Tony Yaksh - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
pain, pharmacology

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Year Citation  Score
2020 Gonçalves Dos Santos G, Jimenéz-Andrade JM, Woller SA, Muñoz-Islas E, Ramírez-Rosas MB, Ohashi N, Ferreira Catroli G, Fujita Y, Yaksh TL, Corr M. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Scientific Reports. 10: 15596. PMID 32973194 DOI: 10.1038/s41598-020-72441-5  1
2020 Ramachandran R, Thompson SK, Malkmus S, Gupta S, Mieda T, Lin JH, Yaksh TL. Topical Application of ASN008, a Permanently-charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset and Long Duration of Action in a Mouse Model of Pruritus. The Journal of Pharmacology and Experimental Therapeutics. PMID 32616515 DOI: 10.1124/jpet.120.265074  1
2020 Chernov AV, Hullugundi SK, Eddinger KA, Dolkas J, Remacle AG, Angert M, James BP, Yaksh TL, Strongin AY, Shubayev VI. A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice. The Journal of Biological Chemistry. PMID 32532796 DOI: 10.1074/jbc.RA120.013696  1
2019 Gonçalves Dos Santos G, Delay L, Yaksh TL, Corr M. Neuraxial Cytokines in Pain States. Frontiers in Immunology. 10: 3061. PMID 32047493 DOI: 10.3389/fimmu.2019.03061  1
2019 Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. Lipid rafts in glial cells: Role in neuroinflammation and pain processing. Journal of Lipid Research. PMID 31862695 DOI: 10.1194/jlr.TR119000468  1
2019 Ramachandran R, Wang Z, Saavedra C, Corr M, DiNardo A, Powell SB, Yaksh T. [EXPRESS] Role of Toll-like receptor 4 signaling in mast cell mediated trigeminal pain pathway. Molecular Pain. 1744806919867842. PMID 31342858 DOI: 10.1177/1744806919867842  1
2019 Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, et al. Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling. Anesthesiology. 131: 132-147. PMID 31225809 DOI: 10.1097/ALN.0000000000002730  1
2019 Hildebrand KR, Page LM, Billstrom TM, Steinauer JJ, Eddinger KA, Arjomand S, Yaksh TL. Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog. Neuromodulation : Journal of the International Neuromodulation Society. PMID 31124198 DOI: 10.1111/ner.12963  1
2019 Kokubu S, Eddinger KA, Yamaguchi S, Huerta-Esquivel LL, Schiller PW, Yaksh TL. Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat. Neuromodulation : Journal of the International Neuromodulation Society. PMID 30794333 DOI: 10.1111/ner.12925  1
2018 Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Materials Today (Kidlington, England). 21: 951-959. PMID 31156331 DOI: 10.1016/j.mattod.2018.04.001  1
2018 Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A. Botulinum toxin blocks mast cells and prevents rosacea like inflammation. Journal of Dermatological Science. PMID 30658871 DOI: 10.1016/j.jdermsci.2018.12.004  1
2018 Unger MD, Pleticha J, Steinauer J, Kanwar R, Diehn F, LaVallee KT, Banck MS, Jones B, Yaksh TL, Maus TP, Beutler AS. Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents. Pain Medicine (Malden, Mass.). PMID 30590777 DOI: 10.1093/pm/pny276  0.36
2018 Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Dos Santos GG, Yaksh TL, Corr M. Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice. Brain, Behavior, and Immunity. PMID 30465880 DOI: 10.1016/j.bbi.2018.11.014  1
2018 Kokubu S, Eddinger KA, Nguyen TM, Huerta-Esquivel LL, Yamaguchi S, Schiller PW, Yaksh TL. "Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery". Scandinavian Journal of Pain. PMID 30367811 DOI: 10.1515/sjpain-2018-0120  1
2018 Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats. Pain. PMID 30130298 DOI: 10.1097/j.pain.0000000000001373  0.36
2018 Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. Targeting Toll-like Receptor-4 (TLR4) - Emerging Therapeutic Target for Persistent Pain States. Pain. PMID 29889119 DOI: 10.1097/j.pain.0000000000001306  1
2018 Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Reports. 23: 2667-2677. PMID 29847797 DOI: 10.1016/j.celrep.2018.04.110  1
2018 Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL. A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus. Toxins. 10. PMID 29570628 DOI: 10.3390/toxins10040134  1
2018 Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clinical and Experimental Rheumatology. 36: 172. PMID 29461960  1
2018 Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Seminars in Immunopathology. PMID 29423889 DOI: 10.1007/s00281-017-0669-2  1
2017 Christianson C, BalkisBas D, Holmdahl R, Selva NK, Yaksh T, Corr M, Firestein G, Svensson CI. Pain mechanisms in animal models of rheumatoid arthritis. Scandinavian Journal of Pain. 1: 168-169. PMID 29913950 DOI: 10.1016/j.sjpain.2010.05.006  1
2017 Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL. Target engagement and histopathology of neuraxial resiniferatoxin in dog. Veterinary Anaesthesia and Analgesia. PMID 29361418 DOI: 10.1016/j.vaa.2017.10.005  0.36
2017 Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL. Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation. Toxicology and Applied Pharmacology. PMID 29111148 DOI: 10.1016/j.taap.2017.10.017  1
2017 Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clinical and Experimental Rheumatology. 35: 40-46. PMID 28967373  1
2017 Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 76-85. PMID 28903493 DOI: 10.1093/toxsci/kfx118  1
2017 Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scandinavian Journal of Pain. 16: 1-9. PMID 28850381 DOI: 10.1016/j.sjpain.2016.12.008  1
2017 Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Molecular Pain. 13: 1744806917703112. PMID 28394696 DOI: 10.1177/1744806917703112  0.24
2017 Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, et al. Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor. Scientific Reports. 7: 39662. PMID 28045073 DOI: 10.1038/srep39662  1
2016 Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scandinavian Journal of Pain. 10: 90-102. PMID 28361779 DOI: 10.1016/j.sjpain.2015.10.006  1
2016 Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. PMID 27272672 DOI: 10.1097/ALN.0000000000001166  1
2016 Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. Effects of intraplantar Botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. The European Journal of Neuroscience. PMID 27108664 DOI: 10.1111/ejn.13261  1
2016 Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Rivkah Isseroff R, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain, Behavior, and Immunity. PMID 27044335 DOI: 10.1016/j.bbi.2016.03.026  1
2016 Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain, Behavior, and Immunity. PMID 26970355 DOI: 10.1016/j.bbi.2016.03.003  1
2016 Podvin S, Yaksh T, Hook V. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annual Review of Pharmacology and Toxicology. 56: 511-33. PMID 26738478 DOI: 10.1146/annurev-pharmtox-010715-103042  1
2016 Rijsdijk M, Svensson CI, Wijck AJv, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models Scandinavian Journal of Pain. 10: 90-102. DOI: 10.1016/j.sjpain.2015.10.006  0.4
2015 Pellett S, Yaksh TL, Ramachandran R. Current Status and Future Directions of Botulinum Neurotoxins for Targeting Pain Processing. Toxins. 7: 4519-63. PMID 26556371 DOI: 10.3390/toxins7114519  1
2015 Park HJ, Sandor K, McQueen J, Woller SA, Svensson CI, Corr M, Yaksh TL. The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. European Journal of Pain (London, England). PMID 26517300 DOI: 10.1002/ejp.816  1
2015 Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. The search for novel analgesics: targets and mechanisms. F1000prime Reports. 7: 56. PMID 26097729 DOI: 10.12703/P7-56  1
2015 Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL. The Effects of Intraplantar and Intrathecal Botulinum Toxin Type B on Tactile Allodynia in Mono and Polyneuropathy in the Mouse. Anesthesia and Analgesia. 121: 229-38. PMID 26039418 DOI: 10.1213/ANE.0000000000000777  1
2015 Ramachandran R, Lam C, Yaksh TL. Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents. Neurobiology of Disease. 79: 111-22. PMID 25958249 DOI: 10.1016/j.nbd.2015.04.011  1
2015 Woller SA, Corr M, Yaksh TL. Differences in cisplatin-induced mechanical allodynia in male and female mice. European Journal of Pain (London, England). PMID 25716290 DOI: 10.1002/ejp.679  1
2015 Pleticha J, Malkmus SA, Heilmann LF, Veesart SL, Rezek R, Xu Q, Yaksh TL, Beutler AS. High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs. Gene Therapy. 22: 202-8. PMID 25354684 DOI: 10.1038/gt.2014.96  1
2015 Bas DB, Abdelmoaty S, Sandor K, Codeluppi S, Fitzsimmons B, Steinauer J, Hua XY, Yaksh TL, Svensson CI. Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. European Journal of Pain (London, England). 19: 260-70. PMID 24942612 DOI: 10.1002/ejp.544  1
2014 Ramachandran R, Yaksh TL. Therapeutic use of botulinum toxin in migraine: mechanisms of action. British Journal of Pharmacology. 171: 4177-92. PMID 24819339 DOI: 10.1111/bph.12763  1
2014 Rijsdijk M, van Wijck AJ, Kalkman CJ, Yaksh TL. The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery. Anesthesia and Analgesia. 118: 1097-112. PMID 24781577 DOI: 10.1213/ANE.0000000000000161  1
2014 Yaksh TL. TRPV1 expression regulation… A further step in defining its biology: commentary for K. Zavala et al. "The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons" [Neurosci. Lett. (2014) doi:10.1016/j.neulet.2014.01.021]. Neuroscience Letters. 578: 209-10. PMID 24769421 DOI: 10.1016/j.neulet.2014.04.022  1
2014 Leung A, Shukla S, Li E, Duann JR, Yaksh T. Supraspinal characterization of the thermal grill illusion with fMRI. Molecular Pain. 10: 18. PMID 24612493 DOI: 10.1186/1744-8069-10-18  1
2014 Ishikawa T, Suzuki H, Ishikawa K, Yasuda S, Matsui T, Yamamoto M, Kakeda T, Yamamoto S, Owada Y, Yaksh TL. Spinal cord ischemia/injury. Current Pharmaceutical Design. 20: 5738-43. PMID 24502574  1
2014 Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 120: 951-61. PMID 24492326 DOI: 10.1097/ALN.0000000000000148  1
2014 Marino MJ, Terashima T, Steinauer JJ, Eddinger KA, Yaksh TL, Xu Q. Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior. Pain. 155: 674-84. PMID 24333775 DOI: 10.1016/j.pain.2013.12.009  1
2014 Park HJ, Stokes JA, Corr M, Yaksh TL. Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice. Cancer Chemotherapy and Pharmacology. 73: 25-34. PMID 24162377 DOI: 10.1007/s00280-013-2304-9  1
2014 Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, et al. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 155: 322-33. PMID 24145208 DOI: 10.1016/j.pain.2013.10.015  1
2014 Yaksh T. Comments Neuromodulation. 17: 482. DOI: 10.1111/ner.12142  1
2014 Wiese AJ, Yaksh TL. Nociception and Pain Mechanisms Handbook of Veterinary Pain Management: Third Edition. 10-41. DOI: 10.1016/B978-0-323-08935-7.00002-8  1
2013 Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. Journal of Neuroinflammation. 10: 148. PMID 24321498 DOI: 10.1186/1742-2094-10-148  1
2013 Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL. Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. Anesthesiology. 119: 1163-77. PMID 24051388 DOI: 10.1097/ALN.0b013e3182a95164  1
2013 Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. The Journal of Pharmacology and Experimental Therapeutics. 347: 258-64. PMID 23978562 DOI: 10.1124/jpet.113.206573  1
2013 Nizet V, Yaksh T. Neuroscience: Bacteria get on your nerves. Nature. 501: 43-4. PMID 23965630 DOI: 10.1038/nature12550  1
2013 Terashima T, Xu Q, Yamaguchi S, Yaksh TL. Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression. Neuropharmacology. 75: 1-8. PMID 23810829 DOI: 10.1016/j.neuropharm.2013.06.018  1
2013 Takasusuki T, Yamaguchi S, Hamaguchi S, Yaksh TL. Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology. 119: 433-42. PMID 23708866 DOI: 10.1097/ALN.0b013e31829996b6  1
2013 Svensson E, Persson J, Fitzsimmons B, Yaksh TL. Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia. Neuroscience Letters. 548: 27-32. PMID 23707652 DOI: 10.1016/j.neulet.2013.05.027  1
2013 Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, Walker SM. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 119: 142-55. PMID 23514721 DOI: 10.1097/ALN.0b013e31828fc7e7  1
2013 Stokes JA, Corr M, Yaksh TL. Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ. Pain. 154: 733-42. PMID 23489833 DOI: 10.1016/j.pain.2013.01.012  1
2013 Yaksh TL, Allen JW, Veesart SL, Horais KA, Malkmus SA, Scadeng M, Steinauer JJ, Rossi SS. Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation. Anesthesiology. 118: 664-78. PMID 23426209 DOI: 10.1097/ALN.0b013e31828351aa  1
2013 Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1939-49. PMID 23382512 DOI: 10.1096/fj.12-217414  1
2013 Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 47: 109-15. PMID 23290538 DOI: 10.1016/j.npep.2012.10.006  1
2013 Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesthesia and Analgesia. 116: 224-31. PMID 23223118 DOI: 10.1213/ANE.0b013e31826e1007  1
2013 Yaksh TL, Steinauer JJ, Veesart SL, Malkmus SA. Alfentanil: correlations between absence of effect upon subcutaneous mast cells and absence of granuloma formation after intrathecal infusion in the dog. Neuromodulation : Journal of the International Neuromodulation Society. 16: 459-66; discussion 4. PMID 23170763 DOI: 10.1111/j.1525-1403.2012.00534.x  1
2013 Manciu FS, Lee KH, Durrer WG, Bennet KE. Detection and monitoring of neurotransmitters--a spectroscopic analysis. Neuromodulation : Journal of the International Neuromodulation Society. 16: 192-9; discussion 19. PMID 22989218 DOI: 10.1111/j.1525-1403.2012.00502.x  1
2013 Yaksh TL. A Review of Pain-Processing Pharmacology Practical Management of Pain: Fifth Edition. 99-112. DOI: 10.1016/B978-0-323-08340-9.00009-8  1
2012 Marino M, Huang P, Malkmus S, Robertshaw E, Mac EA, Shatterman Y, Yaksh TL. Development and validation of an automated system for detection and assessment of scratching in the rodent. Journal of Neuroscience Methods. 211: 1-10. PMID 22971351 DOI: 10.1016/j.jneumeth.2012.08.002  1
2012 Deer TR, Levy R, Prager J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: recommendations to reduce morbidity and mortality in intrathecal drug delivery in the treatment of chronic pain. Neuromodulation : Journal of the International Neuromodulation Society. 15: 467-82; discussion 4. PMID 22849581 DOI: 10.1111/j.1525-1403.2012.00486.x  1
2012 Wallace M, Yaksh TL. Characteristics of distribution of morphine and metabolites in cerebrospinal fluid and plasma with chronic intrathecal morphine infusion in humans. Anesthesia and Analgesia. 115: 797-804. PMID 22822192 DOI: 10.1213/ANE.0b013e3182645dfd  1
2012 Lampa J, Westman M, Kadetoff D, Agréus AN, Le Maître E, Gillis-Haegerstrand C, Andersson M, Khademi M, Corr M, Christianson CA, Delaney A, Yaksh TL, Kosek E, Svensson CI. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 12728-33. PMID 22802629 DOI: 10.1073/pnas.1118748109  1
2012 Walker SM, Yaksh TL. Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesthesia and Analgesia. 115: 638-62. PMID 22798528 DOI: 10.1213/ANE.0b013e31826253f2  1
2012 Yaksh TL, de Kater A, Dean R, Best BM, Miljanich GP. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog. Neuromodulation : Journal of the International Neuromodulation Society. 15: 508-19; discussion 5. PMID 22748108 DOI: 10.1111/j.1525-1403.2012.00479.x  1
2012 Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation : Journal of the International Neuromodulation Society. 15: 436-64; discussion 4. PMID 22748024 DOI: 10.1111/j.1525-1403.2012.00476.x  1
2012 Yaksh TL, Ilfeld BM, Wiese AJ. Perineural local anesthetic and adjuvant action: the meaning of an ex vivo data set for efficacy and safety. Regional Anesthesia and Pain Medicine. 37: 366-8. PMID 22660488 DOI: 10.1097/AAP.0b013e31825afa5b  1
2012 Suhail MS, Christianson C, Koehrn F, Malkmus SA, Mitchell W, Corr M, Yaksh TL. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing. 84: 47-52. PMID 22547902 DOI: 10.1016/j.neucom.2011.12.020  1
2012 Cohen SP, White RL, Kurihara C, Larkin TM, Chang A, Griffith SR, Gilligan C, Larkin R, Morlando B, Pasquina PF, Yaksh TL, Nguyen C. Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Annals of Internal Medicine. 156: 551-9. PMID 22508732 DOI: 10.7326/0003-4819-156-8-201204170-00002  1
2012 Deer TR, Prager J, Levy R, Burton A, Buchser E, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs M, Kim P, Kumar K, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: recommendations on trialing for intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation : Journal of the International Neuromodulation Society. 15: 420-35; discussion 4. PMID 22494357 DOI: 10.1111/j.1525-1403.2012.00450.x  1
2012 Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, ... ... Yaksh T, et al. Polyanalgesic Consensus Conference--2012: consensus on diagnosis, detection, and treatment of catheter-tip granulomas (inflammatory masses). Neuromodulation : Journal of the International Neuromodulation Society. 15: 483-95; discussion 4. PMID 22494332 DOI: 10.1111/j.1525-1403.2012.00449.x  1
2012 Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 6721-6. PMID 22493235 DOI: 10.1073/pnas.1110460109  1
2012 Walker SM, Grafe M, Yaksh TL. Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesthesia and Analgesia. 115: 450-60. PMID 22467896 DOI: 10.1213/ANE.0b013e3182501a09  1
2012 Christianson CA, Corr M, Yaksh TL, Svensson CI. K/BxN serum transfer arthritis as a model of inflammatory joint pain. Methods in Molecular Biology (Clifton, N.J.). 851: 249-60. PMID 22351097 DOI: 10.1007/978-1-61779-561-9_19  1
2012 Rijsdijk M, van Wijck AJ, Kalkman CJ, Meulenhoff PC, Grafe MR, Steinauer J, Yaksh TL. Safety assessment and pharmacokinetics of intrathecal methylprednisolone acetate in dogs. Anesthesiology. 116: 170-81. PMID 22139590 DOI: 10.1097/ALN.0b013e31823cf035  1
2012 Christianson CA, Fitzsimmons BL, Shim JH, Agrawal A, Cohen SM, Hua XY, Yaksh TL. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. Neuroscience. 200: 199-210. PMID 22056600 DOI: 10.1016/j.neuroscience.2011.10.019  1
2011 Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 152: 2881-91. PMID 22019135 DOI: 10.1016/j.pain.2011.09.020  1
2011 Kim HJ, Seol TK, Lee HJ, Yaksh TL, Jun JH. The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats. Journal of Anesthesia. 25: 884-91. PMID 21983967 DOI: 10.1007/s00540-011-1240-2  1
2011 Stokes JA, Corr M, Yaksh TL. Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. Neuroscience Letters. 504: 215-8. PMID 21964382 DOI: 10.1016/j.neulet.2011.09.025  1
2011 Fuchigami T, Kakinohana O, Hefferan MP, Lukacova N, Marsala S, Platoshyn O, Sugahara K, Yaksh TL, Marsala M. Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia. Neuroscience. 194: 160-9. PMID 21871540 DOI: 10.1016/j.neuroscience.2011.08.022  1
2011 Yaksh TL. Care to wrestle with a Brazilian armed spider? Pain. 152: 2193-5. PMID 21782344 DOI: 10.1016/j.pain.2011.07.001  1
2011 Yaksh TL. Spinal toxins can have persistent adverse effects. Pain Medicine (Malden, Mass.). 12: 991-2. PMID 21752177 DOI: 10.1111/j.1526-4637.2011.01164.x  1
2011 Xu Q, Yaksh TL. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Current Opinion in Anaesthesiology. 24: 400-7. PMID 21659872 DOI: 10.1097/ACO.0b013e32834871df  1
2011 Takasusuki T, Yaksh TL. Regulation of spinal substance p release by intrathecal calcium channel blockade. Anesthesiology. 115: 153-64. PMID 21577088 DOI: 10.1097/ALN.0b013e31821950c2  1
2011 Huang PP, Khan I, Suhail MS, Malkmus S, Yaksh TL. Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing. Plos One. 6: e19126. PMID 21559464 DOI: 10.1371/journal.pone.0019126  1
2011 Takasusuki T, Yaksh TL. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesthesia and Analgesia. 112: 971-6. PMID 21385982 DOI: 10.1213/ANE.0b013e31820f2a16  1
2011 Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2113-24. PMID 21307248 DOI: 10.1523/JNEUROSCI.2139-10.2011  1
2011 Walker SM, Grafe M, Yaksh TL. Sublethal spinal ketamine produces neuronal apoptosis in rat pups Anesthesiology. 114: 719-721. DOI: 10.1097/ALN.0b013e31820a86b3  1
2011 Yaksh TL. Spinal Delivery and Assessment of Drug Safety Fundamental Neuropathology For Pathologists and Toxicologists: Principles and Techniques. 449-462. DOI: 10.1002/9780470939956.ch27  1
2010 Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. British Journal of Pharmacology. 161: 976-85. PMID 20977450 DOI: 10.1111/j.1476-5381.2010.00954.x  1
2010 Poole R, Blake S, Buschmann M, Goldring S, Laverty S, Lockwood S, Matyas J, McDougall J, Pritzker K, Rudolphi K, van den Berg W, Yaksh T. Recommendations for the use of preclinical models in the study and treatment of osteoarthritis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: S10-6. PMID 20864015 DOI: 10.1016/j.joca.2010.05.027  1
2010 Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 151: 394-403. PMID 20739123 DOI: 10.1016/j.pain.2010.07.030  1
2010 Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. British Journal of Pharmacology. 160: 1754-64. PMID 20649577 DOI: 10.1111/j.1476-5381.2010.00811.x  1
2010 Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Research. 1352: 83-93. PMID 20637741 DOI: 10.1016/j.brainres.2010.07.020  1
2010 Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesthesia and Analgesia. 111: 554-60. PMID 20610553 DOI: 10.1213/ANE.0b013e3181e3a2a2  1
2010 Watabiki T, Nagakura Y, Wegner K, Kakimoto S, Tozier NA, Malkmus SA, Yaksh TL. Assessment of canine sensory function by using sine-wave electrical stimuli paradigm. Physiology & Behavior. 101: 327-30. PMID 20570687 DOI: 10.1016/j.physbeh.2010.05.019  1
2010 Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL. Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology. 113: 183-99. PMID 20526189 DOI: 10.1097/ALN.0b013e3181dcd6ec  1
2010 Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology. 113: 147-59. PMID 20526188 DOI: 10.1097/ALN.0b013e3181dcd71c  1
2010 Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. Journal of Neurochemistry. 114: 981-93. PMID 20492349 DOI: 10.1111/j.1471-4159.2010.06815.x  1
2010 McCann S, Yaksh TL, von Gunten CF. Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study. Journal of Opioid Management. 6: 87-94. PMID 20481173 DOI: 10.5055/jom.2010.0008  1
2010 Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplantation. 19: 1103-22. PMID 20412634 DOI: 10.3727/096368910X503406  1
2010 Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 112: 1216-24. PMID 20395821 DOI: 10.1097/ALN.0b013e3181d94d8b  1
2010 Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 112: 1225-33. PMID 20395820 DOI: 10.1097/ALN.0b013e3181d94dc0  1
2010 Yaksh TL, Eisenach JC, Shafer SL. Consent contraindicated? Science (New York, N.Y.). 328: 45; author reply 45. PMID 20360092 DOI: 10.1126/science.328.5974.45-a  1
2010 Eisenach JC, Shafer SL, Yaksh T. The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 149: 417-9. PMID 20227830 DOI: 10.1016/j.pain.2010.02.028  1
2010 Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 21: 313-7. PMID 20134354 DOI: 10.1097/WNR.0b013e32833774bf  1
2010 Scholz J, Yaksh TL. Preclinical research on persistent postsurgical pain: what we don't know, but should start studying. Anesthesiology. 112: 511-3. PMID 20124975 DOI: 10.1097/ALN.0b013e3181cf4266  1
2010 Yaksh TL. [Vacuoles: a hollow threat?]. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 57: 195-200. PMID 20054677 DOI: 10.1007/s12630-009-9251-2  1
2010 Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neuroscience Letters. 470: 6-9. PMID 20026382 DOI: 10.1016/j.neulet.2009.12.033  1
2010 Mantyh PW, Yaksh TL. An integrative approach to the control of cancer pain The Neurobiology of Pain: (Molecular and Cellular Neurobiology). DOI: 10.1093/acprof:oso/9780198515616.003.0015  1
2010 Yaksh TL, Mantyh PW. Spinal delivery of drugs in pain control The Neurobiology of Pain: (Molecular and Cellular Neurobiology). DOI: 10.1093/acprof:oso/9780198515616.003.0008  1
2010 Yaksh TL. The Pain State Arising From the Laminitic Horse: Insights Into Future Analgesic Therapies Journal of Equine Veterinary Science. 30: 79-82. DOI: 10.1016/j.jevs.2010.01.046  1
2009 Sorkin LS, Yaksh TL. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 609-19. PMID 19789066 DOI: 10.1016/j.nurt.2009.07.007  1
2009 Walker SM, Yaksh TL. New caudal additives in children: benefit vs. risk? Acta Anaesthesiologica Scandinavica. 53: 1097-8; author reply. PMID 19694618 DOI: 10.1111/j.1399-6576.2009.02013.x  1
2009 Cohen SP, Bogduk N, Dragovich A, Buckenmaier CC, Griffith S, Kurihara C, Raymond J, Richter PJ, Williams N, Yaksh TL. Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica. Anesthesiology. 110: 1116-26. PMID 19387178 DOI: 10.1097/ALN.0b013e3181a05aa0  1
2009 Ilfeld BM, Yaksh TL. The end of postoperative pain--a fast-approaching possibility? And, if so, will we be ready? Regional Anesthesia and Pain Medicine. 34: 85-7. PMID 19282704 DOI: 10.1097/AAP.0b013e3181962547  1
2009 Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 136: 1339-48, e1-2. PMID 19249394 DOI: 10.1053/j.gastro.2008.12.044  1
2009 Hua XY, Yaksh TL. Dorsal horn substance P and NK1 receptors: Study of a model system in spinal nociceptive processing Synaptic Plasticity in Pain. 109-138. DOI: 10.1007/978-1-4419-0226-9_6  1
2008 Ray SB, Yaksh TL. Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neuroscience Letters. 448: 260-2. PMID 18973791 DOI: 10.1016/j.neulet.2008.10.067  1
2008 Nazarian A, Christianson CA, Hua XY, Yaksh TL. Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine. British Journal of Pharmacology. 155: 1117-26. PMID 18846040 DOI: 10.1038/bjp.2008.341  1
2008 Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proceedings of the National Academy of Sciences of the United States of America. 105: 12599-604. PMID 18719118 DOI: 10.1073/pnas.0805422105  1
2008 Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 139: 569-77. PMID 18692315 DOI: 10.1016/j.pain.2008.06.014  1
2008 Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL. Acetaminophen prevents hyperalgesia in central pain cascade. Neuroscience Letters. 442: 50-3. PMID 18601979 DOI: 10.1016/j.neulet.2008.06.062  1
2008 Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacology, Biochemistry, and Behavior. 90: 664-75. PMID 18584857 DOI: 10.1016/j.pbb.2008.05.016  1
2008 Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL. Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience. 154: 1077-87. PMID 18511207 DOI: 10.1016/j.neuroscience.2008.04.033  1
2008 Leung AY, Kim SJ, Schulteis G, Yaksh T. The effect of acupuncture duration on analgesia and peripheral sensory thresholds. Bmc Complementary and Alternative Medicine. 8: 18. PMID 18452622 DOI: 10.1186/1472-6882-8-18  1
2008 Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J. Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology. 108: 938-49. PMID 18431131 DOI: 10.1097/ALN.0b013e31816c902a  1
2008 Nazarian A, Gu G, Gracias NG, Wilkinson K, Hua XY, Vasko MR, Yaksh TL. Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P. Neuroscience. 152: 119-27. PMID 18222611 DOI: 10.1016/j.neuroscience.2007.11.037  1
2008 Wegner K, Horais KA, Tozier NA, Rathbun ML, Shtaerman Y, Yaksh TL. Development of a canine nociceptive thermal escape model. Journal of Neuroscience Methods. 168: 88-97. PMID 18054083 DOI: 10.1016/j.jneumeth.2007.09.019  1
2008 Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP. Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology. 54: 269-79. PMID 18037142 DOI: 10.1016/j.neuropharm.2007.09.014  1
2008 Nagakura Y, Malkmus S, Yaksh TL. Determination of current threshold for paw withdrawal with sine-wave electrical stimulation in rats: effect of drugs and alteration in acute inflammation. Pain. 134: 293-301. PMID 17583428 DOI: 10.1016/j.pain.2007.04.030  1
2007 Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M. Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11179-91. PMID 17942713 DOI: 10.1523/JNEUROSCI.0989-07.2007  1
2007 Ilfeld BM, Yaksh TL, Neal JM. Mandating two-year regional anesthesia fellowships: fanning the academic flame or extinguishing it? Regional Anesthesia and Pain Medicine. 32: 275-9. PMID 17720109 DOI: 10.1016/j.rapm.2007.04.001  1
2007 Yaksh TL. Neonates have a spinal alpha receptor too, as do adults. British Journal of Pharmacology. 151: 1139-40. PMID 17641678 DOI: 10.1038/sj.bjp.0707291  1
2007 Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. The European Journal of Neuroscience. 25: 2964-72. PMID 17561811 DOI: 10.1111/j.1460-9568.2007.05576.x  1
2007 Kern SE, Allen J, Wagstaff J, Shafer SL, Yaksh T. The pharmacokinetics of the conopeptide contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles. Anesthesia and Analgesia. 104: 1514-20, table of co. PMID 17513651 DOI: 10.1213/01.ane.0000262038.58546.e6  1
2007 Allen JW, Hofer K, McCumber D, Wagstaff JD, Layer RT, McCabe RT, Yaksh TL. An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesthesia and Analgesia. 104: 1505-13, table of co. PMID 17513650 DOI: 10.1213/01.ANE.0000219586.65112.FA  1
2006 Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. Descending serotonergic facilitation of spinal ERK activation and pain behavior. Febs Letters. 580: 6629-34. PMID 17113581 DOI: 10.1016/j.febslet.2006.11.012  1
2006 Leung AY, Park J, Schulteis G, Duann JR, Yaksh T. The electrophysiology of de qi sensations. Journal of Alternative and Complementary Medicine (New York, N.Y.). 12: 743-50. PMID 17034280 DOI: 10.1089/acm.2006.12.743  1
2006 Allen JW, Horais KA, Tozier NA, Yaksh TL. Opiate pharmacology of intrathecal granulomas. Anesthesiology. 105: 590-8. PMID 16931994 DOI: 10.1097/00000542-200609000-00025  1
2006 Allen JW, Horais KA, Tozier NA, Wegner K, Corbeil JA, Mattrey RF, Rossi SS, Yaksh TL. Time course and role of morphine dose and concentration in intrathecal granuloma formation in dogs: a combined magnetic resonance imaging and histopathology investigation. Anesthesiology. 105: 581-9. PMID 16931993 DOI: 10.1097/00000542-200609000-00024  1
2006 Kakinohana O, Hefferan MP, Nakamura S, Kakinohana M, Galik J, Tomori Z, Marsala J, Yaksh TL, Marsala M. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience. 141: 1569-83. PMID 16797137 DOI: 10.1016/j.neuroscience.2006.04.083  1
2006 Rossi S, Yaksh T, Bentley H, van den Brande G, Grant I, Ellis R. Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clinical Chemistry. 52: 896-7. PMID 16638958 DOI: 10.1373/clinchem.2006.067058  1
2006 Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. Covariance among age, spinal p38 MAP kinase activation and allodynia. The Journal of Pain : Official Journal of the American Pain Society. 7: 337-45. PMID 16632323 DOI: 10.1016/j.jpain.2005.12.007  1
2006 Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, Yaksh TL. Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain. 122: 174-81. PMID 16545911 DOI: 10.1016/j.pain.2006.01.032  1
2006 Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 91: 286-98. PMID 16500924 DOI: 10.1093/toxsci/kfj143  1
2006 Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. The European Journal of Neuroscience. 23: 627-36. PMID 16487144 DOI: 10.1111/j.1460-9568.2006.04593.x  1
2006 Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 7: S13-30. PMID 16426997 DOI: 10.1016/j.jpain.2005.09.007  1
2006 Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. The Journal of Pharmacology and Experimental Therapeutics. 316: 466-75. PMID 16203828 DOI: 10.1124/jpet.105.091686  1
2006 Staats P, Yaksh TL. Ziconotide: Profile report Drugs and Therapy Perspectives. 22: 7-9. DOI: 10.2165/00042310-200622080-00002  1
2006 Staats P, Yaksh TL. Ziconotide: A viewpoint Cns Drugs. 20: 339-341. DOI: 10.2165/00023210-200620040-00008  1
2006 Yaksh TL. Dynamics of the Pain Processing System Pain Management. 1: 21-32. DOI: 10.1016/B978-0-7216-0334-6.50007-8  1
2006 Yaksh TL, Luo ZD. Anatomy of the Pain Processing System Pain Management. 1: 11-20. DOI: 10.1016/B978-0-7216-0334-6.50006-6  1
2005 Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. The European Journal of Neuroscience. 22: 2431-40. PMID 16307586 DOI: 10.1111/j.1460-9568.2005.04451.x  1
2005 Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 39: 485-94. PMID 16176831 DOI: 10.1016/j.npep.2005.08.002  1
2005 Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 118: 112-24. PMID 16154696 DOI: 10.1016/j.pain.2005.08.002  1
2005 Torchia M, Yaksh T. Unexpected pain in a dog: aberration or worthy of a citation? Agree to disagree. Lab Animal. 34: 19. PMID 16136070 DOI: 10.1038/laban0905-19a  1
2005 Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. Journal of Alternative and Complementary Medicine (New York, N.Y.). 11: 653-61. PMID 16131289 DOI: 10.1089/acm.2005.11.653  1
2005 Malkmus S, Lu X, Bartfai T, Yaksh TL, Hua XY. Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice. Neuropeptides. 39: 217-21. PMID 15944015 DOI: 10.1016/j.npep.2004.12.002  1
2005 Hua XY, Salgado KF, Gu G, Fitzsimmons B, Kondo I, Bartfai T, Yaksh TL. Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization? Neuropeptides. 39: 211-6. PMID 15944014 DOI: 10.1016/j.npep.2004.12.024  1
2005 Leung AY, Wallace MS, Schulteis G, Yaksh TL. Qualitative and quantitative characterization of the thermal grill. Pain. 116: 26-32. PMID 15935558 DOI: 10.1016/j.pain.2005.03.026  1
2005 Gu G, Kondo I, Hua XY, Yaksh TL. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. The Journal of Pharmacology and Experimental Therapeutics. 314: 1362-9. PMID 15908510 DOI: 10.1124/jpet.105.087718  1
2005 Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL. Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience. 133: 543-53. PMID 15885922 DOI: 10.1016/j.neuroscience.2005.01.024  1
2005 Smith TJ, Coyne PJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, Buchser E, Català E, Bryce DA, Cousins M, Pool GE, Wallace M, Yaksh T, Magnuson S, et al. An implantable drug delivery system (IDDS) for refractory cancer pain provides sustained pain control, less drug-related toxicity, and possibly better survival compared with comprehensive medical management (CMM) Annals of Oncology. 16: 825-833. PMID 15817596 DOI: 10.1093/annonc/mdi156  1
2005 Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3651-60. PMID 15814796 DOI: 10.1523/JNEUROSCI.0252-05.2005  1
2005 Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. Journal of Neurochemistry. 92: 1508-20. PMID 15748168 DOI: 10.1111/j.1471-4159.2004.02996.x  1
2005 Butler M, Hayes CS, Chappell A, Murray SF, Yaksh TL, Hua XY. Spinal distribution and metabolism of 2'-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats. Neuroscience. 131: 705-15. PMID 15730875 DOI: 10.1016/j.neuroscience.2004.11.038  1
2005 Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. British Journal of Pharmacology. 144: 940-52. PMID 15685208 DOI: 10.1038/sj.bjp.0706116  1
2005 Yaksh TL, Sorkin LS. Mechanisms of neuropathic pain Current Medicinal Chemistry - Central Nervous System Agents. 5: 129-140. DOI: 10.2174/1568015054022380  1
2004 Khan IM, Wennerholm M, Singletary E, Polston K, Zhang L, Deerinck T, Yaksh TL, Taylor P. Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord. Journal of Neurocytology. 33: 543-56. PMID 15906161 DOI: 10.1007/s11068-004-0516-6  1
2004 Marsala M, Kakinohana O, Yaksh TL, Tomori Z, Marsala S, Cizkova D. Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia. The European Journal of Neuroscience. 20: 2401-14. PMID 15525281 DOI: 10.1111/j.1460-9568.2004.03702.x  1
2004 Massie JB, Huang B, Malkmus S, Yaksh TL, Kim CW, Garfin SR, Akeson WH. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. Journal of Neuroscience Methods. 137: 283-9. PMID 15262072 DOI: 10.1016/j.jneumeth.2004.02.036  1
2004 Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proceedings of the National Academy of Sciences of the United States of America. 101: 10470-5. PMID 15240875 DOI: 10.1073/pnas.0403802101  1
2004 Aldrete JA, Follett KA, Yaksh TL, Allen JW, Gradert TL, Baze WB, Satterfield WC, Hildebrand KR, Johansen MJ, Hassenbusch SJ. Intrathecal opioid infusions [2] (multiple letters) Anesthesiology. 101: 256-258. PMID 15220803  1
2004 Koetzner L, Gregory JA, Yaksh TL. Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. The Journal of Pharmacology and Experimental Therapeutics. 311: 356-63. PMID 15175421 DOI: 10.1124/jpet.104.069484  1
2004 Yaksh TL, Allen JW. The use of intrathecal midazolam in humans: a case study of process. Anesthesia and Analgesia. 98: 1536-45, table of co. PMID 15155302  1
2004 Yaksh TL, Allen JW. Preclinical insights into the implementation of intrathecal midazolam: a cautionary tale. Anesthesia and Analgesia. 98: 1509-11. PMID 15155298  1
2004 Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. Intrathecal ketorolac in dogs and rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 322-34. PMID 15141096 DOI: 10.1093/toxsci/kfh168  1
2004 Malkmus SA, Yaksh TL. Intrathecal catheterization and drug delivery in the rat. Methods in Molecular Medicine. 99: 109-21. PMID 15131333 DOI: 10.1385/1-59259-770-X:109  1
2004 Allen JW, Yaksh TL. Tissue injury models of persistent nociception in rats. Methods in Molecular Medicine. 99: 25-34. PMID 15131326 DOI: 10.1385/1-59259-770-X:025  1
2004 Allen JW, Yaksh TL. Assessment of acute thermal nociception in laboratory animals. Methods in Molecular Medicine. 99: 11-23. PMID 15131325 DOI: 10.1385/1-59259-770-X:011  1
2004 Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2727-32. PMID 15028765 DOI: 10.1523/JNEUROSCI.5054-03.2004  1
2004 Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. Intrathecal but not intravenous opioids release adenosine from the spinal cord. The Journal of Pain : Official Journal of the American Pain Society. 5: 64-8. PMID 14975380 DOI: 10.1016/j.jpain.2003.10.001  1
2004 Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1451-8. PMID 14960618 DOI: 10.1523/JNEUROSCI.1517-03.2004  1
2004 Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Experimental Neurology. 185: 160-8. PMID 14697327 DOI: 10.1016/j.expneurol.2003.09.015  1
2004 Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. The Journal of Pharmacology and Experimental Therapeutics. 308: 574-82. PMID 14610237 DOI: 10.1124/jpet.103.058289  1
2003 Khan I, Osaka H, Stanislaus S, Calvo RM, Deerinck T, Yaksh TL, Taylor P. Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways. The Journal of Comparative Neurology. 467: 44-59. PMID 14574679 DOI: 10.1002/cne.10913  1
2003 Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. Journal of Neurochemistry. 86: 1534-44. PMID 12950462 DOI: 10.1046/j.1471-4159.2003.01969.x  1
2003 South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, et al. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5031-40. PMID 12832526  1
2003 Yaksh TL. Preclinical work leading to the development of spinal analgesia. Anesthesiology. 99: 224-5. PMID 12826864 DOI: 10.1097/00000542-200307000-00034  1
2003 Yaksh TL, Horais KA, Tozier NA, Allen JW, Rathbun M, Rossi SS, Sommer C, Meschter C, Richter PJ, Hildebrand KR. Chronically infused intrathecal morphine in dogs. Anesthesiology. 99: 174-87. PMID 12826858 DOI: 10.1097/00000542-200307000-00028  1
2003 Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 14: 1153-7. PMID 12821799 DOI: 10.1097/01.wnr.0000075448.17390.99  1
2003 Hayes CS, Mulkmus SA, Cizkova D, Yaksh TL, Hua XY. A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance. Journal of Neuroscience Methods. 126: 165-73. PMID 12814841 DOI: 10.1016/S0165-0270(03)00078-5  1
2003 Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3028-38. PMID 12684490  1
2003 Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 98: 862-70. PMID 12657847 DOI: 10.1097/00000542-200304000-00012  1
2003 Rossi S, Yaksh T. Rapid quantification of the non-competitive NMDA antagonist MK-801 in canine cerebrospinal fluid and plasma by capillary gas chromatography-nitrogen phosphorus detection. Journal of Pharmaceutical and Biomedical Analysis. 31: 243-50. PMID 12609663 DOI: 10.1016/S0731-7085(02)00603-9  1
2003 Ibuki T, Marsala M, Masuyama T, Yaksh TL. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. British Journal of Pharmacology. 138: 689-97. PMID 12598423 DOI: 10.1038/sj.bjp.0705102  1
2003 Horais K, Hruby V, Rossi S, Cizkova D, Meschter C, Dorr R, Yaksh TL. Effects of chronic intrathecal infusion of a partial differential opioid agonist in dogs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 71: 263-75. PMID 12563112 DOI: 10.1093/toxsci/71.2.263  1
2003 Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. The Journal of Pharmacology and Experimental Therapeutics. 304: 827-32. PMID 12538839 DOI: 10.1124/jpet.102.039750  1
2003 Eisenach JC, Yaksh TL. Epidural ketamine in healthy children--what's the point? Anesthesia and Analgesia. 96: 626; author reply 62. PMID 12538224  1
2002 Yaksh TL, Hassenbusch S, Burchiel K, Hildebrand KR, Page LM, Coffey RJ. Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Medicine (Malden, Mass.). 3: 300-12. PMID 15099235 DOI: 10.1046/j.1526-4637.2002.02048.x  1
2002 Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Experimental Brain Research. 147: 456-63. PMID 12444477 DOI: 10.1007/s00221-002-1217-3  1
2002 Yaksh TL. Future advances in pain pharmacology: what does the present say about the future? Proceedings of the Western Pharmacology Society. 45: 211-8. PMID 12434582  1
2002 Eisenach JC, Yaksh TL. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 97: 1047-9. PMID 12411784 DOI: 10.1097/00000542-200211000-00003  1
2002 Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 99: 397-406. PMID 12406514 DOI: 10.1016/S0304-3959(02)00102-1  1
2002 Khan IM, Singletary E, Alemayehu A, Stanislaus S, Printz MP, Yaksh TL, Taylor P. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Physiological Genomics. 11: 65-72. PMID 12388796 DOI: 10.1152/physiolgenomics.00079.2002  1
2002 Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. Journal of Medicinal Chemistry. 45: 3746-54. PMID 12166947 DOI: 10.1021/jm020108k  1
2002 Hua XY, Moore A, Malkmus S, Murray SF, Dean N, Yaksh TL, Butler M. Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance. Neuroscience. 113: 99-107. PMID 12123688 DOI: 10.1016/S0306-4522(02)00157-4  1
2002 Rossi S, Yaksh T. Rapid quantification of the delta-opioid receptor selective enkephalin DPDPE in canine cerebrospinal fluid by liquid chromatography--mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 772: 73-9. PMID 12016017 DOI: 10.1016/S1570-0232(02)00058-2  1
2002 Yaksh TL, Scott B, LeBel CL. Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation. Neuroscience. 110: 703-10. PMID 11934477 DOI: 10.1016/S0306-4522(01)00608-X  1
2002 Nozaki-Taguchi N, Yaksh TL. Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesthesia and Analgesia. 94: 968-74, table of con. PMID 11916806  1
2002 Nozaki-Taguchi N, Yaksh TL. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 96: 617-26. PMID 11873037 DOI: 10.1097/00000542-200203000-00018  1
2002 Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia. Journal of Clinical Pharmacology. 42: 70-80. PMID 11808827 DOI: 10.1177/0091270002042001008  1
2002 Svensson CI, Yaksh TL. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annual Review of Pharmacology and Toxicology. 42: 553-83. PMID 11807183 DOI: 10.1146/annurev.pharmtox.42.092401.143905  1
2002 Schäfers M, Geis C, Brors D, Yaksh TL, Sommer C. Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 536-45. PMID 11784800  1
2001 Khan IM, Stanislaus S, Zhang L, Vaughn D, Printz MP, Yaksh TL, Taylor P. Spinal nicotinic receptor activity in a genetic model of hypertension. Clinical and Experimental Hypertension (New York, N.Y. : 1993). 23: 555-68. PMID 11710757 DOI: 10.1081/CEH-100106826  1
2001 Sorkin LS, Yaksh TL, Doom CM. Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 95: 965-73. PMID 11605940  1
2001 Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5847-53. PMID 11487607  1
2001 Mantyh PW, Yaksh TL. Sensory neurons are PARtial to pain. Nature Medicine. 7: 772-3. PMID 11433334 DOI: 10.1038/89880  1
2001 Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. Vincristine-induced allodynia in the rat. Pain. 93: 69-76. PMID 11406340 DOI: 10.1016/S0304-3959(01)00294-9  1
2001 Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. An automated flinch detecting system for use in the formalin nociceptive bioassay. Journal of Applied Physiology (Bethesda, Md. : 1985). 90: 2386-402. PMID 11356806  1
2001 Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1868-75. PMID 11245671  1
2001 Yaksh TL. The Farrar/Portenoy article reviewed Oncology. 15: 1451-1453.  1
2000 Bennett G, Deer T, Du Pen S, Rauck R, Yaksh T, Hassenbusch SJ. Future directions in the management of pain by intraspinal drug delivery. Journal of Pain and Symptom Management. 20: S44-50. PMID 10989257 DOI: 10.1016/S0885-3924(00)00201-3  1
2000 Bennett G, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S, Ferrante FM, Hassenbusch SJ, Lou L, Maeyaert J, Penn R, Portenoy RK, Rauck R, Serafini M, Willis KD, ... Yaksh T, et al. Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000. Journal of Pain and Symptom Management. 20: S37-43. PMID 10989256 DOI: 10.1016/S0885-3924(00)00202-5  1
2000 Bennett G, Serafini M, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S, Ferrante FM, Hassenbusch SJ, Lou L, Maeyaert J, Penn R, Portenoy RK, Rauck R, Willis KD, ... Yaksh T, et al. Evidence-based review of the literature on intrathecal delivery of pain medication. Journal of Pain and Symptom Management. 20: S12-36. PMID 10989255 DOI: 10.1016/S0885-3924(00)00204-9  1
2000 Wajima Z, Hua XY, Yaksh TL. Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia. Brain Research. 877: 314-21. PMID 10986346  0.48
2000 Yaksh T, Birnbach DJ. Intrathecal nalbuphine after cesarean delivery: are we ready? Anesthesia and Analgesia. 91: 505-8. PMID 10960366  1
2000 Nishiyama T, Ho RJ, Shen DD, Yaksh TL. The effects of intrathecal morphine encapsulated in L- and D-dipalmitoylphosphatidyl choline liposomes on acute nociception in rats. Anesthesia and Analgesia. 91: 423-8. PMID 10910861  1
2000 Yaksh TL, Provencher JC, Rathbun ML, Myers RR, Powell H, Richter P, Kohn FR. Safety assessment of encapsulated morphine delivered epidurally in a sustained-release multivesicular liposome preparation in dogs. Drug Delivery. 7: 27-36. PMID 10895417 DOI: 10.1080/107175400266768  1
2000 Yang LC, Orendacova J, Wang V, Ishikawa T, Yaksh TL, Marsala M. Transient spinal cord ischemia in rat: the time course of spinal FOS protein expression and the effect of intraischemic hypothermia (27 degrees C). Cellular and Molecular Neurobiology. 20: 351-65. PMID 10789833  0.6
2000 Granados-Soto V, Kalcheva I, Hua X, Newton A, Yaksh TL. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 85: 395-404. PMID 10781912 DOI: 10.1016/S0304-3959(99)00281-X  0.4
2000 Wallace M, Yaksh TL. Long-term spinal analgesic delivery: a review of the preclinical and clinical literature. Regional Anesthesia and Pain Medicine. 25: 117-57. PMID 10746527 DOI: 10.1053/rapm.2000.0250117  1
2000 Ishikawa T, Marsala M, Sakabe T, Yaksh TL. Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist. Neuroscience. 95: 781-6. PMID 10670445  0.6
2000 Yaksh TL. Regulation of spinal nociceptive processing: Where we went when we wandered onto the pain marked by the gate Revista De La Sociedad Espanola Del Dolor. 7: 133-137.  1
2000 Yaksh TL. Analgesics, pain and tolerance: The St John's discussion Pain Research and Management. 5: 19-22.  1
2000 Yaksh TL. Spinal tolerance and dependence: Some observations on the role of spinal N-methyl-D-aspartate receptors and phosphorylation in the loss of opioid analgesic responses Pain Research and Management. 5: 33-39.  1
1999 Dirig DM, Yaksh TL. Spinal synthesis and release of prostanoids after peripheral injury and inflammation. Advances in Experimental Medicine and Biology. 469: 401-8. PMID 10667359  1
1999 Hua XY, Chen P, Yaksh TL. Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats. Neuroscience Letters. 276: 99-102. PMID 10624801  0.48
1999 Sorkin LS, Yaksh TL, Doom CM. Mechanical allodynia in rats is blocked by a Ca2+ permeable AMPA receptor antagonist. Neuroreport. 10: 3523-6. PMID 10619637  1
1999 Yaksh TL. A drug has to do what a drug has to do. Anesthesia and Analgesia. 89: 1075-7. PMID 10553814  1
1999 Luo ZD, Chaplan SR, Scott BP, Cizkova D, Calcutt NA, Yaksh TL. Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9201-8. PMID 10531423 DOI: 10.1523/JNEUROSCI.19-21-09201.1999  0.36
1999 Sailer A, Swanson GT, Pérez-Otaño I, O'Leary L, Malkmus SA, Dyck RH, Dickinson-Anson H, Schiffer HH, Maron C, Yaksh TL, Gage FH, O'Gorman S, Heinemann SF. Generation and analysis of GluR5(Q636R) kainate receptor mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8757-64. PMID 10516295  1
1999 Yaksh TL. Regulation of spinal nociceptive processing: where we went when we wandered onto the path marked by the gate. Pain. S149-52. PMID 10491984  1
1999 Yaksh TL. Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models. Trends in Pharmacological Sciences. 20: 329-37. PMID 10431212 DOI: 10.1016/S0165-6147(99)01370-X  1
1999 Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proceedings of the National Academy of Sciences of the United States of America. 96: 7680-6. PMID 10393880  0.6
1999 Yaksh TL, Provencher JC, Rathbun ML, Kohn FR. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs. Anesthesiology. 90: 1402-12. PMID 10319789 DOI: 10.1097/00000542-199905000-00025  1
1999 Hua XY, Chen P, Marsala M, Yaksh TL. Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids. Neuroscience. 89: 525-34. PMID 10077333  0.6
1999 Yaksh TL. Spinal pharmacology and the regulation of pain processing Biologia - Section Cellular and Molecular Biology. 54: 11-19.  1
1998 Kohn FR, Malkmus SA, Brownson EA, Rossi SS, Yaksh TL. Fate of the predominant phospholipid component of DepoFoam drug delivery matrix after intrathecal administration of sustained-release encapsulated cytarabine in rats. Drug Delivery. 5: 143-51. PMID 19570006 DOI: 10.3109/10717549809031390  0.36
1998 Buerkle H, Yaksh TL. Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat. British Journal of Anaesthesia. 81: 208-15. PMID 9813525  1
1998 Yaksh TL, Dirig DM, Malmberg AB. Mechanism of action of nonsteroidal anti-inflammatory drugs. Cancer Investigation. 16: 509-27. PMID 9774958  0.4
1998 Shreder K, Zhang L, Dang T, Yaksh TL, Umeno H, DeHaven R, Daubert J, Goodman M. Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics. Journal of Medicinal Chemistry. 41: 2631-5. PMID 9651168 DOI: 10.1021/jm970861r  1
1998 Buerkle H, Marsala M, Yaksh TL. Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. British Journal of Anaesthesia. 80: 348-53. PMID 9623437  0.6
1998 Vanický I, Marsala M, Yaksh TL. Neurodegeneration induced by reversed microdialysis of NMDA; a quantitative model for excitotoxicity in vivo. Brain Research. 789: 347-50. PMID 9573401  0.6
1998 Högman M, Reber A, Hua XY, Dueck R, Yaksh TL. Effects of endotracheal intubation on airway neuropeptide content, arterial oxygenation and lung volumes in anaesthetized rats. European Journal of Clinical Investigation. 28: 249-55. PMID 9568472  0.48
1998 Jun JH, Yaksh TL. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesthesia and Analgesia. 86: 348-54. PMID 9459247 DOI: 10.1097/00000539-199802000-00025  1
1998 Hua XY, Chen P, Polgar E, Nagy I, Marsala M, Phillips E, Wollaston L, Urban L, Yaksh TL, Webb M. Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy. Journal of Neurochemistry. 70: 688-98. PMID 9453563  0.6
1998 Partridge BJ, Chaplan SR, Sakamoto E, Yaksh TL. Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology. 88: 196-205. PMID 9447873  0.36
1997 Chritton SL, Chinnow SL, Grabau C, Dousa MK, Lucas D, Roddy D, Yaksh TL, Tyce GM. Adrenomedullary secretion of DOPA, catecholamines, catechol metabolites, and neuropeptides. Journal of Neurochemistry. 69: 2413-20. PMID 9375673  0.52
1997 Dirig DM, Salami A, Rathbun ML, Ozaki GT, Yaksh TL. Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. Journal of Neuroscience Methods. 76: 183-91. PMID 9350970 DOI: 10.1016/S0165-0270(97)00097-6  1
1997 Naguib M, Yaksh TL. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesthesia and Analgesia. 85: 847-53. PMID 9322468 DOI: 10.1097/00000539-199710000-00025  1
1997 Wallace MS, Lee J, Sorkin L, Dunn JS, Yaksh T, Yu A. Intravenous lidocaine: effects on controlling pain after anti-GD2 antibody therapy in children with neuroblastoma--a report of a series. Anesthesia and Analgesia. 85: 794-6. PMID 9322457 DOI: 10.1097/00000539-199710000-00014  1
1997 Yaksh TL, Rathbun ML, Dragani JC, Malkmus S, Bourdeau AR, Richter P, Powell H, Myers RR, Lebel CP. Kinetic and safety studies on intrathecally infused recombinant-methionyl human brain-derived neurotrophic factor in dogs. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 38: 89-100. PMID 9268608 DOI: 10.1006/faat.1997.2314  1
1997 Sharp B, Yaksh T. Pain killers of the immune system. Nature Medicine. 3: 831-2. PMID 9256267 DOI: 10.1038/nm0897-831  1
1997 Hua XY, Chen P, Hwang J, Yaksh TL. Antinociception induced by civamide, an orally active capsaicin analogue. Pain. 71: 313-22. PMID 9231875  0.48
1997 Marsala M, Galik J, Ishikawa T, Yaksh TL. Technique of selective spinal cord cooling in rat: methodology and application. Journal of Neuroscience Methods. 74: 97-106. PMID 9210579  0.6
1997 Dunbar SA, Yaksh TL. Spinal infusion of N-methyl-D-aspartate antagonist MK801 induces hypersensitivity to the spinal alpha-2 agonist ST91 in the rat. The Journal of Pharmacology and Experimental Therapeutics. 281: 1219-25. PMID 9190856  1
1997 Zhang Y, Malmberg AB, Yaksh TL, Sjölund B, Sundler F, Håkanson R. Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo. Regulatory Peptides. 69: 83-7. PMID 9178350  0.4
1997 Dirig DM, Hua XY, Yaksh TL. Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4406-14. PMID 9151757  0.48
1997 Yang LC, Marsala M, Orendacova J, Yaksh TL. Knee joint inflammation attenuates spinal FOS expression after unilateral paw formalin injection in rat. Neuroscience Letters. 225: 89-92. PMID 9147381  0.6
1997 Rossi SS, Moore AC, Hagey LR, Yaksh TL, Chaplan SR. An improved method for the measurement of lidocaine and its metabolites in rat plasma. Therapeutic Drug Monitoring. 19: 179-84. PMID 9108647  0.36
1997 Hwang JH, Yaksh TL. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain. 70: 15-22. PMID 9106805 DOI: 10.1016/S0304-3959(96)03249-6  1
1997 Yaksh TL. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiologica Scandinavica. 41: 94-111. PMID 9061092  1
1997 Slart R, Yu AL, Yaksh TL, Sorkin LS. An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody. Pain. 69: 119-25. PMID 9060021 DOI: 10.1016/S0304-3959(96)03247-2  1
1997 Yaksh TL. Pain after injury: some basic mechanisms. The Journal of the Florida Medical Association. 84: 16-9. PMID 9037993  1
1997 Chaplan SR, Malmberg AB, Yaksh TL. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. The Journal of Pharmacology and Experimental Therapeutics. 280: 829-38. PMID 9023297  0.4
1997 Dowlatshahi P, Yaksh TL. Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesthesia and Analgesia. 84: 133-8. PMID 8989014 DOI: 10.1097/00000539-199701000-00025  1
1997 Yaksh TL, Chaplan SR. Physiology and pharmacology of neuropathic pain Anesthesiology Clinics of North America. 15: 335-352. DOI: 10.1016/S0889-8537(05)70337-0  1
1997 Yaksh TL, Wallace MS. Advances in pain research Anesthesiology Clinics of North America. 15: 229-234. DOI: 10.1016/S0889-8537(05)70330-8  1
1997 Yaksh TL. Physiology and pharmacology of the postinjury pain state Seminars in Anesthesia. 16: 79-91. DOI: 10.1016/S0277-0326(97)80019-0  1
1996 Calcutt NA, Jorge MC, Yaksh TL, Chaplan SR. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain. 68: 293-9. PMID 9121817 DOI: 10.1016/S0304-3959(96)03201-0  0.36
1996 Yaksh TL. Epidural ketamine: a useful, mechanistically novel adjuvant for epidural morphine? Regional Anesthesia. 21: 508-13. PMID 8956385  1
1996 Khan IM, Youngblood KL, Printz MP, Yaksh TL, Taylor P. Spinal nicotinic receptor expression in spontaneously hypertensive rats. Hypertension. 28: 1093-9. PMID 8952602  1
1996 Yang LC, Marsala M, Yaksh TL. Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study. Pain. 67: 345-54. PMID 8951928  0.6
1996 Yang LC, Marsala M, Yaksh TL. Effect of spinal kainic acid receptor activation on spinal amino acid and prostaglandin E2 release in rat. Neuroscience. 75: 453-61. PMID 8931009  0.6
1996 Jhamandas KH, Marsala M, Ibuki T, Yaksh TL. Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2758-66. PMID 8786451  0.6
1996 Hamra JG, Yaksh TL. Halothane inhibits T cell proliferation and interleukin-2 receptor expression in rats. Immunopharmacology and Immunotoxicology. 18: 323-36. PMID 8771374 DOI: 10.3109/08923979609052739  1
1996 Khan IM, Marsala M, Printz MP, Taylor P, Yaksh TL. Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats. The Journal of Pharmacology and Experimental Therapeutics. 278: 97-106. PMID 8764340  1
1996 Zhang Y, Malmberg AB, Sjölund B, Yaksh TL. The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test. Neuroscience Letters. 207: 187-90. PMID 8728481  0.4
1996 Ishikawa T, Yaksh TL. [Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonists]. Masui. the Japanese Journal of Anesthesiology. 45: 439-44. PMID 8725598  1
1996 Hamra JG, Yaksh TL. Equianalgesic doses of subcutaneous but not intrathecal morphine alter phenotypic expression of cell surface markers and mitogen-induced proliferation in rat lymphocytes. Anesthesiology. 85: 355-65. PMID 8712452  1
1996 Galik J, Marsala M, Yaksh TL. Changes in spontaneous unit activity in lumbar spinal cord after reversible aortic occlusion in the rat. Neuroscience Letters. 207: 45-8. PMID 8710206  0.6
1996 Dunbar S, Yaksh TL. Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Neuroscience Letters. 207: 33-6. PMID 8710203 DOI: 10.1016/0304-3940(96)12481-2  1
1996 Lee YW, Yaksh TL. Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. The Journal of Pharmacology and Experimental Therapeutics. 277: 1642-8. PMID 8667233  1
1996 Dunbar S, Yaksh TL. Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Anesthesiology. 84: 1177-88. PMID 8624012 DOI: 10.1097/00000542-199605000-00020  1
1996 Buerkle H, Yaksh TL. Comparison of the spinal actions of the mu-opioid remifentanil with alfentanil and morphine in the rat. Anesthesiology. 84: 94-102. PMID 8572360 DOI: 10.1097/00000542-199601000-00012  1
1996 Yaksh TL. Horizons in Pain Research. San Diego, California, May 19-21, 1995. Anesthesiology. 84: 245-8. PMID 8572351 DOI: 10.1097/00000542-199601000-00043  1
1996 Yaksh TL. Pharmacology of facilitated nociceptive processing Journal of Musculoskeletal Pain. 4: 201-221. DOI: 10.1300/J094v04n01_12  1
1995 Bach FW, Chaplan SR, Jang J, Yaksh TL. Cerebrospinal fluid beta-endorphin in models of hyperalgesia in the rat. Regulatory Peptides. 59: 79-86. PMID 12506417  0.36
1995 Ro S, Zhu Q, Lee CW, Goodman M, Darlak K, Spatola AF, Chung NN, Schiller PW, Malmberg AB, Yaksh TL. Highly potent side chain-main chain cyclized dermorphin-deltorphin analogues: an integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling. Journal of Peptide Science : An Official Publication of the European Peptide Society. 1: 157-74. PMID 9222993 DOI: 10.1002/psc.310010303  1
1995 Hua XY, Wong S, Jinno S, Yaksh TL. Pharmacology of calcitonin gene related peptide release from sensory terminals in the rat trachea. Canadian Journal of Physiology and Pharmacology. 73: 999-1006. PMID 8846444  0.48
1995 Isackson J, Wallace MS, Ho RJ, Shen DD, Yaksh TL. Antinociception and side effects of L- and D-dipalmitoylphosphatidyl choline liposome-encapsulated alfentanil after spinal delivery in rats. Pharmacology & Toxicology. 77: 333-40. PMID 8778746  1
1995 Marsala M, Malmberg AB, Yaksh TL. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. Journal of Neuroscience Methods. 62: 43-53. PMID 8750084  0.6
1995 Yaksh TL, Chaplan SR, Malmberg AB. Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor. Nida Research Monograph. 147: 84-103. PMID 8742782  0.4
1995 Dirig DM, Yaksh TL. Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity. Pain. 62: 321-8. PMID 8657432 DOI: 10.1016/0304-3959(95)00006-E  1
1995 Lee YW, Chaplan SR, Yaksh TL. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neuroscience Letters. 199: 111-4. PMID 8584236  0.36
1995 Calcutt NA, Li L, Yaksh TL, Malmberg AB. Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. European Journal of Pharmacology. 285: 189-97. PMID 8566138 DOI: 10.1016/0014-2999(95)00402-7  0.4
1995 Bach FW, Yaksh TL. Release into ventriculo-cisternal perfusate of beta-endorphin- and Met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat. Brain Research. 690: 167-76. PMID 8535833 DOI: 10.1016/0006-8993(95)00600-U  1
1995 Nagasaka H, Yaksh TL. Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesthesia and Analgesia. 80: 437-43. PMID 7864404 DOI: 10.1097/00000539-199503000-00001  1
1995 Yaksh TL, Grafe MR, Malkmus S, Rathbun ML, Eisenach JC. Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. Anesthesiology. 82: 412-27. PMID 7856900 DOI: 10.1097/00000542-199502000-00012  1
1995 Beutler AS, Banck MS, Bach FW, Gage FH, Porreca F, Bilsky EJ, Yaksh TL. Retrovirus-mediated expression of an artificial beta-endorphin precursor in primary fibroblasts. Journal of Neurochemistry. 64: 475-81. PMID 7830038 DOI: 10.1046/J.1471-4159.1995.64020475.X  0.32
1995 Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 272: 207-14. PMID 7815335  0.36
1995 Malmberg AB, Yaksh TL. The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats. British Journal of Pharmacology. 114: 1069-75. PMID 7780642  1
1995 Yanez AM, Wallace M, Ho R, Shen D, Yaksh TL. Touch-evoked agitation produced by spinally administered phospholipid emulsion and liposomes in rats. Structure-activity relation. Anesthesiology. 82: 1189-98. PMID 7741294 DOI: 10.1097/00000542-199505000-00014  1
1995 Malmberg AB, Yaksh TL. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2768-76. PMID 7722627  1
1995 Malmberg AB, Yaksh TL. Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain. 60: 83-90. PMID 7715945 DOI: 10.1016/0304-3959(94)00094-U  1
1995 Chaplan SR, Bach FW, Shafer SL, Yaksh TL. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology. 83: 775-85. PMID 7574057 DOI: 10.1097/00000542-199510000-00017  1
1995 Yaksh TL, Malmberg AB, Ro S, Schiller P, Goodman M. Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids. The Journal of Pharmacology and Experimental Therapeutics. 275: 63-72. PMID 7562596  0.4
1995 Dirig DM, Yaksh TL. Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. The Journal of Pharmacology and Experimental Therapeutics. 275: 219-27. PMID 7562553  1
1994 Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat Anesthesiology. 80: 383-391. PMID 8311320  1
1994 Marsala M, Yaksh TL. Transient spinal ischemia in the rat: characterization of behavioral and histopathological consequences as a function of the duration of aortic occlusion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 526-35. PMID 8163596 DOI: 10.1038/jcbfm.1994.65  1
1994 Malmberg AB, Yaksh TL. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test European Journal of Pharmacology. 256: 205-209. PMID 8050472 DOI: 10.1016/0014-2999(94)90247-X  1
1994 Malmberg AB, Yaksh TL. Voltage-sensitive calcium channels in spinal nociceptive processing: Blockade of N- and P-type channels inhibits formalin-induced nociception Journal of Neuroscience. 14: 4882-4890. PMID 8046458  1
1994 Marsala M, Sorkin LS, Yaksh TL. Transient spinal ischemia in rat: characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 604-14. PMID 8014207 DOI: 10.1038/jcbfm.1994.75  1
1994 Naguib M, Yaksh TL. Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with μ and α2 receptor systems Anesthesiology. 80: 1338-1348. PMID 8010479  1
1994 Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods. 53: 55-63. PMID 7990513 DOI: 10.1016/0165-0270(94)90144-9  1
1994 Khan IM, Printz MP, Yaksh TL, Taylor P. Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension Hypertension. 24: 611-619. PMID 7960022  1
1994 Patel PM, Drummond JC, Cole DJ, Yaksh TL. Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats. Brain Research. 650: 205-11. PMID 7953685 DOI: 10.1016/0006-8993(94)91783-3  1
1994 Sabbe MB, Grafe MR, Mjanger E, Tiseo PJ, Hill HF, Yaksh TL. Spinal delivery of sufentanil, alfentanil, and morphine in dogs. Physiologic and toxicologic investigations. Anesthesiology. 81: 899-920. PMID 7943841 DOI: 10.1097/00000542-199410000-00017  1
1994 Wallace MS, Yanez AM, Ho RJY, Shen DD, Yaksh TL. Antinociception and side effects of liposome-encapsulated alfentanil after spinal delivery in rats Anesthesia and Analgesia. 79: 778-786. PMID 7943792  1
1994 Yaksh TL. Spinal somatostatin for patients with cancer: Risk-benefit assessment of an analgesic Anesthesiology. 81: 531-533. PMID 7916545 DOI: 10.1097/00000542-199409000-00003  1
1994 Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 58: 413-20. PMID 7838591 DOI: 10.1016/0304-3959(94)90136-8  0.4
1994 Yaksh TL, Rathbun M, Jage J, Mirzai T, Grafe M, Hiles RA. Pharmacology and toxicology of chronically infused epidural clonidine.HCl in dogs. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 23: 319-35. PMID 7835532 DOI: 10.1006/faat.1994.1112  1
1994 Malmberg AB, Yaksh TL. Capsaicin-evoked prostaglandin E2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors. European Journal of Pharmacology. 271: 293-9. PMID 7705429 DOI: 10.1016/0014-2999(94)90786-2  1
1994 Yaksh TL, Rathbun M, Jage J, Mirzai T, Grafe M, Hiles RA. Pharmacology and toxicology of chronically infused epidural clonidine·HCL in dogs Toxicological Sciences. 23: 319-335. DOI: 10.1093/toxsci/23.3.319  1
1993 Yaksh TL. New horizons in our understanding of the spinal physiology and pharmacology of pain processing Seminars in Oncology. 20: 6-18. PMID 8475414  1
1993 Sawynok J, Yaksh TL. Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacological Reviews. 45: 43-85. PMID 8475169  1
1993 Myers RR, Yamamoto T, Yaksh TL, Powell HC. The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia. Anesthesiology. 78: 308-16. PMID 8439027 DOI: 10.1097/00000542-199302000-00015  1
1993 Tiseo PJ, Yaksh TL. Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for δ-opioid receptor subtypes in the rat European Journal of Pharmacology. 236: 89-96. PMID 8391455 DOI: 10.1016/0014-2999(93)90230-F  1
1993 Yamamoto T, Yaksh TL. Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801 Pain. 54: 79-84. PMID 8378105 DOI: 10.1016/0304-3959(93)90102-U  1
1993 Patel PM, Drummond JC, Sano T, Cole DJ, Kalkman CJ, Yaksh TL. Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats. Brain Research. 614: 315-24. PMID 8348324 DOI: 10.1016/0006-8993(93)91050-3  1
1993 Yaksh TL, Malmberg AB. Spinal actions of NSAIDs in blocking spinally mediated hyperalgesia: The role of cyclooxygenase products Agents and Actions. 41: 89-100. PMID 8317344  1
1993 Malmberg AB, Yaksh TL, Calcutt NA. Anti-nociceptive effects of the GM1 ganglioside derivative AGF 44 on the formalin test in normal and streptozotocin-diabetic rats. Neuroscience Letters. 161: 45-8. PMID 8255545 DOI: 10.1016/0304-3940(93)90136-9  0.4
1993 Young RF, Bach FW, Van Norman AS, Yaksh TL. Release of β-endorphin and methionine-enkephalin into cerebrospinal fluid during deep brain stimulation for chronic pain: Effects of stimulation locus and site of sampling Journal of Neurosurgery. 79: 816-825. PMID 8246048 DOI: 10.3171/JNS.1993.79.6.0816  1
1993 Malmberg AB, Yaksh TL. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats Pain. 54: 291-300. PMID 8233543 DOI: 10.1016/0304-3959(93)90028-N  1
1993 Foley KM, Yaksh TL. Another call for patience instead of patients: Developing novel therapies for chronic pain Anesthesiology. 79: 637-640. PMID 8214741  1
1993 Malmberg AB, Yaksh TL. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction Anesthesiology. 79: 270-281. PMID 8102041  1
1993 Yaksh TL. The spinal pharmacology of facilitation of afferent processing evoked by high-threshold afferent input of the postinjury paint state Current Opinion in Neurology and Neurosurgery. 6: 250-256. PMID 8097639  1
1993 Takano Y, Yaksh TL. Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: Spinal alpha2 adrenoceptor subtypes and intrinsic activity Journal of Pharmacology and Experimental Therapeutics. 264: 327-335. PMID 8093729  1
1993 Yamamoto T, Yaksh TL. Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction Pain. 55: 227-233. PMID 7508592 DOI: 10.1016/0304-3959(93)90151-E  1
1993 Yaksh TL. Peripheral opioid actions and analgesia Aps Journal. 2: 66-68. DOI: 10.1016/S1058-9139(05)80148-2  1
1993 Malmberg AB, Yaksh TL. Spinal actions of non-steroidal anti-inflammatory drugs: Evidence for a central role of prostanoids in nociceptive processing Progress in Pharmacology and Clinical Pharmacology. 10: 91-110.  1
1992 Stoddard SL, Tyce GM, Cook JA, Gaumann DM, Yaksh TL. Adrenal medullary secretion with splanchnic stimulation in spinal cats. Journal of the Autonomic Nervous System. 38: 105-16. PMID 1619210 DOI: 10.1016/0165-1838(92)90231-5  1
1992 Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists Pain. 49: 121-128. PMID 1594273 DOI: 10.1016/0304-3959(92)90198-K  1
1992 Stevens CW, Yaksh TL. Studies of morphine and D-ala2-D-leu5-enkephalin (DADLE) cross-tolerance after continuous intrathecal infusion in the rat Anesthesiology. 76: 596-603. PMID 1550284  1
1992 Penning JP, Yaksh TL. Interaction of intrathecal morphine with bupivacaine and lidocaine in the rat Anesthesiology. 77: 1186-1200. PMID 1466469  1
1992 Yamamoto T, Yaksh TL. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat Anesthesiology. 77: 757-763. PMID 1416174 DOI: 10.1097/00000542-199210000-00021  1
1992 Malmberg AB, Yaksh TL. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition Science. 257: 1276-1279. PMID 1381521  1
1992 Jensen TS, Yaksh TL. Brainstem excitatory amino acid receptors in nociception: Microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior Neuroscience. 46: 535-547. PMID 1347650 DOI: 10.1016/0306-4522(92)90142-O  1
1992 Jensen TS, Yaksh TL. The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis Brain Research. 569: 255-267. PMID 1347242 DOI: 10.1016/0006-8993(92)90637-O  1
1992 Saeki S, Yaksh TL. Suppression by spinal alpha-2 agonists of motor and autonomic responses evoked by low- and high-intensity thermal stimuli Journal of Pharmacology and Experimental Therapeutics. 260: 795-802. PMID 1346645  1
1992 Yamamoto T, Yaksh TL. Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat Pain. 51: 329-334. PMID 1337198 DOI: 10.1016/0304-3959(92)90218-Z  1
1992 Malmberg AB, Yaksh TL. Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: Effects of naltrindole and its benzofuran analog (NTB) Journal of Pharmacology and Experimental Therapeutics. 263: 264-275. PMID 1328610  1
1992 Yaksh TL. The spinal pharmacology of acutely and chronically administered opioids Journal of Pain and Symptom Management. 7: 356-361. PMID 1325528 DOI: 10.1016/0885-3924(92)90089-Z  1
1992 Yamamoto T, Yaksh TL. Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy Neuroscience Letters. 135: 67-70. PMID 1311824 DOI: 10.1016/0304-3940(92)90137-V  1
1991 Yaksh TL. Leakage of fluid after epidural injection Pain. 44: 325. PMID 2052401 DOI: 10.1016/0304-3959(91)90104-6  1
1991 Baker AJ, Zornow MH, Scheller MS, Yaksh TL, Skilling SR, Smullin DH, Larson AA, Kuczenski R. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. Journal of Neurochemistry. 57: 1370-9. PMID 1895110  1
1991 Yamamoto T, Yaksh TL. Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction Life Sciences. 49: 1955-1963. PMID 1721102 DOI: 10.1016/0024-3205(91)90637-Q  1
1991 Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors Anesthesiology. 75: 817-826. PMID 1659256  1
1990 Waldman SD, Yaksh TL. Spinal opioids: historical perspectives and future directions. Introduction Journal of Pain and Symptom Management. 5: 137. PMID 2366007 DOI: 10.1016/0885-3924(90)90001-Z  1
1990 Sosnowski M, Yaksh TL. The role of spinal and brainstem adenosine receptors in the modulation of the volume-evoked micturition reflex in the unanesthetized rat Brain Research. 515: 207-213. PMID 2357559 DOI: 10.1016/0006-8993(90)90597-5  1
1990 Carmichael SW, Stoddard SL, O'Connor DT, Yaksh TL, Tyce GM. The secretion of catecholamines, chromogranin A and neuropeptide Y from the adrenal medulla of the cat via the adrenolumbar vein and thoracic duct: different anatomic routes based on size. Neuroscience. 34: 433-40. PMID 2333152 DOI: 10.1016/0306-4522(90)90152-T  1
1990 Sosnowski M, Yaksh TL. Spinal administration of receptor-selective drugs as analgesics: New horizons Journal of Pain and Symptom Management. 5: 204-213. PMID 2164072 DOI: 10.1016/0885-3924(90)90010-H  1
1990 Stevens MK, Yaksh TL. Systematic studies on the effects of the NMDA receptor antagonist MK-801 on cerebral blood flow and responsivity, EEG, and blood-brain barrier following complete reversible cerebral ischemia Journal of Cerebral Blood Flow and Metabolism. 10: 77-88. PMID 2153692 DOI: 10.1038/jcbfm.1990.10  1
1990 Gaumann DM, Yaksh TL. Alpha-chloralose anesthesia inhibits the somato-sympathetic reflex response in cats more effectively than halothane Journal of Veterinary Medicine - Series A. 37: 669-675. PMID 2127972  1
1990 Nagasaka H, Yaksh TL. Pharmacology of intrathecal adrenergic agonists: Cardiovascular and nociceptive reflexes in halothane-anesthetized rats Anesthesiology. 73: 1198-1207. PMID 1978989  1
1990 Sosnowski M, Yaksh TL. Differential cross-tolerance between intrathecal morphine and sufentanil in the rat Anesthesiology. 73: 1141-1147. PMID 1978988  1
1990 Yaksh TL. Extradural somatostatin (I) British Journal of Anaesthesia. 65: 152. PMID 1974453 DOI: 10.1093/bja/65.1.152-a  1
1990 Tiseo PJ, Yaksh TL. The spinal pharmacology of urinary function: studies on urinary continence in the unanaesthetized rat Ciba Foundation Symposium. 151: 91-104; discussion 1. PMID 1699710  1
1990 Onofrio BM, Yaksh TL. Long-term pain relief produced by intrathecal morphine infusion in 53 patients Journal of Neurosurgery. 72: 200-209. PMID 1688618  1
1990 Yaksh TL. The analgesic pharmacology of spinally administered mu opioid agonists Schmerz Pain Douleur. 11: 66-71.  1
1990 Yaksh TL. The Dahlem conference. Berlin, Federal Republic of Germany Anesthesiology. 72: 780.  1
1989 Navarro E, Romero SD, Yaksh TL. CNS stimulation and PGE2 release. III. Pentamethylenetetrazole-induced seizures Journal of Cerebral Blood Flow and Metabolism. 9: 180-186. PMID 2921293 DOI: 10.1038/jcbfm.1989.27  1
1989 Yaksh TL, Collins JG. Studies in animals should precede human use of spinally administered drugs Anesthesiology. 70: 4-6. PMID 2912314  1
1989 Stevens CW, Yaksh TL. Time course characteristics of tolerance development to continuously infused antinociceptive agents in rat spinal cord Journal of Pharmacology and Experimental Therapeutics. 251: 216-223. PMID 2795458  1
1989 Gaumann DM, Yaksh TL, Tyce GM, Stoddard SL. Adrenal vein catecholamines and neuropeptides during splanchnic nerve stimulation in cats. Peptides. 10: 587-92. PMID 2780418 DOI: 10.1016/0196-9781(89)90147-2  1
1989 Stevens CW, Yaksh TL. Opioid dependence after continuous intrathecal infusion of mu and delta opioids in the rat Nida Research Monograph Series. 544-545. PMID 2577051  1
1989 Gaumann DM, Yaksh TL, Wilcox GL, Rodriguez M. Intrathecal somatostatin in cat and mouse studies on pain, motor behavior, and histopathology Anesthesia and Analgesia. 68: 623-632. PMID 2566288  1
1989 Jensen TS, Yaksh TL. Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats Brain Research. 476: 1-9. PMID 2563331 DOI: 10.1016/0006-8993(89)91529-1  1
1989 Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists Pain. 37: 111-123. PMID 2542867 DOI: 10.1016/0304-3959(89)90160-7  1
1989 Stevens CW, Yaksh TL. Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion Journal of Pharmacology and Experimental Therapeutics. 250: 1-8. PMID 2526212  1
1989 Aimone LD, Yaksh TL. Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo Peptides. 10: 1127-1131. PMID 2482963 DOI: 10.1016/0196-9781(89)90003-X  1
1988 Yaksh TL, Harty GJ. Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine Journal of Pharmacology and Experimental Therapeutics. 244: 501-507. PMID 3346833  1
1988 Carmichael SW, Wilson RJ, Brimijoin WS, Melton LJ, Okazaki H, Yaksh TL, Ahlskog JE, Stoddard SL, Tyce GM. Decreased catecholamines in the adrenal medulla of patients with parkinsonism New England Journal of Medicine. 318: 254. PMID 3336415 DOI: 10.1056/NEJM198801283180415  1
1988 Gaumann DM, Yaksh TL. Adrenal and intestinal secretion of catecholamines and neuropeptides during splanchnic artery occlusion shock Circulatory Shock. 26: 391-407. PMID 3214933  1
1988 Stoddard SL, Tyce GM, Carmichael SW, Gaumann DM, Yaksh TL. Effect of acute and chronic spinal transection on evoked secretion of adrenal medullary catecholamines in the cat Journal of the Autonomic Nervous System. 23: 175-179. PMID 3171091 DOI: 10.1016/0165-1838(88)90081-1  1
1988 Stevens MK, Yaksh TL. Time course of release in vivo of PGE2, PGF(2α), 6-keto-PGF(1α), and TxB2 into the brain extracellular space after 15 min of complete global ischemia in the presence and absence of cyclooxygenase inhibition Journal of Cerebral Blood Flow and Metabolism. 8: 790-798. PMID 3142890  1
1988 Navarro E, Romero SD, Yaksh TL. Release of prostaglandin E2 from brain of cat: II. in vivo studies on the effects of adrenergic, cholinergic and dopaminergic agonists and antagonists Neuropharmacology. 27: 1067-1072. PMID 2907118 DOI: 10.1016/0028-3908(88)90069-X  1
1988 Gaumann DM, Yaksh TL. Intrathecal somatostatin in rats. Antinociception only in the presence of toxic effects Anesthesiology. 68: 733-742. PMID 2897175  1
1988 Gaumann DM, Yaksh TL, Tyce GM, Stoddard S. Sympathetic stimulating effects of sufentanil in the cat are mediated centrally Neuroscience Letters. 91: 30-35. PMID 2845307 DOI: 10.1016/0304-3940(88)90244-3  1
1988 Stevens C, Yaksh T. Opioid and adrenergic spinal receptor systems and pain control Nida Research Monograph Series. 343-352. PMID 2841603  1
1988 Yaksh TL. CNS mechanisms of pain and analgesia Cancer Surveys. 7: 5-28. PMID 2838170  1
1988 Yaksh TL. Substance P release from knee joint afferent terminals: modulation by opioids Brain Research. 458: 319-324. PMID 2463049 DOI: 10.1016/0006-8993(88)90474-X  1
1988 Yaksh TL, Michener SR, Bailey JE, Harty GJ, Lucas DL, Nelson DK, Roddy DR, Go VL. Survey of distribution of substance P, vasoactive intestinal polypeptide, cholecystokinin, neurotensin, Met-enkephalin, bombesin and PHI in the spinal cord of cat, dog, sloth and monkey. Peptides. 9: 357-72. PMID 2453858 DOI: 10.1016/0196-9781(88)90272-0  1
1988 Yaksh TL. Frederick W.L. Kerr: Comments on his life with notes on his contributions to the understanding of facial neuralgias Stereotactic and Functional Neurosurgery. 51: 65-75. DOI: 10.1159/000099948  1
1988 Gaumann D, Yaksh TL. Intrathecal somatostatin in rats antinociception only in the presence of toxic effects Regional Anesthesia. 13: 49.  1
1987 Yaksh TL, Onofrio BM. Retrospective consideration of the doses of morphine given intrathecally by chronic infusion in 163 patients by 19 physicians Pain. 31: 211-223. PMID 3431881 DOI: 10.1016/0304-3959(87)90037-6  1
1987 Stevens CW, Yaksh TL. Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord Brain Research. 425: 388-390. PMID 3427441 DOI: 10.1016/0006-8993(87)90527-0  1
1987 Yaksh TL. Reflections on F.W.L. Kerr: a pain scientist Journal of Pain and Symptom Management. 2: 71-74. PMID 3295068  1
1987 Howe JR, Yaksh TL, Tyce GM. Intrathecal 6-hydroxydopamine or cervical spinal hemisection reduces norepinephrine content, but not the density of alpha 2-adrenoceptors, in the cat lumbar spinal enlargement. Neuroscience. 21: 377-84. PMID 3039400 DOI: 10.1016/0306-4522(87)90128-X  1
1987 Yaksh TL. Opioid receptor systems and the endorphins: A review of their spinal organization Journal of Neurosurgery. 67: 157-176. PMID 3037042  1
1987 Stevens CW, Weinger MB, Yaksh TL. Intrathecal dynorphins suppress hindlimb electromyographic activity in rats European Journal of Pharmacology. 138: 299-302. PMID 2887441 DOI: 10.1016/0014-2999(87)90449-3  1
1987 Yaksh TL. Spinal opiates: a review of their effect on spinal function with emphasis on pain processing Acta Anaesthesiologica Scandinavica, Supplement. 85: 25-37. PMID 2821725  1
1987 Howe JR, Yaksh TL, Go VL. The effect of unilateral dorsal root ganglionectomies or ventral rhizotomies on alpha 2-adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord. Neuroscience. 21: 385-94. PMID 2441314 DOI: 10.1016/0306-4522(87)90129-1  1
1987 Yaksh TL. Pharmacology and physiology of spinal analgesia Isi Atlas of Science: Pharmacology. 1: 173-176.  1
1986 Tyce GM, Yaksh TL. Conjugates of biogenic amines in ventriculocisternal perfusates of conscious african green monkeys Brain Research. 372: 269-276. PMID 3708364 DOI: 10.1016/0006-8993(86)91134-0  1
1986 Stevens MK, Yaksh TL, Hansen RB, Anderson RE. Effect of preischemia cyclooxygenase inhibition by zomepirac sodium on reflow, cerebral autoregulation, and EEG recovery in the cat after global ischemia Journal of Cerebral Blood Flow and Metabolism. 6: 691-702. PMID 3098746 DOI: 10.1038/jcbfm.1986.125  1
1986 Walker GE, Yaksh TL. Studies on the effects of intrathalamically injected DADL and morphine on nociceptive thresholds and electroencephalographic activity: A thalamic δ receptor syndrome Brain Research. 383: 1-14. PMID 3021275 DOI: 10.1016/0006-8993(86)90002-8  1
1986 Jensen TS, Yaksh TL. I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat Brain Research. 363: 99-113. PMID 3004644 DOI: 10.1016/0006-8993(86)90662-1  1
1986 Jensen TS, Yaksh TL. II. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat Brain Research. 363: 114-127. PMID 3004638 DOI: 10.1016/0006-8993(86)90663-3  1
1986 Stevens CW, Yaksh TL. Spinal action of dermorphin, an extremely potent opioid peptide from frog skin Brain Research. 385: 300-304. PMID 2877713 DOI: 10.1016/0006-8993(86)91076-0  1
1986 Stevens CW, Yaksh TL. Dynorphin A and related peptides administered intrathecally in the rat: A search for putative kappa opiate receptor activity Journal of Pharmacology and Experimental Therapeutics. 238: 833-838. PMID 2875172  1
1986 Jensen TS, Yaksh TL. III. Comparison of the antinociceptive action of Mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique Brain Research. 372: 301-312. PMID 2871901 DOI: 10.1016/0006-8993(86)91138-8  1
1986 Howe JR, Yaksh TL. Characterization of [3H]rauwolscine binding to alpha 2-adrenoceptor sites in the lumbar spinal cord of the cat: comparison to such binding sites in the cat frontal cerebral cortex. Brain Research. 368: 87-100. PMID 2869820 DOI: 10.1016/0006-8993(86)91045-0  1
1986 Micevych PE, Stroink A, Yaksh T, Go VL. Immunochemical studies of substance P and cholecystokinin octapeptide recovery in dorsal horn following unilateral lumbosacral ganglionectomy. Somatosensory Research. 3: 239-60. PMID 2428085 DOI: 10.3109/07367228609144586  1
1986 Jeftinija S, Raspantini C, Randić M, Yaksh TL, Go VL, Larson AA. Altered responsiveness to substance P and 5-hydroxytryptamine in cat dorsal horn neurons after 5-HT depletion with p-chlorophenylalanine. Brain Research. 368: 107-15. PMID 2420413 DOI: 10.1016/0006-8993(86)91047-4  1
1985 Micevych PE, Yaksh TL, Go VW, Finkelstein JA. Effect of opiates on the release of cholecystokinin from in vitro hypothalamus and frontal cortex of Zucker lean (Fa/-) and obese (fa/fa) rats. Brain Research. 337: 382-5. PMID 3896389 DOI: 10.1016/0006-8993(85)90080-0  1
1985 Schmauss C, Shimohigashi Y, Jensen TS, Robbard D, Yaksh TL. Studies on spinal opiate receptor pharmacology. III. Analgetic effects of enkephalin dimers as measured by cutaneous-thermal and visceral-chemical evoked responses Brain Research. 337: 209-215. PMID 2992678 DOI: 10.1016/0006-8993(85)90056-3  1
1985 Camarata PJ, Yaksh TL. Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray Brain Research. 336: 133-142. PMID 2988700 DOI: 10.1016/0006-8993(85)90424-X  1
1985 Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing Pharmacology, Biochemistry and Behavior. 22: 845-858. PMID 2861606 DOI: 10.1016/0091-3057(85)90537-4  1
1985 Hammond DL, Tyce GM, Yaksh TL. Efflux of 5‐hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla The Journal of Physiology. 359: 151-162. PMID 2582112 DOI: 10.1113/jphysiol.1985.sp015579  1
1984 Hammond DL, Yaksh TL, Tyce GM. Conjugates of Dopamine and Serotonin in Ventriculocisternal Perfusates of the Cat Journal of Neurochemistry. 42: 1752-1757. PMID 6726235 DOI: 10.1111/j.1471-4159.1984.tb12767.x  1
1984 Micevych PE, Go VLW, Yaksh TL. Simultaneous measurement of cholecystokinin- and vasoactive intestinal polypeptide-like immunoreactivity from cat frontal cortex in vitro: Effect of morphine and d-Ala2-d-Leu5-Enkephalin Brain Research. 291: 55-62. PMID 6697185 DOI: 10.1016/0006-8993(84)90650-4  1
1984 Yaksh TL. Obituary for Dr. Frederick W.L. Kerr Pain. 18: 217-220. PMID 6374581 DOI: 10.1016/0304-3959(84)90817-0  1
1984 Hammond DL, Yaksh TL. Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine Brain Research. 298: 329-337. PMID 6326954 DOI: 10.1016/0006-8993(84)91432-X  1
1984 Jensen TS, Yaksh TL. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats Brain Research. 296: 285-293. PMID 6322926 DOI: 10.1016/0006-8993(84)90064-7  1
1984 Schmauss C, Yaksh TL. In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta, and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat Journal of Pharmacology and Experimental Therapeutics. 228: 1-12. PMID 6319664  1
1984 Micevych PE, Go VL, Yaksh TL, Finkelstein J. In vitro, release of cholecystokinin from hypothalamus and frontal cortex of Sprague-Dawley, Zucker lean (Fa/-) and obese (fa/fa) rats. Peptides. 5: 73-80. PMID 6200866 DOI: 10.1016/0196-9781(84)90054-8  1
1984 Micevych PE, Yaksh TL, Go VL. Studies on the opiate receptor-mediated inhibition of K+-stimulated cholecystokinin and substance P release from cat hypothalamus in vitro. Brain Research. 290: 87-94. PMID 6198038 DOI: 10.1016/0006-8993(84)90738-8  1
1984 Yaksh TL. Multiple opioid receptor systems in brain and spinal cord: Part 2 European Journal of Anaesthesiology. 1: 201-243. PMID 6152614  1
1984 Yaksh TL. Multiple opioid receptor systems in brain and spinal cord: Part I European Journal of Anaesthesiology. 1: 171-199. PMID 6152613  1
1984 Jensen TS, Yaksh TL. Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites Brain Research. 321: 287-297. PMID 6149792 DOI: 10.1016/0006-8993(84)90181-1  1
1984 Howe JR, Yaksh TL. [3H]p-Aminoclonidine binding to multiple alpha 2-adrenoceptor sites in homogenates of cat frontal cortex and cat spinal cord. European Journal of Pharmacology. 106: 547-59. PMID 6097461 DOI: 10.1016/0014-2999(84)90058-X  1
1983 Steinman JL, Komisaruk BR, Yaksh TL, Tyce GM. Spinal cord monoamines modulate the antinociceptive effects of vaginal stimulation in rats. Pain. 16: 155-66. PMID 6877846 DOI: 10.1016/0304-3959(83)90205-1  1
1983 Schmauss C, Hammond DL, Ochi JW, Yaksh TL. Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord European Journal of Pharmacology. 90: 349-357. PMID 6688398 DOI: 10.1016/0014-2999(83)90556-3  1
1983 Yaksh TL. Effects of spinally administered agents on spinal cord blood flow: A need for further studies Anesthesiology. 59: 173-174. PMID 6688331  1
1983 Schmauss C, Yaksh TL, Shimohigashi Y, Harty G, Jensen T, Rodbard D. Differential association of spinal μ, δ and κ opioid receptors with cutaneous thermal and visceral chemical nociceptive stimuli in the rat Life Sciences. 33: 653-656. PMID 6319919 DOI: 10.1016/0024-3205(83)90587-8  1
1983 Yaksh TL. In vivo studies on spinal opiate receptor systems mediating antinociception. I. Mu and delta receptor profiles in the primate Journal of Pharmacology and Experimental Therapeutics. 226: 303-316. PMID 6308205  1
1983 Yaksh TL. Spinal pharmacology of pain and its modulation Clinical Neurosurgery. 31: 291-303. PMID 6209049  1
1983 Bergstrom L, Hammond DL, Go VLW, Yaksh TL. Concurrent measurement of substance P and serotonin in spinal superfusates: failure of capsaicin and p-chloroamphetamine to co-release Brain Research. 270: 181-184. PMID 6191841 DOI: 10.1016/0006-8993(83)90812-0  1
1983 Hammond DL, Tyce GM, Yaksh TL. Drug-induced alterations in the efflux of 5-hydroxytryptamine and of 5-hydroxyindoleacetic acid into superfusates of the rat spinal cord European Journal of Pharmacology. 87: 441-448. PMID 6189730 DOI: 10.1016/0014-2999(83)90083-3  1
1983 Micevych PE, Yaksh TL, Szolcsanyi J. Effect of intrathecal capsaicin analogues on the immunofluorescence of peptides and serotonin in the dorsal horn in rats. Neuroscience. 8: 123-31. PMID 6188075 DOI: 10.1016/0306-4522(83)90031-3  1
1983 Howe JR, Wang JY, Yaksh TL. Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. The Journal of Pharmacology and Experimental Therapeutics. 224: 552-8. PMID 6131120  1
1983 Yaksh TL, Hammond DL. Letter to the editor Pain. 17: 313-315. DOI: 10.1016/0304-3959(83)90105-7  1
1983 Yaksh TL. The principles behind the use of spinal narcotics Clinics in Anaesthesiology. 1: 219-232.  1
1982 Tung AS, Yaksh TL. The antinociceptive effects of epidural opiates in the cat: Studies on the pharmacology and the effects of lipophilicity in spinal analgesia Pain. 12: 343-356. PMID 7099701 DOI: 10.1016/0304-3959(82)90179-8  1
1982 Yaksh TL, Harty GJ. Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5]enkephalin European Journal of Pharmacology. 79: 293-300. PMID 7047177 DOI: 10.1016/0014-2999(82)90635-5  1
1982 Schmauss C, Doherty C, Yaksh TL. The analgetic effects of an intrathecally administered partial opiate agonist, nalbuphine hydrochloride European Journal of Pharmacology. 86: 1-7. PMID 6897635 DOI: 10.1016/0014-2999(82)90389-2  1
1982 Yaksh TL, Hammond DL. Peripheral and central substrates involved in the Rostrad transmission of nociceptive information Pain. 13: 1-85. PMID 6287384 DOI: 10.1016/0304-3959(82)90067-7  1
1982 Yaksh TL, Gross KE, Li CH. Studies on the intrathecal effect of beta-endorphin in primate. Brain Research. 241: 261-9. PMID 6286042 DOI: 10.1016/0006-8993(82)91062-9  1
1982 Yaksh TL, Howe JR. Opiate receptors and their definition by antagonists. Anesthesiology. 56: 246-9. PMID 6278990  1
1982 Yaksh TL, Schmauss C, Micevych PE, Abay EO, Go VL. Pharmacological studies on the application, disposition, and release of neurotensin in the spinal cord. Annals of the New York Academy of Sciences. 400: 228-43. PMID 6188399  1
1982 Micevych PE, Yaksh TL, Go VL. Opiate-mediated inhibition of the release of cholecystokinin and substance P, but not neurotensin from cat hypothalamic slices. Brain Research. 250: 283-9. PMID 6184121 DOI: 10.1016/0006-8993(82)90422-X  1
1982 Tung AS, Yaksh TL. In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord Brain Research. 247: 75-83. PMID 6127147 DOI: 10.1016/0006-8993(82)91029-0  1
1982 Howe JR, Yaksh TL. Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration. The Journal of Pharmacology and Experimental Therapeutics. 220: 311-21. PMID 6120226  1
1981 Hammond DL, Yaksh TL. Peripheral and central pathways in pain Pharmacology and Therapeutics. 14: 459-475. PMID 7323138 DOI: 10.1016/0163-7258(81)90038-3  1
1981 Yaksh TL, Elde RP. Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo. Journal of Neurophysiology. 46: 1056-75. PMID 7299446 DOI: 10.1152/JN.1981.46.5.1056  1
1981 Yaksh TL, Tyce GM. Release of norepinephrine and serotonin in cat spinal cord: Direct in vivo evidence for the activation of descending monoamine pathways by somatic stimulation Journal De Physiologie. 77: 483-487. PMID 7288659  1
1981 Yaksh TL, Harty GJ. Simple method for rapid removal of rat spinal cord Brain Research Bulletin. 6: 449-450. PMID 7248810 DOI: 10.1016/S0361-9230(81)80016-0  1
1981 Yaksh TL. The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat Journal of Clinical Pharmacology. 21. PMID 6895380  1
1981 Russell B, Yaksh TL. Antagonism by phenoxybenzamine and pentazocine of the antinociceptive effects of morphine in the spinal cord Neuropharmacology. 20: 575-579. PMID 6894633 DOI: 10.1016/0028-3908(81)90210-0  1
1981 Yaksh TL. Spinal opiate analgesia: Characteristics and principles of action Pain. 11. PMID 6276842 DOI: 10.1016/0304-3959(81)90633-3  1
1981 Hammond DL, Yaksh TL, Tyce GM. Presence of Conjugated 5‐Hydroxytryptamine in In Vivo Superfusates of Rat Spinal Cord Journal of Neurochemistry. 37: 1068-1071. PMID 6172561 DOI: 10.1111/j.1471-4159.1981.tb04501.x  1
1981 Yaksh TL, Reddy SV. Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen Anesthesiology. 54: 451-467. PMID 6112935  1
1981 Tung AS, Yaksh TL. Involvement of multiple opiate receptors in spinally mediated analgesia in the rat Pain. 10.  1
1981 Tung AS, Yaksh TL. Multiple opiate receptors in spinally mediated analgesia Anesthesiology. 55.  1
1981 Tung AS, Yaksh TL. Evaluation of epidural opiates in the cat Anesthesiology. 55.  1
1980 Yaksh TL, Elde RP. Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo. European Journal of Pharmacology. 63: 359-62. PMID 7389818 DOI: 10.1016/0014-2999(80)90266-6  1
1980 Yaksh TL, Tyce GM. Resting and K+-evoked release of serotonin and norepine- phrine in vivo from the rat and cat spinal cord Brain Research. 192: 133-146. PMID 7378777 DOI: 10.1016/0006-8993(80)91014-8  1
1980 Yaksh TL, Jessell TM, Gamse R, Mudge AW, Leeman SE. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature. 286: 155-7. PMID 6157098 DOI: 10.1038/286155a0  1
1980 Yaksh TL. Role of the intrinsic modulatory systems in somesthesis Behavioral and Brain Sciences. 3: 315. DOI: 10.1017/S0140525X00005124  1
1980 Yaksh TL. Pain and analgesia pharmacology of the nociceptive feedback loop Anaesthesia and Intensive Care. 8: 368.  1
1980 Howe JR, Yaksh TL. Supersensitivity to the effects of intrathecally injected norepinephrine and serotonin following the intrathecal treatment of 6-hydroxydopamine or 5,6-dihydroxytryptamine in the rat Pharmacologist. 22: 331.  1
1980 Abay EO, Yaksh TL. Effects of intrathecal capsaicin on thermal, mechanical and chemical nociceptive response in the cat Pharmacologist. 22: 242.  1
1979 Yaksh TL, Wilson PR, Kaiko RF, Inturrisi CE. Analgesia produced by a spinal action of morphine and effects upon parturition in the rat Anesthesiology. 51: 386-392. PMID 582883 DOI: 10.1097/00000542-197911000-00004  1
1979 Yaksh TL. Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray Brain Research. 160: 180-185. PMID 581478 DOI: 10.1016/0006-8993(79)90616-4  1
1979 Yaksh TL, Farb DH, Leeman SE, Jessell TM. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science (New York, N.Y.). 206: 481-3. PMID 228392  1
1979 Wall PD, Merrill EG, Yaksh TL. Responses of single units in laminae 2 and 3 of cat spinal cord. Brain Research. 160: 245-60. PMID 216459 DOI: 10.1016/0304-3959(79)90014-9  1
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