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Ira Pastan - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
Molecular Biology
Website:
http://ccr.nci.nih.gov/staff/staff.asp?profileid=5782

230 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bera TK, Liu W, Leshem J, King E, Kozlov S, Pastan I. Generation of a Transgenic BALB/c Mouse Line With Selective Expression of Human Mesothelin in Thyroid Gland: Application in Mesothelin-targeted Immunotherapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 30933045 DOI: 10.1097/CJI.0000000000000263  0.308
2018 Wei J, Bera TK, Liu XF, Zhou Q, Onda M, Ho M, Tai CH, Pastan I. Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581296 DOI: 10.1073/pnas.1721780115  0.331
2018 Müller F, Cunningham T, Stookey S, Tai CH, Burkett S, Jailwala P, Stetler Stevenson M, Cam MC, Wayne AS, Pastan I. 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432154 DOI: 10.1073/pnas.1714512115  0.308
2017 Liu XF, Zhou Q, Hassan R, Pastan I. Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway. Oncotarget. 8: 87307-87316. PMID 29152082 DOI: 10.18632/oncotarget.20263  0.309
2017 Bera TK, Abe Y, Ise T, Oberle A, Gallardo D, Liu XF, Nagata S, Binder M, Pastan I. Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients. Leukemia. PMID 29149102 DOI: 10.1038/leu.2017.315  0.308
2017 Mazor R, Kaplan G, Park D, Jang Y, Lee F, Kreitman R, Pastan I. Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38. Cellular Immunology. PMID 28087047 DOI: 10.1016/j.cellimm.2017.01.003  0.309
2016 Hassan R, Thomas A, Alewine C, Le DT, Jaffee EM, Pastan I. Mesothelin Immunotherapy for Cancer: Ready for Prime Time? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 4171-4179. PMID 27863199 DOI: 10.1200/Jco.2016.68.3672  0.303
2016 Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ. Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. Plos One. 11: e0161415. PMID 27556570 DOI: 10.1371/Journal.Pone.0161415  0.313
2016 Awuah P, Bera TK, Folivi M, Chertov O, Pastan I. Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin Targeting Recombinant Immunotoxins. Molecular Cancer Therapeutics. PMID 27196771 DOI: 10.1158/1535-7163.MCT-15-0863  0.312
2016 Mazor R, Onda M, Park D, Addissie S, Xiang L, Zhang J, Hassan R, Pastan I. Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity. Oncotarget. PMID 27167198 DOI: 10.18632/oncotarget.9171  0.321
2016 Alewine C, Landsman R, Rudloff M, Kolyvas E, Chen J, Pastan I. Abstract B37: Mesothelin-targeted immunotoxin RG7787 (LMB-100) preferentially depletes secreted proteins and short-lived intracellular proteins to augment tumor cell killing by taxanes Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B37  0.308
2015 Kreitman RJ, Pastan I. Immunoconjugates in the management of hairy cell leukemia. Best Practice & Research. Clinical Haematology. 28: 236-45. PMID 26614902 DOI: 10.1016/j.beha.2015.09.003  0.312
2015 Mazor R, Zhang J, Xiang L, Addissie S, Awuah P, Beers R, Hassan R, Pastan I. Recombinant Immunotoxin with T Cell Epitope Mutations that Greatly Reduce Immunogenicity for Treatment of Mesothelin Expressing Tumors. Molecular Cancer Therapeutics. PMID 26443804 DOI: 10.1158/1535-7163.MCT-15-0532  0.308
2015 Stahl S, da Silva Mateus Seidl AR, Ducret A, Kux van Geijtenbeek S, Michel S, Racek T, Birzele F, Haas AK, Rueger R, Gerg M, Niederfellner G, Pastan I, Brinkmann U. Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Proceedings of the National Academy of Sciences of the United States of America. 112: 10732-7. PMID 26261303 DOI: 10.1073/pnas.1512863112  0.322
2015 Weldon JE, Skarzynski M, Therres JA, Ostovitz JR, Zhou H, Kreitman RJ, Pastan I. Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. Bioconjugate Chemistry. 26: 1120-8. PMID 25997032 DOI: 10.1021/Acs.Bioconjchem.5B00190  0.316
2015 Zhang YF, Phung Y, Gao W, Kawa S, Hassan R, Pastan I, Ho M. New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma. Scientific Reports. 5: 9928. PMID 25996440 DOI: 10.1038/srep09928  0.315
2015 Hollevoet K, Mason-Osann E, Müller F, Pastan I. Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line. Plos One. 10: e0122462. PMID 25803818 DOI: 10.1371/journal.pone.0122462  0.302
2015 Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: E1135-42. PMID 25713356 DOI: 10.1073/Pnas.1501958112  0.315
2015 Leshem J, Liu X, Bera T, Terabe M, Berzofsky JA, Bossenmaier B, Niederfellner G, Pastan I. Combining anti-CTLA4 with RG7787, an immunotoxin targeting mesothelin, promotes tumor eradication Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P190  0.308
2014 Pak Y, Pastan I, Kreitman RJ, Lee B. Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model. Plos One. 9: e110716. PMID 25343405 DOI: 10.1371/journal.pone.0110716  0.303
2014 Wright SE, Rewers-Felkins KA, Quinlin I, Chowdhury NI, Ahmed J, Eldridge PW, Srivastava SK, Pastan I. TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells. Oncology Letters. 7: 2113-2117. PMID 24932299 DOI: 10.3892/ol.2014.1969  0.313
2014 Mazor R, Eberle JA, Hu X, Vassall AN, Onda M, Beers R, Lee EC, Kreitman RJ, Lee B, Baker D, King C, Hassan R, Benhar I, Pastan I. Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 111: 8571-6. PMID 24799704 DOI: 10.1073/Pnas.1405153111  0.58
2013 Hassan R, Miller AC, Sharon E, Thomas A, Reynolds JC, Ling A, Kreitman RJ, Miettinen MM, Steinberg SM, Fowler DH, Pastan I. Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Science Translational Medicine. 5: 208ra147. PMID 24154601 DOI: 10.1126/scitranslmed.3006941  0.309
2013 Huang YH, Terabe M, Pendleton CD, Stewart Khursigara D, Bera TK, Pastan I, Berzofsky JA. Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE. Plos One. 8: e64365. PMID 23750208 DOI: 10.1371/journal.pone.0064365  0.301
2013 Choi BD, Pastan I, Bigner DD, Sampson JH. A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system. Oncoimmunology. 2: e23639. PMID 23734318 DOI: 10.4161/Onci.23639  0.3
2013 Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. The Journal of Biological Chemistry. 288: 12305-12. PMID 23486472 DOI: 10.1074/jbc.M113.461343  0.304
2013 Choi BD, Kuan CT, Cai M, Archer GE, Mitchell DA, Gedeon PC, Sanchez-Perez L, Pastan I, Bigner DD, Sampson JH. Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proceedings of the National Academy of Sciences of the United States of America. 110: 270-5. PMID 23248284 DOI: 10.1073/Pnas.1219817110  0.32
2013 Weldon JE, Xiang L, Zhang J, Beers R, Walker DA, Onda M, Hassan R, Pastan I. A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity. Molecular Cancer Therapeutics. 12: 48-57. PMID 23136186 DOI: 10.1158/1535-7163.Mct-12-0336  0.313
2013 Mazor R, Vassall AN, Eberle JA, Beers R, Hu X, Benhar I, Pastan I. Abstract 4334: Identification and elimination of T-cell epitopes in recombinant immunotoxins used to treat cancer. Cancer Research. 73: 4334-4334. DOI: 10.1158/1538-7445.Am2013-4334  0.586
2012 Mazor R, Vassall AN, Eberle JA, Beers R, Weldon JE, Venzon DJ, Tsang KY, Benhar I, Pastan I. Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. Proceedings of the National Academy of Sciences of the United States of America. 109: E3597-603. PMID 23213206 DOI: 10.1073/Pnas.1218138109  0.59
2012 Tortorella LL, Pipalia NH, Mukherjee S, Pastan I, Fitzgerald D, Maxfield FR. Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary. Plos One. 7: e47320. PMID 23056628 DOI: 10.1371/Journal.Pone.0047320  0.542
2012 Liu W, Onda M, Lee B, Kreitman RJ, Hassan R, Xiang L, Pastan I. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11782-7. PMID 22753489 DOI: 10.1073/pnas.1209292109  0.338
2012 Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. Plos One. 7: e38130. PMID 22666460 DOI: 10.1371/journal.pone.0038130  0.302
2012 Pak Y, Zhang Y, Pastan I, Lee B. Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors. Cancer Research. 72: 3143-52. PMID 22562466 DOI: 10.1158/0008-5472.CAN-11-3925  0.302
2012 Baskar S, Wiestner A, Wilson WH, Pastan I, Rader C. Targeting malignant B cells with an immunotoxin against ROR1. Mabs. 4: 349-61. PMID 22531447 DOI: 10.4161/Mabs.19870  0.32
2012 Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I. A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Engineering, Design & Selection : Peds. 25: 1-6. PMID 22101015 DOI: 10.1093/Protein/Gzr053  0.304
2012 Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I. CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis. Oncogene. 31: 1673-82. PMID 21822313 DOI: 10.1038/onc.2011.355  0.309
2011 Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6398-405. PMID 22003067 DOI: 10.1158/1078-0432.CCR-11-0487  0.333
2011 Zhang Y, Chertov O, Zhang J, Hassan R, Pastan I. Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. Cancer Research. 71: 5915-22. PMID 21775520 DOI: 10.1158/0008-5472.CAN-11-0466  0.307
2011 Fitzgerald DJ, Moskatel E, Ben-Josef G, Traini R, Tendler T, Sharma A, Antignani A, Mussai F, Wayne A, Kreitman RJ, Pastan I. Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737. Leukemia & Lymphoma. 52: 79-81. PMID 21599608 DOI: 10.3109/10428194.2011.569961  0.323
2011 Pastan I, Onda M, Weldon J, Fitzgerald D, Kreitman R. Immunotoxins with decreased immunogenicity and improved activity. Leukemia & Lymphoma. 52: 87-90. PMID 21504287 DOI: 10.3109/10428194.2011.573039  0.329
2011 Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, Pastan I. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 108: 5742-7. PMID 21436054 DOI: 10.1073/Pnas.1102746108  0.326
2011 Ho M, Feng M, Fisher RJ, Rader C, Pastan I. A novel high-affinity human monoclonal antibody to mesothelin. International Journal of Cancer. Journal International Du Cancer. 128: 2020-30. PMID 20635390 DOI: 10.1002/Ijc.25557  0.315
2011 Kreitman RJ, Singh R, Stetler-Stevenson M, Waldmann TA, Pastan I. Regression of Adult T-Cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 Preceded by Chemotherapy Blood. 118: 2575-2575. DOI: 10.1182/Blood.V118.21.2575.2575  0.309
2010 Hansen JK, Weldon JE, Xiang L, Beers R, Onda M, Pastan I. A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 297-304. PMID 20445350 DOI: 10.1097/Cji.0B013E3181Cd1164  0.316
2010 Bogner C, Dechow T, Ringshausen I, Wagner M, Oelsner M, Lutzny G, Licht T, Peschel C, Pastan I, Kreitman RJ, Decker T. Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression. British Journal of Haematology. 148: 99-109. PMID 19821820 DOI: 10.1111/j.1365-2141.2009.07939.x  0.316
2010 Pastan I, Roth J, Macchia V. Binding of hormone to tissue: the first step in polypeptide hormone action. Proceedings of the National Academy of Sciences of the United States of America. 56: 1802-9. PMID 16591423 DOI: 10.1073/PNAS.56.6.1802  0.348
2009 Xiao X, Ho M, Zhu Z, Pastan I, Dimitrov DS. Identification and characterization of fully human anti-CD22 monoclonal antibodies. Mabs. 1: 297-303. PMID 20065646 DOI: 10.4161/mabs.1.3.8113  0.31
2009 Liu XF, Bera TK, Liu LJ, Pastan I. A primate-specific POTE-actin fusion protein plays a role in apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 14: 1237-44. PMID 19669888 DOI: 10.1007/s10495-009-0392-0  0.317
2009 Ho M, Pastan I. Display and selection of scFv antibodies on HEK-293T cells. Methods in Molecular Biology (Clifton, N.J.). 562: 99-113. PMID 19554290 DOI: 10.1007/978-1-60327-302-2_8  0.328
2009 Feng Y, Xiao X, Zhu Z, Streaker E, Ho M, Pastan I, Dimitrov DS. A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity. Molecular Cancer Therapeutics. 8: 1113-8. PMID 19417159 DOI: 10.1158/1535-7163.MCT-08-0945  0.323
2009 Ho M, Pastan I. Mammalian cell display for antibody engineering. Methods in Molecular Biology (Clifton, N.J.). 525: 337-52, xiv. PMID 19252852 DOI: 10.1007/978-1-59745-554-1_18  0.321
2009 Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. Biochemical and Biophysical Research Communications. 380: 508-13. PMID 19250639 DOI: 10.1016/J.Bbrc.2009.01.089  0.309
2009 Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proceedings of the National Academy of Sciences of the United States of America. 106: 3360-5. PMID 19211796 DOI: 10.1073/Pnas.0813101106  0.313
2008 Laheru DA, Cohen SJ, Phillips M, Armstrong DK, Brahmer J, Jaffee EM, Weil S, Pastan I, Hassan R. A phase I study of MORab-009, a monoclonal antibody against mesothelin, in mesothelioma, pancreatic and ovarian cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3578. PMID 27949713 DOI: 10.1200/Jco.2008.26.15_Suppl.3578  0.319
2008 Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Research. 68: 6306-12. PMID 18676855 DOI: 10.1158/0008-5472.CAN-08-0870  0.319
2008 Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman DS, Pera M, Pastan I. Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. Stem Cells and Development. 17: 325-32. PMID 18447647 DOI: 10.1089/Scd.2007.0079  0.315
2008 Epel M, Carmi I, Soueid-Baumgarten S, Oh SK, Bera T, Pastan I, Berzofsky J, Reiter Y. Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies. European Journal of Immunology. 38: 1706-20. PMID 18446790 DOI: 10.1002/eji.200737524  0.325
2008 Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. The Journal of Biological Chemistry. 283: 16928-39. PMID 18387948 DOI: 10.1074/Jbc.M801454200  0.3
2008 Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I. Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochemical and Biophysical Research Communications. 365: 603-8. PMID 17996727 DOI: 10.1016/j.bbrc.2007.10.195  0.306
2007 Yokokawa J, Bera TK, Palena C, Cereda V, Remondo C, Gulley JL, Arlen PM, Pastan I, Schlom J, Tsang KY. Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4). International Journal of Cancer. Journal International Du Cancer. 121: 595-605. PMID 17397028 DOI: 10.1002/ijc.22698  0.302
2007 Das S, Hahn Y, Nagata S, Willingham MC, Bera TK, Lee B, Pastan I. NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Research. 67: 1594-601. PMID 17308099 DOI: 10.1158/0008-5472.CAN-06-2673  0.302
2006 Onda M, Nagata S, FitzGerald DJ, Beers R, Fisher RJ, Vincent JJ, Lee B, Nakamura M, Hwang J, Kreitman RJ, Hassan R, Pastan I. Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. Journal of Immunology (Baltimore, Md. : 1950). 177: 8822-34. PMID 17142785 DOI: 10.4049/Jimmunol.177.12.8822  0.319
2006 Ho M, Nagata S, Pastan I. Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 9637-42. PMID 16763048 DOI: 10.1073/pnas.0603653103  0.337
2006 Egland KA, Liu XF, Squires S, Nagata S, Man YG, Bera TK, Onda M, Vincent JJ, Strausberg RL, Lee B, Pastan I. High expression of a cytokeratin-associated protein in many cancers. Proceedings of the National Academy of Sciences of the United States of America. 103: 5929-34. PMID 16585525 DOI: 10.1073/Pnas.0601296103  0.303
2006 Attia P, Powell DJ, Maker AV, Kreitman RJ, Pastan I, Rosenberg SA. Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2. Journal of Immunotherapy (Hagerstown, Md. : 1997). 29: 208-14. PMID 16531821 DOI: 10.1097/01.cji.0000187959.45803.0c  0.301
2005 Yokokawa J, Palena C, Arlen P, Hassan R, Ho M, Pastan I, Schlom J, Tsang KY. Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 6342-51. PMID 16144939 DOI: 10.1158/1078-0432.CCR-05-0596  0.317
2005 Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 5840-6. PMID 16115924 DOI: 10.1158/1078-0432.CCR-05-0578  0.322
2005 Soler-García AA, Maitra R, Kumar V, Ise T, Nagata S, Beers R, Bera TK, Pastan I. The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein. Reproduction (Cambridge, England). 129: 515-24. PMID 15798027 DOI: 10.1530/rep.1.00576  0.309
2005 Ho M, Kreitman RJ, Onda M, Pastan I. In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. The Journal of Biological Chemistry. 280: 607-17. PMID 15491997 DOI: 10.1074/jbc.M409783200  0.315
2004 Hassan R, Bera T, Pastan I. Mesothelin: a new target for immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3937-42. PMID 15217923 DOI: 10.1158/1078-0432.CCR-03-0801  0.312
2004 Maeda H, Nagata S, Wolfgang CD, Bratthauer GL, Bera TK, Pastan I. The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. The Journal of Biological Chemistry. 279: 24561-8. PMID 15150260 DOI: 10.1074/jbc.M402492200  0.311
2004 FitzGerald DJ, Kreitman R, Wilson W, Squires D, Pastan I. Recombinant immunotoxins for treating cancer. International Journal of Medical Microbiology : Ijmm. 293: 577-82. PMID 15149034 DOI: 10.1078/1438-4221-00302  0.348
2004 Oh S, Terabe M, Pendleton CD, Bhattacharyya A, Bera TK, Epel M, Reiter Y, Phillips J, Linehan WM, Kasten-Sportes C, Pastan I, Berzofsky JA. Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells. Cancer Research. 64: 2610-8. PMID 15059918 DOI: 10.1158/0008-5472.Can-03-2183  0.304
2004 Decker T, Wagner M, Oelsner M, Kreitman RJ, Pastan I, Peschel C, Licht T. BL22, a Recombinant Anti-CD22 Immunotoxin, Induces Cell Cycle Arrest and Apoptosis in B-Cell Lymphoma. Blood. 104: 4613-4613. DOI: 10.1182/BLOOD.V104.11.4613.4613  0.325
2002 McHugh L, Hu S, Lee BK, Santora K, Kennedy PE, Berger EA, Pastan I, Hamer DH. Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis. The Journal of Biological Chemistry. 277: 34383-90. PMID 12119300 DOI: 10.1074/jbc.M205456200  0.31
2002 Salvatore G, Nagata S, Billaud M, Santoro M, Vecchio G, Pastan I. Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase. Biochemical and Biophysical Research Communications. 294: 813-7. PMID 12061779 DOI: 10.1016/S0006-291X(02)00560-0  0.302
2002 Decker T, Hipp S, Kreitman RJ, Pastan I, Peschel C, Licht T. Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. Blood. 99: 1320-6. PMID 11830482 DOI: 10.1182/blood.V99.4.1320  0.305
2000 Wolfgang CD, Essand M, Vincent JJ, Lee B, Pastan I. TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus. Proceedings of the National Academy of Sciences of the United States of America. 97: 9437-42. PMID 10931945 DOI: 10.1073/pnas.160270597  0.312
2000 Hassan R, Viner JL, Wang QC, Margulies I, Kreitman RJ, Pastan I. Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 473-9. PMID 10916757 DOI: 10.1097/00002371-200007000-00011  0.326
2000 Shen DW, Goldenberg S, Pastan I, Gottesman MM. Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. Journal of Cellular Physiology. 183: 108-16. PMID 10699972 DOI: 10.1002/(Sici)1097-4652(200004)183:1<108::Aid-Jcp13>3.0.Co;2-4  0.302
1999 Chowdhury PS, Pastan I. Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations. Journal of Immunological Methods. 231: 83-91. PMID 10648929 DOI: 10.1016/S0022-1759(99)00142-8  0.304
1998 Bera TK, Pastan I. Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability. Bioconjugate Chemistry. 9: 736-43. PMID 9815167 DOI: 10.1021/bc980028o  0.318
1998 Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Biochemistry. 37: 13660-73. PMID 9753453 DOI: 10.1021/Bi9808823  0.308
1998 Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. Methods in Enzymology. 292: 456-73. PMID 9711574 DOI: 10.1016/S0076-6879(98)92035-3  0.301
1998 Almog O, Benhar I, Vasmatzis G, Tordova M, Lee B, Pastan I, Gilliland GL. Crystal structure of the disulfide-stabilized Fv fragment of anticancer antibody B1: conformational influence of an engineered disulfide bond. Proteins. 31: 128-38. PMID 9593187 DOI: 10.1002/(Sici)1097-0134(19980501)31:2<128::Aid-Prot3>3.0.Co;2-I  0.579
1998 Chowdhury PS, Viner JL, Beers R, Pastan I. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 669-74. PMID 9435250 DOI: 10.1073/Pnas.95.2.669  0.336
1997 Funatomi H, Itakura J, Ishiwata T, Pastan I, Thompson SA, Johnson GR, Korc M. Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy. International Journal of Cancer. 72: 512-7. PMID 9247297 DOI: 10.1002/(Sici)1097-0215(19970729)72:3<512::Aid-Ijc21>3.0.Co;2-C  0.315
1997 Chowdhury PS, Chang K, Pastan I. Isolation of anti-mesothelin antibodies from a phage display library. Molecular Immunology. 34: 9-20. PMID 9182872 DOI: 10.1016/S0161-5890(97)00011-4  0.315
1996 Lorimer IA, Keppler-Hafkemeyer A, Beers RA, Pegram CN, Bigner DD, Pastan I. Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display. Proceedings of the National Academy of Sciences of the United States of America. 93: 14815-20. PMID 8962138 DOI: 10.1073/pnas.93.25.14815  0.328
1996 Ramachandra M, Ambudkar SV, Gottesman MM, Pastan I, Hrycyna CA. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Molecular Biology of the Cell. 7: 1485-98. PMID 8898356 DOI: 10.1091/Mbc.7.10.1485  0.307
1996 Mansfield E, Pastan I, FitzGerald DJ. Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies Bioconjugate Chemistry. 7: 557-563. PMID 8889017 DOI: 10.1021/bc960043y  0.324
1996 Baldwin RL, Kobrin MS, Tran T, Pastan I, Korc M. Cytotoxic effects of TGF-α-Pseudomonas exotoxin A fusion protein in human pancreatic carcinoma cells Pancreas. 13: 16-21. PMID 8783329 DOI: 10.1097/00006676-199607000-00002  0.32
1996 Li M, Dyda F, Benhar I, Pastan I, Davies DR. Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. Proceedings of the National Academy of Sciences of the United States of America. 93: 6902-6. PMID 8692916 DOI: 10.1073/Pnas.93.14.6902  0.57
1996 Kuan CT, Pastan I. Improved antitumor activity of a recombinant anti-Lewisy immunotoxin not requiring proteolytic activation Proceedings of the National Academy of Sciences of the United States of America. 93: 974-978. PMID 8577771 DOI: 10.1073/PNAS.93.3.974  0.308
1995 Kreitman RJ, Pastan I. Targeting Pseudomonas exotoxin to hematologic malignancies Seminars in Cancer Biology. 6: 297-306. PMID 8562907 DOI: 10.1006/SCBI.1995.0038  0.333
1995 Benhar I, Padlan EA, Jung SH, Lee B, Pastan I. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38. Proceedings of the National Academy of Sciences of the United States of America. 91: 12051-5. PMID 7991583 DOI: 10.1073/Pnas.91.25.12051  0.574
1995 Brinkmann U, Chowdhury PS, Roscoe DM, Pastan I. Phage display of disulfide-stabilized Fv fragments. Journal of Immunological Methods. 182: 41-50. PMID 7769243 DOI: 10.1016/0022-1759(95)00016-4  0.311
1995 Benhar I, Pastan I. Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins. Protein Engineering. 7: 1509-15. PMID 7716163 DOI: 10.1093/Protein/7.12.1509  0.593
1995 Shen DW, Akiyama S, Schoenlein P, Pastan I, Gottesman MM. Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. British Journal of Cancer. 71: 676-83. PMID 7710928 DOI: 10.1038/Bjc.1995.134  0.321
1995 Benhar I, Reiter Y, Pai LH, Pastan I. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice. International Journal of Cancer. 62: 351-5. PMID 7628878 DOI: 10.1002/Ijc.2910620320  0.565
1995 Debinski W, Obiri NI, Pastan I, Puri RK. A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4 Journal of Biological Chemistry. 270: 16775-16780. PMID 7622490 DOI: 10.1074/jbc.270.28.16775  0.326
1995 Li M, Dyda F, Benhar I, Pastan I, Davies DR. The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 92: 9308-12. PMID 7568123 DOI: 10.1073/Pnas.92.20.9308  0.565
1995 Benhar I, Pastan I. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3. The Journal of Biological Chemistry. 270: 23373-80. PMID 7559495 DOI: 10.1074/Jbc.270.40.23373  0.583
1994 Debinski W, Pastan I. An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin Bioconjugate Chemistry. 5: 40-46. PMID 8199233 DOI: 10.1021/Bc00025A006  0.302
1994 Puri RK, Debinski W, Obiri N, Kreitman R, Pastan I. Human Renal Cell Carcinoma Cells Are Sensitive to the Cytotoxic Effect of a Chimeric Protein Composed of Human Interleukin-4 and Pseudomonas Exotoxin Cellular Immunology. 154: 369-379. PMID 8131209 DOI: 10.1006/cimm.1994.1084  0.309
1994 Benhar I, Brinkmann U, Webber KO, Pastan I. Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization. Bioconjugate Chemistry. 5: 321-326. PMID 7948099 DOI: 10.1021/Bc00028A007  0.577
1994 Roscoe DM, Jung SH, Benhar I, Pai L, Lee BK, Pastan I. Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin. Infection and Immunity. 62: 5055-65. PMID 7927788 DOI: 10.1128/Iai.62.11.5055-5065.1994  0.574
1994 Siegall CB, Gawlak SL, Chace DF, Merwin JR, Pastan I. In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins. Bioconjugate Chemistry. 5: 77-83. PMID 7515280 DOI: 10.1021/bc00025a010  0.322
1993 Brinkmann U, Gallo M, Brinkmann E, Kunwar S, Pastan I. A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 90: 547-51. PMID 8421689 DOI: 10.1073/PNAS.90.2.547  0.313
1993 Kunwar S, Pai LH, Pastan I. Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. Journal of Neurosurgery. 79: 569-76. PMID 7692018 DOI: 10.3171/jns.1993.79.4.0569  0.325
1992 Kreitman RJ, Siegall CB, Chaudhary VK, FitzGerald DJ, Pastan I. Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin. Bioconjugate Chemistry. 3: 63-8. PMID 1616951 DOI: 10.1021/bc00013a010  0.308
1992 Batra JK, Kasprzyk PG, Bird RE, Pastan I, King CR. Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 89: 5867-71. PMID 1352878 DOI: 10.1073/Pnas.89.13.5867  0.331
1992 Chin KV, Chauhan SS, Abraham I, Sampson KE, Krolczyk AJ, Wong M, Schimmer B, Pastan I, Gottesman MM. Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines. Journal of Cellular Physiology. 152: 87-94. PMID 1352302 DOI: 10.1002/Jcp.1041520112  0.312
1992 Biro S, Siegall CB, Fu YM, Speir E, Pastan I, Epstein SE. In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells. Circulation Research. 71: 640-5. PMID 1323436 DOI: 10.1161/01.RES.71.3.640  0.301
1991 Batra JK, Fitzgerald DJ, Chaudhary VK, Pastan I. Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv). Molecular and Cellular Biology. 11: 2200-5. PMID 2005905 DOI: 10.1128/mcb.11.4.2200  0.329
1991 Epstein SE, Siegall CB, Biro S, Fu YM, FitzGerald D, Pastan I. Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation. 84: 778-87. PMID 1860221 DOI: 10.1161/01.CIR.84.2.778  0.324
1990 Batra JK, Chaudhary VK, FitzGerald D, Pastan I. TGF alpha-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors. Biochemical and Biophysical Research Communications. 171: 1-6. PMID 2393383 DOI: 10.1016/0006-291x(90)91347-u  0.315
1990 Chaudhary VK, Gallo MG, FitzGerald DJ, Pastan I. A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin. Proceedings of the National Academy of Sciences of the United States of America. 87: 9491-4. PMID 2251289 DOI: 10.1073/pnas.87.23.9491  0.321
1990 Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I. The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 87: 8291-5. PMID 2236041 DOI: 10.1073/Pnas.87.21.8291  0.324
1990 Chaudhary VK, Batra JK, Gallo MG, Willingham MC, FitzGerald DJ, Pastan I. A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins. Proceedings of the National Academy of Sciences of the United States of America. 87: 1066-70. PMID 2105495 DOI: 10.1073/pnas.87.3.1066  0.313
1989 Siegall CB, Xu YH, Chaudhary VK, Adhya S, Fitzgerald D, Pastan I. Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 2647-52. PMID 2556314 DOI: 10.1096/Fasebj.3.14.2556314  0.31
1989 Batra JK, Jinno Y, Chaudhary VK, Kondo T, Willingham MC, FitzGerald DJ, Pastan I. Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 86: 8545-9. PMID 2510169 DOI: 10.1073/pnas.86.21.8545  0.324
1989 Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature. 339: 394-7. PMID 2498664 DOI: 10.1038/339394A0  0.318
1988 Kane SE, Troen BR, Gal S, Ueda K, Pastan I, Gottesman MM. Use of cloned multidrug resistance gene for coamplification and overproduction of major excreted protein,a transformation-regulated secreted acid protease Molecular and Cellular Biology. 8: 3316-3321. PMID 2463474 DOI: 10.1128/Mcb.8.8.3316  0.322
1987 Hasumura S, Kitagawa S, Lovelace E, Willingham MC, Pastan I, Cheng S. Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies. Biochemistry. 25: 7881-8. PMID 3542039 DOI: 10.1021/bi00372a014  0.313
1987 Chaudhary VK, FitzGerald DJ, Adhya S, Pastan I. Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin. Proceedings of the National Academy of Sciences of the United States of America. 84: 4538-42. PMID 3299371 DOI: 10.1073/Pnas.84.13.4538  0.314
1986 Cheng SY, Hasumura S, Willingham MC, Pastan I. Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 83: 947-51. PMID 3006034 DOI: 10.1073/pnas.83.4.947  0.303
1986 King CR, Kraus MH, Williams LT, Merlino GT, Pastan IH, Aaronson SA. Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucleic Acids Research. 13: 8477-86. PMID 3001641 DOI: 10.1093/Nar/13.23.8477  0.56
1986 Pastan I, Hanover J, Willingham M. The cellular entry of EGF and transferrin: a problem in intracellular sorting. Current Topics in Cellular Regulation. 26: 17-25. PMID 3000694 DOI: 10.1016/B978-0-12-152826-3.50009-7  0.501
1986 Hanover JA, D'Souza P, August T, Pastan I, Willingham MC. Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit α2-macroglobulin binding and uptake Journal of Biological Chemistry. 261: 16732-16737. PMID 2430970  0.533
1985 Hanover JA, Pastan I, Willingham MC. Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts Experimental Cell Research. 157: 276-281. PMID 3972013 DOI: 10.1016/0014-4827(85)90170-3  0.551
1985 Pirker R, FitzGerald DJP, Hamilton TC, Ozols RF, Laird W, Frankel AE, Willingham MC, Pastan I. Characterization of immunotoxins active against ovarian cancer cell lines Journal of Clinical Investigation. 76: 1261-1267. PMID 3930572 DOI: 10.1172/Jci112082  0.317
1985 Akiyama Si, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Somatic Cell and Molecular Genetics. 11: 117-126. PMID 3856953 DOI: 10.1007/BF01534700  0.519
1985 Hunts JH, Shimizu N, Yamamoto T, Toyoshima K, Merlino GT, Xu YH, Pastan I. Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA. Somatic Cell and Molecular Genetics. 11: 477-84. PMID 2994239 DOI: 10.1007/Bf01534841  0.302
1985 Hanover JA, Beguinot L, Willingham MC, Pastan IH. Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry Journal of Biological Chemistry. 260: 15938-15945. PMID 2866188  0.492
1985 Beguinot L, Hanover JA, Ito S, Richert ND, Willingham MC, Pastan I. Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors Proceedings of the National Academy of Sciences of the United States of America. 82: 2774-2778. PMID 2859591 DOI: 10.1073/Pnas.82.9.2774  0.559
1985 Dickson RB, Hanover JA, Pastan I, Willingham MC. Isolation of receptosomes (endosomes) from human KB cells Methods in Enzymology. 257-271. PMID 2859514 DOI: 10.1016/0076-6879(85)09091-7  0.573
1984 Xu YH, Ishii S, Clark AJ, Sullivan M, Wilson RK, Ma DP, Roe BA, Merlino GT, Pastan I. Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature. 309: 806-10. PMID 6330563 DOI: 10.1038/309806a0  0.311
1984 McKeon C, Pastan I, de Crombrugghe B. DNase I sensitivity of the alpha 2(I) collagen gene: correlation with its expression but not with its methylation pattern. Nucleic Acids Research. 12: 3491-502. PMID 6328424 DOI: 10.1093/nar/12.8.3491  0.553
1984 Hanover JA, Willingham MC, Pastan I. Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes Cell. 39: 283-293. PMID 6149810 DOI: 10.1016/0092-8674(84)90006-0  0.546
1984 Willingham MC, Strader CD, Lefkowitz RJ, Pastan I. Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. Experimental Cell Research. 151: 573-7. PMID 6142826 DOI: 10.1016/0014-4827(84)90406-3  0.453
1984 Willingham MC, Hanover JA, Dickson RB, Pastan I. Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells Proceedings of the National Academy of Sciences of the United States of America. 81: 175-179. PMID 6141558 DOI: 10.1073/pnas.81.1.175  0.576
1984 Akiyama T, Yamada Y, Ogawara H, Richert N, Pastan I, Yamamoto T, Kasuga M. Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor. Biochemical and Biophysical Research Communications. 123: 797-802. PMID 6091642 DOI: 10.1016/0006-291X(84)90300-0  0.302
1984 Akiyama S, Gottesman MM, Hanover JA, Fitzgerald DJ, Willingham MC, Pastan I. Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin Journal of Cellular Physiology. 120: 271-279. PMID 6086678 DOI: 10.1002/jcp.1041200303  0.573
1983 Hanover JA, Rudick JE, Willingham MC, Pastan I. α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites Archives of Biochemistry and Biophysics. 227: 570-579. PMID 6667030 DOI: 10.1016/0003-9861(83)90486-1  0.553
1983 Hirano H, Yamada Y, Sullivan M, de Crombrugghe B, Pastan I, Yamada KM. Isolation of genomic DNA clones spanning the entire fibronectin gene. Proceedings of the National Academy of Sciences of the United States of America. 80: 46-50. PMID 6572007 DOI: 10.1073/pnas.80.1.46  0.633
1983 Dickson RB, Hanover JA, Willingham MC, Pastan I. Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis Biochemistry. 22: 5667-5674. PMID 6317024 DOI: 10.1021/Bi00293A033  0.549
1983 Dickson RB, Beguinot L, Hanover JA, Richert ND, Willingham MC, Pastan I. Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line Proceedings of the National Academy of Sciences of the United States of America. 80: 5335-5339. PMID 6310570 DOI: 10.1073/Pnas.80.17.5335  0.572
1983 FitzGerald DJ, Trowbridge IS, Pastan I, Willingham MC. Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus. Proceedings of the National Academy of Sciences of the United States of America. 80: 4134-8. PMID 6306663 DOI: 10.1073/Pnas.80.13.4134  0.305
1983 Hanover JA, Willingham MC, Pastan I. Receptor-mediated endocytosis of α2-macroglobulin: Solubilization and partial purification of the fibroblast α2-macroglobulin receptor Annals of the New York Academy of Sciences. 410-423. PMID 6202215 DOI: 10.1111/J.1749-6632.1983.Tb18135.X  0.566
1983 Merlino GT, McKeon C, de Crombrugghe B, Pastan I. Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development. The Journal of Biological Chemistry. 258: 10041-8. PMID 6193105  0.505
1983 Hanover JA, Cheng S, Willingham MC, Pastan IH. α2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites Journal of Biological Chemistry. 258: 370-377. PMID 6184373  0.51
1982 Tyagi JS, Merlino GT, de Crombrugghe B, Pastan I. Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system. The Journal of Biological Chemistry. 257: 13001-8. PMID 7130191  0.513
1982 Vogeli G, Ohkubo H, Sobel ME, Yamada Y, Pastan I, de Crombrugghe B. Structure of the promoter for chicken α2 type I collagen gene Proceedings of the National Academy of Sciences of the United States of America. 78: 5334-5338. PMID 6946474 DOI: 10.1073/pnas.78.9.5334  0.55
1982 Gorman CM, Merlino GT, Willingham MC, Pastan I, Howard BH. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection Proceedings of the National Academy of Sciences of the United States of America. 79: 6777-6781. PMID 6294651 DOI: 10.1073/pnas.79.22.6777  0.332
1982 Horiuchi R, Johnson ML, Willingham MC, Pastan I, Cheng S. Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 5527-31. PMID 6291049 DOI: 10.1073/pnas.79.18.5527  0.315
1982 Pastan IH, Willingham M, de Crombrugghe B, Gottesman MM. Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity. National Cancer Institute Monograph. 60: 7-15. PMID 6289108  0.452
1982 Merlino GT, Tyagi JS, de Crombrugghe B, Pastan I. Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts. The Journal of Biological Chemistry. 257: 7254-61. PMID 6282836  0.533
1981 Pretorius HT, Nandi PK, Lippoldt RE, Johnson ML, Keen JH, Pastan I, Edelhoch H. Molecular characterization of human clathrin. Biochemistry. 20: 2777-82. PMID 7248247 DOI: 10.1021/Bi00513A011  0.549
1981 Vogeli G, Ohkubo H, Avvedimento VE, Sullivan M, Yamada Y, Mudryj M, Pastan I, de Crombrugghe B. A repetitive structure in the chick alpha 2-collagen gene. Cold Spring Harbor Symposia On Quantitative Biology. 45: 777-83. PMID 6942950 DOI: 10.1101/Sqb.1981.045.01.096  0.531
1981 Merlino GT, Vogeli G, Yamamoto T, de Crombrugghe B, Pastan I. Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene. The Journal of Biological Chemistry. 256: 11251-8. PMID 6270147  0.519
1981 Dickson LA, Ninomiya Y, Bernard MP, Pesciotta DM, Parsons J, Green G, Eikenberry EF, de Crombrugghe B, Vogeli G, Pastan I, Fietzek PP, Olsen BR. The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene. The Journal of Biological Chemistry. 256: 8407-15. PMID 6267043  0.486
1981 Sobel ME, Yamamoto T, De Crombrugghe B, Pastan I. Regulation of procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts Biochemistry. 20: 2678-2684. PMID 6263317 DOI: 10.1021/Bi00512A049  0.554
1981 Fagan JB, Sobel ME, Yamada KM, de Crombrugghe B, Pastan I. Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA Journal of Biological Chemistry. 256: 520-525. PMID 6256355  0.474
1981 Maxfield FR, Willingham MC, Pastan I, Dragsten P, Cheng SY. Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. Science (New York, N.Y.). 211: 63-5. PMID 6255563  0.479
1981 Maxfield FR, Willingham MC, Haigler HT, Dragsten P, Pastan IH. Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. Biochemistry. 20: 5353-8. PMID 6170323 DOI: 10.1021/Bi00521A041  0.487
1980 Yamada Y, Avvedimento VE, Mudryj M, Ohkubo H, Vogeli G, Irani M, Pastan I, de Crombrugghe B. The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell. 22: 887-92. PMID 7460017 DOI: 10.1016/0092-8674(80)90565-6  0.544
1980 Vogeli G, Avvedimento EV, Sullivan M, Maizel JV, Lozano G, Adams SL, Pastan I, de Crombrugghe B. Isolation and characterization of genomic DNA coding for α2 type I collagen Nucleic Acids Research. 8: 1823-1837. PMID 7433131 DOI: 10.1093/Nar/8.8.1823  0.544
1980 Haigler HT, Willingham MC, Pastan I. Inhibitors of 125I-epidermal growth factor internalization Biochemical and Biophysical Research Communications. 94: 630-637. PMID 6967318 DOI: 10.1016/0006-291X(80)91279-6  0.323
1980 Ohkubo H, Vogeli G, Mudryj M, Avvedimento VE, Sullivan M, Pastan I, de Crombrugghe B. Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 7059-63. PMID 6452631 DOI: 10.1073/Pnas.77.12.7059  0.557
1980 Yamamoto T, de Crombrugghe B, Pastan I. Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell. 22: 787-97. PMID 6257399 DOI: 10.1016/0092-8674(80)90555-3  0.553
1980 Yamamoto T, Sobel ME, Adams SL, Avvedimento VE, DiLauro R, Pastan I, de Crombrugghe B, Showalter A, Pesciotta D, Fietzek P, Olsen B. Construction of a recombinant bacterial plasmid containing pro-α1(I) collagen DNA sequences Journal of Biological Chemistry. 255: 2612-2615. PMID 6244285  0.474
1980 Haigler HT, Maxfield FR, Willingham MC, Pastan I. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. The Journal of Biological Chemistry. 255: 1239-41. PMID 6243633  0.506
1980 Willingham MC, Maxfield FR, Pastan I. Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 28: 818-23. PMID 6160180 DOI: 10.1177/28.8.6160180  0.554
1980 Avvedimento VE, Vogeli G, Yamada Y, Maizel JV, Pastan I, de Crombrugghe B. Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell. 21: 689-96. PMID 6159982 DOI: 10.1016/0092-8674(80)90432-8  0.543
1980 Cheng SY, Maxfield FR, Robbins J, Willingham MC, Pastan IH. Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 77: 3425-9. PMID 6158047 DOI: 10.1073/Pnas.77.6.3425  0.488
1980 Davies PJ, Davies DR, Levitzki A, Maxfield FR, Milhaud P, Willingham MC, Pastan IH. Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature. 283: 162-7. PMID 6153122 DOI: 10.1038/283162A0  0.48
1979 Fagan JB, Yamada KM, de Crombrugghe B, Pastan I. Partial purification and characterization of the messenger RNA for cell fibronectin. Nucleic Acids Research. 6: 3471-80. PMID 573888 DOI: 10.1093/nar/6.11.3471  0.619
1979 Yamada KM, Olden K, Pastan I. Transformation-sensitive cell surface protein: isolation, characterization, and role in cellular morphology and adhesion. Annals of the New York Academy of Sciences. 312: 256-77. PMID 291364 DOI: 10.1111/j.1749-6632.1978.tb16807.x  0.516
1979 LeCam A, Maxfield F, Willingham M, Pastan I. Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization. Biochemical and Biophysical Research Communications. 88: 873-81. PMID 223575 DOI: 10.1016/0006-291X(79)91490-6  0.516
1979 Willingham MC, Maxfield FR, Pastan IH. alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions. The Journal of Cell Biology. 82: 614-25. PMID 92473 DOI: 10.1083/Jcb.82.3.614  0.484
1979 Maxfield FR, Willingham MC, Davies PJ, Pastan I. Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface. Nature. 277: 661-3. PMID 85262 DOI: 10.1038/277661A0  0.539
1979 Maxfield FR, Davies PJ, Klempner L, Willingham MC, Pastan I. Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proceedings of the National Academy of Sciences of the United States of America. 76: 5731-5. PMID 42903 DOI: 10.1073/Pnas.76.11.5731  0.547
1978 Yamada KM, Schlesinger DH, Kennedy DW, Pastan I. Characterization of a major fibroblast cell surface glycoprotein. Biochemistry. 16: 5552-9. PMID 562674 DOI: 10.1021/bi00644a025  0.477
1978 Sobel ME, Yamamoto T, Adams SL, DiLauro R, Avvedimento VE, de Crombrugghe B, Pastan I. Construction of a recombinant bacterial plasmid containing a chick pro-α2 collagen gene sequence Proceedings of the National Academy of Sciences of the United States of America. 75: 5846-5850. PMID 366605 DOI: 10.1073/Pnas.75.12.5846  0.556
1978 Pratt RM, Pastan I. Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis. Nature. 272: 68-70. PMID 305006 DOI: 10.1038/272068A0  0.338
1978 Maxfield FR, Schlessinger J, Shechter Y, Pastan I, Willingham MC. Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell. 14: 805-10. PMID 80283 DOI: 10.1016/0092-8674(78)90336-7  0.545
1978 Howard BH, Adams SL, Sobel ME, Pastan I, de Crombrugghe B. Decreased levels of collagen mRNA in Rous sarcoma virus-transformed chick embryo fibroblasts Journal of Biological Chemistry. 253: 5869-5874. PMID 78927  0.508
1977 Willingham MC, Yamada KM, Yamada SS, Pouysségur J, Pastan I. Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell. 10: 375-80. PMID 557370 DOI: 10.1016/0092-8674(77)90024-1  0.487
1977 Schlessinger J, Barak LS, Hammes GG, Yamada KM, Pastan I, Webb WW, Elson EL. Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components. Proceedings of the National Academy of Sciences of the United States of America. 74: 2909-13. PMID 331320 DOI: 10.1073/Pnas.74.7.2909  0.494
1977 Yamada KM, Yamada SS, Pastan I. Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines. The Journal of Cell Biology. 74: 649-54. PMID 328519 DOI: 10.1083/jcb.74.2.649  0.497
1977 Adams SL, Sobel ME, Howard BH, Olden K, Yamada KM, de Crombrugghe B, Pastan I. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus transformed chick embryo fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 74: 3399-3403. PMID 198783 DOI: 10.1073/pnas.74.8.3399  0.645
1977 Yamada KM, Pastan I. The relationship between cell surface protein and glucose and alpha-aminoisobutyrate transport in transformed chick and mouse cells. Journal of Cellular Physiology. 89: 827-9. PMID 188852 DOI: 10.1002/jcp.1040890450  0.483
1976 Yamada KM, Yamada SS, Pastan I. The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. Proceedings of the National Academy of Sciences of the United States of America. 72: 3158-62. PMID 1059102 DOI: 10.1073/pnas.72.8.3158  0.505
1976 Thomopoulos P, Roth J, Lovelace E, Pastan I. Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation Cell. 8: 417-423. PMID 954096 DOI: 10.1016/0092-8674(76)90154-9  0.348
1976 Yamada KM, Yamada SS, Pastan I. Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 73: 1217-21. PMID 177979 DOI: 10.1073/pnas.73.4.1217  0.495
1976 Yamada KM, Ohanian SH, Pastan I. Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells. Cell. 9: 241-5. PMID 61821 DOI: 10.1016/0092-8674(76)90115-X  0.49
1974 Musso RE, de Crombrugghe B, Pastan I, Sklar J, Yot P, Weissman S. The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 71: 4940-4. PMID 4612533 DOI: 10.1073/pnas.71.12.4940  0.512
1973 De Crombrugghe B, Pastan I. Regulation of gene expression by cyclic AMP in Escherichia coli. Symposia of the Society For Experimental Biology. 27: 365-9. PMID 4358368  0.476
1973 De Crombrugghe B, Pastan I, Shaw WV, Rosner JL. Stimulation by cyclic AMP and ppGpp of chloramphenicol acetyl transferase synthesis. Nature: New Biology. 241: 237-9. PMID 4349357 DOI: 10.1038/newbio241237a0  0.535
1973 De Crombrugghe B, Adhya S, Gottesman M, Pastan I. Effect of Rho on transcription of bacterial operons. Nature: New Biology. 241: 260-4. PMID 4348358 DOI: 10.1038/Newbio241260A0  0.532
1972 Stadtman ER, Stadtman TC, Pastan I, Smith LD. Clostridium barkeri sp. n. Journal of Bacteriology. 110: 758-60. PMID 4553843 DOI: 10.1128/Jb.110.2.758-760.1972  0.381
1972 Pastan I, De Crombrugghe B. Control of expression of genetic information in E. coli by cyclic AMP. Acta Endocrinologica. Supplementum. 168: 298-306. PMID 4342943 DOI: 10.1530/acta.0.071s298  0.501
1972 Johnson GS, Pastan I. N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells Nature: New Biology. 237: 267-268. PMID 4338725 DOI: 10.1038/NEWBIO237267A0  0.307
1972 D'Armiento M, Johnson GS, Pastan I. Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 ) Proceedings of the National Academy of Sciences of the United States of America. 69: 459-462. PMID 4333987 DOI: 10.1073/Pnas.69.2.459  0.307
1971 Pastan I, Perlman RL, Emmer M, Varmus HE, DeCrombrugghe B, Chen BP, Parks J. Regulation of gene expression in Escherichia coli by cyclic AMP. Recent Progress in Hormone Research. 27: 421-32. PMID 4336400 DOI: 10.1016/B978-0-12-571127-2.50034-1  0.509
1971 Lefkowitz RJ, Roth J, Pastan I. ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. Annals of the New York Academy of Sciences. 185: 195-209. PMID 4330491 DOI: 10.1111/J.1749-6632.1971.Tb45249.X  0.472
1971 Johnson GS, Pastan I. Change in growth and morphology of fibroblasts by prostaglandins Journal of the National Cancer Institute. 47: 1357-1364. PMID 4330467 DOI: 10.1093/jnci/47.6.1357  0.305
1971 Chen B, de Crombrugghe B, Anderson WB, Gottesman ME, Pastan I, Perlman RL. On the mechanism of action of lac repressor. Nature: New Biology. 233: 67-70. PMID 4330295 DOI: 10.1038/newbio233067a0  0.537
1971 De Crombrugghe B, Chen B, Anderson W, Nissley P, Gottesman M, Pastan I, Perlman R. Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription. Nature: New Biology. 231: 139-42. PMID 4326354 DOI: 10.1038/newbio231139a0  0.566
1971 Miller Z, Varmus HE, Parks JS, Perlman RL, Pastan I. Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. The Journal of Biological Chemistry. 246: 2898-903. PMID 4324343  0.399
1971 Varmus HE, Perlman RL, Pastan I. Regulation of lac transcription in antibiotic-treated E. coli. Nature: New Biology. 230: 41-4. PMID 4324113 DOI: 10.1038/Newbio230041A0  0.477
1971 De Crombrugghe B, Chen B, Gottesman M, Pastan I, Varmus HE, Emmer M, Perlman RL. Regulation of lac mRNA synthesis in a soluble cell-free system. Nature: New Biology. 230: 37-40. PMID 4324112 DOI: 10.1038/Newbio230037A0  0.645
1971 Johnson GS, Friedman RM, Pastan I. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. Proceedings of the National Academy of Sciences of the United States of America. 68: 425-9. PMID 4322609 DOI: 10.1073/Pnas.68.2.425  0.313
1970 Varmus HE, Perlman RL, Pastan I. Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. The Journal of Biological Chemistry. 245: 6366-72. PMID 4320837  0.394
1970 Lefkowitz RJ, Roth J, Pastan I. Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. Nature. 228: 864-6. PMID 4320054 DOI: 10.1038/228864A0  0.471
1970 Lefkowitz RJ, Roth J, Pastan I. Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma. Science (New York, N.Y.). 170: 633-5. PMID 4319388 DOI: 10.1126/Science.170.3958.633  0.487
1970 Lefkowitz RJ, Roth J, Pricer W, Pastan I. ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 65: 745-52. PMID 4315615 DOI: 10.1073/Pnas.65.3.745  0.496
1970 Varmus HE, Perlman RL, Pastan I. Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. The Journal of Biological Chemistry. 245: 2259-67. PMID 4315149  0.375
1970 de Crombrugghe B, Varmus HE, Perlman RL, Pastan IH. Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. Biochemical and Biophysical Research Communications. 38: 894-901. PMID 4314384 DOI: 10.1016/0006-291X(70)90805-3  0.606
1970 Perlman R, Chen B, deCrombrugghe B, Emmer M, Gottesman M, Varmus H, Pastan I. The Regulation of lac Operon Transcription by Cyclic Adenosine 3', 5'-Monophosphate Cold Spring Harbor Symposia On Quantitative Biology. 35: 419-423. DOI: 10.1101/Sqb.1970.035.01.054  0.463
1969 De Crombrugghe B, Perlman RL, Varmus HE, Pastan I. Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. The Journal of Biological Chemistry. 244: 5828-35. PMID 4310825  0.578
1969 Perlman RL, De Crombrugghe B, Pastan I. Cyclic AMP regulates catabolite and transient repression in E. coli Nature. 223: 810-812. PMID 4307969 DOI: 10.1038/223810a0  0.532
1969 Levey GS, Roth J, Pastan I. Effect of propranolol and phentolamine on canine and bovine responses to TSH Endocrinology. 84: 1009-1015. PMID 4304995 DOI: 10.1210/ENDO-84-5-1009  0.325
1969 Roth J, Gorden P, Pastan I. "Big insulin": a new component of plasma insulin detected by immunoassay. Proceedings of the National Academy of Sciences of the United States of America. 61: 138-45. PMID 4301586 DOI: 10.1073/Pnas.61.1.138  0.348
1967 Taunton OD, Roth J, Pastan I. ACTH stimulation of adenyl cyclase in adrenal homogenates. Biochemical and Biophysical Research Communications. 29: 1-7. PMID 4293391 DOI: 10.1016/0006-291X(67)90531-1  0.347
1966 Tsai L, Pastan I, Stadtman ER. Nicotinic acid metabolism. II. The isolation and characterization of intermediates in the fermentation of nicotinic acid. The Journal of Biological Chemistry. 241: 1807-13. PMID 5945854  0.431
1966 Jakoby WB, Labaw L, Edelhoch H, Pastan I, Rall JE. Thyroglobulin: evidence for crystallization and association. Science (New York, N.Y.). 153: 1671-2. PMID 5917084 DOI: 10.1126/Science.153.3744.1671  0.52
1964 PASTAN I, TSAI L, STADTMAN ER. NICOTINIC ACID METABOLISM. I. DISTRIBUTION OF ISOTOPE IN FERMENTATION PRODUCTS OF LABELLED NICOTINIC ACID. The Journal of Biological Chemistry. 239: 902-6. PMID 14157025  0.431
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