Roberto Zoncu, Ph.D. - Publications

Molecular and Cell Biology University of California, Berkeley, Berkeley, CA 
 2007 Yale University, New Haven, CT 
How organelles sense nutrients and regulate cellular growth

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, ... ... Zoncu R, et al. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science (New York, N.Y.). 356: 1188-1192. PMID 28619945 DOI: 10.1126/science.aag2553  0.48
2017 Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science (New York, N.Y.). 355: 1306-1311. PMID 28336668 DOI: 10.1126/science.aag1417  0.48
2016 Perera RM, Zoncu R. The Lysosome as a Regulatory Hub. Annual Review of Cell and Developmental Biology. PMID 27501449 DOI: 10.1146/annurev-cellbio-111315-125125  0.48
2015 Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, ... ... Zoncu R, et al. Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics. PMID 26691987 DOI: 10.1038/ng.3473  0.48
2015 Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. Identification of an oncogenic RAB protein. Science (New York, N.Y.). 350: 211-7. PMID 26338797 DOI: 10.1126/science.aaa4903  0.48
2015 Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524: 361-5. PMID 26168401 DOI: 10.1038/nature14587  0.48
2015 Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science (New York, N.Y.). 348: 340-3. PMID 25837514 DOI: 10.1126/science.1260384  0.48
2015 Tooze S, Zoncu R. Control of cellular homeostasis: organelles take the pilot's seat. Molecular Biology of the Cell. 26: 1009-10. PMID 25767200 DOI: 10.1091/mbc.E14-12-1589  0.48
2015 Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (New York, N.Y.). 347: 188-94. PMID 25567906 DOI: 10.1126/science.1257132  0.48
2013 Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Molecular Cell. 52: 495-505. PMID 24095279 DOI: 10.1016/j.molcel.2013.09.016  0.48
2013 Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nature Biotechnology. 31: 653-8. PMID 23792629 DOI: 10.1038/nbt.2614  0.48
2013 Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 493: 679-83. PMID 23263183 DOI: 10.1038/nature11745  0.48
2012 Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 150: 1196-208. PMID 22980980 DOI: 10.1016/j.cell.2012.07.032  0.48
2012 Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1: from lysosomes to disease. Trends in Molecular Medicine. 18: 524-33. PMID 22749019 DOI: 10.1016/j.molmed.2012.05.007  0.48
2012 Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. The Embo Journal. 31: 1095-108. PMID 22343943 DOI: 10.1038/emboj.2012.32  0.48
2011 Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (New York, N.Y.). 334: 678-83. PMID 22053050 DOI: 10.1126/science.1207056  0.48
2011 Zoncu R, Sabatini DM. Cell biology. The TASCC of secretion. Science (New York, N.Y.). 332: 923-5. PMID 21596981 DOI: 10.1126/science.1207552  0.48
2011 Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 19: 613-28. PMID 21575862 DOI: 10.1016/j.ccr.2011.03.012  0.48
2011 Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Reviews. Molecular Cell Biology. 12: 21-35. PMID 21157483 DOI: 10.1038/nrm3025  0.48
2010 Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. The Journal of Cell Biology. 190: 307-15. PMID 20679431 DOI: 10.1083/jcb.201005018  0.48
2010 Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 141: 290-303. PMID 20381137 DOI: 10.1016/j.cell.2010.02.024  0.48
2009 Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. The Embo Journal. 28: 1831-42. PMID 19536138 DOI: 10.1038/emboj.2009.155  0.48
2009 Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 136: 1110-21. PMID 19303853 DOI: 10.1016/j.cell.2009.01.032  0.48
2008 Díaz ME, Ayala G, León T, Zoncu R, Toomre D. Analyzing protein-protein spatial-temporal dependencies from image sequences using fuzzy temporal random sets. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 15: 1221-36. PMID 18973437 DOI: 10.1089/cmb.2008.0055  0.48
2008 Díaz E, Sebastian R, Ayala G, Díaz ME, Zoncu R, Toomre D, Gasman S. Measuring spatiotemporal dependencies in bivariate temporal random sets with applications to cell biology. Ieee Transactions On Pattern Analysis and Machine Intelligence. 30: 1659-71. PMID 18617722 DOI: 10.1109/TPAMI.2007.70821  0.48
2007 Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM. Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody. Neoplasia (New York, N.Y.). 9: 1099-110. PMID 18084617 DOI: 10.1593/neo.07721  0.48
2007 Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P. A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Developmental Cell. 13: 377-90. PMID 17765681 DOI: 10.1016/j.devcel.2007.08.004  0.48
2007 Zoncu R, Perera RM, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli PV. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proceedings of the National Academy of Sciences of the United States of America. 104: 3793-8. PMID 17360432 DOI: 10.1073/pnas.0611733104  0.48
2007 Sebastian R, Ayala G, Diaz ME, Zoncu R, Toomre D. Estimating the duration of endocytic events 2007 4th Ieee International Symposium On Biomedical Imaging: From Nano to Macro - Proceedings. 248-251. DOI: 10.1109/ISBI.2007.356835  0.48
2007 León T, Sebastian R, Ayala G, Díaz ME, Zoncu R, Toomre D. Fuzzy temporal random sets with an application to cell biology Ieee International Conference On Fuzzy Systems. DOI: 10.1109/FUZZY.2007.4295484  0.48
2006 Sebastian R, Diaz ME, Ayala G, Zoncu R, Toomre D. Analysis of spatial dependencies of endocytic proteins based on temporal random sets. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 4175-8. PMID 17946228 DOI: 10.1109/IEMBS.2006.260479  0.48
2006 Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proceedings of the National Academy of Sciences of the United States of America. 103: 19332-7. PMID 17158794 DOI: 10.1073/pnas.0609795104  0.48
2006 Ayala G, Sebastian R, Díaz ME, Díaz E, Zoncu R, Toomre D. Overlapping events with application to image sequences. Ieee Transactions On Pattern Analysis and Machine Intelligence. 28: 1707-12. PMID 16986551 DOI: 10.1109/TPAMI.2006.199  0.48
2006 Sebastian R, Díaz E, Ayala G, Díaz ME, Zoncu R, Toomre D. Studying endocytosis in space and time by means of temporal Boolean models Pattern Recognition. 39: 2175-2185. DOI: 10.1016/j.patcog.2006.04.030  0.48
2002 Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature. 420: 85-9. PMID 12422219 DOI: 10.1038/nature01147  0.48
2002 Letinic K, Zoncu R, Rakic P. Origin of GABAergic neurons in the human neocortex. Nature. 417: 645-9. PMID 12050665 DOI: 10.1038/nature00779  0.48
2001 Biagioli M, Wätjen W, Beyersmann D, Zoncu R, Cappellini C, Ragghianti M, Cremisi F, Bucci S. Cadmium-induced apoptosis in murine fibroblasts is suppressed by Bcl-2. Archives of Toxicology. 75: 313-20. PMID 11570688 DOI: 10.1007/s002040100236  0.48
2000 Malatesta P, Götz M, Barsacchi G, Price J, Zoncu R, Cremisi F. PC3 overexpression affects the pattern of cell division of rat cortical precursors. Mechanisms of Development. 90: 17-28. PMID 10585559 DOI: 10.1016/S0925-4773(99)00224-5  0.48
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