David J. Craik - Publications

Affiliations: 
IMB University of Queensland, Saint Lucia, Queensland, Australia 

168 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Jakob V, Zoller BGE, Rinkes J, Wu Y, Kiefer AF, Hust M, Polten S, White AM, Harvey PJ, Durek T, Craik DJ, Siebert A, Kazmaier U, Empting M. Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry. 231: 114148. PMID 35114538 DOI: 10.1016/j.ejmech.2022.114148  0.317
2021 Tran HNT, Tran P, Deuis JR, McMahon KL, Yap K, Craik DJ, Vetter I, Schroeder CI. Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides. Bioconjugate Chemistry. PMID 34751572 DOI: 10.1021/acs.bioconjchem.1c00452  0.32
2021 Yousuf A, Wu X, Bony AR, Sadeghi M, Huang YH, Craik DJ, Adams DJ. ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (Ca 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABA receptor activation. Journal of Neurochemistry. PMID 34738241 DOI: 10.1111/jnc.15535  0.356
2021 Hellinger R, Muratspahić E, Devi S, Koehbach J, Vasileva M, Harvey PJ, Craik DJ, Gründemann C, Gruber CW. Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides. Acs Chemical Biology. 16: 2373-2386. PMID 34592097 DOI: 10.1021/acschembio.1c00524  0.323
2021 Koehbach J, Gani J, Hilpert K, Craik DJ. Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens. Microorganisms. 9. PMID 34201398 DOI: 10.3390/microorganisms9061249  0.309
2021 Yap K, Du J, Rehm FBH, Tang SR, Zhou Y, Xie J, Wang CK, de Veer SJ, Lua LHL, Durek T, Craik DJ. Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols. PMID 33597770 DOI: 10.1038/s41596-020-00483-0  0.324
2021 Dang TT, Chan LY, Tombling BJ, Harvey PJ, Gilding EK, Craik DJ. In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from . Journal of Natural Products. PMID 33570395 DOI: 10.1021/acs.jnatprod.0c01065  0.338
2021 Pinto MEF, Chan LY, Koehbach J, Devi S, Gründemann C, Gruber CW, Gomes M, Bolzani VS, Cilli EM, Craik DJ. Cyclotides from Brazilian and Their Effects on Human Lymphocytes. Journal of Natural Products. PMID 33397096 DOI: 10.1021/acs.jnatprod.0c01069  0.308
2020 Tombling BJ, Lammi C, Lawrence N, Gilding EK, Grazioso G, Craik DJ, Wang CK. Bioactive Cyclization Optimizes the Affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Peptide Inhibitor. Journal of Medicinal Chemistry. PMID 33356222 DOI: 10.1021/acs.jmedchem.0c01766  0.327
2020 Jackson MA, Nguyen LTT, Gilding EK, Durek T, Craik DJ. Make it or break it: Plant AEPs on stage in biotechnology. Biotechnology Advances. 107651. PMID 33141031 DOI: 10.1016/j.biotechadv.2020.107651  0.301
2020 de Veer SJ, White AM, Craik D. Sunflower Trypsin Inhibitor-1 (SFTI-1): Sowing Seeds in the Fields of Chemistry and Biology. Angewandte Chemie (International Ed. in English). PMID 32621554 DOI: 10.1002/Anie.202006919  0.315
2020 White A, de Veer S, Wu G, Harvey P, Yap K, King GJ, Swedberg JE, Wang CK, Law RHP, Durek T, Craik D. Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angewandte Chemie (International Ed. in English). PMID 32270580 DOI: 10.1002/Anie.202003435  0.324
2020 Kan M, Craik DJ. Discovery of cyclotides from Australasian plants Australian Journal of Chemistry. 73: 287-299. DOI: 10.1071/Ch19658  0.305
2020 Yap K, Du J, Looi FY, Tang SR, Veer SJd, Bony AR, Rehm FBH, Xie J, Chan LY, Wang CK, Adams DJ, Lua LHL, Durek T, Craik DJ. An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides Green Chemistry. 22: 5002-5016. DOI: 10.1039/D0Gc01366H  0.462
2019 de Veer SJ, Kan MW, Craik DJ. Cyclotides: From Structure to Function. Chemical Reviews. PMID 31829013 DOI: 10.1021/Acs.Chemrev.9B00402  0.329
2019 Vernen F, Harvey PJ, Dias SA, Veiga AS, Huang YH, Craik DJ, Lawrence N, Troeira Henriques S. Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. International Journal of Molecular Sciences. 20. PMID 31455019 DOI: 10.3390/Ijms20174184  0.308
2019 Koehbach J, Craik DJ. The Vast Structural Diversity of Antimicrobial Peptides. Trends in Pharmacological Sciences. 40: 517-528. PMID 31230616 DOI: 10.1016/J.Tips.2019.04.012  0.306
2019 El Hamdaoui Y, Wu X, Clark RJ, Giribaldi J, Anangi R, Craik DJ, King GF, Dutertre S, Kaas Q, Herzig V, Nicke A. Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Frontiers in Pharmacology. 10: 577. PMID 31214027 DOI: 10.3389/Fphar.2019.00577  0.34
2019 Oguis GK, Gilding EK, Jackson MA, Craik DJ. Butterfly Pea (), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine. Frontiers in Plant Science. 10: 645. PMID 31191573 DOI: 10.3389/Fpls.2019.00645  0.308
2019 Jackson MA, Yap K, Poth AG, Gilding EK, Swedberg JE, Poon S, Qu H, Durek T, Harris K, Anderson MA, Craik DJ. Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide. Frontiers in Plant Science. 10: 602. PMID 31156672 DOI: 10.3389/Fpls.2019.00602  0.314
2019 Yu R, Tae HS, Xu Q, Craik DJ, Adams DJ, Jiang T, Kaas Q. Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British Journal of Pharmacology. PMID 31062355 DOI: 10.1111/Bph.14698  0.309
2019 Du J, Chan LY, Poth AG, Craik DJ. Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. Journal of Natural Products. PMID 30673219 DOI: 10.1021/Acs.Jnatprod.8B00716  0.32
2018 Harvey PJ, Kurniawan ND, Finol-Urdaneta RK, McArthur JR, Van Lysebetten D, Dash TS, Hill JM, Adams DJ, Durek T, Craik DJ. NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency. Molecules (Basel, Switzerland). 23. PMID 30360356 DOI: 10.3390/Molecules23102715  0.452
2018 Wu X, Tae HS, Huang YH, Adams DJ, Craik DJ, Kaas Q. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology. PMID 30009767 DOI: 10.1016/J.Bcp.2018.07.007  0.376
2018 Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O'Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ. Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. Acs Chemical Biology. PMID 29746088 DOI: 10.1021/Acschembio.8B00190  0.408
2017 Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology. PMID 29194563 DOI: 10.1111/Bph.14115  0.321
2017 Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI. Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific Reports. 7: 16606. PMID 29192197 DOI: 10.1038/S41598-017-16809-0  0.321
2017 Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. The Journal of Biological Chemistry. PMID 28851841 DOI: 10.1074/jbc.M117.808386  0.407
2017 Craik DJ, Lee MH, Rehm FBH, Tombling B, Doffek B, Peacock H. Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds. Bioorganic & Medicinal Chemistry. PMID 28818463 DOI: 10.1016/J.Bmc.2017.08.005  0.312
2017 de Veer SJ, Weidmann J, Craik DJ. Cyclotides as Tools in Chemical Biology. Accounts of Chemical Research. 50: 1557-1565. PMID 28644007 DOI: 10.1021/Acs.Accounts.7B00157  0.35
2017 Qu H, Smithies BJ, Durek T, Craik DJ. Synthesis and protein engineering applications of cyclotides Australian Journal of Chemistry. 70: 152-161. DOI: 10.1071/Ch16589  0.306
2016 White AM, Craik DJ. Discovery and Optimization of Peptide Macrocycles. Expert Opinion On Drug Discovery. PMID 27718641 DOI: 10.1080/17460441.2016.1245720  0.31
2016 Elliott AG, Franke B, Armstrong DA, Craik DJ, Mylne JS, Rosengren KJ. Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids. PMID 27695949 DOI: 10.1007/S00726-016-2333-X  0.356
2016 Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, ... ... Craik DJ, et al. Accurate de novo design of hyperstable constrained peptides. Nature. PMID 27626386 DOI: 10.1038/Nature19791  0.325
2016 Craik DJ, Shim YY, Göransson U, Moss GP, Tan N, Jadhav PD, Shen J, Reaney MJ. Nomenclature of Homodetic Cyclic Peptides Produced from Ribosomal Precursors: An IUPAC Task Group Interim Report. Biopolymers. PMID 27554762 DOI: 10.1002/Bip.22939  0.617
2016 Niyomploy P, Chan LY, Poth AG, Colgrave ML, Sangvanich P, Craik DJ. Discovery, isolation and structural characterization of cyclotides from Viola sumatrana Miq. Biopolymers. PMID 27403748 DOI: 10.1002/Bip.22914  0.302
2016 Kwon S, Bosmans F, Kaas Q, Cheneval O, Conibear AC, Rosengren KJ, Wang CK, Schroeder CI, Craik DJ. Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering. PMID 27093300 DOI: 10.1002/Bit.25993  0.323
2016 Carstens BB, Swedberg J, Berecki G, Adams DJ, Craik DJ, Clark RJ. Effects of linker sequence modifications on the structure, stability and biological activity of a cyclic α-conotoxin. Biopolymers. PMID 27038328 DOI: 10.1002/Bip.22848  0.479
2016 Carstens BB, Berecki G, Daniel JT, Lee HS, Jackson KA, Tae HS, Sadeghi M, Castro J, O'Donnell T, Deiteren A, Brierley SM, Craik DJ, Adams DJ, Clark RJ. Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie (International Ed. in English). PMID 26948522 DOI: 10.1002/Anie.201600297  0.467
2016 Castro J, Harrington AM, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM. α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut. PMID 26887818 DOI: 10.1136/Gutjnl-2015-310971  0.354
2016 Huang YH, Henriques ST, Lawrence N, Kaas Q, Craik DJ. Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562 Journal of Peptide Science. 22. DOI: 10.1002/Psc.2950  0.59
2015 Burman R, Yeshak MY, Larsson S, Craik DJ, Rosengren KJ, Göransson U. Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science. 6: 855. PMID 26579135 DOI: 10.3389/Fpls.2015.00855  0.581
2015 Conibear AC, Chaousis S, Durek T, Rosengren KJ, Craik DJ, Schroeder CI. Approaches to the stabilisation of bioactive epitopes by grafting and peptide cyclisation. Biopolymers. PMID 26566734 DOI: 10.1002/Bip.22767  0.319
2015 Yu R, Seymour VA, Berecki G, Jia X, Akcan M, Adams DJ, Kaas Q, Craik DJ. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports. 5: 13264. PMID 26290113 DOI: 10.1038/Srep13264  0.413
2015 Akcan M, Clark RJ, Daly NL, Conibear AC, de Faoite A, Heghinian MD, Sahil T, Adams DJ, Marí F, Craik DJ. Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers. PMID 26172377 DOI: 10.1002/Bip.22699  0.484
2015 Wang CK, Northfield SE, Swedberg JE, Colless B, Chaousis S, Price DA, Liras S, Craik DJ. Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability. European Journal of Medicinal Chemistry. 97: 202-13. PMID 25974856 DOI: 10.1016/J.Ejmech.2015.04.049  0.31
2015 Mahatmanto T, Mylne JS, Poth AG, Swedberg JE, Kaas Q, Schaefer H, Craik DJ. The evolution of Momordica cyclic peptides. Molecular Biology and Evolution. 32: 392-405. PMID 25376175 DOI: 10.1093/Molbev/Msu307  0.314
2014 Elliott AG, Delay C, Liu H, Phua Z, Rosengren KJ, Benfield AH, Panero JL, Colgrave ML, Jayasena AS, Dunse KM, Anderson MA, Schilling EE, Ortiz-Barrientos D, Craik DJ, Mylne JS. Evolutionary origins of a bioactive peptide buried within Preproalbumin. The Plant Cell. 26: 981-95. PMID 24681618 DOI: 10.1105/Tpc.114.123620  0.324
2014 Berecki G, Daly NL, Huang YH, Vink S, Craik DJ, Alewood PF, Adams DJ. Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. British Journal of Pharmacology. 171: 3313-27. PMID 24628243 DOI: 10.1111/Bph.12686  0.318
2014 Jia X, Kwon S, Wang CI, Huang YH, Chan LY, Tan CC, Rosengren KJ, Mulvenna JP, Schroeder CI, Craik DJ. Semienzymatic cyclization of disulfide-rich peptides using Sortase A. The Journal of Biological Chemistry. 289: 6627-38. PMID 24425873 DOI: 10.1074/Jbc.M113.539262  0.329
2014 Conibear AC, Bochen A, Rosengren KJ, Stupar P, Wang C, Kessler H, Craik DJ. The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif. Chembiochem : a European Journal of Chemical Biology. 15: 451-9. PMID 24382674 DOI: 10.1002/Cbic.201300568  0.302
2014 Harrington AM, Castro J, Garcia-Caraballo S, Maddern J, Craik D, Adams DJ, Brierley SM. 888 α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain Gastroenterology. 146: S-156. DOI: 10.1016/S0016-5085(14)60555-2  0.321
2014 Taylor CM, Northfield SE, Wang CK, Craik DJ. Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1 Tetrahedron. 70: 7669-7674. DOI: 10.1016/J.Tet.2014.06.058  0.309
2013 Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America. 110: 21183-8. PMID 24248349 DOI: 10.1073/Pnas.1311183110  0.636
2013 He WJ, Chan LY, Clark RJ, Tang J, Zeng GZ, Franco OL, Cantacessi C, Craik DJ, Daly NL, Tan NH. Novel inhibitor cystine knot peptides from Momordica charantia. Plos One. 8: e75334. PMID 24116036 DOI: 10.1371/Journal.Pone.0075334  0.337
2013 Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 34428-42. PMID 24100032 DOI: 10.1074/Jbc.M113.512582  0.37
2013 Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/J.Bcp.2013.07.016  0.383
2013 Gerlach SL, Göransson U, Kaas Q, Craik DJ, Mondal D, Gruber CW. A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis. Biopolymers. 100: 433-7. PMID 23907794 DOI: 10.1002/Bip.22258  0.594
2013 Craik DJ. Joseph Rudinger memorial lecture: discovery and applications of cyclotides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 19: 393-407. PMID 23737440 DOI: 10.1002/Psc.2523  0.301
2013 Yu R, Kompella SN, Adams DJ, Craik DJ, Kaas Q. Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 56: 3557-67. PMID 23566299 DOI: 10.1021/Jm400041H  0.34
2013 Conibear AC, Rosengren KJ, Daly NL, Henriques ST, Craik DJ. The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity. The Journal of Biological Chemistry. 288: 10830-40. PMID 23430740 DOI: 10.1074/Jbc.M113.451047  0.331
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.574
2013 Chan LY, He W, Tan N, Zeng G, Craik DJ, Daly NL. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides. 39: 29-35. PMID 23127518 DOI: 10.1016/J.Peptides.2012.09.018  0.313
2013 Adams DJ, Berecki G, Clark R, Craik DJ. Development of analgesic alpha-conotoxins for treatment of chronic pain Clinical and Experimental Pharmacology and Physiology. 40: 4-4. DOI: 10.1111/1440-1681.12170  0.321
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.531
2012 Craik DJ, Henriques ST, Mylne JS, Wang CK. Cyclotide isolation and characterization. Methods in Enzymology. 516: 37-62. PMID 23034223 DOI: 10.1016/B978-0-12-394291-3.00024-1  0.326
2012 Eliasen R, Daly NL, Wulff BS, Andresen TL, Conde-Frieboes KW, Craik DJ. Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. The Journal of Biological Chemistry. 287: 40493-501. PMID 23012369 DOI: 10.1074/Jbc.M112.395442  0.303
2012 Cemazar M, Kwon S, Mahatmanto T, Ravipati AS, Craik DJ. Discovery and applications of disulfide-rich cyclic peptides. Current Topics in Medicinal Chemistry. 12: 1534-45. PMID 22827522 DOI: 10.2174/156802612802652484  0.334
2012 Craik DJ, Swedberg JE, Mylne JS, Cemazar M. Cyclotides as a basis for drug design. Expert Opinion On Drug Discovery. 7: 179-94. PMID 22468950 DOI: 10.1517/17460441.2012.661554  0.309
2012 Andersson HS, Figueredo SM, Haugaard-Kedström LM, Bengtsson E, Daly NL, Qu X, Craik DJ, Ouellette AJ, Rosengren KJ. The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids. 43: 1471-83. PMID 22286872 DOI: 10.1007/S00726-012-1220-3  0.311
2012 Clark RJ, Craik DJ. Engineering cyclic peptide toxins Methods in Enzymology. 503: 57-74. PMID 22230565 DOI: 10.1016/B978-0-12-396962-0.00003-3  0.325
2012 Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochemical Pharmacology. 83: 419-26. PMID 22108175 DOI: 10.1016/J.Bcp.2011.11.006  0.354
2012 Pinto MFS, Fensterseifer ICM, Migliolo L, Sousa DA, De Capdville G, Arboleda-Valencia JW, Colgrave ML, Craik DJ, Magalhães BS, Dias SC, Franco OL. Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane Journal of Biological Chemistry. 287: 134-147. PMID 22074926 DOI: 10.1074/Jbc.M111.294009  0.313
2012 Franco A, Heighinian M, Mejia M, McCall J, Nag S, Akondi K, Melaun C, Daly N, Luetje CW, Alewood PF, Craik DJ, Godenschwege T, Adams DJ, Marí F. 105. Discovery, Characterization, and Functional Implications of Conotoxins from Cone Snails Species of the Americas Toxicon. 60: 148. DOI: 10.1016/J.Toxicon.2012.04.106  0.321
2011 Chan LY, Gunasekera S, Henriques ST, Worth NF, Le SJ, Clark RJ, Campbell JH, Craik DJ, Daly NL. Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood. 118: 6709-17. PMID 22039263 DOI: 10.1182/Blood-2011-06-359141  0.321
2011 Smith AB, Daly NL, Craik DJ. Cyclotides: a patent review. Expert Opinion On Therapeutic Patents. 21: 1657-72. PMID 22017409 DOI: 10.1517/13543776.2011.620606  0.313
2011 Halai R, Callaghan B, Daly NL, Clark RJ, Adams DJ, Craik DJ. Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA B receptor Journal of Medicinal Chemistry. 54: 6984-6992. PMID 21888386 DOI: 10.1021/Jm201060R  0.436
2011 He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N. Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides. 32: 1719-23. PMID 21723349 DOI: 10.1016/J.Peptides.2011.06.016  0.34
2011 de Araujo AD, Callaghan B, Nevin ST, Daly NL, Craik DJ, Moretta M, Hopping G, Christie MJ, Adams DJ, Alewood PF. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Ed. in English). 50: 6527-9. PMID 21630402 DOI: 10.1002/Anie.201101642  0.398
2011 Craik DJ, Conibear AC. The chemistry of cyclotides Journal of Organic Chemistry. 76: 4805-4817. PMID 21526790 DOI: 10.1021/Jo200520V  0.321
2011 Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry & Biology. 18: 336-43. PMID 21439478 DOI: 10.1002/Psc.2448  0.541
2011 Haugaard-Kedström LM, Shabanpoor F, Hossain MA, Clark RJ, Ryan PJ, Craik DJ, Gundlach AL, Wade JD, Bathgate RA, Rosengren KJ. Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society. 133: 4965-74. PMID 21384867 DOI: 10.1021/Ja110567J  0.3
2011 Daly NL, Rosengren KJ, Troeira Henriques S, Craik DJ. NMR and protein structure in drug design: Application to cyclotides and conotoxins European Biophysics Journal. 40: 359-370. PMID 21290122 DOI: 10.1007/S00249-011-0672-9  0.304
2011 Daly NL, Callaghan B, Clark RJ, Nevin ST, Adams DJ, Craik DJ. Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Journal of Biological Chemistry. 286: 10233-10237. PMID 21252227 DOI: 10.1074/Jbc.M110.196170  0.367
2011 Lovelace ES, Gunasekera S, Alvarmo C, Clark RJ, Nevin ST, Grishin AA, Adams DJ, Craik DJ, Daly NL. Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization Antioxidants and Redox Signaling. 14: 87-95. PMID 20486767 DOI: 10.1089/Ars.2009.3068  0.445
2011 Aboye TL, Clark RJ, Burman R, Roig MB, Craik DJ, Göransson U. Interlocking disulfides in circular proteins: Toward efficient oxidative folding of cyclotides Antioxidants and Redox Signaling. 14: 77-86. PMID 20486762 DOI: 10.1089/Ars.2010.3112  0.571
2011 Adams D, Grishin A, Hung A, Clark R, Akondi K, Alewood P, Craik D. Scanning mutagenesis of α-conotoxin AuIB reveals a critical residue for activity at the α3β4 nicotinic acetylcholine receptor Biochemical Pharmacology. 82: 1028. DOI: 10.1016/J.Bcp.2011.07.017  0.321
2011 Conibear AC, Craik DJ. Chemical synthesis of naturally-occurring cyclic mini-proteins from plants and animals Israel Journal of Chemistry. 51: 908-916. DOI: 10.1002/Ijch.201100067  0.317
2010 Ireland DC, Clark RJ, Daly NL, Craik DJ. Isolation, sequencing, and structure - Activity relationships of cyclotides Journal of Natural Products. 73: 1610-1622. PMID 20718473 DOI: 10.1021/Np1000413  0.305
2010 Clark RJ, Craik DJ. Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins Biopolymers. 94: 414-422. PMID 20593458 DOI: 10.1002/Bip.21372  0.342
2010 Colgrave ML, Korsinczky MJL, Clark RJ, Foley F, Craik DJ. Sunflower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs Biopolymers. 94: 665-672. PMID 20564016 DOI: 10.1002/Bip.21415  0.307
2010 Burman R, Svedlund E, Felth J, Hassan S, Herrmann A, Clark RJ, Craik DJ, Bohlin L, Claeson P, Göransson U, Gullbo J. Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice Biopolymers. 94: 626-634. PMID 20564012 DOI: 10.1002/Bip.21408  0.66
2010 Colgrave ML, Poth AG, Kaas Q, Craik DJ. A new "era" for cyclotide sequencing Biopolymers. 94: 592-601. PMID 20564007 DOI: 10.1002/Bip.21400  0.302
2010 Clark RJ, Jensen J, Nevin ST, Callaghan BP, Adams DJ, Craik DJ. The engineering of an orally active conotoxin for the treatment of neuropathic pain Angewandte Chemie - International Edition. 49: 6545-6548. PMID 20533477 DOI: 10.1002/Anie.201000620  0.411
2010 Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/Ja910602H  0.376
2010 Burman R, Gruber CW, Rizzardi K, Herrmann A, Craik DJ, Gupta MP, Göransson U. Cyclotide proteins and precursors from the genus Gloeospermum: Filling a blank spot in the cyclotide map of Violaceae Phytochemistry. 71: 13-20. PMID 19879608 DOI: 10.1016/J.Phytochem.2009.09.023  0.594
2010 Clark R, Guille V, Callaghan B, Adams D, Craik D. 167 DEVELOPMENT OF AN ORALLY ACTIVE PEPTIDE FOR THE TREATMENT OF NEUROPATHIC PAIN European Journal of Pain Supplements. 4: 50-50. DOI: 10.1016/S1754-3207(10)70172-3  0.321
2010 Clark R, Jensen J, Nevin S, Callaghan B, Adams D, Craik D. Inside Cover: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. Int. Ed. 37/2010) Angewandte Chemie International Edition. 49: 6460-6460. DOI: 10.1002/Anie.201003933  0.321
2010 Clark R, Jensen J, Nevin S, Callaghan B, Adams D, Craik D. Innentitelbild: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. 37/2010) Angewandte Chemie. 122: 6606-6606. DOI: 10.1002/Ange.201003933  0.321
2009 Chan LY, Wang CK, Major JM, Greenwood KP, Lewis RJ, Craik DJ, Daly NL. Isolation and characterization of peptides from Momordica cochinchinensis seeds. Journal of Natural Products. 72: 1453-8. PMID 19711988 DOI: 10.1021/Np900174N  0.329
2009 Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ. Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Journal of Biological Chemistry. 284: 20275-20284. PMID 19447885 DOI: 10.1074/Jbc.M109.015339  0.397
2009 Rosengren KJ, Bathgate RAD, Craik DJ, Daly NL, Haugaard‐Jönsson LM, Hossain MA, Wade JD. Structural Insights into the Function of Relaxins Annals of the New York Academy of Sciences. 1160: 20-26. PMID 19416153 DOI: 10.1111/J.1749-6632.2009.03833.X  0.314
2009 Wang CK, Hu SH, Martin JL, Sjögren T, Hajdu J, Bohlin L, Claeson P, Göransson U, Rosengren KJ, Tang J, Tan NH, Craik DJ. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. The Journal of Biological Chemistry. 284: 10672-83. PMID 19211551 DOI: 10.1074/Jbc.M900021200  0.728
2009 Haugaard-Jönsson LM, Hossain MA, Daly NL, Craik DJ, Wade JD, Rosengren KJ. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Biochemical Journal. 419: 619-627. PMID 19178384 DOI: 10.1042/Bj20082353  0.302
2009 Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/Jbc.M804950200  0.384
2009 Rosengren KJ, Daly NL, Craik DJ. NMR of peptide toxins Annual Reports On Nmr Spectroscopy. 68: 89-147. DOI: 10.1016/S0066-4103(09)06802-1  0.338
2009 Halai R, Clark R, Nevin S, Adams D, Craik D. Mutational atudies on alpha-conotoxin VCL1 Biopolymers. 92: 315-315. DOI: 10.1002/Bip.21223  0.321
2008 Gunasekera S, Foley FM, Clark RJ, Sando L, Fabri LJ, Craik DJ, Daly NL. Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. Journal of Medicinal Chemistry. 51: 7697-704. PMID 19053834 DOI: 10.1021/Jm800704E  0.316
2008 Callaghan B, Haythornthwaite A, Berecki G, Clark RJ, Craik DJ, Adams DJ. Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Journal of Neuroscience. 28: 10943-10951. PMID 18945902 DOI: 10.1523/Jneurosci.3594-08.2008  0.357
2008 Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/Jm800278K  0.366
2008 Imperial JS, Chen P, Sporning A, Terlau H, Daly NL, Craik DJ, Alewood PF, Olivera BM. Tyrosine-rich conopeptides affect voltage-gated K+ channels. The Journal of Biological Chemistry. 283: 23026-32. PMID 18505731 DOI: 10.1074/Jbc.M800084200  0.317
2008 Mylne JS, Craik DJ. 15N cyclotides by whole plant labeling Biopolymers. 90: 575-580. PMID 18464271 DOI: 10.1002/Bip.21012  0.322
2008 Simonsen SM, Sando L, Rosengren KJ, Wang CK, Colgrave ML, Daly NL, Craik DJ. Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity Journal of Biological Chemistry. 283: 9805-9813. PMID 18258598 DOI: 10.1074/Jbc.M709303200  0.306
2008 Clark RJ, Daly NL, Halai R, Nevin ST, Adams DJ, Craik DJ. The three-dimensional structure of the analgesic α-conotoxin, RgIA Febs Letters. 582: 597-602. PMID 18242183 DOI: 10.1016/J.Febslet.2008.01.027  0.358
2008 Herrmann A, Burman R, Mylne JS, Karlsson G, Gullbo J, Craik DJ, Clark RJ, Göransson U. The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry. 69: 939-52. PMID 18191970 DOI: 10.1016/J.Phytochem.2007.10.023  0.595
2008 Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ. Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. Journal of Natural Products. 71: 47-52. PMID 18081258 DOI: 10.1021/Np070393G  0.557
2008 Leta Aboye T, Clark RJ, Craik DJ, Göransson U. Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. Chembiochem : a European Journal of Chemical Biology. 9: 103-13. PMID 18058973 DOI: 10.1002/Cbic.200700357  0.531
2008 Ekberg J, Craik DJ, Adams DJ. Conotoxin modulation of voltage-gated sodium channels. The International Journal of Biochemistry & Cell Biology. 40: 2363-8. PMID 17951097 DOI: 10.1016/J.Biocel.2007.08.017  0.367
2008 Aboye TL, Clark RJ, Craik DJ, Goransson U. Synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. Planta Medica. 74: 1158-1158. DOI: 10.1055/S-0028-1084795  0.628
2008 Clark R, Tan CC, Nemeth E, Ganz T, Craik D. Understanding the structure/activity relationships of hepcidin Journal of Peptide Science. 14: 98-98. DOI: 10.1002/Psc.1090  0.531
2008 Aboye TL, Clark RJ, Craik DJ, Göransson U. Cover Picture: Ultra‐Stable Peptide Scaffolds for Protein Engineering—Synthesis and Folding of the Circular Cystine Knotted Cyclotide Cycloviolacin O2 (ChemBioChem 1/2008) Chembiochem. 9: 1-1. DOI: 10.1002/Cbic.200790068  0.531
2007 Nevin ST, Clark RJ, Klimis H, Christie MJ, Craik DJ, Adams DJ. Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology. 72: 1406-10. PMID 17804600 DOI: 10.1124/Mol.107.040568  0.371
2007 Craik DJ, Adams DJ. Chemical modification of conotoxins to improve stability and activity Acs Chemical Biology. 2: 457-468. PMID 17649970 DOI: 10.1021/Cb700091J  0.455
2007 Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ. The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides. Chembiochem : a European Journal of Chemical Biology. 8: 1001-11. PMID 17534989 DOI: 10.1002/Cbic.200700097  0.531
2007 Craik DJ, Clark RJ, Daly NL. Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins Expert Opinion On Investigational Drugs. 16: 595-604. PMID 17461734 DOI: 10.1517/13543784.16.5.595  0.317
2007 Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. Bmc Structural Biology. 7: 28. PMID 17445276 DOI: 10.1186/1472-6807-7-28  0.346
2006 Ireland DC, Colgrave ML, Craik DJ. A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability Biochemical Journal. 400: 1-12. PMID 16872274 DOI: 10.1042/Bj20060627  0.316
2006 Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. The Journal of Biological Chemistry. 281: 28068-78. PMID 16857681 DOI: 10.1074/Jbc.M604992200  0.315
2006 Daly NL, Chen Y, Foley FM, Bansal PS, Bharathi R, Clark RJ, Sommerhoff CP, Craik DJ. The Absolute Structural Requirement for a Proline in the P3′-position of Bowman-Birk Protease Inhibitors Is Surmounted in the Minimized SFTI-1 Scaffold Journal of Biological Chemistry. 281: 23668-23675. PMID 16766795 DOI: 10.1074/Jbc.M601426200  0.314
2006 Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ. The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Journal of Biological Chemistry. 281: 23254-23263. PMID 16754662 DOI: 10.1074/Jbc.M604550200  0.421
2006 Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Journal of Biological Chemistry. 281: 14136-14143. PMID 16500898 DOI: 10.1074/Jbc.M512419200  0.442
2006 Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ. Discovery and Characterization of a Linear Cyclotide from Viola odorata: Implications for the Processing of Circular Proteins Journal of Molecular Biology. 357: 1522-1535. PMID 16488428 DOI: 10.1016/J.Jmb.2006.01.051  0.356
2006 Chen B, Colgrave ML, Wang C, Craik DJ. Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. Journal of Natural Products. 69: 23-8. PMID 16441062 DOI: 10.1021/Np050317I  0.322
2006 Clark RJ, Daly NL, Craik DJ. Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochemical Journal. 394: 85-93. PMID 16300479 DOI: 10.1042/Bj20051691  0.323
2006 Daly NL, Clark RJ, Plan MR, Craik DJ. Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif Biochemical Journal. 393: 619-626. PMID 16207177 DOI: 10.1042/Bj20051371  0.303
2006 Craik DJ, Rosengren KJ, Sando L, Simonsen SS. Threaded rings and complex topologies in antimicrobial peptides: Nature's engineering templates Biopolymers. 9: 243-247. DOI: 10.1007/978-0-387-26575-9_101  0.348
2005 Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Göransson U, Craik DJ. A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). The Plant Cell. 17: 3176-89. PMID 16199617 DOI: 10.1105/Tpc.105.034678  0.592
2005 Clark RJ, Fischer H, Dempster L, Daly NL, Rosengren KJ, Nevin ST, Meunier FA, Adams DJ, Craik DJ. Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII Proceedings of the National Academy of Sciences of the United States of America. 102: 13767-13772. PMID 16162671 DOI: 10.1073/Pnas.0504613102  0.478
2005 Jennings CV, Rosengren KJ, Daly NL, Plan M, Stevens J, Scanlon MJ, Waine C, Norman DG, Anderson MA, Craik DJ. Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? Biochemistry. 44: 851-60. PMID 15654741 DOI: 10.1021/Bi047837H  0.339
2004 Korsinczky MLJ, Schirra HJ, Craik DJ. Sunflower trypsin inhibitor-1. Current Protein & Peptide Science. 5: 351-364. PMID 15544530 DOI: 10.2174/1389203043379594  0.325
2004 Rosengren KJ, Göransson U, Otvos L, Craik DJ. Cyclization of pyrrhocoricin retains structural elements crucial for the antimicrobial activity of the native peptide. Biopolymers. 76: 446-58. PMID 15478127 DOI: 10.1002/Bip.20159  0.623
2004 Trabi M, Craik DJ. Tissue-Specific Expression of Head-to-Tail Cyclized Miniproteins in Violaceae and Structure Determination of the Root Cyclotide Viola hederacea root cyclotide1 The Plant Cell. 16: 2204-2216. PMID 15295104 DOI: 10.1105/Tpc.104.021790  0.323
2004 Trabi M, Svangård E, Herrmann A, Göransson U, Claeson P, Craik DJ, Bohlin L. Variations in cyclotide expression in viola species. Journal of Natural Products. 67: 806-10. PMID 15165141 DOI: 10.1021/Np034068E  0.719
2004 Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. The Journal of Biological Chemistry. 279: 25774-82. PMID 15044438 DOI: 10.1074/Jbc.M313002200  0.406
2004 Rosengren J, Jen F, Clark R, Daly N, Göransson U, Jones A, Craik D. A novel threaded ring structure for the antimicrobial peptide microcin J25 Journal of Peptide Science. 10: 116-116. DOI: 10.1002/Psc.617  0.531
2003 Rosengren KJ, Clark RJ, Daly NL, Göransson U, Jones A, Craik DJ. Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society. 125: 12464-74. PMID 14531690 DOI: 10.1021/Ja0367703  0.643
2003 Göransson U, Craik DJ. Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. The Journal of Biological Chemistry. 278: 48188-96. PMID 12960160 DOI: 10.1074/Jbc.M308771200  0.594
2003 Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/Jm020426J  0.48
2003 Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/Jbc.M210280200  0.319
2003 daly NL, clark RJ, Göransson U, craik DJ. Diversity in the disulfide folding pathways of cystine knot peptides Letters in Peptide Science. 10: 523-531. DOI: 10.1007/Bf02442584  0.615
2002 Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ. A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity. The Journal of Biological Chemistry. 277: 48849-57. PMID 12376538 DOI: 10.1074/Jbc.M208842200  0.459
2002 Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/Jbc.M201611200  0.389
2001 Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ. Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter. Nature Neuroscience. 4: 902-7. PMID 11528421 DOI: 10.1038/Nn0901-902  0.419
2001 Trabi M, Schirra HJ, Craik DJ. Three-dimensional structure of RTD-1, a cyclic antimicrobial defensin from Rhesus macaque leukocytes. Biochemistry. 40: 4211-4221. PMID 11284676 DOI: 10.1021/Bi002028T  0.335
2001 Craik DJ, Daly NL, Waine C. The cystine knot motif in toxins and implications for drug design. Toxicon. 39: 43-60. PMID 10936622 DOI: 10.1016/S0041-0101(00)00160-4  0.329
2001 Blanchfield J, Dutton J, Hogg R, Craik D, Adams D, Lewis R, Alewood P, Toth I. The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Letters in Peptide Science. 8: 235-239. DOI: 10.1023/A:1016577832311  0.436
2000 McManus AM, Dawson NF, Wade JD, Carrington LE, Winzor DJ, Craik DJ. Three-dimensional structure of RK-1: A novel α-defensin peptide Biochemistry. 39: 15757-15764. PMID 11123900 DOI: 10.1021/Bi000457L  0.317
2000 Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A, Matheson JL, Drinkwater R, Andrews PR, Alewood PF. Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. The Journal of Biological Chemistry. 275: 35335-44. PMID 10938268 DOI: 10.1074/Jbc.M002252200  0.354
2000 Hill JM, Atkins AR, Loughnan ML, Jones A, Adams DA, Martin RC, Lewis RJ, Craik DJ, Alewood PF. Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry / Febs. 267: 4642-8. PMID 10903496 DOI: 10.1046/J.1432-1327.2000.01508.X  0.304
2000 Dawson NF, Craik DJ, Mcmanus AM, Dashper SG, Reynolds EC, Tregear GW, Otvos L, Wade JD. Chemical synthesis, characterization and activity of RK-1, a novel alpha-defensin-related peptide Journal of Peptide Science. 6: 19-25. PMID 10674716 DOI: 10.1002/(Sici)1099-1387(200001)6:1<19::Aid-Psc230>3.0.Co;2-1  0.304
1999 Craik DJ, Daly NL, Bond T, Waine C. Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. Journal of Molecular Biology. 294: 1327-1336. PMID 10600388 DOI: 10.1006/Jmbi.1999.3383  0.349
1999 Hogg RC, Miranda LP, Craik DJ, Lewis RJ, Alewood PF, Adams DJ. Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 274: 36559-64. PMID 10593955 DOI: 10.1074/Jbc.274.51.36559  0.34
1999 Nielsen KJ, Adams D, Thomas L, Bond T, Alewood PF, Craik DJ, Lewis RJ. Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology. 289: 1405-21. PMID 10373375 DOI: 10.1006/Jmbi.1999.2817  0.446
1999 Wilce JA, Salvatore D, Wade JD, Craik DJ. 1H-NMR structural studies of a cystine-linked peptide containing residues 71-93 of transthyretin and effects of a Ser84 substitution implicated in familial amyloidotic polyneuropathy European Journal of Biochemistry. 262: 586-594. PMID 10336646 DOI: 10.1046/J.1432-1327.1999.00423.X  0.319
1999 Harrison SJ, McManus AM, Marcus JP, Goulter KC, Green JL, Nielsen KJ, Craik DJ, Maclean DJ, Manners JM. Purification and characterization of a plant antimicrobial peptide expressed in Escherichia coli. Protein Expression and Purification. 15: 171-7. PMID 10049672 DOI: 10.1006/Prep.1998.0992  0.303
1999 McManus AM, Otvos L, Hoffmann R, Craik DJ. Conformational studies by NMR of the antimicrobial peptide, drosocin, and its non-glycosylated derivative: effects of glycosylation on solution conformation. Biochemistry. 38: 705-714. PMID 9888811 DOI: 10.1021/Bi981956D  0.303
1999 Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ. Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity Journal of Molecular Biology. 285: 333-345. PMID 9878410 DOI: 10.1006/Jmbi.1998.2276  0.302
1999 Adams DJ, Alewood PF, Craik DJ, Drinkwater RD, Lewis RJ. Conotoxins and their potential pharmaceutical applications Drug Development Research. 46: 219-234. DOI: 10.1002/(Sici)1098-2299(199903/04)46:3/4<219::Aid-Ddr7>3.0.Co;2-S  0.452
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