1158/0008-5472.CAN-07-6559  1
2008 Roth BL. High-dose olanzapine for treatment-resistant schizophrenia. The Journal of Clinical Psychiatry. 69: 176-7. PMID 18363451  1
2008 Conn PJ, Roth BL. Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2048-60. PMID 18216778 DOI: 10.1038/sj.npp.1301638  1
2008 Yan F, Mosier PD, Westkaemper RB, Roth BL. Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors. Biochemistry. 47: 1567-78. PMID 18205395 DOI: 10.1021/bi701476b  1
2008 Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. Journal of Medicinal Chemistry. 51: 603-11. PMID 18201064 DOI: 10.1021/jm070910s  1
2008 Abbas A, Roth BL. Arresting serotonin. Proceedings of the National Academy of Sciences of the United States of America. 105: 831-2. PMID 18195368 DOI: 10.1073/pnas.0711335105  1
2008 Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2303-12. PMID 18059438 DOI: 10.1038/sj.npp.1301646  1
2008 Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. The Journal of Pharmacology and Experimental Therapeutics. 324: 188-95. PMID 17951511 DOI: 10.1124/jpet.107.129023  1
2008 Conn PJ, Roth BL. Opportunities and challenges of psychiatric drug discovery: Roles for scientists in academic, industry, and government settings (Neuropsychopharmacology (2008) DOI: 10.1038/sj.npp.1301638) Neuropsychopharmacology. 33: 2300. DOI: 10.1038/npp.2008.83  1
2008 Xia Z, Roth BL. Novel mechanisms of drug treatment in psychiatry Tthe Medical Basis of Psychiatry: Third Edition. 519-534. DOI: 10.1007/978-1-59745-252-6_30  1
2007 Svenningsson P, Bateup H, Qi H, Takamiya K, Huganir RL, Spedding M, Roth BL, McEwen BS, Greengard P. Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine. The European Journal of Neuroscience. 26: 3509-17. PMID 18088278 DOI: 10.1111/j.1460-9568.2007.05952.x  1
2007 Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C. Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes. Bioorganic & Medicinal Chemistry. 15: 7626-37. PMID 17889543 DOI: 10.1016/j.bmc.2007.09.003  1
2007 Gray JA, Roth BL. The pipeline and future of drug development in schizophrenia. Molecular Psychiatry. 12: 904-22. PMID 17667958 DOI: 10.1038/sj.mp.4002062  1
2007 Gray JA, Roth BL. Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophrenia Bulletin. 33: 1100-19. PMID 17617664 DOI: 10.1093/schbul/sbm074  1
2007 Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proceedings of the National Academy of Sciences of the United States of America. 104: 5163-8. PMID 17360345 DOI: 10.1073/pnas.0700293104  1
2007 Bikbulatov RV, Yan F, Roth BL, Zjawiony JK. Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorganic & Medicinal Chemistry Letters. 17: 2229-32. PMID 17303418 DOI: 10.1016/j.bmcl.2007.01.100  1
2007 Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nature Biotechnology. 25: 197-206. PMID 17287757 DOI: 10.1038/nbt1284  1
2007 Nyandege A, Kolanos R, Roth BL, Glennon RA. Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1691-4. PMID 17239595 DOI: 10.1016/j.bmcl.2006.12.089  1
2007 Vortherms TA, Mosier PD, Westkaemper RB, Roth BL. Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. The Journal of Biological Chemistry. 282: 3146-56. PMID 17121830 DOI: 10.1074/jbc.M609264200  1
2007 Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/jpet.106.104463  1
2006 Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. The Journal of Organic Chemistry. 71: 8934-45. PMID 17081025 DOI: 10.1021/jo061758p  1
2006 Vortherms TA, Roth BL. Salvinorin A: from natural product to human therapeutics. Molecular Interventions. 6: 257-65. PMID 17035666 DOI: 10.1124/mi.6.5.7  1
2006 Kolanos R, Dukat M, Roth BL, Glennon RA. Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5832-5. PMID 16945532 DOI: 10.1016/j.bmcl.2006.08.068  1
2006 Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology. 188: 244-51. PMID 16915381 DOI: 10.1007/s00213-006-0490-4  1
2006 Sikazwe D, Bondarev ML, Dukat M, Rangisetty JB, Roth BL, Glennon RA. Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. Journal of Medicinal Chemistry. 49: 5217-25. PMID 16913710 DOI: 10.1021/jm060469q  1
2006 Strachan RT, Ferrara G, Roth BL. Screening the receptorome: an efficient approach for drug discovery and target validation. Drug Discovery Today. 11: 708-16. PMID 16846798 DOI: 10.1016/j.drudis.2006.06.012  0.52
2006 Kroeze WK, Roth BL. Screening the receptorome. Journal of Psychopharmacology (Oxford, England). 20: 41-6. PMID 16785269 DOI: 10.1177/1359786806066045  0.52
2006 Stewart DJ, Fahmy H, Roth BL, Yan F, Zjawiony JK. Bioisosteric modification of salvinorin A, a potent and selective kappa-opioid receptor agonist. Arzneimittel-Forschung. 56: 269-75. PMID 16724512 DOI: 10.1055/s-0031-1296720  1
2006 Roth BL, Kroeze WK. Screening the receptorome yields validated molecular targets for drug discovery. Current Pharmaceutical Design. 12: 1785-95. PMID 16712488  0.52
2006 Siripurapu U, Kolanos R, Dukat M, Roth BL, Glennon RA. Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 3793-6. PMID 16709453 DOI: 10.1016/j.bmcl.2006.04.094  1
2006 Ansonoff MA, Zhang J, Czyzyk T, Rothman RB, Stewart J, Xu H, Zjwiony J, Siebert DJ, Yang F, Roth BL, Pintar JE. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 318: 641-8. PMID 16672569 DOI: 10.1124/jpet.106.101998  1
2006 Ablordeppey SY, Lyles-Eggleston M, Bricker B, Zhang W, Zhu X, Goodman C, Roth BL. Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol. Bioorganic & Medicinal Chemistry Letters. 16: 3219-23. PMID 16621538 DOI: 10.1016/j.bmcl.2006.03.057  0.64
2006 Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 103: 4717-22. PMID 16537434 DOI: 10.1073/pnas.0600585103  1
2006 Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. Journal of Medicinal Chemistry. 49: 1080-100. PMID 16451073 DOI: 10.1021/jm050570f  1
2006 Kushwaha N, Harwood SC, Wilson AM, Berger M, Tecott LH, Roth BL, Albert PR. Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. Molecular Pharmacology. 69: 1518-26. PMID 16410407 DOI: 10.1124/mol.105.019844  1
2006 Davies MA, Setola V, Strachan RT, Sheffler DJ, Salay E, Hufeisen SJ, Roth BL. Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies. The Pharmacogenomics Journal. 6: 42-51. PMID 16314884 DOI: 10.1038/sj.tpj.6500342  1
2006 Pehek EA, Nocjar C, Roth BL, Byrd TA, Mabrouk OS. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 265-77. PMID 15999145 DOI: 10.1038/sj.npp.1300819  1
2005 Setola V, Roth BL. Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. Expert Opinion On Drug Metabolism & Toxicology. 1: 377-87. PMID 16863450 DOI: 10.1517/17425255.1.3.377  1
2005 O'Connor KA, Roth BL. Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nature Reviews. Drug Discovery. 4: 1005-14. PMID 16341065 DOI: 10.1038/nrd1900  1
2005 Munro TA, Goetchius GW, Roth BL, Vortherms TA, Rizzacasa MA. Autoxidation of salvinorin A under basic conditions. The Journal of Organic Chemistry. 70: 10057-61. PMID 16292839 DOI: 10.1021/jo051813e  1
2005 O'Connor KA, Roth BL. Screening the receptorome for plant-based psychoactive compounds. Life Sciences. 78: 506-11. PMID 16213532 DOI: 10.1016/j.lfs.2005.09.002  1
2005 Pullagurla M, Siripurapu U, Kolanos R, Bondarev ML, Dukat M, Setola V, Roth BL, Glennon RA. Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 15: 5298-302. PMID 16183286 DOI: 10.1016/j.bmcl.2005.08.059  1
2005 Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. Journal of Combinatorial Chemistry. 7: 673-81. PMID 16153061 DOI: 10.1021/cc050064b  1
2005 Sard H, Kumaran G, Morency C, Roth BL, Toth BA, He P, Shuster L. SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorganic & Medicinal Chemistry Letters. 15: 4555-9. PMID 16061378 DOI: 10.1016/j.bmcl.2005.06.104  0.4
2005 Abate C, Kolanos R, Dukat M, Setola V, Roth BL, Glennon RA. Interaction of chiral MS-245 analogs at h5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters. 15: 3510-3. PMID 15990303 DOI: 10.1016/j.bmcl.2005.05.092  1
2005 Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors. Biochemistry. 44: 8643-51. PMID 15952771 DOI: 10.1021/bi050490d  1
2005 Vortherms TA, Roth BL. Receptorome screening for CNS drug discovery. Idrugs : the Investigational Drugs Journal. 8: 491-6. PMID 15906196  1
2005 Setola V, Dukat M, Glennon RA, Roth BL. Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor. Molecular Pharmacology. 68: 20-33. PMID 15831837 DOI: 10.1124/mol.104.009266  1
2005 Kolanos R, Siripurapu U, Pullagurla M, Riaz M, Setola V, Roth BL, Dukat M, Glennon RA. Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 15: 1987-91. PMID 15808453 DOI: 10.1016/j.bmcl.2005.02.070  1
2005 Davies MA, Compton-Toth BA, Hufeisen SJ, Meltzer HY, Roth BL. The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions? Psychopharmacology. 178: 451-60. PMID 15765260 DOI: 10.1007/s00213-004-2017-1  0.92
2005 Rothman RB, Blough BE, Woolverton WL, Anderson KG, Negus SS, Mello NK, Roth BL, Baumann MH. Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration. The Journal of Pharmacology and Experimental Therapeutics. 313: 1361-9. PMID 15761112 DOI: 10.1124/jpet.104.082503  1
2005 Lee M, Rangisetty JB, Pullagurla MR, Dukat M, Setola V, Roth BL, Glennon RA. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorganic & Medicinal Chemistry Letters. 15: 1707-11. PMID 15745826 DOI: 10.1016/j.bmcl.2005.01.031  1
2005 Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 45: 489-96. PMID 15721235 DOI: 10.1016/j.neuron.2005.01.041  1
2005 Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP. Bioorganic & Medicinal Chemistry Letters. 15: 945-9. PMID 15686891 DOI: 10.1016/j.bmcl.2004.12.047  1
2005 Munro TA, Rizzacasa MA, Roth BL, Toth BA, Yan F. Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. Journal of Medicinal Chemistry. 48: 345-8. PMID 15658846 DOI: 10.1021/jm049438q  1
2005 Armbruster BN, Roth BL. Mining the receptorome. The Journal of Biological Chemistry. 280: 5129-32. PMID 15590622 DOI: 10.1074/jbc.R400030200  1
2005 Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity. Bioorganic & Medicinal Chemistry. 13: 197-209. PMID 15582465 DOI: 10.1016/j.bmc.2004.09.042  1
2004 Roth BL, Xia Z. Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis. Critical Reviews in Neurobiology. 16: 229-36. PMID 15862107 DOI: 10.1615/CritRevNeurobiol.v16.i4.10  1
2004 Davies MA, Sheffler DJ, Roth BL. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. Cns Drug Reviews. 10: 317-36. PMID 15592581  1
2004 Karolewicz B, Szebeni K, Stockmeier CA, Konick L, Overholser JC, Jurjus G, Roth BL, Ordway GA. Low nNOS protein in the locus coeruleus in major depression. Journal of Neurochemistry. 91: 1057-66. PMID 15569249 DOI: 10.1111/j.1471-4159.2004.02792.x  1
2004 Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science (New York, N.Y.). 306: 1380-3. PMID 15550673 DOI: 10.1126/science.1103492  1
2004 Sikazwe DM, Li S, Mardenborough L, Cody V, Roth BL, Ablordeppey SY. Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors. Bioorganic & Medicinal Chemistry Letters. 14: 5739-42. PMID 15501032 DOI: 10.1016/j.bmcl.2004.09.046  0.64
2004 Yan F, Roth BL. Salvinorin A: a novel and highly selective kappa-opioid receptor agonist. Life Sciences. 75: 2615-9. PMID 15369697 DOI: 10.1016/j.lfs.2004.07.008  1
2004 Quirk PL, Rao S, Roth BL, Siegel RE. Three putative N-glycosylation sites within the murine 5-HT3A receptor sequence affect plasma membrane targeting, ligand binding, and calcium influx in heterologous mammalian cells. Journal of Neuroscience Research. 77: 498-506. PMID 15264219 DOI: 10.1002/jnr.20185  1
2004 Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. The Journal of Biological Chemistry. 279: 34614-23. PMID 15190056 DOI: 10.1074/jbc.M404673200  1
2004 Roth BL, Lopez E, Beischel S, Westkaemper RB, Evans JM. Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacology & Therapeutics. 102: 99-110. PMID 15163592 DOI: 10.1016/j.pharmthera.2004.03.004  1
2004 Petrie KA, Bubser M, Casey CD, Davis MD, Roth BL, Deutch AY. The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1878-88. PMID 15150532 DOI: 10.1038/sj.npp.1300494  1
2004 Peddi S, Roth BL, Glennon RA, Westkaemper RB. Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA). Bioorganic & Medicinal Chemistry Letters. 14: 2279-83. PMID 15081025 DOI: 10.1016/j.bmcl.2004.02.014  1
2004 Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Reviews. Drug Discovery. 3: 353-9. PMID 15060530 DOI: 10.1038/nrd1346  0.64
2004 Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. The Journal of Pharmacology and Experimental Therapeutics. 308: 1197-203. PMID 14718611 DOI: 10.1124/jpet.103.059394  1
2003 Piletz JE, Deleersnijder W, Roth BL, Ernsberger P, Zhu H, Ziegler D. IRAS splice variants. Annals of the New York Academy of Sciences. 1009: 419-26. PMID 15028621  0.6
2003 Shi Q, Hufeisen SJ, Wroblewski JT, Nadeau JH, Roth BL. L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons. Annals of the New York Academy of Sciences. 1003: 461-3. PMID 14684489 DOI: 10.1196/annals.1300.054  1
2003 Peddi S, Roth BL, Glennon RA, Westkaemper RB. Spiro[9,10-dihydroanthracene]-9,3'-pyrrolidine-a structurally unique tetracyclic 5-HT2A receptor antagonist. European Journal of Pharmacology. 482: 335-7. PMID 14660041 DOI: 10.1016/j.ejphar.2003.09.059  1
2003 Setola V, Roth BL. Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants. Molecular Pharmacology. 64: 1277-8. PMID 14645656 DOI: 10.1124/mol.64.6.1277  1
2003 Xia Z, Hufeisen SJ, Gray JA, Roth BL. The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience. 122: 907-20. PMID 14643760 DOI: 10.1016/S0306-4522(03)00589-X  1
2003 Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. Journal of Cell Science. 116: 4867-9. PMID 14625380 DOI: 10.1242/jcs.00902  1
2003 De Amici M, Conti P, Fasoli E, Barocelli E, Ballabeni V, Bertoni S, Impicciatore M, Roth BL, Ernsberger P, De Micheli C. Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands. Farmaco (Società Chimica Italiana : 1989). 58: 739-48. PMID 13679167  0.36
2003 Gray JA, Compton-Toth BA, Roth BL. Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry. 42: 10853-62. PMID 12962510 DOI: 10.1021/bi035061z  1
2003 Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, Glennon RA. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. The Journal of Pharmacology and Experimental Therapeutics. 307: 138-45. PMID 12954796 DOI: 10.1124/jpet.103.053975  1
2003 Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. The Journal of Biological Chemistry. 278: 43628-35. PMID 12930822 DOI: 10.1074/jbc.M308947200  1
2003 Peddi S, Roth BL, Glennon RA, Westkaemper RB. Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 13: 2565-8. PMID 12852967 DOI: 10.1016/S0960-894X(03)00504-3  1
2003 Shapiro DA, Renock S, Arrington E, Chiodo LA, Liu LX, Sibley DR, Roth BL, Mailman R. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1400-11. PMID 12784105 DOI: 10.1038/sj.npp.1300203  1
2003 Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL. 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Molecular Pharmacology. 63: 1223-9. PMID 12761331 DOI: 10.1124/mol.63.6.1223  1
2003 Gray JA, Bhatnagar A, Gurevich VV, Roth BL. The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization. Molecular Pharmacology. 63: 961-72. PMID 12695524 DOI: 10.1124/mol.63.5.961  1
2003 Xia Z, Gray JA, Compton-Toth BA, Roth BL. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. The Journal of Biological Chemistry. 278: 21901-8. PMID 12682061 DOI: 10.1074/jbc.M301905200  1
2003 Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 305: 131-42. PMID 12649361 DOI: 10.1124/jpet.102.047092  1
2003 Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 519-26. PMID 12629531 DOI: 10.1038/sj.npp.1300027  0.92
2003 Sheffler DJ, Roth BL. Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. Trends in Pharmacological Sciences. 24: 107-9. PMID 12628350 DOI: 10.1016/S0165-6147(03)00027-0  1
2003 Faden AI, Knoblach SM, Cernak I, Fan L, Vink R, Araldi GL, Fricke ST, Roth BL, Kozikowski AP. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 342-54. PMID 12621309  1
2002 Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences of the United States of America. 99: 11934-9. PMID 12192085 DOI: 10.1073/pnas.182234399  0.36
2002 Gray JA, Roth BL. Cell biology. A last GASP for GPCRs? Science (New York, N.Y.). 297: 529-31. PMID 12142517 DOI: 10.1126/science.1075453  1
2002 Cornea-Hébert V, Watkins KC, Roth BL, Kroeze WK, Gaudreau P, Leclerc N, Descarries L. Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat. Neuroscience. 113: 23-35. PMID 12123681 DOI: 10.1016/S0306-4522(02)00146-X  1
2002 Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J, Popadak B, Ernsberger P, Roth BL. In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. Psychopharmacology. 162: 193-202. PMID 12110997 DOI: 10.1007/s00213-002-1073-7  0.44
2002 Kroeze WK, Kristiansen K, Roth BL. Molecular biology of serotonin receptors structure and function at the molecular level. Current Topics in Medicinal Chemistry. 2: 507-28. PMID 12052191  0.52
2002 Nocjar C, Roth BL, Pehek EA. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. 111: 163-76. PMID 11955720 DOI: 10.1016/S0306-4522(01)00593-0  1
2002 Runyon SP, Peddi S, Savage JE, Roth BL, Glennon RA, Westkaemper RB. Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Journal of Medicinal Chemistry. 45: 1656-64. PMID 11931619 DOI: 10.1021/jm010354g  1
2002 Shapiro DA, Kristiansen K, Weiner DM, Kroeze WK, Roth BL. Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. The Journal of Biological Chemistry. 277: 11441-9. PMID 11801601 DOI: 10.1074/jbc.M111675200  1
2001 Gray JA, Roth BL. Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Research Bulletin. 56: 441-51. PMID 11750789 DOI: 10.1016/S0361-9230(01)00623-2  1
2001 Martín-Ruiz R, Puig MV, Celada P, Shapiro DA, Roth BL, Mengod G, Artigas F. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9856-66. PMID 11739593  1
2001 Gray JA, Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, Roth BL. Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Molecular Pharmacology. 60: 1020-30. PMID 11641430  1
2001 Rauser L, Savage JE, Meltzer HY, Roth BL. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. The Journal of Pharmacology and Experimental Therapeutics. 299: 83-9. PMID 11561066  0.64
2001 Roth BL, Ernsberger P, Steinberg SA, Rao S, Rauser L, Savage J, Hufeisen S, Berridge MS, Muzic RF. The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology. 157: 111-4. PMID 11512051 DOI: 10.1007/s002130100844  1
2001 Huang Y, Kegeles LS, Bae S, Hwang D, Roth BL, Savage JE, Laruelle M. Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. Bioorganic & Medicinal Chemistry Letters. 11: 1375-7. PMID 11378358  0.36
2001 Qiao L, Zhao LY, Rong SB, Wu XW, Wang S, Fujii T, Kazanietz MG, Rauser L, Savage J, Roth BL, Flippen-Anderson J, Kozikowski AP. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. Bioorganic & Medicinal Chemistry Letters. 11: 955-9. PMID 11327599 DOI: 10.1016/S0960-894X(01)00097-X  1
2001 Runyon SP, Savage JE, Taroua M, Roth BL, Glennon RA, Westkaemper RB. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorganic & Medicinal Chemistry Letters. 11: 655-8. PMID 11266163 DOI: 10.1016/S0960-894X(01)00023-3  1
2001 Westkaemper RB, Runyon SP, Savage JE, Roth BL, Glennon RA. Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor. Bioorganic & Medicinal Chemistry Letters. 11: 563-6. PMID 11229772 DOI: 10.1016/S0960-894X(01)00010-5  1
2001 Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Molecular Pharmacology. 59: 427-33. PMID 11179435  1
2001 Bubser M, Backstrom JR, Sanders-Bush E, Roth BL, Deutch AY. Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Synapse (New York, N.Y.). 39: 297-304. PMID 11169779 DOI: 10.1002/1098-2396(20010315)39:4<297::AID-SYN1012>3.0.CO;2-Q  1
2001 Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. The Journal of Biological Chemistry. 276: 8269-77. PMID 11069907 DOI: 10.1074/jbc.M006968200  1
2000 Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 102: 2836-41. PMID 11104741  0.92
2000 Tsai Y, Dukat M, Slassi A, MacLean N, Demchyshyn L, Savage JE, Roth BL, Hufesein S, Lee M, Glennon RA. N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. Bioorganic & Medicinal Chemistry Letters. 10: 2295-9. PMID 11055342 DOI: 10.1016/S0960-894X(00)00453-4  1
2000 Shapiro DA, Kristiansen K, Kroeze WK, Roth BL. Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. Molecular Pharmacology. 58: 877-86. PMID 11040033  0.52
2000 Kristiansen K, Kroeze WK, Willins DL, Gelber EI, Savage JE, Glennon RA, Roth BL. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism. The Journal of Pharmacology and Experimental Therapeutics. 293: 735-46. PMID 10869371  1
2000 Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. Journal of Medicinal Chemistry. 43: 1011-8. PMID 10715164 DOI: 10.1021/jm990550b  1
2000 Egan C, Grinde E, Dupre A, Roth BL, Hake M, Teitler M, Herrick-Davis K. Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. Synapse (New York, N.Y.). 35: 144-50. PMID 10611640 DOI: 10.1002/(SICI)1098-2396(200002)35:2<144::AID-SYN7>3.0.CO;2-K  1
1999 Westkaemper RB, Runyon SP, Bondarev ML, Savage JE, Roth BL, Glennon RA. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist. European Journal of Pharmacology. 380: R5-7. PMID 10513561 DOI: 10.1016/S0014-2999(99)00525-7  1
1999 Roth BL, Willins DL. What's all the RAVE about receptor internalization? Neuron. 23: 629-31. PMID 10482227  0.48
1999 Willins DL, Berry SA, Alsayegh L, Backstrom JR, Sanders-Bush E, Friedman L, Roth BL. Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo. Neuroscience. 91: 599-606. PMID 10366017 DOI: 10.1016/S0306-4522(98)00653-8  1
1999 Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY, Overholser JC, Roth BL, Stockmeier CA. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biological Psychiatry. 45: 1085-98. PMID 10331101 DOI: 10.1016/S0006-3223(99)00041-4  1
1999 Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic J, Roth BL. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. Journal of Neurochemistry. 72: 2206-14. PMID 10217304 DOI: 10.1046/j.1471-4159.1999.0722206.x  1
1998 Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K. Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Critical Reviews in Neurobiology. 12: 319-38. PMID 10348614  0.52
1998 Willins DL, Alsayegh L, Berry SA, Backstrom JR, Sanders-Bush E, Friedman L, Khan N, Roth BL. Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo. Annals of the New York Academy of Sciences. 861: 121-7. PMID 9928248 DOI: 10.1111/j.1749-6632.1998.tb10182.x  1
1998 Kroeze WK, Roth BL. The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis. Biological Psychiatry. 44: 1128-42. PMID 9836016  0.52
1998 Roth BL, Willins DL, Kristiansen K, Kroeze WK. 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacology & Therapeutics. 79: 231-57. PMID 9776378  0.52
1998 Roth BL, Willins DL, Kroeze WK. G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse. Drug and Alcohol Dependence. 51: 73-85. PMID 9716931  0.52
1998 Roth BL, Meltzer HY, Khan N. Binding of typical and atypical antipsychotic drugs to multiple neurotransmitter receptors. Advances in Pharmacology (San Diego, Calif.). 42: 482-5. PMID 9327944  0.64
1993 Ciaranello RD, Aimi J, Dean R, Desai R, Garlow S, Heller MR, Morilak D, Roth BL. Developmental regulation of 5-HT2 and 5-HT1c receptor gene expression in rat brain. Psychopharmacology Series. 10: 26-37. PMID 8361980  1
1993 Garlow SJ, Morilak DA, Dean RR, Roth BL, Ciaranello RD. Production and characterization of a specific 5-HT2 receptor antibody. Brain Research. 615: 113-20. PMID 7689908 DOI: 10.1016/0006-8993(93)91121-8  1
1992 Roth BL, Ciaranello RD, Meltzer HY. Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. The Journal of Pharmacology and Experimental Therapeutics. 260: 1361-5. PMID 1347569  1
1991 Roth BL, Hamblin MW, Ciaranello RD. Developmental regulation of 5-HT2 and 5-HT1c mRNA and receptor levels. Brain Research. Developmental Brain Research. 58: 51-8. PMID 2015654 DOI: 10.1016/0165-3806(91)90236-C  1
1991 Roth BL, Ciaranello RD. Chronic mianserin treatment decreases 5-HT2 receptor binding without altering 5-HT2 receptor mRNA levels. European Journal of Pharmacology. 207: 169-72. PMID 1879460 DOI: 10.1016/0922-4106(91)90093-W  1
1990 Roth BL, Hamblin M, Ciaranello RD. Regulation of 5-HT2 and 5-HT1C serotonin receptor levels. Methodology and mechanisms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 3: 427-33. PMID 2078277  1
1989 McLean S, Rothman RB, Chuang DM, Rice KC, Spain JW, Coscia CJ, Roth BL. Cross-linking of [125I]beta-endorphin to mu-opioid receptors during development. Brain Research. Developmental Brain Research. 45: 283-9. PMID 2540924 DOI: 10.1016/0165-3806(89)90046-1  1
1986 Chuang DM, Dillon-Carter O, Spain JW, Laskowski MB, Roth BL, Coscia CJ. Detection and characterization of beta-adrenergic receptors and adenylate cyclase in coated vesicles isolated from bovine brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 2578-84. PMID 3018196  1
1986 Roth BL, Nakaki T, Chuang DM, Costa E. 5-Hydroxytryptamine2 receptors coupled to phospholipase C in rat aorta: modulation of phosphoinositide turnover by phorbol ester. The Journal of Pharmacology and Experimental Therapeutics. 238: 480-5. PMID 3016238  0.48
1986 Nicoletti F, Meek JL, Iadarola MJ, Chuang DM, Roth BL, Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. Journal of Neurochemistry. 46: 40-6. PMID 2866236  1
1985 Roth BL, Nakaki T, Chuang DM, Costa E. Evidence for an endacoid for the 5HT2 recognition site. Progress in Clinical and Biological Research. 192: 473-6. PMID 4080717  0.48
1985 Nakaki T, Roth BL, Chuang DM, Costa E. 5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells. Journal of Neurochemistry. 45: 920-5. PMID 3875688  0.48
1985 Spain JW, Roth BL, Coscia CJ. Differential ontogeny of multiple opioid receptors (mu, delta, and kappa). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 584-8. PMID 2983043  1
1985 Bennett DB, Spain JW, Laskowski MB, Roth BL, Coscia CJ. Stereospecific opiate-binding sites occur in coated vesicles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 3010-5. PMID 2865342  1
1985 Nakaki T, Roth BL, Chuang DM, Costa E. Phasic and tonic components in 5-HT2 receptor-mediated rat aorta contraction: participation of Ca++ channels and phospholipase C. The Journal of Pharmacology and Experimental Therapeutics. 234: 442-6. PMID 2410594  0.48
1984 Roth BL, Nakaki T, Chuang DM, Costa E. Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacology. 23: 1223-5. PMID 6521858  0.48
1984 Roth BL, Coscia CJ. Microsomal opiate receptors: characterization of smooth microsomal and synaptic membrane opiate receptors. Journal of Neurochemistry. 42: 1677-84. PMID 6327910  1
1984 Scheibe SD, Bennett DB, Spain JW, Roth BL, Coscia CJ. Kinetic evidence for differential agonist and antagonist binding to bovine hippocampal synaptic membrane opioid receptors. The Journal of Biological Chemistry. 259: 13298-303. PMID 6092373  1
1983 Spain JW, Bennett DB, Roth BL, Coscia CJ. Ontogeny of benzomorphan-selective (kappa) sites: a computerized analysis. Life Sciences. 33: 235-8. PMID 6141487 DOI: 10.1016/0024-3205(83)90486-1  1
1982 Roth BL, Laskowski MB, Coscia CJ. Microsomal opiate receptors differ from synaptic membrane receptors in proteolytic sensitivity. Brain Research. 250: 101-9. PMID 6291719 DOI: 10.1016/0006-8993(82)90956-8  1
1982 Pryhuber KG, Roth BL, Coscia CJ. Demonstration of a slowly dissociating form of bovine hippocampal synaptic membrane opiate receptors. European Journal of Pharmacology. 83: 47-53. PMID 6290246 DOI: 10.1016/0014-2999(82)90284-9  1
1982 Wohltmann M, Roth BL, Coscia CJ. Differential postnatal development of mu and delta opiate receptors. Brain Research. 255: 679-84. PMID 6280810 DOI: 10.1016/0165-3806(82)90066-9  1
1981 Roth BL, Laskowski MB, Coscia CJ. Evidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain. The Journal of Biological Chemistry. 256: 10017-23. PMID 6268622  1
1981 Galloway MP, Roth BL, Coscia CJ. The effects of tetrahydroisoquinolinecarboxylic acids in tyrosine 3-monooxygenase. Archives of Biochemistry and Biophysics. 209: 620-7. PMID 6117253 DOI: 10.1016/0003-9861(81)90321-0  1
1980 Roth BL, Galloway MP, Coscia CJ. The effects of morphine on catecholamine metabolism during postnatal development. Brain Research. 197: 561-4. PMID 7407575 DOI: 10.1016/0006-8993(80)91147-6  1
1980 Coscia CJ, Burke WJ, Galloway MP, Kosloff AH, Lasala JM, McFarlane J, Mitchell JS, O'Toole MM, Roth BL. Effects of norlaudanosolinecarboxylic acids on enzymes of catecholamine metabolism. The Journal of Pharmacology and Experimental Therapeutics. 212: 91-6. PMID 6101345  1
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