Claudio Grosman - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
AChR

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Cymes GD, Grosman C. Signal transduction through Cys-loop receptors is mediated by the nonspecific bumping of closely apposed domains. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33785596 DOI: 10.1073/pnas.2021016118  1
2020 Kumar P, Wang Y, Zhang Z, Zhao Z, Cymes GD, Tajkhorshid E, Grosman C. Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31911476 DOI: 10.1073/pnas.1906823117  1
2019 Harpole TJ, Grosman C. A Crucial Role for Side-Chain Conformation in the Versatile Charge Selectivity of Cys-Loop Receptors. Biophysical Journal. PMID 31005237 DOI: 10.1016/j.bpj.2019.03.022  1
2017 Gonzalez-Gutierrez G, Wang Y, Cymes GD, Tajkhorshid E, Grosman C. Chasing the open-state structure of pentameric ligand-gated ion channels. The Journal of General Physiology. PMID 29089419 DOI: 10.1085/Jgp.201711803  1
2016 Cymes GD, Grosman C. Identifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791102 DOI: 10.1073/pnas.1608519113  1
2015 Cymes GD, Grosman C. Engineered Ionizable Side Chains. Advances in Experimental Medicine and Biology. 869: 5-23. PMID 26381938 DOI: 10.1007/978-1-4939-2845-3_2  1
2015 Gonzalez-Gutierrez G, Grosman C. The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold. The Journal of General Physiology. 146: 15-36. PMID 26078054 DOI: 10.1085/Jgp.201411333  1
2014 Harpole TJ, Grosman C. Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel. Proceedings of the National Academy of Sciences of the United States of America. 111: E3196-205. PMID 25049389 DOI: 10.1073/pnas.1408950111  1
2014 Papke D, Grosman C. The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7238-52. PMID 24849357 DOI: 10.1523/Jneurosci.5105-13.2014  1
2013 Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C. Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 110: 18716-21. PMID 24167270 DOI: 10.1073/Pnas.1313156110  1
2012 Cymes GD, Grosman C. The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors. Nature Chemical Biology. 8: 975-81. PMID 23064317 DOI: 10.1038/nchembio.1092  1
2012 Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C. Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proceedings of the National Academy of Sciences of the United States of America. 109: 6331-6. PMID 22474383 DOI: 10.1073/Pnas.1119268109  1
2011 Cymes GD, Grosman C. Estimating the pKa values of basic and acidic side chains in ion channels using electrophysiological recordings: a robust approach to an elusive problem. Proteins. 79: 3485-93. PMID 21744391 DOI: 10.1002/prot.23087  1
2011 Cymes GD, Grosman C. Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors. Nature. 474: 526-30. PMID 21602825 DOI: 10.1038/nature10015  1
2011 Papke D, Gonzalez-Gutierrez G, Grosman C. Desensitization of neurotransmitter-gated ion channels during high-frequency stimulation: a comparative study of Cys-loop, AMPA and purinergic receptors. The Journal of Physiology. 589: 1571-85. PMID 21300749 DOI: 10.1113/Jphysiol.2010.203315  1
2010 Gonzalez-Gutierrez G, Grosman C. Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states. Journal of Molecular Biology. 403: 693-705. PMID 20863833 DOI: 10.1016/J.Jmb.2010.09.026  1
2009 Elenes S, Decker M, Cymes GD, Grosman C. Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of "slow-channel syndrome" nicotinic receptor mutants. The Journal of General Physiology. 133: 151-69. PMID 19171769 DOI: 10.1085/jgp.200810089  1
2009 Elenes S, Decker M, Cymes GD, Grosman C. Response to the letter: "About a new method to measure fractional Ca2+ currents through ligand-gated ion channels" Journal of General Physiology. 134: 263-265. DOI: 10.1085/jgp.200910231  1
2008 Cymes GD, Grosman C. Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer. Nature Structural & Molecular Biology. 15: 389-96. PMID 18376414 DOI: 10.1038/nsmb.1407  1
2006 Elenes S, Ni Y, Cymes GD, Grosman C. Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor. The Journal of General Physiology. 128: 615-27. PMID 17074980 DOI: 10.1085/jgp.200609570  1
2006 Purohit Y, Grosman C. Estimating binding affinities of the nicotinic receptor for low-efficacy ligands using mixtures of agonists and two-dimensional concentration-response relationships. The Journal of General Physiology. 127: 719-35. PMID 16735756 DOI: 10.1085/Jgp.200509438  1
2006 Purohit Y, Grosman C. Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities. The Journal of General Physiology. 127: 703-17. PMID 16735755 DOI: 10.1085/Jgp.200509437  1
2005 Cymes GD, Ni Y, Grosman C. Probing ion-channel pores one proton at a time. Nature. 438: 975-80. PMID 16355215 DOI: 10.1038/nature04293  1
2003 Grosman C. Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels. Biochemistry. 42: 14977-87. PMID 14674774 DOI: 10.1021/bi0354334  1
2002 Grosman C. Linear free-energy relationships and the dynamics of gating in the acetylcholine receptor channel. Journal of Biological Physics. 28: 267-77. PMID 23345774 DOI: 10.1023/A:1019935832427  1
2002 Cymes GD, Grosman C, Auerbach A. Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry. 41: 5548-55. PMID 11969415 DOI: 10.1021/bi011864f  1
2001 Grosman C, Auerbach A. The dissociation of acetylcholine from open nicotinic receptor channels. Proceedings of the National Academy of Sciences of the United States of America. 98: 14102-7. PMID 11717464 DOI: 10.1073/pnas.251402498  1
2001 Pérez-Serrano J, Grosman C, Urrea-París MA, Denegri G, Casado N, Rodríguez-Caabeiro F. Depolarization of the tegument precedes morphological alterations in Echinococcus granulosus protoscoleces incubated with ivermectin. Parasitology Research. 87: 804-7. PMID 11688885 DOI: 10.1007/s004360100435  1
2000 Grosman C, Salamone FN, Sine SM, Auerbach A. The extracellular linker of muscle acetylcholine receptor channels is a gating control element. The Journal of General Physiology. 116: 327-40. PMID 10962011 DOI: 10.1085/Jgp.116.3.327  1
2000 Grosman C, Auerbach A. Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist. The Journal of General Physiology. 115: 637-51. PMID 10779320 DOI: 10.1085/jgp.115.5.637  1
2000 Grosman C, Auerbach A. Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants. The Journal of General Physiology. 115: 621-35. PMID 10779319 DOI: 10.1085/jgp.115.5.621  1
2000 Grosman C, Reisin IL. Single-channel characterization of a nonselective cation channel from human placental microvillus membranes. Large conductance, multiplicity of conductance states, and inhibition by lanthanides. The Journal of Membrane Biology. 174: 59-70. PMID 10741433 DOI: 10.1007/S002320001032  1
2000 Grosman C, Zhou M, Auerbach A. Mapping the conformational wave of acetylcholine receptor channel gating. Nature. 403: 773-6. PMID 10693806 DOI: 10.1038/35001586  1
1998 Cantiello HF, Jackson GR, Grosman CF, Prat AG, Borkan SC, Wang Y, Reisin IL, O'Riordan CR, Ausiello DA. Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator. The American Journal of Physiology. 274: C799-809. PMID 9530112 DOI: 10.1152/Ajpcell.1998.274.3.C799  1
1997 Grosman C, Reisin IL. Interconverting gating modes of a nonselective cation channel from the tapeworm Echinococcus granulosus reconstituted on planar lipid bilayers. The Journal of Membrane Biology. 158: 87-94. PMID 9211724 DOI: 10.1007/S002329900246  1
1997 Grosman C, Mariano MI, Bozzini JP, Reisin IL. Properties of two multisubstate Cl- channels from human syncytiotrophoblast reconstituted on planar lipid bilayers. The Journal of Membrane Biology. 157: 83-95. PMID 9141361 DOI: 10.1007/S002329900218  1
1996 Cymes GD, Grosman C, Delfino JM, Wolfenstein-Todel C. Detection and characterization of an ovine placental lactogen stable intermediate in the urea-induced unfolding process. Protein Science : a Publication of the Protein Society. 5: 2074-9. PMID 8897607 DOI: 10.1002/pro.5560051013  1
1995 Grosman C, Reisin IL. Echinococcus granulosus: partial characterization of the conductive properties of two cation channels from protoscoleces of the ovine strain, reconstituted on planar lipid bilayers. Experimental Parasitology. 81: 546-55. PMID 8542996 DOI: 10.1006/Expr.1995.1148  1
1992 Bari S, Frydman RB, Grosman C, Frydman B. The interplay between basicity, conformation, and enzymatic reduction in biliverdins. Biochemical and Biophysical Research Communications. 188: 48-56. PMID 1417867 DOI: 10.1016/0006-291X(92)92348-2  1
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