Akira Sawa - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Mental Health

300 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim SH, Zoubovsky S, Hirota-Tsuyada Y, Zala D, Bruyere J, Katz BM, Huang B, Flores R, Narayan S, Hou Z, Economides AN, ... ... Sawa A, et al. Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. Molecular Psychiatry. PMID 35165396 DOI: 10.1038/s41380-021-01389-3  0.799
2021 Namkung H, Thomas KL, Hall J, Sawa A. Parsing neural circuits of fear learning and extinction across basic and clinical neuroscience: towards better translation. Neuroscience and Biobehavioral Reviews. PMID 34921863 DOI: 10.1016/j.neubiorev.2021.12.025  0.627
2021 Xiao MF, Roh SE, Zhou J, Chien CC, Lucey BP, Craig MT, Hayes LN, Coughlin JM, Leweke FM, Jia M, Xu D, Zhou W, Conover Talbot C, Arnold DB, Staley M, ... ... Sawa A, et al. A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function. Science Advances. 7: eabf6935. PMID 34818031 DOI: 10.1126/sciadv.abf6935  0.77
2021 Etyemez S, Narita Z, Mihaljevic M, Ishizuka K, Kamath V, Yang K, Sawa A. Olfactory dysfunction and face processing of social cognition in first-episode psychosis. Neuroscience Research. PMID 34655664 DOI: 10.1016/j.neures.2021.10.003  0.474
2021 Narita Z, Yang K, Kuga H, Piancharoen P, Etyemez S, Faria A, Mihaljevic M, Longo L, Namkung H, Coughlin JM, Nestadt G, Nucifora FC, Sedlak TW, Schaub R, Crawford J, ... ... Sawa A, et al. Face processing of social cognition in patients with first episode psychosis: Its deficits and association with the right subcallosal anterior cingulate cortex. Schizophrenia Research. 238: 99-107. PMID 34649085 DOI: 10.1016/j.schres.2021.09.027  0.781
2021 Yang K, Longo L, Narita Z, Cascella N, Nucifora FC, Coughlin JM, Nestadt G, Sedlak TW, Mihaljevic M, Wang M, Kenkare A, Nagpal A, Sethi M, Kelly A, Di Carlo P, ... ... Sawa A, et al. A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance. Molecular Psychiatry. PMID 34642460 DOI: 10.1038/s41380-021-01331-7  0.629
2021 Kulason S, Ratnanather JT, Miller MI, Kamath V, Hua J, Yang K, Ma M, Ishizuka K, Sawa A. A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease. Seminars in Cell & Developmental Biology. PMID 34462249 DOI: 10.1016/j.semcdb.2021.08.009  0.52
2021 Fu X, Shah AP, Keighron J, Mou TM, Ladenheim B, Alt J, Fukudome D, Niwa M, Tamashiro KL, Tanda G, Sawa A, Cadet JL, Rais R, Baraban JM. Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity. Translational Psychiatry. 11: 427. PMID 34392304 DOI: 10.1038/s41398-021-01547-9  0.647
2021 Yang K, Hua J, Etyemez S, Paez A, Prasad N, Ishizuka K, Sawa A, Kamath V. Volumetric alteration of olfactory bulb and immune-related molecular changes in olfactory epithelium in first episode psychosis patients. Schizophrenia Research. 235: 9-11. PMID 34280869 DOI: 10.1016/j.schres.2021.07.016  0.446
2021 Bhattarai JP, Etyemez S, Jaaro-Peled H, Janke E, Leon Tolosa UD, Kamiya A, Gottfried JA, Sawa A, Ma M. Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition. Seminars in Cell & Developmental Biology. PMID 33975755 DOI: 10.1016/j.semcdb.2021.03.022  0.737
2021 Hasegawa Y, Namkung H, Smith A, Sakamoto S, Zhu X, Ishizuka K, Lane AP, Sawa A, Kamiya A. Causal impact of local inflammation in the nasal cavity on higher brain function and cognition. Neuroscience Research. PMID 33932551 DOI: 10.1016/j.neures.2021.04.009  0.786
2021 Merritt K, McGuire PK, Egerton A, Aleman A, Block W, Bloemen OJN, Borgan F, Bustillo JR, Capizzano AA, Coughlin JM, De la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, ... ... Sawa A, et al. Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data. Jama Psychiatry. PMID 33881460 DOI: 10.1001/jamapsychiatry.2021.0380  0.641
2021 Kano SI, Yang K, Sawa A. Making Sense of Extracellular Vesicles in Body Fluids: Promise and Challenge. Schizophrenia Bulletin. PMID 33748856 DOI: 10.1093/schbul/sbab009  0.627
2021 Li T, Ning B, Kong L, Dai B, He X, Thomas JM, Sawa A, Ross CA, Smith WW. A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts. Cells. 10. PMID 33672296 DOI: 10.3390/cells10020480  0.407
2021 Mejias R, Rodriguez-Gotor JJ, Niwa M, Krasnova IN, Adamczyk A, Han M, Thomas GM, Xi ZX, Huganir RL, Pletnikov MV, Sawa A, Cadet JL, Wang T. Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice. Translational Psychiatry. 11: 65. PMID 33462194 DOI: 10.1038/s41398-020-01194-6  0.648
2020 Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, ... Sawa A, et al. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Nature Communications. 11: 5903. PMID 33214552 DOI: 10.1038/s41467-020-19637-5  0.32
2020 Takayanagi Y, Ishizuka K, Laursen TM, Yukitake H, Yang K, Cascella NG, Ueda S, Sumitomo A, Narita Z, Horiuchi Y, Niwa M, Taguchi A, White MF, Eaton WW, Mortensen PB, ... ... Sawa A, et al. From population to neuron: exploring common mediators for metabolic problems and mental illnesses. Molecular Psychiatry. PMID 33173197 DOI: 10.1038/s41380-020-00939-5  0.725
2020 Coughlin JM, Yang K, Marsman A, Pradhan S, Wang M, Ward RE, Bonekamp S, Ambinder EB, Higgs CP, Kim PK, Edwards JA, Varvaris M, Wang H, Posporelis S, Ma S, ... ... Sawa A, et al. A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia. Molecular Psychiatry. PMID 33077854 DOI: 10.1038/s41380-020-00901-5  0.797
2020 Sagata N, Kano SI, Ohgidani M, Inamine S, Sakai Y, Kato H, Masuda K, Nakahara T, Nakahara-Kido M, Ohga S, Furue M, Sawa A, Kanba S, Kato TA. Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis type 1 patients. Neuropsychopharmacology Reports. PMID 33037790 DOI: 10.1002/npr2.12144  0.703
2020 Shevelkin AV, Terrillion CE, Hasegawa Y, Mychko OA, Jouroukhin Y, Sawa A, Kamiya A, Pletnikov MV. Astrocyte DISC1 contributes to cognitive function in a brain region-dependent manner. Human Molecular Genetics. PMID 32803234 DOI: 10.1093/Hmg/Ddaa180  0.601
2020 Jaaro-Peled H, Sawa A. Neurodevelopmental Factors in Schizophrenia. The Psychiatric Clinics of North America. 43: 263-274. PMID 32439021 DOI: 10.1016/J.Psc.2020.02.010  0.728
2020 Yoshihara Y, Lisi G, Yahata N, Fujino J, Matsumoto Y, Miyata J, Sugihara GI, Urayama SI, Kubota M, Yamashita M, Hashimoto R, Ichikawa N, Cahn W, van Haren NEM, Mori S, ... ... Sawa A, et al. Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity. Schizophrenia Bulletin. PMID 32300809 DOI: 10.1093/Schbul/Sbaa021  0.334
2020 Delevich K, Jaaro-Peled H, Penzo M, Sawa A, Li B. Parvalbumin interneuron dysfunction in a thalamo-prefrontal cortical circuit in locus impairment mice. Eneuro. PMID 32029441 DOI: 10.1523/ENEURO.0496-19.2020  0.705
2020 Hikida T, Yao S, Macpherson T, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A. Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex. Scientific Reports. 10: 1838. PMID 32020036 DOI: 10.1038/S41598-020-58711-2  0.553
2019 John JP, Thirunavukkarasu P, Ishizuka K, Parekh P, Sawa A. An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration. Npj Systems Biology and Applications. 5: 17. PMID 32372023 DOI: 10.1038/s41540-019-0094-3  0.509
2019 Narita Z, Stickley A, DeVylder J, Yokoi Y, Inagawa T, Yamada Y, Maruo K, Koyanagi A, Oh H, Sawa A, Sumiyoshi T. Effect of multi-session prefrontal transcranial direct current stimulation on cognition in schizophrenia: A systematic review and meta-analysis. Schizophrenia Research. PMID 31822431 DOI: 10.1016/J.Schres.2019.11.011  0.331
2019 Wen F, Armstrong N, Hou W, Cruz-Cosme R, Obwolo LA, Ishizuka K, Ullah H, Luo MH, Sawa A, Tang Q. Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1 granules from the centrosome. The Journal of Biological Chemistry. PMID 31666336 DOI: 10.1074/Jbc.Ra119.010973  0.511
2019 Kano SI, Sawa A. Reply to Brune M and Theiss C: Remaining questions in the relationship between T. gondii infection and major mental illness. Molecular Psychiatry. PMID 31641217 DOI: 10.1038/s41380-019-0556-4  0.671
2019 Tomoda T, Yang K, Sawa A. Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders. Biological Psychiatry. PMID 31542152 DOI: 10.1016/j.biopsych.2019.07.018  0.346
2019 Yang K, Kondo MA, Jaaro-Peled H, Cash-Padgett T, Kano SI, Ishizuka K, Pevsner J, Tomoda T, Sawa A, Niwa M. The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood. Schizophrenia Research. PMID 31204062 DOI: 10.1016/J.Schres.2019.05.032  0.826
2019 Fry BR, Russell N, Gifford R, Robles CF, Manning CE, Sawa A, Niwa M, Johnson AW. Assessing Reality Testing in Mice Through Dopamine-Dependent Associatively Evoked Processing of Absent Gustatory Stimuli. Schizophrenia Bulletin. PMID 31150554 DOI: 10.1093/Schbul/Sbz043  0.682
2019 John JP, Thirunavukkarasu P, Ishizuka K, Parekh P, Sawa A. An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration. Npj Systems Biology and Applications. 5: 17. PMID 31098296 DOI: 10.1038/s41540-019-0094-3  0.509
2019 Nucifora LG, MacDonald ML, Lee BJ, Peters ME, Norris AL, Orsburn BC, Yang K, Gleason K, Margolis RL, Pevsner J, Tamminga CA, Sweet RA, Ross CA, Sawa A, Nucifora FC. Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia. The American Journal of Psychiatry. appiajp201918070864. PMID 31055969 DOI: 10.1176/Appi.Ajp.2019.18070864  0.565
2019 Mueller FS, Richetto J, Hayes LN, Zambon A, Pollak DD, Sawa A, Meyer U, Weber-Stadlbauer U. Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation. Brain, Behavior, and Immunity. PMID 30980948 DOI: 10.1016/J.Bbi.2019.04.019  0.541
2019 Tharakan R, Kreimer S, Ubaida-Mohien C, Lavoie J, Olexiouk V, Menschaert G, Ingolia NT, Cole RN, Ishizuka K, Sawa A, Nucifora LG. A methodology for discovering novel brain-relevant peptides: Combination of ribosome profiling and peptidomics. Neuroscience Research. PMID 30862443 DOI: 10.1016/J.Neures.2019.02.006  0.697
2019 Namkung H, Lee BJ, Sawa A. Causal Inference on Pathophysiological Mediators in Psychiatry. Cold Spring Harbor Symposia On Quantitative Biology. PMID 30850434 DOI: 10.1101/Sqb.2018.83.037655  0.691
2019 Hikida T, Morita M, Kuroiwa M, Macpherson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience Research. PMID 30831136 DOI: 10.1016/J.Neures.2019.02.007  0.725
2019 Kano SI, Choi EY, Dohi E, Agarwal S, Chang DJ, Wilson AM, Lo BD, Rose IVL, Gonzalez S, Imai T, Sawa A. Glutathione -transferases promote proinflammatory astrocyte-microglia communication during brain inflammation. Science Signaling. 12. PMID 30783009 DOI: 10.1126/Scisignal.Aar2124  0.777
2019 Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A. The glutathione cycle shapes synaptic glutamate activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 30692251 DOI: 10.1073/Pnas.1817885116  0.58
2019 Wang AM, Pradhan S, Coughlin JM, Trivedi A, DuBois SL, Crawford JL, Sedlak TW, Nucifora FC, Nestadt G, Nucifora LG, Schretlen DJ, Sawa A, Barker PB. Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis. Jama Psychiatry. PMID 30624573 DOI: 10.1001/Jamapsychiatry.2018.3637  0.629
2019 Coughlin J, Du Y, Crawford J, Rubin L, Azad BB, Lesniak WL, Horti A, Schretlen D, Sawa A, Pomper M. 23.4 PET-BASED PRECISION NEUROIMAGING OF THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR IN PATIENTS WITH RECENT ONSET OF PSYCHOSIS Schizophrenia Bulletin. 45: S127-S127. DOI: 10.1093/Schbul/Sbz022.094  0.605
2019 Nucifora L, MacDonald M, Lee B, Peters M, Norris A, Orsburn BO, Gleason K, Yang K, Margolis R, Pevsner J, Tamminga C, Sweet R, Ross C, Sawa A, Nucifora F. O2.3. Increased Protein Insolubility In Brains From A Subset Of Patients With Schizophrenia Schizophrenia Bulletin. 45. DOI: 10.1093/Schbul/Sbz021.187  0.527
2019 Nucifora L, MacDonald M, Lee B, Peters M, Norris A, Orsburn B, Yang K, Gleason K, Margolis R, Pevsner J, Tamminga C, Sweet R, Ross C, Sawa A, Nucifora F. F168. Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.705  0.528
2018 Coughlin J, Du Y, Crawford JL, Rubin LH, Behnam Azad B, Lesniak WG, Horti AG, Schretlen DJ, Sawa A, Pomper MG. The availability of the α7 nicotinic acetylcholine receptor in recent-onset psychosis: a study using F-ASEM PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 30573639 DOI: 10.2967/Jnumed.118.213686  0.622
2018 Nucifora FC, Woznica E, Lee BJ, Cascella N, Sawa A. Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives. Neurobiology of Disease. PMID 30170114 DOI: 10.1016/j.nbd.2018.08.016  0.356
2018 Kano SI, Hodgkinson CA, Jones-Brando L, Eastwood S, Ishizuka K, Niwa M, Choi EY, Chang DJ, Chen Y, Velivela SD, Leister F, Wood J, Chowdari K, Ducci F, Caycedo DA, ... ... Sawa A, et al. Host-parasite interaction associated with major mental illness. Molecular Psychiatry. PMID 30127472 DOI: 10.1038/S41380-018-0217-Z  0.804
2018 Sumitomo A, Horike K, Hirai K, Butcher N, Boot E, Sakurai T, Nucifora FC, Bassett AS, Sawa A, Tomoda T. A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson's disease and schizophrenia. Science Advances. 4: eaar6637. PMID 30116778 DOI: 10.1126/Sciadv.Aar6637  0.329
2018 Cardarelli RA, Martin R, Jaaro-Peled H, Sawa A, Powell EM, O'Donnell P. Dominant-Negative DISC1 Alters the Dopaminergic Modulation of Inhibitory Interneurons in the Mouse Prefrontal Cortex. Molecular Neuropsychiatry. 4: 20-29. PMID 29998115 DOI: 10.1159/000488030  0.742
2018 Namkung H, Kim SH, Sawa A. The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology: (Trends in Neuroscience 40, 200-207, 2017). Trends in Neurosciences. PMID 29895478 DOI: 10.1016/J.Tins.2018.05.004  0.664
2018 Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, ... ... Sawa A, et al. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human Molecular Genetics. PMID 29893844 DOI: 10.1093/Hmg/Ddy219  0.8
2018 Sumitomo A, Saka A, Ueta K, Horike K, Hirai K, Gamo NJ, Hikida T, Nakayama KI, Sawa A, Sakurai T, Tomoda T. Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in -Deficient Mice. Molecular Neuropsychiatry. 3: 223-233. PMID 29888233 DOI: 10.1159/000488081  0.783
2018 Sedlak TW, Nucifora LG, Koga M, Shaffer LS, Higgs C, Tanaka T, Wang AM, Coughlin JM, Barker PB, Fahey JW, Sawa A. Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study. Molecular Neuropsychiatry. 3: 214-222. PMID 29888232 DOI: 10.1159/000487639  0.639
2018 Lockhart S, Sawa A, Niwa M. Developmental trajectories of brain maturation and behavior: Relevance to major mental illnesses. Journal of Pharmacological Sciences. PMID 29773518 DOI: 10.1016/J.Jphs.2018.04.008  0.674
2018 Endo R, Takashima N, Nekooki-Machida Y, Komi Y, Hui KK, Takao M, Akatsu H, Murayama S, Sawa A, Tanaka M. TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration. Biological Psychiatry. PMID 29752072 DOI: 10.1016/j.biopsych.2018.03.008  0.371
2018 McLean CK, Narayan S, Lin SY, Rai N, Chung Y, Hipolito MS, Cascella NG, Nurnberger JI, Ishizuka K, Sawa AS, Nwulia EA. Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder. Translational Psychiatry. 8: 81. PMID 29666369 DOI: 10.1038/S41398-018-0126-6  0.51
2018 Akamine S, Sagata N, Sakai Y, Kato TA, Nakahara T, Matsushita Y, Togao O, Hiwatashi A, Sanefuji M, Ishizaki Y, Torisu H, Saitsu H, Matsumoto N, Hara T, Sawa A, et al. Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations inand. Epilepsia Open. 3: 81-85. PMID 29588991 DOI: 10.1002/epi4.12085  0.695
2018 Wong DF, Kuwabara H, Horti AG, Roberts JM, Nandi A, Casella N, Brasic J, Weerts EM, Kitzmiller K, Phan JA, Gapasin L, Sawa A, Valentine H, Wand G, George N, et al. PET Brain imaging of α7-nAChR with [18F]ASEM: Reproducibility, occupancy, receptor density, and changes in schizophrenia. The International Journal of Neuropsychopharmacology. PMID 29522184 DOI: 10.1093/Ijnp/Pyy021  0.308
2018 Srivastava R, Faust T, Ramos A, Ishizuka K, Sawa A. Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models. Biological Psychiatry. PMID 29486891 DOI: 10.1016/J.Biopsych.2018.01.007  0.806
2018 Posporelis S, Coughlin JM, Marsman A, Pradhan S, Tanaka T, Wang H, Varvaris M, Ward R, Higgs C, Edwards JA, Ford CN, Kim PK, Lloyd AM, Edden RAE, Schretlen DJ, ... ... Sawa A, et al. Decoupling of Brain Temperature and Glutamate in Recent Onset of Schizophrenia: A 7T Proton Magnetic Resonance Spectroscopy Study. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 3: 248-254. PMID 29486866 DOI: 10.1016/J.Bpsc.2017.04.003  0.798
2018 Ooms M, Tsujikawa T, Lohith TG, Mabins SN, Zoghbi SS, Sumitomo A, Jaaro-Peled H, Kimura Y, Telu S, Pike VW, Tomoda T, Innis RB, Sawa A, Fujita M. [C]( R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18758997. PMID 29430995 DOI: 10.1177/0271678X18758997  0.737
2018 Fukudome D, Hayes LN, Faust TE, Foss CA, Kondo MA, Lee BJ, Saito A, Kano SI, Coughlin JM, Kamiya A, Pomper MG, Sawa A, Niwa M. Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances. Schizophrenia Research. PMID 29398205 DOI: 10.1016/J.Schres.2018.01.015  0.791
2018 Coughlin J, Notter T, Du Y, Pomper M, Sawa A, Meyer U. 6.1 STUDY OF ALTERED NEUROIMMUNITY IN PSYCHOSIS USING PET-BASED IMAGING OF THE TRANSLOCATOR PROTEIN 18 KDA: PROMISES, PITFALLS, AND FUTURE DIRECTIONS Schizophrenia Bulletin. 44: S8-S8. DOI: 10.1093/Schbul/Sby014.018  0.619
2018 Coughlin J, Du Y, Greene A, Horti A, Wong D, Sawa A, Pomper M. T246. Low Availability of the α7 Nicotinic Acetylcholine Receptor Distinguishes Recent Onset of Non-Affective Psychosis From Affective Psychosis: A Study Using [18F]ASEM PET Biological Psychiatry. 83: S224-S225. DOI: 10.1016/J.Biopsych.2018.02.583  0.607
2018 Shevelkin A, Terrillion C, Crawford J, Kim S, Fukudome D, Sawa A, Kamiya A, Pletnikov M. T209. Selective DISC1 Knockdown in Astrocytes Produces Region-Dependent Effects on Cognitive Function Biological Psychiatry. 83: S209-S210. DOI: 10.1016/J.Biopsych.2018.02.546  0.497
2018 Kulason S, Schretlen D, Sawa A, Ratnanather T, Ishizuka K. S228. Measuring the Relationship Between Specific Phosphorylation of DISC1 and Cortical Thickness in Psychotic Disorders Biological Psychiatry. 83: S436-S437. DOI: 10.1016/J.Biopsych.2018.02.1120  0.517
2017 Gault JM, Davis R, Cascella NG, Saks ER, Corripio-Collado I, Anderson WS, Olincy A, Thompson JA, Pomarol-Clotet E, Sawa A, Daskalakis ZJ, Lipsman N, Abosch A. Approaches to neuromodulation for schizophrenia. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29242310 DOI: 10.1136/Jnnp-2017-316946  0.348
2017 Park SJ, Lee SB, Suh Y, Kim SJ, Lee N, Hong JH, Park C, Woo Y, Ishizuka K, Kim JH, Berggren PO, Sawa A, Park SK. DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca2+ Transfer through the MAM. Cell Reports. 21: 2748-2759. PMID 29212023 DOI: 10.1016/J.Celrep.2017.11.043  0.722
2017 Notter T, Coughlin JM, Sawa A, Meyer U. Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry. Molecular Psychiatry. 23: 36-47. PMID 29203847 DOI: 10.1038/Mp.2017.232  0.654
2017 Sagata N, Kato TA, Kano SI, Ohgidani M, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Wilson AM, Ishizuka K, Kato S, Nakahara T, Nakahara-Kido M, Setoyama D, Sakai Y, ... ... Sawa A, et al. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study. Scientific Reports. 7: 13905. PMID 29066822 DOI: 10.1038/S41598-017-14440-7  0.792
2017 Kamath V, Lasutschinkow P, Ishizuka K, Sawa A. Olfactory Functioning in First-Episode Psychosis. Schizophrenia Bulletin. PMID 28981913 DOI: 10.1093/Schbul/Sbx107  0.573
2017 Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Molecular Psychiatry. 23: 1717-1730. PMID 28924188 DOI: 10.1038/Mp.2017.177  0.332
2017 Nucifora LG, Tanaka T, Hayes LN, Kim M, Lee BJ, Matsuda T, Nucifora FC, Sedlak T, Mojtabai R, Eaton W, Sawa A. Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry. Translational Psychiatry. 7: e1215. PMID 28892069 DOI: 10.1038/Tp.2017.178  0.623
2017 Nucifora FC, Mihaljevic M, Lee BJ, Sawa A. Clozapine as a Model for Antipsychotic Development. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28653280 DOI: 10.1007/s13311-017-0552-9  0.364
2017 Shao L, Lu B, Wen Z, Teng S, Wang L, Zhao Y, Wang L, Ishizuka K, Xu X, Sawa A, Song H, Ming G, Zhong Y. Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Human Molecular Genetics. PMID 28472294 DOI: 10.1093/Hmg/Ddx147  0.622
2017 Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Henry Hornfeld S, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R. BDNF Overexpression Prevents Cognitive Deficit Elicited by Adolescent Cannabis Exposure and Host Susceptibility Interaction. Human Molecular Genetics. PMID 28402427 DOI: 10.1093/Hmg/Ddx139  0.755
2017 Lavoie J, Sawa A, Ishizuka K. Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research. Current Opinion in Psychiatry. PMID 28333692 DOI: 10.1097/Yco.0000000000000327  0.737
2017 Namkung H, Kim SH, Sawa A. The Insula: An Underestimated Brain Area in Clinical Neuroscience, Psychiatry, and Neurology. Trends in Neurosciences. PMID 28314446 DOI: 10.1016/J.Tins.2017.02.002  0.686
2017 Tanaka M, Ishizuka K, Nekooki-Machida Y, Endo R, Takashima N, Sasaki H, Komi Y, Gathercole A, Huston E, Ishii K, Hui KK, Kurosawa M, Kim SH, Nukina N, Takimoto E, ... ... Sawa A, et al. Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease. The Journal of Clinical Investigation. PMID 28263187 DOI: 10.1172/Jci85594  0.567
2017 Lavoie J, Gassó Astorga P, Segal-Gavish H, Wu YC, Chung Y, Cascella NG, Sawa A, Ishizuka K. The Olfactory Neural Epithelium As a Tool in Neuroscience. Trends in Molecular Medicine. PMID 28108112 DOI: 10.1016/J.Molmed.2016.12.010  0.772
2017 Notter T, Coughlin JM, Gschwind T, Weber-Stadlbauer U, Wang Y, Kassiou M, Vernon AC, Benke D, Pomper MG, Sawa A, Meyer U. Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia. Molecular Psychiatry. PMID 28093569 DOI: 10.1038/Mp.2016.248  0.701
2017 Sedlak T, Koga M, Shaffer L, Fahey J, Snyder S, Barker P, Sawa A. 175.2 A Glu That Binds Inflammation and Neurotransmission: Glutathione as a Glutamate Reservoir Schizophrenia Bulletin. 43: S89-S89. DOI: 10.1093/schbul/sbx021.239  0.378
2017 Niwa M, Sawa A. 118.3 Glucocorticoid-Mediated Epigenetic Control of Dopaminergic Neurons in a Trajectory From Adolescent Stress to Adult Behavior Schizophrenia Bulletin. 43: S66-S66. DOI: 10.1093/Schbul/Sbx021.175  0.655
2017 Notter T, Coughlin J, Gschwind T, Weber-Stadlbauer U, Wang Y, Kassiou M, Vernon A, Benke D, Pomper M, Sawa A, Meyer U. 117.2 Translational Evaluation of Translocator Protein (TSPO) as a Marker of Neuroinflammation in Schizophrenia Schizophrenia Bulletin. 43: S64-S64. DOI: 10.1093/Schbul/Sbx021.169  0.672
2017 Tomoda T, Dzirasa K, Saudou F, Sawa A, Jaaro-Peled H. 439. Role for DISC1 in Sensorimotor Gating: Its Impact on Corticostriatal Transport of BDNF Biological Psychiatry. 81: S179-S180. DOI: 10.1016/J.Biopsych.2017.02.923  0.667
2017 Ishizuka K, Tanaka M, Houslay M, Sawa A. 438. Amyloidogenic DISC1: Role for Psychiatric Manifestation in Neurodegenerative Disorders Biological Psychiatry. 81: S179. DOI: 10.1016/J.Biopsych.2017.02.922  0.534
2016 Lee BJ, Marchionni L, Andrews CE, Norris AL, Nucifora LG, Wu YC, Wright RA, Pevsner J, Ross CA, Margolis RL, Sawa A, Nucifora FC. Analysis of differential gene expression mediated by clozapine in human postmortem brains. Schizophrenia Research. PMID 28038920 DOI: 10.1016/J.Schres.2016.12.017  0.54
2016 Sumitomo A, Ueta K, Mauchi S, Hirai K, Horike K, Hikida T, Sakurai T, Sawa A, Tomoda T. Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits. Neuroscience Research. PMID 28017600 DOI: 10.1016/J.Neures.2016.12.004  0.548
2016 Coughlin JM, Wang Y, Minn I, Bienko N, Ambinder EB, Xu X, Peters ME, Dougherty JW, Vranesic M, Koo SM, Ahn HH, Lee M, Cottrell C, Sair HI, Sawa A, et al. Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players. Jama Neurology. PMID 27893897 DOI: 10.1001/Jamaneurol.2016.3764  0.627
2016 Coughlin JM, Hayes LN, Tanaka T, Xiao M, Yolken RH, Worley P, Leweke FM, Sawa A. Reduced superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with early psychosis in association with clinical features. Schizophrenia Research. PMID 27889384 DOI: 10.1016/J.Schres.2016.10.040  0.779
2016 Gamo NJ, Birknow MR, Sullivan D, Kondo MA, Horiuchi Y, Sakurai T, Slusher BS, Sawa A. Valley of death: A proposal to build a "translational bridge" for the next generation. Neuroscience Research. PMID 27876581 DOI: 10.1016/J.Neures.2016.11.003  0.744
2016 Nucifora LG, Wu YC, Lee BJ, Sha L, Margolis RL, Ross CA, Sawa A, Nucifora FC. A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation. Molecular Neuropsychiatry. 2: 133-144. PMID 27867938 DOI: 10.1159/000447358  0.471
2016 Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T. Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning. Molecular Neuropsychiatry. 2: 124-132. PMID 27867937 DOI: 10.1159/000447970  0.698
2016 Tanaka T, Matsuda T, Hayes LN, Yang S, Rodriguez K, Severance EG, Yolken RH, Sawa A, Eaton W. Infection and inflammation in schizophrenia and bipolar disorder. Neuroscience Research. PMID 27856235 DOI: 10.1016/j.neures.2016.11.002  0.587
2016 Delevich K, Abi-Dargham A, Hall J, Sawa A. Studying schizophrenia in the post-genomic era: perspectives from the 2016 summer Banbury Workshop at Cold Spring Harbor Laboratory. Molecular Psychiatry. PMID 27777417 DOI: 10.1038/Mp.2016.197  0.373
2016 Horiuchi Y, Kondo MA, Okada K, Takayanagi Y, Tanaka T, Ho T, Varvaris M, Tajinda K, Hiyama H, Ni K, Colantuoni C, Schretlen D, Cascella NG, Pevsner J, Ishizuka K, ... Sawa A, et al. Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium. Translational Psychiatry. 6: e915. PMID 27727244 DOI: 10.1038/Tp.2016.154  0.592
2016 Hayes LN, Shevelkin A, Zeledon M, Steel G, Chen PL, Obie C, Pulver A, Avramopoulos D, Valle D, Sawa A, Pletnikov MV. Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders. Molecular Neuropsychiatry. 2: 79-87. PMID 27606322 DOI: 10.1159/000445836  0.825
2016 Xia M, Broek JA, Jouroukhin Y, Schoenfelder J, Abazyan S, Jaaro-Peled H, Sawa A, Bahn S, Pletnikov M. Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study. Molecular Neuropsychiatry. 2: 28-36. PMID 27606318 DOI: 10.1159/000444587  0.732
2016 Furukubo-Tokunaga K, Kurita K, Honjo K, Pandey H, Ando T, Takayama K, Arai Y, Mochizuki H, Ando M, Kamiya A, Sawa A. Visualization of DISC1-Dysbindin interaction in glutamatergic synaptic termini in fruit flies. Molecular Psychiatry. 21: 1157. PMID 27545194 DOI: 10.1038/Mp.2016.142  0.488
2016 Tankou S, Ishii K, Elliott C, Yalla KC, Day JP, Furukori K, Kubo KI, Brandon NJ, Tang Q, Hayward G, Nakajima K, Houslay MD, Kamiya A, Baillie G, Ishizuka K, ... Sawa A, et al. SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Molecular Neuropsychiatry. 2: 20-27. PMID 27525255 DOI: 10.1159/000444257  0.806
2016 Wang Y, Coughlin JM, Ma S, Endres CJ, Kassiou M, Sawa A, Dannals RF, Petri M, Pomper MG. Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography. Lupus. PMID 27387599 DOI: 10.1177/0961203316657432  0.642
2016 Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, ... Sawa A, et al. Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation. Cerebral Cortex (New York, N.Y. : 1991). PMID 27371763 DOI: 10.1093/Cercor/Bhw201  0.625
2016 Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A. Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1. Neuroscience Research. PMID 27354230 DOI: 10.1016/J.Neures.2016.06.006  0.778
2016 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, ... ... Sawa A, et al. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry. 80: 84-6. PMID 27346079 DOI: 10.1016/J.Biopsych.2016.05.004  0.512
2016 Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T. Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learning & Memory (Cold Spring Harbor, N.Y.). 23: 359-64. PMID 27317196 DOI: 10.1101/Lm.042507.116  0.524
2016 Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nature Communications. 7: 11792. PMID 27273569 DOI: 10.1038/Ncomms11792  0.572
2016 Kim SH, Shahani N, Bae BI, Sbodio JI, Chung Y, Nakaso K, Paul BD, Sawa A. Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53. Human Molecular Genetics. PMID 27206983 DOI: 10.1093/Hmg/Ddw115  0.787
2016 Coughlin JM, Wang Y, Ambinder EB, Ward RE, Minn I, Vranesic M, Kim PK, Ford CN, Higgs C, Hayes LN, Schretlen DJ, Dannals RF, Kassiou M, Sawa A, Pomper MG. In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma. Translational Psychiatry. 6: e777. PMID 27070405 DOI: 10.1038/Tp.2016.40  0.755
2016 Furukubo-Tokunaga K, Kurita K, Honjo K, Pandey H, Ando T, Takayama K, Arai Y, Mochizuki H, Ando M, Kamiya A, Sawa A. DISC1 causes associative memory and neurodevelopmental defects in fruit flies. Molecular Psychiatry. PMID 26976042 DOI: 10.1038/Mp.2016.15  0.549
2016 Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, ... ... Sawa A, et al. Altering the course of schizophrenia: progress and perspectives. Nature Reviews. Drug Discovery. PMID 26939910 DOI: 10.1038/Nrd.2016.28  0.397
2016 Niwa M, Lee RS, Tanaka T, Okada K, Kano SI, Sawa A. A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons. Human Molecular Genetics. PMID 26908623 DOI: 10.1093/Hmg/Ddw019  0.8
2016 Kondo MA, Fukudome D, Smith DR, Gallagher M, Kamiya A, Sawa A. Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis. Neuroscience Research. PMID 26869217 DOI: 10.1016/J.Neures.2016.01.006  0.534
2016 Sawa A, Ishizuka K, Katsanis N. The potential of DISC1 protein as a therapeutic target for mental illness. Expert Opinion On Therapeutic Targets. PMID 26810812 DOI: 10.1517/14728222.2016.1146694  0.51
2016 Tomoda T, Sumitomo A, Jaaro-Peled H, Sawa A. Utility and validity of DISC1 mouse models in biological psychiatry. Neuroscience. PMID 26768401 DOI: 10.1016/J.Neuroscience.2015.12.061  0.75
2016 Niwa M, Cash-Padgett T, Kubo KI, Saito A, Ishii K, Sumitomo A, Taniguchi Y, Ishizuka K, Jaaro-Peled H, Tomoda T, Nakajima K, Sawa A, Kamiya A. DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1 Molecular Psychiatry. DOI: 10.1038/Mp.2016.154  0.808
2015 Seshadri S, Faust T, Ishizuka K, Delevich K, Chung Y, Kim SH, Cowles M, Niwa M, Jaaro-Peled H, Tomoda T, Lai C, Anton ES, Li B, Sawa A. Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. Nature Communications. 6: 10118. PMID 26656849 DOI: 10.1038/Ncomms10118  0.81
2015 Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, ... Sawa A, et al. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. PMID 26610635 DOI: 10.1016/J.Stemcr.2015.10.011  0.319
2015 Zeledón M, Eckart N, Taub M, Vernon H, Szymanksi M, Wang R, Chen PL, Nestadt G, McGrath JA, Sawa A, Pulver AE, Avramopoulos D, Valle D. Identification and functional studies of regulatory variants responsible for the association of NRG3 with a delusion phenotype in schizophrenia. Molecular Neuropsychiatry. 1: 36-46. PMID 26528484 DOI: 10.1159/000371518  0.8
2015 Hayashi Y, Sawa A, Hikida T. Impaired hippocampal activity at the goal zone on the place preference task in a DISC1 mouse model. Neuroscience Research. PMID 26497623 DOI: 10.1016/J.Neures.2015.10.005  0.567
2015 Cash-Padgett T, Sawa A, Jaaro-Peled H. Increased stereotypy in conditional Cxcr4 knockout mice. Neuroscience Research. PMID 26458529 DOI: 10.1016/J.Neures.2015.10.001  0.735
2015 Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, Sakurai T. Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex. Molecular Neuropsychiatry. 1: 94-104. PMID 26457295 DOI: 10.1159/000430095  0.67
2015 Passeri E, Jones-Brando L, Bordón C, Sengupta S, Wilson AM, Primerano A, Rapoport JL, Ishikuza K, Kano SI, Yolken RH, Sawa A. Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls. Microbes and Infection / Institut Pasteur. PMID 26432947 DOI: 10.1016/J.Micinf.2015.09.023  0.809
2015 Altimus C, Harrold J, Jaaro-Peled H, Sawa A, Foster DJ. Disordered ripples are a common feature of genetically distinct mouse models relevant to schizophrenia. Molecular Neuropsychiatry. 1: 52-59. PMID 26417572 DOI: 10.1159/000380765  0.724
2015 Sakurai T, Gamo NJ, Hikida T, Kim SH, Murai T, Tomoda T, Sawa A. Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments. Progress in Neurobiology. PMID 26408506 DOI: 10.1016/J.Pneurobio.2015.09.010  0.806
2015 Landek-Salgado MA, Faust TE, Sawa A. Molecular substrates of schizophrenia: homeostatic signaling to connectivity. Molecular Psychiatry. PMID 26390828 DOI: 10.1038/Mp.2015.141  0.658
2015 Passeri E, Wilson AM, Primerano A, Kondo MA, Sengupta S, Srivastava R, Koga M, Obie C, Zandi PP, Goes FS, Valle D, Rapoport JL, Sawa A, Kano SI, Ishizuka K. Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. Neuroscience Research. PMID 26260244 DOI: 10.1016/J.Neures.2015.07.011  0.792
2015 Posporelis S, Paspali A, Takayanagi Y, Sawa A, Banerjea P, Kyriakopoulos M. Demographic and clinical correlates of suicidality in adolescents attending a specialist community mental health service: a naturalistic study. Journal of Mental Health (Abingdon, England). 1-5. PMID 26203534 DOI: 10.3109/09638237.2015.1022249  0.765
2015 Rais R, Wozniak K, Wu Y, Niwa M, Stathis M, Alt J, Giroux M, Sawa A, Rojas C, Slusher BS. Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration. Plos One. 10: e0131861. PMID 26151906 DOI: 10.1371/Journal.Pone.0131861  0.656
2015 Ballinger MD, Saito A, Abazyan B, Taniguchi Y, Huang CH, Ito K, Zhu X, Segal H, Jaaro-Peled H, Sawa A, Mackie K, Pletnikov MV, Kamiya A. Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory. Neurobiology of Disease. PMID 26093170 DOI: 10.1016/J.Nbd.2015.06.006  0.761
2015 Nomura J, Jaaro-Peled H, Lewis E, Nuñez-Abades P, Huppe-Gourgues F, Cash-Padgett T, Emiliani F, Kondo MA, Furuya A, Landek-Salgado MA, Ayhan Y, Kamiya A, Takumi T, Huganir R, Pletnikov M, ... ... Sawa A, et al. Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Molecular Psychiatry. PMID 26008737 DOI: 10.1038/Mp.2015.61  0.79
2015 Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. The Journal of Biological Chemistry. 290: 14493-503. PMID 25882840 DOI: 10.1074/Jbc.M114.635607  0.785
2015 Barodia SK, Park SK, Ishizuka K, Sawa A, Kamiya A. Half-life of DISC1 protein and its pathological significance under hypoxia stress. Neuroscience Research. 97: 1-6. PMID 25738396 DOI: 10.1016/J.Neures.2015.02.008  0.672
2015 Coughlin JM, Tanaka T, Marsman A, Wang H, Bonekamp S, Kim PK, Higgs C, Varvaris M, Edden RA, Pomper M, Schretlen D, Barker PB, Sawa A. Decoupling of N-acetyl-aspartate and glutamate within the dorsolateral prefrontal cortex in schizophrenia. Current Molecular Medicine. 15: 176-83. PMID 25732147 DOI: 10.2174/1566524015666150303104811  0.762
2015 Kano S, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, ... ... Sawa A, et al. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. Current Molecular Medicine. 15: 138-45. PMID 25732146 DOI: 10.2174/1566524015666150303110300  0.792
2015 Zoubovsky S, Oh EC, Cash-Padgett T, Johnson AW, Hou Z, Mori S, Gallagher M, Katsanis N, Sawa A, Jaaro-Peled H. Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Neuroscience Research. PMID 25697395 DOI: 10.1016/J.Neures.2015.02.002  0.722
2015 Coughlin JM, Wang Y, Munro CA, Ma S, Yue C, Chen S, Airan R, Kim PK, Adams AV, Garcia C, Higgs C, Sair HI, Sawa A, Smith G, Lyketsos CG, et al. Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study. Neurobiology of Disease. 74: 58-65. PMID 25447235 DOI: 10.1016/J.Nbd.2014.10.019  0.65
2015 Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A. Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade. The Journal of Biological Chemistry. 290: 56-64. PMID 25391652 DOI: 10.1074/Jbc.M114.596205  0.773
2015 Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. DISC1 regulates trafficking and processing of APP and Aβ generation. Molecular Psychiatry. 20: 874-9. PMID 25224257 DOI: 10.1038/Mp.2014.100  0.8
2015 Zhang M, Sasaki H, Saitoh T, Koitabashi N, Zhu G, Tsujimura T, Lee D, Tristan C, Shahani N, Kariya T, Tsuchiya Y, Jaaro-Peled H, Slusher B, Kass D, Taguchi K, ... ... Sawa A, et al. NUCLEAR GLYCELALDEHYDE-3-PHOSPHATE DEHYDROGENASE SIGNALING MEDIATES PATHOLOGICAL CARDIAC HYPERTROPHY VIA P300 AND MYOCYTE ENHANCER FACTOR 2 Journal of the American College of Cardiology. 65: A2153. DOI: 10.1016/S0735-1097(15)62153-2  0.778
2014 Narayan S, McLean C, Sawa A, Lin SY, Rai N, Hipolito MS, Cascella N, Nurnberger JJ, Ishizuka K, Nwulia EA. Olfactory neurons obtained through nasal biopsy combined with laser-capture microdissection: a potential approach to study treatment response in mental disorders. Journal of Visualized Experiments : Jove. PMID 25549156 DOI: 10.3791/51853  0.565
2014 Takayanagi Y, Petersen L, Laursen TM, Cascella NG, Sawa A, Mortensen PB, Eaton WW. Risk of schizophrenia spectrum and affective disorders associated with small for gestational age birth and height in adulthood. Schizophrenia Research. 160: 230-2. PMID 25458575 DOI: 10.1016/j.schres.2014.10.018  0.342
2014 Lee RS, Sawa A. Environmental stressors and epigenetic control of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology. 100: 278-87. PMID 25427939 DOI: 10.1159/000369585  0.334
2014 Sawa A, Seidman LJ. Is prophylactic psychiatry around the corner? combating adolescent oxidative stress for adult psychosis and schizophrenia. Neuron. 83: 991-3. PMID 25189204 DOI: 10.1016/J.Neuron.2014.08.028  0.35
2014 Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, et al. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Human Molecular Genetics. 23: 5859-65. PMID 24934694 DOI: 10.1093/Hmg/Ddu303  0.722
2014 Gamo NJ, Sawa A. Human stem cells and surrogate tissues for basic and translational study of mental disorders. Biological Psychiatry. 75: 918-9. PMID 24862565 DOI: 10.1016/j.biopsych.2014.03.025  0.776
2014 Hayes LN, Severance EG, Leek JT, Gressitt KL, Rohleder C, Coughlin JM, Leweke FM, Yolken RH, Sawa A. Inflammatory molecular signature associated with infectious agents in psychosis. Schizophrenia Bulletin. 40: 963-72. PMID 24743863 DOI: 10.1093/Schbul/Sbu052  0.729
2014 Hayashi-Takagi A, Araki Y, Nakamura M, Vollrath B, Duron SG, Yan Z, Kasai H, Huganir RL, Campbell DA, Sawa A. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proceedings of the National Academy of Sciences of the United States of America. 111: 6461-6. PMID 24706880 DOI: 10.1073/Pnas.1321109111  0.743
2014 Coughlin JM, Wang Y, Ma S, Yue C, Kim PK, Adams AV, Roosa HV, Gage KL, Stathis M, Rais R, Rojas C, McGlothan JL, Watkins CC, Sacktor N, Guilarte TR, ... ... Sawa A, et al. Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV. Journal of Neurovirology. 20: 219-32. PMID 24567030 DOI: 10.1007/S13365-014-0239-5  0.754
2014 Posporelis S, Sawa A, Smith GS, Stitzer ML, Lyketsos CG, Chisolm MS. Promoting careers in academic research to psychiatry residents. Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association For Academic Psychiatry. 38: 185-90. PMID 24497181 DOI: 10.1007/S40596-014-0037-7  0.757
2014 Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, et al. DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Molecular Psychiatry. 19: 141-3. PMID 24457522 DOI: 10.1038/Mp.2013.160  0.576
2014 Watkins CC, Sawa A, Pomper MG. Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. Translational Psychiatry. 4: e350. PMID 24448212 DOI: 10.1038/Tp.2013.119  0.678
2014 Brennand KJ, Landek-Salgado MA, Sawa A. Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells. Biological Psychiatry. 75: 936-44. PMID 24331955 DOI: 10.1016/J.Biopsych.2013.10.025  0.364
2014 Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z. Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1. Biological Psychiatry. 75: 414-24. PMID 23906531 DOI: 10.1016/J.Biopsych.2013.06.009  0.801
2014 Nucifora F, Nucifora L, Arbez N, Roby E, Yu L, Wei D, DeLisi L, Sawa A, Ross C, Margolis R. Poster #T175 NPAS3: NEW GENETIC AND BIOLOGICAL FINDINGS WITH IMPLICATIONS FOR PROTEIN AGGREGATION AND SCHIZOPHRENIA Schizophrenia Research. 153: S351. DOI: 10.1016/S0920-9964(14)70991-0  0.52
2014 Posporelis S, Varvaris M, Marsman A, Coughlin JM, Bonekamp S, Kim P, Edden R, Schretlen DJ, Cascella N, Barker PB, Sawa A. Poster #S49 AN INITIAL REPORT ON METABOLIC DEFECTS IN RECENT ONSET SCHIZOPHRENIA WITH A 7 TESLA MRI SCANNER: LINK TO CHANGES IN BRAIN TEMPERATURE AND COGNITION Schizophrenia Research. 153: S106. DOI: 10.1016/S0920-9964(14)70328-7  0.801
2014 Sawa A, Horiuchi Y, Cascella N, Schretlen D, Ishizuka K. ELUCIDATING THE MOLECULAR PATHOPHYSIOLOGY OF MENTAL ILLNESS WITH OLFACTORY NEURONAL CELLS AND INDUCED PLURIPOTENT STEM CELLS Schizophrenia Research. 153: S45. DOI: 10.1016/S0920-9964(14)70146-X  0.543
2014 Sawa A, Niwa M, Lee R. ADOLESCENT STRESS-INDUCED EPIGENETIC CONTROL OF NEURONAL NETWORKS Schizophrenia Research. 153: S3. DOI: 10.1016/S0920-9964(14)70009-X  0.652
2014 Patil SA, Kano S, Sawa A, Maegawa GH. Using small molecules to increase the direct conversion of culture fibroblasts from MPS II patients into induced-neuronal (iN) cells Molecular Genetics and Metabolism. 111: S84-S85. DOI: 10.1016/J.Ymgme.2013.12.202  0.689
2013 Takayanagi Y, Gerner G, Takayanagi M, Rao V, Vannorsdall TD, Sawa A, Schretlen DJ, Cascella NG. Hippocampal volume reduction correlates with apathy in traumatic brain injury, but not schizophrenia. The Journal of Neuropsychiatry and Clinical Neurosciences. 25: 292-301. PMID 24247856 DOI: 10.1176/Appi.Neuropsych.12040093  0.328
2013 Horiuchi Y, Kano S, Ishizuka K, Cascella NG, Ishii S, Talbot CC, Jaffe AE, Okano H, Pevsner J, Colantuoni C, Sawa A. Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Neuroscience Research. 77: 247-50. PMID 24120685 DOI: 10.1016/J.Neures.2013.09.010  0.761
2013 Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. Proceedings of the National Academy of Sciences of the United States of America. 110: 17552-7. PMID 24101523 DOI: 10.1073/Pnas.1312661110  0.42
2013 Takayanagi M, Wentz J, Takayanagi Y, Schretlen DJ, Ceyhan E, Wang L, Suzuki M, Sawa A, Barta PE, Ratnanather JT, Cascella NG. Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia. Schizophrenia Research. 150: 484-90. PMID 24035178 DOI: 10.1016/J.Schres.2013.07.036  0.35
2013 Tezuka T, Tamura M, Kondo MA, Sakaue M, Okada K, Takemoto K, Fukunari A, Miwa K, Ohzeki H, Kano S, Yasumatsu H, Sawa A, Kajii Y. Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis. Neurobiology of Disease. 59: 63-8. PMID 23867234 DOI: 10.1016/j.nbd.2013.07.003  0.711
2013 Johnson AW, Jaaro-Peled H, Shahani N, Sedlak TW, Zoubovsky S, Burruss D, Emiliani F, Sawa A, Gallagher M. Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proceedings of the National Academy of Sciences of the United States of America. 110: 12462-7. PMID 23840059 DOI: 10.1073/Pnas.1307925110  0.809
2013 Kannan G, Sawa A, Pletnikov MV. Mouse models of gene-environment interactions in schizophrenia. Neurobiology of Disease. 57: 5-11. PMID 23748077 DOI: 10.1016/j.nbd.2013.05.012  0.421
2013 Soda T, Frank C, Ishizuka K, Baccarella A, Park YU, Flood Z, Park SK, Sawa A, Tsai LH. DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Molecular Psychiatry. 18: 898-908. PMID 23587879 DOI: 10.1038/mp.2013.38  0.553
2013 Kondo MA, Tajinda K, Colantuoni C, Hiyama H, Seshadri S, Huang B, Pou S, Furukori K, Hookway C, Jaaro-Peled H, Kano SI, Matsuoka N, Harada K, Ni K, Pevsner J, ... Sawa A, et al. Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control. Translational Psychiatry. 3: e243. PMID 23549417 DOI: 10.1038/Tp.2013.19  0.806
2013 Mor E, Kano S, Colantuoni C, Sawa A, Navon R, Shomron N. MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. Neurobiology of Disease. 55: 1-10. PMID 23542694 DOI: 10.1016/J.Nbd.2013.03.011  0.748
2013 Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, et al. Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia. 61: 679-93. PMID 23382131 DOI: 10.1002/Glia.22461  0.723
2013 Seshadri S, Zeledon M, Sawa A. Synapse-specific contributions in the cortical pathology of schizophrenia. Neurobiology of Disease. 53: 26-35. PMID 23336981 DOI: 10.1016/J.Nbd.2013.01.009  0.808
2013 Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (New York, N.Y.). 339: 335-9. PMID 23329051 DOI: 10.1126/Science.1226931  0.796
2013 Jaaro-Peled H, Niwa M, Foss CA, Murai R, de Los Reyes S, Kamiya A, Mateo Y, O'Donnell P, Cascella NG, Nabeshima T, Guilarte TR, Pomper MG, Sawa A. Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. Human Molecular Genetics. 22: 1574-80. PMID 23314019 DOI: 10.1093/Hmg/Ddt007  0.796
2013 Kano S, Colantuoni C, Han F, Zhou Z, Yuan Q, Wilson A, Takayanagi Y, Lee Y, Rapoport J, Eaton W, Cascella N, Ji H, Goldman D, Sawa A. Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Molecular Psychiatry. 18: 740-2. PMID 22925834 DOI: 10.1038/Mp.2012.120  0.795
2013 Ma TM, Abazyan S, Abazyan B, Nomura J, Yang C, Seshadri S, Sawa A, Snyder SH, Pletnikov MV. Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Molecular Psychiatry. 18: 557-67. PMID 22801410 DOI: 10.1038/mp.2012.97  0.705
2013 Coughlin JM, Ishizuka K, Kano SI, Edwards JA, Seifuddin FT, Shimano MA, Daley EL, Zandi PP, Leweke FM, Cascella NG, Pomper MG, Yolken RH, Sawa A. Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Molecular Psychiatry. 18: 10-1. PMID 22349781 DOI: 10.1038/Mp.2012.6  0.824
2012 Hikida T, Gamo NJ, Sawa A. DISC1 as a therapeutic target for mental illnesses. Expert Opinion On Therapeutic Targets. 16: 1151-60. PMID 23130881 DOI: 10.1517/14728222.2012.719879  0.824
2012 Rais R, Thomas AG, Wozniak K, Wu Y, Jaaro-Peled H, Sawa A, Strick CA, Engle SJ, Brandon NJ, Rojas C, Slusher BS, Tsukamoto T. Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2067-73. PMID 22837388 DOI: 10.1124/Dmd.112.046482  0.682
2012 Bader V, Tomppo L, Trossbach SV, Bradshaw NJ, Prikulis I, Leliveld SR, Lin CY, Ishizuka K, Sawa A, Ramos A, Rosa I, García Á, Requena JR, Hipolito M, Rai N, et al. Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Human Molecular Genetics. 21: 4406-18. PMID 22798627 DOI: 10.1093/Hmg/Dds273  0.826
2012 Golzio C, Willer J, Talkowski ME, Oh EC, Taniguchi Y, Jacquemont S, Reymond A, Sun M, Sawa A, Gusella JF, Kamiya A, Beckmann JS, Katsanis N. KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature. 485: 363-7. PMID 22596160 DOI: 10.1038/Nature11091  0.557
2012 Yang X, Ewald ER, Huo Y, Tamashiro KL, Salvatori R, Sawa A, Wand GS, Lee RS. Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochemical and Biophysical Research Communications. 420: 570-5. PMID 22445894 DOI: 10.1016/J.Bbrc.2012.03.035  0.312
2012 Lin CY, Sawa A, Jaaro-Peled H. Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models. Neurobiology of Disease. 45: 48-56. PMID 21914480 DOI: 10.1016/J.Nbd.2011.08.025  0.829
2012 Shahani N, Sawa A. Protein S-nitrosylation: role for nitric oxide signaling in neuronal death. Biochimica Et Biophysica Acta. 1820: 736-42. PMID 21803124 DOI: 10.1016/J.Bbagen.2011.07.010  0.707
2012 Mouri A, Koseki T, Narusawa S, Niwa M, Mamiya T, Kano S, Sawa A, Nabeshima T. Mouse strain differences in phencyclidine-induced behavioural changes. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 767-79. PMID 21733237 DOI: 10.1017/S146114571100085X  0.793
2012 Taniguchi Y, Young-Pearse T, Sawa A, Kamiya A. In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 18: 169-79. PMID 21551077 DOI: 10.1177/1073858411399925  0.577
2012 Cardarelli RA, Sawa A, O'Donnell P. Poster #80 DISRUPTION OF PREFRONTAL FAST-SPIKING INTERNEURONS IN THE DISC1-DN MOUSE MODEL OF SCHIZOPHRENIA Schizophrenia Research. 136: S120. DOI: 10.1016/S0920-9964(12)70395-X  0.564
2012 Abazvan B, Ma TM, Nomura J, Abazyan S, Sawa A, Snyder SH, Pletnikov MV. Poster #5 DISC1 AND SERINE RACEMASE INTERACT IN ASTROCYTES TO REGULATE D-SERINE PRODUCTION Schizophrenia Research. 136. DOI: 10.1016/S0920-9964(12)70321-3  0.376
2012 Pletnikov MV, Ma TM, Nomura J, Abazyan B, Abazyan S, Sawa A, Snyder SH. DISC1 INTERACTS WITH SERINE RACEMASE TO MODULATE D-SERINE PRODUCTION IN ASTROCYTES Schizophrenia Research. 136: S62. DOI: 10.1016/S0920-9964(12)70234-7  0.368
2011 Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nature Reviews. Neuroscience. 12: 707-22. PMID 22095064 DOI: 10.1038/nrn3120  0.344
2011 Mitchell KJ, Huang ZJ, Moghaddam B, Sawa A. Following the genes: a framework for animal modeling of psychiatric disorders. Bmc Biology. 9: 76. PMID 22078115 DOI: 10.1186/1741-7007-9-76  0.315
2011 Porteous DJ, Millar JK, Brandon NJ, Sawa A. DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends in Molecular Medicine. 17: 699-706. PMID 22015021 DOI: 10.1016/j.molmed.2011.09.002  0.363
2011 Kano S, Nwulia E, Niwa M, Chen Y, Sawa A, Cascella N. Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. Neuroscience Research. 71: 289-93. PMID 21801761 DOI: 10.1016/J.Neures.2011.07.1818  0.792
2011 Flores R, Hirota Y, Armstrong B, Sawa A, Tomoda T. DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway. Neuroscience Research. 71: 71-7. PMID 21664390 DOI: 10.1016/j.neures.2011.05.014  0.377
2011 Hayashi-Takagi A, Barker PB, Sawa A. Readdressing synaptic pruning theory for schizophrenia: Combination of brain imaging and cell biology. Communicative & Integrative Biology. 4: 211-2. PMID 21655443 DOI: 10.4161/cib.4.2.14492  0.75
2011 Koga M, Serritella AV, Messmer MM, Hayashi-Takagi A, Hester LD, Snyder SH, Sawa A, Sedlak TW. Glutathione is a physiologic reservoir of neuronal glutamate. Biochemical and Biophysical Research Communications. 409: 596-602. PMID 21539809 DOI: 10.1016/j.bbrc.2011.04.087  0.73
2011 Zoubovsky SP, Pogorelov VM, Taniguchi Y, Kim SH, Yoon P, Nwulia E, Sawa A, Pletnikov MV, Kamiya A. Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function. Biochemical and Biophysical Research Communications. 408: 707-12. PMID 21539806 DOI: 10.1016/J.Bbrc.2011.04.097  0.613
2011 Ishizuka K, Kamiya A, Oh EC, Kanki H, Seshadri S, Robinson JF, Murdoch H, Dunlop AJ, Kubo K, Furukori K, Huang B, Zeledon M, Hayashi-Takagi A, Okano H, Nakajima K, ... ... Sawa A, et al. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. 473: 92-6. PMID 21471969 DOI: 10.1038/Nature09859  0.797
2011 Ramsey AJ, Milenkovic M, Oliveira AF, Escobedo-Lozoya Y, Seshadri S, Salahpour A, Sawa A, Yasuda R, Caron MG. Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 108: 5795-800. PMID 21436042 DOI: 10.1073/Pnas.1012621108  0.475
2011 Ozeki Y, Pickard BS, Kano S, Malloy MP, Zeledon M, Sun DQ, Fujii K, Wakui K, Shirayama Y, Fukushima Y, Kunugi H, Hashimoto K, Muir WJ, Blackwood DH, Sawa A. A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression. Neuroscience Research. 69: 154-60. PMID 20955740 DOI: 10.1016/J.Neures.2010.10.003  0.803
2011 Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, ... ... Sawa A, et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry. 16: 1006-23. PMID 20838393 DOI: 10.1038/Mp.2010.87  0.798
2011 Shahani N, Sawa A. Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation. Antioxidants & Redox Signaling. 14: 1493-504. PMID 20812870 DOI: 10.1089/Ars.2010.3580  0.707
2011 Tristan C, Shahani N, Sedlak TW, Sawa A. The diverse functions of GAPDH: views from different subcellular compartments. Cellular Signalling. 23: 317-23. PMID 20727968 DOI: 10.1016/J.Cellsig.2010.08.003  0.794
2011 Ayhan Y, Abazyan B, Nomura J, Kim R, Ladenheim B, Krasnova IN, Sawa A, Margolis RL, Cadet JL, Mori S, Vogel MW, Ross CA, Pletnikov MV. Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Molecular Psychiatry. 16: 293-306. PMID 20048751 DOI: 10.1038/Mp.2009.144  0.572
2011 Niwa M, Sawa A. How the brain senses environmental factors and is affected? Neuroscience Research. 71: e13. DOI: 10.1016/J.Neures.2011.07.049  0.652
2011 Ayhan Y, Jaaro-Peled H, Sawa A, Pletnikov MV. DISC1 mouse models Neuromethods. 59: 211-229. DOI: 10.1007/978-1-61779-157-4_9  0.652
2010 Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F, Pogorelov V, Ladenheim B, Yang C, Krasnova IN, Cadet JL, Pardo C, Mori S, Kamiya A, Vogel MW, ... Sawa A, et al. Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biological Psychiatry. 68: 1172-81. PMID 21130225 DOI: 10.1016/J.Biopsych.2010.09.022  0.745
2010 Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10431-40. PMID 20685985 DOI: 10.1523/Jneurosci.1445-10.2010  0.443
2010 Lipina TV, Niwa M, Jaaro-Peled H, Fletcher PJ, Seeman P, Sawa A, Roder JC. Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia. Genes, Brain, and Behavior. 9: 777-89. PMID 20618446 DOI: 10.1111/J.1601-183X.2010.00615.X  0.811
2010 Hayashi MA, Guerreiro JR, Charych E, Kamiya A, Barbosa RL, Machado MF, Campeiro JD, Oliveira V, Sawa A, Camargo AC, Brandon NJ. Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth. Molecular and Cellular Neurosciences. 44: 353-61. PMID 20462516 DOI: 10.1016/J.Mcn.2010.04.006  0.564
2010 Cascella NG, Fieldstone SC, Rao VA, Pearlson GD, Sawa A, Schretlen DJ. Gray-matter abnormalities in deficit schizophrenia. Schizophrenia Research. 120: 63-70. PMID 20452187 DOI: 10.1016/J.Schres.2010.03.039  0.383
2010 Hayashi-Takagi A, Sawa A. Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment. Brain Research Bulletin. 83: 140-6. PMID 20433911 DOI: 10.1016/j.brainresbull.2010.04.007  0.686
2010 Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences of the United States of America. 107: 5622-7. PMID 20212127 DOI: 10.1073/Pnas.0909284107  0.821
2010 Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, ... ... Sawa A, et al. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron. 65: 480-9. PMID 20188653 DOI: 10.1016/J.Neuron.2010.01.019  0.817
2010 Tajinda K, Ishizuka K, Colantuoni C, Morita M, Winicki J, Le C, Lin S, Schretlen D, Sawa A, Cascella NG. Neuronal biomarkers from patients with mental illnesses: a novel method through nasal biopsy combined with laser-captured microdissection. Molecular Psychiatry. 15: 231-2. PMID 20168323 DOI: 10.1038/Mp.2009.73  0.509
2010 Schretlen DJ, Vannorsdall TD, Winicki JM, Mushtaq Y, Hikida T, Sawa A, Yolken RH, Dickerson FB, Cascella NG. Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. Schizophrenia Research. 118: 224-31. PMID 20153952 DOI: 10.1016/J.Schres.2010.01.008  0.581
2010 Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, ... ... Sawa A, et al. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature Neuroscience. 13: 327-32. PMID 20139976 DOI: 10.1038/Nn.2487  0.82
2010 Ou XM, Stockmeier CA, Meltzer HY, Overholser JC, Jurjus GJ, Dieter L, Chen K, Lu D, Johnson C, Youdim MB, Austin MC, Luo J, Sawa A, May W, Shih JC. A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biological Psychiatry. 67: 855-63. PMID 20022592 DOI: 10.1016/J.Biopsych.2009.10.032  0.312
2010 Jaaro-Peled H, Ayhan Y, Pletnikov MV, Sawa A. Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophrenia Bulletin. 36: 301-13. PMID 19903746 DOI: 10.1093/Schbul/Sbp133  0.751
2010 Ishizuka K, Tajinda K, Colantuoni C, Morita M, Winicki J, Le C, Lin S, Schretlen D, Sawa A, Cascella NG. Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test. Neuroscience Research. 66: 106-10. PMID 19819272 DOI: 10.1016/J.Neures.2009.10.001  0.539
2010 Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, Yamada K. Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behavioural Brain Research. 206: 32-7. PMID 19716847 DOI: 10.1016/J.Bbr.2009.08.027  0.806
2010 Moghaddam B, Gaisler-Salomon I, O′Donnell P, Sawa A, Sokoloff P, Uhlhaas P. MAKING CONNECTIONS: ABNORMAL WHITE MATTER DEVELOPMENT IN THE EARLY STAGES OF SCHIZOPHRENIA Schizophrenia Research. 117: 110. DOI: 10.1016/J.Schres.2010.02.026  0.34
2010 Ishizuka K, Kano S, Colantuoni C, Schretlen D, Cascella NG, Sawa A. A translational approach for schizophrenia: Systematic cell/tissue engineering combined with detailed phenotypic characterization and molecular brain imaging Neuroscience Research. 68: e18. DOI: 10.1016/J.Neures.2010.07.315  0.775
2010 Horiuchi Y, Ishii S, Kano S, Ishizuka K, Okada Y, Colantuoni C, Valle D, Cascella NG, Akamatsu W, Sawa A, Okano H. Generation of induced pluripotent stem cells from patients with schizophrenia Neuroscience Research. 68: e314. DOI: 10.1016/J.Neures.2010.07.1395  0.768
2010 Shahani N, Young-Pearse T, Selkoe D, Sawa A. P2-247: Role of Disrupted-in-Schizophrenia-1 (DISC1) in amyloid precursor protein (APP) processing and Aβ generation Alzheimer's & Dementia. 6: S386-S387. DOI: 10.1016/J.Jalz.2010.05.1296  0.707
2009 Brandon NJ, Millar JK, Korth C, Sive H, Singh KK, Sawa A. Understanding the role of DISC1 in psychiatric disease and during normal development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12768-75. PMID 19828788 DOI: 10.1523/Jneurosci.3355-09.2009  0.384
2009 Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A. Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends in Neurosciences. 32: 485-95. PMID 19712980 DOI: 10.1016/J.Tins.2009.05.007  0.822
2009 Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Agrawal N, Aggrawal N, Hester L, Doré S, Snyder SH, Sawa A. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 63: 81-91. PMID 19607794 DOI: 10.1016/J.Neuron.2009.05.024  0.723
2009 Ayhan Y, Sawa A, Ross CA, Pletnikov MV. Animal models of gene-environment interactions in schizophrenia. Behavioural Brain Research. 204: 274-81. PMID 19379776 DOI: 10.1016/J.Bbr.2009.04.010  0.536
2009 Pletnikov M, Ayhan Y, Abazyan B, Pardo C, Sawa A, Vogel M, Ross C. S.16.04 DISC1 mouse model of gene-environment interactions in schizophrenia European Neuropsychopharmacology. 19. DOI: 10.1016/S0924-977X(09)70256-1  0.529
2009 Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Agrawal N, Hester L, Doré S, Snyder SH, Sawa A. GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation (DOI:10.1016/j.neuron.2009.05.024) Neuron. 63: 709. DOI: 10.1016/J.Neuron.2009.08.032  0.743
2009 Niwa M, Kamiya A, Murai R, Kubo K, Jaaro-Peled H, Lu L, Ozaki N, Nakajima K, Noda Y, Sawa A, Nabeshima T. Disturbance of Disrupted-in-Schizophrenia-1 during neurodevelopment develops phenotypes of psychiatric disorders related to dysfunction of the dopaminergic system Neuroscience Research. 65: S63. DOI: 10.1016/J.Neures.2009.09.189  0.812
2008 Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch LA, Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, ... ... Sawa A, et al. Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Molecular Psychiatry. 13: 1138-48, 1069. PMID 18762802 DOI: 10.1038/Mp.2008.101  0.686
2008 Kamiya A, Tan PL, Kubo K, Engelhard C, Ishizuka K, Kubo A, Tsukita S, Pulver AE, Nakajima K, Cascella NG, Katsanis N, Sawa A. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Archives of General Psychiatry. 65: 996-1006. PMID 18762586 DOI: 10.1001/Archpsyc.65.9.996  0.678
2008 Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, Sawa A. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature Cell Biology. 10: 866-73. PMID 18552833 DOI: 10.1038/Ncb1747  0.782
2008 Burdick KE, Kamiya A, Hodgkinson CA, Lencz T, DeRosse P, Ishizuka K, Elashvili S, Arai H, Goldman D, Sawa A, Malhotra AK. Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Human Molecular Genetics. 17: 2462-73. PMID 18469341 DOI: 10.1093/Hmg/Ddn146  0.665
2008 Kamiya A, Kitabatake Y, Sawa A. [Neurodevelopmental disturbance in the pathogenesis of major mental disorders]. Brain and Nerve = Shinkei Kenkyå« No Shinpo. 60: 445-52. PMID 18421986  0.568
2008 Liu Z, Wang X, Yu Y, Li X, Wang T, Jiang H, Ren Q, Jiao Y, Sawa A, Moran T, Ross CA, Montell C, Smith WW. A Drosophila model for LRRK2-linked parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 105: 2693-8. PMID 18258746 DOI: 10.1073/Pnas.0708452105  0.485
2008 Yasumoto F, Hayashi A, Kamiya A, Negishi T, Yoshikawa Y, Sawa A. Genetic manipulation of brain cultures from the primates: a novel tool for molecular studies of neuropsychiatric disorders. Molecular Psychiatry. 13: 116-8. PMID 18202692 DOI: 10.1038/Sj.Mp.4002113  0.547
2008 Hikida T, Mustafa AK, Maeda K, Fujii K, Barrow RK, Saleh M, Huganir RL, Snyder SH, Hashimoto K, Sawa A. Modulation of D-serine levels in brains of mice lacking PICK1. Biological Psychiatry. 63: 997-1000. PMID 18191108 DOI: 10.1016/J.Biopsych.2007.09.025  0.781
2008 Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ. How has DISC1 enabled drug discovery? Molecular and Cellular Neurosciences. 37: 187-95. PMID 18055216 DOI: 10.1016/J.Mcn.2007.10.006  0.738
2007 Oie S, Suenaga S, Sawa A, Kamiya A. Association between isolation sites of methicillin-resistant Staphylococcus aureus (MRSA) in patients with MRSA-positive body sites and MRSA contamination in their surrounding environmental surfaces. Japanese Journal of Infectious Diseases. 60: 367-9. PMID 18032836  0.414
2007 Hashimoto R, Tankou S, Takeda M, Sawa A. Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development. Drugs of Today (Barcelona, Spain : 1998). 43: 645-54. PMID 17940640 DOI: 10.1358/dot.2007.43.9.1088821  0.815
2007 Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y, Clapcote SJ, Hookway C, Morita M, Kamiya A, Tomoda T, Lipska BK, Roder JC, Pletnikov M, Porteous D, ... ... Sawa A, et al. Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Molecular Psychiatry. 12: 897-9. PMID 17895924 DOI: 10.1038/Sj.Mp.4002024  0.776
2007 Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, ... Sawa A, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences of the United States of America. 104: 14501-6. PMID 17675407 DOI: 10.1073/Pnas.0704774104  0.816
2007 Pletnikov MV, Xu Y, Ovanesov MV, Kamiya A, Sawa A, Ross CA. PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation. Neuroscience Research. 58: 234-44. PMID 17418909 DOI: 10.1016/J.Neures.2007.03.003  0.67
2007 Maruyama Y, Ando T, Honjo K, Shimoda M, Mochizuki H, Toda H, Kamiya A, Ishida N, Tomoda T, Sawa A, Furukubo-Tokunaga K. Overexpression of DISC1 impairs associative learning and arousal in Drosophila Neuroscience Research. 58: S123. DOI: 10.1016/J.Neures.2007.06.1287  0.493
2007 Hikida T, Jaaro-Peled H, Tankou S, Morita M, Pletnikov M, Kida S, Mori S, Sawa A. Production and analyses of mutant DISC1 transgenic mice: An animal model of schizophrenia Neuroscience Research. 58: S20. DOI: 10.1016/J.Neures.2007.06.117  0.802
2006 Kamiya A, Tomoda T, Chang J, Takaki M, Zhan C, Morita M, Cascio MB, Elashvili S, Koizumi H, Takanezawa Y, Dickerson F, Yolken R, Arai H, Sawa A. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Human Molecular Genetics. 15: 3313-23. PMID 17035248 DOI: 10.1093/Hmg/Ddl407  0.598
2006 Bord L, Wheeler J, Paek M, Saleh M, Lyons-Warren A, Ross CA, Sawamura N, Sawa A. Primate disrupted-in-schizophrenia-1 (DISC1): high divergence of a gene for major mental illnesses in recent evolutionary history. Neuroscience Research. 56: 286-93. PMID 16965828 DOI: 10.1016/J.Neures.2006.07.010  0.556
2006 Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, ... ... Sawa A, et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Human Molecular Genetics. 15: 3024-33. PMID 16959794 DOI: 10.1093/Hmg/Ddl244  0.603
2006 Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis MG, Sawa A. Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biological Psychiatry. 60: 929-35. PMID 16814263 DOI: 10.1016/J.Biopsych.2006.03.032  0.583
2006 Ishizuka K, Paek M, Kamiya A, Sawa A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biological Psychiatry. 59: 1189-97. PMID 16797264 DOI: 10.1016/J.Biopsych.2006.03.065  0.724
2006 Kirkpatrick B, Xu L, Cascella N, Ozeki Y, Sawa A, Roberts RC. DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. The Journal of Comparative Neurology. 497: 436-50. PMID 16736468 DOI: 10.1002/Cne.21007  0.514
2006 Hara MR, Cascio MB, Sawa A. GAPDH as a sensor of NO stress. Biochimica Et Biophysica Acta. 1762: 502-9. PMID 16574384 DOI: 10.1016/j.bbadis.2006.01.012  0.613
2006 Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, Mitkus S, Weickert CS, Matsumoto M, Sawa A, Straub RE, Vakkalanka R, Herman MM, Weinberger DR, Kleinman JE. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Human Molecular Genetics. 15: 1245-58. PMID 16510495 DOI: 10.1093/Hmg/Ddl040  0.434
2006 Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, Dawson TM, Sawa A, Snyder SH. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proceedings of the National Academy of Sciences of the United States of America. 103: 3887-9. PMID 16505364 DOI: 10.1073/Pnas.0511321103  0.789
2006 Bae BI, Hara MR, Cascio MB, Wellington CL, Hayden MR, Ross CA, Ha HC, Li XJ, Snyder SH, Sawa A. Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proceedings of the National Academy of Sciences of the United States of America. 103: 3405-9. PMID 16492755 DOI: 10.1073/Pnas.0511316103  0.778
2006 Hurt KJ, Sezen SF, Champion HC, Crone JK, Palese MA, Huang PL, Sawa A, Luo X, Musicki B, Snyder SH, Burnett AL. Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proceedings of the National Academy of Sciences of the United States of America. 103: 3440-3. PMID 16488973 DOI: 10.1073/Pnas.0511326103  0.711
2006 Fujii K, Maeda K, Hikida T, Mustafa AK, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir RL, Ujike H, Snyder SH, Sawa A. Serine racemase binds to PICK1: potential relevance to schizophrenia. Molecular Psychiatry. 11: 150-7. PMID 16314870 DOI: 10.1038/Sj.Mp.4001776  0.8
2006 Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease. 21: 381-91. PMID 16150600 DOI: 10.1016/J.Nbd.2005.07.014  0.524
2006 Lyons-Warren A, Chang JJ, Balkissoon R, Kamiya A, Garant M, Nurnberger J, Scheftner W, Reich T, McMahon FJ, Kelsoe J, Gershon E, Coryell W, Byerley W, Berrettini W, DePaulo R, ... ... Sawa A, et al. Erratum: Evidence of association between bipolar disorder and Citron on chromosome 12q24 Molecular Psychiatry. 11: 612-612. DOI: 10.1038/Sj.Mp.4001842  0.51
2005 Kamiya A, Kubo K, Tomoda T, Takaki M, Youn R, Ozeki Y, Sawamura N, Park U, Kudo C, Okawa M, Ross CA, Hatten ME, Nakajima K, Sawa A. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nature Cell Biology. 7: 1167-78. PMID 16299498 DOI: 10.1038/Ncb1328  0.735
2005 Sawa A, Snyder SH. Genetics. Two genes link two distinct psychoses. Science (New York, N.Y.). 310: 1128-9. PMID 16293746 DOI: 10.1126/science.1121114  0.494
2005 Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Human Molecular Genetics. 14: 3801-11. PMID 16239241 DOI: 10.1093/Hmg/Ddi396  0.567
2005 Zhang X, Tochigi M, Ohashi J, Maeda K, Kato T, Okazaki Y, Kato N, Tokunaga K, Sawa A, Sasaki T. Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population. Schizophrenia Research. 79: 175-80. PMID 16039834 DOI: 10.1016/j.schres.2005.05.023  0.361
2005 Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron. 47: 29-41. PMID 15996546 DOI: 10.1016/J.Neuron.2005.06.005  0.767
2005 Lyons-Warren A, Chang JJ, Balkissoon R, Kamiya A, Garant M, Nurnberger J, Scheftner W, Reich T, McMahon F, Kelsoe J, Gershon E, Coryell W, Byerley W, Berrettini W, Depaulo R, ... ... Sawa A, et al. Evidence of association between bipolar disorder and Citron on chromosome 12q24. Molecular Psychiatry. 10: 807-9. PMID 15983625 DOI: 10.1038/Sj.Mp.4001703  0.501
2005 Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nature Cell Biology. 7: 665-74. PMID 15951807 DOI: 10.1038/Ncb1268  0.775
2005 Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL. A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. Molecular Psychiatry. 10: 758-64. PMID 15940305 DOI: 10.1038/Sj.Mp.4001667  0.551
2005 Sawa A, Nagata E, Sutcliffe S, Dulloor P, Cascio MB, Ozeki Y, Roy S, Ross CA, Snyder SH. Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts. Neurobiology of Disease. 20: 267-74. PMID 15890517 DOI: 10.1016/J.Nbd.2005.02.013  0.641
2005 Sawamura N, Sawamura-Yamamoto T, Ozeki Y, Ross CA, Sawa A. A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proceedings of the National Academy of Sciences of the United States of America. 102: 1187-92. PMID 15657124 DOI: 10.1073/Pnas.0406543102  0.637
2004 Oie S, Ishitobi J, Sawa A, Tomita M, Kamiya A. In vitro bactericidal activity of antimicrobial agents against enterohaemorrhagic Escherichia coli. The Journal of Antimicrobial Chemotherapy. 54: 897-903. PMID 15472004 DOI: 10.1093/jac/dkh442  0.405
2004 Nagata E, Sawa A, Ross CA, Snyder SH. Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport. 15: 1325-8. PMID 15167559 DOI: 10.1097/01.Wnr.0000127073.66692.8F  0.569
2004 Sawa A, Pletnikov MV, Kamiya A. Neuron-glia interactions clarify genetic-environmental links in mental illness. Trends in Neurosciences. 27: 294-7. PMID 15165731 DOI: 10.1016/J.Tins.2004.03.012  0.611
2004 Ozeki Y, Okawa M, Sawa A. [DISC1 and schizophrenia]. Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. 24: 87-91. PMID 15164617  0.403
2004 Tsutsumi T, Holmes SE, McInnis MG, Sawa A, Callahan C, DePaulo JR, Ross CA, DeLisi LE, Margolis RL. Novel CAG/CTG repeat expansion mutations do not contribute to the genetic risk for most cases of bipolar disorder or schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 124: 15-9. PMID 14681907 DOI: 10.1002/Ajmg.B.20058  0.544
2004 Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A. Erratum: Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth (Proceedings of the National Academy of Sciences of the United States of America (January 7, 2003) 100, 1 (289-294)) Proceedings of the National Academy of Sciences of the United States of America. 101. DOI: 10.1073/Pnas.0405527101  0.732
2003 Oie S, Uematsu T, Sawa A, Mizuno H, Tomita M, Ishida S, Okano Y, Kamiya A. In vitro effects of combinations of antipseudomonal agents against seven strains of multidrug-resistant Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy. 52: 911-4. PMID 14585851 DOI: 10.1093/jac/dkg478  0.408
2003 Sawa A, Tomoda T, Bae BI. Mechanisms of neuronal cell death in Huntington's disease. Cytogenetic and Genome Research. 100: 287-95. PMID 14526190 DOI: 10.1159/000072864  0.721
2003 Sawa A, Kamiya A. Elucidating the pathogenesis of schizophrenia. Bmj (Clinical Research Ed.). 327: 632-3. PMID 14500408 DOI: 10.1136/Bmj.327.7416.632  0.61
2003 Blackshaw S, Eliasson MJ, Sawa A, Watkins CC, Krug D, Gupta A, Arai T, Ferrante RJ, Snyder SH. Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity. Neuroscience. 119: 979-90. PMID 12831857 DOI: 10.1016/S0306-4522(03)00217-3  0.782
2003 Sawa A, Snyder SH. Schizophrenia: neural mechanisms for novel therapies. Molecular Medicine (Cambridge, Mass.). 9: 3-9. PMID 12765334 DOI: 10.1007/Bf03402101  0.463
2003 Igarashi S, Morita H, Bennett KM, Tanaka Y, Engelender S, Peters MF, Cooper JK, Wood JD, Sawa A, Ross CA. Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation. Neuroreport. 14: 565-8. PMID 12657886 DOI: 10.1097/00001756-200303240-00007  0.498
2003 Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 100: 289-94. PMID 12506198 DOI: 10.1073/Pnas.0136913100  0.763
2003 Nucifora FC, Ellerby LM, Wellington CL, Wood JD, Herring WJ, Sawa A, Hayden MR, Dawson VL, Dawson TM, Ross CA. Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. The Journal of Biological Chemistry. 278: 13047-55. PMID 12464607 DOI: 10.1074/Jbc.M211224200  0.594
2003 Kirkpatrick B, Cascella N, Ozeki Y, Roberts R, Sawa A. DISC1-immunoreactive cells in the human brain Schizophrenia Research. 60: 72. DOI: 10.1016/S0920-9964(03)80599-6  0.474
2002 Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science (New York, N.Y.). 296: 692-5. PMID 11976442 DOI: 10.1126/science.1070532  0.52
2001 Luo HR, Saiardi A, Nagata E, Ye K, Yu H, Jung TS, Luo X, Jain S, Sawa A, Snyder SH. GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Neuron. 31: 439-51. PMID 11516400 DOI: 10.1016/S0896-6273(01)00384-1  0.4
2001 Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human Molecular Genetics. 10: 919-26. PMID 11309365 DOI: 10.1093/Hmg/10.9.919  0.582
2001 Saiardi A, Nagata E, Luo HR, Sawa A, Luo X, Snowman AM, Snyder SH. Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate. Proceedings of the National Academy of Sciences of the United States of America. 98: 2306-11. PMID 11226235 DOI: 10.1073/pnas.041614598  0.36
2000 Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2  0.753
2000 Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron. 28: 183-93. PMID 11086993 DOI: 10.1016/S0896-6273(00)00095-7  0.633
2000 Watkins CC, Sawa A, Jaffrey S, Blackshaw S, Barrow RK, Snyder SH, Ferris CD. Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy The Journal of Clinical Investigation. 106: 803. PMID 10995791 DOI: 10.1172/jci8273c1  0.77
2000 Doré S, Goto S, Sampei K, Blackshaw S, Hester LD, Ingi T, Sawa A, Traystman RJ, Koehler RC, Snyder SH. Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia. Neuroscience. 99: 587-92. PMID 10974422 DOI: 10.1016/S0306-4522(00)00216-5  0.613
2000 Watkins CC, Sawa A, Jaffrey S, Blackshaw S, Barrow RK, Snyder SH, Ferris CD. Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. The Journal of Clinical Investigation. 106: 373-84. PMID 10930440 DOI: 10.1172/Jci8273  0.773
2000 Blackshaw S, Sawa A, Sharp AH, Ross CA, Snyder SH, Khan AA. Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1375-9. PMID 10877830 DOI: 10.1096/Fj.14.10.1375  0.646
2000 Blackshaw S, Sawa A, Sharp AH, Ross CA, Snyder SH, Khan AA. Type 3 inositol 1,4,5‐trisphosphate receptor modulates cell death The Faseb Journal. 14: 1375-1379. DOI: 10.1096/fasebj.14.10.1375  0.602
2000 Watkins CC, Barrows RK, Sawa A, Snyder SH, Ferris CD. Loss of neuronal nitric oxide synthase (NNOS) in a model of diabetic gastropathy: Reversal by insulin therapy and PDE-V inhibitors Gastroenterology. 118: A669. DOI: 10.1016/S0016-5085(00)84811-8  0.666
1999 Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Barañano DE, Doré S, Poss KD, Snyder SH. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nature Cell Biology. 1: 152-7. PMID 10559901 DOI: 10.1038/11072  0.774
1999 Oie S, Sawa A, Kamiya A, Mizuno H. In-vitro effects of a combination of antipseudomonal antibiotics against multi-drug resistant Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy. 44: 689-91. PMID 10552987  0.403
1999 Sawa A, Wiegand GW, Cooper J, Margolis RL, Sharp AH, Lawler JF, Greenamyre JT, Snyder SH, Ross CA. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nature Medicine. 5: 1194-8. PMID 10502825 DOI: 10.1038/13518  0.579
1997 Sawa A, Khan AA, Hester LD, Snyder SH. Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Proceedings of the National Academy of Sciences of the United States of America. 94: 11669-74. PMID 9326668 DOI: 10.1073/PNAS.94.21.11669  0.437
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