Krzysztof Palczewski - Publications

Affiliations: 
1997 Pharmacology University of Washington, Seattle, Seattle, WA 

213 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu JC, Lee JY, Ma X, ... ... Palczewski K, et al. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. Jci Insight. PMID 35015730 DOI: 10.1172/jci.insight.156301  0.359
2022 Du SW, Palczewski K. MicroRNA regulation of critical retinal pigment epithelial functions. Trends in Neurosciences. 45: 78-90. PMID 34753606 DOI: 10.1016/j.tins.2021.10.008  0.335
2021 Getter T, Kemp A, Vinberg F, Palczewski K. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. The Journal of Biological Chemistry. 297: 101401. PMID 34774799 DOI: 10.1016/j.jbc.2021.101401  0.335
2021 Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, et al. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Human Molecular Genetics. PMID 34726233 DOI: 10.1093/hmg/ddab316  0.769
2021 Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure (London, England : 1993). PMID 34678158 DOI: 10.1016/j.str.2021.10.002  0.815
2021 Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, ... Palczewski K, et al. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. The Journal of Cell Biology. 220. PMID 34132745 DOI: 10.1083/jcb.202101063  0.793
2021 Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. Journal of Medicinal Chemistry. PMID 34081480 DOI: 10.1021/acs.jmedchem.1c00279  0.779
2021 Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. . The Journal of Pharmacology and Experimental Therapeutics. PMID 33931547 DOI: 10.1124/jpet.120.000486  0.742
2021 Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Ramachandra Rao S, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. Jci Insight. PMID 33784255 DOI: 10.1172/jci.insight.146604  0.822
2021 Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjugate Chemistry. PMID 33677964 DOI: 10.1021/acs.bioconjchem.1c00043  0.32
2021 Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. The Journal of General Physiology. 153. PMID 33216847 DOI: 10.1085/jgp.202012675  0.789
2020 Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. The Journal of Biological Chemistry. 296: 100072. PMID 33434742 DOI: 10.1074/jbc.REV120.014405  0.389
2020 Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. The Journal of Biological Chemistry. PMID 33187985 DOI: 10.1074/jbc.REV120.014405  0.816
2020 Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature Biomedical Engineering. PMID 33122854 DOI: 10.1038/s41551-020-00652-2  0.762
2020 Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature Biomedical Engineering. PMID 33077938 DOI: 10.1038/s41551-020-00632-6  0.797
2020 Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 9. PMID 32960171 DOI: 10.7554/Elife.59422  0.365
2020 Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32860273 DOI: 10.1096/Fj.202000796Rr  0.8
2020 Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proceedings of the National Academy of Sciences of the United States of America. PMID 32759209 DOI: 10.1073/pnas.2008211117  0.811
2020 Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorganic & Medicinal Chemistry Letters. 30: 127421. PMID 32717613 DOI: 10.1016/J.Bmcl.2020.127421  0.325
2020 Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. Retinoids in the visual cycle: Role of the retinal G protein-coupled receptor. Journal of Lipid Research. PMID 32493732 DOI: 10.1194/Jlr.Tr120000850  0.84
2019 Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. The Journal of Biological Chemistry. PMID 31694912 DOI: 10.1074/Jbc.Ra119.011169  0.838
2019 Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Organic & Biomolecular Chemistry. PMID 31455964 DOI: 10.1039/C9Ob01645G  0.705
2019 Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900443RR. PMID 31121099 DOI: 10.1096/Fj.201900443Rr  0.456
2019 Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. The Journal of Biological Chemistry. PMID 31073029 DOI: 10.1074/Jbc.Ra119.008697  0.535
2019 Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Investigative Ophthalmology & Visual Science. 60: 1442-1453. PMID 30947334 DOI: 10.1167/Iovs.19-26560  0.787
2019 Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. The Journal of Biological Chemistry. PMID 30770468 DOI: 10.1074/Jbc.Ra119.007587  0.315
2019 Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802493R. PMID 30645148 DOI: 10.1096/Fj.201802493R  0.789
2018 Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801662R. PMID 30462532 DOI: 10.1096/Fj.201801662R  0.699
2018 Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-opsin exists in equilibrium between a predominant inactive and a rare highly active state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30459230 DOI: 10.1523/Jneurosci.1980-18.2018  0.332
2018 Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-retinaldehyde production in the classical visual cycle. The Biochemical Journal. 475: 3171-3188. PMID 30352831 DOI: 10.1042/Bcj20180193  0.812
2018 Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. Iscience. 4: 1-19. PMID 30240733 DOI: 10.1016/J.Isci.2018.05.001  0.327
2018 Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. Jci Insight. 3. PMID 30185665 DOI: 10.1172/Jci.Insight.121555  0.793
2018 Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective effect of a locked retinal chromophore analogue against light-induced retinal degeneration. Molecular Pharmacology. PMID 30018116 DOI: 10.1124/Mol.118.112581  0.38
2018 Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nature Communications. 9: 1996. PMID 29777099 DOI: 10.1038/S41467-018-04432-0  0.744
2018 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, ... ... Palczewski K, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nature Communications. 9: 1976. PMID 29773803 DOI: 10.1038/S41467-018-04261-1  0.555
2018 Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Human Molecular Genetics. PMID 29659842 DOI: 10.1093/Hmg/Ddy128  0.825
2018 Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. The Journal of General Physiology. PMID 29500274 DOI: 10.1085/Jgp.201711815  0.778
2018 Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan conjugates effectively deliver active chromophores to retinal photoreceptor cells in blind mice and dogs. Molecular Pharmacology. PMID 29453250 DOI: 10.1124/Mol.117.111294  0.372
2018 Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701250R. PMID 29401616 DOI: 10.1096/Fj.201701250R  0.307
2018 Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. PMID 29320632 DOI: 10.1021/Acs.Biochem.7B01118  0.336
2017 Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A therapeutic combination of GPCR modulators that protects photoreceptors from degeneration. The Journal of Pharmacology and Experimental Therapeutics. PMID 29162627 DOI: 10.1124/Jpet.117.245167  0.807
2017 Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Scientific Reports. 7: 14623. PMID 29116131 DOI: 10.1038/S41598-017-15191-1  0.304
2017 Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078372 DOI: 10.1073/Pnas.1712405114  0.339
2017 Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. The Journal of Biological Chemistry. PMID 28978645 DOI: 10.1074/Jbc.M117.812677  0.325
2017 Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Scientific Reports. 7: 2390. PMID 28539612 DOI: 10.1038/S41598-017-02549-8  0.339
2017 Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop G, Palczewski K, Hendrich MP, Kiser PD. Structure and spectroscopy of alkene-cleaving dioxygenases containing an atypically coordinated non-heme iron center. Biochemistry. PMID 28493664 DOI: 10.1021/Acs.Biochem.7B00251  0.729
2017 Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. The Journal of Biological Chemistry. PMID 28487362 DOI: 10.1074/Jbc.M117.780478  0.366
2017 Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational tuning of visual cycle modulator pharmacodynamics. The Journal of Pharmacology and Experimental Therapeutics. PMID 28476927 DOI: 10.1124/Jpet.117.240721  0.794
2017 Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28289214 DOI: 10.1073/Pnas.1617446114  0.796
2017 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, ... Palczewski K, et al. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics. PMID 28065882 DOI: 10.1093/Hmg/Ddw387  0.344
2016 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Human Molecular Genetics. 25: 4376-4388. PMID 28172828 DOI: 10.1093/Hmg/Ddw268  0.313
2016 Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annual Review of Vision Science. 2: 197-234. PMID 27917399 DOI: 10.1146/annurev-vision-111815-114407  0.787
2016 Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor tyrosine kinase MERTK is not required for transfer of bis-retinoids to the retinal pigmented epithelium. The Journal of Biological Chemistry. PMID 27875314 DOI: 10.1074/Jbc.M116.764563  0.328
2016 Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome Profiling of NIH3T3 Cell Lines Expressing Opsin and the P23H Opsin Mutant Identifies Candidate Drugs for the Treatment of Retinitis Pigmentosa. Pharmacological Research. PMID 27838510 DOI: 10.1016/J.Phrs.2016.10.031  0.514
2016 Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural insights into the Drosophila melanogaster retinol dehydrogenase, a member of the short-chain dehydrogenase/reductase family. Biochemistry. PMID 27809489 DOI: 10.1021/Acs.Biochem.6B00907  0.314
2016 Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacological Research. PMID 27720767 DOI: 10.1016/J.Phrs.2016.09.026  0.737
2016 Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Investigative Ophthalmology & Visual Science. 57: 4272-4281. PMID 27548901 DOI: 10.1167/Iovs.16-19415  0.322
2016 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Human Molecular Genetics. PMID 27506984 DOI: 10.1093/hmg/ddw268  0.313
2016 Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Science Signaling. 9: ra74. PMID 27460988 DOI: 10.1126/Scisignal.Aag0245  0.8
2016 Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key residues for catalytic function and metal coordination in a carotenoid cleavage dioxygenase. The Journal of Biological Chemistry. PMID 27453555 DOI: 10.1074/Jbc.M116.744912  0.751
2016 Sears AE, Palczewski K. Lecithin:retinol acyltransferase (LRAT): a key enzyme involved in the retinoid (visual) cycle. Biochemistry. PMID 27183166 DOI: 10.1021/Acs.Biochem.6B00319  0.34
2016 Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational change of human checkpoint kinase 1 (Chk1) induced by DNA damage. The Journal of Biological Chemistry. PMID 27129240 DOI: 10.1074/Jbc.M115.713248  0.74
2016 Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, ... ... Palczewski K, et al. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nature Chemical Biology. PMID 27110679 DOI: 10.1038/Nchembio.2069  0.619
2016 Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The biochemical basis of vitamin A3 production in arthropod vision. Acs Chemical Biology. PMID 26811964 DOI: 10.1021/Acschembio.5B00967  0.781
2016 Kaliszewski MJ, Comar WD, Skinner KC, Jastrzebska B, Palczewski K, Smith AW. Probing the Dimerization Affinity of Visual Opsins Biophysical Journal. 110: 592a-593a. DOI: 10.1016/J.Bpj.2015.11.3162  0.314
2015 Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. The Journal of Biological Chemistry. PMID 26499794 DOI: 10.1074/Jbc.M115.696799  0.748
2015 Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. The Journal of Biological Chemistry. PMID 26391396 DOI: 10.1074/Jbc.M115.682096  0.334
2015 Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. The Journal of Physiology. PMID 26350353 DOI: 10.1113/Jp271285  0.672
2015 Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. The Journal of Biological Chemistry. 290: 25728-44. PMID 26330551 DOI: 10.1074/Jbc.M115.662684  0.42
2015 Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opinion On Orphan Drugs. 3: 563-575. PMID 26246977 DOI: 10.1517/21678707.2015.1030393  0.301
2015 Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. The Journal of Clinical Investigation. 125: 2781-94. PMID 26075817 DOI: 10.1172/Jci80950  0.8
2015 Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nature Chemical Biology. 11: 409-15. PMID 25894083 DOI: 10.1038/Nchembio.1799  0.795
2015 Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Investigative Ophthalmology & Visual Science. 56: 2553-67. PMID 25783607 DOI: 10.1167/Iovs.14-16298  0.512
2015 Hofmann L, Palczewski K. The G protein-coupled receptor rhodopsin: a historical perspective. Methods in Molecular Biology (Clifton, N.J.). 1271: 3-18. PMID 25697513 DOI: 10.1007/978-1-4939-2330-4_1  0.372
2015 Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials. 44: 103-10. PMID 25617130 DOI: 10.1016/J.Biomaterials.2014.12.019  0.319
2015 Kevany BM, Zhang N, Jastrzebska B, Palczewski K. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Human Molecular Genetics. 24: 2627-40. PMID 25616964 DOI: 10.1093/Hmg/Ddv025  0.352
2015 Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Molecular Pharmacology. 87: 477-91. PMID 25538117 DOI: 10.1124/Mol.114.096560  0.365
2015 Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nature Chemical Biology. 11: 26-32. PMID 25383759 DOI: 10.1038/Nchembio.1687  0.763
2015 Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Molecular Neurobiology. 52: 679-95. PMID 25270370 DOI: 10.1007/S12035-014-8881-8  0.318
2014 Palczewski K. Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Investigative Ophthalmology & Visual Science. 55: 6651-72. PMID 25338686 DOI: 10.1167/Iovs.14-15502  0.385
2014 Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Molecular Pharmacology. 86: 231-42. PMID 24913940 DOI: 10.1124/Mol.114.093070  0.771
2014 Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3780-91. PMID 24812086 DOI: 10.1096/Fj.14-254292  0.3
2014 Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 111: E1428-37. PMID 24706832 DOI: 10.1073/Pnas.1317986111  0.358
2014 Orban T, Jastrzebska B, Palczewski K. Structural approaches to understanding retinal proteins needed for vision. Current Opinion in Cell Biology. 27: 32-43. PMID 24680428 DOI: 10.1016/J.Ceb.2013.11.001  0.316
2014 Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). The Journal of Biological Chemistry. 289: 12286-99. PMID 24648526 DOI: 10.1074/Jbc.M114.552836  0.791
2014 Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutant opsin. The Journal of Biological Chemistry. 289: 9288-303. PMID 24515108 DOI: 10.1074/Jbc.M114.551713  0.553
2014 Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity Journal of the American Chemical Society. 136: 137-146. PMID 24328211 DOI: 10.1021/Ja411366W  0.325
2014 Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Human Molecular Genetics. 23: 1723-41. PMID 24214395 DOI: 10.1093/Hmg/Ddt561  0.377
2014 Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chemical Reviews. 114: 194-232. PMID 23905688 DOI: 10.1021/Cr400107Q  0.81
2013 Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. The Journal of Biological Chemistry. 288: 36272-84. PMID 24196967 DOI: 10.1074/Jbc.M113.520700  0.309
2013 Sui X, Kiser PD, Lintig Jv, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Archives of Biochemistry and Biophysics. 539: 203-13. PMID 23827316 DOI: 10.1016/J.Abb.2013.06.012  0.758
2013 Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Archives of Biochemistry and Biophysics. 539: 214-22. PMID 23727499 DOI: 10.1016/J.Abb.2013.05.007  0.766
2013 Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science (New York, N.Y.). 340: 562-3. PMID 23641106 DOI: 10.1126/Science.1238521  0.73
2013 Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. The Journal of Biological Chemistry. 288: 15326-41. PMID 23572532 DOI: 10.1074/Jbc.M112.448712  0.325
2013 Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Human Molecular Genetics. 22: 2992-3002. PMID 23562822 DOI: 10.1093/Hmg/Ddt156  0.325
2013 Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1572-84. PMID 23303210 DOI: 10.1096/Fj.12-225383  0.3
2013 Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Investigative Ophthalmology & Visual Science. 54: 455-66. PMID 23249702 DOI: 10.1167/Iovs.12-11152  0.31
2013 Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. The Journal of Clinical Investigation. 123: 121-37. PMID 23221340 DOI: 10.1172/Jci66176  0.374
2013 Palczewska G, Palczewski K. Molecular imaging of the visual cycle Optics Infobase Conference Papers. DOI: 10.1364/Fio.2013.Ftu4I.1  0.357
2012 Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proceedings of the National Academy of Sciences of the United States of America. 109: E2747-56. PMID 23012475 DOI: 10.1073/Pnas.1212025109  0.754
2012 Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. The Journal of Biological Chemistry. 287: 23790-807. PMID 22605381 DOI: 10.1074/Jbc.M112.361550  0.755
2012 Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. Melanopsin is highly resistant to light and chemical bleaching in vivo. The Journal of Biological Chemistry. 287: 20888-97. PMID 22547062 DOI: 10.1074/Jbc.M111.325969  0.359
2012 Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. The Journal of Biological Chemistry. 287: 13356-70. PMID 22356908 DOI: 10.1074/Jbc.M112.347518  0.776
2012 Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. Journal of Neurochemistry. 121: 146-56. PMID 22220722 DOI: 10.1111/J.1471-4159.2012.07647.X  0.34
2012 Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nature Chemical Biology. 8: 170-8. PMID 22198730 DOI: 10.1038/Nchembio.759  0.333
2012 Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. The Journal of Biological Chemistry. 287: 5059-69. PMID 22184108 DOI: 10.1074/Jbc.M111.315432  0.327
2012 Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochimica Et Biophysica Acta. 1821: 137-51. PMID 21447403 DOI: 10.1016/J.Bbalip.2011.03.005  0.809
2011 Palczewski K. Thematic minireview series on focus on vision. The Journal of Biological Chemistry. 287: 1610-1. PMID 22074916 DOI: 10.1074/Jbc.R111.322347  0.389
2011 Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 50: 6855-66. PMID 21721517 DOI: 10.1021/Bi200774W  0.312
2011 Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3157-76. PMID 21659555 DOI: 10.1096/Fj.11-186767  0.353
2011 Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. Journal of Neuroscience Methods. 198: 70-6. PMID 21439323 DOI: 10.1016/J.Jneumeth.2011.03.013  0.324
2010 Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nature Medicine. 16: 1444-9. PMID 21076393 DOI: 10.1038/Nm.2260  0.675
2010 Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Archives of Ophthalmology (Chicago, Ill. : 1960). 128: 1483-5. PMID 21060052 DOI: 10.1001/Archophthalmol.2010.245  0.314
2010 Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods in Molecular Biology (Clifton, N.J.). 652: 247-61. PMID 20552433 DOI: 10.1007/978-1-60327-325-1_14  0.706
2010 Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods in Molecular Biology (Clifton, N.J.). 652: 229-45. PMID 20552432 DOI: 10.1007/978-1-60327-325-1_13  0.329
2010 Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proceedings of the National Academy of Sciences of the United States of America. 107: 8428-33. PMID 20404157 DOI: 10.1073/Pnas.1000640107  0.377
2010 Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Progress in Retinal and Eye Research. 29: 428-42. PMID 20304090 DOI: 10.1016/J.Preteyeres.2010.03.002  0.791
2010 von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 35: 400-10. PMID 20188572 DOI: 10.1016/J.Tibs.2010.01.005  0.761
2010 Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda, Md.). 25: 8-15. PMID 20134024 DOI: 10.1152/Physiol.00038.2009  0.31
2010 Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. The Journal of Biological Chemistry. 285: 9667-82. PMID 20100834 DOI: 10.1074/Jbc.M109.063941  0.798
2010 Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. The Journal of Biological Chemistry. 285: 1899-908. PMID 19901021 DOI: 10.1074/Jbc.M109.061713  0.782
2009 Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 967-71. PMID 19851000 DOI: 10.1107/S1744309109032928  0.741
2009 Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proceedings of the National Academy of Sciences of the United States of America. 106: 17325-30. PMID 19805034 DOI: 10.1073/Pnas.0906600106  0.809
2009 Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Investigative Ophthalmology & Visual Science. 50: 5435-43. PMID 19553623 DOI: 10.1167/Iovs.09-3944  0.319
2009 Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. The Journal of Biological Chemistry. 284: 18980-93. PMID 19423712 DOI: 10.1074/Jbc.M109.003160  0.609
2009 Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Human Molecular Genetics. 18: 2748-60. PMID 19414487 DOI: 10.1093/Hmg/Ddp210  0.598
2009 Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 48: 4294-304. PMID 19348429 DOI: 10.1021/Bi900417B  0.324
2009 Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. The Journal of Biological Chemistry. 284: 15173-83. PMID 19304658 DOI: 10.1074/Jbc.M900322200  0.362
2009 Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochemistry and Photobiology. 85: 425-30. PMID 19192200 DOI: 10.1111/J.1751-1097.2008.00516.X  0.34
2009 Provasi D, Palczewski K, Filizola M. Exploring the Thermodynamics of Activation Pathways of Bovine Rhodopsin with Fast Molecular Dynamics Simulations Biophysical Journal. 96: 679a. DOI: 10.1016/J.Bpj.2008.12.3586  0.332
2009 Gupta S, Angel T, Jastrzebska B, Palczewski K, Chance MR. X-ray Footprinting Studies on Photoactivation of Bovine Rhodopsin Biophysical Journal. 96: 195a. DOI: 10.1016/J.Bpj.2008.12.1047  0.305
2008 Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 47: 13296-307. PMID 19053287 DOI: 10.1021/Bi8018527  0.325
2008 Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 47: 9856-65. PMID 18722466 DOI: 10.1021/Bi800905V  0.784
2008 Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. The Journal of Biological Chemistry. 283: 26684-93. PMID 18658157 DOI: 10.1074/Jbc.M804505200  0.368
2008 Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. The Journal of Biological Chemistry. 283: 25091-102. PMID 18606814 DOI: 10.1074/Jbc.M802981200  0.693
2008 Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4008-14. PMID 18400900 DOI: 10.1523/Jneurosci.0317-08.2008  0.303
2008 Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metabolism. 7: 258-68. PMID 18316031 DOI: 10.1016/J.Cmet.2008.01.009  0.642
2008 Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. The Journal of Biological Chemistry. 283: 9543-54. PMID 18195010 DOI: 10.1074/Jbc.M708982200  0.806
2008 Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. Journal of the American Chemical Society. 130: 1154-5. PMID 18179220 DOI: 10.1021/Ja710487Q  0.751
2007 Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proceedings of the National Academy of Sciences of the United States of America. 104: 19565-70. PMID 18048336 DOI: 10.1073/Pnas.0707477104  0.378
2007 Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. The European Journal of Neuroscience. 26: 1940-9. PMID 17868371 DOI: 10.1111/J.1460-9568.2007.05801.X  0.335
2007 Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Human cone photoreceptor dependence on RPE65 isomerase. Proceedings of the National Academy of Sciences of the United States of America. 104: 15123-8. PMID 17848510 DOI: 10.1073/Pnas.0706367104  0.334
2007 Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 46: 8350-9. PMID 17580959 DOI: 10.1021/Bi700154H  0.333
2007 Kiser PD, Lodowski DT, Palczewski K. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 457-61. PMID 17554162 DOI: 10.1107/S1744309107020295  0.74
2007 Ridge KD, Palczewski K. Visual rhodopsin sees the light: Structure and mechanism of G protein signaling Journal of Biological Chemistry. 282: 9297-9301. PMID 17289671 DOI: 10.1074/Jbc.R600032200  0.343
2007 Moise AR, Golczak M, Imanishi Y, Palczewski K. Topology and membrane association of lecithin: retinol acyltransferase. The Journal of Biological Chemistry. 282: 2081-90. PMID 17114808 DOI: 10.1074/Jbc.M608315200  0.636
2006 Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. The Journal of Biological Chemistry. 281: 37697-704. PMID 17032653 DOI: 10.1074/Jbc.M608375200  0.713
2006 Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Investigative Ophthalmology & Visual Science. 47: 4540-6. PMID 17003450 DOI: 10.1167/Iovs.06-0215  0.321
2006 Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Molecular Pharmacology. 70: 1220-9. PMID 16837623 DOI: 10.1124/Mol.106.026823  0.715
2006 Tu DC, Owens LA, Anderson L, Golczak M, Doyle SE, McCall M, Menaker M, Palczewski K, Van Gelder RN. Inner retinal photoreception independent of the visual retinoid cycle. Proceedings of the National Academy of Sciences of the United States of America. 103: 10426-31. PMID 16788071 DOI: 10.1073/Pnas.0600917103  0.309
2006 Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. The Journal of Biological Chemistry. 281: 22289-98. PMID 16737970 DOI: 10.1074/Jbc.M602664200  0.707
2006 Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. Plos Medicine. 3: e201. PMID 16700630 DOI: 10.1371/Journal.Pmed.0030201  0.316
2006 Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 45: 4210-9. PMID 16566595 DOI: 10.1021/Bi052382X  0.704
2005 Zhang L, Salom D, He J, Okun A, Ballesteros J, Palczewski K, Li N. Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry. 44: 14509-18. PMID 16262251 DOI: 10.1021/Bi051386Z  0.348
2005 Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. Plos Medicine. 2: e333. PMID 16250670 DOI: 10.1371/Journal.Pmed.0020333  0.693
2005 Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 1072-82. PMID 16226919 DOI: 10.1016/J.Ymthe.2005.08.008  0.326
2005 Golczak M, Imanishi Y, Kuksa V, Maeda T, Kubota R, Palczewski K. Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. The Journal of Biological Chemistry. 280: 42263-73. PMID 16216874 DOI: 10.1074/Jbc.M509351200  0.67
2005 Bartl FJ, Fritze O, Ritter E, Herrmann R, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. The Journal of Biological Chemistry. 280: 34259-67. PMID 16027155 DOI: 10.1074/Jbc.M505260200  0.328
2005 Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J. Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proceedings of the National Academy of Sciences of the United States of America. 102: 6177-82. PMID 15837919 DOI: 10.1073/Pnas.0500646102  0.356
2005 Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. The Journal of Biological Chemistry. 280: 18822-32. PMID 15755727 DOI: 10.1074/Jbc.M501757200  0.726
2005 Mammen A, Simpson PJ, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Corrigendum to “Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling” [Biochem. Biophys. Res. Commun. 322 (2004) 1131–1139] Biochemical and Biophysical Research Communications. 326: 695. DOI: 10.1016/J.Bbrc.2004.11.082  0.607
2004 Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). Journal of Molecular Evolution. 59: 204-17. PMID 15486694 DOI: 10.1007/S00239-004-2614-Y  0.671
2004 Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. The Journal of Biological Chemistry. 279: 53828-39. PMID 15459196 DOI: 10.1074/Jbc.M408472200  0.369
2004 Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nature Neuroscience. 7: 1079-87. PMID 15452577 DOI: 10.1038/Nn1320  0.657
2004 Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. The Journal of Biological Chemistry. 279: 50230-42. PMID 15358783 DOI: 10.1074/Jbc.M409130200  0.642
2004 Mammen A, Simpson PJ, Mamman A, Simpson JP, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochemical and Biophysical Research Communications. 322: 1131-9. PMID 15336960 DOI: 10.1016/J.Bbrc.2004.07.123  0.603
2004 Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. The Journal of Cell Biology. 166: 447-53. PMID 15314061 DOI: 10.1083/Jcb.200405110  0.645
2004 Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. The Journal of Cell Biology. 164: 373-83. PMID 14745001 DOI: 10.1083/Jcb.200311079  0.717
2004 Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. The Journal of Biological Chemistry. 279: 10422-32. PMID 14684738 DOI: 10.1074/Jbc.M312410200  0.716
2003 Teller DC, Stenkamp RE, Palczewski K. Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. Febs Letters. 555: 151-9. PMID 14630336 DOI: 10.1016/S0014-5793(03)01152-9  0.301
2003 Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Research. 43: 2959-81. PMID 14611933 DOI: 10.1016/S0042-6989(03)00482-6  0.698
2003 Maeda T, Imanishi Y, Palczewski K. Rhodopsin phosphorylation: 30 years later. Progress in Retinal and Eye Research. 22: 417-34. PMID 12742390 DOI: 10.1016/S1350-9462(03)00017-X  0.687
2003 Schadel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP. Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. The Journal of Biological Chemistry. 278: 24896-903. PMID 12707280 DOI: 10.1074/Jbc.M302115200  0.337
2003 Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. The Journal of Biological Chemistry. 278: 14442-50. PMID 12566452 DOI: 10.1074/Jbc.M300087200  0.711
2003 Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature. 421: 127-8. PMID 12520290 DOI: 10.1038/421127A  0.301
2003 Filipek S, Stenkamp RE, Teller DC, Palczewski K. G protein-coupled receptor rhodopsin: a prospectus. Annual Review of Physiology. 65: 851-79. PMID 12471166 DOI: 10.1146/Annurev.Physiol.65.092101.142611  0.357
2003 Heck M, Schädel SA, Maretzki D, Bartl FJ, Ritter E, Palczewski K, Hofmann KP. Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. The Journal of Biological Chemistry. 278: 3162-9. PMID 12427735 DOI: 10.1074/Jbc.M209675200  0.327
2002 Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. The Journal of Biological Chemistry. 277: 45537-46. PMID 12226107 DOI: 10.1074/Jbc.M208882200  0.71
2002 Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. Recovery of visual functions in a mouse model of Leber congenital amaurosis. The Journal of Biological Chemistry. 277: 19173-82. PMID 11897783 DOI: 10.1074/Jbc.M112384200  0.388
2002 Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. The European Journal of Neuroscience. 15: 63-78. PMID 11860507 DOI: 10.1046/J.0953-816X.2001.01835.X  0.68
2002 Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochemical and Biophysical Research Communications. 290: 615-23. PMID 11785943 DOI: 10.1006/Bbrc.2001.6228  0.634
2001 Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. Gene transfer mediated by recombinant baculovirus into mouse eye. Investigative Ophthalmology & Visual Science. 42: 3294-300. PMID 11726636  0.586
2001 McBee JK, Van Hooser JP, Jang GF, Palczewski K. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. The Journal of Biological Chemistry. 276: 48483-93. PMID 11604395 DOI: 10.1074/Jbc.M105840200  0.829
2001 Okada T, Palczewski K. Crystal structure of rhodopsin: implications for vision and beyond Current Opinion in Structural Biology. 11: 420-426. PMID 11495733 DOI: 10.1016/S0959-440X(00)00227-X  0.372
2001 Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. The Journal of Biological Chemistry. 276: 32456-65. PMID 11418621 DOI: 10.1074/Jbc.M104949200  0.82
2001 McBee JK, Palczewski K, Baehr W, Pepperberg DR. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Progress in Retinal and Eye Research. 20: 469-529. PMID 11390257 DOI: 10.1016/S1350-9462(01)00002-7  0.841
2000 Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CL, Marmor MF, Jacobson SG, Palczewski K. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Visual Neuroscience. 17: 667-78. PMID 11153648 DOI: 10.1017/S0952523800175029  0.34
2000 Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 39: 15225-15233. PMID 11106502 DOI: 10.1021/Bi0018685  0.528
2000 McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 39: 11370-80. PMID 10985782 DOI: 10.1021/Bi001061C  0.834
2000 Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. The Journal of Biological Chemistry. 275: 28128-38. PMID 10871622 DOI: 10.1074/Jbc.M004488200  0.832
2000 Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proceedings of the National Academy of Sciences of the United States of America. 97: 8623-8. PMID 10869443 DOI: 10.1073/Pnas.150236297  0.365
2000 Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases Methods in Enzymology. 316: 359-371. PMID 10800687 DOI: 10.1016/S0076-6879(00)16735-7  0.322
2000 Stecher H, Palczewski K. Multienzyme analysis of visual cycle. Methods in Enzymology. 316: 330-44. PMID 10800685 DOI: 10.1016/S0076-6879(00)16733-3  0.358
1999 Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. A novel form of rhodopsin kinase from chicken retina and pineal gland. Febs Letters. 454: 115-21. PMID 10413107 DOI: 10.1016/S0014-5793(99)00764-4  0.586
1999 Stecher H, Gelb MH, Saari JC, Palczewski K. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. The Journal of Biological Chemistry. 274: 8577-85. PMID 10085092 DOI: 10.1074/Jbc.274.13.8577  0.325
1998 Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. The Journal of Biological Chemistry. 273: 21790-9. PMID 9705317 DOI: 10.1074/Jbc.273.34.21790  0.365
1998 Zhao X, Huang J, Khani SC, Palczewski K. Molecular forms of human rhodopsin kinase (GRK1). The Journal of Biological Chemistry. 273: 5124-31. PMID 9478965 DOI: 10.1074/Jbc.273.9.5124  0.603
1998 Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proceedings of the National Academy of Sciences of the United States of America. 95: 1271-6. PMID 9448321 DOI: 10.1073/Pnas.95.3.1271  0.349
1998 Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proceedings of the National Academy of Sciences of the United States of America. 95: 328-33. PMID 9419375 DOI: 10.1073/Pnas.95.1.328  0.608
1997 Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Visual Neuroscience. 14: 225-32. PMID 9147475 DOI: 10.1017/S0952523800011366  0.596
1996 Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W. Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. Febs Letters. 385: 47-52. PMID 8641465 DOI: 10.1016/0014-5793(96)00345-6  0.314
1996 Ohguro H, Rudnicka-Nawrot M, Buczyłko J, Zhao X, Taylor JA, Walsh KA, Palczewski K. Structural and enzymatic aspects of rhodopsin phosphorylation. The Journal of Biological Chemistry. 271: 5215-24. PMID 8617805 DOI: 10.1074/Jbc.271.9.5215  0.506
1996 Jäger S, Palczewski K, Hofmann KP. Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry. 35: 2901-2908. PMID 8608127 DOI: 10.1021/Bi9524068  0.358
1995 Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K. Guanylyl cyclase activating protein: A calcium-sensitive regulator of phototransduction Journal of Biological Chemistry. 270: 22029-22036. PMID 7665624 DOI: 10.1074/Jbc.270.37.22029  0.333
1995 Zhao X, Palczewski K, Ohguro H. Mechanism of rhodopsin phosphorylation. Biophysical Chemistry. 56: 183-8. PMID 7662865 DOI: 10.1016/0301-4622(95)00031-R  0.549
1994 Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. The Journal of Biological Chemistry. 269: 31080-9. PMID 7983048  0.551
1994 Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, Walsh KA, Gray-Keller MP, Detwiler PB, Baehr W. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein Neuron. 13: 395-404. PMID 7520254 DOI: 10.1016/0896-6273(94)90355-7  0.537
1994 Gorczyca WA, Hooser JPV, Palczewski K. Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry. 33: 3217-3222. PMID 7511001 DOI: 10.1021/Bi00177A011  0.312
1993 Buczyłko J, Palczewski K. Purification of Arrestin from Bovine Retinas Methods in Neurosciences. 15: 226-236. DOI: 10.1016/B978-0-12-185279-5.50021-2  0.325
1993 Palczewski K. Purification of Rhodopsin Kinase from Bovine Rod Outer Segments Methods in Neurosciences. 15: 217-225. DOI: 10.1016/B978-0-12-185279-5.50020-0  0.301
1992 Palczewski K, Rispoli G, Detwiler PB. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 8: 117-26. PMID 1309646 DOI: 10.1016/0896-6273(92)90113-R  0.312
1991 Polans AS, Buczyłko J, Crabb J, Palczewski K. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy Journal of Cell Biology. 112: 981-989. PMID 1999465 DOI: 10.1083/Jcb.112.5.981  0.336
1990 Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 29: 10102-10106. PMID 2271641 DOI: 10.1021/Bi00495A013  0.305
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