David A. Hafler - Publications

Affiliations: 
Neurology Yale University School of Medicine, New Haven, CT 
Area:
Multiple Sclerosis and Neuroimmunology
Website:
http://medicine.yale.edu/neurology/people/david_hafler.profile

277 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. Jci Insight. 2. PMID 28878118 DOI: 10.1172/jci.insight.92321  0.4
2016 Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, ... ... Hafler DA, et al. Power Estimation for Non-Standardized Multisite Studies. Neuroimage. PMID 27039700 DOI: 10.1016/j.neuroimage.2016.03.051  0.84
2015 Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. The Journal of Clinical Investigation. 125: 4212-22. PMID 26524592 DOI: 10.1172/JCI81151  0.84
2015 Housley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clinical Immunology (Orlando, Fla.). 161: 51-8. PMID 26143623 DOI: 10.1016/j.clim.2015.06.015  0.84
2015 Marson A, Housley WJ, Hafler DA. Genetic basis of autoimmunity. The Journal of Clinical Investigation. 125: 2234-41. PMID 26030227 DOI: 10.1172/JCI78086  0.84
2015 Hafler DA, Astier AL. Editorial: T cell regulation by the environment. Frontiers in Immunology. 6: 229. PMID 26029214 DOI: 10.3389/fimmu.2015.00229  0.84
2015 Kitz A, Hafler DA. Thymic selection: to thine own self be true. Immunity. 42: 788-9. PMID 25992854 DOI: 10.1016/j.immuni.2015.05.007  0.84
2015 Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Science Translational Medicine. 7: 287ra74. PMID 25972006 DOI: 10.1126/scitranslmed.aaa8038  0.84
2015 Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A. Monoallelic expression of the human FOXP2 speech gene. Proceedings of the National Academy of Sciences of the United States of America. 112: 6848-54. PMID 25422445 DOI: 10.1073/pnas.1411270111  0.84
2015 Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA. TLR7 induces anergy in human CD4(+) T cells. Nature Immunology. 16: 118-28. PMID 25401424 DOI: 10.1038/ni.3036  0.84
2015 Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, ... ... Hafler DA, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 518: 337-43. PMID 25363779 DOI: 10.1038/nature13835  0.4
2015 Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aaa9223  0.84
2015 Ransohoff RM, Hafler DA, Lucchinetti CF. Multiple sclerosis - A quiet revolution Nature Reviews Neurology. 11: 134-142. DOI: 10.1038/nrneurol201514  0.84
2014 Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, ... Hafler DA, et al. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine. 6: 248ra107. PMID 25100741 DOI: 10.1126/scitranslmed.3008879  0.84
2014 Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA. Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells. European Journal of Immunology. 44: 2703-11. PMID 24838857 DOI: 10.1002/eji.201344392  0.84
2014 Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. The Journal of Clinical Investigation. 124: 2513-22. PMID 24812667 DOI: 10.1172/JCI72973  0.84
2014 Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, ... ... Hafler DA, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (New York, N.Y.). 344: 519-23. PMID 24786080 DOI: 10.1126/science.1249547  0.84
2014 Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 40: 569-81. PMID 24745333 DOI: 10.1016/j.immuni.2014.02.012  0.84
2014 Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, ... ... Hafler DA, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 40: 477-89. PMID 24745332 DOI: 10.1016/j.immuni.2014.04.004  0.84
2014 Liu BS, Cao Y, Huizinga TW, Hafler DA, Toes RE. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. European Journal of Immunology. 44: 2121-9. PMID 24737107 DOI: 10.1002/eji.201344341  0.84
2014 Kleinewietfeld M, Hafler DA. Regulatory T cells in autoimmune neuroinflammation. Immunological Reviews. 259: 231-44. PMID 24712469 DOI: 10.1111/imr.12169  0.84
2014 Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics (Oxford, England). 30: 1930-2. PMID 24618469 DOI: 10.1093/bioinformatics/btu138  0.84
2014 Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, ... Hafler DA, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (New York, N.Y.). 343: 1246980. PMID 24604203 DOI: 10.1126/science.1246980  0.84
2014 Brusic V, Gottardo R, Kleinstein SH, Davis MM. Computational resources for high-dimensional immune analysis from the Human Immunology Project Consortium. Nature Biotechnology. 32: 146-8. PMID 24441472 DOI: 10.1038/nbt.2777  0.84
2014 Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of "Western diet" in inflammatory autoimmune diseases. Current Allergy and Asthma Reports. 14: 404. PMID 24338487 DOI: 10.1007/s11882-013-0404-6  0.84
2013 Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Frontiers in Immunology. 4: 358. PMID 24298272 DOI: 10.3389/fimmu.2013.00358  0.84
2013 Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, ... Hafler DA, et al. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. Plos Genetics. 9: e1003926. PMID 24278027 DOI: 10.1371/journal.pgen.1003926  0.84
2013 Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Seminars in Immunology. 25: 305-12. PMID 24211039 DOI: 10.1016/j.smim.2013.10.009  0.84
2013 Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 81: 1891-9. PMID 24174586 DOI: 10.1212/01.wnl.0000436612.66328.8a  0.84
2013 Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. Journal of Immunology (Baltimore, Md. : 1950). 191: 3673-80. PMID 23980210 DOI: 10.4049/jimmunol.1300945  0.84
2013 Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology. 81: 956-63. PMID 23921886 DOI: 10.1212/WNL.0b013e3182a43b48  0.84
2013 Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE. Microbial reprogramming inhibits Western diet-associated obesity. Plos One. 8: e68596. PMID 23874682 DOI: 10.1371/journal.pone.0068596  0.84
2013 Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. The Journal of Clinical Investigation. 123: 2737-41. PMID 23676463 DOI: 10.1172/JCI68775  0.84
2013 Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 19: 1726-33. PMID 23612879 DOI: 10.1177/1352458513485653  0.84
2013 Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 496: 518-22. PMID 23467095 DOI: 10.1038/nature11868  0.84
2013 Cotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis. Trends in Immunology. 34: 22-6. PMID 23031829 DOI: 10.1016/j.it.2012.09.001  0.84
2013 Gawlik BB, Hafler DA. Regulatory T cells in MS Multiple Sclerosis Immunology: a Foundation For Current and Future Treatments. 27-47. DOI: 10.1007/978-1-4614-7953-6_2  0.84
2012 Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Science Translational Medicine. 4: 153ra131. PMID 23019656 DOI: 10.1126/scitranslmed.3004186  0.84
2012 Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nature Immunology. 13: 991-9. PMID 22961052 DOI: 10.1038/ni.2416  0.84
2012 Lowther DE, Hafler DA. Regulatory T cells in the central nervous system. Immunological Reviews. 248: 156-69. PMID 22725960 DOI: 10.1111/j.1600-065X.2012.01130.x  0.84
2012 Kickler K, Maltby K, Ni Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL. Prostaglandin E2 affects T cell responses through modulation of CD46 expression. Journal of Immunology (Baltimore, Md. : 1950). 188: 5303-10. PMID 22544928 DOI: 10.4049/jimmunol.1103090  0.84
2012 Hafler DA. Perspective: Deconstructing a disease. Nature. 484: S6. PMID 22509507 DOI: 10.1038/nature11100  0.84
2012 Nylander A, Hafler DA. Multiple sclerosis. The Journal of Clinical Investigation. 122: 1180-8. PMID 22466660 DOI: 10.1172/JCI58649  0.84
2012 Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 axis regulates human T cell function. Journal of Immunology (Baltimore, Md. : 1950). 188: 3869-75. PMID 22427644 DOI: 10.4049/jimmunol.1103627  0.84
2012 Costantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC self-antigen presentation in human B and T lymphocytes. Plos One. 7: e29805. PMID 22299025 DOI: 10.1371/journal.pone.0029805  0.84
2012 Pelletier D, Hafler DA. Fingolimod for multiple sclerosis. The New England Journal of Medicine. 366: 339-47. PMID 22276823 DOI: 10.1056/NEJMct1101691  0.84
2012 Fernando MM, Freudenberg J, Lee A, Morris DL, Boteva L, Rhodes B, Gonzalez-Escribano MF, Lopez-Nevot MA, Navarra SV, Gregersen PK, Martin J, Vyse TJ. Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G. Annals of the Rheumatic Diseases. 71: 777-84. PMID 22233601 DOI: 10.1136/annrheumdis-2011-200808  0.84
2012 Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 109: 1607-12. PMID 22160692 DOI: 10.1073/pnas.1117194109  0.84
2012 Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4 + T cell proliferation (Journal of Immunology (2011) 187, (3286-3291)) Journal of Immunology. 189: 2063. DOI: 10.4049/jimmunol.1290044  0.84
2011 Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, ... ... Hafler DA, et al. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Annals of Neurology. 70: 897-912. PMID 22190364 DOI: 10.1002/ana.22609  0.84
2011 Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, et al. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. Plos One. 6: e24593. PMID 21980348 DOI: 10.1371/journal.pone.0024593  0.84
2011 Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, ... ... Hafler DA, et al. Pervasive sharing of genetic effects in autoimmune disease. Plos Genetics. 7: e1002254. PMID 21852963 DOI: 10.1371/journal.pgen.1002254  0.84
2011 Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. Journal of Immunology (Baltimore, Md. : 1950). 187: 3286-91. PMID 21849685 DOI: 10.4049/jimmunol.1100626  0.84
2011 Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, ... ... Hafler DA, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 476: 214-9. PMID 21833088 DOI: 10.1038/nature10251  0.48
2011 Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 187: 1039-46. PMID 21653833 DOI: 10.4049/jimmunol.1001543  0.84
2011 Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL. Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Human Molecular Genetics. 20: 3517-24. PMID 21653641 DOI: 10.1093/hmg/ddr250  0.84
2011 . The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study. Plos One. 6: e18813. PMID 21552549 DOI: 10.1371/journal.pone.0018813  0.84
2011 Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nature Medicine. 17: 673-5. PMID 21540856 DOI: 10.1038/nm.2389  0.84
2011 Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der Pouw Kraan TC, van der PouwKraan TC, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, et al. Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis. Genes and Immunity. 12: 466-72. PMID 21471993 DOI: 10.1038/gene.2011.18  0.84
2011 Dominguez-Villar M, Hafler DA. Immunology. An innate role for IL-17. Science (New York, N.Y.). 332: 47-8. PMID 21454778 DOI: 10.1126/science.1205311  0.84
2011 Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology. 233: 245-8. PMID 21353315 DOI: 10.1016/j.jneuroim.2011.01.010  0.84
2011 Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD. A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes and Immunity. 12: 335-40. PMID 21346779 DOI: 10.1038/gene.2011.3  0.84
2011 Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 186: 3317-26. PMID 21300823 DOI: 10.4049/jimmunol.1002502  0.84
2011 Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JR. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Medicine. 3: 3. PMID 21244703 DOI: 10.1186/gm217  0.84
2011 Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain : a Journal of Neurology. 134: 534-41. PMID 21216828 DOI: 10.1093/brain/awq350  0.84
2011 Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL. Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. Journal of Neuroimmunology. 233: 168-74. PMID 21115201 DOI: 10.1016/j.jneuroim.2010.10.038  0.84
2011 Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosensors & Bioelectronics. 26: 2707-10. PMID 20888750 DOI: 10.1016/j.bios.2010.09.006  0.84
2010 Cvetanovich GL, Hafler DA. Human regulatory T cells in autoimmune diseases. Current Opinion in Immunology. 22: 753-60. PMID 20869862 DOI: 10.1016/j.coi.2010.08.012  0.84
2010 Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Archives of Neurology. 67: 1055-61. PMID 20837847 DOI: 10.1001/archneurol.2010.222  0.84
2010 Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, et al. HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 75: 634-40. PMID 20713950 DOI: 10.1212/WNL.0b013e3181ed9c9c  0.84
2010 Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, et al. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Human Molecular Genetics. 19: 4286-95. PMID 20699326 DOI: 10.1093/hmg/ddq328  0.84
2010 Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL. A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. Journal of Neuroimmunology. 226: 192-3. PMID 20655601 DOI: 10.1016/j.jneuroim.2010.06.016  0.84
2010 Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, et al. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. Plos One. 5: e11296. PMID 20593013 DOI: 10.1371/journal.pone.0011296  0.84
2010 Ban M, McCauley JL, Zuvich R, Baker A, Bergamaschi L, Cox M, Kemppinen A, D'Alfonso S, Guerini FR, Lechner-Scott J, Dudbridge F, Wason J, Robertson NP, De Jager PL, Hafler DA, et al. A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. Genes and Immunity. 11: 660-4. PMID 20574445 DOI: 10.1038/gene.2010.36  0.84
2010 Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nature Reviews. Immunology. 10: 490-500. PMID 20559327 DOI: 10.1038/nri2785  0.84
2010 . IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity. 11: 397-405. PMID 20555355 DOI: 10.1038/gene.2010.28  0.84
2010 Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, et al. Variation within DNA repair pathway genes and risk of multiple sclerosis. American Journal of Epidemiology. 172: 217-24. PMID 20522537 DOI: 10.1093/aje/kwq086  0.84
2010 Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, ... ... Hafler DA, et al. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics. 42: 469-70; author reply. PMID 20502484 DOI: 10.1038/ng0610-469  0.84
2010 Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 46-54. PMID 20498357 DOI: 10.4049/jimmunol.1000356  0.84
2010 Han Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab On a Chip. 10: 1391-400. PMID 20376398 DOI: 10.1039/b926849a  0.84
2010 Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, Hauser SL, et al. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Human Molecular Genetics. 19: 2331-40. PMID 20211854 DOI: 10.1093/hmg/ddq101  0.84
2010 Jakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, ... ... Hafler DA, et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. American Journal of Human Genetics. 86: 285-91. PMID 20159113 DOI: 10.1016/j.ajhg.2010.01.017  0.84
2010 Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA, et al. Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Human Genetics. 127: 525-35. PMID 20112030 DOI: 10.1007/s00439-010-0789-4  0.84
2010 Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. Journal of Immunology (Baltimore, Md. : 1950). 184: 685-93. PMID 20018615 DOI: 10.4049/jimmunol.0902443  0.84
2010 Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Analytical Chemistry. 82: 473-7. PMID 20000848 DOI: 10.1021/ac9024363  0.84
2010 Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. The Journal of Physical Chemistry. B. 114: 585-91. PMID 19954153 DOI: 10.1021/jp908729h  0.84
2010 Severson C, Hafler DA. T-cells in multiple sclerosis. Results and Problems in Cell Differentiation. 51: 75-98. PMID 19582415 DOI: 10.1007/400_2009_12  0.84
2009 De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, ... ... Hafler DA, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. The Lancet. Neurology. 8: 1111-9. PMID 19879194 DOI: 10.1016/S1474-4422(09)70275-3  0.84
2009 Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, ... ... Hafler DA, et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proceedings of the National Academy of Sciences of the United States of America. 106: 18680-5. PMID 19846760 DOI: 10.1073/pnas.0909307106  0.84
2009 Liu DV, Maier LM, Hafler DA, Wittrup KD. Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 32: 887-94. PMID 19816193 DOI: 10.1097/CJI.0b013e3181b528da  0.84
2009 Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 4432-9. PMID 19748982 DOI: 10.4049/jimmunol.0900576  0.84
2009 McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, ... ... Hafler DA, et al. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 183: 4067-76. PMID 19687098 DOI: 10.4049/jimmunol.0801888  0.84
2009 Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European Journal of Immunology. 39: 2492-501. PMID 19676072 DOI: 10.1002/eji.200939274  0.84
2009 Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O'Connor KC. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain : a Journal of Neurology. 132: 3318-28. PMID 19638446 DOI: 10.1093/brain/awp200  0.84
2009 Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, ... ... Hafler DA, et al. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nature Genetics. 41: 931-5. PMID 19597493 DOI: 10.1038/ng.415  0.84
2009 Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP, Gilden D. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Annals of Neurology. 65: 639-49. PMID 19557869 DOI: 10.1002/ana.21641  0.84
2009 Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 945-52. PMID 19553543 DOI: 10.4049/jimmunol.0900921  0.84
2009 De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, ... ... Hafler DA, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature Genetics. 41: 776-82. PMID 19525953 DOI: 10.1038/ng.401  0.84
2009 Pyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL, Mesirov JP. Automated high-dimensional flow cytometric data analysis. Proceedings of the National Academy of Sciences of the United States of America. 106: 8519-24. PMID 19443687 DOI: 10.1073/pnas.0903028106  0.84
2009 Maier LM, Hafler DA. Autoimmunity risk alleles in costimulation pathways. Immunological Reviews. 229: 322-36. PMID 19426231 DOI: 10.1111/j.1600-065X.2009.00777.x  0.84
2009 De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, ... ... Hafler DA, et al. The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 5264-9. PMID 19237575 DOI: 10.1073/pnas.0813310106  0.84
2009 Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, ... ... Hafler DA, et al. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Human Molecular Genetics. 18: 1670-83. PMID 19221116 DOI: 10.1093/hmg/ddp073  0.84
2009 Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 113: 4240-9. PMID 19171879 DOI: 10.1182/blood-2008-10-183251  0.84
2009 Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. Journal of Immunology (Baltimore, Md. : 1950). 182: 1541-7. PMID 19155502  0.84
2009 Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, ... ... Hafler DA, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. Plos Genetics. 5: e1000322. PMID 19119414 DOI: 10.1371/journal.pgen.1000322  0.84
2009 . The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes and Immunity. 10: 11-4. PMID 18987646 DOI: 10.1038/gene.2008.83  0.84
2008 Hafler DA, Kuchroo V. TIMs: central regulators of immune responses. The Journal of Experimental Medicine. 205: 2699-701. PMID 19015312 DOI: 10.1084/jem.20082429  0.84
2008 Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 71: 917-24. PMID 18794494 DOI: 10.1212/01.wnl.0000325915.00112.61  0.84
2008 Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. Journal of Clinical Immunology. 28: 697-706. PMID 18763026 DOI: 10.1007/s10875-008-9236-x  0.84
2008 Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical Immunology (Orlando, Fla.). 129: 10-8. PMID 18675591 DOI: 10.1016/j.clim.2008.06.009  0.84
2008 Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation. 86: 54-62. PMID 18622278 DOI: 10.1097/TP.0b013e318173a5da  0.84
2008 De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O'Brien C, Freeman S, Granados S, Parker A, Roubenoff R, ... ... Hafler DA, et al. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain : a Journal of Neurology. 131: 1701-11. PMID 18567923 DOI: 10.1093/brain/awn118  0.84
2008 Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 454: 350-2. PMID 18469800 DOI: 10.1038/nature07021  0.84
2008 Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal of Neuroimmunology. 195: 140-5. PMID 18403025 DOI: 10.1016/j.jneuroim.2008.01.002  0.84
2008 Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cells and autoimmunity. European Journal of Immunology. 38: 921-4. PMID 18395861 DOI: 10.1002/eji.200738104  0.84
2008 Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. Journal of Immunology (Baltimore, Md. : 1950). 180: 4706-13. PMID 18354194  0.84
2008 Yang L, Anderson DE, Kuchroo J, Hafler DA. Lack of TIM-3 immunoregulation in multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 180: 4409-14. PMID 18354161  0.84
2008 Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. Journal of Immunology (Baltimore, Md. : 1950). 180: 2876-85. PMID 18292509  0.84
2008 De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A. Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology. 70: 1113-8. PMID 18272866 DOI: 10.1212/01.wnl.0000294325.63006.f8  0.84
2008 Maier LM, Hafler DA. The developing mosaic of autoimmune disease risk. Nature Genetics. 40: 131-2. PMID 18227869 DOI: 10.1038/ng0208-131  0.84
2008 Baecher-Allan C, Hafler DA. Response to comment on "MHC class II expression identifies functionally distinct human regulatory T cells" Journal of Immunology. 180: 3626.  0.84
2007 Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science (New York, N.Y.). 318: 1141-3. PMID 18006747 DOI: 10.1126/science.1148536  0.84
2007 Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proceedings of the National Academy of Sciences of the United States of America. 104: 18607-12. PMID 18000051 DOI: 10.1073/pnas.0706409104  0.84
2007 Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, ... ... Hafler DA, et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nature Genetics. 39: 1477-82. PMID 17982456 DOI: 10.1038/ng.2007.27  0.84
2007 Astier AL, Hafler DA. Abnormal Tr1 differentiation in multiple sclerosis Journal of Neuroimmunology. 191: 70-78. PMID 17936368 DOI: 10.1016/j.jneuroim.2007.09.018  0.84
2007 Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, et al. Risk alleles for multiple sclerosis identified by a genomewide study. The New England Journal of Medicine. 357: 851-62. PMID 17660530 DOI: 10.1056/NEJMoa073493  0.84
2007 Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L. Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature. 448: 474-9. PMID 17568699 DOI: 10.1038/nature05935  0.84
2007 De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, ... ... Hafler DA, et al. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases Genes and Immunity. 8: 387-397. PMID 17538633 DOI: 10.1038/sj.gene.6364398  0.84
2007 Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, et al. Polyspecificity of T cell and B cell receptor recognition. Seminars in Immunology. 19: 216-24. PMID 17398114 DOI: 10.1016/j.smim.2007.02.012  0.72
2007 Cai G, Hafler DA. Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes European Journal of Immunology. 37: 602-612. PMID 17304631 DOI: 10.1002/eji.200636787  0.84
2007 Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, ... ... Hafler DA, et al. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals of Neurology. 61: 228-36. PMID 17252545 DOI: 10.1002/ana.21063  0.84
2007 O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, ... ... Hafler DA, et al. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine. 13: 211-7. PMID 17237795 DOI: 10.1038/nm1488  0.72
2007 De Jager PL, Hafler DA. New therapeutic approaches for multiple sclerosis Annual Review of Medicine. 58: 417-432. PMID 17217332 DOI: 10.1146/annurev.med.58.071105.111552  0.84
2007 Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O'Connor KC. A local antigen-driven humoral response is present in the inflammatory myopathies. Journal of Immunology (Baltimore, Md. : 1950). 178: 547-56. PMID 17182595  0.72
2007 Hafler DA. Cytokines and interventional immunology Nature Reviews Immunology. 7: 423. DOI: 10.1038/nri2101  0.84
2007 O'Connor KC, Cherry SV, Hafler DA. How B cells contribute to multiple sclerosis pathology Immune Regulation and Immunotherapy in Autoimmune Disease. 66-86. DOI: 10.1007/978-0-387-36003-4_5  0.84
2007 Hafler DA, Compston A, Hauser SL. The authors reply [6] New England Journal of Medicine. 357: 2200-2201.  0.84
2006 Baecher-Allan CM, Hafler DA. The purification and functional analysis of human CD4+CD25high regulatory T cells. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 7.4B. PMID 18432975 DOI: 10.1002/0471142735.im0704bs72  0.84
2006 O'Connor KC, Roy SM, Becker CH, Hafler DA, Kantor AB. Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Disease Markers. 22: 213-25. PMID 17124343  0.72
2006 Astier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. The Journal of Clinical Investigation. 116: 3252-7. PMID 17099776 DOI: 10.1172/JCI29251  0.72
2006 de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, ... ... Hafler DA, et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature Genetics. 38: 1166-72. PMID 16998491 DOI: 10.1038/ng1885  0.72
2006 Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. Journal of Immunology (Baltimore, Md. : 1950). 177: 4196-202. PMID 16951385  0.72
2006 Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease Immunological Reviews. 212: 203-216. PMID 16903916 DOI: 10.1111/j.0105-2896.2006.00417.x  0.72
2006 Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of Experimental Medicine. 203: 1413-8. PMID 16754722 DOI: 10.1084/jem.20060210  0.72
2006 De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes and Immunity. 7: 327-34. PMID 16642031 DOI: 10.1038/sj.gene.6364303  0.72
2006 De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD. Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. European Journal of Human Genetics : Ejhg. 14: 317-21. PMID 16391555 DOI: 10.1038/sj.ejhg.5201548  0.72
2005 Wilson DB, Hafler DA, Kent SC, Chen Y, Bregoli L, Clemmings SM, Hering B, Kenyon NS, Ricordi C. Immunology: Insulin auto-antigenicity in type 1 diabetes Nature. 438: E5. PMID 16306940 DOI: 10.1038/nature04423  0.72
2005 Baecher-Allan CM, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells Clinical Immunology (Orlando, Fla.). 117: 192; discussion 193. PMID 16214081 DOI: 10.1016/j.clim.2005.02.018  0.72
2005 Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, ... ... Hafler DA, et al. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nature Genetics. 37: 1113-8. PMID 16186815 DOI: 10.1038/ng1646  0.72
2005 Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells Journal of Immunology. 175: 4458-4464. PMID 16177088  0.72
2005 O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. Journal of Immunology (Baltimore, Md. : 1950). 175: 1974-82. PMID 16034142  0.72
2005 Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clinical Immunology (Orlando, Fla.). 115: 313-22. PMID 15893699 DOI: 10.1016/j.clim.2005.02.015  0.72
2005 Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope Nature. 435: 224-228. PMID 15889096 DOI: 10.1038/nature03625  0.72
2005 Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunological Reviews. 204: 208-31. PMID 15790361 DOI: 10.1111/j.0105-2896.2005.00240.x  0.84
2005 Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, et al. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. Journal of Immunology (Baltimore, Md. : 1950). 174: 1938-46. PMID 15699121  0.84
2005 Hafler DA, De Jager PL. Applying a new generation of genetic maps to understand human inflammatory disease Nature Reviews Immunology. 5: 83-91. PMID 15630431 DOI: 10.1038/nri1532  0.84
2005 Baecher-Allan CM, Hafler DA. Letter to the editor Clinical Immunology. 117: 192. DOI: 10.1016/j.clim.2005.08.008  0.72
2005 Abbas AK, Cookson W, Foote SJ, Goldstein DB, Goodnow CC, Hafler DA, Kere J, Kuchroo VK, Rao A, Seed B, Lineberger JT, Umetsu D. Discussion Novartis Foundation Symposium. 267: 52-56.  0.84
2004 Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cellular Immunology. 230: 89-98. PMID 15598424 DOI: 10.1016/j.cellimm.2004.09.004  0.72
2004 De Jager PL, Walsh EC, Rioux JD, Hafler DA. Re: GAMES issue study: Are international genetic consortia functional? Journal of Neuroimmunology. 153: 5-6. PMID 15334748  0.72
2004 Baecher-Allan C, Hafler DA. Suppressor T cells in human diseases Journal of Experimental Medicine. 200: 273-276. PMID 15280423 DOI: 10.1084/jem.20040812  0.72
2004 Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. Journal of Immunology (Baltimore, Md. : 1950). 173: 1689-98. PMID 15265898  0.72
2004 Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, et al. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Human Molecular Genetics. 13: 1943-9. PMID 15238506 DOI: 10.1093/hmg/ddh202  0.72
2004 Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. European Journal of Immunology. 34: 1839-48. PMID 15214032 DOI: 10.1002/eji.200324044  0.72
2004 Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis Journal of Immunology. 172: 7169-7176. PMID 15153541  0.72
2004 Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 20: 563-75. PMID 15142525 DOI: 10.1016/S1074-7613(04)00110-4  0.72
2004 De Jager PL, Hafler DA. Gene expression profiling in MS: What is the clinical relevance? Lancet Neurology. 3: 269. PMID 15099539 DOI: 10.1016/S1474-4422(04)00731-8  0.72
2004 Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, ... ... Hafler DA, et al. A high-density admixture map for disease gene discovery in african americans. American Journal of Human Genetics. 74: 1001-13. PMID 15088270 DOI: 10.1086/420856  0.72
2004 Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. American Journal of Human Genetics. 74: 979-1000. PMID 15088269 DOI: 10.1086/420871  0.72
2004 Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. The Journal of Experimental Medicine. 199: 971-9. PMID 15067033 DOI: 10.1084/jem.20031579  0.72
2004 Baecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells Seminars in Immunology. 16: 89-97. PMID 15036232 DOI: 10.1016/j.smim.2003.12.005  0.72
2004 Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27 kip1 Down-regulation and bcl-xL Induction, and is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity Journal of Biological Chemistry. 279: 910-919. PMID 14573608 DOI: 10.1074/jbc.M209733200  0.72
2004 Raine CS, Oksenberg JR, Hauser SL, McFarland HF, Martin R, Weinshenker BG, Kantarci OH, Ebers GC, Sadovnik AD, De Jager PL, Walsh EC, Rioux JD, Hafler DA. Letters to the editors Journal of Neuroimmunology. 153: 1-6. DOI: 10.1016/j.jneuroim.2004.04.017  0.72
2004 Lim DG, Hafler DA. Molecular Mimicry in Multiple Sclerosis: Role of MHC-Altered Peptide Ligands (MAPL) Infection and Autoimmunity, 2nd Edition. 45-55. DOI: 10.1016/B978-044451271-0.50004-1  0.84
2003 Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA, Abbas, Bluestone, Shevach, Roncarolo. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo Novartis Foundation Symposium. 252: 67-91. PMID 14609213  0.72
2003 Walsh EC, Guschwan-McMahon S, Daly MJ, Hafler DA, Rioux JD. Genetic analysis of multiple sclerosis. Journal of Autoimmunity. 21: 111-6. PMID 12935779 DOI: 10.1016/S0896-8411(03)00094-5  0.72
2003 Lim DG, Slavik JM, Bourcier K, Smith KJ, Hafler DA. Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function Journal of Experimental Medicine. 198: 99-109. PMID 12847139 DOI: 10.1084/jem.20021796  0.72
2003 Schmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis Clinical Immunology. 106: 163-174. PMID 12706402 DOI: 10.1016/S1521-6616(03)00020-2  0.72
2003 O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. Journal of Neuroimmunology. 136: 140-8. PMID 12620653 DOI: 10.1016/S0165-5728(03)00002-X  0.72
2003 Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. Journal of Autoimmunity. 20: 71-81. PMID 12604314 DOI: 10.1016/S0896-8411(02)00106-3  0.72
2003 Buckle GJ, Höllsberg P, Hafler DA. Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin Neurology. 60: 702-705. PMID 12601116  0.72
2003 Cao D, Malmström V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis European Journal of Immunology. 33: 215-223. PMID 12594850 DOI: 10.1002/immu.200390024  0.72
2003 Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, De Andrade M, Hafler DA, Weinshenker BG. CTLA4 is associated with susceptibility to multiple sclerosis Journal of Neuroimmunology. 134: 133-141. PMID 12507781 DOI: 10.1016/S0165-5728(02)00395-8  0.72
2002 Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4+CD25+high regulatory T cell function Journal of Immunology. 169: 6210-6217. PMID 12444126  0.72
2002 Lim DG, Höllsberg P, Hafler DA. Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells Cellular Immunology. 217: 36-46. PMID 12425999 DOI: 10.1016/S0008-8749(02)00511-7  0.72
2002 Hafler DA. Degeneracy, as opposed to specificity, in immunotherapy Journal of Clinical Investigation. 109: 581-584. PMID 11877465 DOI: 10.1172/JCI200215198  0.72
2001 Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA, Hafler DA. Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset. Autoimmunity. 34: 247-64. PMID 11905851  0.72
2001 Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. Journal of Immunology (Baltimore, Md. : 1950). 167: 5669-77. PMID 11698439  0.72
2001 Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. Conserved CDR3 regions in T-cell receptor (TCR) CD8+ T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: Relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure Journal of Virology. 75: 9836-9843. PMID 11559817 DOI: 10.1128/JVI.75.20.9836-9843.2001  0.72
2001 Anderson DE, Hafler DA. Immune tolerance and the nervous system. Advances in Experimental Medicine and Biology. 490: 79-98. PMID 11505978  0.72
2001 Ohashi T, Yukitake M, Slavin A, Krieger J, Hafler DA. In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG Journal of Neuroimmunology. 118: 194-202. PMID 11498254 DOI: 10.1016/S0165-5728(01)00321-6  0.72
2001 O'Connor KC, Bar-Or A, Hafler DA. The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. Journal of Clinical Immunology. 21: 81-92. PMID 11332657 DOI: 10.1023/A:1011064007686  0.72
2001 Trollmo C, Meyer AL, Steere AC, Hafler DA, Huber BT. Molecular mimicry in lyme arthritis demonstrated at the single cell level: LFA-1αL is a partial agonist for outer surface protein A-reactive T cells Journal of Immunology. 166: 5286-5291. PMID 11290815  0.72
2001 Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Uncoupling p70s6 kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8+ T lymphocytes1 Journal of Immunology. 166: 3201-3209. PMID 11207273  0.72
2001 Gausling R, Trollmo C, Hafler DA. Decreases in interleukin-4 secretion by invariant CD4-CD8-Vα24JαQ T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis Clinical Immunology. 98: 11-17. PMID 11141321 DOI: 10.1006/clim.2000.4942  0.72
2001 Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4 + CD25 high regulatory cells in human peripheral blood Journal of Immunology. 167: 1245-1253.  0.72
2000 Duda PW, Krieger JI, Schmied MC, Balentine C, Hafler DA. Human and murine CD4 T cell reactivity to a complex antigen: Recognition of the synthetic random polypeptide glatiramer acetate Journal of Immunology. 165: 7300-7307. PMID 11120865  0.72
2000 Harrison LC, Hafler DA. Antigen-specific therapy for autoimmune disease Current Opinion in Immunology. 12: 704-711. PMID 11102776 DOI: 10.1016/S0952-7915(00)00166-7  0.72
2000 Lim DG, Bourcier KB, Freeman GJ, Hafler DA. Examination of CD8+ t cell function in humans using MHC class I tetramers: Similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope Journal of Immunology. 165: 6214-6220. PMID 11086055  0.72
2000 Kiefer R, Dangond F, Mueller M, Toyka KV, Hafler DA, Hartung HP. Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies Journal of Neurology Neurosurgery and Psychiatry. 69: 362-368. PMID 10945811 DOI: 10.1136/jnnp.69.3.362  0.72
2000 Kipp B, Bar-Or A, Gausling R, Oliveira EML, Fruhan SA, Stuart WH, Hafler DA. A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis European Journal of Immunology. 30: 2092-2100. PMID 10940899 DOI: 10.1002/1521-4141(200007)30:7<2092::AID-IMMU2092>3.0.CO;2-7  0.72
2000 Hunter SF, Hafler DA. Ubiquitous pathogens: Links between infection and autoimmunity in MS? Neurology. 55: 164-165. PMID 10908883  0.72
2000 Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, Strominger JL, Byrne MC. Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 97: 7411-6. PMID 10840051 DOI: 10.1073/pnas.120161297  0.72
2000 Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis Journal of Clinical Investigation. 105: 967-976. PMID 10749576  0.72
2000 Anderson DE, Bieganowska KD, Bar-Or A, Oliveira EM, Carreno B, Collins M, Hafler DA. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nature Medicine. 6: 211-4. PMID 10655112 DOI: 10.1038/72323  0.72
1999 Bar-Or A, Oliveira EM, Anderson DE, Hafler DA. Molecular pathogenesis of multiple sclerosis. Journal of Neuroimmunology. 100: 252-9. PMID 10695735 DOI: 10.1016/S0165-5728(99)00193-9  0.72
1999 Anderson DE, Sharpe AH, Hafler DA. The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion in Immunology. 11: 677-83. PMID 10631554 DOI: 10.1016/S0952-7915(99)00036-9  0.72
1999 Flavell RA, Hafler DA. Autoimmunity. What is the turning point? Current Opinion in Immunology. 11: 635-637. PMID 10631547 DOI: 10.1016/S0952-7915(99)00029-1  0.72
1999 Hohol MJ, Olek MJ, Orav EJ, Stazzone L, Hafler DA, Khoury SJ, Dawson DM, Weiner HL. Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease. Multiple Sclerosis (Houndmills, Basingstoke, England). 5: 403-9. PMID 10618696  0.72
1999 Kent SC, Hafler DA, Strominger JL, Wilson SB. Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. Human Immunology. 60: 1080-9. PMID 10600006 DOI: 10.1016/S0198-8859(99)00109-3  0.72
1999 Hafler DA. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis Journal of Clinical Investigation. 104: 527-529. PMID 10487765  0.72
1999 Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL, Hafler DA. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. Journal of Immunology (Baltimore, Md. : 1950). 163: 2522-9. PMID 10452989  0.72
1999 She JX, Ellis TM, Wilson SB, Wasserfall CH, Marron M, Reimsneider S, Kent SC, Hafler DA, Neuberg DS, Muir A, Strominger JL, Atkinson MA. Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 96: 8116-9. PMID 10393957 DOI: 10.1073/pnas.96.14.8116  0.72
1999 Smith D, Buckle GJ, Hafler DA, Frank DA, Höllsberg P. HTLV-I-infected T cells evade the antiproliferative action of IFN-β Virology. 257: 314-321. PMID 10329542 DOI: 10.1006/viro.1999.9679  0.72
1998 Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. Journal of Neuroimmunology. 91: 1-9. PMID 9846813  0.88
1998 Takashima H, Smith DR, Fukaura H, Khoury SJ, Hafler DA, Weiner HL. Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. Clinical Immunology and Immunopathology. 88: 28-34. PMID 9683547  0.88
1998 Scholz C, Patton KT, Anderson DE, Freeman GJ, Hafler DA. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation Journal of Immunology. 160: 1532-1538. PMID 9570577  0.72
1998 Mandelboim O, Kent S, Davis DM, Wilson SB, Okazaki T, Jackson R, Hafler D, Strominger JL. Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 3798-803. PMID 9520447 DOI: 10.1073/pnas.95.7.3798  0.72
1998 Milner J, Kent S, Wilson S, Strominger J, Hafler D. Phenotypic characterization of invariant Vα24JαQ NK T cells from twins discordant for IDDM Faseb Journal. 12: A1091.  0.72
1997 Hafler DA, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Fukaura H. Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Annals of the New York Academy of Sciences. 835: 120-31. PMID 9616767 DOI: 10.1111/j.1749-6632.1997.tb48623.x  0.72
1997 Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P, Hafler DA. Autoantigen Recognition by Human CD8 T Cell Clones: Enhanced Agonist Response Induced by Altered Peptide Ligands Journal of Immunology. 159: 4943-4951. PMID 9366420  0.72
1997 Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a Hypoglycosylated Form of CD86 (B7-2) on Human T Cells with Altered Binding Properties to CD28 and CTLA-4 Journal of Immunology. 159: 4799-4805. PMID 9366404  0.72
1997 Smith DR, Balashov KE, Hafler DA, Khoury SJ, Weiner HL. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Annals of Neurology. 42: 313-8. PMID 9307252 DOI: 10.1002/ana.410420307  0.72
1997 Ausubel LJ, Krieger JI, Hafler DA. Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. Journal of Immunology (Baltimore, Md. : 1950). 159: 2502-12. PMID 9278344  0.72
1997 Anderson DE, Ausubel LJ, Krieger J, Höllsberg P, Freeman GJ, Hafler DA. Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. Journal of Immunology (Baltimore, Md. : 1950). 159: 1669-75. PMID 9257827  0.72
1997 Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Annals of the New York Academy of Sciences. 815: 412-22. PMID 9186687 DOI: 10.1111/j.1749-6632.1997.tb52092.x  0.72
1997 Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS, Whitcup SM. Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. American Journal of Ophthalmology. 123: 583-92. PMID 9152063  0.88
1997 Richardson JH, Höllsberg P, Windhagen A, Child LA, Hafler DA, Lever AML. Variable immortalizing potential and frequent virus latency in blood- derived T-cell clones infected with human T-cell leukemia virus type I Blood. 89: 3303-3314. PMID 9129036  0.72
1997 Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 Expressed by T Cells Does Not Induce CD28-Mediated Costimulatory Activity but Retains CTLA4 Binding: Implications for Induction of Antitumor Immunity to T Cell Tumors Journal of Immunology. 158: 2025-2034. PMID 9036945  0.72
1997 Balashov KE, Smith DR, Khoury SJ, Hafler DA, Weiner HL. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proceedings of the National Academy of Sciences of the United States of America. 94: 599-603. PMID 9012830  0.88
1996 Höllsberg P, Batra V, Dressel A, Hafler DA. Induction of Anergy in CD8 T Cells by B Cell Presentation of Antigen Journal of Immunology. 157: 5269-5276. PMID 8955172  0.72
1996 Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA. Role of Th1 and Th2 cells in neurologic disorders. Chemical Immunology. 63: 171-86. PMID 8934837  0.88
1996 Scholz C, Freeman GJ, Greenfield EA, Hafler DA, Höllsberg P. Activation of Human T Cell Lymphotropic Virus Type I-Infected T Cells Is Independent of B7 Costimulation Journal of Immunology. 157: 2932-2938. PMID 8816399  0.72
1996 Rothenberg ME, Weber WE, Longtine JA, Hafler DA. Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clinical Immunology and Immunopathology. 80: 266-72. PMID 8811046  0.72
1996 Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. The Journal of Clinical Investigation. 98: 70-7. PMID 8690806 DOI: 10.1172/JCI118779  0.88
1996 Matsui M, Hafler DA, Weiner HL. Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency. Annals of the New York Academy of Sciences. 778: 398-404. PMID 8611003  0.72
1996 Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Annals of the New York Academy of Sciences. 778: 251-7. PMID 8610978  0.88
1996 Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA, Weiner HL. Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Annals of the New York Academy of Sciences. 778: 243-50. PMID 8610977 DOI: 10.1111/j.1749-6632.1996.tb21132.x  0.72
1996 Pohl-Koppe A, Balachov K, Logigian E, Steere AC, Hafler DA. The immune response to borrelia burgdorferi (BB) is characterized by T-cell lines secreting both IFNγ and IL-10 in patients with lyme disease Faseb Journal. 10: A1184.  0.72
1996 Dressel A, Seite A, Gausling R, Weber W, Liu L, Hafler DA. Proteolipid protein (PLP) reactive HLA-A2 restricted CD8+ T-cell clones Faseb Journal. 10: A1315.  0.72
1996 Bieganowska K, Modabber Y, Messersmith W, Slovik E, Hafler DA. Direct analysis from peripheral blood of myelin basic protein (mbp) reactive T cells Faseb Journal. 10: A1352.  0.72
1995 Hafler DA, Weiner HL. Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. Chemical Immunology. 60: 126-49. PMID 7857525  0.88
1995 Hafler DA, Weiner HL. Antigen specific therapies for the treatment of autoimmune diseases. Agents and Actions. Supplements. 47: 59-77. PMID 7785504  0.88
1995 Balashov KE, Khoury SJ, Hafler DA, Weiner HL. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. The Journal of Clinical Investigation. 95: 2711-9. PMID 7769110 DOI: 10.1172/JCI117973  0.88
1995 Weiner HL, Hohol MJ, Khoury SJ, Dawson DM, Hafler DA. Therapy for multiple sclerosis. Neurologic Clinics. 13: 173-96. PMID 7739502  0.84
1995 Hafler DA, Weiner HL. Immunologic mechanisms and therapy in multiple sclerosis. Immunological Reviews. 144: 75-107. PMID 7590822  0.88
1995 Wucherpfennig KW, Hafler DA, Strominger JL. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 92: 8896-900. PMID 7568039 DOI: 10.1073/pnas.92.19.8896  0.84
1995 Wucherpfennig KW, Hafler DA. A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Annals of the New York Academy of Sciences. 756: 241-58. PMID 7544075 DOI: 10.1111/j.1749-6632.1995.tb44522.x  0.84
1995 Hafler DA, Weiner HL. Antigen-specific therapies for the treatment of autoimmune diseases. Springer Seminars in Immunopathology. 17: 61-76. PMID 7482227  0.88
1994 Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. The Journal of Experimental Medicine. 179: 1659-64. PMID 8163944  0.72
1994 Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annual Review of Immunology. 12: 809-37. PMID 8011298 DOI: 10.1146/annurev.iy.12.040194.004113  0.88
1994 Chung S, Wucherpfennig KW, Friedman SM, Hafler DA, Strominger JL. Functional three-domain single-chain T-cell receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 12654-8. PMID 7809095 DOI: 10.1073/pnas.91.26.12654  0.84
1994 Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (New York, N.Y.). 265: 1237-40. PMID 7520605  0.88
1994 Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. Journal of Immunology (Baltimore, Md. : 1950). 152: 5581-92. PMID 7514641  0.72
1994 Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. The Journal of Experimental Medicine. 179: 973-84. PMID 7509366  0.72
1994 Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. The Journal of Experimental Medicine. 179: 279-90. PMID 7505801 DOI: 10.1084/jem.179.1.279  0.84
1993 Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology. 43: 910-8. PMID 8388090  0.88
1993 Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL. Effects of oral administration of type II collagen on rheumatoid arthritis. Science (New York, N.Y.). 261: 1727-30. PMID 8378772  0.72
1993 Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. The Journal of Experimental Medicine. 177: 425-32. PMID 8093893  0.72
1993 Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clinical and Experimental Rheumatology. 11: S39-40. PMID 7686832  0.72
1993 Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL, Hafler DA. Biological activity of recombinant human myelin basic protein. Journal of Neuroimmunology. 44: 157-62. PMID 7685037 DOI: 10.1016/0165-5728(93)90037-Y  0.84
1993 Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science (New York, N.Y.). 259: 1321-4. PMID 7680493  0.88
1992 Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proceedings of the National Academy of Sciences of the United States of America. 89: 2110-4. PMID 1549569  0.84
1992 Hafler DA, Cohen I, Benjamin DS, Weiner HL. T cell vaccination in multiple sclerosis: a preliminary report. Clinical Immunology and Immunopathology. 62: 307-13. PMID 1541056  0.88
1992 Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America. 89: 4588-92. PMID 1374907  0.84
1992 Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA. Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. Journal of Immunology (Baltimore, Md. : 1950). 148: 3256-63. PMID 1374452  0.84
1992 Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. The Journal of Experimental Medicine. 175: 993-1002. PMID 1348083  0.84
1992 Zhang J, Weiner HL, Hafler DA. Autoreactive T cells in multiple sclerosis. International Reviews of Immunology. 9: 183-201. PMID 1285060 DOI: 10.3109/08830189209061790  0.88
1991 Miller A, Hafler DA, Weiner HL. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2560-6. PMID 1868980  0.88
1991 Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA. Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Annals of Neurology. 29: 33-40. PMID 1847614 DOI: 10.1002/ana.410290109  0.72
1991 Miller A, Hafler DA, Weiner HL. Immunotherapy in autoimmune diseases. Current Opinion in Immunology. 3: 936-40. PMID 1793539  0.88
1991 Hafler DA, Matsui M, Wucherpfennig KW, Ota K, Weiner HL. The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Annals of the New York Academy of Sciences. 636: 251-65. PMID 1724362  0.72
1991 Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunology Today. 12: 277-82. PMID 1716903 DOI: 10.1016/0167-5699(91)90126-E  0.84
1991 Brod SA, al-Sabbagh A, Sobel RA, Hafler DA, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Annals of Neurology. 29: 615-22. PMID 1716432 DOI: 10.1002/ana.410290608  0.72
1991 Hafler DA, Orav J, Gertz R, Stazzone L, Weiner HL. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. Journal of Neuroimmunology. 32: 149-58. PMID 1672870  0.88
1991 Hafler DA, Chofflon M, Kurt-Jones E, Weiner HL. Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clinical Immunology and Immunopathology. 58: 115-25. PMID 1670583  0.88
1990 Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science (New York, N.Y.). 248: 1016-9. PMID 1693015  0.84
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