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Takatoshi Hikida, M.D., Ph.D. - Publications

Affiliations: 
Graduate School of Medicine Kyoto University, Kyōto-shi, Kyōto-fu, Japan 
Area:
Pathophysiology of schizophrenia, regulatory mechanism of basal ganglia circuit
Website:
http://kyouindb.iimc.kyoto-u.ac.jp/e/gR5uK
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Nomiya H, Sakurai K, Miyamoto Y, Oka M, Yoneda Y, Hikida T, Yamada M. A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene-environment interactions. Scientific Reports. 14: 3376. PMID 38336912 DOI: 10.1038/s41598-024-53237-3  0.367
2023 Macpherson T, Niwa M, Morishita H, Hikida T. Editorial: Circuit, molecular, and developmental mechanisms in decision-making behavior. Frontiers in Neuroscience. 17: 1192237. PMID 37179551 DOI: 10.3389/fnins.2023.1192237  0.657
2023 Nishioka T, Attachaipanich S, Hamaguchi K, Lazarus M, de Kerchove d'Exaerde A, Macpherson T, Hikida T. Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice. Nature Communications. 14: 2284. PMID 37085502 DOI: 10.1038/s41467-023-38025-3  0.744
2022 Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim SH, Zoubovsky S, Hirota-Tsuyada Y, Zala D, Bruyere J, Katz BM, Huang B, Flores R, Narayan S, Hou Z, Economides AN, ... Hikida T, et al. Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. Molecular Psychiatry. PMID 35165396 DOI: 10.1038/s41380-021-01389-3  0.779
2021 Sakurai K, Itou T, Morita M, Kasahara E, Moriyama T, Macpherson T, Ozawa T, Miyamoto Y, Yoneda Y, Sekiyama A, Oka M, Hikida T. Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice. Plos One. 16: e0258364. PMID 34767585 DOI: 10.1371/journal.pone.0258364  0.327
2020 Nishioka T, Hamaguchi K, Yawata S, Hikida T, Watanabe D. Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in Mice. Frontiers in Systems Neuroscience. 14: 38. PMID 32714157 DOI: 10.3389/Fnsys.2020.00038  0.736
2020 Anan M, Higa R, Shikano K, Shide M, Soda A, Carrasco Apolinario ME, Mori K, Shin T, Miyazato M, Mimata H, Hikida T, Hanada T, Nakao K, Kangawa K, Hanada R. Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system. Heliyon. 6: e03947. PMID 32462086 DOI: 10.1016/J.Heliyon.2020.E03947  0.35
2020 Saito N, Tainaka K, Macpherson T, Hikida T, Yamaguchi S, Sasaoka T. Neurotransmission through dopamine D1 receptor is required for aversive memory formation and Arc activation in the cerebral cortex. Neuroscience Research. PMID 32380131 DOI: 10.1016/J.Neures.2020.04.006  0.397
2020 Hikida T, Yao S, Macpherson T, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A. Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex. Scientific Reports. 10: 1838. PMID 32020036 DOI: 10.1038/S41598-020-58711-2  0.549
2019 Shioda N, Imai Y, Yabuki Y, Sugimoto W, Yamaguchi K, Wang Y, Hikida T, Sasaoka T, Mieda M, Fukunaga K. Dopamine D Receptor Deficiency Causes Stress Vulnerability through 5-HT Receptor Dysfunction in Serotonergic Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31371425 DOI: 10.1523/Jneurosci.0079-19.2019  0.412
2019 Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M. Opposing Roles of Dopamine Receptor D1- and D2-Expressing Neurons in the Anteromedial Olfactory Tubercle in Acquisition of Place Preference in Mice. Frontiers in Behavioral Neuroscience. 13: 50. PMID 30930757 DOI: 10.3389/Fnbeh.2019.00050  0.417
2019 Hikida T, Morita M, Kuroiwa M, Macpherson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience Research. PMID 30831136 DOI: 10.1016/J.Neures.2019.02.007  0.71
2019 Macpherson T, Mizoguchi H, Yamanaka A, Hikida T. Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. Neurochemistry International. PMID 30797970 DOI: 10.1016/J.Neuint.2019.02.011  0.338
2019 Macpherson T, Hikida T. The role of basal ganglia neurocircuitry in the pathology of psychiatric disorders. Psychiatry and Clinical Neurosciences. PMID 30734985 DOI: 10.1111/Pcn.12830  0.328
2018 Hikida T. [Homeostatic regulation of basal ganglia circuit for flexible behavior]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 152: 295-298. PMID 30531100 DOI: 10.1254/Fpj.152.295  0.422
2018 Macpherson T, Hikida T. Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice. Frontiers in Neuroscience. 12: 418. PMID 29977188 DOI: 10.3389/Fnins.2018.00418  0.393
2018 Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, et al. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human Molecular Genetics. PMID 29893844 DOI: 10.1093/Hmg/Ddy219  0.774
2018 Sumitomo A, Saka A, Ueta K, Horike K, Hirai K, Gamo NJ, Hikida T, Nakayama KI, Sawa A, Sakurai T, Tomoda T. Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in -Deficient Mice. Molecular Neuropsychiatry. 3: 223-233. PMID 29888233 DOI: 10.1159/000488081  0.77
2017 Miyajima M, Zhang B, Sugiura Y, Sonomura K, Guerrini MM, Tsutsui Y, Maruya M, Vogelzang A, Chamoto K, Honda K, Hikida T, Ito S, Qin H, Sanuki R, Suzuki K, et al. Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior. Nature Immunology. PMID 29058703 DOI: 10.1038/Ni.3867  0.301
2017 Tomoda T, Hikida T, Sakurai T. Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28664299 DOI: 10.1007/S13311-017-0556-5  0.407
2017 Shimizu Y, Son C, Aotani D, Nomura H, Hikida T, Hosoda K, Nakao K. Role of Leptin in Conditioned Place Preference to High-Fat Diet in Leptin-Deficient ob/ob Mice. Neuroscience Letters. PMID 28093305 DOI: 10.1016/J.Neulet.2017.01.033  0.345
2016 Sumitomo A, Ueta K, Mauchi S, Hirai K, Horike K, Hikida T, Sakurai T, Sawa A, Tomoda T. Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits. Neuroscience Research. PMID 28017600 DOI: 10.1016/J.Neures.2016.12.004  0.514
2016 Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K. Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. Molecular Psychiatry. PMID 27922607 DOI: 10.1038/Mp.2016.200  0.398
2016 Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T. Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning. Molecular Neuropsychiatry. 2: 124-132. PMID 27867937 DOI: 10.1159/000447970  0.691
2016 Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A. Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1. Neuroscience Research. PMID 27354230 DOI: 10.1016/J.Neures.2016.06.006  0.743
2016 Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T. Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learning & Memory (Cold Spring Harbor, N.Y.). 23: 359-64. PMID 27317196 DOI: 10.1101/Lm.042507.116  0.547
2016 Hikida T, Morita M, Macpherson T. Neural mechanism of the nucleus accumbens circuit in reward and aversive learning. Neuroscience Research. PMID 26827817 DOI: 10.1016/J.Neures.2016.01.004  0.376
2015 Hayashi Y, Sawa A, Hikida T. Impaired hippocampal activity at the goal zone on the place preference task in a DISC1 mouse model. Neuroscience Research. PMID 26497623 DOI: 10.1016/J.Neures.2015.10.005  0.557
2015 Sakurai T, Gamo NJ, Hikida T, Kim SH, Murai T, Tomoda T, Sawa A. Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments. Progress in Neurobiology. PMID 26408506 DOI: 10.1016/J.Pneurobio.2015.09.010  0.774
2015 Yamaguchi T, Goto A, Nakahara I, Yawata S, Hikida T, Matsuda M, Funabiki K, Nakanishi S. Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning. Proceedings of the National Academy of Sciences of the United States of America. 112: 11383-8. PMID 26305972 DOI: 10.1073/Pnas.1514731112  0.375
2015 Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. The Journal of Biological Chemistry. 290: 14493-503. PMID 25882840 DOI: 10.1074/Jbc.M114.635607  0.732
2014 Macpherson T, Morita M, Hikida T. Striatal direct and indirect pathways control decision-making behavior. Frontiers in Psychology. 5: 1301. PMID 25429278 DOI: 10.3389/Fpsyg.2014.01301  0.365
2014 Nakanishi S, Hikida T, Yawata S. Distinct dopaminergic control of the direct and indirect pathways in reward-based and avoidance learning behaviors. Neuroscience. 282: 49-59. PMID 24769227 DOI: 10.1016/J.Neuroscience.2014.04.026  0.336
2013 Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A. Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7583-94. PMID 23616563 DOI: 10.1523/Jneurosci.4932-12.2013  0.36
2013 Yamaguchi T, Danjo T, Pastan I, Hikida T, Nakanishi S. Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear. Neuron. 78: 537-44. PMID 23602500 DOI: 10.1016/J.Neuron.2013.02.035  0.331
2013 Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (New York, N.Y.). 339: 335-9. PMID 23329051 DOI: 10.1126/Science.1226931  0.726
2013 Hikida T, Yawata S, Yamaguchi T, Danjo T, Sasaoka T, Wang Y, Nakanishi S. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 342-7. PMID 23248274 DOI: 10.1073/Pnas.1220358110  0.336
2012 Hikida T, Gamo NJ, Sawa A. DISC1 as a therapeutic target for mental illnesses. Expert Opinion On Therapeutic Targets. 16: 1151-60. PMID 23130881 DOI: 10.1517/14728222.2012.719879  0.771
2012 Yawata S, Yamaguchi T, Danjo T, Hikida T, Nakanishi S. Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. 109: 12764-9. PMID 22802650 DOI: 10.1073/Pnas.1210797109  0.347
2011 Kimura K, Hikida T, Yawata S, Yamaguchi T, Nakanishi S. Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses. Proceedings of the National Academy of Sciences of the United States of America. 108: 9981-6. PMID 21628570 DOI: 10.1073/Pnas.1107592108  0.324
2010 Hikida T, Kimura K, Wada N, Funabiki K, Nakanishi S. Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior. Neuron. 66: 896-907. PMID 20620875 DOI: 10.1016/J.Neuron.2010.05.011  0.322
2010 Schretlen DJ, Vannorsdall TD, Winicki JM, Mushtaq Y, Hikida T, Sawa A, Yolken RH, Dickerson FB, Cascella NG. Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. Schizophrenia Research. 118: 224-31. PMID 20153952 DOI: 10.1016/J.Schres.2010.01.008  0.505
2008 Hikida T, Mustafa AK, Maeda K, Fujii K, Barrow RK, Saleh M, Huganir RL, Snyder SH, Hashimoto K, Sawa A. Modulation of D-serine levels in brains of mice lacking PICK1. Biological Psychiatry. 63: 997-1000. PMID 18191108 DOI: 10.1016/J.Biopsych.2007.09.025  0.598
2007 Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences of the United States of America. 104: 14501-6. PMID 17675407 DOI: 10.1073/Pnas.0704774104  0.745
2007 Hikida T, Jaaro-Peled H, Tankou S, Morita M, Pletnikov M, Kida S, Mori S, Sawa A. Production and analyses of mutant DISC1 transgenic mice: An animal model of schizophrenia Neuroscience Research. 58: S20. DOI: 10.1016/J.Neures.2007.06.117  0.76
2006 Fujii K, Maeda K, Hikida T, Mustafa AK, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir RL, Ujike H, Snyder SH, Sawa A. Serine racemase binds to PICK1: potential relevance to schizophrenia. Molecular Psychiatry. 11: 150-7. PMID 16314870 DOI: 10.1038/Sj.Mp.4001776  0.654
2004 Kitano T, Matsumura S, Seki T, Hikida T, Sakimura K, Nagano T, Mishina M, Nakanishi S, Ito S. Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity. Neurochemistry International. 44: 83-90. PMID 12971910 DOI: 10.1016/S0197-0186(03)00124-4  0.353
2003 Kitabatake Y, Hikida T, Watanabe D, Pastan I, Nakanishi S. Impairment of reward-related learning by cholinergic cell ablation in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 100: 7965-70. PMID 12802017 DOI: 10.1073/Pnas.1032899100  0.507
2003 Hikida T, Kitabatake Y, Pastan I, Nakanishi S. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. 100: 6169-73. PMID 12721372 DOI: 10.1073/Pnas.0631749100  0.319
2001 Hikida T, Kaneko S, Isobe T, Kitabatake Y, Watanabe D, Pastan I, Nakanishi S. Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. 98: 13351-4. PMID 11606786 DOI: 10.1073/Pnas.231488998  0.482
2000 Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S. Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science (New York, N.Y.). 289: 633-7. PMID 10915629 DOI: 10.1126/Science.289.5479.633  0.541
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