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Ali Salahpour - Publications

Pharmacology and Toxicology University of Toronto, Toronto, ON, Canada 

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lipina T, Men X, Blundell M, Salahpour A, Ramsey AJ. Abnormal sensory perception masks behavioral performance of Grin1 knockdown mice. Genes, Brain, and Behavior. e12825. PMID 35705513 DOI: 10.1111/gbb.12825  0.648
2022 Sutton C, Williams EQ, Homsi H, Beerepoot P, Nazari R, Han D, Ramsey AJ, Mash DC, Olson DE, Blough B, Salahpour A. Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones. Frontiers in Cellular Neuroscience. 16: 832536. PMID 35614973 DOI: 10.3389/fncel.2022.832536  0.669
2021 Vecchio LM, Sullivan P, Dunn AR, Bermejo MK, Fu R, Masoud ST, Gregersen E, Urs NM, Nazari R, Jensen PH, Ramsey A, Goldstein DS, Miller GW, Salahpour A. Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo. Journal of Neurochemistry. PMID 33991113 DOI: 10.1111/jnc.15432  0.716
2020 Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, et al. A novel allosteric modulator of the cannabinoid CB receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 33036015 DOI: 10.1038/s41386-020-00876-5  0.709
2020 Mielnik CA, Binko MA, Chen Y, Funk AJ, Johansson EM, Intson K, Sivananthan N, Islam R, Milenkovic M, Horsfall W, Ross RA, Groc L, Salahpour A, McCullumsmith RE, Tripathy S, et al. Consequences of NMDA receptor deficiency can be rescued in the adult brain. Molecular Psychiatry. PMID 32807843 DOI: 10.1038/S41380-020-00859-4  0.688
2019 Intson K, van Eede MC, Islam R, Milenkovic M, Yan Y, Salahpour A, Henkelman RM, Ramsey AJ. Progressive neuroanatomical changes caused by Grin1 loss-of-function mutation. Neurobiology of Disease. 104527. PMID 31299220 DOI: 10.1016/J.Nbd.2019.104527  0.686
2018 Chen Y, Milenkovic M, Horsfall W, Salahpour A, Soderling SH, Ramsey AJ. Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. Plos One. 13: e0199341. PMID 30352064 DOI: 10.1371/Journal.Pone.0199341  0.667
2018 Lam VM, Mielnik CA, Baimel C, Beerepoot P, Espinoza S, Sukhanov I, Horsfall W, Gainetdinov RR, Borgland SL, Ramsey AJ, Salahpour A. Behavioral Effects of a Potential Novel TAAR1 Antagonist. Frontiers in Pharmacology. 9: 953. PMID 30233365 DOI: 10.3389/Fphar.2018.00953  0.713
2017 Islam R, Trépanier MO, Milenkovic M, Horsfall W, Salahpour A, Bazinet RP, Ramsey AJ. Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction. Npj Schizophrenia. 3: 12. PMID 28560258 DOI: 10.1038/s41537-017-0014-8  0.646
2016 Beerepoot P, Nazari R, Salahpour A. Pharmacological chaperone approaches for rescuing GPCR mutants: Current state, challenges, and screening strategies. Pharmacological Research. PMID 28027910 DOI: 10.1016/j.phrs.2016.12.036  0.327
2016 Beerepoot P, Lam VM, Salahpour A. Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. The Journal of Biological Chemistry. PMID 27555326 DOI: 10.1074/Jbc.M116.749119  0.401
2016 Lohr KM, Masoud ST, Salahpour A, Miller GW. Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease. The European Journal of Neuroscience. PMID 27520881 DOI: 10.1111/Ejn.13357  0.556
2015 Lam VM, Espinoza S, Gerasimov AS, Gainetdinov RR, Salahpour A. In-vivo pharmacology of Trace-Amine Associated Receptor 1. European Journal of Pharmacology. PMID 26093041 DOI: 10.1016/J.Ejphar.2015.06.026  0.491
2015 Lohr KM, Stout KA, Dunn AR, Wang M, Salahpour A, Guillot TS, Miller GW. Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. Acs Chemical Neuroscience. 6: 790-9. PMID 25746685 DOI: 10.1021/Acschemneuro.5B00010  0.565
2015 Beerepoot P, Lam VM, Salahpour A. A β-lactamase based assay to measure surface expression of membrane proteins. Methods in Molecular Biology (Clifton, N.J.). 1270: 107-14. PMID 25702112 DOI: 10.1007/978-1-4939-2309-0_8  0.304
2015 Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, ... ... Salahpour A, et al. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. Neurobiology of Disease. 74: 66-75. PMID 25447236 DOI: 10.1016/J.Nbd.2014.10.016  0.555
2015 Lam VM, Rodríguez D, Zhang T, Koh EJ, Carlsson J, Salahpour A. Discovery of trace amine-associated receptor 1 ligands by molecular docking screening against a homology model Medchemcomm. 6: 2216-2223. DOI: 10.1039/C5Md00400D  0.436
2014 Bermejo MK, Milenkovic M, Salahpour A, Ramsey AJ. Preparation of synaptic plasma membrane and postsynaptic density proteins using a discontinuous sucrose gradient. Journal of Visualized Experiments : Jove. e51896. PMID 25226023 DOI: 10.3791/51896  0.641
2014 Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Wang M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, et al. Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 9977-82. PMID 24979780 DOI: 10.1073/Pnas.1402134111  0.557
2014 Vecchio LM, Bermejo MK, Beerepoot P, Ramsey AJ, Salahpour A. N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo. Molecular and Cellular Neurosciences. 61: 123-32. PMID 24886986 DOI: 10.1016/J.Mcn.2014.05.007  0.707
2014 Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addiction Biology. 19: 145-55. PMID 22458761 DOI: 10.1111/J.1369-1600.2012.00456.X  0.494
2014 Calipari E, Ferris M, Salahpour A, Caron M, Roberts D, Jones S. Methylphenidate self-administration increases the potency and reinforcing effects of releasers through a dopamine transporter mechanism Drug and Alcohol Dependence. 140: e24-e25. DOI: 10.1016/J.Drugalcdep.2014.02.088  0.582
2013 Medvedev IO, Ramsey AJ, Masoud ST, Bermejo MK, Urs N, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Salahpour A. D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18125-33. PMID 24227722 DOI: 10.1523/Jneurosci.2382-13.2013  0.785
2013 Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nature Communications. 4: 2720. PMID 24193139 DOI: 10.1038/Ncomms3720  0.604
2013 Lam VM, Beerepoot P, Angers S, Salahpour A. A novel assay for measurement of membrane-protein surface expression using a β-lactamase. Traffic (Copenhagen, Denmark). 14: 778-84. PMID 23574269 DOI: 10.1111/Tra.12073  0.625
2013 Beerepoot P, Lam VM, Salahpour A. Measurement of G protein-coupled receptor surface expression. Journal of Receptor and Signal Transduction Research. 33: 162-5. PMID 23557016 DOI: 10.3109/10799893.2013.781625  0.456
2013 Espinoza S, Masri B, Salahpour A, Gainetdinov RR. BRET approaches to characterize dopamine and TAAR1 receptor pharmacology and signaling. Methods in Molecular Biology (Clifton, N.J.). 964: 107-22. PMID 23296781 DOI: 10.1007/978-1-62703-251-3_8  0.516
2012 Salahpour A, Espinoza S, Masri B, Lam V, Barak LS, Gainetdinov RR. BRET biosensors to study GPCR biology, pharmacology, and signal transduction. Frontiers in Endocrinology. 3: 105. PMID 22952466 DOI: 10.3389/Fendo.2012.00105  0.478
2012 Kile BM, Walsh PL, McElligott ZA, Bucher ES, Guillot TS, Salahpour A, Caron MG, Wightman RM. Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry. Acs Chemical Neuroscience. 3: 285-292. PMID 22708011 DOI: 10.1021/Cn200119U  0.49
2012 Managò F, Espinoza S, Salahpour A, Sotnikova TD, Caron MG, Premont RT, Gainetdinov RR. The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment. Scientific Reports. 2: 301. PMID 22393477 DOI: 10.1038/Srep00301  0.554
2012 Salahpour A, Caron MG. Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite. Neuron. 73: 210-1. PMID 22284175 DOI: 10.1016/J.Neuron.2012.01.004  0.624
2011 Salahpour A, Barak LS. Visualizing receptor endocytosis and trafficking. Methods in Molecular Biology (Clifton, N.J.). 756: 311-23. PMID 21870235 DOI: 10.1007/978-1-61779-160-4_18  0.484
2011 Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, Caron MG, Gainetdinov RR. Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Molecular Pharmacology. 80: 416-25. PMID 21670104 DOI: 10.1124/Mol.111.073304  0.65
2011 Ramsey AJ, Milenkovic M, Oliveira AF, Escobedo-Lozoya Y, Seshadri S, Salahpour A, Sawa A, Yasuda R, Caron MG. Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 108: 5795-800. PMID 21436042 DOI: 10.1073/Pnas.1012621108  0.74
2010 Sotnikova TD, Beaulieu JM, Espinoza S, Masri B, Zhang X, Salahpour A, Barak LS, Caron MG, Gainetdinov RR. The dopamine metabolite 3-methoxytyramine is a neuromodulator. Plos One. 5: e13452. PMID 20976142 DOI: 10.1371/Journal.Pone.0013452  0.694
2010 Dzirasa K, Phillips HW, Sotnikova TD, Salahpour A, Kumar S, Gainetdinov RR, Caron MG, Nicolelis MA. Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6387-97. PMID 20445065 DOI: 10.1523/Jneurosci.0764-10.2010  0.473
2010 Sotnikova TD, Beaulieu J, Espinoza S, Masri B, Zhang X, Salahpour A, Barak LS, Caron MG, Gainetdinov RR. Correction: The Dopamine Metabolite 3-Methoxytyramine Is a Neuromodulator Plos One. 5. DOI: 10.1371/Annotation/A2019934-B1Cc-4781-80Cb-9E09Fc7Ff6Dc  0.448
2009 Ghisi V, Ramsey AJ, Masri B, Gainetdinov RR, Caron MG, Salahpour A. Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cellular Signalling. 21: 87-94. PMID 18929645 DOI: 10.1016/J.Cellsig.2008.09.011  0.773
2008 Masri B, Salahpour A, Didriksen M, Ghisi V, Beaulieu JM, Gainetdinov RR, Caron MG. Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics. Proceedings of the National Academy of Sciences of the United States of America. 105: 13656-61. PMID 18768802 DOI: 10.1073/Pnas.0803522105  0.672
2008 Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR. Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Molecular Pharmacology. 74: 585-94. PMID 18524885 DOI: 10.1124/Mol.108.048884  0.782
2008 Salahpour A, Ramsey AJ, Medvedev IO, Kile B, Sotnikova TD, Holmstrand E, Ghisi V, Nicholls PJ, Wong L, Murphy K, Sesack SR, Wightman RM, Gainetdinov RR, Caron MG. Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. 105: 4405-10. PMID 18347339 DOI: 10.1073/Pnas.0707646105  0.773
2008 Ramsey AJ, Laakso A, Cyr M, Sotnikova TD, Salahpour A, Medvedev IO, Dykstra LA, Gainetdinov RR, Caron MG. Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2701-14. PMID 18185498 DOI: 10.1038/Sj.Npp.1301663  0.748
2008 Caron M, Masri B, Beaulieu J, Salahpour A, Ramsey A, Sotnikova T, Gainetdinov R. S.20.03 β-Arrestin-dependent DAD2R/Akt/GSK3β signaling: relationship to mood stabilisers and antipsychotics European Neuropsychopharmacology. 18: S184. DOI: 10.1016/S0924-977X(08)70190-1  0.654
2007 Beaulieu JM, Tirotta E, Sotnikova TD, Masri B, Salahpour A, Gainetdinov RR, Borrelli E, Caron MG. Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 881-5. PMID 17251429 DOI: 10.1523/Jneurosci.5074-06.2007  0.704
2007 Salahpour A, Medvedev IO, Beaulieu JM, Gainetdinov RR, Caron MG. Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals. Biological Psychiatry. 61: 65-9. PMID 16712807 DOI: 10.1016/J.Biopsych.2006.03.020  0.629
2006 Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Molecular and Cellular Biology. 26: 7550-60. PMID 16908539 DOI: 10.1128/Mcb.00546-06  0.626
2006 Bernier V, Morello JP, Zarruk A, Debrand N, Salahpour A, Lonergan M, Arthus MF, Laperrière A, Brouard R, Bouvier M, Bichet DG. Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus. Journal of the American Society of Nephrology : Jasn. 17: 232-43. PMID 16319185 DOI: 10.1681/Asn.2005080854  0.783
2004 Salahpour A, Angers S, Mercier JF, Lagacé M, Marullo S, Bouvier M. Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting. The Journal of Biological Chemistry. 279: 33390-7. PMID 15155738 DOI: 10.1074/Jbc.M403363200  0.818
2003 Salahpour A, Bonin H, Bhalla S, Petäjä-Repo U, Bouvier M. Biochemical characterization of beta2-adrenergic receptor dimers and oligomers. Biological Chemistry. 384: 117-23. PMID 12674505 DOI: 10.1515/Bc.2003.012  0.781
2002 Mercier JF, Salahpour A, Angers S, Breit A, Bouvier M. Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. The Journal of Biological Chemistry. 277: 44925-31. PMID 12244098 DOI: 10.1074/Jbc.M205767200  0.8
2002 Lavoie C, Mercier JF, Salahpour A, Umapathy D, Breit A, Villeneuve LR, Zhu WZ, Xiao RP, Lakatta EG, Bouvier M, Hébert TE. Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy. The Journal of Biological Chemistry. 277: 35402-10. PMID 12140284 DOI: 10.1074/Jbc.M204163200  0.784
2002 Angers S, Salahpour A, Bouvier M. Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annual Review of Pharmacology and Toxicology. 42: 409-35. PMID 11807178 DOI: 10.1146/Annurev.Pharmtox.42.091701.082314  0.75
2001 Morello JP, Salahpour A, Petäjä-Repo UE, Laperrière A, Lonergan M, Arthus MF, Nabi IR, Bichet DG, Bouvier M. Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus. Biochemistry. 40: 6766-75. PMID 11389590 DOI: 10.1021/Bi002699R  0.805
2001 Angers S, Salahpour A, Bouvier M. Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells. Life Sciences. 68: 2243-50. PMID 11358333 DOI: 10.1016/S0024-3205(01)01012-8  0.758
2000 Salahpour A, Angers S, Bouvier M. Functional significance of oligomerization of G-protein-coupled receptors. Trends in Endocrinology and Metabolism: Tem. 11: 163-8. PMID 10856916 DOI: 10.1016/S1043-2760(00)00260-5  0.734
2000 Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M. Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. The Journal of Clinical Investigation. 105: 887-95. PMID 10749568 DOI: 10.1172/Jci8688  0.776
2000 Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, Bouvier M. Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proceedings of the National Academy of Sciences of the United States of America. 97: 3684-9. PMID 10725388 DOI: 10.1073/Pnas.97.7.3684  0.804
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