Koko Ishizuka, M.D., Ph.D. - Publications

Johns Hopkins University, Baltimore, MD 
Neuropsychiatric diseases and brain development

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yang K, Kondo MA, Jaaro-Peled H, Cash-Padgett T, Kano SI, Ishizuka K, Pevsner J, Tomoda T, Sawa A, Niwa M. The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood. Schizophrenia Research. PMID 31204062 DOI: 10.1016/j.schres.2019.05.032  0.96
2019 John JP, Thirunavukkarasu P, Ishizuka K, Parekh P, Sawa A. An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration. Npj Systems Biology and Applications. 5: 17. PMID 31098296 DOI: 10.1038/s41540-019-0094-3  0.96
2019 Tharakan R, Kreimer S, Ubaida-Mohien C, Lavoie J, Olexiouk V, Menschaert G, Ingolia NT, Cole RN, Ishizuka K, Sawa A, Nucifora LG. A methodology for discovering novel brain-relevant peptides: Combination of ribosome profiling and peptidomics. Neuroscience Research. PMID 30862443 DOI: 10.1016/j.neures.2019.02.006  0.96
2018 Kano SI, Hodgkinson CA, Jones-Brando L, Eastwood S, Ishizuka K, Niwa M, Choi EY, Chang DJ, Chen Y, Velivela SD, Leister F, Wood J, Chowdari K, Ducci F, Caycedo DA, et al. Host-parasite interaction associated with major mental illness. Molecular Psychiatry. PMID 30127472 DOI: 10.1038/s41380-018-0217-z  0.96
2018 Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, ... ... Ishizuka K, et al. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human Molecular Genetics. PMID 29893844 DOI: 10.1093/hmg/ddy219  0.96
2018 Lema YY, Gamo NJ, Yang K, Ishizuka K. Trait and state biomarkers for psychiatric disorders: Importance of infrastructure to bridge the gap between basic and clinical research and industry. Psychiatry and Clinical Neurosciences. PMID 29687938 DOI: 10.1111/pcn.12669  0.6
2018 McLean CK, Narayan S, Lin SY, Rai N, Chung Y, Hipolito MS, Cascella NG, Nurnberger JI, Ishizuka K, Sawa AS, Nwulia EA. Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder. Translational Psychiatry. 8: 81. PMID 29666369 DOI: 10.1038/s41398-018-0126-6  0.68
2018 Srivastava R, Faust T, Ramos A, Ishizuka K, Sawa A. Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models. Biological Psychiatry. PMID 29486891 DOI: 10.1016/j.biopsych.2018.01.007  0.96
2017 Park SJ, Lee SB, Suh Y, Kim SJ, Lee N, Hong JH, Park C, Woo Y, Ishizuka K, Kim JH, Berggren PO, Sawa A, Park SK. DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca2+ Transfer through the MAM. Cell Reports. 21: 2748-2759. PMID 29212023 DOI: 10.1016/j.celrep.2017.11.043  0.96
2017 Sagata N, Kato TA, Kano SI, Ohgidani M, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Wilson AM, Ishizuka K, Kato S, Nakahara T, Nakahara-Kido M, Setoyama D, Sakai Y, et al. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study. Scientific Reports. 7: 13905. PMID 29066822 DOI: 10.1038/s41598-017-14440-7  0.96
2017 Kamath V, Lasutschinkow P, Ishizuka K, Sawa A. Olfactory Functioning in First-Episode Psychosis. Schizophrenia Bulletin. PMID 28981913 DOI: 10.1093/schbul/sbx107  0.96
2017 Shao L, Lu B, Wen Z, Teng S, Wang L, Zhao Y, Wang L, Ishizuka K, Xu X, Sawa A, Song H, Ming G, Zhong Y. Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Human Molecular Genetics. PMID 28472294 DOI: 10.1093/hmg/ddx147  0.96
2017 Lavoie J, Sawa A, Ishizuka K. Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research. Current Opinion in Psychiatry. PMID 28333692 DOI: 10.1097/YCO.0000000000000327  0.96
2017 Tanaka M, Ishizuka K, Nekooki-Machida Y, Endo R, Takashima N, Sasaki H, Komi Y, Gathercole A, Huston E, Ishii K, Hui KK, Kurosawa M, Kim SH, Nukina N, Takimoto E, et al. Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease. The Journal of Clinical Investigation. PMID 28263187 DOI: 10.1172/JCI85594  0.96
2017 Lavoie J, Gassó Astorga P, Segal-Gavish H, Wu YC, Chung Y, Cascella NG, Sawa A, Ishizuka K. The Olfactory Neural Epithelium As a Tool in Neuroscience. Trends in Molecular Medicine. PMID 28108112 DOI: 10.1016/j.molmed.2016.12.010  0.96
2016 Tankou S, Ishii K, Elliott C, Yalla KC, Day JP, Furukori K, Kubo KI, Brandon NJ, Tang Q, Hayward G, Nakajima K, Houslay MD, Kamiya A, Baillie G, Ishizuka K, et al. SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Molecular Neuropsychiatry. 2: 20-27. PMID 27525255 DOI: 10.1159/000444257  0.96
2016 Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A. Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1. Neuroscience Research. PMID 27354230 DOI: 10.1016/j.neures.2016.06.006  0.96
2016 Sawa A, Ishizuka K, Katsanis N. The potential of DISC1 protein as a therapeutic target for mental illness. Expert Opinion On Therapeutic Targets. PMID 26810812 DOI: 10.1517/14728222.2016.1146694  0.56
2015 Seshadri S, Faust T, Ishizuka K, Delevich K, Chung Y, Kim SH, Cowles M, Niwa M, Jaaro-Peled H, Tomoda T, Lai C, Anton ES, Li B, Sawa A. Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. Nature Communications. 6: 10118. PMID 26656849 DOI: 10.1038/ncomms10118  0.96
2015 Passeri E, Jones-Brando L, Bordón C, Sengupta S, Wilson AM, Primerano A, Rapoport JL, Ishikuza K, Kano SI, Yolken RH, Sawa A. Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls. Microbes and Infection / Institut Pasteur. PMID 26432947 DOI: 10.1016/j.micinf.2015.09.023  0.36
2015 Passeri E, Wilson AM, Primerano A, Kondo MA, Sengupta S, Srivastava R, Koga M, Obie C, Zandi PP, Goes FS, Valle D, Rapoport JL, Sawa A, Kano SI, Ishizuka K. Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. Neuroscience Research. PMID 26260244 DOI: 10.1016/j.neures.2015.07.011  0.8
2015 Barodia SK, Park SK, Ishizuka K, Sawa A, Kamiya A. Half-life of DISC1 protein and its pathological significance under hypoxia stress. Neuroscience Research. 97: 1-6. PMID 25738396 DOI: 10.1016/j.neures.2015.02.008  0.8
2015 Kano S, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, et al. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. Current Molecular Medicine. 15: 138-45. PMID 25732146  0.8
2015 Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A. Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade. The Journal of Biological Chemistry. 290: 56-64. PMID 25391652 DOI: 10.1074/jbc.M114.596205  0.8
2015 Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. DISC1 regulates trafficking and processing of APP and Aβ generation. Molecular Psychiatry. 20: 874-9. PMID 25224257 DOI: 10.1038/mp.2014.100  0.8
2014 Narayan S, McLean C, Sawa A, Lin SY, Rai N, Hipolito MS, Cascella N, Nurnberger JJ, Ishizuka K, Nwulia EA. Olfactory neurons obtained through nasal biopsy combined with laser-capture microdissection: a potential approach to study treatment response in mental disorders. Journal of Visualized Experiments : Jove. PMID 25549156 DOI: 10.3791/51853  0.8
2013 Horiuchi Y, Kano S, Ishizuka K, Cascella NG, Ishii S, Talbot CC, Jaffe AE, Okano H, Pevsner J, Colantuoni C, Sawa A. Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Neuroscience Research. 77: 247-50. PMID 24120685 DOI: 10.1016/j.neures.2013.09.010  0.8
2013 Soda T, Frank C, Ishizuka K, Baccarella A, Park YU, Flood Z, Park SK, Sawa A, Tsai LH. DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Molecular Psychiatry. 18: 898-908. PMID 23587879 DOI: 10.1038/mp.2013.38  0.8
2013 Coughlin JM, Ishizuka K, Kano SI, Edwards JA, Seifuddin FT, Shimano MA, Daley EL, Zandi PP, Leweke FM, Cascella NG, Pomper MG, Yolken RH, Sawa A. Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Molecular Psychiatry. 18: 10-1. PMID 22349781 DOI: 10.1038/mp.2012.6  0.8
2012 Bader V, Tomppo L, Trossbach SV, Bradshaw NJ, Prikulis I, Leliveld SR, Lin CY, Ishizuka K, Sawa A, Ramos A, Rosa I, García Á, Requena JR, Hipolito M, Rai N, et al. Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Human Molecular Genetics. 21: 4406-18. PMID 22798627 DOI: 10.1093/hmg/dds273  0.8
2011 Ishizuka K, Kamiya A, Oh EC, Kanki H, Seshadri S, Robinson JF, Murdoch H, Dunlop AJ, Kubo K, Furukori K, Huang B, Zeledon M, Hayashi-Takagi A, Okano H, Nakajima K, et al. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. 473: 92-6. PMID 21471969 DOI: 10.1038/nature09859  0.8
2011 Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry. 16: 1006-23. PMID 20838393 DOI: 10.1038/mp.2010.87  0.8
2010 Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F, Pogorelov V, Ladenheim B, Yang C, Krasnova IN, Cadet JL, Pardo C, Mori S, Kamiya A, Vogel MW, et al. Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biological Psychiatry. 68: 1172-81. PMID 21130225 DOI: 10.1016/j.biopsych.2010.09.022  0.8
2010 Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences of the United States of America. 107: 5622-7. PMID 20212127 DOI: 10.1073/pnas.0909284107  0.8
2010 Tajinda K, Ishizuka K, Colantuoni C, Morita M, Winicki J, Le C, Lin S, Schretlen D, Sawa A, Cascella NG. Neuronal biomarkers from patients with mental illnesses: a novel method through nasal biopsy combined with laser-captured microdissection. Molecular Psychiatry. 15: 231-2. PMID 20168323 DOI: 10.1038/mp.2009.73  0.8
2010 Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, et al. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature Neuroscience. 13: 327-32. PMID 20139976 DOI: 10.1038/nn.2487  0.8
2010 Ishizuka K, Tajinda K, Colantuoni C, Morita M, Winicki J, Le C, Lin S, Schretlen D, Sawa A, Cascella NG. Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test. Neuroscience Research. 66: 106-10. PMID 19819272 DOI: 10.1016/j.neures.2009.10.001  0.8
2008 Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch LA, Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, et al. Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Molecular Psychiatry. 13: 1138-48, 1069. PMID 18762802 DOI: 10.1038/mp.2008.101  0.8
2008 Kamiya A, Tan PL, Kubo K, Engelhard C, Ishizuka K, Kubo A, Tsukita S, Pulver AE, Nakajima K, Cascella NG, Katsanis N, Sawa A. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Archives of General Psychiatry. 65: 996-1006. PMID 18762586 DOI: 10.1001/archpsyc.65.9.996  0.8
2008 Burdick KE, Kamiya A, Hodgkinson CA, Lencz T, DeRosse P, Ishizuka K, Elashvili S, Arai H, Goldman D, Sawa A, Malhotra AK. Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Human Molecular Genetics. 17: 2462-73. PMID 18469341 DOI: 10.1093/hmg/ddn146  0.8
2007 Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y, Clapcote SJ, Hookway C, Morita M, Kamiya A, Tomoda T, Lipska BK, Roder JC, Pletnikov M, Porteous D, et al. Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Molecular Psychiatry. 12: 897-9. PMID 17895924 DOI: 10.1038/sj.mp.4002024  0.8
2007 Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences of the United States of America. 104: 14501-6. PMID 17675407 DOI: 10.1073/pnas.0704774104  0.8
2006 Hayashida Y, Hirai T, Korogi Y, Kimura T, Ishizuka K, Kawanaka K, Yamura M, Kitajima M, Ikushima I, Yamashita Y. Usefulness of measurement of the temporal stem on magnetic resonance imaging in the diagnosis of frontotemporal dementia. Acta Radiologica (Stockholm, Sweden : 1987). 47: 603-8. PMID 16875340 DOI: 10.1080/02841850600776295  0.8
2006 Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis MG, Sawa A. Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biological Psychiatry. 60: 929-35. PMID 16814263 DOI: 10.1016/j.biopsych.2006.03.032  0.8
2006 Ishizuka K, Paek M, Kamiya A, Sawa A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biological Psychiatry. 59: 1189-97. PMID 16797264 DOI: 10.1016/j.biopsych.2006.03.065  0.8
2005 Yamamoto H, Hiragami Y, Murayama M, Ishizuka K, Kawahara M, Takashima A. Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain. Journal of Neurochemistry. 94: 1438-47. PMID 16000144 DOI: 10.1111/j.1471-4159.2005.03307.x  0.8
2002 Ishizuka K, Kimura T, Yoshitake J, Akaike T, Shono M, Takamatsu J, Katsuragi S, Kitamura T, Miyakawa T. Possible assessment for antioxidant capacity in Alzheimer's disease by measuring lymphocyte heme oxygenase-1 expression with real-time RT-PCR. Annals of the New York Academy of Sciences. 977: 173-8. PMID 12480749  0.8
2000 Kimura T, Shono M, Yokota S, Ishizuka K, Watanabe M, Takamatsu J, Miyakawa T. Apolipoprotein E epsilon4 and tardive dyskinesia in a Japanese population. Journal of Psychiatric Research. 34: 329-32. PMID 11104846 DOI: 10.1016/S0022-3956(00)00023-6  0.8
2000 Katsuragi S, Teraoka K, Ikegami K, Amano K, Yamashita K, Ishizuka K, Miyakawa T. Late onset X-linked hydrocephalus with normal cerebrospinal fluid pressure Psychiatry and Clinical Neurosciences. 54: 487-492. PMID 10997867 DOI: 10.1046/j.1440-1819.2000.00740.x  0.8
2000 Miyakawa T, Kimura T, Hirata S, Fujise N, Ono T, Ishizuka K, Nakabayashi J. Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease Annals of the New York Academy of Sciences. 903: 46-54. PMID 10818488  0.8
1998 Shimoji A, Eguchi S, Ishizuka K, Cho T, Miyakawa T. Mediation between the shamanistic model and the psychiatric model in a shamanistic climate: A viewpoint of medical anthropology Psychiatry and Clinical Neurosciences. 52: 581-586. PMID 9895205 DOI: 10.1046/j.1440-1819.1998.00456.x  0.8
1997 Miyakawa T, Katsuragi S, Higuchi Y, Yamashita K, Kimura T, Teraoka K, Ono T, Ishizuka K. Changes of microvessels in the brain with Alzheimer's disease Annals of the New York Academy of Sciences. 826: 428-432. PMID 9329717 DOI: 10.1111/j.1749-6632.1997.tb48497.x  0.8
1997 Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdenakker G, Van Damme J, Yoshie O, Nomiyama H. A Novel Human CC Chemokine PARC That Is Most Homologous to Macrophage-Inflammatory Protein-1α/LD78α and Chemotactic for T Lymphocytes, but Not for Monocytes Journal of Immunology. 159: 1140-1149. PMID 9233607  0.8
1997 Ishizuka K, Kimura T, Igata-yi R, Katsuragi S, Takamatsu J, Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry and Clinical Neurosciences. 51: 135-8. PMID 9225377  0.8
1997 Ishizuka K, Igata-Yi R, Kimura T, Hieshima K, Kukita T, Kin Y, Misumi Y, Yamamoto M, Nomiyama H, Miura R, Takamatsu J, Katsuragi S, Miyakawa T. Expression and distribution of CC chemokine macrophage inflammatory protein-1 alpha/LD78 in the human brain. Neuroreport. 8: 1215-8. PMID 9175116  0.8
1997 Igata-Yi R, Igata T, Ishizuka K, Kimura T, Sakamoto S, Katsuragi S, Takamatsu J, Miyakawa T. Apolipoprotein E genotype and psychosis. Biological Psychiatry. 41: 906-8. PMID 9099418 DOI: 10.1016/S0006-3223(97)00015-2  0.8
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