Robert Darnell - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
Molecular Biology, Neuroscience Biology

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kobayashi M, Benakis C, Anderson C, Moore MJ, Poon C, Uekawa K, Dyke JP, Fak JJ, Mele A, Park CY, Zhou P, Anrather J, Iadecola C, Darnell RB. AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke. Cell Reports. 28: 979-991.e6. PMID 31340158 DOI: 10.1016/j.celrep.2019.06.075  0.44
2019 Zhou J, Park CY, Theesfeld CL, Wong AK, Yuan Y, Scheckel C, Fak JJ, Funk J, Yao K, Tajima Y, Packer A, Darnell RB, Troyanskaya OG. Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk. Nature Genetics. PMID 31133750 DOI: 10.1038/s41588-019-0420-0  0.44
2018 Saito Y, Yuan Y, Zucker-Scharff I, Fak JJ, Jereb S, Tajima Y, Licatalosi DD, Darnell RB. Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function. Neuron. PMID 30638744 DOI: 10.1016/j.neuron.2018.12.019  0.44
2018 Darnell JC, Mele A, Hung KYS, Darnell RB. Mapping of In Vivo RNA-Binding Sites by Ultraviolet (UV)-Cross-Linking Immunoprecipitation (CLIP). Cold Spring Harbor Protocols. 2018: pdb.top097931. PMID 30510132 DOI: 10.1101/pdb.top097931  0.4
2018 Darnell JC, Mele A, Hung KYS, Darnell RB. Isolation of the RNA Cross-Linking Immunoprecipitation (CLIP) Tags, 5'-Linker Ligation, Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Amplification, and Sequencing. Cold Spring Harbor Protocols. 2018: pdb.prot097972. PMID 30510128 DOI: 10.1101/pdb.prot097972  0.4
2018 Darnell JC, Mele A, Hung KYS, Darnell RB. 3'-Linker Ligation and Size Selection by SDS-PAGE for Cross-Linking Immunoprecipitation (CLIP). Cold Spring Harbor Protocols. 2018: pdb.prot097964. PMID 30510127 DOI: 10.1101/pdb.prot097964  0.4
2018 Darnell JC, Mele A, Hung KYS, Darnell RB. Immunoprecipitation and SDS-PAGE for Cross-Linking Immunoprecipitation (CLIP). Cold Spring Harbor Protocols. 2018: pdb.prot097956. PMID 30510126 DOI: 10.1101/pdb.prot097956  0.4
2018 Darnell JC, Mele A, Hung KYS, Darnell RB. Ultraviolet (UV) Cross-Linking of Live Cells, Lysate Preparation, and RNase Titration for Cross-Linking Immunoprecipitation (CLIP). Cold Spring Harbor Protocols. 2018: pdb.prot097949. PMID 30510125 DOI: 10.1101/pdb.prot097949  0.4
2018 Yuan Y, Xie S, Darnell JC, Darnell AJ, Saito Y, Phatnani H, Murphy EA, Zhang C, Maniatis T, Darnell RB. Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons. Genome Biology. 19: 117. PMID 30111345 DOI: 10.1186/s13059-018-1493-2  0.4
2018 Moore MJ, Blachere NE, Fak JJ, Park CY, Sawicka K, Parveen S, Zucker-Scharff I, Moltedo B, Rudensky AY, Darnell RB. ZFP36 RNA-binding proteins restrain T-cell activation and anti-viral immunity. Elife. 7. PMID 29848443 DOI: 10.7554/eLife.33057  0.44
2018 Jereb S, Hwang HW, Van Otterloo E, Govek EE, Fak JJ, Yuan Y, Hatten ME, Darnell RB. Differential 3' processing of specific transcripts expands regulatory and protein diversity across neuronal cell types. Elife. 7. PMID 29578408 DOI: 10.7554/eLife.34042  0.44
2018 Ogawa Y, Kakumoto K, Yoshida T, Kuwako KI, Miyazaki T, Yamaguchi J, Konno A, Hata J, Uchiyama Y, Hirai H, Watanabe M, Darnell RB, Okano H, Okano HJ. Elavl3 is essential for the maintenance of Purkinje neuron axons. Scientific Reports. 8: 2722. PMID 29426875 DOI: 10.1038/s41598-018-21130-5  0.4
2017 Blachère NE, Orange DE, Gantman EC, Santomasso BD, Couture GC, Ramirez-Montagut T, Fak J, O'Donovan KJ, Ru Z, Parveen S, Frank MO, Moore MJ, Darnell RB. T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy. Jci Insight. 2. PMID 29093272 DOI: 10.1172/jci.insight.96173  0.44
2017 Hwang HW, Saito Y, Park CY, Blachère NE, Tajima Y, Fak JJ, Zucker-Scharff I, Darnell RB. cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation. Neuron. 95: 1334-1349.e5. PMID 28910620 DOI: 10.1016/j.neuron.2017.08.024  0.44
2017 Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE, Darnell RB. m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Genes & Development. 31: 990-1006. PMID 28637692 DOI: 10.1101/gad.301036.117  0.44
2017 Linderman JA, Kobayashi M, Rayannavar V, Fak JJ, Darnell RB, Chao MV, Wilson AC, Mohr I. Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen. Cell Reports. 18: 1312-1323. PMID 28147283 DOI: 10.1016/j.celrep.2017.01.017  0.44
2016 Hwang JY, Lee J, Oh CK, Kang HW, Hwang IY, Um JW, Park HC, Kim S, Shin JH, Park WY, Darnell RB, Um HD, Chung KC, Kim K, Oh YJ. Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration. Cell Death & Disease. 7: e2240. PMID 27253404 DOI: 10.1038/cddis.2016.151  0.52
2016 Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z. NOVA regulate Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife. 5. PMID 27223328 DOI: 10.7554/eLife.14264  0.52
2016 Saito Y, Miranda-Rottmann S, Ruggiu M, Park CY, Fak JJ, Zhong R, Duncan JS, Fabella BA, Junge HJ, Chen Z, Araya R, Fritzsch B, Hudspeth AJ, Darnell RB. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. Elife. 5. PMID 27223325 DOI: 10.7554/eLife.14371  0.52
2016 Hwang HW, Park CY, Goodarzi H, Fak JJ, Mele A, Moore MJ, Saito Y, Darnell RB. PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage. Cell Reports. PMID 27050522 DOI: 10.1016/j.celrep.2016.03.023  0.52
2016 Scheel TK, Luna JM, Liniger M, Nishiuchi E, Rozen-Gagnon K, Shlomai A, Auray G, Gerber M, Fak J, Keller I, Bruggmann R, Darnell RB, Ruggli N, Rice CM. A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration. Cell Host & Microbe. 19: 409-423. PMID 26962949 DOI: 10.1016/j.chom.2016.02.007  0.52
2016 Moore MJ, Zhang C, Gantman EC, Mele A, Darnell JC, Darnell RB. Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nature Protocols. 11: 616. PMID 26914319 DOI: 10.1038/nprot0316-616c  0.4
2016 Scheckel C, Drapeau E, Frias MA, Park CY, Fak J, Zucker-Scharff I, Kou Y, Haroutunian V, Ma'ayan A, Buxbaum JD, Darnell RB. Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. Elife. 5. PMID 26894958 DOI: 10.7554/eLife.10421  0.52
2015 Moore MJ, Scheel TK, Luna JM, Park CY, Fak JJ, Nishiuchi E, Rice CM, Darnell RB. miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity. Nature Communications. 6: 8864. PMID 26602609 DOI: 10.1038/ncomms9864  0.52
2015 Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kuśnierczyk A, Klungland A, Darnell JE, Darnell RB. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development. PMID 26404942 DOI: 10.1101/gad.269415.115  0.52
2015 Vasilyev N, Polonskaia A, Darnell JC, Darnell RB, Patel DJ, Serganov A. Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP. Proceedings of the National Academy of Sciences of the United States of America. 112: E5391-400. PMID 26374839 DOI: 10.1073/pnas.1515737112  0.52
2015 Roberts WK, Blachère NE, Frank MO, Dousmanis A, Ransohoff RM, Darnell RB. A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. Annals of Neurology. 78: 619-29. PMID 26224283 DOI: 10.1002/ana.24494  0.52
2015 Luna JM, Scheel TK, Danino T, Shaw KS, Mele A, Fak JJ, Nishiuchi E, Takacs CN, Catanese MT, de Jong YP, Jacobson IM, Rice CM, Darnell RB. Hepatitis C virus RNA functionally sequesters miR-122. Cell. 160: 1099-110. PMID 25768906 DOI: 10.1016/j.cell.2015.02.025  0.52
2015 Cheung J, Ginter C, Cassidy M, Franklin MC, Rudolph MJ, Robine N, Darnell RB, Hendrickson WA. Structural insights into mis-regulation of protein kinase A in human tumors. Proceedings of the National Academy of Sciences of the United States of America. 112: 1374-9. PMID 25605907 DOI: 10.1073/pnas.1424206112  0.52
2015 Scheckel C, Darnell RB. Microexons--tiny but mighty. The Embo Journal. 34: 273-4. PMID 25535247 DOI: 10.15252/embj.201490651  0.52
2014 Frank MO, Kaufman J, Parveen S, Blachère NE, Orange DE, Darnell RB. Dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer. Journal of Translational Medicine. 12: 338. PMID 25475068 DOI: 10.1186/s12967-014-0338-3  0.52
2014 Blachère NE, Orange DE, Santomasso BD, Doerner J, Foo PK, Herre M, Fak J, Monette S, Gantman EC, Frank MO, Darnell RB. T cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation. European Journal of Immunology. 44: 3240-51. PMID 25103845 DOI: 10.1002/eji.201444624  0.52
2014 Vanharanta S, Marney CB, Shu W, Valiente M, Zou Y, Mele A, Darnell RB, Massagué J. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife. 3. PMID 24898756 DOI: 10.7554/eLife.02734  0.52
2014 Weyn-Vanhentenryck SM, Mele A, Yan Q, Sun S, Farny N, Zhang Z, Xue C, Herre M, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Reports. 6: 1139-52. PMID 24613350 DOI: 10.1016/j.celrep.2014.02.005  0.52
2014 Moore MJ, Zhang C, Gantman EC, Mele A, Darnell JC, Darnell RB. Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nature Protocols. 9: 263-93. PMID 24407355 DOI: 10.1038/nprot.2014.012  0.52
2013 Darnell RB. RNA protein interaction in neurons. Annual Review of Neuroscience. 36: 243-70. PMID 23701460 DOI: 10.1146/annurev-neuro-062912-114322  0.52
2013 Zhang C, Lee KY, Swanson MS, Darnell RB. Prediction of clustered RNA-binding protein motif sites in the mammalian genome. Nucleic Acids Research. 41: 6793-807. PMID 23685613 DOI: 10.1093/nar/gkt421  0.52
2013 Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB, Swanson MS. Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice. Human Molecular Genetics. 22: 3547-58. PMID 23660517 DOI: 10.1093/hmg/ddt209  0.52
2013 Younger DS, Graber J, Hayakawa-Yano Y, Parveen S, Frank M, Darnell RB. Ri/Nova gene-associated paraneoplastic subacute motor neuronopathy. Muscle & Nerve. 47: 617-8. PMID 23463350 DOI: 10.1002/mus.23783  0.52
2013 Orange DE, Blachere NE, Fak J, Parveen S, Frank MO, Herre M, Tian S, Monette S, Darnell RB. Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. Elife. 2: e00105. PMID 23390586 DOI: 10.7554/eLife.00105  0.52
2013 Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, Darnell RB. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2: e00178. PMID 23359859 DOI: 10.7554/eLife.00178  0.52
2012 Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY. Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Molecular Cell. 48: 760-70. PMID 23142080 DOI: 10.1016/j.molcel.2012.10.002  0.52
2012 Darnell R. CLIP (cross-linking and immunoprecipitation) identification of RNAs bound by a specific protein. Cold Spring Harbor Protocols. 2012: 1146-60. PMID 23118367 DOI: 10.1101/pdb.prot072132  0.52
2012 Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490: 187-91. PMID 23060188 DOI: 10.1038/nature11556  0.52
2012 Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RB. Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron. 75: 1067-80. PMID 22998874 DOI: 10.1016/j.neuron.2012.07.009  0.52
2012 Charizanis K, Lee KY, Batra R, Goodwin M, Zhang C, Yuan Y, Shiue L, Cline M, Scotti MM, Xia G, Kumar A, Ashizawa T, Clark HB, Kimura T, Takahashi MP, ... ... Darnell RB, et al. Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron. 75: 437-50. PMID 22884328 DOI: 10.1016/j.neuron.2012.05.029  0.52
2012 Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes & Development. 26: 1626-42. PMID 22802532 DOI: 10.1101/gad.191338.112  0.52
2012 Orange D, Frank M, Tian S, Dousmanis A, Marmur R, Buckley N, Parveen S, Graber JJ, Blachère N, Darnell RB. Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens. Archives of Neurology. 69: 1132-40. PMID 22566506 DOI: 10.1001/archneurol.2012.595  0.52
2012 Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee YH, Narzisi G, Leotta A, Kendall J, Grabowska E, Ma B, Marks S, Rodgers L, ... ... Darnell RB, et al. De novo gene disruptions in children on the autistic spectrum. Neuron. 74: 285-99. PMID 22542183 DOI: 10.1016/j.neuron.2012.04.009  0.52
2012 Riley KJ, Rabinowitz GS, Yario TA, Luna JM, Darnell RB, Steitz JA. EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. The Embo Journal. 31: 2207-21. PMID 22473208 DOI: 10.1038/emboj.2012.63  0.52
2012 Chi SW, Hannon GJ, Darnell RB. An alternative mode of microRNA target recognition. Nature Structural & Molecular Biology. 19: 321-7. PMID 22343717 DOI: 10.1038/nsmb.2230  0.52
2011 Darnell JC, Van Driesche SJ, Zhang C, Hung KY, Mele A, Fraser CE, Stone EF, Chen C, Fak JJ, Chi SW, Licatalosi DD, Richter JD, Darnell RB. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell. 146: 247-61. PMID 21784246 DOI: 10.1016/j.cell.2011.06.013  0.52
2011 Teplova M, Malinina L, Darnell JC, Song J, Lu M, Abagyan R, Musunuru K, Teplov A, Burley SK, Darnell RB, Patel DJ. Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1. Structure (London, England : 1993). 19: 930-44. PMID 21742260 DOI: 10.1016/j.str.2011.05.002  0.52
2011 Phan AT, Kuryavyi V, Darnell JC, Serganov A, Majumdar A, Ilin S, Raslin T, Polonskaia A, Chen C, Clain D, Darnell RB, Patel DJ. Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction. Nature Structural & Molecular Biology. 18: 796-804. PMID 21642970 DOI: 10.1038/nsmb.2064  0.52
2011 Zhang C, Darnell RB. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nature Biotechnology. 29: 607-14. PMID 21633356 DOI: 10.1038/nbt.1873  0.52
2010 Darnell RB. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdisciplinary Reviews. Rna. 1: 266-86. PMID 21935890 DOI: 10.1002/wrna.31  0.52
2010 Allen SE, Darnell RB, Lipscombe D. The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels. Channels (Austin, Tex.). 4: 483-9. PMID 21150296 DOI: 10.4161/chan.4.6.12868  0.52
2010 Frank MO, Kaufman J, Tian S, Suárez-Fariñas M, Parveen S, Blachère NE, Morris MJ, Slovin S, Scher HI, Albert ML, Darnell RB. Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer. Plos One. 5. PMID 20824184 DOI: 10.1371/journal.pone.0012367  0.52
2010 Yano M, Hayakawa-Yano Y, Mele A, Darnell RB. Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling. Neuron. 66: 848-58. PMID 20620871 DOI: 10.1016/j.neuron.2010.05.007  0.52
2010 Zhang C, Frias MA, Mele A, Ruggiu M, Eom T, Marney CB, Wang H, Licatalosi DD, Fak JJ, Darnell RB. Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science (New York, N.Y.). 329: 439-43. PMID 20558669 DOI: 10.1126/science.1191150  0.52
2010 O'Donovan KJ, Diedler J, Couture GC, Fak JJ, Darnell RB. The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells. Plos One. 5: e10045. PMID 20383333 DOI: 10.1371/journal.pone.0010045  0.52
2010 Licatalosi DD, Darnell RB. RNA processing and its regulation: global insights into biological networks. Nature Reviews. Genetics. 11: 75-87. PMID 20019688 DOI: 10.1038/nrg2673  0.52
2009 Zang JB, Nosyreva ED, Spencer CM, Volk LJ, Musunuru K, Zhong R, Stone EF, Yuva-Paylor LA, Huber KM, Paylor R, Darnell JC, Darnell RB. A mouse model of the human Fragile X syndrome I304N mutation. Plos Genetics. 5: e1000758. PMID 20011099 DOI: 10.1371/journal.pgen.1000758  0.52
2009 Darnell RB, Posner JB. Autoimmune encephalopathy: the spectrum widens. Annals of Neurology. 66: 1-2. PMID 19670434 DOI: 10.1002/ana.21759  0.52
2009 Chi SW, Zang JB, Mele A, Darnell RB. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 460: 479-86. PMID 19536157 DOI: 10.1038/nature08170  0.52
2009 Roberts WK, Deluca IJ, Thomas A, Fak J, Williams T, Buckley N, Dousmanis AG, Posner JB, Darnell RB. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. The Journal of Clinical Investigation. 119: 2042-51. PMID 19509467 DOI: 10.1172/JCI36131  0.52
2009 DeLuca I, Blachère NE, Santomasso B, Darnell RB. Tolerance to the neuron-specific paraneoplastic HuD antigen. Plos One. 4: e5739. PMID 19492067 DOI: 10.1371/journal.pone.0005739  0.52
2009 Darnell JC, Fraser CE, Mostovetsky O, Darnell RB. Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Human Molecular Genetics. 18: 3164-77. PMID 19487368 DOI: 10.1093/hmg/ddp255  0.52
2009 Ruggiu M, Herbst R, Kim N, Jevsek M, Fak JJ, Mann MA, Fischbach G, Burden SJ, Darnell RB. Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proceedings of the National Academy of Sciences of the United States of America. 106: 3513-8. PMID 19221030 DOI: 10.1073/pnas.0813112106  0.52
2008 Jensen KB, Darnell RB. CLIP: crosslinking and immunoprecipitation of in vivo RNA targets of RNA-binding proteins. Methods in Molecular Biology (Clifton, N.J.). 488: 85-98. PMID 18982285 DOI: 10.1007/978-1-60327-475-3_6  0.52
2008 Licatalosi DD, Mele A, Fak JJ, Ule J, Kayikci M, Chi SW, Clark TA, Schweitzer AC, Blume JE, Wang X, Darnell JC, Darnell RB. HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature. 456: 464-9. PMID 18978773 DOI: 10.1038/nature07488  0.52
2007 Ule J, Darnell RB. Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain. Advances in Experimental Medicine and Biology. 623: 148-60. PMID 18380345  0.52
2007 Santomasso BD, Roberts WK, Thomas A, Williams T, Blachère NE, Dudley ME, Houghton AN, Posner JB, Darnell RB. A T-cell receptor associated with naturally occurring human tumor immunity. Proceedings of the National Academy of Sciences of the United States of America. 104: 19073-8. PMID 18045792 DOI: 10.1073/pnas.0704336104  0.52
2007 Jelen N, Ule J, Zivin M, Darnell RB. Evolution of Nova-dependent splicing regulation in the brain. Plos Genetics. 3: 1838-47. PMID 17937501 DOI: 10.1371/journal.pgen.0030173  0.52
2007 Darnell RB. NMDA receptor as a target in paraneoplastic encephalitis. Annals of Neurology. 61: 3-4. PMID 17262845 DOI: 10.1002/ana.21074  0.52
2007 Longman RS, Braun D, Pellegrini S, Rice CM, Darnell RB, Albert ML. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood. 109: 1113-22. PMID 17018853 DOI: 10.1182/blood-2006-05-023465  0.52
2006 Darnell RB. Developing global insight into RNA regulation. Cold Spring Harbor Symposia On Quantitative Biology. 71: 321-7. PMID 17381312 DOI: 10.1101/sqb.2006.71.002  0.52
2006 Ule J, Stefani G, Mele A, Ruggiu M, Wang X, Taneri B, Gaasterland T, Blencowe BJ, Darnell RB. An RNA map predicting Nova-dependent splicing regulation. Nature. 444: 580-6. PMID 17065982 DOI: 10.1038/nature05304  0.52
2006 Licatalosi DD, Darnell RB. Splicing regulation in neurologic disease. Neuron. 52: 93-101. PMID 17015229 DOI: 10.1016/j.neuron.2006.09.017  0.52
2006 Darnell RB, Posner JB. Paraneoplastic syndromes affecting the nervous system. Seminars in Oncology. 33: 270-98. PMID 16769417 DOI: 10.1053/j.seminoncol.2006.03.008  0.52
2006 Blachère NE, Morris HK, Braun D, Saklani H, Di Santo JP, Darnell RB, Albert ML. IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation. Journal of Immunology (Baltimore, Md. : 1950). 176: 7288-300. PMID 16751372  0.52
2006 Ule J, Darnell RB. RNA binding proteins and the regulation of neuronal synaptic plasticity. Current Opinion in Neurobiology. 16: 102-10. PMID 16418001 DOI: 10.1016/j.conb.2006.01.003  0.52
2005 Ule J, Jensen K, Mele A, Darnell RB. CLIP: a method for identifying protein-RNA interaction sites in living cells. Methods (San Diego, Calif.). 37: 376-86. PMID 16314267 DOI: 10.1016/j.ymeth.2005.07.018  0.52
2005 Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, Jan LY. Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell. 123: 105-18. PMID 16213216 DOI: 10.1016/j.cell.2005.07.033  0.52
2005 Darnell JC, Mostovetsky O, Darnell RB. FMRP RNA targets: identification and validation. Genes, Brain, and Behavior. 4: 341-9. PMID 16098133 DOI: 10.1111/j.1601-183X.2005.00144.x  0.52
2005 Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, Wang H, Clark T, Fraser C, Ruggiu M, Zeeberg BR, Kane D, Weinstein JN, Blume J, Darnell RB. Nova regulates brain-specific splicing to shape the synapse. Nature Genetics. 37: 844-52. PMID 16041372 DOI: 10.1038/ng1610  0.52
2005 Darnell RB, Posner JB. A new cause of limbic encephalopathy. Brain : a Journal of Neurology. 128: 1745-6. PMID 16030181 DOI: 10.1093/brain/awh592  0.52
2005 Dredge BK, Stefani G, Engelhard CC, Darnell RB. Nova autoregulation reveals dual functions in neuronal splicing. The Embo Journal. 24: 1608-20. PMID 15933722 DOI: 10.1038/sj.emboj.7600630  0.52
2005 Blachère NE, Darnell RB, Albert ML. Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. Plos Biology. 3: e185. PMID 15839733 DOI: 10.1371/journal.pbio.0030185  0.52
2005 Darnell JC, Fraser CE, Mostovetsky O, Stefani G, Jones TA, Eddy SR, Darnell RB. Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes & Development. 19: 903-18. PMID 15805463 DOI: 10.1101/gad.1276805  0.52
2005 Relógio A, Ben-Dov C, Baum M, Ruggiu M, Gemund C, Benes V, Darnell RB, Valcárcel J. Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells. The Journal of Biological Chemistry. 280: 4779-84. PMID 15546866 DOI: 10.1074/jbc.M411976200  0.52
2004 Musunuru K, Darnell RB. Determination and augmentation of RNA sequence specificity of the Nova K-homology domains Nucleic Acids Research. 32: 4852-4861. PMID 15367696 DOI: 10.1093/nar/gkh799  0.52
2004 Roberts WK, Darnell RB. Neuroimmunology of the paraneoplastic neurological degenerations Current Opinion in Immunology. 16: 616-622. PMID 15342008 DOI: 10.1016/j.coi.2004.07.009  0.52
2004 Stefani G, Fraser CE, Darnell JC, Darnell RB. Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells Journal of Neuroscience. 24: 7272-7276. PMID 15317853 DOI: 10.1523/JNEUROSCI.2306-04.2004  0.52
2004 Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, Sakaguchi M, Darnell RB, Okano HJ, Okano H. Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neuroscience Letters. 358: 157-60. PMID 15039105 DOI: 10.1016/j.neulet.2004.01.026  0.52
2004 Orange DE, Jegathesan M, Blachère NE, Frank MO, Scher HI, Albert ML, Darnell RB. Effective antigen cross-presentation by prostate cancer patients' dendritic cells: implications for prostate cancer immunotherapy. Prostate Cancer and Prostatic Diseases. 7: 63-72. PMID 14999241 DOI: 10.1038/sj.pcan.4500694  0.52
2004 Darnell JC, Warren ST, Darnell RB. The Fragile X Mental Retardation Protein, FMRP, Recognizes G-Quartets Mental Retardation and Developmental Disabilities Research Reviews. 10: 49-52. PMID 14994288 DOI: 10.1002/mrdd.20008  0.52
2004 Darnell R. Tumor immunity in small-cell lung cancer Journal of Clinical Oncology. 22: 762-764. PMID 14990628 DOI: 10.1200/JCO.2004.12.936  0.52
2004 Darnell RB. Paraneoplastic Neurologic Disorders: Windows into Neuronal Function and Tumor Immunity Archives of Neurology. 61: 30-32. PMID 14732616 DOI: 10.1001/archneur.61.1.30  0.52
2004 Albert ML, Darnell RB. Paraneoplastic neurological degenerations: Keys to tumour immunity Nature Reviews Cancer. 4: 36-44. PMID 14708025  0.52
2003 Darnell RB. Memory, Synaptic Translation, and...Prions? Cell. 115: 767-768. PMID 14697195 DOI: 10.1016/S0092-8674(03)01022-5  0.52
2003 Ule J, Jensen KB, Ruggiu M, Mele A, Ule A, Darnell RB. CLIP identifies Nova-regulated RNA networks in the brain. Science (New York, N.Y.). 302: 1212-5. PMID 14615540 DOI: 10.1126/science.1090095  0.52
2003 Dredge BK, Darnell RB. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Molecular and Cellular Biology. 23: 4687-700. PMID 12808107 DOI: 10.1128/MCB.23.13.4687-4700.2003  0.52
2003 Darnell RB, Posner JB. Observing the invisible: successful tumor immunity in humans. Nature Immunology. 4: 201. PMID 12605223 DOI: 10.1038/ni0303-201  0.52
2003 Farina KL, Huttelmaier S, Musunuru K, Darnell R, Singer RH. Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment. The Journal of Cell Biology. 160: 77-87. PMID 12507992 DOI: 10.1083/jcb.200206003  0.52
2002 Darnell RB. RNA logic in time and space Cell. 110: 545-550. PMID 12230972 DOI: 10.1016/S0092-8674(02)00937-6  0.52
2002 Ito M, Okano HJ, Darnell RB, Roeder RG. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development Embo Journal. 21: 3464-3475. PMID 12093747 DOI: 10.1093/emboj/cdf348  0.52
2000 Polydorides AD, Okano HJ, Yang YY, Stefani G, Darnell RB. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proceedings of the National Academy of Sciences of the United States of America. 97: 6350-5. PMID 10829067 DOI: 10.1073/pnas.110128397  0.52
2000 Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ, Yang YY, Darnell RB. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron. 25: 359-71. PMID 10719891  0.52
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