Tony Yaksh - Publications

University of California, San Diego, La Jolla, CA 
pain, pharmacology

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Moreno AM, Alemán F, Catroli GF, Hunt M, Hu M, Dailamy A, Pla A, Woller SA, Palmer N, Parekh U, McDonald D, Roberts AJ, Goodwill V, Dryden I, Hevner RF, ... ... Yaksh TL, et al. Long-lasting analgesia via targeted in situ repression of Na1.7 in mice. Science Translational Medicine. 13. PMID 33692134 DOI: 10.1126/scitranslmed.aay9056  0.731
2020 Gonçalves Dos Santos G, Jimenéz-Andrade JM, Woller SA, Muñoz-Islas E, Ramírez-Rosas MB, Ohashi N, Ferreira Catroli G, Fujita Y, Yaksh TL, Corr M. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Scientific Reports. 10: 15596. PMID 32973194 DOI: 10.1038/s41598-020-72441-5  0.719
2019 Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. Nerve-growth-factor antibody for the treatment of osteoarthritis pain and chronic low back pain: mechanism of action in the context of efficacy and safety. Pain. PMID 31145219 DOI: 10.1097/J.Pain.0000000000001625  0.38
2018 Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Materials Today (Kidlington, England). 21: 951-959. PMID 31156331 DOI: 10.1016/J.Mattod.2018.04.001  0.667
2018 Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Dos Santos GG, Yaksh TL, Corr M. Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice. Brain, Behavior, and Immunity. PMID 30465880 DOI: 10.1016/j.bbi.2018.11.014  0.721
2018 Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats. Pain. PMID 30130298 DOI: 10.1097/J.Pain.0000000000001373  0.326
2018 Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. Targeting Toll-like Receptor-4 (TLR4) - Emerging Therapeutic Target for Persistent Pain States. Pain. PMID 29889119 DOI: 10.1097/j.pain.0000000000001306  0.725
2018 Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Reports. 23: 2667-2677. PMID 29847797 DOI: 10.1016/j.celrep.2018.04.110  0.733
2018 Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, ... Yaksh TL, et al. Transition to chronic pain: opportunities for novel therapeutics. Nature Reviews. Neuroscience. PMID 29765159 DOI: 10.1038/S41583-018-0012-5  0.484
2018 Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clinical and Experimental Rheumatology. 36: 172. PMID 29461960  0.668
2018 Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Seminars in Immunopathology. PMID 29423889 DOI: 10.1007/s00281-017-0669-2  0.74
2018 Woller S, Corr M, Miller Y, Yaksh T. Intrathecal administration of AIBP prevents and reverses pain states The Journal of Pain. 19: S83. DOI: 10.1016/J.Jpain.2017.12.202  0.73
2017 Christianson C, BalkisBas D, Holmdahl R, Selva NK, Yaksh T, Corr M, Firestein G, Svensson CI. Pain mechanisms in animal models of rheumatoid arthritis. Scandinavian Journal of Pain. 1: 168-169. PMID 29913950 DOI: 10.1016/J.Sjpain.2010.05.006  0.594
2017 Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clinical and Experimental Rheumatology. 35: 40-46. PMID 28967373  0.732
2017 Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 76-85. PMID 28903493 DOI: 10.1093/Toxsci/Kfx118  0.31
2017 Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scandinavian Journal of Pain. 16: 1-9. PMID 28850381 DOI: 10.1016/J.Sjpain.2016.12.008  0.578
2017 Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Molecular Pain. 13: 1744806917703112. PMID 28394696 DOI: 10.1177/1744806917703112  0.363
2016 Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scandinavian Journal of Pain. 10: 90-102. PMID 28361779 DOI: 10.1016/J.Sjpain.2015.10.006  0.573
2016 Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. Effects of intraplantar Botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. The European Journal of Neuroscience. PMID 27108664 DOI: 10.1111/Ejn.13261  0.591
2016 Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Rivkah Isseroff R, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain, Behavior, and Immunity. PMID 27044335 DOI: 10.1016/j.bbi.2016.03.026  0.731
2016 Rijsdijk M, Svensson CI, Wijck AJv, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models Scandinavian Journal of Pain. 10: 90-102. DOI: 10.1016/j.sjpain.2015.10.006  0.558
2016 Woller S, Yaksh T, Corr M. (311) Persistent post-inflammatory mechanical allodynia in male arthritic mice: contribution of TNF and IFNβ The Journal of Pain. 17: S53. DOI: 10.1016/J.Jpain.2016.01.218  0.709
2015 Park HJ, Sandor K, McQueen J, Woller SA, Svensson CI, Corr M, Yaksh TL. The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. European Journal of Pain (London, England). PMID 26517300 DOI: 10.1002/Ejp.816  0.732
2015 Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. The search for novel analgesics: targets and mechanisms. F1000prime Reports. 7: 56. PMID 26097729 DOI: 10.12703/P7-56  0.765
2015 Woller SA, Corr M, Yaksh TL. Differences in cisplatin-induced mechanical allodynia in male and female mice. European Journal of Pain (London, England). PMID 25716290 DOI: 10.1002/ejp.679  0.705
2015 Bas DB, Abdelmoaty S, Sandor K, Codeluppi S, Fitzsimmons B, Steinauer J, Hua XY, Yaksh TL, Svensson CI. Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. European Journal of Pain (London, England). 19: 260-70. PMID 24942612 DOI: 10.1002/Ejp.544  0.576
2015 Woller S, Ocheltree C, Yaksh T, Corr M. (281) Characterization of Toll-like receptor signaling in pain and arthritis in female mice The Journal of Pain. 16: S46. DOI: 10.1016/J.Jpain.2015.01.199  0.735
2014 Leung A, Shukla S, Li E, Duann JR, Yaksh T. Supraspinal characterization of the thermal grill illusion with fMRI. Molecular Pain. 10: 18. PMID 24612493 DOI: 10.1186/1744-8069-10-18  0.329
2014 Park HJ, Stokes JA, Corr M, Yaksh TL. Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice. Cancer Chemotherapy and Pharmacology. 73: 25-34. PMID 24162377 DOI: 10.1007/S00280-013-2304-9  0.672
2014 Woller S, Corr M, Yaksh T. (298) Toll-like receptors in cisplatin-induced neuropathy in male and female mice The Journal of Pain. 15: S50. DOI: 10.1016/J.Jpain.2014.01.208  0.704
2013 Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. Journal of Neuroinflammation. 10: 148. PMID 24321498 DOI: 10.1186/1742-2094-10-148  0.706
2013 Nizet V, Yaksh T. Neuroscience: Bacteria get on your nerves. Nature. 501: 43-4. PMID 23965630 DOI: 10.1038/Nature12550  0.364
2013 Stokes JA, Corr M, Yaksh TL. Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ. Pain. 154: 733-42. PMID 23489833 DOI: 10.1016/J.Pain.2013.01.012  0.68
2013 Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesthesia and Analgesia. 116: 224-31. PMID 23223118 DOI: 10.1213/Ane.0B013E31826E1007  0.697
2012 Lampa J, Westman M, Kadetoff D, Agréus AN, Le Maître E, Gillis-Haegerstrand C, Andersson M, Khademi M, Corr M, Christianson CA, Delaney A, Yaksh TL, Kosek E, Svensson CI. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 12728-33. PMID 22802629 DOI: 10.1073/Pnas.1118748109  0.499
2012 Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation : Journal of the International Neuromodulation Society. 15: 436-64; discussion 4. PMID 22748024 DOI: 10.1111/j.1525-1403.2012.00476.x  0.345
2012 Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: consensus on diagnosis, detection, and treatment of catheter-tip granulomas (inflammatory masses). Neuromodulation : Journal of the International Neuromodulation Society. 15: 483-95; discussion 4. PMID 22494332 DOI: 10.1111/j.1525-1403.2012.00449.x  0.327
2012 Christianson CA, Corr M, Yaksh TL, Svensson CI. K/BxN serum transfer arthritis as a model of inflammatory joint pain. Methods in Molecular Biology (Clifton, N.J.). 851: 249-60. PMID 22351097 DOI: 10.1007/978-1-61779-561-9_19  0.548
2012 Mamet J, Klukinov M, Yaksh T, Malkmus S, Williams S, Taylor B, Donahue R, Porreca F, Xie J, Oyarzo J, Brennan T, Subieta A, Harris S, Schmidt W, Yeomans D. AYX1 DNA-decoy compound prevents the maintenance of pain after incisional, inflammatory or neuropathic injury The Journal of Pain. 13: S71. DOI: 10.1016/J.Jpain.2012.01.297  0.342
2011 Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 152: 2881-91. PMID 22019135 DOI: 10.1016/J.Pain.2011.09.020  0.76
2011 Stokes JA, Corr M, Yaksh TL. Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. Neuroscience Letters. 504: 215-8. PMID 21964382 DOI: 10.1016/J.Neulet.2011.09.025  0.693
2011 Xu Q, Yaksh TL. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Current Opinion in Anaesthesiology. 24: 400-7. PMID 21659872 DOI: 10.1097/ACO.0b013e32834871df  0.301
2010 Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 151: 394-403. PMID 20739123 DOI: 10.1016/J.Pain.2010.07.030  0.586
2010 Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. British Journal of Pharmacology. 160: 1754-64. PMID 20649577 DOI: 10.1111/j.1476-5381.2010.00811.x  0.573
2010 Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesthesia and Analgesia. 111: 554-60. PMID 20610553 DOI: 10.1213/Ane.0B013E3181E3A2A2  0.557
2010 Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. Journal of Neurochemistry. 114: 981-93. PMID 20492349 DOI: 10.1111/J.1471-4159.2010.06815.X  0.578
2010 Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 112: 1216-24. PMID 20395821 DOI: 10.1097/Aln.0B013E3181D94D8B  0.341
2010 Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 21: 313-7. PMID 20134354 DOI: 10.1097/Wnr.0B013E32833774Bf  0.58
2010 Christianson CA, Corr M, Firestein GS, Yaksh TL, Svensson CI. Persistent tactile allodynia and spinal glia activation in the K/BxN serum transfer arthritis model Annals of the Rheumatic Diseases. 69: A53-A54. DOI: 10.1136/Ard.2010.129643L  0.561
2009 Sorkin LS, Yaksh TL. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 609-19. PMID 19789066 DOI: 10.1016/j.nurt.2009.07.007  0.585
2009 Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 136: 1339-48, e1-2. PMID 19249394 DOI: 10.1053/J.Gastro.2008.12.044  0.555
2009 Buczynski M, Dumlao D, Svensson C, Shim J, Fitzsimmons B, Dennis E, Yaksh T, Hua X. Peripheral inflammation-induced spinal eicosanoids: effects of morphine, ketorolac and NDGA The Journal of Pain. 10: S32. DOI: 10.1016/J.Jpain.2009.01.137  0.612
2008 Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 139: 569-77. PMID 18692315 DOI: 10.1016/j.pain.2008.06.014  0.528
2008 Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacology, Biochemistry, and Behavior. 90: 664-75. PMID 18584857 DOI: 10.1016/J.Pbb.2008.05.016  0.558
2008 Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL. Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience. 154: 1077-87. PMID 18511207 DOI: 10.1016/J.Neuroscience.2008.04.033  0.584
2008 Bradesi S, Svensson CI, Pothoulakis C, Yaksh TL, Mayer EA. T1450 Glucocorticoids Mediate Spinal Microglia Activation and Visceral Hyperalgesia in a Rat Model of Chronic Stress Gastroenterology. 134: A-558. DOI: 10.1016/S0016-5085(08)62604-9  0.534
2007 Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. The European Journal of Neuroscience. 25: 2964-72. PMID 17561811 DOI: 10.1111/J.1460-9568.2007.05576.X  0.578
2006 Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. Descending serotonergic facilitation of spinal ERK activation and pain behavior. Febs Letters. 580: 6629-34. PMID 17113581 DOI: 10.1016/J.Febslet.2006.11.012  0.569
2006 Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. Covariance among age, spinal p38 MAP kinase activation and allodynia. The Journal of Pain : Official Journal of the American Pain Society. 7: 337-45. PMID 16632323 DOI: 10.1016/J.Jpain.2005.12.007  0.684
2006 Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. The European Journal of Neuroscience. 23: 627-36. PMID 16487144 DOI: 10.1111/J.1460-9568.2006.04593.X  0.39
2006 Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. The Journal of Pharmacology and Experimental Therapeutics. 316: 466-75. PMID 16203828 DOI: 10.1124/jpet.105.091686  0.536
2005 Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. The European Journal of Neuroscience. 22: 2431-40. PMID 16307586 DOI: 10.1111/J.1460-9568.2005.04451.X  0.577
2005 Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 39: 485-94. PMID 16176831 DOI: 10.1016/J.Npep.2005.08.002  0.574
2005 Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. Journal of Alternative and Complementary Medicine (New York, N.Y.). 11: 653-61. PMID 16131289 DOI: 10.1089/acm.2005.11.653  0.362
2005 Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL. Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience. 133: 543-53. PMID 15885922 DOI: 10.1016/J.Neuroscience.2005.01.024  0.579
2005 Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. Journal of Neurochemistry. 92: 1508-20. PMID 15748168 DOI: 10.1111/J.1471-4159.2004.02996.X  0.581
2005 Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. British Journal of Pharmacology. 144: 940-52. PMID 15685208 DOI: 10.1038/Sj.Bjp.0706116  0.558
2005 Yaksh TL, Sorkin LS. Mechanisms of neuropathic pain Current Medicinal Chemistry - Central Nervous System Agents. 5: 129-140. DOI: 10.2174/1568015054022380  0.573
2004 Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proceedings of the National Academy of Sciences of the United States of America. 101: 10470-5. PMID 15240875 DOI: 10.1073/Pnas.0403802101  0.373
2004 Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2727-32. PMID 15028765 DOI: 10.1523/Jneurosci.5054-03.2004  0.552
2004 Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1451-8. PMID 14960618 DOI: 10.1523/JNEUROSCI.1517-03.2004  0.349
2004 Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Experimental Neurology. 185: 160-8. PMID 14697327 DOI: 10.1016/j.expneurol.2003.09.015  0.581
2004 Svensson C, Schaefers M, Jones T, Powell H, Yaksh T, Sorkin L. Spinal nociceptive mechanisms The Journal of Pain. 5: S33. DOI: 10.1016/J.Jpain.2004.02.099  0.706
2004 Svensson C, Brainin-Mattos J, Powell H, Luo Z, Yaksh T. Pain pathways The Journal of Pain. 5: S29. DOI: 10.1016/j.jpain.2004.02.081  0.554
2003 Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. Journal of Neurochemistry. 86: 1534-44. PMID 12950462 DOI: 10.1046/J.1471-4159.2003.01969.X  0.582
2003 South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, et al. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5031-40. PMID 12832526 DOI: 10.1523/Jneurosci.23-12-05031.2003  0.516
2003 Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 14: 1153-7. PMID 12821799 DOI: 10.1097/00001756-200306110-00010  0.55
2003 Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3028-38. PMID 12684490  0.584
2003 Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. The Journal of Pharmacology and Experimental Therapeutics. 304: 827-32. PMID 12538839 DOI: 10.1124/Jpet.102.039750  0.502
2002 Eisenach JC, Curry R, Hood DD, Yaksh TL. Phase I safety assessment of intrathecal ketorolac. Pain. 99: 599-604. PMID 12406536 DOI: 10.1016/S0304-3959(02)00208-7  0.305
2002 Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. Journal of Medicinal Chemistry. 45: 3746-54. PMID 12166947 DOI: 10.1021/Jm020108K  0.476
2002 Svensson CI, Yaksh TL. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annual Review of Pharmacology and Toxicology. 42: 553-83. PMID 11807183 DOI: 10.1146/Annurev.Pharmtox.42.092401.143905  0.581
2001 Sorkin LS, Yaksh TL, Doom CM. Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 95: 965-73. PMID 11605940  0.59
2001 Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5847-53. PMID 11487607 DOI: 10.1523/Jneurosci.21-16-05847.2001  0.563
2001 Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. An automated flinch detecting system for use in the formalin nociceptive bioassay. Journal of Applied Physiology (Bethesda, Md. : 1985). 90: 2386-402. PMID 11356806 DOI: 10.1152/Jappl.2001.90.6.2386  0.493
2001 Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1868-75. PMID 11245671  0.556
2001 Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL. Upregulation of Dorsal Root Ganglion α2δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats The Journal of Neuroscience. 21: 1868-1875. DOI: 10.1523/JNEUROSCI.21-06-01868.2001  0.535
2000 Granados-Soto V, Kalcheva I, Hua X, Newton A, Yaksh TL. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 85: 395-404. PMID 10781912 DOI: 10.1016/S0304-3959(99)00281-X  0.544
1999 Sorkin LS, Yaksh TL, Doom CM. Mechanical allodynia in rats is blocked by a Ca2+ permeable AMPA receptor antagonist. Neuroreport. 10: 3523-6. PMID 10619637  0.534
1999 Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proceedings of the National Academy of Sciences of the United States of America. 96: 7680-6. PMID 10393880  0.327
1998 Leung A, Wallace M, Ridgeway B, Yaksh T. Neurosensory Findings after Intravenous Alfentanil and Ketamine Infusions in Neuropathic Pain Patients Anesthesiology. 89: 1152A. DOI: 10.1097/00000542-199809190-00081  0.365
1997 Wallace MS, Lee J, Sorkin L, Dunn JS, Yaksh T, Yu A. Intravenous lidocaine: effects on controlling pain after anti-GD2 antibody therapy in children with neuroblastoma--a report of a series. Anesthesia and Analgesia. 85: 794-6. PMID 9322457 DOI: 10.1097/00000539-199710000-00014  0.571
1997 Slart R, Yu AL, Yaksh TL, Sorkin LS. An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody. Pain. 69: 119-25. PMID 9060021 DOI: 10.1016/S0304-3959(96)03247-2  0.562
1997 Ridgeway B, Wallace M, Gerayli A, Dunn J, Yaksh T. A758 Neurosensory Findings after Intravenous Lidocaine in Patients with Neuropathic Pain Anesthesiology. 87: 758A. DOI: 10.1097/00000542-199709001-00758  0.331
1994 Marsala M, Sorkin LS, Yaksh TL. Transient spinal ischemia in rat: characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 604-14. PMID 8014207 DOI: 10.1038/jcbfm.1994.75  0.559
1994 Isackson J, Wallace M, Ho RJY, Shen D, Yaksh T. Antinociception and Side Effects of L and D Isomer Liposome-encapsulated Alfentanil after Spinal Delivery in Rats Anesthesiology. 81: A915. DOI: 10.1097/00000542-199409001-00914  0.326
1992 Jensen TS, Yaksh TL. Brainstem excitatory amino acid receptors in nociception: Microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior Neuroscience. 46: 535-547. PMID 1347650 DOI: 10.1016/0306-4522(92)90142-O  0.427
1992 Jensen TS, Yaksh TL. The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis Brain Research. 569: 255-267. PMID 1347242 DOI: 10.1016/0006-8993(92)90637-O  0.398
1990 Jensen T, Yaksh T. The nociceptive action of excitatory amino acids in the rat brainstem reticular formation Pain. 41: S168. DOI: 10.1016/0304-3959(90)92473-4  0.369
1989 Yaksh TL, Al-Rodhan NR, Jensen TS. Sites of action of opiates in production of analgesia. Progress in Brain Research. 77: 371-94. PMID 2851148 DOI: 10.1016/S0079-6123(08)62803-4  0.355
1989 Jensen TS, Yaksh TL. Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats Brain Research. 476: 1-9. PMID 2563331 DOI: 10.1016/0006-8993(89)91529-1  0.397
1987 Howe JR, Yaksh TL, Tyce GM. Intrathecal 6-hydroxydopamine or cervical spinal hemisection reduces norepinephrine content, but not the density of alpha 2-adrenoceptors, in the cat lumbar spinal enlargement. Neuroscience. 21: 377-84. PMID 3039400 DOI: 10.1016/0306-4522(87)90128-X  0.441
1987 Howe JR, Yaksh TL, Go VL. The effect of unilateral dorsal root ganglionectomies or ventral rhizotomies on alpha 2-adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord. Neuroscience. 21: 385-94. PMID 2441314 DOI: 10.1016/0306-4522(87)90129-1  0.441
1986 Jensen TS, Yaksh TL. I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat Brain Research. 363: 99-113. PMID 3004644 DOI: 10.1016/0006-8993(86)90662-1  0.466
1986 Jensen TS, Yaksh TL. II. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat Brain Research. 363: 114-127. PMID 3004638 DOI: 10.1016/0006-8993(86)90663-3  0.457
1986 Jensen TS, Yaksh TL. III. Comparison of the antinociceptive action of Mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique Brain Research. 372: 301-312. PMID 2871901 DOI: 10.1016/0006-8993(86)91138-8  0.42
1986 Howe JR, Yaksh TL. Characterization of [3H]rauwolscine binding to alpha 2-adrenoceptor sites in the lumbar spinal cord of the cat: comparison to such binding sites in the cat frontal cerebral cortex. Brain Research. 368: 87-100. PMID 2869820 DOI: 10.1016/0006-8993(86)91045-0  0.441
1986 Micevych PE, Stroink A, Yaksh T, Go VL. Immunochemical studies of substance P and cholecystokinin octapeptide recovery in dorsal horn following unilateral lumbosacral ganglionectomy. Somatosensory Research. 3: 239-60. PMID 2428085 DOI: 10.3109/07367228609144586  0.48
1985 Micevych PE, Yaksh TL, Go VW, Finkelstein JA. Effect of opiates on the release of cholecystokinin from in vitro hypothalamus and frontal cortex of Zucker lean (Fa/-) and obese (fa/fa) rats. Brain Research. 337: 382-5. PMID 3896389 DOI: 10.1016/0006-8993(85)90080-0  0.48
1985 Schmauss C, Shimohigashi Y, Jensen TS, Robbard D, Yaksh TL. Studies on spinal opiate receptor pharmacology. III. Analgetic effects of enkephalin dimers as measured by cutaneous-thermal and visceral-chemical evoked responses Brain Research. 337: 209-215. PMID 2992678 DOI: 10.1016/0006-8993(85)90056-3  0.439
1985 Jensen TS, Yaksh TL. Examination of the Antinociceptive Profile Associated with MU and Delta Opioid Receptor Linked Systems in the Brainstem Periaqueductal Gray Matter (PAG) and the Medullary Reticular Formation (MRF) Cephalalgia. 5: 494-495. DOI: 10.1177/03331024850050S3193  0.39
1985 Jensen TS, Yaksh T. Pharmacology The effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats Pain. 23: 309-310. DOI: 10.1016/0304-3959(85)90124-1  0.375
1984 Micevych PE, Go VLW, Yaksh TL. Simultaneous measurement of cholecystokinin- and vasoactive intestinal polypeptide-like immunoreactivity from cat frontal cortex in vitro: Effect of morphine and d-Ala2-d-Leu5-Enkephalin Brain Research. 291: 55-62. PMID 6697185 DOI: 10.1016/0006-8993(84)90650-4  0.48
1984 Jensen TS, Yaksh TL. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats Brain Research. 296: 285-293. PMID 6322926 DOI: 10.1016/0006-8993(84)90064-7  0.45
1984 Micevych PE, Go VL, Yaksh TL, Finkelstein J. In vitro, release of cholecystokinin from hypothalamus and frontal cortex of Sprague-Dawley, Zucker lean (Fa/-) and obese (fa/fa) rats. Peptides. 5: 73-80. PMID 6200866 DOI: 10.1016/0196-9781(84)90054-8  0.48
1984 Micevych PE, Yaksh TL, Go VL. Studies on the opiate receptor-mediated inhibition of K+-stimulated cholecystokinin and substance P release from cat hypothalamus in vitro. Brain Research. 290: 87-94. PMID 6198038 DOI: 10.1016/0006-8993(84)90738-8  0.48
1984 Jensen TS, Yaksh TL. Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites Brain Research. 321: 287-297. PMID 6149792 DOI: 10.1016/0006-8993(84)90181-1  0.466
1984 Howe JR, Yaksh TL. [3H]p-Aminoclonidine binding to multiple alpha 2-adrenoceptor sites in homogenates of cat frontal cortex and cat spinal cord. European Journal of Pharmacology. 106: 547-59. PMID 6097461 DOI: 10.1016/0014-2999(84)90058-X  0.441
1984 Jensen TS, Yaksh TL. Glutamate-induced analgesia: Effects of intrathecal methysergide, phentolamine and naloxone Pain. 18: S158. DOI: 10.1016/0304-3959(84)90366-X  0.405
1983 Schmauss C, Yaksh TL, Shimohigashi Y, Harty G, Jensen T, Rodbard D. Differential association of spinal μ, δ and κ opioid receptors with cutaneous thermal and visceral chemical nociceptive stimuli in the rat Life Sciences. 33: 653-656. PMID 6319919 DOI: 10.1016/0024-3205(83)90587-8  0.45
1983 Micevych PE, Yaksh TL, Szolcsanyi J. Effect of intrathecal capsaicin analogues on the immunofluorescence of peptides and serotonin in the dorsal horn in rats. Neuroscience. 8: 123-31. PMID 6188075 DOI: 10.1016/0306-4522(83)90031-3  0.48
1983 Howe JR, Wang JY, Yaksh TL. Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. The Journal of Pharmacology and Experimental Therapeutics. 224: 552-8. PMID 6131120  0.441
1982 Yaksh TL, Howe JR. Opiate receptors and their definition by antagonists. Anesthesiology. 56: 246-9. PMID 6278990 DOI: 10.1097/00000542-198204000-00002  0.441
1982 Yaksh TL, Schmauss C, Micevych PE, Abay EO, Go VL. Pharmacological studies on the application, disposition, and release of neurotensin in the spinal cord. Annals of the New York Academy of Sciences. 400: 228-43. PMID 6188399  0.48
1982 Micevych PE, Yaksh TL, Go VL. Opiate-mediated inhibition of the release of cholecystokinin and substance P, but not neurotensin from cat hypothalamic slices. Brain Research. 250: 283-9. PMID 6184121 DOI: 10.1016/0006-8993(82)90422-X  0.48
1982 Howe JR, Yaksh TL. Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration. The Journal of Pharmacology and Experimental Therapeutics. 220: 311-21. PMID 6120226  0.441
1981 Yaksh TL, Elde RP. Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo. Journal of Neurophysiology. 46: 1056-75. PMID 7299446 DOI: 10.1152/JN.1981.46.5.1056  0.463
1980 Yaksh TL, Elde RP. Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo. European Journal of Pharmacology. 63: 359-62. PMID 7389818 DOI: 10.1016/0014-2999(80)90266-6  0.463
1980 Howe JR, Yaksh TL. Supersensitivity to the effects of intrathecally injected norepinephrine and serotonin following the intrathecal treatment of 6-hydroxydopamine or 5,6-dihydroxytryptamine in the rat Pharmacologist. 22: 331.  0.441
1979 Wall PD, Merrill EG, Yaksh TL. Responses of single units in laminae 2 and 3 of cat spinal cord. Brain Research. 160: 245-60. PMID 216459 DOI: 10.1016/0304-3959(79)90014-9  0.701
1978 Merrill EG, Wall PD, Yaksh TL. Properties of two unmyelinated fibre tracts of the central nervous system: lateral Lissauer tract, and parallel fibres of the cerebellum. The Journal of Physiology. 284: 127-45. PMID 731475 DOI: 10.1113/Jphysiol.1978.Sp012531  0.701
1978 Wall PD, Yaksh TL. Effect of Lissauer tract stimulation on activity in dorsal roots and in ventral roots. Experimental Neurology. 60: 570-83. PMID 680058 DOI: 10.1016/0014-4886(78)90011-0  0.428
1975 Pert A, Yaksh T. Localization of the antinociceptive action of morphine in primate brain Pharmacology, Biochemistry and Behavior. 3: 133-138. PMID 1129350 DOI: 10.1016/0091-3057(75)90092-1  0.308
1974 Pert A, Yaksh T. Sites of morphine induced analgesia in the primate brain: relation to pain pathways Brain Research. 80: 135-140. PMID 4424093 DOI: 10.1016/0006-8993(74)90731-8  0.349
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