Krzysztof Palczewski - Publications

Affiliations: 
1997 Pharmacology University of Washington, Seattle, Seattle, WA 

214 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Organic & Biomolecular Chemistry. PMID 31455964 DOI: 10.1039/c9ob01645g  0.64
2019 Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. PMID 31400484 DOI: 10.1016/j.neuroscience.2019.07.047  0.64
2019 Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. The Journal of Biological Chemistry. PMID 31399513 DOI: 10.1074/jbc.RA119.010089  0.64
2019 Kahremany S, Kubas A, Tochtrop GP, Palczewski K. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Transactions (Cambridge, England : 2003). PMID 31218312 DOI: 10.1039/c9dt02189b  0.64
2019 Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900443RR. PMID 31121099 DOI: 10.1096/fj.201900443RR  0.96
2019 Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. The Journal of Biological Chemistry. PMID 31073029 DOI: 10.1074/jbc.RA119.008697  0.96
2019 Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Investigative Ophthalmology & Visual Science. 60: 1538-1546. PMID 30994864 DOI: 10.1167/iovs.18-26433  0.56
2019 Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. The Journal of Biological Chemistry. PMID 30948514 DOI: 10.1074/jbc.RA118.006835  0.52
2019 Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Investigative Ophthalmology & Visual Science. 60: 1442-1453. PMID 30947334 DOI: 10.1167/iovs.19-26560  0.4
2019 Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Science Advances. 5: eaav4322. PMID 30820458 DOI: 10.1126/sciadv.aav4322  0.36
2019 Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. The Journal of Biological Chemistry. PMID 30770468 DOI: 10.1074/jbc.RA119.007587  0.56
2019 Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802493R. PMID 30645148 DOI: 10.1096/fj.201802493R  0.64
2019 Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods in Molecular Biology (Clifton, N.J.). 1834: 333-343. PMID 30324453 DOI: 10.1007/978-1-4939-8669-9_21  0.56
2019 Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods in Molecular Biology (Clifton, N.J.). 1834: 311-332. PMID 30324452 DOI: 10.1007/978-1-4939-8669-9_20  0.48
2018 Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801662R. PMID 30462532 DOI: 10.1096/fj.201801662R  1
2018 Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-opsin exists in equilibrium between a predominant inactive and a rare highly active state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30459230 DOI: 10.1523/JNEUROSCI.1980-18.2018  0.56
2018 Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-retinaldehyde production in the classical visual cycle. The Biochemical Journal. 475: 3171-3188. PMID 30352831 DOI: 10.1042/BCJ20180193  0.64
2018 Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chemical Science. 9: 6480-6489. PMID 30310578 DOI: 10.1039/c8sc01680a  0.6
2018 Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. Iscience. 4: 1-19. PMID 30240733 DOI: 10.1016/j.isci.2018.05.001  0.4
2018 Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. Jci Insight. 3. PMID 30185665 DOI: 10.1172/jci.insight.121555  0.56
2018 Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective effect of a locked retinal chromophore analogue against light-induced retinal degeneration. Molecular Pharmacology. PMID 30018116 DOI: 10.1124/mol.118.112581  0.64
2018 Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nature Communications. 9: 1996. PMID 29777099 DOI: 10.1038/s41467-018-04432-0  0.64
2018 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, ... ... Palczewski K, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nature Communications. 9: 1976. PMID 29773803 DOI: 10.1038/s41467-018-04261-1  0.96
2018 Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Human Molecular Genetics. PMID 29659842 DOI: 10.1093/hmg/ddy128  0.64
2018 Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. The Journal of General Physiology. PMID 29500274 DOI: 10.1085/jgp.201711815  0.64
2018 Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan conjugates effectively deliver active chromophores to retinal photoreceptor cells in blind mice and dogs. Molecular Pharmacology. PMID 29453250 DOI: 10.1124/mol.117.111294  0.64
2018 Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701250R. PMID 29401616 DOI: 10.1096/fj.201701250R  0.96
2018 Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. PMID 29320632 DOI: 10.1021/acs.biochem.7b01118  0.56
2017 Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomedical Optics Express. 8: 5228-5242. PMID 29188116 DOI: 10.1364/BOE.8.005228  0.52
2017 Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A therapeutic combination of GPCR modulators that protects photoreceptors from degeneration. The Journal of Pharmacology and Experimental Therapeutics. PMID 29162627 DOI: 10.1124/jpet.117.245167  0.64
2017 Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Scientific Reports. 7: 14623. PMID 29116131 DOI: 10.1038/s41598-017-15191-1  0.64
2017 Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078372 DOI: 10.1073/pnas.1712405114  0.52
2017 Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proceedings of Spie--the International Society For Optical Engineering. 10069. PMID 28989217 DOI: 10.1117/12.2252457  0.52
2017 Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends in Pharmacological Sciences. PMID 28935293 DOI: 10.1016/j.tips.2017.08.004  0.6
2017 Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Science : a Publication of the Protein Society. PMID 28762619 DOI: 10.1002/pro.3247  0.36
2017 Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. PMID 28755268 DOI: 10.1007/s00125-017-4381-5  0.56
2017 Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Molecular Therapy. Nucleic Acids. 7: 42-52. PMID 28624218 DOI: 10.1016/j.omtn.2017.02.005  0.52
2017 Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Scientific Reports. 7: 2390. PMID 28539612 DOI: 10.1038/s41598-017-02549-8  0.52
2017 Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop G, Palczewski K, Hendrich MP, Kiser PD. Structure and spectroscopy of alkene-cleaving dioxygenases containing an atypically coordinated non-heme iron center. Biochemistry. PMID 28493664 DOI: 10.1021/acs.biochem.7b00251  0.64
2017 Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. The Journal of Biological Chemistry. PMID 28487362 DOI: 10.1074/jbc.M117.780478  0.64
2017 Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational tuning of visual cycle modulator pharmacodynamics. The Journal of Pharmacology and Experimental Therapeutics. PMID 28476927 DOI: 10.1124/jpet.117.240721  0.64
2017 Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. PMID 28402104 DOI: 10.1021/acs.biochem.7b00165  0.64
2017 Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28289214 DOI: 10.1073/pnas.1617446114  0.64
2017 Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Investigative Ophthalmology & Visual Science. 58: 604-613. PMID 28129424 DOI: 10.1167/iovs.16-20061  0.52
2017 Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. microRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. The Journal of Biological Chemistry. PMID 28104803 DOI: 10.1074/jbc.M116.770024  0.64
2017 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, ... Palczewski K, et al. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics. PMID 28065882 DOI: 10.1093/hmg/ddw387  0.48
2016 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Human Molecular Genetics. 25: 4376-4388. PMID 28172828 DOI: 10.1093/hmg/ddw268  0.64
2016 Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 61-72. PMID 28045251 DOI: 10.1021/acs.biochem.6b00877  0.56
2016 Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomedical Optics Express. 7: 5148-5169. PMID 28018732 DOI: 10.1364/BOE.7.005148  0.52
2016 Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annual Review of Vision Science. 2: 197-234. PMID 27917399 DOI: 10.1146/annurev-vision-111815-114407  0.64
2016 Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor tyrosine kinase MERTK is not required for transfer of bis-retinoids to the retinal pigmented epithelium. The Journal of Biological Chemistry. PMID 27875314 DOI: 10.1074/jbc.M116.764563  0.64
2016 Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome Profiling of NIH3T3 Cell Lines Expressing Opsin and the P23H Opsin Mutant Identifies Candidate Drugs for the Treatment of Retinitis Pigmentosa. Pharmacological Research. PMID 27838510 DOI: 10.1016/j.phrs.2016.10.031  0.96
2016 Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural insights into the Drosophila melanogaster retinol dehydrogenase, a member of the short-chain dehydrogenase/reductase family. Biochemistry. PMID 27809489 DOI: 10.1021/acs.biochem.6b00907  0.48
2016 Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacological Research. PMID 27720767 DOI: 10.1016/j.phrs.2016.09.026  0.96
2016 Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Research. PMID 27655633 DOI: 10.1093/nar/gkw846  0.4
2016 Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Investigative Ophthalmology & Visual Science. 57: 4272-4281. PMID 27548901 DOI: 10.1167/iovs.16-19415  0.56
2016 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Human Molecular Genetics. PMID 27506984 DOI: 10.1093/hmg/ddw268  0.64
2016 Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Science Signaling. 9: ra74. PMID 27460988 DOI: 10.1126/scisignal.aag0245  0.96
2016 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angewandte Chemie (International Ed. in English). PMID 27460867 DOI: 10.1002/anie.201605147  0.96
2016 Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key residues for catalytic function and metal coordination in a carotenoid cleavage dioxygenase. The Journal of Biological Chemistry. PMID 27453555 DOI: 10.1074/jbc.M116.744912  0.64
2016 Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomedical Optics Express. 7: 2671-91. PMID 27446697 DOI: 10.1364/BOE.7.002671  0.56
2016 Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angewandte Chemie (International Ed. in English). PMID 27244650 DOI: 10.1002/anie.201603766  0.96
2016 Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. Dominant and recessive mutations in rhodopsin activate different cell death pathways. Human Molecular Genetics. PMID 27149983 DOI: 10.1093/hmg/ddw137  0.48
2016 Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational change of human checkpoint kinase 1 (Chk1) induced by DNA damage. The Journal of Biological Chemistry. PMID 27129240 DOI: 10.1074/jbc.M115.713248  0.96
2016 Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, ... ... Palczewski K, et al. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nature Chemical Biology. PMID 27110679 DOI: 10.1038/nchembio.2069  0.96
2016 Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Investigative Ophthalmology & Visual Science. 57: 647-57. PMID 26903225 DOI: 10.1167/iovs.15-17946  0.52
2016 Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Investigative Ophthalmology & Visual Science. 57: 632-46. PMID 26903224 DOI: 10.1167/iovs.15-17961  0.52
2016 Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard RT-PCR device. Analytical Biochemistry. PMID 26851339 DOI: 10.1016/j.ab.2016.01.016  0.96
2016 Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The biochemical basis of vitamin A3 production in arthropod vision. Acs Chemical Biology. PMID 26811964 DOI: 10.1021/acschembio.5b00967  0.96
2015 Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. The Journal of Biological Chemistry. PMID 26499794 DOI: 10.1074/jbc.M115.696799  0.44
2015 Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. A2E Accumulation and the Maintenance of the Visual Cycle are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. The Journal of Biological Chemistry. PMID 26468292 DOI: 10.1074/jbc.M115.682310  0.96
2015 Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomedical Optics Express. 6: 3352-61. PMID 26417507 DOI: 10.1364/BOE.6.003352  0.96
2015 Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. The Journal of Biological Chemistry. PMID 26391396 DOI: 10.1074/jbc.M115.682096  0.96
2015 Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. The Journal of Physiology. PMID 26350353 DOI: 10.1113/JP271285  0.96
2015 Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. The Journal of Biological Chemistry. 290: 25728-44. PMID 26330551 DOI: 10.1074/jbc.M115.662684  0.96
2015 Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomedical Optics Express. 6: 3032-52. PMID 26309765 DOI: 10.1364/BOE.6.003032  0.96
2015 Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. Macromolecular Bioscience. PMID 26271011 DOI: 10.1002/mabi.201500192  0.8
2015 Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opinion On Orphan Drugs. 3: 563-575. PMID 26246977 DOI: 10.1517/21678707.2015.1030393  0.96
2015 Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Investigative Ophthalmology & Visual Science. 56: 4936-42. PMID 26225634 DOI: 10.1167/iovs.15-16522  0.96
2015 Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. Serum levels of lipid metabolites in age-related macular degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26187344 DOI: 10.1096/fj.15-275289  0.96
2015 Hofmann L, Palczewski K. Advances in understanding the molecular basis of the first steps in color vision. Progress in Retinal and Eye Research. 49: 46-66. PMID 26187035 DOI: 10.1016/j.preteyeres.2015.07.004  0.96
2015 Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, Von Lintig J, Palczewski K, Kern TS. Retinylamine Benefits Early Diabetic Retinopathy in Mice. The Journal of Biological Chemistry. PMID 26139608 DOI: 10.1074/jbc.M115.655555  0.96
2015 Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. The Journal of Clinical Investigation. 125: 2781-94. PMID 26075817 DOI: 10.1172/JCI80950  0.96
2015 Yuan S, Palczewski K, Peng Q, Kolinski M, Vogel H, Filipek S. The Mechanism of Ligand-Induced Activation or Inhibition of μ- and κ-Opioid Receptors. Angewandte Chemie (International Ed. in English). 54: 7560-3. PMID 25968837 DOI: 10.1002/anie.201501742  0.96
2015 Baker BY, Gulati S, Shi W, Wang B, Stewart PL, Palczewski K. Crystallization of proteins from crude bovine rod outer segments. Methods in Enzymology. 557: 439-58. PMID 25950977 DOI: 10.1016/bs.mie.2014.11.045  0.96
2015 Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nature Chemical Biology. 11: 409-15. PMID 25894083 DOI: 10.1038/nchembio.1799  0.96
2015 Chen Y, Palczewski K. Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annual Review of Pharmacology and Toxicology. PMID 25839098 DOI: 10.1146/annurev-pharmtox-010715-103033  0.96
2015 Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Investigative Ophthalmology & Visual Science. 56: 2553-67. PMID 25783607 DOI: 10.1167/iovs.14-16298  0.96
2015 Zhang N, Tsybovsky Y, Kolesnikov AV, Rozanowska M, Swider M, Schwartz SB, Stone EM, Palczewska G, Maeda A, Kefalov VJ, Jacobson SG, Cideciyan AV, Palczewski K. Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Human Molecular Genetics. 24: 3220-37. PMID 25712131 DOI: 10.1093/hmg/ddv073  0.96
2015 Hofmann L, Palczewski K. The G protein-coupled receptor rhodopsin: a historical perspective. Methods in Molecular Biology (Clifton, N.J.). 1271: 3-18. PMID 25697513 DOI: 10.1007/978-1-4939-2330-4_1  0.96
2015 Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2194-204. PMID 25667222 DOI: 10.1096/fj.14-269431  0.96
2015 Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials. 44: 103-10. PMID 25617130 DOI: 10.1016/j.biomaterials.2014.12.019  0.96
2015 Kevany BM, Zhang N, Jastrzebska B, Palczewski K. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Human Molecular Genetics. 24: 2627-40. PMID 25616964 DOI: 10.1093/hmg/ddv025  0.96
2015 Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Molecular Pharmacology. 87: 477-91. PMID 25538117 DOI: 10.1124/mol.114.096560  0.96
2015 Salom D, Cao P, Yuan Y, Miyagi M, Feng Z, Palczewski K. Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans. Analytical Biochemistry. 472: 30-6. PMID 25461480 DOI: 10.1016/j.ab.2014.11.008  0.96
2015 Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nature Chemical Biology. 11: 26-32. PMID 25383759 DOI: 10.1038/nchembio.1687  0.96
2015 Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Molecular Neurobiology. 52: 679-95. PMID 25270370 DOI: 10.1007/s12035-014-8881-8  0.96
2015 Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells Macromolecular Bioscience. DOI: 10.1002/mabi.201500192  0.96
2015 Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-photon autofluorescence imaging of retinal structure and function in the living primate eye Proceedings of Frontiers in Optics 2015, Fio 2015 0.96
2014 Mustafi D, Kikano S, Palczewski K. Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes. Current Protocols in Mouse Biology. 4: 197-204. PMID 25621191 DOI: 10.1002/9780470942390.mo140169  0.96
2014 Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K. Human infrared vision is triggered by two-photon chromophore isomerization. Proceedings of the National Academy of Sciences of the United States of America. 111: E5445-54. PMID 25453064 DOI: 10.1073/pnas.1410162111  0.96
2014 Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR. Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Biomacromolecules. 15: 4570-8. PMID 25390360 DOI: 10.1021/bm501352s  0.96
2014 Palczewski K. Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Investigative Ophthalmology & Visual Science. 55: 6651-72. PMID 25338686 DOI: 10.1167/iovs.14-15502  0.96
2014 Park S, Li C, Haeseleer F, Palczewski K, Ames JB. Structural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4). The Journal of Biological Chemistry. 289: 31262-73. PMID 25258313 DOI: 10.1074/jbc.M114.604439  0.64
2014 Sundermeier TR, Jin H, Kleinjan ML, Mustafi D, Licatalosi DD, Palczewski K. Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina. Biochemistry. 53: 5831-3. PMID 25204418 DOI: 10.1021/bi500966b  0.96
2014 Yuan S, Filipek S, Palczewski K, Vogel H. Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Nature Communications. 5: 4733. PMID 25203160 DOI: 10.1038/ncomms5733  0.96
2014 Baker BY, Shi W, Wang B, Palczewski K. High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Science : a Publication of the Protein Society. 23: 1629-39. PMID 25176140 DOI: 10.1002/pro.2543  0.96
2014 Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K. Endogenous fluorophores enable two-photon imaging of the primate eye. Investigative Ophthalmology & Visual Science. 55: 4438-47. PMID 24970255 DOI: 10.1167/iovs.14-14395  0.64
2014 Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nature Medicine. 20: 785-9. PMID 24952647 DOI: 10.1038/nm.3590  0.64
2014 Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Molecular Pharmacology. 86: 231-42. PMID 24913940 DOI: 10.1124/mol.114.093070  0.96
2014 Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. STRA6 is critical for cellular vitamin A uptake and homeostasis. Human Molecular Genetics. 23: 5402-17. PMID 24852372 DOI: 10.1093/hmg/ddu258  0.96
2014 Comar WD, Schubert SM, Jastrzebska B, Palczewski K, Smith AW. Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes. Journal of the American Chemical Society. 136: 8342-9. PMID 24831851 DOI: 10.1021/ja501948w  0.96
2014 Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3780-91. PMID 24812086 DOI: 10.1096/fj.14-254292  0.96
2014 Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 111: E1428-37. PMID 24706832 DOI: 10.1073/pnas.1317986111  0.96
2014 Orban T, Jastrzebska B, Palczewski K. Structural approaches to understanding retinal proteins needed for vision. Current Opinion in Cell Biology. 27: 32-43. PMID 24680428 DOI: 10.1016/j.ceb.2013.11.001  0.96
2014 Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). The Journal of Biological Chemistry. 289: 12286-99. PMID 24648526 DOI: 10.1074/jbc.M114.552836  0.96
2014 Tsybovsky Y, Palczewski K. Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains. Protein Expression and Purification. 97: 50-60. PMID 24583180 DOI: 10.1016/j.pep.2014.02.010  0.96
2014 Wang B, Tsybovsky Y, Palczewski K, Chance MR. Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time. Journal of the American Society For Mass Spectrometry. 25: 729-41. PMID 24549892 DOI: 10.1007/s13361-013-0823-6  0.96
2014 Tu X, Palczewski K. The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. Journal of Structural Biology. 186: 86-94. PMID 24531000 DOI: 10.1016/j.jsb.2014.02.001  0.96
2014 Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K. R9AP overexpression alters phototransduction kinetics in iCre75 mice. Investigative Ophthalmology & Visual Science. 55: 1339-47. PMID 24526444 DOI: 10.1167/iovs.13-13564  0.96
2014 Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutant opsin. The Journal of Biological Chemistry. 289: 9288-303. PMID 24515108 DOI: 10.1074/jbc.M114.551713  0.96
2014 Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. Acs Nano. 8: 153-61. PMID 24350906 DOI: 10.1021/nn4054107  0.96
2014 Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity Journal of the American Chemical Society. 136: 137-146. PMID 24328211 DOI: 10.1021/ja411366w  0.96
2014 Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Human Molecular Genetics. 23: 1723-41. PMID 24214395 DOI: 10.1093/hmg/ddt561  0.96
2014 Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chemical Reviews. 114: 194-232. PMID 23905688 DOI: 10.1021/cr400107q  0.96
2013 Maeda A, Palczewski K. Retinal degeneration in animal models with a defective visual cycle. Drug Discovery Today. Disease Models. 10: e163-e172. PMID 25210527 DOI: 10.1016/j.ddmod.2014.01.001  0.96
2013 Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. The Journal of Clinical Investigation. 123: 5119-34. PMID 24231350 DOI: 10.1172/JCI69076  0.96
2013 Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. The Journal of Biological Chemistry. 288: 36272-84. PMID 24196967 DOI: 10.1074/jbc.M113.520700  0.96
2013 Salom D, Padayatti PS, Palczewski K. Crystallization of G protein-coupled receptors. Methods in Cell Biology. 117: 451-68. PMID 24143992 DOI: 10.1016/B978-0-12-408143-7.00024-4  0.96
2013 Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. The Journal of Biological Chemistry. 288: 34484-93. PMID 24129572 DOI: 10.1074/jbc.M113.518571  0.96
2013 Amengual J, Widjaja-Adhi MA, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J. Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. The Journal of Biological Chemistry. 288: 34081-96. PMID 24106281 DOI: 10.1074/jbc.M113.501049  0.96
2013 Du Y, Veenstra A, Palczewski K, Kern TS. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proceedings of the National Academy of Sciences of the United States of America. 110: 16586-91. PMID 24067647 DOI: 10.1073/pnas.1314575110  0.96
2013 Sharma R, Yin L, Geng Y, Merigan WH, Palczewska G, Palczewski K, Williams DR, Hunter JJ. In vivo two-photon imaging of the mouse retina. Biomedical Optics Express. 4: 1285-93. PMID 24009992 DOI: 10.1364/BOE.4.001285  0.96
2013 Helbling RE, Bolze CS, Golczak M, Palczewski K, Stocker A, Cascella M. Cellular retinaldehyde binding protein - Different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates Journal of Physical Chemistry B. 117: 10719-10729. PMID 23964907 DOI: 10.1021/jp405410t  0.96
2013 Mustafi D, Kevany BM, Genoud C, Bai X, Palczewski K. Photoreceptor phagocytosis is mediated by phosphoinositide signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4585-95. PMID 23913857 DOI: 10.1096/fj.13-237537  0.96
2013 Sui X, Kiser PD, Lintig Jv, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Archives of Biochemistry and Biophysics. 539: 203-13. PMID 23827316 DOI: 10.1016/j.abb.2013.06.012  0.96
2013 Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Archives of Biochemistry and Biophysics. 539: 214-22. PMID 23727499 DOI: 10.1016/j.abb.2013.05.007  0.96
2013 Palczewski K, Orban T. From atomic structures to neuronal functions of g protein-coupled receptors. Annual Review of Neuroscience. 36: 139-64. PMID 23682660 DOI: 10.1146/annurev-neuro-062012-170313  0.96
2013 Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science (New York, N.Y.). 340: 562-3. PMID 23641106 DOI: 10.1126/science.1238521  0.96
2013 Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. The Journal of Biological Chemistry. 288: 15326-41. PMID 23572532 DOI: 10.1074/jbc.M112.448712  0.96
2013 Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Human Molecular Genetics. 22: 2992-3002. PMID 23562822 DOI: 10.1093/hmg/ddt156  0.96
2013 Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure (London, England : 1993). 21: 854-60. PMID 23562398 DOI: 10.1016/j.str.2013.03.001  0.96
2013 Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. Plos One. 8: e58832. PMID 23555598 DOI: 10.1371/journal.pone.0058832  0.96
2013 Jastrzebska B, Ringler P, Palczewski K, Engel A. The rhodopsin-transducin complex houses two distinct rhodopsin molecules. Journal of Structural Biology. 182: 164-72. PMID 23458690 DOI: 10.1016/j.jsb.2013.02.014  0.96
2013 Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. The Journal of Biological Chemistry. 288: 10406-17. PMID 23426366 DOI: 10.1074/jbc.M112.443796  0.96
2013 Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Molecular & Cellular Proteomics : McP. 12: 1259-71. PMID 23378516 DOI: 10.1074/mcp.M112.025536  0.96
2013 Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods in Enzymology. 520: 239-56. PMID 23332703 DOI: 10.1016/B978-0-12-391861-1.00011-3  0.96
2013 Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1572-84. PMID 23303210 DOI: 10.1096/fj.12-225383  0.96
2013 Vahedi-Faridi A, Jastrzebska B, Palczewski K, Engel A. 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. Microscopy (Oxford, England). 62: 95-107. PMID 23267047 DOI: 10.1093/jmicro/dfs091  0.96
2013 Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Investigative Ophthalmology & Visual Science. 54: 455-66. PMID 23249702 DOI: 10.1167/iovs.12-11152  0.96
2013 Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. The Journal of Clinical Investigation. 123: 121-37. PMID 23221340 DOI: 10.1172/JCI66176  0.96
2013 Palczewska G, Palczewski K. Molecular imaging of the visual cycle Optics Infobase Conference Papers 0.96
2012 Latek D, Modzelewska A, Trzaskowski B, Palczewski K, Filipek S. G protein-coupled receptors--recent advances. Acta Biochimica Polonica. 59: 515-29. PMID 23251911  0.96
2012 Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proceedings of the National Academy of Sciences of the United States of America. 109: E2747-56. PMID 23012475 DOI: 10.1073/pnas.1212025109  0.96
2012 Gao SQ, Maeda T, Okano K, Palczewski K. A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Investigative Ophthalmology & Visual Science. 53: 6314-23. PMID 22918645 DOI: 10.1167/iovs.12-10279  0.96
2012 Tu X, Palczewski K. Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. Journal of Structural Biology. 180: 439-46. PMID 22892318 DOI: 10.1016/j.jsb.2012.07.011  0.96
2012 Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. Inflammatory priming predisposes mice to age-related retinal degeneration. The Journal of Clinical Investigation. 122: 2989-3001. PMID 22797304 DOI: 10.1172/JCI64427  0.96
2012 Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. The Journal of Biological Chemistry. 287: 29988-99. PMID 22761416 DOI: 10.1074/jbc.M112.351551  0.96
2012 Amengual J, Golczak M, Palczewski K, von Lintig J. Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. The Journal of Biological Chemistry. 287: 24216-27. PMID 22637576 DOI: 10.1074/jbc.M112.353979  0.96
2012 Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. The Journal of Biological Chemistry. 287: 23790-807. PMID 22605381 DOI: 10.1074/jbc.M112.361550  0.96
2012 Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K. Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure (London, England : 1993). 20: 826-40. PMID 22579250 DOI: 10.1016/j.str.2012.03.017  0.96
2012 Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. Melanopsin is highly resistant to light and chemical bleaching in vivo. The Journal of Biological Chemistry. 287: 20888-97. PMID 22547062 DOI: 10.1074/jbc.M111.325969  0.96
2012 Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K. Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1). Biochemistry. 51: 3404-11. PMID 22480180 DOI: 10.1021/bi300295y  0.96
2012 Sundermeier TR, Palczewski K. The physiological impact of microRNA gene regulation in the retina. Cellular and Molecular Life Sciences : Cmls. 69: 2739-50. PMID 22460583 DOI: 10.1007/s00018-012-0976-7  0.96
2012 Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. The Journal of Biological Chemistry. 287: 13356-70. PMID 22356908 DOI: 10.1074/jbc.M112.347518  0.96
2012 Padayatti P, Palczewska G, Sun W, Palczewski K, Salom D. Imaging of protein crystals with two-photon microscopy. Biochemistry. 51: 1625-37. PMID 22324807 DOI: 10.1021/bi201682q  0.56
2012 Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. Journal of Neurochemistry. 121: 146-56. PMID 22220722 DOI: 10.1111/j.1471-4159.2012.07647.x  0.96
2012 Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nature Chemical Biology. 8: 170-8. PMID 22198730 DOI: 10.1038/nchembio.759  0.96
2012 Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. The Journal of Biological Chemistry. 287: 5059-69. PMID 22184108 DOI: 10.1074/jbc.M111.315432  0.96
2012 Salom D, Wang B, Dong Z, Sun W, Padayatti P, Jordan S, Salon JA, Palczewski K. Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry. 51: 214-24. PMID 22145929 DOI: 10.1021/bi201707v  0.96
2012 Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 492-502. PMID 22090314 DOI: 10.1096/fj.11-197780  0.56
2011 Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. The Journal of Biological Chemistry. 286: 31749-60. PMID 21768104 DOI: 10.1074/jbc.M111.259028  0.96
2011 Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. The Journal of Biological Chemistry. 286: 15543-55. PMID 21383019 DOI: 10.1074/jbc.M111.228551  0.96
2010 Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nature Medicine. 16: 1444-9. PMID 21076393 DOI: 10.1038/nm.2260  0.96
2010 Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods in Molecular Biology (Clifton, N.J.). 652: 247-61. PMID 20552433 DOI: 10.1007/978-1-60327-325-1_14  1
2009 Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. The Journal of Biological Chemistry. 284: 18980-93. PMID 19423712 DOI: 10.1074/jbc.M109.003160  0.96
2009 Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Human Molecular Genetics. 18: 2748-60. PMID 19414487 DOI: 10.1093/hmg/ddp210  0.96
2008 Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. The Journal of Biological Chemistry. 283: 25091-102. PMID 18606814 DOI: 10.1074/jbc.M802981200  1
2008 Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metabolism. 7: 258-68. PMID 18316031 DOI: 10.1016/j.cmet.2008.01.009  0.96
2007 Moise AR, Golczak M, Imanishi Y, Palczewski K. Topology and membrane association of lecithin: retinol acyltransferase. The Journal of Biological Chemistry. 282: 2081-90. PMID 17114808 DOI: 10.1074/jbc.M608315200  1
2006 Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. The Journal of Biological Chemistry. 281: 37697-704. PMID 17032653 DOI: 10.1074/jbc.M608375200  0.96
2006 Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Molecular Pharmacology. 70: 1220-9. PMID 16837623 DOI: 10.1124/mol.106.026823  0.96
2006 Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. The Journal of Biological Chemistry. 281: 22289-98. PMID 16737970 DOI: 10.1074/jbc.M602664200  1
2006 Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 45: 4210-9. PMID 16566595 DOI: 10.1021/bi052382x  1
2005 Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. Plos Medicine. 2: e333. PMID 16250670 DOI: 10.1371/journal.pmed.0020333  0.96
2005 Golczak M, Imanishi Y, Kuksa V, Maeda T, Kubota R, Palczewski K. Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. The Journal of Biological Chemistry. 280: 42263-73. PMID 16216874 DOI: 10.1074/jbc.M509351200  1
2005 Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. The Journal of Biological Chemistry. 280: 18822-32. PMID 15755727 DOI: 10.1074/jbc.M501757200  0.96
2004 Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). Journal of Molecular Evolution. 59: 204-17. PMID 15486694 DOI: 10.1007/s00239-004-2614-y  0.96
2004 Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nature Neuroscience. 7: 1079-87. PMID 15452577 DOI: 10.1038/nn1320  0.96
2004 Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. The Journal of Biological Chemistry. 279: 50230-42. PMID 15358783 DOI: 10.1074/jbc.M409130200  1
2004 Mammen A, Simpson PJ, Mamman A, Simpson JP, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochemical and Biophysical Research Communications. 322: 1131-9. PMID 15336960 DOI: 10.1016/j.bbrc.2004.07.123  0.96
2004 Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. The Journal of Cell Biology. 166: 447-53. PMID 15314061 DOI: 10.1083/jcb.200405110  1
2004 Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. The Journal of Cell Biology. 164: 373-83. PMID 14745001 DOI: 10.1083/jcb.200311079  0.96
2004 Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. The Journal of Biological Chemistry. 279: 10422-32. PMID 14684738 DOI: 10.1074/jbc.M312410200  0.96
2003 Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Research. 43: 2959-81. PMID 14611933  1
2003 Maeda T, Imanishi Y, Palczewski K. Rhodopsin phosphorylation: 30 years later. Progress in Retinal and Eye Research. 22: 417-34. PMID 12742390  1
2003 Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. The Journal of Biological Chemistry. 278: 14442-50. PMID 12566452 DOI: 10.1074/jbc.M300087200  1
2002 Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. The Journal of Biological Chemistry. 277: 45537-46. PMID 12226107 DOI: 10.1074/jbc.M208882200  1
2002 Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. The European Journal of Neuroscience. 15: 63-78. PMID 11860507 DOI: 10.1046/j.0953-816x.2001.01835.x  0.96
2002 Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochemical and Biophysical Research Communications. 290: 615-23. PMID 11785943 DOI: 10.1006/bbrc.2001.6228  1
2001 Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. Gene transfer mediated by recombinant baculovirus into mouse eye. Investigative Ophthalmology & Visual Science. 42: 3294-300. PMID 11726636  1
2001 McBee JK, Van Hooser JP, Jang GF, Palczewski K. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. The Journal of Biological Chemistry. 276: 48483-93. PMID 11604395 DOI: 10.1074/jbc.M105840200  0.96
2001 Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. The Journal of Biological Chemistry. 276: 32456-65. PMID 11418621 DOI: 10.1074/jbc.M104949200  0.96
2001 McBee JK, Palczewski K, Baehr W, Pepperberg DR. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Progress in Retinal and Eye Research. 20: 469-529. PMID 11390257 DOI: 10.1016/S1350-9462(01)00002-7  0.96
2000 McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 39: 11370-80. PMID 10985782 DOI: 10.1021/bi001061c  0.96
2000 Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. The Journal of Biological Chemistry. 275: 28128-38. PMID 10871622 DOI: 10.1074/jbc.M004488200  0.96
1999 Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. A novel form of rhodopsin kinase from chicken retina and pineal gland. Febs Letters. 454: 115-21. PMID 10413107  0.64
1998 Zhao X, Huang J, Khani SC, Palczewski K. Molecular forms of human rhodopsin kinase (GRK1). The Journal of Biological Chemistry. 273: 5124-31. PMID 9478965  0.64
1998 Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proceedings of the National Academy of Sciences of the United States of America. 95: 328-33. PMID 9419375  0.64
1997 Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Visual Neuroscience. 14: 225-32. PMID 9147475  0.96
1996 Ohguro H, Rudnicka-Nawrot M, Buczyłko J, Zhao X, Taylor JA, Walsh KA, Palczewski K. Structural and enzymatic aspects of rhodopsin phosphorylation. The Journal of Biological Chemistry. 271: 5215-24. PMID 8617805 DOI: 10.1074/jbc.271.9.5215  0.96
1995 Zhao X, Palczewski K, Ohguro H. Mechanism of rhodopsin phosphorylation. Biophysical Chemistry. 56: 183-8. PMID 7662865  0.64
1994 Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. The Journal of Biological Chemistry. 269: 31080-9. PMID 7983048  0.96
1994 Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, Walsh KA, Gray-Keller MP, Detwiler PB, Baehr W. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein Neuron. 13: 395-404. PMID 7520254 DOI: 10.1016/0896-6273(94)90355-7  0.96
Show low-probability matches.