| Year |
Citation |
Score |
| 2022 |
Krafft GA, Jerecic J, Siemers E, Cline EN. ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer's Disease. Frontiers in Neuroscience. 16: 848215. PMID 35557606 DOI: 10.3389/fnins.2022.848215 |
0.372 |
|
| 2018 |
Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging. Scientific Reports. 8: 4634. PMID 29545579 DOI: 10.1038/S41598-018-22979-2 |
0.394 |
|
| 2014 |
Goure WF, Krafft GA, Jerecic J, Hefti F. Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics. Alzheimer's Research & Therapy. 6: 42. PMID 25045405 DOI: 10.1186/Alzrt272 |
0.526 |
|
| 2013 |
Hefti F, Goure WF, Jerecic J, Iverson KS, Walicke PA, Krafft GA. The case for soluble Aβ oligomers as a drug target in Alzheimer's disease. Trends in Pharmacological Sciences. 34: 261-6. PMID 23582316 DOI: 10.1016/J.Tips.2013.03.002 |
0.457 |
|
| 2013 |
Krafft G, Hefti F, Goure W, Jerecic J, Iverson K, Walicke P. O2-06-03: ACU-193: A candidate therapeutic antibody that selectively targets soluble beta-amyloid oligomers Alzheimer's & Dementia. 9: P326-P326. DOI: 10.1016/J.Jalz.2013.04.166 |
0.417 |
|
| 2010 |
Krafft GA, Klein WL. ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology. 59: 230-42. PMID 20650286 DOI: 10.1016/J.Neuropharm.2010.07.012 |
0.49 |
|
| 2010 |
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Annals of Neurology. 68: 220-30. PMID 20641005 DOI: 10.1002/Ana.22052 |
0.327 |
|
| 2009 |
Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. The Journal of Biological Chemistry. 284: 18742-53. PMID 19406747 DOI: 10.1074/Jbc.M109.011015 |
0.33 |
|
| 2008 |
Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Amyloid beta oligomers induce impairment of neuronal insulin receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 246-60. PMID 17720802 DOI: 10.1096/Fj.06-7703Com |
0.385 |
|
| 2007 |
Look GC, Jerecic J, Cherbavaz DB, Pray TR, Breach JC, Crosier WJ, Igoudin L, Hironaka CM, Lowe RM, McEntee M, Ruslim-Litrus L, Wu HM, Zhang S, Catalano SM, Goure WF, ... ... Krafft GA, et al. Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease. Current Alzheimer Research. 4: 562-7. PMID 18220523 DOI: 10.2174/156720507783018271 |
0.45 |
|
| 2007 |
Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. Journal of Neurochemistry. 100: 23-35. PMID 17116235 DOI: 10.1111/J.1471-4159.2006.04157.X |
0.5 |
|
| 2006 |
Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG. The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease. Current Topics in Medicinal Chemistry. 6: 597-608. PMID 16712494 DOI: 10.2174/156802606776743066 |
0.538 |
|
| 2005 |
Krafft G. [AM-03]: Oligomers/Protofibrials/ADDLs Alzheimer's & Dementia. 1: S1-S1. DOI: 10.1016/j.jalz.2005.06.030 |
0.353 |
|
| 2004 |
Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10191-200. PMID 15537891 DOI: 10.1523/Jneurosci.3432-04.2004 |
0.502 |
|
| 2003 |
Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 42: 12749-60. PMID 14596589 DOI: 10.1021/Bi030029Q |
0.471 |
|
| 2003 |
Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proceedings of the National Academy of Sciences of the United States of America. 100: 10417-22. PMID 12925731 DOI: 10.1073/Pnas.1834302100 |
0.52 |
|
| 2003 |
Stine WB, Dahlgren KN, Krafft GA, LaDu MJ. In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. The Journal of Biological Chemistry. 278: 11612-22. PMID 12499373 DOI: 10.1074/Jbc.M210207200 |
0.493 |
|
| 2003 |
Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 118-20. PMID 12424218 DOI: 10.1096/Fj.01-0987Fje |
0.625 |
|
| 2002 |
Dahlgren KN, Manelli AM, Stine WB, Baker LK, Krafft GA, LaDu MJ. Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. The Journal of Biological Chemistry. 277: 32046-53. PMID 12058030 DOI: 10.1074/Jbc.M201750200 |
0.474 |
|
| 2002 |
Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Research. 924: 133-40. PMID 11750898 DOI: 10.1016/S0006-8993(01)03058-X |
0.47 |
|
| 2002 |
Morgan TE, Krafft GA. Chapter 4. Emerging themes in Alzheimer's disease research: Paradigm shift in drug discovery Annual Reports in Medicinal Chemistry. 37: 31-40. DOI: 10.1016/S0065-7743(02)37005-2 |
0.307 |
|
| 2001 |
Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL. Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies. Journal of Neurochemistry. 79: 595-605. PMID 11701763 DOI: 10.1046/J.1471-4159.2001.00592.X |
0.49 |
|
| 2001 |
Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends in Neurosciences. 24: 219-24. PMID 11250006 DOI: 10.1016/S0166-2236(00)01749-5 |
0.53 |
|
| 1998 |
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6448-53. PMID 9600986 DOI: 10.1073/Pnas.95.11.6448 |
0.492 |
|
| 1998 |
Hu J, Akama KT, Krafft GA, Chromy BA, Van Eldik LJ. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Research. 785: 195-206. PMID 9518610 DOI: 10.1016/S0006-8993(97)01318-8 |
0.516 |
|
| 1997 |
Berg MM, Krafft GA, Klein WL. Rapid impact of beta-amyloid on paxillin in a neural cell line. Journal of Neuroscience Research. 50: 979-89. PMID 9452012 DOI: 10.1002/(Sici)1097-4547(19971215)50:6<979::Aid-Jnr8>3.0.Co;2-A |
0.471 |
|
| 1997 |
Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal. Chemical Research in Toxicology. 10: 518-26. PMID 9168248 DOI: 10.1021/Tx970009N |
0.485 |
|
| 1996 |
Zhang C, Qiu HE, Krafft GA, Klein WL. A beta peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line. Neuroscience Letters. 211: 187-90. PMID 8817572 DOI: 10.1016/0304-3940(96)12761-0 |
0.456 |
|
| 1996 |
Roher AE, Chaney MO, Kuo YM, Webster SD, Stine WB, Haverkamp LJ, Woods AS, Cotter RJ, Tuohy JM, Krafft GA, Bonnell BS, Emmerling MR. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. The Journal of Biological Chemistry. 271: 20631-5. PMID 8702810 DOI: 10.1074/Jbc.271.34.20631 |
0.482 |
|
| 1996 |
Zhang C, Qiu HE, Krafft GA, Klein WL. Protein kinase C and F-actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G-proteins and amyloid beta protein. Febs Letters. 386: 185-8. PMID 8647278 DOI: 10.1016/0014-5793(96)00435-8 |
0.358 |
|
| 1996 |
Stine WB, Snyder SW, Ladror US, Wade WS, Miller MF, Perun TJ, Holzman TF, Krafft GA. The Nanometer-scale structure of amyloid-β visualized by atomic force microscopy Protein Journal. 15: 193-203. DOI: 10.1007/Bf01887400 |
0.381 |
|
| 1995 |
Sabo S, Lambert MP, Kessey K, Wade W, Krafft G, Klein WL. Interaction of beta-amyloid peptides with integrins in a human nerve cell line. Neuroscience Letters. 184: 25-8. PMID 7739799 DOI: 10.1016/0304-3940(94)11159-G |
0.507 |
|
| 1995 |
Kohnken RE, Ladror US, Wang GT, Holznan TF, Miller BE, Krafft GA. Cathepsin D from Alzheimer's-Diseased and Normal Brains Experimental Neurology. 133: 105-112. PMID 7649217 DOI: 10.1006/Exnr.1995.1013 |
0.387 |
|
| 1994 |
Giordano T, Pan JB, Monteggia LM, Holzman TF, Snyder SW, Krafft G, Ghanbari H, Kowall NW. Similarities between beta amyloid peptides 1-40 and 40-1: effects on aggregation, toxicity in vitro, and injection in young and aged rats. Experimental Neurology. 125: 175-82. PMID 8313936 DOI: 10.1006/Exnr.1994.1022 |
0.443 |
|
| 1994 |
Snyder SW, Wang GT, Barrett L, Ladror US, Casuto D, Lee CM, Krafft GA, Holzman RB, Holzman TF. Complement C1q does not bind monomeric beta-amyloid. Experimental Neurology. 128: 136-42. PMID 8070518 DOI: 10.1006/Exnr.1994.1121 |
0.486 |
|
| 1994 |
Ladror US, Wang GT, Klein WL, Holzman TF, Krafft GA. Potential βPP-processing proteinase activities from alzheimer's and control brain tissues Journal of Protein Chemistry. 13: 357-366. PMID 7986341 DOI: 10.1007/Bf01901691 |
0.356 |
|
| 1994 |
Ladror US, Kohnken RE, Wang GT, Manelli AM, Frail DE, Klein WL, Holzman TF, Krafft GA. Evidence against a role for the Kunitz domain in amyloidogenic and secretory processing of the amyloid precursor protein. Journal of Neurochemistry. 63: 2225-30. PMID 7964742 DOI: 10.1046/J.1471-4159.1994.63062225.X |
0.459 |
|
| 1994 |
Zhang C, Lambert MP, Bunch C, Barber K, Wade WS, Krafft GA, Klein WL. Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. The Journal of Biological Chemistry. 269: 25247-50. PMID 7929215 |
0.404 |
|
| 1994 |
Pope WB, Lambert MP, Leypold B, Seupaul R, Sletten L, Krafft G, Klein WL. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Experimental Neurology. 126: 185-94. PMID 7925819 DOI: 10.1006/Exnr.1994.1057 |
0.352 |
|
| 1994 |
Snyder SW, Ladror US, Wade WS, Wang GT, Barrett LW, Matayoshi ED, Huffaker HJ, Krafft GA, Holzman TF. Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophysical Journal. 67: 1216-28. PMID 7811936 DOI: 10.1016/S0006-3495(94)80591-0 |
0.465 |
|
| 1994 |
Wang GT, Ladror US, Holzman TF, Klein WL, Krafft GA. Cleavage of fluorogenic substrates for APP-processing proteases by human brain extracts. Ca(2+)-substrate interaction is responsible for Ca2+ stimulation of the neural protease activity. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 23: 191-9. PMID 7702708 DOI: 10.1007/Bf02815411 |
0.366 |
|
| 1994 |
Lambert MP, Stevens G, Sabo S, Barber K, Wang G, Wade W, Krafft G, Snyder S, Holzman TF, Klein WL. Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells. Journal of Neuroscience Research. 39: 377-85. PMID 7533843 DOI: 10.1002/Jnr.490390404 |
0.42 |
|
| 1993 |
Krafft GA. Chapter 6. Perspectives on Amyloid and Alzheimer's Disease: A Critical Review Annual Reports in Medicinal Chemistry. 28: 49-58. DOI: 10.1016/S0065-7743(08)60876-3 |
0.319 |
|
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