Grant A. Krafft - Publications

Affiliations: 
Northwestern University, Evanston, IL 
Area:
Neuroscience Biology

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Goure WF, Krafft GA, Jerecic J, Hefti F. Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics. Alzheimer's Research & Therapy. 6: 42. PMID 25045405 DOI: 10.1186/alzrt272  0.56
2013 Hefti F, Goure WF, Jerecic J, Iverson KS, Walicke PA, Krafft GA. The case for soluble Aβ oligomers as a drug target in Alzheimer's disease. Trends in Pharmacological Sciences. 34: 261-6. PMID 23582316 DOI: 10.1016/j.tips.2013.03.002  0.56
2010 Krafft GA, Klein WL. ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology. 59: 230-42. PMID 20650286 DOI: 10.1016/j.neuropharm.2010.07.012  0.56
2010 Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Annals of Neurology. 68: 220-30. PMID 20641005 DOI: 10.1002/ana.22052  0.56
2009 Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. The Journal of Biological Chemistry. 284: 18742-53. PMID 19406747 DOI: 10.1074/jbc.M109.011015  0.56
2008 Kelley NW, Vishal V, Krafft GA, Pande VS. Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach. The Journal of Chemical Physics. 129: 214707. PMID 19063575 DOI: 10.1063/1.3010881  0.56
2008 Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Amyloid beta oligomers induce impairment of neuronal insulin receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 246-60. PMID 17720802 DOI: 10.1096/fj.06-7703com  0.56
2007 Look GC, Jerecic J, Cherbavaz DB, Pray TR, Breach JC, Crosier WJ, Igoudin L, Hironaka CM, Lowe RM, McEntee M, Ruslim-Litrus L, Wu HM, Zhang S, Catalano SM, Goure WF, ... ... Krafft GA, et al. Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease. Current Alzheimer Research. 4: 562-7. PMID 18220523 DOI: 10.2174/156720507783018271  0.56
2007 Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. Journal of Neurochemistry. 100: 23-35. PMID 17116235 DOI: 10.1111/j.1471-4159.2006.04157.x  0.56
2006 Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG. The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease. Current Topics in Medicinal Chemistry. 6: 597-608. PMID 16712494 DOI: 10.2174/156802606776743066  0.56
2004 Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10191-200. PMID 15537891 DOI: 10.1523/JNEUROSCI.3432-04.2004  0.56
2003 Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 42: 12749-60. PMID 14596589 DOI: 10.1021/bi030029q  0.56
2003 Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proceedings of the National Academy of Sciences of the United States of America. 100: 10417-22. PMID 12925731 DOI: 10.1073/pnas.1834302100  0.56
2003 Stine WB, Dahlgren KN, Krafft GA, LaDu MJ. In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. The Journal of Biological Chemistry. 278: 11612-22. PMID 12499373 DOI: 10.1074/jbc.M210207200  0.56
2003 Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 118-20. PMID 12424218 DOI: 10.1096/fj.01-0987fje  0.56
2002 Dahlgren KN, Manelli AM, Stine WB, Baker LK, Krafft GA, LaDu MJ. Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. The Journal of Biological Chemistry. 277: 32046-53. PMID 12058030 DOI: 10.1074/jbc.M201750200  0.56
2002 Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Research. 924: 133-40. PMID 11750898 DOI: 10.1016/S0006-8993(01)03058-X  0.56
2002 Morgan TE, Krafft GA. Chapter 4. Emerging themes in Alzheimer's disease research: Paradigm shift in drug discovery Annual Reports in Medicinal Chemistry. 37: 31-40.  0.56
2001 Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL. Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies. Journal of Neurochemistry. 79: 595-605. PMID 11701763 DOI: 10.1046/j.1471-4159.2001.00592.x  0.56
2001 Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends in Neurosciences. 24: 219-24. PMID 11250006 DOI: 10.1016/S0166-2236(00)01749-5  0.56
1999 Komano H, Rockwell N, Wang GT, Krafft GA, Fuller RS. Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). The Journal of Biological Chemistry. 274: 24431-7. PMID 10446224 DOI: 10.1074/jbc.274.34.24431  0.56
1998 Komano H, Seeger M, Gandy S, Wang GT, Krafft GA, Fuller RS. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. The Journal of Biological Chemistry. 273: 31648-51. PMID 9822624 DOI: 10.1074/jbc.273.48.31648  0.56
1998 Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6448-53. PMID 9600986 DOI: 10.1073/pnas.95.11.6448  0.56
1998 Hu J, Akama KT, Krafft GA, Chromy BA, Van Eldik LJ. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Research. 785: 195-206. PMID 9518610 DOI: 10.1016/S0006-8993(97)01318-8  0.56
1997 Berg MM, Krafft GA, Klein WL. Rapid impact of beta-amyloid on paxillin in a neural cell line. Journal of Neuroscience Research. 50: 979-89. PMID 9452012 DOI: 10.1002/(SICI)1097-4547(19971215)50:6<979::AID-JNR8>3.0.CO;2-A  0.56
1997 Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal. Chemical Research in Toxicology. 10: 518-26. PMID 9168248 DOI: 10.1021/tx970009n  0.56
1997 Rockwell NC, Wang GT, Krafft GA, Fuller RS. Internally consistent libraries of fluorogenic substrates demonstrate that Kex2 protease specificity is generated by multiple mechanisms. Biochemistry. 36: 1912-7. PMID 9048578 DOI: 10.1021/bi961779l  0.56
1997 Brown ER, Barlow AK, Bodovitz S, Finch CE, Krafft GA, Klein WK. Binding of toxic aoligomers to neuronal cell surface proteins Faseb Journal. 11: A974.  0.56
1996 Zhang C, Qiu HE, Krafft GA, Klein WL. A beta peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line. Neuroscience Letters. 211: 187-90. PMID 8817572 DOI: 10.1016/0304-3940(96)12761-0  0.56
1996 Roher AE, Chaney MO, Kuo YM, Webster SD, Stine WB, Haverkamp LJ, Woods AS, Cotter RJ, Tuohy JM, Krafft GA, Bonnell BS, Emmerling MR. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. The Journal of Biological Chemistry. 271: 20631-5. PMID 8702810 DOI: 10.1074/jbc.271.34.20631  0.56
1996 Zhang C, Qiu HE, Krafft GA, Klein WL. Protein kinase C and F-actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G-proteins and amyloid beta protein. Febs Letters. 386: 185-8. PMID 8647278 DOI: 10.1016/0014-5793(96)00435-8  0.56
1996 Stine WB, Snyder SW, Ladror US, Wade WS, Miller MF, Perun TJ, Holzman TF, Krafft GA. The Nanometer-scale structure of amyloid-β visualized by atomic force microscopy Protein Journal. 15: 193-203. DOI: 10.1007/BF01887400  0.56
1996 Stine WB, Snyder SW, Ladror US, Wade WS, Miller MF, Perun TJ, Holzman TF, Krafft GA. The Nanometer-scale structure of amyloid-β visualized by atomic force microscopy Protein Journal. 15: 193-203.  0.56
1995 Kohnken RE, Ladror US, Wang GT, Holznan TF, Miller BE, Krafft GA. Cathepsin D from Alzheimer's-Diseased and Normal Brains Experimental Neurology. 133: 105-112. PMID 7649217 DOI: 10.1006/exnr.1995.1013  0.56
1995 Wang GT, Li S, Wideburg N, Krafft GA, Kempf DJ. Synthetic chemical diversity: Solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores Journal of Medicinal Chemistry. 38: 2995-3002. PMID 7636862  0.56
1995 Oda T, Wals P, Osterburg HH, Johnson SA, Pasinetti GM, Morgan TE, Rozovsky I, Stine WB, Snyder SW, Holzman TF. Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress. Experimental Neurology. 136: 22-31. PMID 7589331 DOI: 10.1006/exnr.1995.1080  0.56
1994 Snyder SW, Wang GT, Barrett L, Ladror US, Casuto D, Lee CM, Krafft GA, Holzman RB, Holzman TF. Complement C1q does not bind monomeric beta-amyloid. Experimental Neurology. 128: 136-42. PMID 8070518 DOI: 10.1006/exnr.1994.1121  0.56
1994 Ladror US, Snyder SW, Wang GT, Holzman TF, Krafft GA. Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-β by cathepsin D Journal of Biological Chemistry. 269: 18422-18428. PMID 8034590  0.56
1994 Ladror US, Wang GT, Klein WL, Holzman TF, Krafft GA. Potential βPP-processing proteinase activities from alzheimer's and control brain tissues Journal of Protein Chemistry. 13: 357-366. PMID 7986341 DOI: 10.1007/BF01901691  0.56
1994 Ladror US, Kohnken RE, Wang GT, Manelli AM, Frail DE, Klein WL, Holzman TF, Krafft GA. Evidence against a role for the Kunitz domain in amyloidogenic and secretory processing of the amyloid precursor protein. Journal of Neurochemistry. 63: 2225-30. PMID 7964742  0.56
1994 Zhang C, Lambert MP, Bunch C, Barber K, Wade WS, Krafft GA, Klein WL. Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. The Journal of Biological Chemistry. 269: 25247-50. PMID 7929215  0.56
1994 Snyder SW, Ladror US, Wade WS, Wang GT, Barrett LW, Matayoshi ED, Huffaker HJ, Krafft GA, Holzman TF. Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophysical Journal. 67: 1216-28. PMID 7811936 DOI: 10.1016/S0006-3495(94)80591-0  0.56
1994 Wang GT, Ladror US, Holzman TF, Klein WL, Krafft GA. Cleavage of fluorogenic substrates for APP-processing proteases by human brain extracts. Ca(2+)-substrate interaction is responsible for Ca2+ stimulation of the neural protease activity. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 23: 191-9. PMID 7702708 DOI: 10.1007/BF02815411  0.56
1994 Krafft GA. Research and development challenges for Alzheimer's disease drug discovery Neurobiology of Aging. 15. PMID 7700463  0.56
1994 Wang GT, Lane B, Fesik SW, Petros A, Luly J, Krafft GA. Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506 Bioorganic and Medicinal Chemistry Letters. 4: 1161-1166. DOI: 10.1016/S0960-894X(01)80248-1  0.56
1993 Wang GT, Chung CC, Holzman TF, Krafft GA. A continuous fluorescence assay of renin activity Analytical Biochemistry. 210: 351-359. PMID 8512070 DOI: 10.1006/abio.1993.1207  0.56
1993 Krafft GA. Chapter 6. Perspectives on Amyloid and Alzheimer's Disease: A Critical Review Annual Reports in Medicinal Chemistry. 28: 49-58. DOI: 10.1016/S0065-7743(08)60876-3  0.56
1992 Zlemnicka-Merchant B, Aran JM, Plagemann PGW, Krafft GA. Effects of chemical modification of nitrobenzylthioinosine on its binding to high-affinity membrane binding sites and inhibition of nucleoside transport Biochemical Pharmacology. 44: 1577-1583. PMID 1417982 DOI: 10.1016/0006-2952(92)90475-X  0.56
1992 Wang GT, Krafft GA. Automated synthesis of fluorogenic protease substrates: design of probes for alzheimer's disease-associated proteases Bioorganic and Medicinal Chemistry Letters. 2: 1665-1668. DOI: 10.1016/S0960-894X(00)80452-7  0.56
1991 Holzman TF, Chung CC, Edalji R, Egan DA, Martin M, Gubbins EJ, Krafft GA, Wang GT, Thomas AM, Rosenberg SH, Hutchins C. Characterization of recombinant human renin: Kinetics, pH-stability, and peptidomimetic inhibitor binding Journal of Protein Chemistry. 10: 553-563. PMID 1799412 DOI: 10.1007/BF01025483  0.56
1990 Matayoshi ED, Wang GT, Krafft GA, Erickson J. Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer Science. 247: 954-958. PMID 2106161  0.56
1990 Holzman TF, Chung CC, Edalji R, Egan DA, Gubbins EJ, Rueter A, Howard G, Yang LK, Pederson TM, Krafft GA, Wang GT. Recombinant human prorenin from CHO cells: Expression and purification Journal of Protein Chemistry. 9: 663-672. PMID 1963533 DOI: 10.1007/BF01024761  0.56
1990 Krafft GA, Wang GT. Chapter 32. Catalytic Antibodies: A New Class of Designer Enzymes Annual Reports in Medicinal Chemistry. 25: 299-308. DOI: 10.1016/S0065-7743(08)60036-6  0.56
1990 Wang GT, Matayoshi E, Jan Huffaker H, Krafft GA. Design and synthesis of new fluorogenic HIV protease substrates based on resonance energy transfer Tetrahedron Letters. 31: 6493-6496. DOI: 10.1016/S0040-4039(00)97099-0  0.56
1990 Wang GT, Matayoshi E, Erickson JW, Krafft GA. Fluorogenic determination of structural requirements for HIV protease substrates Annals of the New York Academy of Sciences. 616: 617-619.  0.56
1988 Walling EA, Krafft GA, Ware BR. Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery Archives of Biochemistry and Biophysics. 264: 321-332. PMID 3395126 DOI: 10.1016/0003-9861(88)90600-5  0.56
1988 Cummings RT, DiZio JP, Krafft GA. Photoactivable fluorophores. 2. Synthesis and photoactivation of functionalized 3-aroyl-2-(2-furyl)-chromones Tetrahedron Letters. 29: 69-72. DOI: 10.1016/0040-4039(88)80018-2  0.56
1988 Cummings RT, Krafft GA. Photoactivable fluorophores. 1. Synthesis and photoactivation of o-nitrobenzyl-quenched fluorescent carbamates Tetrahedron Letters. 29: 65-68. DOI: 10.1016/0040-4039(88)80017-0  0.56
1988 Meinke PT, Krafft GA. Synthesis and cycloaddition reactivity of selenoaldehydes Journal of the American Chemical Society. 110: 8671-8679.  0.56
1988 Meinke PT, Krafft GA. Preparation and cycloaddition reactions of selenoketones Journal of the American Chemical Society. 110: 8679-8685.  0.56
1988 Meinke PT, Krafft GA, Guram A. Synthesis of selenocyanates via cyanoselenation of organocopper reagents Journal of Organic Chemistry. 53: 3632-3634.  0.56
1988 Krafft GA, Sutton WR, Cummings RT. Photoactivable fluorophores. 3. Synthesis and photoactivation of fluorogenic difunctionalized fluoresceins Journal of the American Chemical Society. 110: 301-303.  0.56
1987 Meinke PT, Krafft GA, Spencer JT. Selenofluorenone: Synthesis and cycloaddition chemistry Tetrahedron Letters. 28: 3887-3890. DOI: 10.1016/S0040-4039(00)96411-6  0.56
1987 Meinke PT, Krafft GA. Regiochemical preferences in selenoaldehyde cycloadditions Tetrahedron Letters. 28: 5121-5124. DOI: 10.1016/S0040-4039(00)95607-7  0.56
1986 Krafft GA, Garcia EA, Guram A, O'Shaughnessy B, Xu X. Simplified cytochalasins. 1. Synthesis of versatile perhydroisoindolone intermediates Tetrahedron Letters. 27: 2691-2694. DOI: 10.1016/S0040-4039(00)84618-3  0.56
1986 Krafft GA, Meinke PT. Selenoaldehydes: Preparation and dienophilic reactivity Journal of the American Chemical Society. 108: 1314-1315.  0.56
1985 Krafft GA, Meinke PT. Generation of thioaldehydes via fluoride induced elimination of α-silyldisulfides Tetrahedron Letters. 26: 1947-1950. DOI: 10.1016/S0040-4039(00)98348-5  0.56
1985 Krafft GA, Siddall TL. Stereospecific displacement of sulfur from chiral centers. activation via thiaphosphonium salts Tetrahedron Letters. 26: 4867-4870. DOI: 10.1016/S0040-4039(00)94972-4  0.56
1985 Krafft GA, Meinke PT. Functionalization of furans via phenacyl sulfides Tetrahedron Letters. 26: 135-138. DOI: 10.1016/S0040-4039(00)61862-2  0.56
1982 Chakravarty PK, Krafft GA, Katzenellenbogen JA. Haloenol lactones: enzyme-activated irreversible inactivators for serine proteases. Inactivation of alpha-chymotrypsin Journal of Biological Chemistry. 257: 610-612. PMID 7054169  0.56
1982 Vedejs E, Krafft GA. Cyclic sulfides in organic synthesis Tetrahedron. 38: 2857-2881. DOI: 10.1016/0040-4020(82)85013-8  0.56
1982 Krafft GA, Reich MF, Katzenellenbogen JA. Synthesis of 14C-labeled 10,11-epoxyfarnesyl diazoacetate, a potential photoaffinity labeling reagent for insect juvenile hormone binding proteins Journal of Labelled Compounds and Radiopharmaceuticals. 19: 591-596. DOI: 10.1002/jlcr.2580190413  0.56
1982 Vedejs E, Arnost MJ, Eustache JM, Krafft GA. Model study for synthesis of the cytochalasin D cycloundecanone ring system Journal of Organic Chemistry. 47: 4384-4386.  0.56
1981 Krafft GA, Katzenellenbogen JA. Synthesis of halo enol lactones. Mechanism-based inactivators of serine proteases Journal of the American Chemical Society. 103: 5459-5466.  0.56
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