Takatoshi Hikida, M.D., Ph.D. - Publications

Graduate School of Medicine Kyoto University, Kyōto-shi, Kyōto-fu, Japan 
Pathophysiology of schizophrenia, regulatory mechanism of basal ganglia circuit

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim SH, Zoubovsky S, Hirota-Tsuyada Y, Zala D, Bruyere J, Katz BM, Huang B, Flores R, Narayan S, Hou Z, Economides AN, ... Hikida T, et al. Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. Molecular Psychiatry. PMID 35165396 DOI: 10.1038/s41380-021-01389-3  0.777
2021 Sakurai K, Itou T, Morita M, Kasahara E, Moriyama T, Macpherson T, Ozawa T, Miyamoto Y, Yoneda Y, Sekiyama A, Oka M, Hikida T. Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice. Plos One. 16: e0258364. PMID 34767585 DOI: 10.1371/journal.pone.0258364  0.345
2020 Nishioka T, Hamaguchi K, Yawata S, Hikida T, Watanabe D. Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in Mice. Frontiers in Systems Neuroscience. 14: 38. PMID 32714157 DOI: 10.3389/Fnsys.2020.00038  0.359
2020 Saito N, Tainaka K, Macpherson T, Hikida T, Yamaguchi S, Sasaoka T. Neurotransmission through dopamine D1 receptor is required for aversive memory formation and Arc activation in the cerebral cortex. Neuroscience Research. PMID 32380131 DOI: 10.1016/J.Neures.2020.04.006  0.389
2020 Hikida T, Yao S, Macpherson T, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A. Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex. Scientific Reports. 10: 1838. PMID 32020036 DOI: 10.1038/S41598-020-58711-2  0.528
2019 Shioda N, Imai Y, Yabuki Y, Sugimoto W, Yamaguchi K, Wang Y, Hikida T, Sasaoka T, Mieda M, Fukunaga K. Dopamine D Receptor Deficiency Causes Stress Vulnerability through 5-HT Receptor Dysfunction in Serotonergic Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31371425 DOI: 10.1523/Jneurosci.0079-19.2019  0.419
2019 Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M. Opposing Roles of Dopamine Receptor D1- and D2-Expressing Neurons in the Anteromedial Olfactory Tubercle in Acquisition of Place Preference in Mice. Frontiers in Behavioral Neuroscience. 13: 50. PMID 30930757 DOI: 10.3389/Fnbeh.2019.00050  0.383
2019 Hikida T, Morita M, Kuroiwa M, Macpherson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience Research. PMID 30831136 DOI: 10.1016/J.Neures.2019.02.007  0.71
2019 Macpherson T, Mizoguchi H, Yamanaka A, Hikida T. Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. Neurochemistry International. PMID 30797970 DOI: 10.1016/J.Neuint.2019.02.011  0.318
2019 Macpherson T, Hikida T. The role of basal ganglia neurocircuitry in the pathology of psychiatric disorders. Psychiatry and Clinical Neurosciences. PMID 30734985 DOI: 10.1111/Pcn.12830  0.355
2018 Macpherson T, Hikida T. Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice. Frontiers in Neuroscience. 12: 418. PMID 29977188 DOI: 10.3389/Fnins.2018.00418  0.358
2018 Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, et al. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human Molecular Genetics. PMID 29893844 DOI: 10.1093/Hmg/Ddy219  0.769
2018 Sumitomo A, Saka A, Ueta K, Horike K, Hirai K, Gamo NJ, Hikida T, Nakayama KI, Sawa A, Sakurai T, Tomoda T. Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in -Deficient Mice. Molecular Neuropsychiatry. 3: 223-233. PMID 29888233 DOI: 10.1159/000488081  0.768
2017 Tomoda T, Hikida T, Sakurai T. Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28664299 DOI: 10.1007/S13311-017-0556-5  0.432
2016 Sumitomo A, Ueta K, Mauchi S, Hirai K, Horike K, Hikida T, Sakurai T, Sawa A, Tomoda T. Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits. Neuroscience Research. PMID 28017600 DOI: 10.1016/J.Neures.2016.12.004  0.515
2016 Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K. Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. Molecular Psychiatry. PMID 27922607 DOI: 10.1038/Mp.2016.200  0.381
2016 Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T. Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning. Molecular Neuropsychiatry. 2: 124-132. PMID 27867937 DOI: 10.1159/000447970  0.689
2016 Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A. Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1. Neuroscience Research. PMID 27354230 DOI: 10.1016/J.Neures.2016.06.006  0.744
2016 Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T. Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learning & Memory (Cold Spring Harbor, N.Y.). 23: 359-64. PMID 27317196 DOI: 10.1101/Lm.042507.116  0.512
2016 Hikida T, Morita M, Macpherson T. Neural mechanism of the nucleus accumbens circuit in reward and aversive learning. Neuroscience Research. PMID 26827817 DOI: 10.1016/J.Neures.2016.01.004  0.337
2015 Hayashi Y, Sawa A, Hikida T. Impaired hippocampal activity at the goal zone on the place preference task in a DISC1 mouse model. Neuroscience Research. PMID 26497623 DOI: 10.1016/J.Neures.2015.10.005  0.565
2015 Sakurai T, Gamo NJ, Hikida T, Kim SH, Murai T, Tomoda T, Sawa A. Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments. Progress in Neurobiology. PMID 26408506 DOI: 10.1016/J.Pneurobio.2015.09.010  0.766
2015 Yamaguchi T, Goto A, Nakahara I, Yawata S, Hikida T, Matsuda M, Funabiki K, Nakanishi S. Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning. Proceedings of the National Academy of Sciences of the United States of America. 112: 11383-8. PMID 26305972 DOI: 10.1073/Pnas.1514731112  0.358
2015 Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. The Journal of Biological Chemistry. 290: 14493-503. PMID 25882840 DOI: 10.1074/Jbc.M114.635607  0.731
2014 Macpherson T, Morita M, Hikida T. Striatal direct and indirect pathways control decision-making behavior. Frontiers in Psychology. 5: 1301. PMID 25429278 DOI: 10.3389/Fpsyg.2014.01301  0.34
2014 Nakanishi S, Hikida T, Yawata S. Distinct dopaminergic control of the direct and indirect pathways in reward-based and avoidance learning behaviors. Neuroscience. 282: 49-59. PMID 24769227 DOI: 10.1016/J.Neuroscience.2014.04.026  0.307
2013 Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A. Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7583-94. PMID 23616563 DOI: 10.1523/Jneurosci.4932-12.2013  0.34
2013 Yamaguchi T, Danjo T, Pastan I, Hikida T, Nakanishi S. Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear. Neuron. 78: 537-44. PMID 23602500 DOI: 10.1016/J.Neuron.2013.02.035  0.312
2013 Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (New York, N.Y.). 339: 335-9. PMID 23329051 DOI: 10.1126/Science.1226931  0.697
2013 Hikida T, Yawata S, Yamaguchi T, Danjo T, Sasaoka T, Wang Y, Nakanishi S. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 342-7. PMID 23248274 DOI: 10.1073/Pnas.1220358110  0.31
2012 Hikida T, Gamo NJ, Sawa A. DISC1 as a therapeutic target for mental illnesses. Expert Opinion On Therapeutic Targets. 16: 1151-60. PMID 23130881 DOI: 10.1517/14728222.2012.719879  0.775
2012 Yawata S, Yamaguchi T, Danjo T, Hikida T, Nakanishi S. Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. 109: 12764-9. PMID 22802650 DOI: 10.1073/Pnas.1210797109  0.326
2011 Kimura K, Hikida T, Yawata S, Yamaguchi T, Nakanishi S. Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses. Proceedings of the National Academy of Sciences of the United States of America. 108: 9981-6. PMID 21628570 DOI: 10.1073/Pnas.1107592108  0.312
2010 Schretlen DJ, Vannorsdall TD, Winicki JM, Mushtaq Y, Hikida T, Sawa A, Yolken RH, Dickerson FB, Cascella NG. Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. Schizophrenia Research. 118: 224-31. PMID 20153952 DOI: 10.1016/J.Schres.2010.01.008  0.516
2008 Hikida T, Mustafa AK, Maeda K, Fujii K, Barrow RK, Saleh M, Huganir RL, Snyder SH, Hashimoto K, Sawa A. Modulation of D-serine levels in brains of mice lacking PICK1. Biological Psychiatry. 63: 997-1000. PMID 18191108 DOI: 10.1016/J.Biopsych.2007.09.025  0.602
2007 Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences of the United States of America. 104: 14501-6. PMID 17675407 DOI: 10.1073/Pnas.0704774104  0.728
2007 Hikida T, Jaaro-Peled H, Tankou S, Morita M, Pletnikov M, Kida S, Mori S, Sawa A. Production and analyses of mutant DISC1 transgenic mice: An animal model of schizophrenia Neuroscience Research. 58: S20. DOI: 10.1016/J.Neures.2007.06.117  0.754
2006 Fujii K, Maeda K, Hikida T, Mustafa AK, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir RL, Ujike H, Snyder SH, Sawa A. Serine racemase binds to PICK1: potential relevance to schizophrenia. Molecular Psychiatry. 11: 150-7. PMID 16314870 DOI: 10.1038/Sj.Mp.4001776  0.654
2004 Kitano T, Matsumura S, Seki T, Hikida T, Sakimura K, Nagano T, Mishina M, Nakanishi S, Ito S. Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity. Neurochemistry International. 44: 83-90. PMID 12971910 DOI: 10.1016/S0197-0186(03)00124-4  0.363
2003 Kitabatake Y, Hikida T, Watanabe D, Pastan I, Nakanishi S. Impairment of reward-related learning by cholinergic cell ablation in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 100: 7965-70. PMID 12802017 DOI: 10.1073/Pnas.1032899100  0.305
2000 Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S. Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science (New York, N.Y.). 289: 633-7. PMID 10915629 DOI: 10.1126/Science.289.5479.633  0.351
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