Flaviano Giorgini, Ph.D. - Publications

Affiliations: 
2002 University of Washington, Seattle, Seattle, WA 
Area:
Genetics

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Plos Genetics. 12: e1005995. PMID 27123591 DOI: 10.1371/journal.pgen.1005995  0.52
2016 Breda C, Sathyasaikumar KV, Sograte Idrissi S, Notarangelo FM, Estranero JG, Moore GG, Green EW, Kyriacou CP, Schwarcz R, Giorgini F. Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114543 DOI: 10.1136/jnnp-2016-314597.273  0.52
2015 Maddison DC, Giorgini F. The kynurenine pathway and neurodegenerative disease. Seminars in Cell & Developmental Biology. 40: 134-41. PMID 25773161 DOI: 10.1016/j.semcdb.2015.03.002  0.52
2015 Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM. The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. Cell Death and Differentiation. 22: 1388-96. PMID 25656655 DOI: 10.1038/cdd.2015.1  0.52
2015 Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F. Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour. Human Molecular Genetics. 24: 1077-91. PMID 25305083 DOI: 10.1093/hmg/ddu521  0.52
2015 Smalley JL, Breda C, Mason RP, Kooner G, Luthi-Carter R, Gant TW, Giorgini F. Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models Journal of Molecular Medicine. DOI: 10.1007/s00109-015-1344-5  0.52
2014 Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF. DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease. Cell Death & Disease. 5: e1350. PMID 25058424 DOI: 10.1038/cddis.2014.307  0.52
2014 Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szeg? ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, ... Giorgini F, et al. α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease. 70: 149-61. PMID 24983211 DOI: 10.1016/j.nbd.2014.06.018  0.52
2014 Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Proceedings of the National Academy of Sciences of the United States of America. 111: 7012-7. PMID 24706893 DOI: 10.1073/pnas.1319221111  0.52
2014 Green EW, Fedele G, Giorgini F, Kyriacou CP. A Drosophila RNAi collection is subject to dominant phenotypic effects. Nature Methods. 11: 222-3. PMID 24577271 DOI: 10.1038/nmeth.2856  0.52
2014 Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ. Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Human Molecular Genetics. 23: 3129-37. PMID 24452335 DOI: 10.1093/hmg/ddu022  0.52
2014 Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A. DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease. Human Molecular Genetics. 23: 755-66. PMID 24070869 DOI: 10.1093/hmg/ddt466  0.52
2014 Mason RP, Breda C, Kooner GS, Mallucci GR, Kyriacou CP, Giorgini F. Modeling Huntington Disease in Yeast and Invertebrates Movement Disorders: Genetics and Models: Second Edition. 557-572. DOI: 10.1016/B978-0-12-405195-9.00033-0  0.52
2013 Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ. β-Defensin genomic copy number does not influence the age of onset in Huntington's Disease. Journal of Huntington's Disease. 2: 107-24. PMID 25057107 DOI: 10.3233/JHD-130002  0.52
2013 Giorgini F, Steinert JR. Rab11 as a modulator of synaptic transmission. Communicative & Integrative Biology. 6: e26807. PMID 24563714 DOI: 10.4161/cib.26807  0.52
2013 Giorgini F, Huang SY, Sathyasaikumar KV, Notarangelo FM, Thomas MA, Tararina M, Wu HQ, Schwarcz R, Muchowski PJ. Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. The Journal of Biological Chemistry. 288: 36554-66. PMID 24189070 DOI: 10.1074/jbc.M113.503813  0.52
2013 Woodacre A, Lone MA, Jablonowski D, Schneiter R, Giorgini F, Schaffrath R. A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast. Oxidative Medicine and Cellular Longevity. 2013: 129645. PMID 24082981 DOI: 10.1155/2013/129645  0.52
2013 Giorgini F. A flexible polyglutamine hinge opens new doors for understanding huntingtin function. Proceedings of the National Academy of Sciences of the United States of America. 110: 14516-7. PMID 23975930 DOI: 10.1073/pnas.1313668110  0.52
2013 Mason RP, Casu M, Butler N, Breda C, Campesan S, Clapp J, Green EW, Dhulkhed D, Kyriacou CP, Giorgini F. Glutathione peroxidase activity is neuroprotective in models of Huntington's disease. Nature Genetics. 45: 1249-54. PMID 23974869 DOI: 10.1038/ng.2732  0.52
2013 Giorgini F. Understanding neuronal dysfunction and loss in neurodegenerative disease. Journal of Molecular Medicine (Berlin, Germany). 91: 651-2. PMID 23674065 DOI: 10.1007/s00109-013-1053-x  0.52
2013 Amaral M, Outeiro TF, Scrutton NS, Giorgini F. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. Journal of Molecular Medicine (Berlin, Germany). 91: 705-13. PMID 23636512 DOI: 10.1007/s00109-013-1046-9  0.52
2013 Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 496: 382-5. PMID 23575632 DOI: 10.1038/nature12039  0.52
2013 Uthman S, Bär C, Scheidt V, Liu S, ten Have S, Giorgini F, Stark MJ, Schaffrath R. The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network. Plos Genetics. 9: e1003334. PMID 23468660 DOI: 10.1371/journal.pgen.1003334  0.52
2013 Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F. Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells. Journal of Molecular Medicine (Berlin, Germany). 91: 599-611. PMID 23183826 DOI: 10.1007/s00109-012-0976-y  0.52
2012 Kwan W, Träger U, Davalos D, Chou A, Bouchard J, Andre R, Miller A, Weiss A, Giorgini F, Cheah C, Möller T, Stella N, Akassoglou K, Tabrizi SJ, Muchowski PJ. Mutant huntingtin impairs immune cell migration in Huntington disease. The Journal of Clinical Investigation. 122: 4737-47. PMID 23160193 DOI: 10.1172/JCI64484  0.52
2012 Green EW, Giorgini F. Choosing and using Drosophila models to characterize modifiers of Huntington's disease. Biochemical Society Transactions. 40: 739-45. PMID 22817726 DOI: 10.1042/BST20120072  0.52
2012 Green EW, Campesan S, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. Drosophila eye color mutants as therapeutic tools for Huntington disease. Fly. 6: 117-20. PMID 22634544 DOI: 10.4161/fly.19999  0.52
2012 Steinert JR, Campesan S, Richards P, Kyriacou CP, Forsythe ID, Giorgini F. Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease. Human Molecular Genetics. 21: 2912-22. PMID 22466800 DOI: 10.1093/hmg/dds117  0.52
2011 Mason RP, Giorgini F. Modeling Huntington disease in yeast: perspectives and future directions. Prion. 5: 269-76. PMID 22052350 DOI: 10.4161/pri.18005  0.52
2011 Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, ... Giorgini F, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 145: 863-74. PMID 21640374 DOI: 10.1016/j.cell.2011.05.020  0.52
2011 Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Current Biology : Cb. 21: 961-6. PMID 21636279 DOI: 10.1016/j.cub.2011.04.028  0.52
2011 Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, Glynn P, Cain K, Kyriacou CP, Giorgini F, Nicotera P. Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease. Cell Death and Differentiation. 18: 191-200. PMID 21217767 DOI: 10.1038/cdd.2010.127  0.52
2011 Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF, Muchowski PJ, Giorgini F. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. The Journal of Biological Chemistry. 286: 410-9. PMID 21044956 DOI: 10.1074/jbc.M110.101527  0.52
2010 Thevandavakkam MA, Schwarcz R, Muchowski PJ, Giorgini F. Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease. Cns & Neurological Disorders Drug Targets. 9: 791-800. PMID 20942784  0.52
2010 Hands SL, Mason R, Sajjad MU, Giorgini F, Wyttenbach A. Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease. Biochemical Society Transactions. 38: 552-8. PMID 20298220 DOI: 10.1042/BST0380552  0.52
2009 Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ. Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9104-14. PMID 19605647 DOI: 10.1523/JNEUROSCI.2250-09.2009  0.52
2009 Giorgini F, Muchowski PJ. Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease. Methods in Molecular Biology (Clifton, N.J.). 548: 161-74. PMID 19521824 DOI: 10.1007/978-1-59745-540-4_9  0.52
2008 Miller-Fleming L, Giorgini F, Outeiro TF. Yeast as a model for studying human neurodegenerative disorders. Biotechnology Journal. 3: 325-38. PMID 18228539 DOI: 10.1002/biot.200700217  0.52
2008 Giorgini F, Möller T, Kwan W, Zwilling D, Wacker JL, Hong S, Tsai LC, Cheah CS, Schwarcz R, Guidetti P, Muchowski PJ. Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. The Journal of Biological Chemistry. 283: 7390-400. PMID 18079112 DOI: 10.1074/jbc.M708192200  0.52
2006 Giorgini F, Muchowski PJ. Screening for genetic modifiers of amyloid toxicity in yeast. Methods in Enzymology. 412: 201-22. PMID 17046660 DOI: 10.1016/S0076-6879(06)12013-3  0.52
2006 Outeiro TF, Giorgini F. Yeast as a drug discovery platform in Huntington's and Parkinson's diseases. Biotechnology Journal. 1: 258-69. PMID 16897706 DOI: 10.1002/biot.200500043  0.52
2006 Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S. A network of protein interactions determines polyglutamine toxicity. Proceedings of the National Academy of Sciences of the United States of America. 103: 11051-6. PMID 16832049 DOI: 10.1073/pnas.0604548103  0.52
2005 Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nature Genetics. 37: 526-31. PMID 15806102 DOI: 10.1038/ng1542  0.52
2005 Giorgini F, Muchowski PJ. Connecting the dots in Huntington's disease with protein interaction networks. Genome Biology. 6: 210. PMID 15774033 DOI: 10.1186/gb-2005-6-3-210  0.52
2002 Giorgini F, Davies HG, Braun RE. Translational repression by MSY4 inhibits spermatid differentiation in mice. Development (Cambridge, England). 129: 3669-79. PMID 12117816  0.52
2001 Giorgini F, Davies HG, Braun RE. MSY2 and MSY4 bind a conserved sequence in the 3' untranslated region of protamine 1 mRNA in vitro and in vivo. Molecular and Cellular Biology. 21: 7010-9. PMID 11564883 DOI: 10.1128/MCB.21.20.7010-7019.2001  0.52
2000 Clifford R, Lee MH, Nayak S, Ohmachi M, Giorgini F, Schedl T. FOG-2, a novel F-box containing protien, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline Development. 127: 5265-5276. PMID 11076749  0.52
2000 Davies HG, Giorgini F, Fajardo MA, Braun RE. A sequence-specific RNA binding complex expressed in murine germ cells contains MSY2 and MSY4. Developmental Biology. 221: 87-100. PMID 10772793 DOI: 10.1006/dbio.2000.9658  0.52
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