Leonard C. Harrison - Publications

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265 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Harrison LC. The dark side of insulin: a primary autoantigen and instrument of self-destruction in type 1 diabetes. Molecular Metabolism. 101288. PMID 34242821 DOI: 10.1016/j.molmet.2021.101288  0.336
2020 Wang J, Bediaga N, Mallone R, Larger E, Harrison LC, Wentworth JM. Validation in the general population of a C-peptide estimate equation to measure beta cell function in recent-onset type 1 diabetes. Acta Diabetologica. PMID 32940799 DOI: 10.1007/S00592-020-01604-7  0.346
2020 Penno MA, Oakey H, Augustine P, Taranto M, Barry SC, Colman PG, Craig ME, Davis EA, Giles LC, Harris M, Haynes A, McGorm K, Morahan G, Morbey C, Rawlinson WD, ... ... Harrison LC, et al. Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study. Pediatric Diabetes. PMID 32430977 DOI: 10.1111/Pedi.13056  0.365
2020 Bandala-Sanchez E, Bediaga NG, Naselli G, Neale AM, Harrison LC. Siglec-10 expression is up-regulated in activated human CD4 T cells. Human Immunology. PMID 32046870 DOI: 10.1016/J.Humimm.2020.01.009  0.352
2019 Couper JJ, Harrison LC. Controversies in medicine: redefining the diagnosis of type 1 diabetes. The Medical Journal of Australia. 211: 157-159.e1. PMID 31318055 DOI: 10.5694/Mja2.50284  0.33
2019 Harbison JE, Roth-Schulze AJ, Giles LC, Tran CD, Ngui KM, Penno MA, Thomson RL, Wentworth JM, Colman PG, Craig ME, Morahan G, Papenfuss AT, Barry SC, Harrison LC, Couper JJ. Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes : a prospective cohort study. Pediatric Diabetes. PMID 31081243 DOI: 10.1111/Pedi.12865  0.334
2019 Wook Kim K, Allen DW, Briese T, Couper JJ, Barry SC, Colman PG, Cotterill AM, Davis EA, Giles LC, Harrison LC, Harris M, Haynes A, Horton JL, Isaacs SR, Jain K, et al. Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study. Open Forum Infectious Diseases. 6: ofz025. PMID 30815502 DOI: 10.1093/Ofid/Ofz025  0.327
2018 So M, Elso CM, Tresoldi E, Pakusch M, Pathiraja V, Wentworth JM, Harrison LC, Krishnamurthy B, Thomas HE, Rodda C, Cameron FJ, McMahon J, Kay TWH, Mannering SI. Proinsulin C-peptide is an autoantigen in people with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 30275329 DOI: 10.1073/Pnas.1809208115  0.396
2018 Wentworth JM, Bediaga NG, Giles LC, Ehlers M, Gitelman SE, Geyer S, Evans-Molina C, Harrison LC. Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables. Diabetologia. PMID 30167735 DOI: 10.1007/S00125-018-4722-Z  0.373
2018 Bandala-Sanchez E, G Bediaga N, Goddard-Borger ED, Ngui K, Naselli G, Stone NL, Neale AM, Pearce LA, Wardak A, Czabotar P, Haselhorst T, Maggioni A, Hartley-Tassell LA, Adams TE, Harrison LC. CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function. Proceedings of the National Academy of Sciences of the United States of America. PMID 29997173 DOI: 10.1073/Pnas.1722056115  0.334
2018 Zhang Y, Maksimovic J, Huang B, De Souza DP, Naselli G, Chen H, Zhang L, Weng K, Liang H, Xu Y, Wentworth JM, Huntington ND, Oshlack A, Gong S, Kallies A, ... ... Harrison LC, et al. Cord Blood CD8 T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner. Frontiers in Immunology. 9: 879. PMID 29922282 DOI: 10.3389/Fimmu.2018.00879  0.314
2018 Harbison JE, Roth-Schulze AJ, Barry SC, Tran CD, Ngui K, Penno MA, Wentworth J, Colman PG, Thomson R, Craig ME, Papenfuss AT, Giles L, Harrison LC, Couper J. Gut Microbiome Dysbiosis and Increased Intestinal Permeability in Australian Children with Islet Autoimmunity and Type 1 Diabetes Diabetes. 67. DOI: 10.2337/Db18-230-Or  0.338
2017 Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, ... ... Harrison LC, et al. Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology. 18: 1271. PMID 29044240 DOI: 10.1038/Ni1117-1271C  0.366
2017 Jiang FX, Harrison LC. Transient impairment of islet architectural development in pancreas-specific Bmpr1a-deleted prenatal mice involves reduced expression of E-cadherin. Stem Cells and Development. PMID 28922976 DOI: 10.1089/Scd.2017.0040  0.36
2017 Wentworth JM, Zhang JG, Bandala-Sanchez E, Naselli G, Liu C, Ritchie M, Smyth GK, O'Brien PE, Harrison LC. Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release. International Journal of Obesity (2005). PMID 28769120 DOI: 10.1038/Ijo.2017.180  0.309
2017 Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, ... ... Harrison LC, et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology. PMID 28346408 DOI: 10.1038/Ni.3713  0.392
2016 Ziegler AG, Bonifacio E, Powers AC, Todd JA, Harrison LC, Atkinson MA. Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease. Diabetes. 65: 3233-3239. PMID 27959859 DOI: 10.2337/Db16-0687  0.412
2016 Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia. PMID 27785529 DOI: 10.1007/S00125-016-4144-8  0.404
2016 Phillips JE, Couper JJ, Penno MA, Harrison LC. Type 1 diabetes: a disease of developmental origins. Pediatric Diabetes. PMID 27526948 DOI: 10.1111/Pedi.12425  0.341
2016 Auyeung P, Mittag D, Hodgkin PD, Harrison LC. Autoreactive T cells in chronic spontaneous urticaria target the IgE Fc receptor Iα subunit. The Journal of Allergy and Clinical Immunology. PMID 27417022 DOI: 10.1016/J.Jaci.2016.04.036  0.36
2016 Zhang Y, Feng ZP, Naselli G, Bell F, Wettenhall J, Auyeung P, Ellis JA, Ponsonby AL, Speed TP, Chong MM, Harrison LC. Corrigendum to 'MicroRNAs in CD4(+) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes' [J. Autoimmun. 68C (2016) 52-61]. Journal of Autoimmunity. PMID 27134182 DOI: 10.1016/J.Jaut.2016.04.002  0.374
2016 Pugliese A, Boulware D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molina C, Harrison LC, Schatz D, Palmer JP, Greenbaum C, Eisenbarth GS, Sosenko JM, et al. The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression. Diabetes. PMID 26822082 DOI: 10.2337/Db15-1105  0.353
2016 Zhang Y, Feng ZP, Naselli G, Bell F, Wettenhall J, Auyeung P, Ellis JA, Ponsonby AL, Speed TP, Chong MM, Harrison LC. MicroRNAs in CD4(+) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes. Journal of Autoimmunity. PMID 26786119 DOI: 10.1016/J.Jaut.2015.12.006  0.322
2015 Augstein P, Naselli G, Loudovaris T, Hawthorne WJ, Campbell P, Bandala-Sanchez E, Rogers K, Heinke P, Thomas HE, Kay TW, Harrison LC. Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells. Diabetes Research and Clinical Practice. PMID 26515908 DOI: 10.1016/J.Diabres.2015.10.010  0.441
2015 Jiang FX, Mishina Y, Baten A, Morahan G, Harrison LC. Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis. Biology Open. 4: 1016-23. PMID 26187948 DOI: 10.1242/Bio.011858  0.315
2014 Elkassaby S, Harrison LC, Mazzitelli N, Wentworth JM, Colman PG, Spelman T, Fourlanos S. A randomised controlled trial of high dose vitamin D in recent-onset type 2 diabetes. Diabetes Research and Clinical Practice. 106: 576-82. PMID 25438937 DOI: 10.1016/J.Diabres.2014.08.030  0.328
2014 Wentworth JM, Lukic V, Bahlo M, Finlay M, Nguyen C, Morahan G, Harrison LC. Maturity-onset diabetes of the young type 5 in a family with diabetes and mild kidney disease diagnosed by whole exome sequencing. Internal Medicine Journal. 44: 1137-40. PMID 25367728 DOI: 10.1111/Imj.12584  0.322
2014 Honeyman MC, Laine D, Zhan Y, Londrigan S, Kirkwood C, Harrison LC. Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. Plos One. 9: e106560. PMID 25181416 DOI: 10.1371/Journal.Pone.0106560  0.358
2014 Zhang Y, Kinkel S, Maksimovic J, Bandala-Sanchez E, Tanzer MC, Naselli G, Zhang JG, Zhan Y, Lew AM, Silke J, Oshlack A, Blewitt ME, Harrison LC. The polycomb repressive complex 2 governs life and death of peripheral T cells. Blood. 124: 737-49. PMID 24951427 DOI: 10.1182/Blood-2013-12-544106  0.344
2014 Fourlanos S, Elkassaby S, Varney MD, Colman PG, Harrison LC. Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes. Diabetes Research and Clinical Practice. 104: e69-71. PMID 24698405 DOI: 10.1016/J.Diabres.2014.03.009  0.314
2014 Bosco J, Nicholls K, McComish J, Bleasel K, Unglik G, Choo S, Flanagan K, Fulcher D, Naselli G, Martinuzzi E, Harrison L. Interferon gamma autoantibodies associated with susceptibility to disseminated mycobacterial infections Pathology. 46. DOI: 10.1097/01.Pat.0000443673.11555.83  0.313
2013 Penno MA, Couper JJ, Craig ME, Colman PG, Rawlinson WD, Cotterill AM, Jones TW, Harrison LC. Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. Bmc Pediatrics. 13: 124. PMID 23941366 DOI: 10.1186/1471-2431-13-124  0.404
2013 Harrison LC, Wentworth JM, Zhang Y, Bandala-Sanchez E, Böhmer RM, Neale AM, Stone NL, Naselli G, Bosco JJ, Auyeung P, Rashidi M, Augstein P, Morahan G. Antigen-based vaccination and prevention of type 1 diabetes. Current Diabetes Reports. 13: 616-23. PMID 23888323 DOI: 10.1007/S11892-013-0415-7  0.419
2013 Roep BO, Solvason N, Gottlieb PA, Abreu JR, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, et al. Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes. Science Translational Medicine. 5: 191ra82. PMID 23803704 DOI: 10.1089/Dia.2014.1510  0.43
2013 Bandala-Sanchez E, Zhang Y, Reinwald S, Dromey JA, Lee BH, Qian J, Böhmer RM, Harrison LC. T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nature Immunology. 14: 741-8. PMID 23685786 DOI: 10.1038/Ni.2610  0.379
2013 Coppieters KT, Harrison LC, von Herrath MG. Trials in type 1 diabetes: Antigen-specific therapies. Clinical Immunology (Orlando, Fla.). 149: 345-55. PMID 23490422 DOI: 10.1016/J.Clim.2013.02.002  0.382
2013 Chan AC, Leeansyah E, Cochrane A, Acoz YdUd, Mittag D, Harrison LC, Godfrey DI, Berzins SP. Ex‐vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4+ and CD4− subsets Clinical and Experimental Immunology. 172: 129-137. PMID 23480193 DOI: 10.1111/Cei.12045  0.349
2013 Brady JL, Sutherland RM, Hancock M, Kitsoulis S, Lahoud MH, Phillips PM, Hawthorne WJ, d'Apice AJ, Cowan PJ, Harrison LC, O'Connell PJ, Lew AM. Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation. 20: 100-9. PMID 23442186 DOI: 10.1111/Xen.12025  0.347
2013 Nguyen C, Varney MD, Harrison LC, Morahan G. Definition of high-risk type 1 diabetes HLA-DR and HLA-DQ types using only three single nucleotide polymorphisms. Diabetes. 62: 2135-40. PMID 23378606 DOI: 10.2337/Db12-1398  0.306
2012 Banakh I, Gonez LJ, Sutherland RM, Naselli G, Harrison LC. Adult pancreas side population cells expand after β cell injury and are a source of insulin-secreting cells. Plos One. 7: e48977. PMID 23152835 DOI: 10.1371/Journal.Pone.0048977  0.422
2012 Zhang Y, Bandala-Sanchez E, Harrison LC. Revisiting regulatory T cells in type 1 diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity. 19: 271-8. PMID 22732485 DOI: 10.1097/Med.0B013E328355A2D5  0.41
2012 Harrison LC. Insulin-specific vaccination for type 1 diabetes: a step closer? Human Vaccines & Immunotherapeutics. 8: 834-7. PMID 22495118 DOI: 10.4161/Hv.19673  0.347
2012 Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ. Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. The Journal of Biological Chemistry. 287: 16356-64. PMID 22447930 DOI: 10.1074/Jbc.M111.325951  0.418
2012 Micallef SJ, Li X, Schiesser JV, Hirst CE, Yu QC, Lim SM, Nostro MC, Elliott DA, Sarangi F, Harrison LC, Keller G, Elefanty AG, Stanley EG. INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells. Diabetologia. 55: 694-706. PMID 22120512 DOI: 10.1007/S00125-011-2379-Y  0.356
2011 Coughlan MT, Yap FY, Tong DC, Andrikopoulos S, Gasser A, Thallas-Bonke V, Webster DE, Miyazaki J, Kay TW, Slattery RM, Kaye DM, Drew BG, Kingwell BA, Fourlanos S, Groop PH, ... Harrison LC, et al. Advanced glycation end products are direct modulators of β-cell function. Diabetes. 60: 2523-32. PMID 21911745 DOI: 10.2337/Db10-1033  0.358
2011 Martinuzzi E, Afonso G, Gagnerault MC, Naselli G, Mittag D, Combadière B, Boitard C, Chaput N, Zitvogel L, Harrison LC, Mallone R. acDCs enhance human antigen-specific T-cell responses. Blood. 118: 2128-37. PMID 21715316 DOI: 10.1182/Blood-2010-12-326231  0.359
2011 Böhmer RM, Bandala-Sanchez E, Harrison LC. Forward light scatter is a simple measure of T-cell activation and proliferation but is not universally suited for doublet discrimination. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 79: 646-52. PMID 21695774 DOI: 10.1002/Cyto.A.21096  0.318
2011 Harrison LC. Persistently autoantibody-negative type 1 diabetes: rich pickings or much ado about nothing? Pediatric Diabetes. 12: 139-41. PMID 21518406 DOI: 10.1111/J.1399-5448.2011.00786.X  0.346
2011 Fourlanos S, Perry C, Gellert SA, Martinuzzi E, Mallone R, Butler J, Colman PG, Harrison LC. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes. 60: 1237-45. PMID 21307076 DOI: 10.2337/Db10-1360  0.416
2011 Dromey JA, Lee BH, Yu H, Young HE, Thearle DJ, Jensen KP, Mannering SI, Harrison LC. Generation and expansion of regulatory human CD4+ T-cell clones specific for pancreatic islet autoantigens Journal of Autoimmunity. 36: 47-55. PMID 21050716 DOI: 10.1016/J.Jaut.2010.10.005  0.398
2011 Bertin-Maghit S, Pang D, O'Sullivan B, Best S, Duggan E, Paul S, Thomas H, Kay TW, Harrison LC, Steptoe R, Thomas R. Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy. Diabetes. 60: 248-57. PMID 20980463 DOI: 10.2337/Db10-0104  0.405
2010 Wentworth JM, Naselli G, Brown WA, Doyle L, Phipson B, Smyth GK, Wabitsch M, O'Brien PE, Harrison LC. Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes. 59: 1648-56. PMID 20357360 DOI: 10.2337/Db09-0287  0.333
2010 Mittag D, Scholzen A, Varese N, Baxter L, Paukovics G, Harrison LC, Rolland JM, O'Hehir RE. The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 184: 4708-16. PMID 20308632 DOI: 10.4049/Jimmunol.0901036  0.344
2010 Honeyman MC, Stone NL, Falk BA, Nepom G, Harrison LC. Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens. Journal of Immunology (Baltimore, Md. : 1950). 184: 2204-10. PMID 20083660 DOI: 10.4049/Jimmunol.0900709  0.439
2010 Dromey JA, Bandala-Sanchez E, Reinwald S, Lee BH, Belov L, Harrison LC. A novel population of regulatory CD4 t cells is deficient after stimulation by autoantigen in type 1 diabetes Pathology. 42. DOI: 10.1097/01268031-201042001-00089  0.36
2010 Bertin-Maghit S, O'Sullivan B, Best S, Duggan E, Pang D, Thomas H, Kay T, Harrison L, Steptoe R, Thomas R. IL-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-helper-17 Cells at the Expense of Regulatory T cells: Implications for the Timing of Tolerizing Immunotherapy Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.294  0.34
2009 Wentworth JM, Fourlanos S, Harrison LC. Reappraising the stereotypes of diabetes in the modern diabetogenic environment. Nature Reviews. Endocrinology. 5: 483-9. PMID 19636326 DOI: 10.1038/Nrendo.2009.149  0.429
2009 Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC. The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. Clinical and Experimental Immunology. 156: 226-31. PMID 19292763 DOI: 10.1111/J.1365-2249.2009.03907.X  0.421
2009 Chan AC, Serwecinska L, Cochrane A, Harrison LC, Godfrey DI, Berzins SP. Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family. Clinical and Experimental Immunology. 156: 238-245. PMID 19250277 DOI: 10.1111/J.1365-2249.2009.03888.X  0.333
2009 Honeyman MC, Harrison LC. Congenital rubella, diabetes and HLA. Diabetologia. 52: 371-372. PMID 19020858 DOI: 10.1007/S00125-008-1213-7  0.383
2009 Couper JJ, Beresford S, Hirte C, Baghurst PA, Pollard A, Tait BD, Harrison LC, Colman PG. Weight gain in early life predicts risk of islet autoimmunity in children with a first-degree relative with type 1 diabetes. Diabetes Care. 32: 94-9. PMID 18835948 DOI: 10.2337/Dc08-0821  0.313
2008 Augstein P, Heinke P, Salzsieder E, Grimm R, Giebel J, Salzsieder C, Harrison LC. Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1. Diabetes & Vascular Disease Research. 5: 198-204. PMID 18777493 DOI: 10.3132/Dvdr.2008.032  0.339
2008 Góñez LJ, Naselli G, Banakh I, Niwa H, Harrison LC. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Molecular Medicine (Cambridge, Mass.). 14: 697-704. PMID 18769639 DOI: 10.2119/2008-00072.Gonez  0.325
2008 Fourlanos S, Harrison LC, Colman PG. The accelerator hypothesis and increasing incidence of type 1 diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity. 15: 321-5. PMID 18594271 DOI: 10.1097/Med.0B013E3283073A5A  0.404
2008 Harrison LC, Honeyman MC, Morahan G, Wentworth JM, Elkassaby S, Colman PG, Fourlanos S. Type 1 diabetes: lessons for other autoimmune diseases? Journal of Autoimmunity. 31: 306-10. PMID 18558477 DOI: 10.1016/J.Jaut.2008.04.026  0.422
2008 Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC, Colman PG, Harrison LC. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care. 31: 1546-9. PMID 18487476 DOI: 10.2337/Dc08-0239  0.335
2008 Krishnamurthy B, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, Santamaria P, Thomas HE, Kay TW. Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 4458-64. PMID 18354167 DOI: 10.4049/Jimmunol.180.7.4458  0.423
2008 Harrison LC. Vaccination against self to prevent autoimmune disease: the type 1 diabetes model. Immunology and Cell Biology. 86: 139-45. PMID 18180798 DOI: 10.1038/Sj.Icb.7100151  0.346
2008 Tait BD, Propert DN, Harrison L, Mandel T, Martin FIR. Interaction between HLA antigens and immunoglobulin (Gm) allotypes in susceptibility to type I diabetes Tissue Antigens. 27: 249-255. PMID 3726861 DOI: 10.1111/J.1399-0039.1986.Tb01529.X  0.34
2008 Dromey JA, Lee BH, Young HE, Mannering SI, Jensen KP, Thearle DJ, Fourlanos S, Belov L, Harrison LC. Immunity to self co-generates regulatory T cells Nature Precedings. 3: 1-1. DOI: 10.1038/Npre.2008.1774.1  0.327
2007 Micallef SJ, Li X, Janes ME, Jackson SA, Sutherland RM, Lew AM, Harrison LC, Elefanty AG, Stanley EG. Endocrine cells develop within pancreatic bud-like structures derived from mouse ES cells differentiated in response to BMP4 and retinoic acid. Stem Cell Research. 1: 25-36. PMID 19383384 DOI: 10.1016/J.Scr.2007.06.002  0.33
2007 Stankovic S, Zhan Y, Harrison LC. Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites. European Journal of Immunology. 37: 2226-33. PMID 17595677 DOI: 10.1002/Eji.200636761  0.327
2007 Zhan Y, Bourges D, Dromey JA, Harrison LC, Lew AM. The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells. International Immunology. 19: 455-63. PMID 17314081 DOI: 10.1093/Intimm/Dxm010  0.342
2007 Steptoe RJ, Ritchie JM, Wilson NS, Villadangos JA, Lew AM, Harrison LC. Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 2094-103. PMID 17277113 DOI: 10.4049/Jimmunol.178.4.2094  0.339
2007 Barker JM, McFann K, Harrison LC, Fourlanos S, Krischer J, Cuthbertson D, Chase HP, Eisenbarth GS. Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing. The Journal of Pediatrics. 150: 31-36.e6. PMID 17188609 DOI: 10.1016/J.Jpeds.2006.09.033  0.377
2006 Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. The Journal of Clinical Investigation. 116: 3258-65. PMID 17143333 DOI: 10.1172/Jci29602  0.408
2006 Narendran P, Neale AM, Lee BH, Ngui K, Steptoe RJ, Morahan G, Madsen O, Dromey JA, Jensen KP, Harrison LC. Proinsulin is encoded by an RNA splice variant in human blood myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 16430-5. PMID 17053071 DOI: 10.1073/Pnas.0607380103  0.358
2006 Locke NR, Stankovic S, Funda DP, Harrison LC. TCR gamma delta intraepithelial lymphocytes are required for self-tolerance. Journal of Immunology (Baltimore, Md. : 1950). 176: 6553-9. PMID 16709812 DOI: 10.4049/Jimmunol.176.11.6553  0.443
2006 Fourlanos S, Perry C, Stein MS, Stankovich J, Harrison LC, Colman PG. A clinical screening tool identifies autoimmune diabetes in adults. Diabetes Care. 29: 970-5. PMID 16644622 DOI: 10.2337/Dc05-2101  0.367
2006 Every AL, Kramer DR, Mannering SI, Lew AM, Harrison LC. Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes. Journal of Immunology (Baltimore, Md. : 1950). 176: 4608-15. PMID 16585551 DOI: 10.4049/Jimmunol.176.8.4608  0.38
2006 Knight KR, Uda Y, Findlay MW, Brown DL, Cronin KJ, Jamieson E, Tai T, Keramidaris E, Penington AJ, Rophael J, Harrison LC, Morrison WA. Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control. The Faseb Journal. 20: 565-567. PMID 16436466 DOI: 10.1096/Fj.05-4879Fje  0.342
2006 Mannering S, Thearle D, Jensen K, Williamson N, Purcell A, Harrison L. Su.31. An Enigmatic Human Cd4+ T-Cell Epitope in the C-Peptide of Proinsulin Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.458  0.315
2005 Harrison LC. The prospect of vaccination to prevent type 1 diabetes Human Vaccines.. 1: 143-150. PMID 17012869 DOI: 10.4161/Hv.1.4.1923  0.386
2005 Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW. The insulin A-chain epitope recognized by human T cells is posttranslationally modified. The Journal of Experimental Medicine. 202: 1191-7. PMID 16260488 DOI: 10.1084/Jem.20051251  0.441
2005 Fourlanos S, Dotta F, Greenbaum CJ, Palmer JP, Rolandsson O, Colman PG, Harrison LC. Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia. 48: 2206-12. PMID 16193284 DOI: 10.1007/S00125-005-1960-7  0.383
2005 Holland AM, Góñez LJ, Naselli G, Macdonald RJ, Harrison LC. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes. 54: 2586-95. PMID 16123346 DOI: 10.2337/Diabetes.54.9.2586  0.389
2005 Jiang FX, Harrison LC. Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells. Experimental Cell Research. 308: 114-22. PMID 15913604 DOI: 10.1016/J.Yexcr.2005.03.041  0.317
2005 Mannering SI, Dromey JA, Morris JS, Thearle DJ, Jensen KP, Harrison LC. An efficient method for cloning human autoantigen-specific T cells. Journal of Immunological Methods. 298: 83-92. PMID 15847799 DOI: 10.1016/J.Jim.2005.01.001  0.357
2005 Fourlanos S, Harrison LC. Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity. Pediatric Diabetes. 6: 3-4. PMID 15787894 DOI: 10.1111/J.1399-543X.2005.00094.X  0.334
2005 Jiang FX, Harrison LC. Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Differentiation; Research in Biological Diversity. 73: 45-9. PMID 15733067 DOI: 10.1111/J.1432-0436.2005.07301002.X  0.304
2005 O'Keeffe M, Brodnicki TC, Fancke B, Vremec D, Morahan G, Maraskovsky E, Steptoe R, Harrison LC, Shortman K. Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development. International Immunology. 17: 307-14. PMID 15684037 DOI: 10.1093/Intimm/Dxh210  0.364
2005 Steptoe RJ, Ritchie JM, Jones LK, Harrison LC. Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells. Diabetes. 54: 434-42. PMID 15677501 DOI: 10.2337/Diabetes.54.2.434  0.402
2004 Mannering SI, Morris JS, Stone NL, Jensen KP, VAN Endert PM, Harrison LC. CD4+ T cell proliferation in response to GAD and proinsulin in healthy, pre-diabetic, and diabetic donors. Annals of the New York Academy of Sciences. 1037: 16-21. PMID 15699488 DOI: 10.1196/Annals.1337.003  0.425
2004 Augstein P, Bahr J, Wachlin G, Heinke P, Berg S, Salzsieder E, Harrison LC. Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas. Journal of Autoimmunity. 23: 301-9. PMID 15571924 DOI: 10.1016/J.Jaut.2004.09.006  0.383
2004 Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC. Insulin resistance is a risk factor for progression to Type 1 diabetes Diabetologia. 47: 1661-1667. PMID 15480539 DOI: 10.1007/S00125-004-1507-3  0.389
2004 Harrison LC, Honeyman MC, Steele CE, Stone NL, Sarugeri E, Bonifacio E, Couper JJ, Colman PG. Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care. 27: 2348-55. PMID 15451899 DOI: 10.2337/Diacare.27.10.2348  0.45
2004 Zhan Y, Funda DP, Every AL, Fundova P, Purton JF, Liddicoat DR, Cole TJ, Godfrey DI, Brady JL, Mannering SI, Harrison LC, Lew AM. TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death. International Immunology. 16: 1315-21. PMID 15262900 DOI: 10.1093/Intimm/Dxh134  0.367
2004 Augstein P, Heinke P, Salzsieder E, Berg S, Rettig R, Salzsieder C, Harrison LC. Fas ligand down-regulates cytokine-induced Fas receptor expression on insulinoma (NIT-1), but not islet cells, from autoimmune nonobese diabetic mice. Endocrinology. 145: 2747-2752. PMID 15033908 DOI: 10.1210/En.2003-0754  0.409
2004 Steptoe RJ, Stankovic S, Lopaticki S, Jones LK, Harrison LC, Morahan G. Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation Journal of Autoimmunity. 22: 131-138. PMID 14987741 DOI: 10.1016/J.Jaut.2003.12.003  0.335
2004 Holland AM, Góñez LJ, Harrison LC. Progenitor cells in the adult pancreas. Diabetes-Metabolism Research and Reviews. 20: 13-27. PMID 14737742 DOI: 10.1002/Dmrr.430  0.341
2003 Fourlanos S, Colman PG, Harrison LC. Late-Onset Autoimmune Diabetes in Relatives of People with Type 1 Diabetes Annals of the New York Academy of Sciences. 1005: 370-373. PMID 14679094 DOI: 10.1196/Annals.1288.061  0.351
2003 Mannering SI, Morris JS, Jensen KP, Purcell AW, Honeyman MC, van Endert PM, Harrison LC. A sensitive method for detecting proliferation of rare autoantigen-specific human T cells. Journal of Immunological Methods. 283: 173-83. PMID 14659909 DOI: 10.1016/J.Jim.2003.09.004  0.396
2003 Harrison LC, Solly NR, Martinez NR, Bach. (Pro)insulin-specific regulatory T cells Novartis Foundation Symposium. 252: 132-145. PMID 14609216  0.333
2003 Mannering SI, Purcell AW, Honeyman MC, McCluskey J, Harrison LC. Human T-cells recognise N-terminally Fmoc-modified peptide. Vaccine. 21: 3638-46. PMID 12922093 DOI: 10.1016/S0264-410X(03)00402-X  0.302
2003 Jiang F, Harrison LC. Difference in Generating Mouse Pancreatic Epithelial Cell Colonies in Vitro Pancreas. 27: 204-206. PMID 12883273 DOI: 10.1097/00006676-200308000-00017  0.336
2003 Narendran P, Mannering SI, Harrison LC. Proinsulin - A pathogenic autoantigen in type 1 diabetes Autoimmunity Reviews. 2: 204-210. PMID 12848947 DOI: 10.1016/S1568-9972(03)00009-0  0.392
2003 Martinez NR, Augstein P, Moustakas AK, Papadopoulos GK, Gregori S, Adorini L, Jackson DC, Harrison LC. Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide Journal of Clinical Investigation. 111: 1365-1371. PMID 12727928 DOI: 10.1172/jci17166  0.437
2003 Steptoe RJ, Ritchie JM, Harrison LC. Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. The Journal of Clinical Investigation. 111: 1357-63. PMID 12727927 DOI: 10.1172/Jci15995  0.396
2003 Greenbaum CJ, Harrison LC. Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes. Diabetes. 52: 1059-1065. PMID 12716733 DOI: 10.2337/Diabetes.52.5.1059  0.381
2003 Herrath MGv, Harrison LC. Antigen-induced regulatory T cells in autoimmunity Nature. 3: 223. PMID 12658270 DOI: 10.1038/Nri1029  0.359
2003 Harrison LC, Solly NR, Martinez NR. (Pro)insulin-specific regulatory T cells. Novartis Foundation Symposium. 252: 132-145. DOI: 10.1002/0470871628.Ch10  0.428
2002 Colman PG, McNair PD, Gellert S, Kewming K, Schmidli RS, Steele CE, Harrison LC. Development of autoantibodies to islet antigens during childhood: implications for preclinical type 1 diabetes screening. Pediatric Diabetes. 3: 144-8. PMID 15016154 DOI: 10.1034/J.1399-5448.2002.30304.X  0.321
2002 Jiang F, Naselli G, Harrison LC. Distinct distribution of laminin and its integrin receptors in the pancreas. Journal of Histochemistry and Cytochemistry. 50: 1625-1632. PMID 12486084 DOI: 10.1177/002215540205001206  0.354
2002 Fox A, Mountford J, Braakhuis A, Harrison LC. High avidity antibodies to fetal pig pancreas endocrine cells transfer rejection but are not normally generated to fetal pig pancreas xenografts Xenotransplantation. 9: 382-392. PMID 12371934 DOI: 10.1034/J.1399-3089.2002.01008.X  0.352
2002 Coulson BS, Witterick PD, Tan Y, Hewish MJ, Mountford JN, Harrison LC, Honeyman MC. Growth of Rotaviruses in Primary Pancreatic Cells Journal of Virology. 76: 9537-9544. PMID 12186936 DOI: 10.1128/Jvi.76.18.9537-9544.2002  0.381
2002 Petrovsky N, Kyvik KO, Bonnevie-Nielsen V, Beck-Nielsen H, Green A, Harrison LC. Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes. Immunology. 106: 584-589. PMID 12153522 DOI: 10.1046/J.1365-2567.2002.01449.X  0.406
2002 Sutherland RM, McKenzie BS, Zhan Y, Corbett AJ, Fox-Marsh A, Georgiou HM, Harrison LC, Lew AM. Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing International Immunology. 14: 953-962. PMID 12147632 DOI: 10.1093/Intimm/Dxf063  0.387
2002 Steptoe RJ, Ritchie JM, Harrison LC. Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 5032-41. PMID 11994455 DOI: 10.4049/Jimmunol.168.10.5032  0.341
2002 Sutherland RM, Mountford JN, Allison J, Harrison LC, Lew AM. The non-immune RIP-Kb mouse is a useful host for islet transplantation, as the diabetes is spontaneous, mild and predictable. International Journal of Experimental Diabetes Research. 3: 37-45. PMID 11900278 DOI: 10.1080/15604280212530  0.401
2002 Hänninen A, Martinez NR, Davey GM, Heath WR, Harrison LC. Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity Journal of Clinical Investigation. 109: 261-267. PMID 11805138 DOI: 10.1172/Jci13720  0.364
2002 Adorini L, Gregori S, Harrison LC. Understanding autoimmune diabetes: insights from mouse models Trends in Molecular Medicine. 8: 31-38. PMID 11796264 DOI: 10.1016/S1471-4914(01)02193-1  0.435
2002 Jiang F, Harrison LC. Extracellular Signals and Pancreatic β -cell Development: A Brief Review Molecular Medicine. 8: 763-770. DOI: 10.1007/Bf03402081  0.367
2001 Harrison LC. Risk assessment, prediction and prevention of type 1 diabetes. Pediatric Diabetes. 2: 71-82. PMID 15016201 DOI: 10.1034/J.1399-5448.2001.002002071.X  0.443
2001 Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, Von Herrath M, Wegmann D, Wen L, Zekzer D. Report from the 1st International NOD Mouse T-Cell Workshop and the Follow-Up Mini-Workshop Diabetes. 50: 2459-2463. PMID 11679422 DOI: 10.2337/Diabetes.50.11.2459  0.377
2001 Chen W, Bergerot I, Elliott JF, Harrison LC, Abiru N, Eisenbarth GS, Delovitch TL. Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes Journal of Immunology. 167: 4926-4935. PMID 11673498 DOI: 10.4049/Jimmunol.167.9.4926  0.438
2001 Takahashi K, Honeyman MC, Harrison LC. Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific. Clinical Immunology. 99: 360-364. PMID 11358432 DOI: 10.1006/Clim.2001.5031  0.409
2001 Hänninen A, Braakhuis A, Heath WR, Harrison LC. Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route Diabetes. 50: 771-775. PMID 11289041 DOI: 10.2337/Diabetes.50.4.771  0.4
2001 Morahan G, Huang D, Ymer SI, Cancilla MR, Stephen K, Dabadghao P, Werther G, Tait BD, Harrison LC, Colman PG. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nature Genetics. 27: 218-21. PMID 11175794 DOI: 10.1038/84872  0.403
2001 Fox A, Mountford J, Braakhuis A, Harrison LC. Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection. Journal of Immunology. 166: 2133-2140. PMID 11160265 DOI: 10.4049/Jimmunol.166.3.2133  0.383
2001 Jiang F, Georges-Labouesse E, Harrison LC. Regulation of Laminin 1-Induced Pancreatic β -Cell Differentiation by α 6 Integrin and α -Dystroglycan Molecular Medicine. 7: 107-114. DOI: 10.1007/Bf03401944  0.308
2000 Colman PG, McNair P, King J, Caudwell J, Jankulovski C, Tait BD, Honeyman MC, Harrison LC. Screening for preclinical type 1 diabetes in a discrete population with an apparent increased disease incidence. Pediatric Diabetes. 1: 193-198. PMID 15016215 DOI: 10.1034/J.1399-5448.2000.001004193.X  0.4
2000 Harrison LC, Hafler DA. Antigen-specific therapy for autoimmune disease Current Opinion in Immunology. 12: 704-711. PMID 11102776 DOI: 10.1016/S0952-7915(00)00166-7  0.314
2000 Honeyman MC, Coulson BS, Stone NL, Gellert SA, Goldwater PN, Steele CE, Couper JJ, Tait BD, Colman PG, Harrison LC. Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes. 49: 1319-24. PMID 10923632 DOI: 10.2337/Diabetes.49.8.1319  0.418
2000 Honeyman MC, Coulson BS, Harrison LC. A novel subtype of type 1 diabetes mellitus. The New England Journal of Medicine. 342: 1835-1837. PMID 10866554 DOI: 10.1056/Nejm200006153422413  0.343
2000 Couper JJ, Kallincos N, Pollard A, Honeyman M, Prager P, Harrison LC, Rischmueller M. Toxic shock syndrome associated with newly diagnosed type I diabetes. Journal of Paediatrics and Child Health. 36: 279-282. PMID 10849234 DOI: 10.1046/J.1440-1754.2000.00475.X  0.402
2000 Colman PG, Steele C, Couper JJ, Beresford SJ, Powell T, Kewming K, Pollard A, Gellert S, Tait B, Honeyman M, Harrison LC. Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia. 43: 203-209. PMID 10753042 DOI: 10.1007/S001250050030  0.332
2000 Gregori S, Bono E, Gallazzi F, Hammer J, Harrison LC, Adorini L. The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library International Immunology. 12: 493-503. PMID 10744651 DOI: 10.1093/Intimm/12.4.493  0.3
2000 Kay TWH, Thomas HE, Harrison LC, Allison J. The beta cell in autoimmune diabetes: Many mechanisms and pathways of loss Trends in Endocrinology and Metabolism. 11: 11-15. PMID 10652500 DOI: 10.1016/S1043-2760(99)00210-6  0.409
1999 Harrison LC, Honeyman MC. Cow's milk and type 1 diabetes: the real debate is about mucosal immune function. Diabetes. 48: 1501-1507. PMID 10426365 DOI: 10.2337/Diabetes.48.8.1501  0.382
1999 Jiang FX, Cram DS, DeAizpurua HJ, Harrison LC. Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells. Diabetes. 48: 722-730. PMID 10102687 DOI: 10.2337/Diabetes.48.4.722  0.424
1998 Fox A, Koulmanda M, Mandel TE, van Rooijen N, Harrison LC. Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation. 66: 1407-16. PMID 9869080 DOI: 10.1097/00007890-199812150-00002  0.346
1998 Augstein P, Elefanty AG, Allison J, Harrison LC. Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia. 41: 1381-1388. PMID 9833948 DOI: 10.1007/S001250051080  0.447
1998 Honeyman MC, Brusic V, Stone NL, Harrison LC. Neural network-based prediction of candidate T-cell epitopes. Nature Biotechnology. 16: 966-9. PMID 9788355 DOI: 10.1038/Nbt1098-966  0.376
1998 Murphy VJ, Harrison LC, Rudert WA, Luppi P, Trucco M, Fierabracci A, Biro PA, Bottazzo GF. Retroviral superantigens and type 1 diabetes mellitus Cell. 95: 9-11. PMID 9778241 DOI: 10.1016/S0092-8674(00)81775-4  0.344
1998 Schmidli RS, Colman PG, Cui L, Yu WP, Kewming K, Jankulovski C, Harrison LC, Pallen CJ, DeAizpurua HJ. Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM. Autoimmunity. 28: 15-23. PMID 9754810 DOI: 10.3109/08916939808993841  0.387
1998 Couper JJ, Harrison LC, Aldis JJE, Colman PG, Honeyman MC, Ferrante A. IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes Human Immunology. 59: 493-499. PMID 9712353 DOI: 10.1016/S0198-8859(98)00040-8  0.373
1998 Colman P, McNair P, Margetts H, Schmidli R, Werther G, Alford F, Ward G, Tait B, Honeyman M, Harrison L. The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing The Medical Journal of Australia. 169: 81-84. PMID 9700342 DOI: 10.5694/J.1326-5377.1998.Tb140188.X  0.387
1998 Harrison LC. Type 1 diabetes. Molecular, cellular, and clinical immunology The Medical Journal of Australia. 169: 272-272. DOI: 10.5694/J.1326-5377.1998.Tb140258.X  0.334
1998 Honeyman MC, Stone NL, Harrison LC. T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents. Molecular Medicine. 4: 231-239. DOI: 10.1007/Bf03401920  0.409
1998 Augstein P, Stephens LA, Allison J, Elefanty AG, Ekberg M, Kay TWH, Harrison LC. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Molecular Medicine. 4: 495-501. DOI: 10.1007/Bf03401754  0.433
1997 Honeyman MC, Brusic V, Harrison LC. Strategies for identifying and predicting islet autoantigen T-cell epitopes in insulin-dependent diabetes mellitus Annals of Medicine. 29: 401-404. PMID 9453287 DOI: 10.3109/07853899708999369  0.37
1997 Yamashita K, Parish CR, Warren HS, Harrison LC. A multimeric form of soluble recombinant sheep LFA-3 (CD58) inhibits human T-cell proliferation. Immunology. 92: 39-44. PMID 9370922 DOI: 10.1046/J.1365-2567.1997.00317.X  0.356
1997 Takahashi K, Honeyman MC, Harrison LC. Dendritic Cells Generated from Human Blood in Granulocyte Macrophage-Colony Stimulating Factor and Interleukin-7 Human Immunology. 55: 103-116. PMID 9361962 DOI: 10.1016/S0198-8859(97)00094-3  0.307
1997 Noorchashm H, Kwok W, Rabinovitch A, Harrison LC. Immunology of IDDM Diabetologia. 40. PMID 9345646 DOI: 10.1007/Bf03168187  0.403
1997 Honeyman MC, Stone N, de Aizpurua H, Rowley MJ, Harrison LC. High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes. Journal of Autoimmunity. 10: 165-73. PMID 9185878 DOI: 10.1006/Jaut.1996.0124  0.455
1997 McColl GJ, Hammer J, Harrison LC. Absence of peripheral blood T cell responses to ‘shared epitope’ containing peptides in recent onset rheumatoid arthritis Annals of the Rheumatic Diseases. 56: 240-246. PMID 9165996 DOI: 10.1136/Ard.56.4.240  0.302
1997 Petrovsky N, Harrison LC. HLA Class II-associated polymorphism of interferon-γ production implications for HLA-disease association Human Immunology. 53: 12-16. PMID 9127142 DOI: 10.1016/S0198-8859(96)00271-6  0.315
1997 Harrison LC, Honeyman MC, Trembleau S, Gregori S, Gallazzi F, Augstein P, Brusic V, Hammer J, Adorini L. A Peptide-binding Motif for I-A g7 , the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice Journal of Experimental Medicine. 185: 1013-1021. PMID 9091575 DOI: 10.1084/Jem.185.6.1013  0.359
1997 Niwa H, Harrison LC, DeAizpurua HJ, Cram DS. Identification of pancreatic beta cell-related genes by representational difference analysis. Endocrinology. 138: 1419-1426. PMID 9075697 DOI: 10.1210/Endo.138.4.5066  0.342
1997 Manolios N, Collier S, Taylor J, Pollard J, Harrison LC, Bender V. T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease Nature Medicine. 3: 84-88. PMID 8986747 DOI: 10.1038/Nm0197-84  0.366
1997 French MB, Allison J, Cram DS, Thomas HE, Dempsey-Collier M, Silva A, Georgiou HM, Kay TW, Harrison LC, Lew AM. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice Diabetes. 46: 34-39. PMID 8971078 DOI: 10.2337/Diab.46.1.34  0.455
1996 Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes Journal of Experimental Medicine. 184: 2167-2174. PMID 8976172 DOI: 10.1084/Jem.184.6.2167  0.464
1996 Harrison L. Insulin-dependent diabetes: now for some good news. The Medical Journal of Australia. 165: 466-467. PMID 8937363 DOI: 10.5694/J.1326-5377.1996.Tb138607.X  0.385
1996 Nakagawa K, Harrison LC. The Potential Roles of Endogenous Retroviruses in Autoimmunity Immunological Reviews. 152: 193-236. PMID 8930674 DOI: 10.1111/J.1600-065X.1996.Tb00917.X  0.315
1996 Faulkner-Jones BE, Dempsey-Collier M, Mandel TE, Harrison LC. Both TH1 and TH2 cytokine mRNAs are expressed in the NOD mouse pancreas in vivo. Autoimmunity. 23: 99-110. PMID 8871765 DOI: 10.3109/08916939608995333  0.355
1996 Schmidli RS, Faulkner-Jones BE, Harrison LC, James RFL, DeAIZPURUA HJ. Cytokine Regulation Of Glutamate Decarboxylase Biosynthesis In Isolated Rat Islets Of Langerhans Biochemical Journal. 317: 713-719. PMID 8760354 DOI: 10.1042/Bj3170713  0.335
1996 Morahan G, Huang D, Tait BD, Colman PG, Harrison LC. Markers on Distal Chromosome 2q Linked to Insulin-Dependent Diabetes Mellitus Science. 272: 1811-1813. PMID 8650584 DOI: 10.1126/Science.272.5269.1811  0.36
1995 Petrovsky N, Harrison LC. Cytokine-based human whole blood assay for the detection of antigen-reactive T cells. Journal of Immunological Methods. 186: 37-46. PMID 7561146 DOI: 10.1016/0022-1759(95)00127-V  0.342
1995 Cram DS, Faulkner-Jones B, Kun J, Harrison LC. Glutamic acid decarboxylase-67 (GAD67): expression relative to GAD65 in human islets and mapping of autoantibody epitopes. Endocrinology. 136: 1111-1119. PMID 7532577 DOI: 10.1210/Endo.136.3.7532577  0.365
1995 Tait BD, Drummond BP, Varney MD, Harrison LC. HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus. European Journal of Immunogenetics. 22: 289-297. PMID 7495781 DOI: 10.1111/J.1744-313X.1995.Tb00245.X  0.32
1995 Harrison LC. Cytokines, Antigens and Regulation of Autoimmune Beta Cell Destruction in Non-Obese Diabetic (NOD) Mice Experimental Animals. 11: 1-1. DOI: 10.1538/Expanim1992.11.1  0.402
1995 Harrison LC. Antigen-Specific Therapy for Autoimmune Disease: Prospects for the Prevention of Insulin-Dependent Diabetes Molecular Medicine. 1: 722-727. DOI: 10.1007/Bf03401887  0.406
1995 Rudy G, Stone N, Harrison LC, Colman PG, McNair P, Brusic V, French MB, Honeyman MC, Tait B, Lew AM. Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Molecular Medicine. 1: 625-633. DOI: 10.1007/Bf03401603  0.383
1995 Honeyman MC, Harrison LC, Drummond B, Colman PG, Tait BD. Analysis of Families at Risk for Insulin-Dependent Diabetes Mellitus Reveals that HLA Antigens Influence Progression to Clinical Disease Molecular Medicine. 1: 576-582. DOI: 10.1007/Bf03401595  0.345
1994 Schmidli RS, DeAizpurua HJ, Harrison LC, Colman PG. Antibodies to glutamic acid decarboxylase in at-risk and clinical insulin-dependent diabetic subjects: relationship to age, sex and islet cell antibody status, and temporal profile Journal of Autoimmunity. 7: 55-66. PMID 8198702 DOI: 10.1006/Jaut.1994.1005  0.33
1994 Schmidli RS, Colman PG, Harrison LC. Do Glutamic Acid Decarboxylase Antibodies Improve the Prediction of IDDM in First-degree Relatives At Risk for IDDM? Journal of Autoimmunity. 7: 873-879. PMID 7888043 DOI: 10.1006/Jaut.1994.1071  0.369
1994 Chosich N, Rockett E, Harrison LC. Endogenous TNF production differs between high and low diabetes incidence non-obese diabetic (NOD) mice Autoimmunity. 18: 163-168. PMID 7858101 DOI: 10.3109/08916939409007992  0.348
1994 De Aizpurua HJ, French MB, Chosich N, Harrison LC. Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) mice Journal of Autoimmunity. 7: 643-653. PMID 7840856 DOI: 10.1006/Jaut.1994.1049  0.406
1994 Harrison LC, Honeyman MC, Deaizpurua HJ, Schmidli RS, Colman PG, Tait BD, Cram DS, Atkinson M, Leslie DRG. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Journal of Endocrinological Investigation. 17: 581-584. PMID 7829833 DOI: 10.1007/Bf03347753  0.365
1994 Harrison LC. Islet cell antibodies. Light at the end of the tube? Diabetes Care. 17: 1220-1222. PMID 7821149 DOI: 10.2337/Diacare.17.10.1220  0.303
1993 Yamashita K, Cram DS, Harrison LC. Molecular Cloning of Full-Length Glutamic Acid Decarboxylase 67 from Human Pancreas and Islets Biochemical and Biophysical Research Communications. 192: 1347-1352. PMID 8507202 DOI: 10.1006/Bbrc.1993.1564  0.34
1993 Honeyman MC, Cram DS, Harrison LC. Transcription Factor jun-B Is Target of Autoreactive T-Cells in IDDM Diabetes. 42: 626-630. PMID 8454114 DOI: 10.2337/Diab.42.4.626  0.352
1993 Frauman AG, Chu P, Harrison LC. Nonimmune thyroid destruction results from transgenic overexpression of an allogeneic major histocompatibility complex class I protein. Molecular and Cellular Biology. 13: 1554-1564. PMID 8441397 DOI: 10.1128/Mcb.13.3.1554  0.425
1993 Honeyman MC, Harrison LC. The immunologic insult in type 1 diabetes. Springer Seminars in Immunopathology. 14: 253-274. PMID 8438209 DOI: 10.1007/Bf00195977  0.35
1993 Honeyman MC, Cram DS, Harrison LC. Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes. Journal of Experimental Medicine. 177: 535-540. PMID 8426122 DOI: 10.1084/Jem.177.2.535  0.436
1993 Chosich N, Harrison LC. Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-Ag7) islet-derived CD4+ T-cell line. Diabetologia. 36: 716-721. PMID 8405738 DOI: 10.1007/Bf00401141  0.484
1993 Faulkner-Jones BE, Cram DS, Kun J, Harrison LC. Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat Endocrinology. 133: 2962-2972. PMID 8243324 DOI: 10.1210/Endo.133.6.8243324  0.356
1993 Harrison LC, Honeyman MC, DeAizpurua HJ, Schmidli RS, Colman PG, Tait BD, Cram DS. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes The Lancet. 341: 1365-1369. PMID 8098789 DOI: 10.1016/0140-6736(93)90940-I  0.453
1992 Kay TW, Campbell IL, Oxbrow L, Harrison LC. Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-gamma antibody. Diabetologia. 34: 779-85. PMID 1722764 DOI: 10.1007/Bf00408350  0.629
1992 Harrison LC, Chu SX, DeAizpurua HJ, Graham M, Honeyman MC, Colman PG. Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes. Journal of Clinical Investigation. 89: 1161-1165. PMID 1556180 DOI: 10.1172/Jci115698  0.44
1992 Peterson C, Campbell IL, Harrison LC. Lack of specificity of islet cell surface antibodies (ICSA) in IDDM Diabetes Research and Clinical Practice. 17: 33-42. PMID 1511659 DOI: 10.1016/0168-8227(92)90041-O  0.599
1992 Colman PG, Stewart V, Kean J, Koschmann M, Alford F, Ward G, Deam D, Harrison LC. Comparison of two commonly used standard IVGTTs Diabetes Care. 15: 1053-1055. PMID 1505309 DOI: 10.2337/Diacare.15.8.1053  0.303
1992 DeAizpurua HJ, Honeyman MC, Harrison LC. A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes. Journal of Autoimmunity. 5: 759-770. PMID 1489487 DOI: 10.1016/0896-8411(92)90191-R  0.412
1992 Harrison LC. Islet cell antigens in insulin-dependent diabetes : Pandora's box revisited Immunology Today. 13: 348-352. PMID 1466752 DOI: 10.1016/0167-5699(92)90170-C  0.435
1992 DeAizpurua HJ, Harrison LC. Glutamic acid decarboxylase in insulin-dependent diabetes mellitus. Diabetes \/ Metabolism Reviews. 8: 133-147. PMID 1425124 DOI: 10.1002/Dmr.5610080205  0.369
1992 Aizpurua HJD, Wilson YM, Harrison LC. Glutamic-Acid Decarboxylase Autoantibodies In Preclinical Insulin-Dependent Diabetes Proceedings of the National Academy of Sciences of the United States of America. 89: 9841-9845. PMID 1409709 DOI: 10.1073/Pnas.89.20.9841  0.346
1992 Muryoi T, Kasturi KN, Kafina MJ, Cram DS, Harrison LC, Sasaki T, Bona CA. Antitopoisomerase I monoclonal autoantibodies from scleroderma patients and tight skin mouse interact with similar epitopes. Journal of Experimental Medicine. 175: 1103-1109. PMID 1372644 DOI: 10.1084/Jem.175.4.1103  0.306
1992 Newman JD, Harrison LC, Eckardt GS, Jack I. Enhanced insulin-receptor tyrosine kinase activity associated with chromosomal translocation (1;19) in a pre-B-cell leukemia line. International Journal of Cancer. Journal International Du Cancer. 50: 500-4. PMID 1310491 DOI: 10.1002/Ijc.2910500328  0.375
1992 Frauman AG, Chu P, Allison J, Harrison LC. Overexpression of transgenic class I MHC alloantigen (H-2Kb) in the thyroid: acquired tolerance and nonimmune thyroid atrophy Pathology. 24: 43. DOI: 10.1016/S0031-3025(16)36030-5  0.372
1991 Bartholomeusz RK, Campbell IL, Harrison LC. A2B5-reactive ganglioside expression determines the differentiation stage and capacity of rat insulinoma (RIN) sublines. Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists. 32: 39-46. PMID 2090331 DOI: 10.1016/0922-3371(90)90097-G  0.54
1991 Couper JJ, Hudson I, Werther GA, Warne GL, Court JM, Harrison LC. Factors predicting residual β-cell function in the first year after diagnosis of childhood type 1 diabetes Diabetes Research and Clinical Practice. 11: 9-16. PMID 2019237 DOI: 10.1016/0168-8227(91)90135-Z  0.359
1991 Harrison LC, De Aizpurua H, Loudovaris T, Campbell IL, Cebon JS, Tait BD, Colman PG. Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes. Diabetes. 40: 1128-33. PMID 1936620 DOI: 10.2337/Diab.40.9.1128  0.582
1991 Tait BD, Harrison LC. 1 Overview: the major histocompatibility complex and insulin dependent diabetes mellitus BaillièRe's Clinical Endocrinology and Metabolism. 5: 211-228. PMID 1892463 DOI: 10.1016/S0950-351X(05)80124-7  0.343
1991 Clark S, Eckardt G, Siddle K, Harrison LC. Changes in insulin-receptor structure associated with trypsin-induced activation of the receptor tyrosine kinase. Biochemical Journal. 276: 27-33. PMID 1645531 DOI: 10.1042/Bj2760027  0.32
1991 Campbell IL, Kay TW, Oxbrow L, Harrison LC. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. Journal of Clinical Investigation. 87: 739-742. DOI: 10.1172/Jci115055  0.592
1991 Kay TW, Campbell IL, Harrison LC. Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse Journal of Autoimmunity. 4: 263-276. DOI: 10.1016/0896-8411(91)90023-6  0.57
1991 Campbell IL, Oxbrow L, Harrison LC. Reduction in insulitis following administration of IFN-γ and TNF-α in the NOD mouse Journal of Autoimmunity. 4: 249-262. DOI: 10.1016/0896-8411(91)90022-5  0.578
1990 Allison J, Harrison LC, Campbell IL, Miller JFAP. Major Histocompatibility Complex Molecules and the Beta Cell: Inferences from Transgenic Models Current Topics in Microbiology and Immunology. 156: 121-135. PMID 2199163 DOI: 10.1007/978-3-642-75239-1_9  0.58
1990 Bartholomeusz RK, Campbell IL, Harrison LC. A2B5-reactive ganglioside expression is an index of differentiation in rat insulinoma (RIN) cells. Endocrinology. 126: 1927-33. PMID 2156672 DOI: 10.1210/Endo-126-4-1927  0.539
1990 Bonifacio E, Boitard C, Gleichmann H, Shattock MA, Molenaar JL, Bottazzo GF, Assa S, Arnaiz-Villena A, Barbosa J, Betterle C, Beutner E, Bright G, Chapel H, Codina M, Dawkins R, ... ... Harrison L, et al. Assessment of precision, concordance, specificity, and sensitivity of islet cell antibody measurement in 41 assays Diabetologia. 33: 731-736. PMID 2073986 DOI: 10.1007/Bf00400345  0.336
1990 Campbell IL, Harrison LC. A new view of the beta cell as an antigen-presenting cell and immunogenic target. Journal of Autoimmunity. 53-62. PMID 1971174 DOI: 10.1016/S0896-8411(09)90010-5  0.608
1990 O'Brien RM, Cram DS, Coppel RL, Harrison LC. T-cell epitopes on the 70-kDa protein of the (U1)RNP complex in autoimmune rheumatologic disorders. Journal of Autoimmunity. 3: 747-757. PMID 1708263 DOI: 10.1016/S0896-8411(05)80041-1  0.344
1990 Tan K, Fairley SK, Jennens ID, Harrison LC. Abstract of the Ninth International Workshop on the Immunology of Diabetes held in Melbourne, Australia in November 1988Low dose vs conventional dose glucose for intravenous glucose tolerance testing Journal of Autoimmunity. 3: 98. DOI: 10.1016/0896-8411(90)90115-9  0.305
1990 Kay TW, Campbell IL, Harrison LC. Isolation and characterization of pancreatic T lymphocytes from the NOD mouse Journal of Autoimmunity. 3: 73. DOI: 10.1016/0896-8411(90)90065-Z  0.519
1990 Harrison L, Wilson A, Campbell I, Oxbrow L, Green M. ICRF-187 protects against the diabetogenic effect of low-dose streptozotocin Journal of Autoimmunity. 3: 68. DOI: 10.1016/0896-8411(90)90055-W  0.454
1990 Harrison L, Wilson A, Allison J, Campbell I, Miller J. Destruction of beta cells hyperexpressing a class I MHC transgene demonstrated by in situ hybridization Journal of Autoimmunity. 3: 67. DOI: 10.1016/0896-8411(90)90054-V  0.543
1990 Cook JJ, Hudson IL, Werther GA, Warne GL, Court JM, Harrison LC. Factors predicting residual beta cell function in children with newly-diagnosed type 1 diabetes Journal of Autoimmunity. 3: 56. DOI: 10.1016/0896-8411(90)90031-M  0.363
1990 Campbell IL, Iscaro A, Harrison LC, Simpson R. Interleukin-6 - effects on and production by beta cells Journal of Autoimmunity. 3: 51-52. DOI: 10.1016/0896-8411(90)90023-L  0.527
1990 Bartholomeusz R, Campbell IL, Harrison LC. Increased functional differentiation of A2B5 expressing sub-lines of the RIN-m5F cell Journal of Autoimmunity. 3: 46. DOI: 10.1016/0896-8411(90)90012-H  0.5
1989 Harrison LC, Campbell IL. Cytokines: an expanding network of immuno-inflammatory hormones. Molecular Endocrinology (Baltimore, Md.). 2: 1151-6. PMID 2851099 DOI: 10.1210/Mend-2-12-1151  0.525
1989 Newman JD, Eckardt GS, Boyd A, Harrison LC. Induction of the insulin receptor and other differentiation markers by sodium butyrate in the Burkitt lymphoma cell, Raji. Biochemical and Biophysical Research Communications. 161: 101-6. PMID 2786417 DOI: 10.1016/0006-291X(89)91566-0  0.398
1989 Harrison LC. Major histocompatibility genes and Type 1 (insulin-dependent) diabetes mellitus Diabetologia. 32: 218. PMID 2753248 DOI: 10.1007/Bf00265098  0.391
1989 Davidson PM, Campbell IL, Oxbrow L, Hutson JM, Harrison LC. Pancreatic beta cell proliferation in rabbits demonstrated by bromodeoxyuridine labeling. Pancreas. 4: 594-600. PMID 2682603 DOI: 10.1097/00006676-198910000-00011  0.578
1989 Newman JD, Harrison LC. Insulin receptor expression in Burkitt lymphoma cell lines. International Journal of Cancer. Journal International Du Cancer. 44: 467-73. PMID 2674026 DOI: 10.1002/Ijc.2910440315  0.416
1989 Newman JD, Campbell IL, Maher F, Harrison LC. Insulin receptor expression in the Burkitt lymphoma cells Daudi and Raji. Molecular Endocrinology (Baltimore, Md.). 3: 597-602. PMID 2664477 DOI: 10.1210/Mend-3-3-597  0.58
1989 Harrison LC, Campbell IL, Allison J, Miller JF. MHC molecules and beta-cell destruction. Immune and nonimmune mechanisms. Diabetes. 38: 815-8. PMID 2661283 DOI: 10.2337/Diab.38.7.815  0.585
1989 Cook JJ, Hudson I, Harrison LC, Dean B, Colman PG, Werther G, Warne GL, Court JM. Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes. Diabetes. 38: 779-783. PMID 2656346 DOI: 10.2337/Diab.38.6.779  0.371
1989 Kolb H, Bach JF, Eisenbarth GS, Harrison LC, Maclaren NK, Pozzilli P, Skyler JS, Stiller CR. Criteria for immune trials in type I diabetes. The Lancet. 334: 686. PMID 2570942 DOI: 10.1016/S0140-6736(89)90937-9  0.336
1989 Maher F, Clark S, Harrison LC. Chronic stimulation of glucose transporter gene expression in L6 myocytes mediated via the insulin-like growth factor-1 receptor. Molecular Endocrinology. 3: 2128-2135. PMID 2560811 DOI: 10.1210/Mend-3-12-2128  0.314
1989 Campbell IL, Harrison LC. Viruses and cytokines: evidence for multiple roles in pancreatic beta cell destruction in type 1 insulin-dependent diabetes mellitus. Journal of Cellular Biochemistry. 40: 57-66. PMID 2545735 DOI: 10.1002/Jcb.240400107  0.614
1989 Jonas HA, Cox AJ, Harrison LC. Delineation of atypical insulin receptors from classical insulin and type I insulin-like growth factor receptors in human placenta. Biochemical Journal. 257: 101-107. PMID 2537617 DOI: 10.1042/Bj2570101  0.332
1989 Kay TW, Campbell IL, Malcolm L, Harrison LC. Murine models of autoimmune diabetes: nonspecific cytotoxic lymphocytes derived from pancreatic islets in the presence of IL-2. Cellular Immunology. 120: 341-50. PMID 2524276 DOI: 10.1016/0008-8749(89)90202-5  0.615
1989 Campbell IL, Cutri A, Wilkinson D, Boyd AW, Harrison LC. Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection Proceedings of the National Academy of Sciences of the United States of America. 86: 4282-4286. PMID 2498883 DOI: 10.1073/Pnas.86.11.4282  0.612
1989 Harrison LC, Campbell IL, Allison J, Miller JF. MHC molecules and beta-cell destruction. Immune and nonimmune mechanisms Diabetes. 38: 815-818. DOI: 10.2337/diabetes.38.7.815  0.481
1989 BARTHOLOMEUSZ RK, CAMPBELL IL, HARRISON LC. Pancreatic Islet A2B5- and 3G5-Reactive Gangliosides are Markers of Differentiation in Rat Insulinoma Cells Endocrinology. 124: 2680-2685. DOI: 10.1210/Endo-124-6-2680  0.575
1988 Allison J, Campbell IL, Morahan G, Mandel TE, Harrison LC, Miller JF. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature. 333: 529-33. PMID 3287175 DOI: 10.1038/333529A0  0.617
1988 Tait BD, Mraz G, Harrison LC. Association of HLA-DQw3 (TA10−) with type I diabetes occurs with DR3/4 but not DR1/4 patients Diabetes. 37: 926-929. PMID 3260201 DOI: 10.2337/Diab.37.7.926  0.365
1988 Campbell IL, Oxbrow L, West J, Harrison LC. Regulation of MHC protein expression in pancreatic beta-cells by interferon-gamma and tumor necrosis factor-alpha. Molecular Endocrinology (Baltimore, Md.). 2: 101-7. PMID 3135484 DOI: 10.1210/MEND-2-2-101  0.486
1988 Leedman PJ, Davis S, Harrison LC. Diabetic amyotrophy: reassessment of the clinical spectrum Australian and New Zealand Journal of Medicine. 18: 768-773. PMID 3071993 DOI: 10.1111/J.1445-5994.1988.Tb00177.X  0.309
1988 Campbell IL, Harrison LC, Ashcroft RG, Jack I. Reovirus infection enhances expression of class I MHC proteins on human beta-cell and rat RINm5F cell. Diabetes. 37: 362-5. PMID 2836251 DOI: 10.2337/Diab.37.3.362  0.584
1987 Colman PG, Begley CG, Tait BD, Roberts-Thomson IC, Harrison LC. Evidence against an immunogenetic basis for diabetes in chronic pancreatitis. Australian and New Zealand Journal of Medicine. 17: 392-395. PMID 3325010 DOI: 10.1111/J.1445-5994.1987.Tb00071.X  0.415
1987 Campbell IL, Oxbrow L, Harrison LC. Interferon-gamma: pleiotropic effects on a rat pancreatic beta cell line. Molecular and Cellular Endocrinology. 52: 161-7. PMID 3040496 DOI: 10.1016/0303-7207(87)90109-2  0.602
1987 Bar RS, Harrison LC, Baxter RC, Boes M, Dake BL, Booth B, Cox A. Production of IGF-binding proteins by vascular endothelial cells. Biochemical and Biophysical Research Communications. 148: 734-9. PMID 2961328 DOI: 10.1016/0006-291X(87)90937-5  0.314
1987 Colman PG, Campbell IL, Kay TWH, Harrison LC. 64,000-Mr Autoantigen in Type I Diabetes: Evidence Against Its Surface Location on Human Islets Diabetes. 36: 1432-1440. DOI: 10.2337/Diab.36.12.1432  0.594
1986 Campbell IL, Bizilj K, Colman PG, Tuch BE, Harrison LC. Interferon-gamma induces the expression of HLA-A,B,C but not HLA-DR on human pancreatic beta-cells. The Journal of Clinical Endocrinology and Metabolism. 62: 1101-9. PMID 3084532 DOI: 10.1210/Jcem-62-6-1101  0.578
1986 Jonas HA, Newman JD, Harrison LC. An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors. Proceedings of the National Academy of Sciences of the United States of America. 83: 4124-8. PMID 3012553 DOI: 10.1073/Pnas.83.12.4124  0.325
1986 Assan R, Bach JF, Czernichow P, Dupré J, Stiller CR, Eisenbarth GS, Gries FA, Kolb H, Harrison LC, Lafferty K, Mclaren NK, Nerup J, Rabinovitch A, Skyler JS. Immunosuppressive drugs in diabetes. The Lancet. 328: 1097-1097. PMID 2877246 DOI: 10.1016/S0140-6736(86)90491-5  0.306
1986 Campbell IL, Harrison LC, Colman PG, Papaioannou J, Ashcroft RG. Expression of Class I MHC Proteins on RIN-m5F Cells Is Increased by Interferon-  and Lymphokine-Conditioned Medium Diabetes. 35: 1225-1228. DOI: 10.2337/Diab.35.11.1225  0.507
1985 Newman JD, Harrison LC. Homogeneous bivalent insulin receptor: purification using insulin coupled to 1,1'-carbonyldiimidazole activated-agarose. Biochemical and Biophysical Research Communications. 132: 1059-65. PMID 4074346 DOI: 10.1016/0006-291X(85)91914-X  0.324
1985 Clark S, Harrison LC. Structure of covalent insulin-receptor complexes (I-S-S-R) in isolated rat adipocytes and human placental membranes Biochemical Journal. 229: 513-519. PMID 4038277 DOI: 10.1042/Bj2290513  0.325
1985 Campbell IL, Wong GH, Schrader JW, Harrison LC. Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells. Diabetes. 34: 1205-9. PMID 3930327 DOI: 10.2337/Diab.34.11.1205  0.574
1985 Harrison LC, Colman PG, Dean B, Baxter R, Martin FIR. Increase in Remission Rate in Newly Diagnosed Type I Diabetic Subjects Treated with Azathioprine Diabetes. 34: 1306-1308. PMID 3905463 DOI: 10.2337/Diab.34.12.1306  0.333
1985 Colman PG, Harrison LC, Tait BD. Insulin secretion and immuno-genetic markers in diabetics with 'secondary failure' of oral hypoglycemic agents. Australian and New Zealand Journal of Medicine. 15: 209-212. PMID 3896215 DOI: 10.1111/J.1445-5994.1985.Tb04008.X  0.416
1985 Harrison LC, Dean B, Peluso I, Clark S, Ward G. Insulin resistance, acanthosis nigricans, and polycystic ovaries associated with a circulating inhibitor of postbinding insulin action. The Journal of Clinical Endocrinology and Metabolism. 60: 1047-1052. PMID 3884647 DOI: 10.1210/Jcem-60-5-1047  0.35
1985 Campbell IL, Harrison LC, Ley CJ, Colman PG, Ellis DW. Nesidioblastosis and multifocal pancreatic islet cell hyperplasia in an adult. Clinicopathologic features and in vitro pancreatic studies. American Journal of Clinical Pathology. 84: 534-41. PMID 2863976 DOI: 10.1093/Ajcp/84.4.534  0.591
1985 CAMPBELL IL, COLMAN PG, HARRISON L. Adult Human Pancreatic Islet Cells in Tissue Culture: Function and Immunoreactivity* The Journal of Clinical Endocrinology & Metabolism. 61: 681-685. DOI: 10.1210/Jcem-61-4-681  0.573
1983 Karlsson F, Harrison LC, Kahn CR, Itin A, Roth J. Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients. Diabetologia. 23: 488-93. PMID 6759274 DOI: 10.1007/Bf00254296  0.346
1983 Van Obberghen E, Grunfeld C, Harrison LC, Karlsson A, Muggeo M, Kahn CR. Autoantibodies to the insulin receptor and insulin-resistant diabetes. Hormone Research. 16: 280-8. PMID 6757094 DOI: 10.1159/000179515  0.367
1983 Plehwe WE, Williams PF, Caterson ID, Harrison LC, Turtle JR. Calcium-dependence of insulin receptor phosphorylation. Biochemical Journal. 214: 361-366. PMID 6351850 DOI: 10.1042/Bj2140361  0.324
1982 Harrison LC, Itin A, Kasuga M, Obberghen EV. The insulin receptor on the human lymphocyte: insulin-induced down-regulation of 126,000 and 90,000 glycosylated subunits. Diabetologia. 22: 233-238. PMID 6980155 DOI: 10.1007/Bf00281297  0.319
1981 Kasuga M, van Obberghen E, Yamada KM, Harrison LC. Autoantibodies against the insulin receptor recognize the insulin binding subunits of an oligomeric receptor. Diabetes. 30: 354-7. PMID 7202866 DOI: 10.2337/Diab.30.4.354  0.326
1981 Obberghen EV, Ksauga M, Cam AL, Hedo JA, Itin A, Harrison LC. Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 78: 1052-1056. PMID 6940121 DOI: 10.1073/Pnas.78.2.1052  0.346
1979 Harrison LC, Flier J, Itin A, Kahn CR, Roth J. Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function. Science (New York, N.Y.). 203: 544-7. PMID 83675 DOI: 10.1126/Science.83675  0.344
1976 Harrison LC, King-Roach AP. Cell size and glucose oxidation rate in adipose tissue from non-diabetic and diabetic obese human subjects. Clinical Science. 50: 171-175. PMID 1253528 DOI: 10.1042/Cs0500171  0.398
1976 Harrison LC, Martin FI, Melick RA. Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects. Journal of Clinical Investigation. 58: 1435-1441. PMID 993352 DOI: 10.1172/Jci108599  0.358
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