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Miguel Holmgren - Publications

Affiliations: 
National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States 
Area:
Molecular Neurophysiology
Website:
http://neuroscience.nih.gov/Lab.asp?Org_ID=409

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Marquez-Miranda V, Rojas M, Duarte Y, Diaz-Franulic I, Holmgren M, Cachau RE, Gonzalez-Nilo FD. Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites. Biorxiv : the Preprint Server For Biology. PMID 33106803 DOI: 10.1101/2020.10.22.349522  0.351
2020 Moreno C, Yano S, Bezanilla F, Latorre R, Holmgren M. Transient Electrical Currents Mediated by the Na/K-ATPase: A Tour from Basic Biophysics to Human Diseases. Biophysical Journal. PMID 32579966 DOI: 10.1016/J.Bpj.2020.06.006  0.731
2020 Vadillo CM, Holmgren M. ATP1A3-Disease Mutations at the Ion Binding Sites Unravel Sequential Release of Na+ in the HNA+/K+ ATPase Alpha 3 Biophysical Journal. 118: 18a. DOI: 10.1016/j.bpj.2019.11.282  0.32
2020 Srivastava S, Miranda P, Giráldez T, Holmgren M. Labeling and Purification of BK Channel for Single Molecule Experiments Biophysical Journal. 118: 271a-272a. DOI: 10.1016/J.Bpj.2019.11.1563  0.662
2019 Vergara-Jaque A, Palma-Cerda F, Lowet AS, de la Cruz Landrau A, Poblete H, Sukharev A, Comer J, Holmgren M. A Structural Model of the Inactivation Gate of Voltage Activated Potassium Channels. Biophysical Journal. PMID 31278002 DOI: 10.1016/J.Bpj.2019.06.008  0.523
2019 Holmgren M, Vergara-Jaque A, Poblete H, Palma F, Lowet AS, Cruz Ladrau Adl, Sukharev A, Comer J. A Structural Model of Fast Inactivation in Shaker KV Channels Biophysical Journal. 116: 544a. DOI: 10.1016/J.BPJ.2018.11.2923  0.344
2018 Miranda P, Holmgren M, Giraldez T. Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor. Elife. 7. PMID 30526860 DOI: 10.7554/Elife.40664  0.751
2018 Lopez-Rodriguez A, Holmgren M. Deglycosylation of Shaker K channels affects voltage sensing and the open-closed transition. The Journal of General Physiology. PMID 29880580 DOI: 10.1085/Jgp.201711958  0.53
2018 Mathur C, Johnson KR, Tong BA, Miranda P, Srikumar D, Basilio D, Latorre R, Bezanilla F, Holmgren M. Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation. Scientific Reports. 8: 2207. PMID 29396520 DOI: 10.1038/S41598-018-20684-8  0.766
2018 Miranda P, Holmgren M, Giraldez T. Author response: Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor Elife. DOI: 10.7554/Elife.40664.014  0.723
2018 Moreno Vadillo C, Holmgren M. Beta-Dependent Modulation of Na+ Binding and Release of the Alpha-3 Na+K+Pump Biophysical Journal. 114: 147a. DOI: 10.1016/j.bpj.2017.11.825  0.306
2017 Bocksteins E, Snyders DJ, Holmgren M. Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers. Scientific Reports. 7: 41646. PMID 28139741 DOI: 10.1038/Srep41646  0.475
2017 Sánchez-Rodríguez JE, Rui H, Roux B, Holmgren M, Bezanilla F. Tuning Voltage Dependent Transitions during the Extracellular Na + Binding/Release of the Na + /K + -ATPase by External Protons Biophysical Journal. 112: 569a-570a. DOI: 10.1016/J.Bpj.2016.11.3068  0.657
2017 Rui H, Sanchez-Rodriguez J, Holmgren M, Bezanilla F, Roux B. Ion Binding and Charge Movements in the Function of the Na/K-Pump Biophysical Journal. 112: 569a. DOI: 10.1016/J.Bpj.2016.11.3067  0.615
2017 Miranda P, Giraldez T, Holmgren M. BK Channel Gating-Ring Voltage Dependence Motions Biophysical Journal. 112: 39a. DOI: 10.1016/J.Bpj.2016.11.249  0.756
2016 Miranda P, Giraldez T, Holmgren M. Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872281 DOI: 10.1073/Pnas.1611415113  0.748
2016 de la Cruz Landrau AA, Holmgren M. Multiple Metal Bridges at the Intracellular Gate of a Voltage Activated Potassium Channel Prevent Closing Biophysical Journal. 110: 601a. DOI: 10.1016/J.BPJ.2015.11.3212  0.379
2016 Rotella C, Kilpatrick JI, Capponi S, Holmgren M, Bezanilla F, Perozo E, Jarvis SP. High Resolution Imaging Atomic Force Microscope Study of Interactions at the Membrane-Fluid Interface Biophysical Journal. 110: 580a-581a. DOI: 10.1016/J.Bpj.2015.11.3103  0.704
2016 Miranda P, Giraldez T, Holmgren M. Selective Cation Binding to the Gating-Ring Triggers Independent RCK Motions in the BK Channel Biophysical Journal. 110: 187a. DOI: 10.1016/J.Bpj.2015.11.1041  0.735
2015 Castillo JP, Rui H, Basilio D, Das A, Roux B, Latorre R, Bezanilla F, Holmgren M. Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase. Nature Communications. 6: 7622. PMID 26205423 DOI: 10.1038/Ncomms8622  0.816
2015 Sánchez-Rodríguez JE, Khalili-Araghi F, Miranda P, Roux B, Holmgren M, Bezanilla F. A structural rearrangement of the Na+/K+-ATPase traps ouabain within the external ion permeation pathway. Journal of Molecular Biology. 427: 1335-44. PMID 25637661 DOI: 10.1016/J.Jmb.2015.01.011  0.631
2015 Sánchez-Rodríguez JE, Miranda-Fernández P, Holmgren M, Bezanilla F. Voltage Dependent Conformational Changes of the Na+/K+-ATPase Revealed by Site Directed Fluorometry Biophysical Journal. 108: 144a. DOI: 10.1016/J.Bpj.2014.11.795  0.636
2015 Miranda P, Giraldez T, Holmgren M. Voltage Dependence of BK Channels Gating Ring Motion Studied by State Dependent FRET Biophysical Journal. 108: 119a. DOI: 10.1016/J.Bpj.2014.11.666  0.755
2015 Bocksteins E, Snyders DJ, Holmgren M. Movements of the Kv2.1 and Kv6.4 S4 Segments in Heterotetrameric Kv2.1/Kv6.4 Channels Biophysical Journal. 108: 117a. DOI: 10.1016/J.Bpj.2014.11.656  0.495
2014 Holmgren M, Rosenthal JJ. Regulation of Ion Channel and Transporter Function Through RNA Editing. Current Issues in Molecular Biology. 17: 23-36. PMID 25347917  0.427
2014 Venkataraman G, Srikumar D, Holmgren M. Quasi-specific access of the potassium channel inactivation gate. Nature Communications. 5: 4050. PMID 24909510 DOI: 10.1038/Ncomms5050  0.563
2014 Oelstrom K, Goldschen-Ohm MP, Holmgren M, Chanda B. Evolutionarily conserved intracellular gate of voltage-dependent sodium channels. Nature Communications. 5: 3420. PMID 24619022 DOI: 10.1038/Ncomms4420  0.566
2014 Sánchez-Rodríguez JE, Miranda-Fernández P, Holmgren M, Bezanilla F. Conformational Rearrangements of the Na+/K+ ATPase During Na+ Occlusion/Deocclusion Transitions Assessed by Site-Directed Fluorescence Biophysical Journal. 106: 582a. DOI: 10.1016/J.Bpj.2013.11.3226  0.623
2014 Castillo JP, Basilio D, Latorre R, Bezanilla F, Holmgren M. K+ Translocation by the Giant Axon of the Humboldt Squid Na+/K ATPase Biophysical Journal. 106: 582a. DOI: 10.1016/J.Bpj.2013.11.3225  0.812
2014 de la Cruz Landrau AA, Holmgren M. Locking the Open State of a Voltage-Dependent Concatemer Potassium Channel with Metal Bridges Biophysical Journal. 106: 537a. DOI: 10.1016/J.BPJ.2013.11.2997  0.369
2014 Lopez-Rodriguez AM, Venkataraman G, Holmgren M. Shaker Kv Channel's Sugar Remotion in Real-Time Biophysical Journal. 106: 537a. DOI: 10.1016/J.BPJ.2013.11.2996  0.312
2014 Miranda P, Giraldez T, Holmgren M. Divalent Cation-Dependent Motion of the BK Channel Gating-Ring Reported by State Dependent FRET Biophysical Journal. 106: 436a-437a. DOI: 10.1016/J.Bpj.2013.11.2459  0.735
2013 Miranda P, Contreras JE, Plested AJ, Sigworth FJ, Holmgren M, Giraldez T. State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 5217-22. PMID 23479636 DOI: 10.1073/Pnas.1219611110  0.762
2013 Venkataraman G, Srikumar D, Holmgren M. Access Constraints and Binding Energetics of a Potassium Channel Inactivation Gate Biophysical Journal. 104: 127a. DOI: 10.1016/j.bpj.2012.11.727  0.414
2013 Sánchez-Rodríguez JE, Khalili-Araghi F, Adhikari A, Sosnick T, Roux B, Holmgren M, Bezanilla F. Probing Conformational Changes of the Na+/K+ ATPase upon Ouabain Binding by using a Spectroscopic Approach Biophysical Journal. 104: 300a. DOI: 10.1016/J.Bpj.2012.11.1669  0.63
2013 Oelstrom K, Holmgren M, Chanda B. Access to the Pore of a Voltage-Dependent Na+ Channel is Controlled by an Intracellular Gate Biophysical Journal. 104: 13a. DOI: 10.1016/J.BPJ.2012.11.105  0.469
2012 Lopez-Rodriguez A, Holmgren M. Restoration of proper trafficking to the cell surface for membrane proteins harboring cysteine mutations. Plos One. 7: e47693. PMID 23082193 DOI: 10.1371/Journal.Pone.0047693  0.37
2012 Gadsby DC, Bezanilla F, Rakowski RF, De Weer P, Holmgren M. The dynamic relationships between the three events that release individual Na⁺ ions from the Na⁺/K⁺-ATPase. Nature Communications. 3: 669. PMID 22334072 DOI: 10.1038/Ncomms1673  0.662
2012 Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F. Energetics of the Reactions Controlling the Deeply Occluded State of the Na+/K+ Pump Biophysical Journal. 102: 708a. DOI: 10.1016/j.bpj.2011.11.3845  0.808
2012 Holmgren M, Gadsby DC, Bezanilla F, Rakowski RF, De Weer P. Na+ Access Kinetics in the Na+/K+-Atpase Pump Biophysical Journal. 102: 708a. DOI: 10.1016/J.Bpj.2011.11.3844  0.632
2012 Sanchez-Rodriguez JE, Khalili-Araghi F, Roux B, Holmgren M, Bezanilla F. Changes of Intramolecular Distances in the Na+/K+ Atpase upon Ouabain Binding Biophysical Journal. 102: 708a. DOI: 10.1016/J.Bpj.2011.11.3843  0.649
2012 Miranda P, Contreras JE, Wesch D, Sigworth FJ, Holmgren M, Giraldez T. State-Dependent FRET Reports Large Gating-Ring Motions in BK Channels Biophysical Journal. 102: 687a. DOI: 10.1016/J.Bpj.2011.11.3735  0.768
2011 Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F. Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proceedings of the National Academy of Sciences of the United States of America. 108: 20556-61. PMID 22143771 DOI: 10.1073/Pnas.1116439108  0.808
2011 Sandtner W, Egwolf B, Khalili-Araghi F, Sánchez-Rodríguez JE, Roux B, Bezanilla F, Holmgren M. Ouabain binding site in a functioning Na+/K+ ATPase. The Journal of Biological Chemistry. 286: 38177-83. PMID 21911500 DOI: 10.1074/Jbc.M111.267682  0.615
2011 Gonzalez C, Lopez-Rodriguez A, Srikumar D, Rosenthal JJ, Holmgren M. Editing of human K(V)1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity. Nature Communications. 2: 436. PMID 21847110 DOI: 10.1038/Ncomms1446  0.629
2011 Galarza-Muñoz G, Soto-Morales SI, Holmgren M, Rosenthal JJ. Physiological adaptation of an Antarctic Na+/K+-ATPase to the cold. The Journal of Experimental Biology. 214: 2164-74. PMID 21653810 DOI: 10.1242/Jeb.048744  0.421
2011 Miranda P, Contreras J, Wesch DL, Sigworth FJ, Holmgren M, Giraldez T. Calcium Induces Structural Rearrangements of the Gating Ring of the Human BK Channel Biophysical Journal. 100: 260a. DOI: 10.1016/J.Bpj.2010.12.1636  0.758
2010 Colina C, Palavicini JP, Srikumar D, Holmgren M, Rosenthal JJ. Regulation of Na+/K+ ATPase transport velocity by RNA editing. Plos Biology. 8: e1000540. PMID 21124885 DOI: 10.1371/Journal.Pbio.1000540  0.475
2010 Contreras JE, Chen J, Lau AY, Jogini V, Roux B, Holmgren M. Voltage profile along the permeation pathway of an open channel. Biophysical Journal. 99: 2863-9. PMID 21044583 DOI: 10.1016/J.Bpj.2010.08.053  0.48
2010 Lopez-Rodriguez A, Holmgren M. Transferring S3-S4 Motif from Kv Channels to the CNG Channel Biophysical Journal. 98: 707a. DOI: 10.1016/J.Bpj.2009.12.3878  0.553
2008 Contreras JE, Srikumar D, Holmgren M. Gating at the selectivity filter in cyclic nucleotide-gated channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 3310-4. PMID 18287006 DOI: 10.1073/Pnas.0709809105  0.51
2007 Rakowski RF, Artigas P, Palma F, Holmgren M, De Weer P, Gadsby DC. Sodium flux ratio in Na/K pump-channels opened by palytoxin. The Journal of General Physiology. 130: 41-54. PMID 17562821 DOI: 10.1085/jgp.200709770  0.532
2007 Colina C, Rosenthal JJ, DeGiorgis JA, Srikumar D, Iruku N, Holmgren M. Structural basis of Na(+)/K(+)-ATPase adaptation to marine environments. Nature Structural & Molecular Biology. 14: 427-31. PMID 17460695 DOI: 10.1038/Nsmb1237  0.491
2006 Contreras JE, Holmgren M. Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate. The Journal of General Physiology. 127: 481-94. PMID 16606688 DOI: 10.1085/Jgp.200509440  0.545
2006 Holmgren M, Rakowski RF. Charge translocation by the Na+/K+ pump under Na+/Na+ exchange conditions: intracellular Na+ dependence. Biophysical Journal. 90: 1607-16. PMID 16326910 DOI: 10.1529/Biophysj.105.072942  0.501
2004 Bhalla T, Rosenthal JJ, Holmgren M, Reenan R. Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nature Structural & Molecular Biology. 11: 950-6. PMID 15361858 DOI: 10.1038/Nsmb825  0.488
2003 Soler-Llavina GJ, Holmgren M, Swartz KJ. Defining the conductance of the closed state in a voltage-gated K+ channel. Neuron. 38: 61-7. PMID 12691664 DOI: 10.1016/S0896-6273(03)00157-0  0.556
2003 Holmgren M. Influence of permeant ions on gating in cyclic nucleotide-gated channels. The Journal of General Physiology. 121: 61-72. PMID 12508054 DOI: 10.1085/Jgp.20028722  0.596
2000 Holmgren M, Wagg J, Bezanilla F, Rakowski RF, De Weer P, Gadsby DC. Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase. Nature. 403: 898-901. PMID 10706288 DOI: 10.1038/35002599  0.599
2000 del Camino D, Holmgren M, Liu Y, Yellen G. Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature. 403: 321-5. PMID 10659852 DOI: 10.1038/35002099  0.81
1998 Holmgren M, Shin KS, Yellen G. The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge. Neuron. 21: 617-21. PMID 9768847 DOI: 10.1016/S0896-6273(00)80571-1  0.778
1997 Rakowski RF, Bezanilla F, De Weer P, Gadsby DC, Holmgren M, Wagg J. Charge translocation by the Na/K pump. Annals of the New York Academy of Sciences. 834: 231-43. PMID 9405811 DOI: 10.1111/J.1749-6632.1997.Tb52254.X  0.551
1997 Liu Y, Holmgren M, Jurman ME, Yellen G. Gated access to the pore of a voltage-dependent K+ channel. Neuron. 19: 175-84. PMID 9247273 DOI: 10.1016/S0896-6273(00)80357-8  0.749
1997 Holmgren M, Smith PL, Yellen G. Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating. The Journal of General Physiology. 109: 527-35. PMID 9154902 DOI: 10.1085/jgp.109.5.527  0.72
1996 Holmgren M, Liu Y, Xu Y, Yellen G. On the use of thiol-modifying agents to determine channel topology. Neuropharmacology. 35: 797-804. PMID 8938712 DOI: 10.1016/0028-3908(96)00129-3  0.652
1996 Holmgren M, Jurman ME, Yellen G. N-type inactivation and the S4-S5 region of the Shaker K+ channel. The Journal of General Physiology. 108: 195-206. PMID 8882863 DOI: 10.1085/Jgp.108.3.195  0.669
1994 Holmgren M, Rakowski RF. Pre-steady-state transient currents mediated by the Na/K pump in internally perfused Xenopus oocytes. Biophysical Journal. 66: 912-22. PMID 8011923  0.413
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