Michael J. Gandal, MD PhD - Publications

Psychiatry University of California, Los Angeles, Los Angeles, CA 
Neurogenetics, Systems Biology, Psychiatric Disease

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Berto S, Treacher AH, Caglayan E, Luo D, Haney JR, Gandal MJ, Geschwind DH, Montillo AA, Konopka G. Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder. Nature Communications. 13: 3328. PMID 35680911 DOI: 10.1038/s41467-022-31053-5  0.686
2022 Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, ... ... Gandal MJ, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. PMID 35396580 DOI: 10.1038/s41586-022-04434-5  0.358
2021 Krebs MD, Themudo GE, Benros ME, Mors O, Børglum AD, Hougaard D, Mortensen PB, Nordentoft M, Gandal MJ, Fan CC, Geschwind DH, Schork AJ, Werge T, Thompson WK. Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors. Nature Communications. 12: 6617. PMID 34785645 DOI: 10.1038/s41467-021-26903-7  0.485
2021 Vlasova RM, Iosif AM, Ryan AM, Funk LH, Murai T, Chen S, Lesh TA, Rowland DJ, Bennett J, Hogrefe CE, Maddock RJ, Gandal MJ, Geschwind DH, Schumann CM, Van de Water J, et al. Maternal immune activation during pregnancy alters postnatal brain growth and cognitive development in nonhuman primate offspring. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34607967 DOI: 10.1523/JNEUROSCI.0378-21.2021  0.421
2021 López-Aranda MF, Chattopadhyay I, Boxx GM, Fraley ER, Silva TK, Zhou M, Phan M, Herrera I, Taloma S, Mandanas R, Bach K, Gandal M, Geschwind DH, Cheng G, Rzhetsky A, et al. Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications. Science Advances. 7: eabf2073. PMID 34533985 DOI: 10.1126/sciadv.abf2073  0.381
2021 Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics. PMID 34002096 DOI: 10.1038/s41588-021-00857-4  0.371
2021 Gandal MJ, Geschwind DH. Polygenicity in Psychiatry-Like It or Not, We Have to Understand It. Biological Psychiatry. 89: 2-4. PMID 33272361 DOI: 10.1016/j.biopsych.2020.10.002  0.411
2020 Page NF, Gandal MJ, Estes ML, Cameron S, Buth J, Parhami S, Ramaswami G, Murray K, Amaral DG, Van de Water JA, Schumann CM, Carter CS, Bauman MD, McAllister AK, Geschwind DH. Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates. Biological Psychiatry. PMID 33386132 DOI: 10.1016/j.biopsych.2020.10.016  0.491
2020 Ramaswami G, Won H, Gandal MJ, Haney J, Wang JC, Wong CCY, Sun W, Prabhakar S, Mill J, Geschwind DH. Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Nature Communications. 11: 4873. PMID 32978376 DOI: 10.1038/s41467-020-18526-1  0.564
2020 Hernandez LM, Kim M, Hoftman GD, Haney JR, de la Torre-Ubieta L, Pasaniuc B, Gandal MJ. Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders. Biological Psychiatry. PMID 32792264 DOI: 10.1016/j.biopsych.2020.06.005  0.513
2020 Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 181: 745. PMID 32359439 DOI: 10.1016/j.cell.2020.04.016  0.601
2020 Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 181: 484. PMID 32302575 DOI: 10.1016/j.cell.2020.04.003  0.601
2020 Dahl A, Nguyen K, Cai N, Gandal MJ, Flint J, Zaitlen N. A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. American Journal of Human Genetics. 106: 71-91. PMID 31901249 DOI: 10.1016/J.Ajhg.2019.11.015  0.331
2019 Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, Geschwind DH. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap. Focus (American Psychiatric Publishing). 17: 66-72. PMID 32015716 DOI: 10.1176/appi.focus.17103  0.699
2019 Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 179: 750-771.e22. PMID 31626773 DOI: 10.1016/J.Cell.2019.09.021  0.721
2019 Lopez Soto EJ, Gandal MJ, Gonatopoulos-Pournatzis T, Heller EA, Luo D, Zheng S. Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic Interventions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 39: 8193-8199. PMID 31619487 DOI: 10.1523/JNEUROSCI.1149-19.2019  0.316
2019 Forsyth JK, Nachun D, Gandal MJ, Geschwind DH, Anderson AE, Coppola G, Bearden CE. Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders. Biological Psychiatry. PMID 31500805 DOI: 10.1016/J.Biopsych.2019.06.029  0.61
2019 Lee C, Kang EY, Gandal MJ, Eskin E, Geschwind DH. Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. Nature Neuroscience. 22: 1521-1532. PMID 31455884 DOI: 10.1038/S41593-019-0461-9  0.563
2019 Ruzzo EK, Pérez-Cano L, Jung JY, Wang LK, Kashef-Haghighi D, Hartl C, Singh C, Xu J, Hoekstra JN, Leventhal O, Leppä VM, Gandal MJ, Paskov K, Stockham N, Polioudakis D, et al. Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks. Cell. 178: 850-866.e26. PMID 31398340 DOI: 10.1016/J.Cell.2019.07.015  0.579
2019 Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, et al. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 177: 1600-1618.e17. PMID 31150625 DOI: 10.1016/J.Cell.2019.05.004  0.548
2019 Schork AJ, Won H, Appadurai V, Nudel R, Gandal M, Delaneau O, Revsbech Christiansen M, Hougaard DM, Bækved-Hansen M, Bybjerg-Grauholm J, Giørtz Pedersen M, Agerbo E, Bøcker Pedersen C, Neale BM, Daly MJ, et al. A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience. PMID 30692689 DOI: 10.1038/S41593-018-0320-0  0.593
2019 Forsyth J, Nachun D, Gandal M, Geschwind D, Anderson A, Coppola G, Bearden C. T55SYNAPTIC AND GENE REGULATORY MECHANISMS IN SCHIZOPHRENIA, AUTISM, AND 22Q11.2 CNV MEDIATED RISK FOR NEUROPSYCHIATRIC DISORDERS European Neuropsychopharmacology. 29: S244-S245. DOI: 10.1016/J.Euroneuro.2019.08.254  0.59
2019 Haney J, Parhami S, Ramaswami G, Alba D, Hartl C, Ou J, Parikshak N, Swarup V, Gandal M, Geschwind D. 2 Regional Variation In Transcriptional Dysregulation And Patterning In Postmortem Cerebral Cortex In Asd European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.07.143  0.703
2019 Gandal M, Zhang P, Walker R, Won H, Hadjimichael E, van Bakel H, Haney J, Jaffe A, White K, Peters M, Gerstein M, Liu C, Iakoucheva L, Pinto D, Geschwind D. SA75LARGE-SCALE TRANSCRIPTOME-WIDE CHARACTERIZATION OF ASD, SCHIZOPHRENIA, AND BIPOLAR DISORDER European Neuropsychopharmacology. 29: S1228. DOI: 10.1016/J.Euroneuro.2018.08.297  0.568
2019 Francoeur N, Gandal M, Xu X, Sarpong K, Johnson J, Sklar P, van Bakel H, Geschwind D, Pinto D. ASSESSING THE ROLE OF LONG NONCODING RNAS (LNCRNAS) IN AUTISM SPECTRUM DISORDERS European Neuropsychopharmacology. 29: S960. DOI: 10.1016/j.euroneuro.2017.08.318  0.513
2019 Gandal M, Pinto D, Iakoucheva L, Liu C, Geschwind D. 238. Transcriptome-Wide Isoform-Level Dysregulation in Schizophrenia, Autism, and Bipolar Disorder Biological Psychiatry. 85: S98-S99. DOI: 10.1016/j.biopsych.2019.03.252  0.576
2018 Fan CC, McGrath JJ, Appadurai V, Buil A, Gandal MJ, Schork AJ, Mortensen PB, Agerbo E, Geschwind SA, Geschwind D, Werge T, Thompson WK, Pedersen CB. Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia. Nature Communications. 9: 5296. PMID 30546018 DOI: 10.1038/s41467-018-07708-7  0.535
2018 Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, et al. Comprehensive functional genomic resource and integrative model for the human brain. Science (New York, N.Y.). 362. PMID 30545857 DOI: 10.1126/Science.Aat8464  0.595
2018 Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science (New York, N.Y.). 362. PMID 30545856 DOI: 10.1126/Science.Aat8127  0.635
2018 Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, ... Gandal M, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. PMID 30478444 DOI: 10.1038/S41588-018-0269-7  0.52
2018 Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, et al. Integrative network analysis reveals biological pathways associated with Williams syndrome. Journal of Child Psychology and Psychiatry, and Allied Disciplines. PMID 30362171 DOI: 10.1111/Jcpp.12999  0.729
2018 Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, de la Torre Ubieta L, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. PMID 29995847 DOI: 10.1038/S41586-018-0295-8  0.745
2018 Schwede M, Nagpal S, Gandal MJ, Parikshak NN, Mirnics K, Geschwind DH, Morrow EM. Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex. Journal of Neurodevelopmental Disorders. 10: 18. PMID 29859039 DOI: 10.1186/S11689-018-9237-X  0.74
2018 Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science (New York, N.Y.). 359: 693-697. PMID 29439242 DOI: 10.1126/Science.Aad6469  0.771
2017 Singh T, Walters JTR, Johnstone M, Curtis D, Suvisaari J, Torniainen M, Rees E, Iyegbe C, Blackwood D, McIntosh AM, Kirov G, Geschwind D, Murray RM, Di Forti M, Bramon E, ... Gandal M, et al. The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nature Genetics. PMID 28650482 DOI: 10.1038/Ng.3903  0.575
2016 Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. PMID 27919067 DOI: 10.1038/Nature20612  0.793
2016 Gandal MJ, Leppa V, Won H, Parikshak NN, Geschwind DH. The road to precision psychiatry: translating genetics into disease mechanisms. Nature Neuroscience. 19: 1397-1407. PMID 27786179 DOI: 10.1038/Nn.4409  0.742
2016 Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. PMID 27760116 DOI: 10.1038/Nature19847  0.786
2016 Gandal MJ, Geschwind DH. The Genetics-Driven Revival in Neuropsychiatric Drug Development. Biological Psychiatry. 79: 628-30. PMID 26997117 DOI: 10.1016/j.biopsych.2016.02.024  0.572
2015 Parikshak NN, Gandal MJ, Geschwind DH. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders. Nature Reviews. Genetics. 16: 441-58. PMID 26149713 DOI: 10.1038/Nrg3934  0.751
2015 Tatard-Leitman VM, Jutzeler CR, Suh J, Saunders JA, Billingslea EN, Morita S, White R, Featherstone RE, Ray R, Ortinski PI, Banerjee A, Gandal MJ, Lin R, Alexandrescu A, Liang Y, et al. Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biological Psychiatry. 77: 556-68. PMID 25156700 DOI: 10.1016/J.Biopsych.2014.06.026  0.743
2014 Port RG, Gandal MJ, Roberts TP, Siegel SJ, Carlson GC. Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology. Frontiers in Cellular Neuroscience. 8: 414. PMID 25538564 DOI: 10.3389/Fncel.2014.00414  0.639
2014 Billingslea EN, Tatard-Leitman VM, Anguiano J, Jutzeler CR, Suh J, Saunders JA, Morita S, Featherstone RE, Ortinski PI, Gandal MJ, Lin R, Liang Y, Gur RE, Carlson GC, Hahn CG, et al. Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1603-13. PMID 24525709 DOI: 10.1038/Npp.2014.7  0.765
2012 Gandal MJ, Nesbitt AM, McCurdy RM, Alter MD. Measuring the maturity of the fast-spiking interneuron transcriptional program in autism, schizophrenia, and bipolar disorder. Plos One. 7: e41215. PMID 22936973 DOI: 10.1371/journal.pone.0041215  0.448
2012 Gandal MJ, Sisti J, Klook K, Ortinski PI, Leitman V, Liang Y, Thieu T, Anderson R, Pierce RC, Jonak G, Gur RE, Carlson G, Siegel SJ. GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction. Translational Psychiatry. 2: e142. PMID 22806213 DOI: 10.1038/tp.2012.69  0.612
2012 Saunders JA, Gandal MJ, Roberts TP, Siegel SJ. NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders. Behavioural Brain Research. 234: 233-7. PMID 22771812 DOI: 10.1016/J.Bbr.2012.06.032  0.704
2012 Gandal MJ, Anderson RL, Billingslea EN, Carlson GC, Roberts TP, Siegel SJ. Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia? Genes, Brain, and Behavior. 11: 740-50. PMID 22726567 DOI: 10.1111/j.1601-183X.2012.00816.x  0.637
2012 Cao YA, Featherstone RE, Gandal MJ, Liang Y, Jutzeler C, Saunders J, Tatard-Leitman V, Chen J, Weinberger DR, Lerman C, Siegel SJ. Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density. Behavioral Neuroscience. 126: 332-43. PMID 22309446 DOI: 10.1037/A0027047  0.643
2012 Liao W, Gandal MJ, Ehrlichman RS, Siegel SJ, Carlson GC. MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder. Neurobiology of Disease. 46: 88-92. PMID 22249109 DOI: 10.1016/J.Nbd.2011.12.048  0.619
2012 Saunders JA, Gandal MJ, Siegel SJ. NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia. Neurobiology of Disease. 46: 93-100. PMID 22245663 DOI: 10.1016/J.Nbd.2011.12.049  0.66
2012 Gandal MJ, Edgar JC, Klook K, Siegel SJ. Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia. Neuropharmacology. 62: 1504-18. PMID 21349276 DOI: 10.1016/j.neuropharm.2011.02.007  0.594
2012 Roberts TPL, Gandal M, Siegel SJ, Vianney–Rodrigues P, Welsh JP. Autism spectrum disorders Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 273-302. DOI: 10.1017/CBO9780511980053.017  0.547
2011 Mehta MV, Gandal MJ, Siegel SJ. mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. Plos One. 6: e26077. PMID 22016815 DOI: 10.1371/journal.pone.0026077  0.586
2011 Carlson GC, Talbot K, Halene TB, Gandal MJ, Kazi HA, Schlosser L, Phung QH, Gur RE, Arnold SE, Siegel SJ. Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 108: E962-70. PMID 21969553 DOI: 10.1073/Pnas.1109625108  0.606
2010 Gandal MJ, Edgar JC, Ehrlichman RS, Mehta M, Roberts TP, Siegel SJ. Validating γ oscillations and delayed auditory responses as translational biomarkers of autism. Biological Psychiatry. 68: 1100-6. PMID 21130222 DOI: 10.1016/J.Biopsych.2010.09.031  0.617
2010 Amann LC, Gandal MJ, Halene TB, Ehrlichman RS, White SL, McCarren HS, Siegel SJ. Mouse behavioral endophenotypes for schizophrenia. Brain Research Bulletin. 83: 147-61. PMID 20433908 DOI: 10.1016/J.Brainresbull.2010.04.008  0.619
2010 Amann LC, Gandal MJ, Lin R, Liang Y, Siegel SJ. In vitro-in vivo correlations of scalable PLGA-risperidone implants for the treatment of schizophrenia. Pharmaceutical Research. 27: 1730-7. PMID 20422263 DOI: 10.1007/s11095-010-0152-4  0.688
2010 Lazarewicz MT, Ehrlichman RS, Maxwell CR, Gandal MJ, Finkel LH, Siegel SJ. Ketamine modulates theta and gamma oscillations. Journal of Cognitive Neuroscience. 22: 1452-64. PMID 19583475 DOI: 10.1162/Jocn.2009.21305  0.585
2009 Ehrlichman RS, Gandal MJ, Maxwell CR, Lazarewicz MT, Finkel LH, Contreras D, Turetsky BI, Siegel SJ. N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia. Neuroscience. 158: 705-12. PMID 19015010 DOI: 10.1016/J.Neuroscience.2008.10.031  0.6
2008 Gandal MJ, Ehrlichman RS, Rudnick ND, Siegel SJ. A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice. Neuroscience. 157: 95-104. PMID 18835334 DOI: 10.1016/J.Neuroscience.2008.08.060  0.551
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