| Year |
Citation |
Score |
| 2024 |
Chaban A, Minakhin L, Goldobina E, Bae B, Hao Y, Borukhov S, Putzeys L, Boon M, Kabinger F, Lavigne R, Makarova KS, Koonin EV, Nair SK, Tagami S, Severinov K, et al. Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail. Nature Communications. 15: 317. PMID 38182597 DOI: 10.1038/s41467-023-44630-z |
0.463 |
|
| 2023 |
Pei ZF, Zhu L, Nair SK. Core-dependent post-translational modifications guide the biosynthesis of a new class of hypermodified peptides. Nature Communications. 14: 7734. PMID 38007494 DOI: 10.1038/s41467-023-43604-5 |
0.36 |
|
| 2023 |
Hernandez Garcia A, Nair SK. Structure and Function of a Class III Metal-Independent Lanthipeptide Synthetase. Acs Central Science. 9: 1944-1956. PMID 37901177 DOI: 10.1021/acscentsci.3c00484 |
0.322 |
|
| 2023 |
Ongpipattanakul C, Liu S, Luo Y, Nair SK, van der Donk WA. The mechanism of thia-Michael addition catalyzed by LanC enzymes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217523120. PMID 36634136 DOI: 10.1073/pnas.2217523120 |
0.429 |
|
| 2022 |
Park R, Ongpipattanakul C, Nair SK, Bowers AA, Kuhlman B. Designer installation of a substrate recruitment domain to tailor enzyme specificity. Nature Chemical Biology. PMID 36509904 DOI: 10.1038/s41589-022-01206-0 |
0.366 |
|
| 2022 |
Rice AJ, Pelton JM, Kramer NJ, Catlin DS, Nair SK, Pogorelov TV, Mitchell DA, Bowers AA. Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. Journal of the American Chemical Society. PMID 36351243 DOI: 10.1021/jacs.2c07377 |
0.411 |
|
| 2022 |
Zheng Y, Nair SK. YcaO-mediated ATP-dependent peptidase activity in ribosomal peptide biosynthesis. Nature Chemical Biology. PMID 36280794 DOI: 10.1038/s41589-022-01141-0 |
0.382 |
|
| 2022 |
Pei ZF, Zhu L, Sarksian R, van der Donk WA, Nair SK. Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product. Journal of the American Chemical Society. 144: 17549-17557. PMID 36107785 DOI: 10.1021/jacs.2c06808 |
0.334 |
|
| 2022 |
Zheng Y, Cong Y, Schmidt EW, Nair SK. Catalysts for the Enzymatic Lipidation of Peptides. Accounts of Chemical Research. PMID 35442036 DOI: 10.1021/acs.accounts.2c00108 |
0.406 |
|
| 2022 |
Gu W, Zheng Y, Pogorelov T, Nair SK, Schmidt EW. Control of Nucleophile Chemoselectivity in Cyanobactin YcaO Heterocyclases PatD and TruD. Acs Chemical Biology. PMID 35420020 DOI: 10.1021/acschembio.2c00147 |
0.318 |
|
| 2022 |
Cogan DP, Bhushan A, Reyes R, Zhu L, Piel J, Nair SK. Structure and mechanism for iterative amide -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proceedings of the National Academy of Sciences of the United States of America. 119: e2116578119. PMID 35316135 DOI: 10.1073/pnas.2116578119 |
0.793 |
|
| 2021 |
Fujinami D, Garcia de Gonzalo CV, Biswas S, Hao Y, Wang H, Garg N, Lukk T, Nair SK, van der Donk WA. Structural and mechanistic investigations of protein S-glycosyltransferases. Cell Chemical Biology. PMID 34283964 DOI: 10.1016/j.chembiol.2021.06.009 |
0.811 |
|
| 2021 |
Grigoreva A, Andreeva J, Bikmetov D, Rusanova A, Serebryakova M, Garcia AH, Slonova D, Nair SK, Lippens G, Severinov K, Dubiley S. Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from sv. . Iscience. 24: 102480. PMID 34113822 DOI: 10.1016/j.isci.2021.102480 |
0.347 |
|
| 2021 |
Simon MA, Ongpipattanakul C, Nair SK, van der Donk WA. Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34074759 DOI: 10.1073/pnas.2019863118 |
0.412 |
|
| 2021 |
Lai KY, Galan SRG, Zeng Y, Zhou TH, He C, Raj R, Riedl J, Liu S, Chooi KP, Garg N, Zeng M, Jones LH, Hutchings GJ, Mohammed S, Nair SK, et al. LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome. Cell. PMID 33932340 DOI: 10.1016/j.cell.2021.04.001 |
0.376 |
|
| 2021 |
Griffin SL, Chekan JR, Lira JM, Robinson AE, Yerkes CN, Siehl DL, Wright TR, Nair SK, Cicchillo RM. Characterization of a Glyphosate-Tolerant Enzyme from : A Distinct Class of 5-Enolpyruvylshikimate-3-phosphate Synthases. Journal of Agricultural and Food Chemistry. PMID 33826316 DOI: 10.1021/acs.jafc.1c00439 |
0.743 |
|
| 2021 |
Liu A, Si Y, Dong SH, Mahanta N, Penkala HN, Nair SK, Mitchell DA. Functional elucidation of TfuA in peptide backbone thioamidation. Nature Chemical Biology. PMID 33707784 DOI: 10.1038/s41589-021-00771-0 |
0.802 |
|
| 2020 |
Cogan DP, Ly J, Nair SK. Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. Acs Chemical Biology. PMID 33017142 DOI: 10.1021/acschembio.0c00579 |
0.834 |
|
| 2020 |
Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, ... ... Nair SK, et al. New developments in RiPP discovery, enzymology and engineering. Natural Product Reports. PMID 32935693 DOI: 10.1039/D0Np00027B |
0.36 |
|
| 2020 |
Bogart JW, Kramer NJ, Turlik A, Bleich RM, Catlin DS, Schroeder FC, Nair SK, Williamson RT, Houk KN, Bowers AA. Interception of the "Bycroft-Gowland" intermediate in the enzymatic macrocyclization of thiopeptides. Journal of the American Chemical Society. PMID 32609512 DOI: 10.1021/Jacs.0C05639 |
0.439 |
|
| 2020 |
Kapoor I, Olivares P, Nair SK. Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones. Elife. 9. PMID 32510324 DOI: 10.7554/eLife.57824 |
0.798 |
|
| 2020 |
Dong SH, Nhu-Lam M, Nagarajan R, Nair SK. Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities. Acs Chemical Biology. PMID 32356962 DOI: 10.1021/Acschembio.0C00142 |
0.753 |
|
| 2020 |
Nayak DD, Liu A, Agrawal N, Rodriguez-Carerro R, Dong SH, Mitchell DA, Nair SK, Metcalf WW. Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans. Plos Biology. 18: e3000507. PMID 32092071 DOI: 10.1371/Journal.Pbio.3000507 |
0.755 |
|
| 2019 |
Chekan JR, Ongpipattanakul C, Nair SK. Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 116: 24049-24055. PMID 31719203 DOI: 10.1073/pnas.1908364116 |
0.736 |
|
| 2019 |
Huo L, Zhao X, Acedo JZ, Estrada P, Nair SK, van der Donk WA. Characterization of a dehydratase and methyltransferase in the biosynthesis of a ribosomally-synthesized and post-translationally modified peptide in Lachnospiraceae. Chembiochem : a European Journal of Chemical Biology. PMID 31532570 DOI: 10.1002/Cbic.201900483 |
0.813 |
|
| 2019 |
Bothwell IR, Cogan DP, Kim T, Reinhardt CJ, van der Donk WA, Nair SK. Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics. Proceedings of the National Academy of Sciences of the United States of America. PMID 31409709 DOI: 10.1073/pnas.1905240116 |
0.822 |
|
| 2019 |
Chekan JR, Ongpipattanakul C, Wright TR, Zhang B, Bollinger JM, Rajakovich LJ, Krebs C, Cicchillo RM, Nair SK. Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants. Proceedings of the National Academy of Sciences of the United States of America. PMID 31209034 DOI: 10.1073/Pnas.1900711116 |
0.757 |
|
| 2019 |
Dong SH, Liu A, Mahanta N, Mitchell DA, Nair SK. Mechanistic Basis for Ribosomal Peptide Backbone Modifications. Acs Central Science. 5: 842-851. PMID 31139720 DOI: 10.1021/Acscentsci.9B00124 |
0.782 |
|
| 2019 |
Zukher I, Pavlov M, Tsibulskaya D, Kulikovsky A, Zyubko T, Bikmetov D, Serebryakova M, Nair SK, Ehrenberg M, Dubiley S, Severinov K. Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor. Mbio. 10. PMID 31040244 DOI: 10.1128/mBio.00768-19 |
0.3 |
|
| 2019 |
Dong SH, Kulikovsky A, Zukher I, Estrada P, Dubiley S, Severinov K, Nair SK. Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the -formyl of the peptide precursor. Chemical Science. 10: 2391-2395. PMID 30881667 DOI: 10.1039/c8sc03173h |
0.813 |
|
| 2019 |
Petronikolou N, Ortega MA, Borisova SA, Nair SK, Metcalf WW. Molecular basis of Bacillus subtilis ATCC6633 self-resistance to the phosphono-oligopeptide antibiotic rhizocticin. Acs Chemical Biology. PMID 30830751 DOI: 10.1021/Acschembio.9B00030 |
0.82 |
|
| 2019 |
Nguyen K, DeSieno MA, Bae B, Johannes TW, Cobb RE, Zhao H, Nair SK. Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098. Organic & Biomolecular Chemistry. PMID 30681110 DOI: 10.1039/C8Ob02840K |
0.816 |
|
| 2019 |
Bobeica SC, Dong S, Huo L, Mazo N, McLaughlin MIH, Jiménez-Osés G, Nair SK, van der Donk WA. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. Elife. 8. PMID 30638446 DOI: 10.7554/Elife.42305 |
0.747 |
|
| 2018 |
Petronikolou N, Nair SK. Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters. Acs Catalysis. 8: 6334-6344. PMID 31559109 DOI: 10.1021/acscatal.8b00787 |
0.83 |
|
| 2018 |
Ongpipattanakul C, Nair SK. Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis. Acs Chemical Biology. 13: 2989-2999. PMID 30204409 DOI: 10.1021/acschembio.8b00668 |
0.302 |
|
| 2018 |
An L, Cogan DP, Navo CD, Jiménez-Osés G, Nair SK, van der Donk WA. Substrate-assisted enzymatic formation of lysinoalanine in duramycin. Nature Chemical Biology. PMID 30177849 DOI: 10.1038/s41589-018-0122-4 |
0.827 |
|
| 2018 |
Kapoor I, Nair SK. Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin. Biochemistry. 57: 5282-5288. PMID 30125480 DOI: 10.1021/acs.biochem.8b00576 |
0.816 |
|
| 2018 |
O'Reilly MC, Dong SH, Rossi FM, Karlen KM, Kumar RS, Nair SK, Blackwell HE. Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chemical Biology. PMID 30033130 DOI: 10.1016/J.Chembiol.2018.06.007 |
0.706 |
|
| 2018 |
Estrada P, Morita M, Hao Y, Schmidt EW, Nair S. A Single Amino Acid Switch Alters the Isoprene Donor Specificity in RiPP Prenyltransferases. Journal of the American Chemical Society. PMID 29924593 DOI: 10.1021/jacs.8b05187 |
0.816 |
|
| 2018 |
Cogan DP, Baraquet C, Harwood CS, Nair SK. Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism in Rhodopseudomonas palustris. The Journal of Biological Chemistry. PMID 29794028 DOI: 10.1074/Jbc.Ra118.003561 |
0.796 |
|
| 2018 |
Gu W, Dong SH, Sarkar S, Nair SK, Schmidt EW. The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis. Methods in Enzymology. 604: 113-163. PMID 29779651 DOI: 10.1016/Bs.Mie.2018.03.002 |
0.778 |
|
| 2018 |
Morita M, Hao Y, Jokela J, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW. Posttranslational Tyrosine Geranylation in Cyanobactin Biosynthesis. Journal of the American Chemical Society. PMID 29701961 DOI: 10.1021/Jacs.8B03137 |
0.6 |
|
| 2018 |
Mahanta N, Liu A, Dong S, Nair SK, Mitchell DA. Enzymatic reconstitution of ribosomal peptide backbone thioamidation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507203 DOI: 10.1073/Pnas.1722324115 |
0.415 |
|
| 2018 |
Petronikolou N, Hollatz A, Schuler MA, Nair SK. Loganic Acid Methyltransferase: Insights into the specificity of methylation on an iridoid glycoside. Chembiochem : a European Journal of Chemical Biology. PMID 29399933 DOI: 10.1002/cbic.201700679 |
0.797 |
|
| 2018 |
Estrada P, Morita M, Hao Y, Schmidt EW, Nair SK. A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases Journal of the American Chemical Society. 140: 8124-8127. DOI: 10.2210/Pdb6Pgm/Pdb |
0.335 |
|
| 2018 |
An L, Cogan DP, Navo CD, Jimenez-Oses G, Nair SK, Donk WAvd. Substrate-assisted enzymatic formation of lysinoalanine in duramycin. Nature Chemical Biology. 14: 928-933. DOI: 10.2210/Pdb6C0G/Pdb |
0.397 |
|
| 2017 |
Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK. Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158402 DOI: 10.1073/Pnas.1716035114 |
0.843 |
|
| 2017 |
Dong SH, Frane ND, Christensen QH, Greenberg EP, Nagarajan R, Nair SK. Molecular basis for the substrate specificity of quorum signal synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784791 DOI: 10.1073/Pnas.1705400114 |
0.766 |
|
| 2017 |
Chekan JR, Estrada P, Covello PS, Nair SK. Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584123 DOI: 10.1073/pnas.1620499114 |
0.825 |
|
| 2017 |
Estrada P, Manandhar M, Dong SH, Deveryshetty J, Agarwal V, Cronan JE, Nair SK. The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nature Chemical Biology. PMID 28414711 DOI: 10.1038/Nchembio.2359 |
0.811 |
|
| 2017 |
Sardar D, Hao Y, Lin Z, Morita M, Nair SK, Schmidt EW. Enzymatic N- and C-protection in cyanobactin RiPP natural products. Journal of the American Chemical Society. PMID 28195477 DOI: 10.1021/Jacs.6B12872 |
0.551 |
|
| 2017 |
Repka LM, Chekan JR, Nair SK, van der Donk WA. Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chemical Reviews. PMID 28135077 DOI: 10.1021/acs.chemrev.6b00591 |
0.758 |
|
| 2016 |
Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli S, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA. Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis. Acs Chemical Biology. PMID 28032983 DOI: 10.1021/Acschembio.6B01031 |
0.84 |
|
| 2016 |
Chekan JR, Koos JD, Zong C, Maksimov MO, Link AJ, Nair SK. Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates. Journal of the American Chemical Society. 138: 16452-16458. PMID 27998080 DOI: 10.1021/Jacs.6B10389 |
0.744 |
|
| 2016 |
Olivares P, Ulrich EC, Chekan JR, van der Donk WA, Nair SK. Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads. Acs Chemical Biology. PMID 27977135 DOI: 10.1021/acschembio.6b00939 |
0.748 |
|
| 2016 |
Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE, Schmidt EW, Nair SK. Molecular basis for the broad substrate selectivity of a peptide prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872314 DOI: 10.1073/Pnas.1609869113 |
0.775 |
|
| 2016 |
Ortega MA, Hao Y, Walker MC, Donadio S, Sosio M, Nair SK, van der Donk WA. Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis. Cell Chemical Biology. PMID 26877024 DOI: 10.1016/J.Chembiol.2015.11.017 |
0.6 |
|
| 2016 |
Chekan JR, Cogan DP, Nair SK. Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides. Medchemcomm. 7: 28-36. PMID 26811741 DOI: 10.1039/C5MD00351B |
0.78 |
|
| 2016 |
Chekan JR, Cogan DP, Nair SK. Molecular basis for resistance against phosphonate antibiotics and herbicides Medchemcomm. 7: 28-36. DOI: 10.1039/c5md00351b |
0.653 |
|
| 2015 |
Tang W, Dong SH, Repka LM, He C, Nair SK, van der Donk WA. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chemical Science. 6: 6270-6279. PMID 30090246 DOI: 10.1039/C5Sc02329G |
0.753 |
|
| 2015 |
Petronikolou N, Nair SK. Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel. Chemistry & Biology. PMID 26526103 DOI: 10.1016/j.chembiol.2015.09.011 |
0.805 |
|
| 2015 |
Li Z, Nair SK. Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase. Structure (London, England : 1993). PMID 26412334 DOI: 10.1016/j.str.2015.08.012 |
0.487 |
|
| 2015 |
Dong SH, Tang W, Lukk T, Yu Y, Nair SK, van der Donk WA. The enterrococcal cytolysin synthetase has an unanticipated lipid kinase fold. Elife. 4. PMID 26226635 DOI: 10.7554/Elife.07607 |
0.82 |
|
| 2015 |
Garg A, Lukk T, Kumar V, Choi JY, Augagneur Y, Voelker DR, Nair S, Ben Mamoun C. Structure, function and inhibition of the phosphoethanolamine methyltransferases of the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Scientific Reports. 5: 9064. PMID 25761669 DOI: 10.1038/Srep09064 |
0.71 |
|
| 2015 |
Peck SC, Chekan JR, Ulrich EC, Nair SK, van der Donk WA. A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase. Journal of the American Chemical Society. 137: 3217-20. PMID 25699631 DOI: 10.1021/Jacs.5B00282 |
0.721 |
|
| 2015 |
Hao Y, Blair PM, Sharma A, Mitchell DA, Nair SK. Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin. Acs Chemical Biology. 10: 1209-16. PMID 25635336 DOI: 10.1021/Cb501042A |
0.625 |
|
| 2015 |
Cobb RE, Bae B, Li Z, DeSieno MA, Nair SK, Zhao H. Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor. Chemical Communications (Cambridge, England). 51: 2526-8. PMID 25567100 DOI: 10.1039/C4Cc09181G |
0.762 |
|
| 2015 |
Ortega MA, Hao Y, Zhang Q, Walker MC, van der Donk WA, Nair SK. Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature. 517: 509-12. PMID 25363770 DOI: 10.1038/Nature13888 |
0.612 |
|
| 2015 |
Dong S, Tang W, Lukk T, Yu Y, Nair SK, Donk WAvd. Author response: The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold Elife. DOI: 10.7554/Elife.07607.027 |
0.657 |
|
| 2014 |
van der Donk WA, Nair SK. Structure and mechanism of lanthipeptide biosynthetic enzymes. Current Opinion in Structural Biology. 29: 58-66. PMID 25460269 DOI: 10.1016/j.sbi.2014.09.006 |
0.429 |
|
| 2014 |
Chekan JR, Kwon IH, Agarwal V, Dodd D, Revindran V, Mackie RI, Cann I, Nair SK. Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17. The Journal of Biological Chemistry. 289: 34965-77. PMID 25342756 DOI: 10.1074/Jbc.M114.579904 |
0.826 |
|
| 2014 |
Zhang M, Chekan JR, Dodd D, Hong PY, Radlinski L, Revindran V, Nair SK, Mackie RI, Cann I. Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes. Proceedings of the National Academy of Sciences of the United States of America. 111: E3708-17. PMID 25136124 DOI: 10.1073/Pnas.1406156111 |
0.752 |
|
| 2014 |
Dunbar KL, Chekan JR, Cox CL, Burkhart BJ, Nair SK, Mitchell DA. Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis. Nature Chemical Biology. 10: 823-9. PMID 25129028 DOI: 10.1038/Nchembio.1608 |
0.738 |
|
| 2014 |
Kazakov T, Kuznedelov K, Semenova E, Mukhamedyarov D, Datsenko KA, Metlitskaya A, Vondenhoff GH, Tikhonov A, Agarwal V, Nair S, Van Aerschot A, Severinov K. The RimL transacetylase provides resistance to translation inhibitor microcin C. Journal of Bacteriology. 196: 3377-85. PMID 25002546 DOI: 10.1128/JB.01584-14 |
0.654 |
|
| 2014 |
Majumdar S, Lukk T, Solbiati JO, Bauer S, Nair SK, Cronan JE, Gerlt JA. Roles of small laccases from Streptomyces in lignin degradation. Biochemistry. 53: 4047-58. PMID 24870309 DOI: 10.1021/Bi500285T |
0.777 |
|
| 2014 |
Ortega MA, Velásquez JE, Garg N, Zhang Q, Joyce RE, Nair SK, van der Donk WA. Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO. Acs Chemical Biology. 9: 1718-25. PMID 24866416 DOI: 10.1021/Cb5002526 |
0.327 |
|
| 2014 |
Hung JE, Fogle EJ, Garg N, Chekan JR, Nair SK, van der Donk WA. Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase. Plos One. 9: e87134. PMID 24498026 DOI: 10.1371/Journal.Pone.0087134 |
0.73 |
|
| 2014 |
Park D, Jagtap S, Nair SK. Structure of a PL17 family alginate lyase demonstrates functional similarities among exotype depolymerases. The Journal of Biological Chemistry. 289: 8645-55. PMID 24478312 DOI: 10.1074/jbc.M113.531111 |
0.611 |
|
| 2014 |
Agarwal V, Peck SC, Chen JH, Borisova SA, Chekan JR, van der Donk WA, Nair SK. Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation. Chemistry & Biology. 21: 125-35. PMID 24361046 DOI: 10.1016/J.Chembiol.2013.11.006 |
0.839 |
|
| 2013 |
Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C. Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 110: 18716-21. PMID 24167270 DOI: 10.1073/Pnas.1313156110 |
0.293 |
|
| 2013 |
Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA. Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12954-9. PMID 23878226 DOI: 10.1073/Pnas.1306101110 |
0.792 |
|
| 2013 |
Perry SL, Guha S, Pawate AS, Bhaskarla A, Agarwal V, Nair SK, Kenis PJ. A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction. Lab On a Chip. 13: 3183-7. PMID 23828485 DOI: 10.1039/C3Lc50276G |
0.646 |
|
| 2013 |
Kelley SL, Lukk T, Nair SK, Tapping RI. The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. Journal of Immunology (Baltimore, Md. : 1950). 190: 1304-11. PMID 23264655 DOI: 10.4049/Jimmunol.1202446 |
0.71 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Nair SK, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F |
0.496 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Nair SK, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A |
0.489 |
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| 2012 |
Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK. Structures of cyanobactin maturation enzymes define a family of transamidating proteases. Chemistry & Biology. 19: 1411-22. PMID 23177196 DOI: 10.1016/J.Chembiol.2012.09.012 |
0.71 |
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| 2012 |
Agarwal V, Lin S, Lukk T, Nair SK, Cronan JE. Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 17406-11. PMID 23045647 DOI: 10.1073/Pnas.1207028109 |
0.827 |
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| 2012 |
Han Y, Agarwal V, Dodd D, Kim J, Bae B, Mackie RI, Nair SK, Cann IK. Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus. The Journal of Biological Chemistry. 287: 34946-60. PMID 22918832 DOI: 10.1074/Jbc.M112.391532 |
0.832 |
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| 2012 |
Li Z, Nair SK. Quorum sensing: how bacteria can coordinate activity and synchronize their response to external signals? Protein Science : a Publication of the Protein Society. 21: 1403-17. PMID 22825856 DOI: 10.1002/pro.2132 |
0.381 |
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| 2012 |
Li Z, Chen JH, Hao Y, Nair SK. Structures of the PelD cyclic diguanylate effector involved in pellicle formation in Pseudomonas aeruginosa PAO1. The Journal of Biological Chemistry. 287: 30191-204. PMID 22810222 DOI: 10.1074/jbc.M112.378273 |
0.592 |
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| 2012 |
Liu YL, Guerra F, Wang K, Wang W, Li J, Huang C, Zhu W, Houlihan K, Li Z, Zhang Y, Nair SK, Oldfield E. Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins. Proceedings of the National Academy of Sciences of the United States of America. 109: 8558-63. PMID 22586085 DOI: 10.1073/Pnas.1121107109 |
0.324 |
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| 2012 |
Zou Y, Zhang H, Brunzelle JS, Johannes TW, Woodyer R, Hung JE, Nair N, Van Der Donk WA, Zhao H, Nair SK. Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration Biochemistry. 51: 4263-4270. PMID 22564171 DOI: 10.1021/Bi2016926 |
0.829 |
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| 2012 |
Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C. Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proceedings of the National Academy of Sciences of the United States of America. 109: 6331-6. PMID 22474383 DOI: 10.1073/Pnas.1119268109 |
0.784 |
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| 2012 |
Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, et al. Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 109: 4122-7. PMID 22392983 DOI: 10.1073/Pnas.1112081109 |
0.798 |
|
| 2012 |
Agarwal V, Tikhonov A, Metlitskaya A, Severinov K, Nair SK. Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7. Proceedings of the National Academy of Sciences of the United States of America. 109: 4425-30. PMID 22388748 DOI: 10.1073/pnas.1114224109 |
0.738 |
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| 2011 |
Agarwal V, Borisova SA, Metcalf WW, van der Donk WA, Nair SK. Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chemistry & Biology. 18: 1230-40. PMID 22035792 DOI: 10.1016/J.Chembiol.2011.07.019 |
0.713 |
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| 2011 |
Bae B, Cobb RE, DeSieno MA, Zhao H, Nair SK. New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF. The Journal of Biological Chemistry. 286: 36132-41. PMID 21865168 DOI: 10.1074/Jbc.M111.263533 |
0.81 |
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| 2011 |
Agarwal V, Metlitskaya A, Severinov K, Nair SK. Structural basis for microcin C7 inactivation by the MccE acetyltransferase. The Journal of Biological Chemistry. 286: 21295-303. PMID 21507941 DOI: 10.1074/jbc.M111.226282 |
0.715 |
|
| 2011 |
Li Z, Rupasinghe SG, Schuler MA, Nair SK. Crystal structure of a phenol-coupling P450 monooxygenase involved in teicoplanin biosynthesis. Proteins. 79: 1728-38. PMID 21445994 DOI: 10.1002/Prot.22996 |
0.471 |
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| 2011 |
Yoshida S, Park DS, Bae B, Mackie R, Cann IK, Nair SK. Structural and functional analyses of a glycoside hydrolase family 5 enzyme with an unexpected β-fucosidase activity. Biochemistry. 50: 3369-75. PMID 21410228 DOI: 10.1021/Bi200222U |
0.819 |
|
| 2011 |
Nair SK, Van Der Donk WA. Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin Archives of Biochemistry and Biophysics. 505: 13-21. PMID 20854789 DOI: 10.1016/j.abb.2010.09.012 |
0.323 |
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| 2010 |
McIntosh JA, Robertson CR, Agarwal V, Nair SK, Bulaj GW, Schmidt EW. Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst. Journal of the American Chemical Society. 132: 15499-501. PMID 20961047 DOI: 10.1021/Ja1067806 |
0.653 |
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| 2010 |
Lee JH, Bae B, Kuemin M, Circello BT, Metcalf WW, Nair SK, Van Der Donk WA. Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 107: 17557-17562. PMID 20876132 DOI: 10.1073/Pnas.1006848107 |
0.818 |
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| 2010 |
Su X, Agarwal V, Dodd D, Bae B, Mackie RI, Nair SK, Cann IK. Mutational insights into the roles of amino acid residues in ligand binding for two closely related family 16 carbohydrate binding modules. The Journal of Biological Chemistry. 285: 34665-76. PMID 20739280 DOI: 10.1074/Jbc.M110.168302 |
0.81 |
|
| 2010 |
Bae B, Sullivan RP, Zhao H, Nair SK. Structure and engineering of L-arabinitol 4-dehydrogenase from Neurospora crassa. Journal of Molecular Biology. 402: 230-40. PMID 20655316 DOI: 10.1016/J.Jmb.2010.07.033 |
0.779 |
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| 2010 |
Cann I, Dodd D, Kiyonari S, Moon YH, Schroeder C, Nair S, Mackie R. The Genus Prevotella, A Resource of Enzymes for Hemicellulose Degradation Biophysical Journal. 98: 210a. DOI: 10.1016/J.Bpj.2009.12.1130 |
0.329 |
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| 2009 |
Zou Y, Nair SK. Molecular Basis for the Recognition of Structurally Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum-Sensing Signaling Receptor Chemistry and Biology. 16: 961-970. PMID 19778724 DOI: 10.1016/j.chembiol.2009.09.001 |
0.798 |
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| 2009 |
Cicchillo RM, Zhang H, Blodgett JAV, Whitteck JT, Li G, Nair SK, Van Der Donk WA, Metcalf WW. An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis Nature. 459: 871-874. PMID 19516340 DOI: 10.1038/Nature07972 |
0.693 |
|
| 2009 |
Bae B, Chen YH, Costa A, Onesti S, Brunzelle JS, Lin Y, Cann IK, Nair SK. Insights into the architecture of the replicative helicase from the structure of an archaeal MCM homolog. Structure (London, England : 1993). 17: 211-22. PMID 19217392 DOI: 10.1016/J.Str.2008.11.010 |
0.791 |
|
| 2008 |
Rubin-Pitel SB, Zhang H, Vu T, Brunzelle JS, Zhao H, Nair SK. Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa. Chemistry & Biology. 15: 1079-90. PMID 18940668 DOI: 10.1016/J.Chembiol.2008.08.011 |
0.737 |
|
| 2008 |
Zou Y, Brunzelle JS, Nair SK. Crystal Structures of Lipoglycopeptide Antibiotic Deacetylases: Implications for the Biosynthesis of A40926 and Teicoplanin Chemistry and Biology. 15: 533-545. PMID 18559264 DOI: 10.1016/j.chembiol.2008.05.009 |
0.812 |
|
| 2008 |
Choi YS, Zhang H, Brunzelle JS, Nair SK, Zhao H. In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 6858-63. PMID 18458342 DOI: 10.1073/Pnas.0712073105 |
0.718 |
|
| 2008 |
Bae B, Ohene-Adjei S, Kocherginskaya S, Mackie RI, Spies MA, Cann IK, Nair SK. Molecular basis for the selectivity and specificity of ligand recognition by the family 16 carbohydrate-binding modules from Thermoanaerobacterium polysaccharolyticum ManA. The Journal of Biological Chemistry. 283: 12415-25. PMID 18025086 DOI: 10.1074/Jbc.M706513200 |
0.791 |
|
| 2007 |
Zou Y, Li C, Brunzelle JS, Nair SK. Molecular basis for substrate selectivity and specificity by an LPS biosynthetic enzyme. Biochemistry. 46: 4294-304. PMID 17371001 DOI: 10.1021/bi061056u |
0.829 |
|
| 2007 |
Kemp M, Bae B, Yu JP, Ghosh M, Leffak M, Nair SK. Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B. The Journal of Biological Chemistry. 282: 10441-8. PMID 17264083 DOI: 10.1074/Jbc.M609632200 |
0.781 |
|
| 2006 |
Lasker MV, Nair SK. Intracellular TLR signaling: a structural perspective on human disease. Journal of Immunology (Baltimore, Md. : 1950). 177: 11-6. PMID 16785490 DOI: 10.4049/jimmunol.177.1.11 |
0.773 |
|
| 2006 |
Lasker MV, Kuruvilla SM, Gajjar MM, Kapoor A, Nair SK. Metal ion-mediated reduction in surface entropy improves diffraction quality of crystals of the IRAK-4 death domain. Journal of Biomolecular Techniques : Jbt. 17: 114-21. PMID 16741238 |
0.795 |
|
| 2006 |
Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK. Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (New York, N.Y.). 311: 1464-7. PMID 16527981 DOI: 10.1126/Science.1121422 |
0.423 |
|
| 2005 |
Lasker MV, Gajjar MM, Nair SK. Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. Journal of Immunology (Baltimore, Md. : 1950). 175: 4175-9. PMID 16177054 DOI: 10.4049/jimmunol.175.7.4175 |
0.794 |
|
| 1996 |
Stams T, Nair SK, Okuyama T, Waheed A, Sly WS, Christianson DW. Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 93: 13589-94. PMID 8942978 DOI: 10.1073/Pnas.93.24.13589 |
0.563 |
|
| 1996 |
Nair SK, Elbaum D, Christianson DW. Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor. The Journal of Biological Chemistry. 271: 1003-7. PMID 8557623 DOI: 10.1074/Jbc.271.2.1003 |
0.52 |
|
| 1996 |
Elbaum D, Nair SK, Patchan MW, Thompson RB, Christianson DW. Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor Journal of the American Chemical Society. 118: 8381-8387. DOI: 10.1021/Ja954102E |
0.439 |
|
| 1995 |
Ippolito JA, Nair SK, Alexander RS, Kiefer LL, Fierke CA, Christianson DW. Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site. Protein Engineering. 8: 975-80. PMID 8771178 DOI: 10.1093/Protein/8.10.975 |
0.509 |
|
| 1995 |
Nair SK, Krebs JF, Christianson DW, Fierke CA. Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. Biochemistry. 34: 3981-9. PMID 7696263 DOI: 10.1021/Bi00012A016 |
0.559 |
|
| 1994 |
Nair SK, Ludwig PA, Christianson DW. Two-site binding of phenol in the active site of human carbonic anhydrase II: Structural implications for substrate association Journal of the American Chemical Society. 116: 3659-3660. DOI: 10.1021/Ja00087A086 |
0.511 |
|
| 1993 |
Nair SK, Christianson DW. Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II Biochemistry. 32: 4506-4514. PMID 8485129 DOI: 10.1021/Bi00068A005 |
0.537 |
|
| 1993 |
Nair SK, Christianson DW. Crystallographic studies of azide binding to human carbonic anhydrase II European Journal of Biochemistry. 213: 507-515. PMID 8477723 DOI: 10.1111/J.1432-1033.1993.Tb17788.X |
0.527 |
|
| 1991 |
Alexander RS, Nair SK, Christianson DW. Engineering the hydrophobic pocket of carbonic anhydrase II. Biochemistry. 30: 11064-72. PMID 1932029 DOI: 10.1021/Bi00110A008 |
0.565 |
|
| 1991 |
Nair SK, Calderone TL, Christianson DW, Fierke CA. Altering the mouth of a hydrophobic pocket: Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121 Journal of Biological Chemistry. 266: 17320-17325. PMID 1910042 DOI: 10.2210/Pdb12Ca/Pdb |
0.555 |
|
| 1991 |
Nair SK, Christianson DW. Structural properties of human carbonic anhydrase II at pH 9.5 Biochemical and Biophysical Research Communications. 181: 579-584. PMID 1755840 DOI: 10.1016/0006-291X(91)91229-6 |
0.472 |
|
| 1991 |
Nair SK, Christianson DW. Unexpected pH-dependent conformation of his-64, the proton shuttle of carbonic anhydrase II Journal of the American Chemical Society. 113: 9455-9458. DOI: 10.1021/Ja00025A005 |
0.403 |
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