Adrian R. Krainer - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Area:
mRNA splicing
Website:
http://www.cshl.edu/Faculty/krainer-adrian-r.html

163 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Nomakuchi TT, Rigo F, Aznarez I, Krainer AR. Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay. Nature Biotechnology. PMID 26655495 DOI: 10.1038/nbt.3427  1
2015 Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, ... ... Krainer AR, et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 162: 900-10. PMID 26276636 DOI: 10.1016/j.cell.2015.07.038  1
2014 Chen HH, Welling M, Bloch DB, Muñoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N. DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells. Stem Cell Reports. 3: 892-904. PMID 25418731 DOI: 10.1016/j.stemcr.2014.09.003  1
2014 Das S, Krainer AR. Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer. Molecular Cancer Research : McR. 12: 1195-204. PMID 24807918 DOI: 10.1158/1541-7786.MCR-14-0131  1
2014 Jensen MA, Wilkinson JE, Krainer AR. Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nature Structural & Molecular Biology. 21: 189-97. PMID 24440982 DOI: 10.1038/nsmb.2756  1
2013 Sahashi K, Ling KK, Hua Y, Wilkinson JE, Nomakuchi T, Rigo F, Hung G, Xu D, Jiang YP, Lin RZ, Ko CP, Bennett CF, Krainer AR. Pathological impact of SMN2 mis-splicing in adult SMA mice. Embo Molecular Medicine. 5: 1586-601. PMID 24014320 DOI: 10.1002/emmm.201302567  1
2013 Cléry A, Sinha R, Anczuków O, Corrionero A, Moursy A, Daubner GM, Valcárcel J, Krainer AR, Allain FH. Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. Proceedings of the National Academy of Sciences of the United States of America. 110: E2802-11. PMID 23836656 DOI: 10.1073/pnas.1303445110  1
2013 Das S, Fregoso OI, Krainer AR. A new path to oncogene-induced senescence: at the crossroads of splicing and translation. Cell Cycle (Georgetown, Tex.). 12: 1477-9. PMID 23624837 DOI: 10.4161/cc.24749  1
2013 Wu J, Anczuków O, Krainer AR, Zhang MQ, Zhang C. OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acids Research. 41: 5149-63. PMID 23571760 DOI: 10.1093/nar/gkt216  1
2013 Fregoso OI, Das S, Akerman M, Krainer AR. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Molecular Cell. 50: 56-66. PMID 23478443 DOI: 10.1016/j.molcel.2013.02.001  1
2013 Roca X, Krainer AR, Eperon IC. Pick one, but be quick: 5' splice sites and the problems of too many choices. Genes & Development. 27: 129-44. PMID 23348838 DOI: 10.1101/gad.209759.112  1
2013 Ben-Hur V, Denichenko P, Siegfried Z, Maimon A, Krainer A, Davidson B, Karni R. S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1 Cell Reports. 3: 103-115. PMID 23273915 DOI: 10.1016/j.celrep.2012.11.020  1
2012 Wang Z, Jeon HY, Rigo F, Bennett CF, Krainer AR. Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides. Open Biology. 2: 120133. PMID 23155487 DOI: 10.1098/rsob.120133  1
2012 Rigo F, Hua Y, Krainer AR, Bennett CF. Antisense-based therapy for the treatment of spinal muscular atrophy. The Journal of Cell Biology. 199: 21-5. PMID 23027901 DOI: 10.1083/jcb.201207087  1
2012 Sahashi K, Hua Y, Ling KK, Hung G, Rigo F, Horev G, Katsuno M, Sobue G, Ko CP, Bennett CF, Krainer AR. TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals. Genes & Development. 26: 1874-84. PMID 22895255 DOI: 10.1101/gad.197418.112  1
2012 Beaulieu CL, Samuels ME, Ekins S, McMaster CR, Edwards AM, Krainer AR, Hicks GG, Frey BJ, Boycott KM, Mackenzie AE. A generalizable pre-clinical research approach for orphan disease therapy. Orphanet Journal of Rare Diseases. 7: 39. PMID 22704758 DOI: 10.1186/1750-1172-7-39  1
2012 Roca X, Akerman M, Gaus H, Berdeja A, Bennett CF, Krainer AR. Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides. Genes & Development. 26: 1098-109. PMID 22588721 DOI: 10.1101/gad.190173.112  1
2012 Das S, Anczuków O, Akerman M, Krainer AR. Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Reports. 1: 110-7. PMID 22545246 DOI: 10.1016/j.celrep.2011.12.001  1
2012 Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR, Bennett CF. Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. Nature Chemical Biology. 8: 555-61. PMID 22504300 DOI: 10.1038/nchembio.939  1
2012 Hua Y, Krainer AR. Antisense-mediated exon inclusion. Methods in Molecular Biology (Clifton, N.J.). 867: 307-23. PMID 22454070 DOI: 10.1007/978-1-61779-767-5_20  1
2012 Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural & Molecular Biology. 19: 220-8. PMID 22245967 DOI: 10.1038/nsmb.2207  1
2012 Sun S, Zhang Z, Fregoso O, Krainer AR. Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. Rna (New York, N.Y.). 18: 274-83. PMID 22184459 DOI: 10.1261/rna.030486.111  1
2012 Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology. 4: 79-87. PMID 22044881 DOI: 10.1093/jmcb/mjr030  1
2012 Mayeda A, Krainer AR. In Vitro Splicing Assays Alternative Pre-Mrna Splicing: Theory and Protocols. 320-329. DOI: 10.1002/9783527636778.ch30  1
2011 Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR. Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature. 478: 123-6. PMID 21979052 DOI: 10.1038/nature10485  1
2011 Wu J, Akerman M, Sun S, McCombie WR, Krainer AR, Zhang MQ. SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics (Oxford, England). 27: 3010-6. PMID 21896509 DOI: 10.1093/bioinformatics/btr508  1
2011 Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: 8233-8. PMID 21536904 DOI: 10.1073/pnas.1017700108  1
2011 Kubota T, Roca X, Kimura T, Kokunai Y, Nishino I, Sakoda S, Krainer AR, Takahashi MP. A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia. Human Mutation. 32: 773-82. PMID 21412952 DOI: 10.1002/humu.21501  1
2011 Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH. Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy. Science Translational Medicine. 3: 72ra18. PMID 21368223 DOI: 10.1126/scitranslmed.3001777  1
2011 Thorsen K, Mansilla F, Schepeler T, Øster B, Rasmussen MH, Dyrskjøt L, Karni R, Akerman M, Krainer AR, Laurberg S, Andersen CL, Ørntoft TF. Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. Molecular & Cellular Proteomics : McP. 10: M110.002998. PMID 20938052 DOI: 10.1074/mcp.M110.002998  1
2010 Hua Y, Sahashi K, Hung G, Rigo F, Passini MA, Bennett CF, Krainer AR. Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes & Development. 24: 1634-44. PMID 20624852 DOI: 10.1101/gad.1941310  1
2010 Manley JL, Krainer AR. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes & Development. 24: 1073-4. PMID 20516191 DOI: 10.1101/gad.1934910  1
2010 Wu H, Sun S, Tu K, Gao Y, Xie B, Krainer AR, Zhu J. A splicing-independent function of SF2/ASF in microRNA processing. Molecular Cell. 38: 67-77. PMID 20385090 DOI: 10.1016/j.molcel.2010.02.021  1
2010 Sinha R, Allemand E, Zhang Z, Karni R, Myers MP, Krainer AR. Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF. Molecular and Cellular Biology. 30: 2762-74. PMID 20308322 DOI: 10.1128/MCB.01270-09  1
2010 Sun S, Zhang Z, Sinha R, Karni R, Krainer AR. SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nature Structural & Molecular Biology. 17: 306-12. PMID 20139984 DOI: 10.1038/nsmb.1750  1
2010 Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 1894-9. PMID 20133837 DOI: 10.1073/pnas.0914845107  1
2009 Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Science Translational Medicine. 1: 5ra12. PMID 20161659 DOI: 10.1126/scitranslmed.3000208  1
2009 Khoo B, Krainer AR. Splicing therapeutics in SMN2 and APOB. Current Opinion in Molecular Therapeutics. 11: 108-15. PMID 19330716  1
2009 Roca X, Krainer AR. A splicing component adapted to gene silencing. Nature Biotechnology. 27: 250-1. PMID 19270672 DOI: 10.1038/nbt0309-250  1
2009 Roca X, Krainer AR. Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA. Nature Structural & Molecular Biology. 16: 176-82. PMID 19169258 DOI: 10.1038/nsmb.1546  1
2008 Karni R, Hippo Y, Lowe SW, Krainer AR. The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 105: 15323-7. PMID 18832178 DOI: 10.1073/pnas.0801376105  1
2008 Zhang C, Zhang Z, Castle J, Sun S, Johnson J, Krainer AR, Zhang MQ. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes & Development. 22: 2550-63. PMID 18794351 DOI: 10.1101/gad.1703108  1
2008 Steitz JA, Dreyfuss G, Krainer AR, Lamond AI, Matera AG, Padgett RA. Where in the cell is the minor spliceosome? Proceedings of the National Academy of Sciences of the United States of America. 105: 8485-6. PMID 18562285 DOI: 10.1073/pnas.0804024105  1
2008 Chen G, Li W, Zhang QS, Regulski M, Sinha N, Barditch J, Tully T, Krainer AR, Zhang MQ, Dubnau J. Identification of synaptic targets of Drosophila pumilio. Plos Computational Biology. 4: e1000026. PMID 18463699 DOI: 10.1371/journal.pcbi.1000026  1
2008 Zhang C, Li WH, Krainer AR, Zhang MQ. RNA landscape of evolution for optimal exon and intron discrimination. Proceedings of the National Academy of Sciences of the United States of America. 105: 5797-802. PMID 18391195 DOI: 10.1073/pnas.0801692105  1
2008 Hua Y, Vickers TA, Okunola HL, Bennett CF, Krainer AR. Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. American Journal of Human Genetics. 82: 834-48. PMID 18371932 DOI: 10.1016/j.ajhg.2008.01.014  1
2008 Thorsen K, Sørensen KD, Brems-Eskildsen AS, Modin C, Gaustadnes M, Hein AM, Kruhøffer M, Laurberg S, Borre M, Wang K, Brunak S, Krainer AR, Tørring N, Dyrskjøt L, Andersen CL, et al. Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Molecular & Cellular Proteomics : McP. 7: 1214-24. PMID 18353764 DOI: 10.1074/mcp.M700590-MCP200  1
2008 Majerciak V, Yamanegi K, Allemand E, Kruhlak M, Krainer AR, Zheng ZM. Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing. Journal of Virology. 82: 2792-801. PMID 18184716 DOI: 10.1128/JVI.01856-07  1
2008 Roca X, Olson AJ, Rao AR, Enerly E, Kristensen VN, Børresen-Dale AL, Andresen BS, Krainer AR, Sachidanandam R. Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics. Genome Research. 18: 77-87. PMID 18032726 DOI: 10.1101/gr.6859308  1
2008 Zhang C, Zhang Z, Castle J, Sun S, Johnson J, Krainer AR, Zhang MQ. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2 (Genes and Development (2008) 22 (2550-2563)) Genes and Development. 22: 2902.  1
2007 Zhang C, Hastings ML, Krainer AR, Zhang MQ. Dual-specificity splice sites function alternatively as 5' and 3' splice sites. Proceedings of the National Academy of Sciences of the United States of America. 104: 15028-33. PMID 17848517 DOI: 10.1073/pnas.0703773104  1
2007 Shaw SD, Chakrabarti S, Ghosh G, Krainer AR. Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. Plos One. 2: e854. PMID 17786225 DOI: 10.1371/journal.pone.0000854  1
2007 Zhang C, Krainer AR, Zhang MQ. Evolutionary impact of limited splicing fidelity in mammalian genes. Trends in Genetics : Tig. 23: 484-8. PMID 17719121 DOI: 10.1016/j.tig.2007.08.001  1
2007 Caceres JF, Krainer AR, Kornblihtt AR. The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease. Embo Reports. 8: 730-4. PMID 17668002 DOI: 10.1038/sj.embor.7401032  1
2007 Zhang Z, Krainer AR. Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components. Proceedings of the National Academy of Sciences of the United States of America. 104: 11574-9. PMID 17606899 DOI: 10.1073/pnas.0704946104  1
2007 Das R, Yu J, Zhang Z, Gygi MP, Krainer AR, Gygi SP, Reed R. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Molecular Cell. 26: 867-81. PMID 17588520 DOI: 10.1016/j.molcel.2007.05.036  1
2007 Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). Plos One. 2: e538. PMID 17579712 DOI: 10.1371/journal.pone.0000538  1
2007 Buratti E, Chivers M, Královicová J, Romano M, Baralle M, Krainer AR, Vorechovsky I. Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization. Nucleic Acids Research. 35: 4250-63. PMID 17576681 DOI: 10.1093/nar/gkm402  1
2007 Allemand E, Hastings ML, Murray MV, Myers MP, Krainer AR. Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1. Nature Structural & Molecular Biology. 14: 630-8. PMID 17572683 DOI: 10.1038/nsmb1257  1
2007 Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR. Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. Plos Biology. 5: e73. PMID 17355180 DOI: 10.1371/journal.pbio.0050073  1
2007 Wimmer K, Roca X, Beiglböck H, Callens T, Etzler J, Rao AR, Krainer AR, Fonatsch C, Messiaen L. Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption. Human Mutation. 28: 599-612. PMID 17311297 DOI: 10.1002/humu.20493  1
2007 Karni R, de Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nature Structural & Molecular Biology. 14: 185-93. PMID 17310252 DOI: 10.1038/nsmb1209  1
2007 Nielsen KB, Sørensen S, Cartegni L, Corydon TJ, Doktor TK, Schroeder LD, Reinert LS, Elpeleg O, Krainer AR, Gregersen N, Kjems J, Andresen BS. Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. American Journal of Human Genetics. 80: 416-32. PMID 17273963 DOI: 10.1086/511992  1
2007 Khoo B, Roca X, Chew SL, Krainer AR. Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. Bmc Molecular Biology. 8: 3. PMID 17233885 DOI: 10.1186/1471-2199-8-3  1
2006 Kimura H, Takizawa N, Allemand E, Hori T, Iborra FJ, Nozaki N, Muraki M, Hagiwara M, Krainer AR, Fukagawa T, Okawa K. A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. The Journal of Cell Biology. 175: 389-400. PMID 17074886 DOI: 10.1083/jcb.200608001  1
2006 Sheth N, Roca X, Hastings ML, Roeder T, Krainer AR, Sachidanandam R. Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Research. 34: 3955-67. PMID 16914448 DOI: 10.1093/nar/gkl556  1
2006 Smith PJ, Zhang C, Wang J, Chew SL, Zhang MQ, Krainer AR. An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Human Molecular Genetics. 15: 2490-508. PMID 16825284 DOI: 10.1093/hmg/ddl171  1
2006 Zhang QS, Manche L, Xu RM, Krainer AR. hnRNP A1 associates with telomere ends and stimulates telomerase activity. Rna (New York, N.Y.). 12: 1116-28. PMID 16603717 DOI: 10.1261/rna.58806  1
2006 Cartegni L, Hastings ML, Calarco JA, de Stanchina E, Krainer AR. Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. American Journal of Human Genetics. 78: 63-77. PMID 16385450 DOI: 10.1086/498853  1
2005 Wang J, Smith PJ, Krainer AR, Zhang MQ. Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Research. 33: 5053-62. PMID 16147989 DOI: 10.1093/nar/gki810  1
2005 Tyson-Capper AJ, Bailey J, Krainer AR, Robson SC, Europe-Finner GN. The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. The Journal of Biological Chemistry. 280: 34521-9. PMID 16103121 DOI: 10.1074/jbc.M505344200  1
2005 Roca X, Sachidanandam R, Krainer AR. Determinants of the inherent strength of human 5' splice sites. Rna (New York, N.Y.). 11: 683-98. PMID 15840817 DOI: 10.1261/rna.2040605  1
2005 Allemand E, Guil S, Myers M, Moscat J, Cáceres JF, Krainer AR. Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proceedings of the National Academy of Sciences of the United States of America. 102: 3605-10. PMID 15738418 DOI: 10.1073/pnas.0409889102  1
2005 Coutinho G, Xie J, Du L, Brusco A, Krainer AR, Gatti RA. Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a. Human Mutation. 25: 118-24. PMID 15643608 DOI: 10.1002/humu.20170  1
2005 Hastings ML, Resta N, Traum D, Stella A, Guanti G, Krainer AR. An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites. Nature Structural & Molecular Biology. 12: 54-9. PMID 15608654 DOI: 10.1038/nsmb873  1
2004 Zhang Z, Krainer AR. Involvement of SR proteins in mRNA surveillance. Molecular Cell. 16: 597-607. PMID 15546619 DOI: 10.1016/j.molcel.2004.10.031  1
2004 Zatkova A, Messiaen L, Vandenbroucke I, Wieser R, Fonatsch C, Krainer AR, Wimmer K. Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1. Human Mutation. 24: 491-501. PMID 15523642 DOI: 10.1002/humu.20103  1
2004 Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M. Manipulation of alternative splicing by a newly developed inhibitor of Clks. The Journal of Biological Chemistry. 279: 24246-54. PMID 15010457 DOI: 10.1074/jbc.M314298200  1
2003 Domsic JK, Wang Y, Mayeda A, Krainer AR, Stoltzfus CM. Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. Molecular and Cellular Biology. 23: 8762-72. PMID 14612416 DOI: 10.1128/MCB.23.23.8762-8772.2003  1
2003 Roca X, Sachidanandam R, Krainer AR. Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Research. 31: 6321-33. PMID 14576320 DOI: 10.1093/nar/gkg830  1
2003 Cartegni L, Wang J, Zhu Z, Zhang MQ, Krainer AR. ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Research. 31: 3568-71. PMID 12824367 DOI: 10.1093/nar/gkg616  1
2003 Cartegni L, Krainer AR. Correction of disease-associated exon skipping by synthetic exon-specific activators. Nature Structural Biology. 10: 120-5. PMID 12524529 DOI: 10.1038/nsb887  1
2002 Hou VC, Lersch R, Gee SL, Ponthier JL, Lo AJ, Wu M, Turck CW, Koury M, Krainer AR, Mayeda A, Conboy JG. Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. The Embo Journal. 21: 6195-204. PMID 12426391 DOI: 10.1093/emboj/cdf625  1
2002 Cazalla D, Zhu J, Manche L, Huber E, Krainer AR, Cáceres JF. Nuclear export and retention signals in the RS domain of SR proteins. Molecular and Cellular Biology. 22: 6871-82. PMID 12215544 DOI: 10.1128/MCB.22.19.6871-6882.2002  1
2002 Fackenthal JD, Cartegni L, Krainer AR, Olopade OI. BRCA2 T2722R is a deleterious allele that causes exon skipping. American Journal of Human Genetics. 71: 625-31. PMID 12145750 DOI: 10.1086/342192  1
2002 Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nature Reviews. Genetics. 3: 285-98. PMID 11967553 DOI: 10.1038/nrg775  1
2002 Cartegni L, Krainer AR. Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nature Genetics. 30: 377-84. PMID 11925564 DOI: 10.1038/ng854  1
2002 Vitali J, Ding J, Jiang J, Zhang Y, Krainer AR, Xu RM. Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Research. 30: 1531-8. PMID 11917013  1
2002 Pollard AJ, Krainer AR, Robson SC, Europe-Finner GN. Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site. The Journal of Biological Chemistry. 277: 15241-51. PMID 11825891 DOI: 10.1074/jbc.M109046200  1
2002 Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. The Journal of Biological Chemistry. 277: 12703-9. PMID 11815617 DOI: 10.1074/jbc.M111337200  1
2002 Smith PJ, Spurrell EL, Coakley J, Hinds CJ, Ross RJ, Krainer AR, Chew SL. An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor. Endocrinology. 143: 146-54. PMID 11751603 DOI: 10.1210/endo.143.1.8598  1
2001 Zhu J, Mayeda A, Krainer AR. Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Molecular Cell. 8: 1351-61. PMID 11779509 DOI: 10.1016/S1097-2765(01)00409-9  1
2001 Bilodeau PS, Domsic JK, Mayeda A, Krainer AR, Stoltzfus CM. RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. Journal of Virology. 75: 8487-97. PMID 11507194 DOI: 10.1128/JVI.75.18.8487-8497.2001  1
2001 Hastings ML, Krainer AR. Pre-mRNA splicing in the new millennium. Current Opinion in Cell Biology. 13: 302-9. PMID 11343900 DOI: 10.1016/S0955-0674(00)00212-X  1
2001 Hastings ML, Krainer AR. Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. Rna (New York, N.Y.). 7: 471-82. PMID 11333026 DOI: 10.1017/S1355838201002552  1
2001 Estmer Nilsson C, Petersen-Mahrt S, Durot C, Shtrichman R, Krainer AR, Kleinberger T, Akusjärvi G. The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. The Embo Journal. 20: 864-71. PMID 11179230 DOI: 10.1093/emboj/20.4.864  1
2001 Liu HX, Cartegni L, Zhang MQ, Krainer AR. A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nature Genetics. 27: 55-8. PMID 11137998 DOI: 10.1038/83762  1
2000 Zhu J, Krainer AR. Pre-mRNA splicing in the absence of an SR protein RS domain. Genes & Development. 14: 3166-78. PMID 11124808 DOI: 10.1101/gad.189500  1
2000 Eperon IC, Makarova OV, Mayeda A, Munroe SH, Cáceres JF, Hayward DG, Krainer AR. Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Molecular and Cellular Biology. 20: 8303-18. PMID 11046128 DOI: 10.1128/MCB.20.22.8303-8318.2000  1
2000 Van Scoy S, Watakabe I, Krainer AR, Hearing J. Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. Virology. 275: 145-57. PMID 11017796 DOI: 10.1006/viro.2000.0508  1
2000 Dirksen WP, Li X, Mayeda A, Krainer AR, Rottman FM. Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. The Journal of Biological Chemistry. 275: 29170-7. PMID 10880506 DOI: 10.1074/jbc.M001126200  1
2000 Pollard AJ, Sparey C, Robson SC, Krainer AR, Europe-Finner GN. Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. The Journal of Clinical Endocrinology and Metabolism. 85: 1928-36. PMID 10843177 DOI: 10.1210/jcem.85.5.6537  1
2000 Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. The Journal of Biological Chemistry. 275: 25411-7. PMID 10827081 DOI: 10.1074/jbc.M001676200  1
2000 van der Houven van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J, Cáceres JF. The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. The Journal of Cell Biology. 149: 307-16. PMID 10769024 DOI: 10.1083/jcb.149.2.307  1
2000 Liu HX, Chew SL, Cartegni L, Zhang MQ, Krainer AR. Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Molecular and Cellular Biology. 20: 1063-71. PMID 10629063 DOI: 10.1128/MCB.20.3.1063-1071.2000  1
1999 Burns CG, Ohi R, Krainer AR, Gould KL. Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 96: 13789-94. PMID 10570151 DOI: 10.1073/pnas.96.24.13789  1
1999 Mayeda A, Krainer AR. Mammalian in vitro splicing assays. Methods in Molecular Biology (Clifton, N.J.). 118: 315-21. PMID 10549534 DOI: 10.1385/1-59259-676-2:315  1
1999 Mayeda A, Krainer AR. Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods in Molecular Biology (Clifton, N.J.). 118: 309-14. PMID 10549533 DOI: 10.1385/1-59259-676-2:309  1
1999 Chew SL, Liu HX, Mayeda A, Krainer AR. Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 96: 10655-60. PMID 10485881 DOI: 10.1073/pnas.96.19.10655  1
1999 Ismaïli N, Pérez-Morga D, Walsh P, Mayeda A, Pays A, Tebabi P, Krainer AR, Pays E. Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. Molecular and Biochemical Parasitology. 102: 103-15. PMID 10477180 DOI: 10.1016/S0166-6851(99)00091-2  1
1999 Mayeda A, Badolato J, Kobayashi R, Zhang MQ, Gardiner EM, Krainer AR. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. The Embo Journal. 18: 4560-70. PMID 10449421 DOI: 10.1093/emboj/18.16.4560  1
1999 Caputi M, Mayeda A, Krainer AR, Zahler AM. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. The Embo Journal. 18: 4060-7. PMID 10406810 DOI: 10.1093/emboj/18.14.4060  1
1999 Ding J, Hayashi MK, Zhang Y, Manche L, Krainer AR, Xu RM. Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes & Development. 13: 1102-15. PMID 10323862  1
1999 Lopato S, Kalyna M, Dorner S, Kobayashi R, Krainer AR, Barta A. atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes & Development. 13: 987-1001. PMID 10215626  1
1999 Wu Q, Krainer AR. AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Molecular and Cellular Biology. 19: 3225-36. PMID 10207048  1
1999 Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). The Journal of Biological Chemistry. 274: 11125-31. PMID 10196197 DOI: 10.1074/jbc.274.16.11125  1
1999 Jiang J, Zhang Y, Krainer AR, Xu RM. Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proceedings of the National Academy of Sciences of the United States of America. 96: 3572-7. PMID 10097078 DOI: 10.1073/pnas.96.7.3572  1
1999 Mayeda A, Screaton GR, Chandler SD, Fu XD, Krainer AR. Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Molecular and Cellular Biology. 19: 1853-63. PMID 10022872  1
1999 Murray MV, Kobayashi R, Krainer AR. The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes & Development. 13: 87-97. PMID 9887102  1
1998 Wu Q, Krainer AR. Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. Rna (New York, N.Y.). 4: 1664-73. PMID 9848661 DOI: 10.1017/S1355838298981432  1
1998 Misteli T, Cáceres JF, Clement JQ, Krainer AR, Wilkinson MF, Spector DL. Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. The Journal of Cell Biology. 143: 297-307. PMID 9786943 DOI: 10.1083/jcb.143.2.297  1
1998 Mayeda A, Munroe SH, Xu RM, Krainer AR. Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. Rna (New York, N.Y.). 4: 1111-23. PMID 9740129 DOI: 10.1017/S135583829898089X  1
1998 Liu HX, Zhang M, Krainer AR. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes & Development. 12: 1998-2012. PMID 9649504  1
1998 Hanamura A, Cáceres JF, Mayeda A, Franza BR, Krainer AR. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. Rna (New York, N.Y.). 4: 430-44. PMID 9630249  1
1998 Cáceres JF, Screaton GR, Krainer AR. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes & Development. 12: 55-66. PMID 9420331  1
1997 Jokan L, Dong AP, Mayeda A, Krainer AR, Xu RM. Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Crystallographica. Section D, Biological Crystallography. 53: 615-8. PMID 15299896 DOI: 10.1107/S0907444997003326  1
1997 Horowitz DS, Kobayashi R, Krainer AR. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. Rna (New York, N.Y.). 3: 1374-87. PMID 9404889  1
1997 Cáceres JF, Misteli T, Screaton GR, Spector DL, Krainer AR. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. The Journal of Cell Biology. 138: 225-38. PMID 9230067 DOI: 10.1083/jcb.138.2.225  1
1997 Huang S, Mayeda A, Krainer AR, Spector DL. RCC1 and nuclear organization. Molecular Biology of the Cell. 8: 1143-57. PMID 9201722  1
1997 Wu Q, Krainer AR. Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. Rna (New York, N.Y.). 3: 586-601. PMID 9174094  1
1997 Xu RM, Jokhan L, Cheng X, Mayeda A, Krainer AR. Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (London, England : 1993). 5: 559-70. PMID 9115444  1
1997 Chandler SD, Mayeda A, Yeakley JM, Krainer AR, Fu XD. RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 3596-601. PMID 9108022 DOI: 10.1073/pnas.94.8.3596  1
1997 Basu A, Dong B, Krainer AR, Howe CC. The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Molecular and Cellular Biology. 17: 677-86. PMID 9001221  1
1997 Horowitz DS, Krainer AR. A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes & Development. 11: 139-51. PMID 9000057  1
1996 Wu Q, Krainer AR. U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science (New York, N.Y.). 274: 1005-8. PMID 8875927 DOI: 10.1126/science.274.5289.1005  1
1996 Lopato S, Mayeda A, Krainer AR, Barta A. Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Proceedings of the National Academy of Sciences of the United States of America. 93: 3074-9. PMID 8610170 DOI: 10.1073/pnas.93.7.3074  1
1995 Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. The Embo Journal. 14: 4336-49. PMID 7556075  1
1994 O'Keefe RT, Mayeda A, Sadowski CL, Krainer AR, Spector DL. Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. The Journal of Cell Biology. 124: 249-60. PMID 8294510  1
1994 Huang M, Rech JE, Northington SJ, Flicker PF, Mayeda A, Krainer AR, LeStourgeon WM. The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Molecular and Cellular Biology. 14: 518-33. PMID 8264621  1
1994 Horowitz DS, Krainer AR. Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends in Genetics : Tig. 10: 100-6. PMID 8178363 DOI: 10.1016/0168-9525(94)90233-X  1
1994 Stamm S, Mulligan GJ, Krainer AR, Helfman DM. Non-radioactive detection of m3G capped RNAs by immunoblotting. Nucleic Acids Research. 22: 252-3. PMID 8121812  1
1994 Cáceres JF, Stamm S, Helfman DM, Krainer AR. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (New York, N.Y.). 265: 1706-9. PMID 8085156  1
1994 Mayeda A, Munroe SH, Cáceres JF, Krainer AR. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. The Embo Journal. 13: 5483-95. PMID 7957114  1
1993 Mayeda A, Helfman DM, Krainer AR. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Molecular and Cellular Biology. 13: 2993-3001. PMID 8474457  1
1993 Dong B, Horowitz DS, Kobayashi R, Krainer AR. Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Research. 21: 4085-92. PMID 8371983  1
1993 Birney E, Kumar S, Krainer AR. Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Research. 21: 5803-16. PMID 8290338  1
1993 Sun Q, Mayeda A, Hampson RK, Krainer AR, Rottman FM. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Development. 7: 2598-608. PMID 8276242  1
1993 Eperon IC, Ireland DC, Smith RA, Mayeda A, Krainer AR. Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. The Embo Journal. 12: 3607-17. PMID 8253084  1
1992 Mayeda A, Zahler AM, Krainer AR, Roth MB. Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 89: 1301-4. PMID 1741384  1
1992 Mayeda A, Krainer AR. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell. 68: 365-75. PMID 1531115 DOI: 10.1016/0092-8674(92)90477-T  1
1992 Fu XD, Mayeda A, Maniatis T, Krainer AR. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proceedings of the National Academy of Sciences of the United States of America. 89: 11224-8. PMID 1454802  1
1992 Birney E, Kumar S, Krainer AR. A putative homolog of U2AF65 in S. cerevisiae. Nucleic Acids Research. 20: 4663. PMID 1408772 DOI: 10.1093/nar/20.17.4663  1
1992 Amero SA, Raychaudhuri G, Cass CL, van Venrooij WJ, Habets WJ, Krainer AR, Beyer AL. Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proceedings of the National Academy of Sciences of the United States of America. 89: 8409-13. PMID 1388268  1
1991 Mayeda A, Krainer AR. Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation. Biotechniques. 10: 182. PMID 1905559  1
1991 Krainer AR, Mayeda A, Kozak D, Binns G. Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell. 66: 383-94. PMID 1830244 DOI: 10.1016/0092-8674(91)90627-B  1
1990 Krainer AR, Conway GC, Kozak D. The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell. 62: 35-42. PMID 2364434 DOI: 10.1016/0092-8674(90)90237-9  1
1990 Krainer AR, Conway GC, Kozak D. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes & Development. 4: 1158-71. PMID 2145194  1
1989 Conway GC, Krainer AR, Spector DL, Roberts RJ. Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Molecular and Cellular Biology. 9: 5273-80. PMID 2531283  1
1988 Krainer AR. Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. Nucleic Acids Research. 16: 9415-29. PMID 3141901 DOI: 10.1093/nar/16.20.9415  1
1988 Tschudi C, Krainer AR, Ullu E. The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Research. 16: 11375. PMID 3060859 DOI: 10.1093/nar/16.23.11375  1
1985 Krainer AR, Maniatis T. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell. 42: 725-36. PMID 2996774 DOI: 10.1016/0092-8674(85)90269-7  1
1984 Krainer AR, Maniatis T, Ruskin B, Green MR. Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell. 36: 993-1005. PMID 6323033 DOI: 10.1016/0092-8674(84)90049-7  1
1984 Ruskin B, Krainer AR, Maniatis T, Green MR. Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell. 38: 317-31. PMID 6088074 DOI: 10.1016/0092-8674(84)90553-1  1
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