| Year |
Citation |
Score |
| 2015 |
Cowan CS, Abd-El-Barr M, van der Heijden M, Lo EM, Paul D, Bramblett DE, Lem J, Simons DL, Wu SM. Connexin 36 and Rod Bipolar Cell Independent Rod Pathways Drive Retinal Ganglion Cells and Optokinetic Reflexes. Vision Research. PMID 26718442 DOI: 10.1016/J.Visres.2015.11.006 |
0.518 |
|
| 2012 |
Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G. Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. Plos One. 7: e37832. PMID 22662234 DOI: 10.1371/Journal.Pone.0037832 |
0.424 |
|
| 2010 |
Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proceedings of the National Academy of Sciences of the United States of America. 107: 8428-33. PMID 20404157 DOI: 10.1073/Pnas.1000640107 |
0.579 |
|
| 2010 |
Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM. Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry. Proceedings of the National Academy of Sciences of the United States of America. 107: 395-400. PMID 20018684 DOI: 10.1073/Pnas.0907178107 |
0.455 |
|
| 2009 |
Malanson KM, Lem J. Rhodopsin-mediated retinitis pigmentosa. Progress in Molecular Biology and Translational Science. 88: 1-31. PMID 20374723 DOI: 10.1016/S1877-1173(09)88001-0 |
0.616 |
|
| 2009 |
Abd-El-Barr MM, Pennesi ME, Saszik SM, Barrow AJ, Lem J, Bramblett DE, Paul DL, Frishman LJ, Wu SM. Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. Journal of Neurophysiology. 102: 1945-55. PMID 19587322 DOI: 10.1152/Jn.00142.2009 |
0.414 |
|
| 2009 |
Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 48: 4294-304. PMID 19348429 DOI: 10.1021/Bi900417B |
0.407 |
|
| 2009 |
Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL. Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophysical Journal. 96: 939-50. PMID 19186132 DOI: 10.1016/J.Bpj.2008.10.016 |
0.381 |
|
| 2009 |
Wen X, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, DiBenedetto E, Anderson RE, Makino CL. Revamped Outer Segment Structure and Photoresponse in Retinal Rods Over-expressing Rhodopsin Biophysical Journal. 96: 525a. DOI: 10.1016/J.Bpj.2008.12.2708 |
0.409 |
|
| 2007 |
Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J. A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin. Investigative Ophthalmology & Visual Science. 48: 5445-53. PMID 18055791 DOI: 10.1167/Iovs.06-1402 |
0.628 |
|
| 2007 |
Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5484-94. PMID 17507570 DOI: 10.1523/Jneurosci.1421-07.2007 |
0.396 |
|
| 2007 |
Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. The Journal of Biological Chemistry. 282: 9865-73. PMID 17272282 DOI: 10.1074/Jbc.M608845200 |
0.456 |
|
| 2006 |
Bemelmans AP, Kostic C, Hornfeld D, Jaquet M, Crippa SV, Hauswirth WW, Lem J, Wang Z, Schorderet DE, Munier FL, Wenzel A, Arsenijevic Y. Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA. Advances in Experimental Medicine and Biology. 572: 247-53. PMID 17249581 DOI: 10.1007/0-387-32442-9_35 |
0.379 |
|
| 2006 |
Bemelmans AP, Kostic C, Crippa SV, Hauswirth WW, Lem J, Munier FL, Seeliger MW, Wenzel A, Arsenijevic Y. Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis. Plos Medicine. 3: e347. PMID 17032058 DOI: 10.1371/Journal.Pmed.0030347 |
0.585 |
|
| 2006 |
Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO. Phototransduction in a transgenic mouse model of Nougaret night blindness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6863-72. PMID 16793893 DOI: 10.1523/Jneurosci.1322-06.2006 |
0.544 |
|
| 2006 |
Nikonov SS, Kholodenko R, Lem J, Pugh EN. Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. The Journal of General Physiology. 127: 359-74. PMID 16567464 DOI: 10.1085/Jgp.200609490 |
0.464 |
|
| 2006 |
Bemelmans A, Kostic C, Hornfeld D, Tekaya M, Crippa SV, Hauswirth WW, Lem J, Seeliger M, Wenzel A, Arsenijevic Y. 419. Rescue of Cone Photoreceptors after Lentiviral Gene Transfer of Rpe65 cDNA in Knockout Mouse Models of Leber Congenital Amaurosis Molecular Therapy. 13: S161. DOI: 10.1016/J.Ymthe.2006.08.483 |
0.509 |
|
| 2005 |
Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Investigative Ophthalmology & Visual Science. 46: 4320-7. PMID 16249514 DOI: 10.1167/Iovs.05-0478 |
0.493 |
|
| 2005 |
Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J. Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin. The Journal of Biological Chemistry. 280: 24293-300. PMID 15851469 DOI: 10.1074/Jbc.M502588200 |
0.519 |
|
| 2005 |
Kostic C, Bemelmans A, Jaquet M, Hornfeld D, Hauswirth WW, Lem J, Wang Z, Schorderet DF, Munier FL, Wenzel A, Arsenijevic Y. 667. Lentiviral Gene Transfer of RPE65 cDNA in Knock-Out Mouse Models of Leber Congenital Amaurosis Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.207 |
0.477 |
|
| 2004 |
Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H. Retinal abnormalities associated with the G90D mutation in opsin. The Journal of Comparative Neurology. 478: 149-63. PMID 15349976 DOI: 10.1002/Cne.20283 |
0.576 |
|
| 2004 |
He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomiya Y, Margolskee RF, Damak S. Umami taste responses are mediated by alpha-transducin and alpha-gustducin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7674-80. PMID 15342734 DOI: 10.1523/Jneurosci.2441-04.2004 |
0.364 |
|
| 2004 |
Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C. New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 277-83. PMID 15112105 DOI: 10.1007/S00335-003-2336-2 |
0.44 |
|
| 2004 |
Woodruff ML, Lem J, Fain GL. Early receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ release. The Journal of Physiology. 557: 821-8. PMID 15073279 DOI: 10.1113/Jphysiol.2004.064014 |
0.431 |
|
| 2004 |
Lem J, Fain GL. Constitutive opsin signaling: night blindness or retinal degeneration? Trends in Molecular Medicine. 10: 150-7. PMID 15059605 DOI: 10.1016/J.Molmed.2004.02.009 |
0.577 |
|
| 2004 |
Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H. Erratum: Retinal abnormalities associated with the G90D mutation in opsin (The Journal of Comparative Neurology (2004) 478 (149-163)) The Journal of Comparative Neurology. 480. DOI: 10.1002/Cne.20373 |
0.522 |
|
| 2003 |
Brill E, Patnala S, Lem J, Obin M. Bright light induces retinal degeneration by a transducin-independent mechanism. Advances in Experimental Medicine and Biology. 533: 213-9. PMID 15180267 DOI: 10.1007/978-1-4615-0067-4_27 |
0.461 |
|
| 2003 |
Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10175-81. PMID 14614075 DOI: 10.1523/Jneurosci.23-32-10175.2003 |
0.343 |
|
| 2003 |
Woodruff ML, Wang Z, Chung HY, Redmond TM, Fain GL, Lem J. Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis. Nature Genetics. 35: 158-64. PMID 14517541 DOI: 10.1038/Ng1246 |
0.594 |
|
| 2003 |
Makino CL, Wen XH, Lem J. Piecing together the timetable for visual transduction with transgenic animals. Current Opinion in Neurobiology. 13: 404-12. PMID 12965286 DOI: 10.1016/S0959-4388(03)00091-6 |
0.398 |
|
| 2003 |
Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau KW. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature. 424: 76-81. PMID 12808468 DOI: 10.1038/Nature01761 |
0.491 |
|
| 2003 |
Mendez A, Lem J, Simon M, Chen J. Light-Dependent Translocation of Arrestin in the Absence of Rhodopsin Phosphorylation and Transducin Signaling The Journal of Neuroscience. 23: 3124-3129. DOI: 10.1523/Jneurosci.23-08-03124.2003 |
0.396 |
|
| 2002 |
Hao W, Wenzel A, Obin MS, Chen CK, Brill E, Krasnoperova NV, Eversole-Cire P, Kleyner Y, Taylor A, Simon MI, Grimm C, Remé CE, Lem J. Evidence for two apoptotic pathways in light-induced retinal degeneration. Nature Genetics. 32: 254-60. PMID 12219089 DOI: 10.1038/Ng984 |
0.496 |
|
| 2002 |
Woodruff ML, Sampath AP, Matthews HR, Krasnoperova NV, Lem J, Fain GL. Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice. The Journal of Physiology. 542: 843-54. PMID 12154183 DOI: 10.1113/Jphysiol.2001.013987 |
0.327 |
|
| 2002 |
Lyubarsky AL, Lem J, Chen J, Falsini B, Iannaccone A, Pugh EN. Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. Vision Research. 42: 401-15. PMID 11853756 DOI: 10.1016/S0042-6989(01)00214-0 |
0.497 |
|
| 2001 |
Calvert PD, Govardovskii VI, Krasnoperova N, Anderson RE, Lem J, Makino CL. Membrane protein diffusion sets the speed of rod phototransduction. Nature. 411: 90-4. PMID 11333983 DOI: 10.1038/35075083 |
0.341 |
|
| 2001 |
Liang FQ, Dejneka NS, Cohen DR, Krasnoperova NV, Lem J, Maguire AM, Dudus L, Fisher KJ, Bennett J. AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 241-8. PMID 11237681 DOI: 10.1006/Mthe.2000.0252 |
0.482 |
|
| 2000 |
Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicoló M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN, Makino CL, Lem J. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit. Proceedings of the National Academy of Sciences of the United States of America. 97: 13913-8. PMID 11095744 DOI: 10.1073/Pnas.250478897 |
0.574 |
|
| 2000 |
Mendez A, Burns ME, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J. Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron. 28: 153-64. PMID 11086991 DOI: 10.1016/S0896-6273(00)00093-3 |
0.347 |
|
| 2000 |
Mendez A, Krasnoperova NV, Lem J, Chen J. Functional study of rhodopsin phosphorylation in vivo. Methods in Enzymology. 316: 167-85. PMID 10800675 DOI: 10.1016/S0076-6879(00)16723-0 |
0.423 |
|
| 1999 |
Lem J, Krasnoperova NV, Calvert PD, Kosaras B, Cameron DA, Nicolò M, Makino CL, Sidman RL. Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 736-41. PMID 9892703 DOI: 10.1073/Pnas.96.2.736 |
0.6 |
|
| 1998 |
Lem J. Diseases of G-Protein-Coupled Signal Transduction Pathways: The Mammalian Visual System as a Model Seminars in Neuroscience. 9: 232-239. DOI: 10.1006/Smns.1998.0126 |
0.367 |
|
| 1996 |
Lem J, Makino CL. Phototransduction in transgenic mice. Current Opinion in Neurobiology. 6: 453-8. PMID 8794096 DOI: 10.1016/S0959-4388(96)80049-3 |
0.47 |
|
| 1992 |
Lem J, Flannery JG, Li T, Applebury ML, Farber DB, Simon MI. Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase beta subunit. Proceedings of the National Academy of Sciences of the United States of America. 89: 4422-6. PMID 1350091 DOI: 10.1073/Pnas.89.10.4422 |
0.469 |
|
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