David J. Craik - Publications

Affiliations: 
IMB University of Queensland, Saint Lucia, Queensland, Australia 

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lawrence N, Handley TNG, de Veer SJ, Harding MD, Andraszek A, Hall L, Raven KD, Duffy S, Avery VM, Craik DJ, Malins LR, McMorran BJ. Enhancing the Intrinsic Antiplasmodial Activity and Improving the Stability and Selectivity of a Tunable Peptide Scaffold Derived from Human Platelet Factor 4. Acs Infectious Diseases. PMID 39087267 DOI: 10.1021/acsinfecdis.4c00276  0.337
2024 Koehbach J, Muratspahić E, Ahmed ZM, White AM, Tomašević N, Durek T, Clark RJ, Gruber CW, Craik DJ. Chemical synthesis of grafted cyclotides using a "plug and play" approach. Rsc Chemical Biology. 5: 567-571. PMID 38846076 DOI: 10.1039/d4cb00008k  0.323
2024 Hone AJ, Santiago U, Harvey PJ, Tekarli B, Gajewiak J, Craik DJ, Camacho CJ, McIntosh JM. Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry. PMID 38814877 DOI: 10.1021/acs.jmedchem.4c00735  0.343
2024 Rehm FBH, Tyler TJ, Zhou Y, Huang YH, Wang CK, Lawrence N, Craik DJ, Durek T. Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry. PMID 38789555 DOI: 10.1038/s41557-024-01520-1  0.342
2024 Khatibi N, Huang YH, Wang CK, Durek T, Gilding EK, Craik DJ. Isolation and Characterization of Insecticidal Cyclotides from . Journal of Natural Products. PMID 38747744 DOI: 10.1021/acs.jnatprod.4c00168  0.328
2024 Philippe GJ, Huang YH, Mittermeier A, Brown CJ, Kaas Q, Ramlan SR, Wang CK, Lane D, Loewer A, Troeira Henriques S, Craik DJ. Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry. PMID 38174919 DOI: 10.1021/acs.jmedchem.3c01682  0.306
2024 Baquero F, Beis K, Craik DJ, Li Y, Link AJ, Rebuffat S, Salomón R, Severinov K, Zirah S, Hegemann JD. The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide. Natural Product Reports. PMID 38164764 DOI: 10.1039/d3np00046j  0.319
2023 Muratspahić E, Aslanoglou D, White AM, Draxler C, Kozisek X, Farooq Z, Craik DJ, McCormick PJ, Durek T, Gruber CW. Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds. Acs Pharmacology & Translational Science. 6: 1373-1381. PMID 37854631 DOI: 10.1021/acsptsci.3c00090  0.334
2023 Tyler TJ, Durek T, Craik DJ. Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads. Molecules (Basel, Switzerland). 28. PMID 37049950 DOI: 10.3390/molecules28073189  0.307
2023 Jackson MA, Xie J, Nguyen LTT, Wang X, Yap K, Harvey PJ, Gilding EK, Craik DJ. Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis. Transgenic Research. PMID 36930229 DOI: 10.1007/s11248-023-00341-1  0.316
2023 Cao Q, Ge C, Wang X, Harvey PJ, Zhang Z, Ma Y, Wang X, Jia X, Mobli M, Craik DJ, Jiang T, Yang J, Wei Z, Wang Y, Chang S, et al. Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics. PMID 36857616 DOI: 10.1093/bib/bbad058  0.317
2022 Zhang Y, Wang L, Tombling BJ, Lammi C, Huang YH, Li Y, Bartolomei M, Hong B, Craik DJ, Wang CK. Improving Stability Enhances In Vivo Efficacy of a PCSK9 Inhibitory Peptide. Journal of the American Chemical Society. PMID 36222719 DOI: 10.1021/jacs.2c08029  0.321
2022 White AM, Dellsén A, Larsson N, Kaas Q, Jansen F, Plowright AT, Knerr L, Durek T, Craik DJ. Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. Journal of Medicinal Chemistry. PMID 36167503 DOI: 10.1021/acs.jmedchem.2c00793  0.328
2022 Cardoso MH, Chan LY, Cândido ES, Buccini DF, Rezende SB, Torres MDT, Oshiro KGN, Silva ÍC, Gonçalves S, Lu TK, Santos NC, de la Fuente-Nunez C, Craik DJ, Franco OL. An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. Chemical Science. 13: 9410-9424. PMID 36093022 DOI: 10.1039/d1sc06998e  0.357
2022 Dang TT, Huang YH, Ott S, Harvey PJ, Gilding EK, Tombling BJ, Chan LY, Kaas Q, Claridge-Chang A, Craik DJ. The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. The Journal of Biological Chemistry. 102413. PMID 36007611 DOI: 10.1016/j.jbc.2022.102413  0.327
2022 Jackson MA, Chan LY, Harding MD, Craik DJ, Gilding EK. Rational domestication of a plant-based recombinant expression system expands its biosynthetic range. Journal of Experimental Botany. PMID 35724659 DOI: 10.1093/jxb/erac273  0.32
2022 Du Q, Huang YH, Wang CK, Kaas Q, Craik DJ. Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. The Journal of Biological Chemistry. 101822. PMID 35283188 DOI: 10.1016/j.jbc.2022.101822  0.321
2022 Jakob V, Zoller BGE, Rinkes J, Wu Y, Kiefer AF, Hust M, Polten S, White AM, Harvey PJ, Durek T, Craik DJ, Siebert A, Kazmaier U, Empting M. Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry. 231: 114148. PMID 35114538 DOI: 10.1016/j.ejmech.2022.114148  0.342
2022 Wu Y, Cui Z, Huang YH, de Veer SJ, Aralov AV, Guo Z, Moradi SV, Hinton AO, Deuis JR, Guo S, Chen KE, Collins BM, Vetter I, Herzig V, Jones A, ... ... Craik DJ, et al. Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications. 13: 260. PMID 35017494 DOI: 10.1038/s41467-021-27854-9  0.322
2022 Handley TNG, Jackson MA, Craik DJ. Scalable and Efficient In Planta Biosynthesis of Sunflower Trypsin Inhibitor-1 (SFTI) Peptide Therapeutics. Methods in Molecular Biology (Clifton, N.J.). 2371: 117-142. PMID 34596846 DOI: 10.1007/978-1-0716-1689-5_7  0.328
2021 Tran HNT, Tran P, Deuis JR, McMahon KL, Yap K, Craik DJ, Vetter I, Schroeder CI. Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides. Bioconjugate Chemistry. PMID 34751572 DOI: 10.1021/acs.bioconjchem.1c00452  0.358
2021 Yousuf A, Wu X, Bony AR, Sadeghi M, Huang YH, Craik DJ, Adams DJ. ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (Ca 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABA receptor activation. Journal of Neurochemistry. PMID 34738241 DOI: 10.1111/jnc.15535  0.33
2021 Hellinger R, Muratspahić E, Devi S, Koehbach J, Vasileva M, Harvey PJ, Craik DJ, Gründemann C, Gruber CW. Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides. Acs Chemical Biology. 16: 2373-2386. PMID 34592097 DOI: 10.1021/acschembio.1c00524  0.348
2021 Tombling BJ, Zhang Y, Huang YH, Craik DJ, Wang CK. The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis. 330: 52-60. PMID 34246818 DOI: 10.1016/j.atherosclerosis.2021.06.903  0.309
2021 Koehbach J, Gani J, Hilpert K, Craik DJ. Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens. Microorganisms. 9. PMID 34201398 DOI: 10.3390/microorganisms9061249  0.332
2021 Yin H, Huang YH, Best SA, Sutherland KD, Craik DJ, Wang CK. An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors. Acs Chemical Biology. PMID 34152716 DOI: 10.1021/acschembio.1c00388  0.326
2021 Tombling BJ, Lammi C, Bollati C, Anoldi A, Craik DJ, Wang CK. Increased Valency Improves Inhibitory Activity of Peptides Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9). Chembiochem : a European Journal of Chemical Biology. 22: 2154-2160. PMID 33755275 DOI: 10.1002/cbic.202100103  0.322
2021 Yap K, Du J, Rehm FBH, Tang SR, Zhou Y, Xie J, Wang CK, de Veer SJ, Lua LHL, Durek T, Craik DJ. Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols. PMID 33597770 DOI: 10.1038/s41596-020-00483-0  0.361
2021 Dang TT, Chan LY, Tombling BJ, Harvey PJ, Gilding EK, Craik DJ. In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from . Journal of Natural Products. PMID 33570395 DOI: 10.1021/acs.jnatprod.0c01065  0.373
2021 Philippe GJB, Craik DJ, Henriques ST. Converting peptides into drugs targeting intracellular protein-protein interactions. Drug Discovery Today. PMID 33524603 DOI: 10.1016/j.drudis.2021.01.022  0.315
2021 Pinto MEF, Chan LY, Koehbach J, Devi S, Gründemann C, Gruber CW, Gomes M, Bolzani VS, Cilli EM, Craik DJ. Cyclotides from Brazilian and Their Effects on Human Lymphocytes. Journal of Natural Products. PMID 33397096 DOI: 10.1021/acs.jnatprod.0c01069  0.32
2020 Lawrence N, Philippe GJ, Harvey PJ, Condon ND, Benfield AH, Cheneval O, Craik DJ, Troeira Henriques S. Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells. Rsc Chemical Biology. 1: 405-420. PMID 34458771 DOI: 10.1039/d0cb00099j  0.352
2020 Muratspahić E, Koehbach J, Gruber CW, Craik DJ. Harnessing cyclotides to design and develop novel peptide GPCR ligands. Rsc Chemical Biology. 1: 177-191. PMID 34458757 DOI: 10.1039/d0cb00062k  0.34
2020 Tombling BJ, Lammi C, Lawrence N, Gilding EK, Grazioso G, Craik DJ, Wang CK. Bioactive Cyclization Optimizes the Affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Peptide Inhibitor. Journal of Medicinal Chemistry. PMID 33356222 DOI: 10.1021/acs.jmedchem.0c01766  0.355
2020 Muller JAI, Lawrence N, Chan LY, Harvey PJ, Elliott AG, Blaskovich MAT, Gonçalves JC, Galante P, Mortari MR, Toffoli-Kadri MC, Koehbach J, Craik D. Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus. Chembiochem : a European Journal of Chemical Biology. PMID 33244888 DOI: 10.1002/cbic.202000716  0.314
2020 Jackson MA, Nguyen LTT, Gilding EK, Durek T, Craik DJ. Make it or break it: Plant AEPs on stage in biotechnology. Biotechnology Advances. 107651. PMID 33141031 DOI: 10.1016/j.biotechadv.2020.107651  0.313
2020 Gilding EK, Jami S, Deuis JR, Israel MR, Harvey PJ, Poth AG, Rehm FBH, Stow JL, Robinson SD, Yap K, Brown DL, Hamilton BR, Andersson D, Craik DJ, Vetter I, et al. Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances. 6. PMID 32938666 DOI: 10.1126/Sciadv.Abb8828  0.363
2020 Bleackley MR, Vasa S, Harvey PJ, Shafee TMA, Kerenga BK, Soares da Costa TP, Craik DJ, Lowe RGT, Anderson MA. Histidine-Rich Defensins from the and Are Antifungal and Metal Binding Proteins. Journal of Fungi (Basel, Switzerland). 6. PMID 32847065 DOI: 10.3390/Jof6030145  0.349
2020 Peacock H, Henriques ST, Benfield AH, Elliott AG, Luo J, Luccarelli J, Nagano M, Craik DJ, Hamilton AD. Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis and activity. Chemmedchem. PMID 32754982 DOI: 10.1002/Cmdc.202000474  0.441
2020 Handley TNG, Harvey PJ, Wang CK, Lawrence N, Craik D. Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. Chembiochem : a European Journal of Chemical Biology. PMID 32656966 DOI: 10.1002/Cbic.202000315  0.36
2020 Wang CK, Amiss AS, Weidmann J, Craik DJ. Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery. The Journal of Biological Chemistry. PMID 32647013 DOI: 10.1074/Jbc.Ra120.014168  0.317
2020 Peigneur S, Tsarev AV, Paramonov AS, Schroeder CI, Ikonomopoulou MP, Inagaki H, Craik DJ, Konno K, Shenkarev ZO, Tytgat J. The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels. Toxicon : Official Journal of the International Society On Toxinology. 177: S40. PMID 32635028 DOI: 10.1016/J.Toxicon.2019.12.069  0.348
2020 de Veer SJ, White AM, Craik D. Sunflower Trypsin Inhibitor-1 (SFTI-1): Sowing Seeds in the Fields of Chemistry and Biology. Angewandte Chemie (International Ed. in English). PMID 32621554 DOI: 10.1002/Anie.202006919  0.446
2020 Huynh PN, Harvey PJ, Gajewiak J, Craik DJ, Michael McIntosh J. Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors. Biochemical Pharmacology. 114124. PMID 32593612 DOI: 10.1016/J.Bcp.2020.114124  0.372
2020 Du Q, Chan LY, Gilding EK, Henriques ST, Condon ND, Ravipati AS, Kaas Q, Huang YH, Craik DJ. Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. The Journal of Biological Chemistry. PMID 32414842 DOI: 10.1074/Jbc.Ra120.012627  0.339
2020 Yin H, Huang YH, Deprey K, Condon ND, Kritzer JA, Craik DJ, Wang CK. Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. Acs Chemical Biology. PMID 32315152 DOI: 10.1021/Acschembio.0C00297  0.421
2020 White A, de Veer S, Wu G, Harvey P, Yap K, King GJ, Swedberg JE, Wang CK, Law RHP, Durek T, Craik D. Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angewandte Chemie (International Ed. in English). PMID 32270580 DOI: 10.1002/Anie.202003435  0.465
2020 Du J, Yap K, Chan LY, Rehm FBH, Looi FY, Poth AG, Gilding EK, Kaas Q, Durek T, Craik DJ. A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications. 11: 1575. PMID 32221295 DOI: 10.1038/S41467-020-15418-2  0.379
2020 Smithies BJ, Huang YH, Jackson MA, Yap K, Gilding EK, Harris KS, Anderson MA, Craik DJ. Circular permutation of the native enzyme-mediated cyclization position in cyclotides. Acs Chemical Biology. PMID 32203656 DOI: 10.1021/Acschembio.9B00996  0.424
2020 Agwa AJ, Tran P, Mueller A, Tran HNT, Deuis JR, Israel MR, McMahon KL, Craik DJ, Vetter I, Schroeder CI. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry. PMID 32139508 DOI: 10.1074/Jbc.Ra119.012281  0.323
2020 Yu R, Wang J, So LY, Harvey PJ, Shi J, Liang J, Dou Q, Li X, Yan X, Huang YH, Xu Q, Kaas Q, Chow HY, Wong KY, Craik DJ, et al. Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. Journal of Medicinal Chemistry. PMID 32003561 DOI: 10.1021/Acs.Jmedchem.9B01563  0.336
2020 Xu P, Kaas Q, Wu Y, Zhu X, Li X, Harvey PJ, Zhangsun D, Craik DJ, Luo S. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. Journal of Medicinal Chemistry. PMID 31986036 DOI: 10.1021/Acs.Jmedchem.9B01409  0.447
2020 Hansen IKØ, Isaksson J, Poth AG, Hansen KØ, Andersen AJC, Richard CSM, Blencke HM, Stensvåg K, Craik DJ, Haug T. Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian . Marine Drugs. 18. PMID 31940927 DOI: 10.3390/Md18010051  0.439
2020 Kan M, Craik DJ. Discovery of cyclotides from Australasian plants Australian Journal of Chemistry. 73: 287-299. DOI: 10.1071/Ch19658  0.427
2020 Yap K, Du J, Looi FY, Tang SR, Veer SJd, Bony AR, Rehm FBH, Xie J, Chan LY, Wang CK, Adams DJ, Lua LHL, Durek T, Craik DJ. An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides Green Chemistry. 22: 5002-5016. DOI: 10.1039/D0Gc01366H  0.549
2020 Oguis GK, Gilding EK, Huang Y, Poth AG, Jackson MA, Craik DJ. Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions Industrial Crops and Products. 147: 112214. DOI: 10.1016/J.Indcrop.2020.112214  0.401
2020 Troeira Henriques S, Peacock H, Benfield AH, Wang CK, Craik D. Challenging the Chirality Paradigm in Peptide-Lipid Interactions Biophysical Journal. 118: 343a. DOI: 10.1016/J.Bpj.2019.11.1983  0.367
2020 White AM, Veer SJd, Wu G, Harvey PJ, Yap K, King GJ, Swedberg JE, Wang CK, Law RHP, Durek T, Craik DJ. Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020) Angewandte Chemie. 59: 11162-11162. DOI: 10.1002/Anie.202006713  0.44
2020 White AM, Veer SJd, Wu G, Harvey PJ, Yap K, King GJ, Swedberg JE, Wang CK, Law RHP, Durek T, Craik DJ. Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020) Angewandte Chemie. 132: 11258-11258. DOI: 10.1002/Ange.202006713  0.447
2019 Bleackley MR, Dawson CS, Payne JAE, Harvey PJ, Rosengren KJ, Quimbar P, Garcia-Ceron D, Lowe R, Bulone V, van der Weerden NL, Craik DJ, Anderson MA. The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. Cell Surface (Amsterdam, Netherlands). 5: 100026. PMID 32743142 DOI: 10.1016/J.Tcsw.2019.100026  0.357
2019 Tombling BJ, Wang CK, Craik DJ. EGF-like and Other Disulfide-rich Microdomains as Therapeutic Scaffolds. Angewandte Chemie (International Ed. in English). PMID 31867866 DOI: 10.1002/Anie.201913809  0.371
2019 Li CY, Yap K, Swedberg J, Craik DJ, de Veer SJ. Binding loop substitutions in the cyclic peptide SFTI-1 generate potent and selective chymase inhibitors. Journal of Medicinal Chemistry. PMID 31855419 DOI: 10.1021/Acs.Jmedchem.9B01811  0.406
2019 de Veer SJ, Kan MW, Craik DJ. Cyclotides: From Structure to Function. Chemical Reviews. PMID 31829013 DOI: 10.1021/Acs.Chemrev.9B00402  0.464
2019 Troeira Henriques S, Peacock H, Benfield A, Wang CK, Craik DJ. Is the mirror image a true reflection? Intrinsic membrane chirality modulates peptide binding. Journal of the American Chemical Society. PMID 31765148 DOI: 10.1021/Jacs.9B11194  0.407
2019 Vernen F, Craik DJ, Lawrence N, Troeira Henriques S. Cyclic analogues of horseshoe crab peptide tachyplesin I with anticancer and cell penetrating properties. Acs Chemical Biology. PMID 31714739 DOI: 10.1021/Acschembio.9B00782  0.443
2019 Huang YH, Du Q, Craik DJ. Cyclotides: disulfide-rich peptide toxins in plants. Toxicon : Official Journal of the International Society On Toxinology. PMID 31682883 DOI: 10.1016/J.Toxicon.2019.10.244  0.42
2019 Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Conotoxins: Chemistry and Biology. Chemical Reviews. PMID 31633928 DOI: 10.1021/Acs.Chemrev.9B00207  0.427
2019 Sang J, Kulkarni K, Watson GM, Ma X, Craik DJ, Henriques ST, Poth AG, Benfield AH, Wilce JA. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules (Basel, Switzerland). 24. PMID 31627265 DOI: 10.3390/Molecules24203739  0.426
2019 Rehm FBH, Harmand TJ, Yap K, Durek T, Craik DJ, Ploegh HL. Site-specific sequential protein labeling catalyzed by a single recombinant ligase. Journal of the American Chemical Society. PMID 31573802 DOI: 10.1021/Jacs.9B09166  0.302
2019 Vernen F, Harvey PJ, Dias SA, Veiga AS, Huang YH, Craik DJ, Lawrence N, Troeira Henriques S. Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. International Journal of Molecular Sciences. 20. PMID 31455019 DOI: 10.3390/Ijms20174184  0.463
2019 Ma H, Qiu P, Harvey PJ, Li X, Zhang Z, Xu Q, Liang J, Kaas Q, Craik DJ, Yang J, Jiang T, Bi X, Yu R. In Silico Design of MDM2-Targeting Peptides from Naturally Occurring Constrained Peptide. Chemmedchem. PMID 31444979 DOI: 10.1002/Cmdc.201900366  0.429
2019 Tian S, Swedberg JE, Li CY, Craik DJ, de Veer SJ. Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3. Acs Medicinal Chemistry Letters. 10: 1234-1239. PMID 31413811 DOI: 10.1021/Acsmedchemlett.9B00253  0.343
2019 Oshiro KGN, Cândido ES, Chan LY, Torres MT, Monges BED, Rodrigues SG, Porto WF, Ribeiro SM, Troeira Henriques S, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL, Cardoso MH. Computer-aided design of mastoparan-like peptides enables the generation of non-toxic variants with extended antibacterial properties. Journal of Medicinal Chemistry. PMID 31411881 DOI: 10.1021/Acs.Jmedchem.9B00915  0.337
2019 Philippe GJ, Gaspar D, Sheng C, Huang YH, Benfield AH, Condon ND, Weidmann J, Lawrence N, Löwer A, Castanho MARB, Craik DJ, Troeira Henriques S. Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties. Acs Chemical Biology. PMID 31390185 DOI: 10.1021/Acschembio.9B00593  0.38
2019 Harris KS, Guarino RF, Dissanayake RS, Quimbar P, McCorkelle OC, Poon S, Kaas Q, Durek T, Gilding EK, Jackson MA, Craik DJ, van der Weerden NL, Anders RF, Anderson MA. A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports. 9: 10820. PMID 31346249 DOI: 10.1038/S41598-019-47273-7  0.446
2019 Nicolas S, Zoukimian C, Bosmans F, Montnach J, Diochot S, Cuypers E, De Waard S, Béroud R, Mebs D, Craik D, Boturyn D, Lazdunski M, Tytgat J, De Waard M. Chemical Synthesis, Proper Folding, Na Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins. 11. PMID 31234412 DOI: 10.3390/Toxins11060367  0.403
2019 Koehbach J, Craik DJ. The Vast Structural Diversity of Antimicrobial Peptides. Trends in Pharmacological Sciences. 40: 517-528. PMID 31230616 DOI: 10.1016/J.Tips.2019.04.012  0.455
2019 El Hamdaoui Y, Wu X, Clark RJ, Giribaldi J, Anangi R, Craik DJ, King GF, Dutertre S, Kaas Q, Herzig V, Nicke A. Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Frontiers in Pharmacology. 10: 577. PMID 31214027 DOI: 10.3389/Fphar.2019.00577  0.458
2019 Oguis GK, Gilding EK, Jackson MA, Craik DJ. Butterfly Pea (), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine. Frontiers in Plant Science. 10: 645. PMID 31191573 DOI: 10.3389/Fpls.2019.00645  0.439
2019 Agwa AJ, Craik DJ, Schroeder CI. Cyclizing Disulfide-Rich Peptides Using Sortase A. Methods in Molecular Biology (Clifton, N.J.). 2012: 29-41. PMID 31161502 DOI: 10.1007/978-1-4939-9546-2_3  0.438
2019 Jackson MA, Yap K, Poth AG, Gilding EK, Swedberg JE, Poon S, Qu H, Durek T, Harris K, Anderson MA, Craik DJ. Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide. Frontiers in Plant Science. 10: 602. PMID 31156672 DOI: 10.3389/Fpls.2019.00602  0.447
2019 Poth AG, Huang YH, Le TT, Kan MW, Craik DJ. Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. International Journal of Pharmaceutics. PMID 31063836 DOI: 10.1016/J.Ijpharm.2019.05.001  0.319
2019 Yu R, Tae HS, Xu Q, Craik DJ, Adams DJ, Jiang T, Kaas Q. Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British Journal of Pharmacology. PMID 31062355 DOI: 10.1111/Bph.14698  0.4
2019 Kerenga BK, McKenna JA, Harvey PJ, Quimbar P, Garcia-Ceron D, Lay FT, Phan TK, Veneer PK, Vasa S, Parisi K, Shafee TMA, van der Weerden NL, Hulett MD, Craik DJ, Anderson MA, et al. Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. Frontiers in Microbiology. 10: 795. PMID 31031739 DOI: 10.3389/Fmicb.2019.00795  0.404
2019 Cândido ES, Cardoso MH, Chan LY, Torres MT, Oshiro K, Porto WF, Ribeiro SM, Haney EF, Hancock REW, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL. A short cationic peptide derived from Archaea with dual antibacterial properties and anti-infective potential. Acs Infectious Diseases. PMID 31016969 DOI: 10.1021/Acsinfecdis.9B00073  0.394
2019 Rehm FBH, Jackson MA, De Geyter E, Yap K, Gilding EK, Durek T, Craik DJ. Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences of the United States of America. PMID 30944220 DOI: 10.1073/Pnas.1901807116  0.422
2019 Yin H, Craik D, Wang CK. Anchor residues guide form and function in grafted peptides. Angewandte Chemie (International Ed. in English). PMID 30916847 DOI: 10.1002/Anie.201901572  0.457
2019 Li CY, de Veer SJ, White AM, Chen X, Harris JM, Swedberg JE, Craik DJ. Amino Acid Scanning at P5' Within the Bowman‒Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases. Journal of Medicinal Chemistry. PMID 30888159 DOI: 10.1021/Acs.Jmedchem.9B00211  0.351
2019 Schmidt M, Huang YH, Texeira de Oliveira EF, Toplak A, Wijma HJ, Janssen DB, van Maarseveen JH, Craik DJ, Nuijens T. Efficient Enzymatic Cyclization of Disulfide-rich Peptides using Peptiligases. Chembiochem : a European Journal of Chemical Biology. PMID 30735312 DOI: 10.1002/Cbic.201900033  0.398
2019 Wang CK, Craik DJ. Towards Structure Determination of Disulfide-Rich Peptides Using Chemical Shift-Based Methods. The Journal of Physical Chemistry. B. PMID 30730741 DOI: 10.1021/Acs.Jpcb.8B10649  0.438
2019 Du J, Chan LY, Poth AG, Craik DJ. Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. Journal of Natural Products. PMID 30673219 DOI: 10.1021/Acs.Jnatprod.8B00716  0.472
2019 Cardoso MH, Chan LY, Candido ES, Torres MT, Oshiro KGN, Silva IC, Goncalves S, Buccini DF, Lu T, Santos NC, Fuente-Nunez Cdl, Craik DJ, Franco OL. TFE-induced NMR structure of a novel bioactive peptide (PaDBS1R7) derived from a Pyrobaculum aerophilum ribosomal protein (L39e) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6Ct1/Pdb  0.443
2019 Cardoso MH, Chan LY, Candido ES, Torres MT, Oshiro KGN, Silva IC, Goncalves S, Buccini DF, Lu T, Santos NC, Fuente-Nunez Cdl, Craik DJ, Franco OL. TFE-induced NMR structure of a novel bioactive peptide (PaDBS1R2) derived from a Pyrobaculum aerophilum ribosomal protein (L39e) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6Csk/Pdb  0.443
2019 Silva ON, Pinto MFS, Viana JFC, Freitas CG, Fensterseifer ICM, Craik DJ, Franco OL. Evaluation of the in vitro Antitumor Activity of Nanostructured Cyclotides in Polymers of Eudragit® L 100-55 and RS 30 D Letters in Drug Design & Discovery. 16: 437-445. DOI: 10.2174/1570180815666180801115526  0.322
2019 Craik DJ. Peptide toxins from plants and animals as tools in drud design Toxicon. 158. DOI: 10.1016/J.Toxicon.2018.10.010  0.389
2018 Swedberg JE, Ghani HA, Harris JM, de Veer SJ, Craik DJ. Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II. Acs Medicinal Chemistry Letters. 9: 1258-1262. PMID 30613336 DOI: 10.1021/Acsmedchemlett.8B00422  0.34
2018 Dash TS, Shafee T, Harvey PJ, Zhang C, Peigneur S, Deuis JR, Vetter I, Tytgat J, Anderson MA, Craik DJ, Durek T, Undheim EAB. A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins. Structure (London, England : 1993). PMID 30554841 DOI: 10.1016/J.Str.2018.10.022  0.437
2018 Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J. Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801909R. PMID 30509130 DOI: 10.1096/Fj.201801909R  0.426
2018 Lawrence N, Wu B, Ligutti J, Cheneval O, Agwa AJ, Benfield AH, Biswas K, Craik DJ, Miranda LP, Troeira Henriques S, Schroeder CI. Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. Acs Chemical Biology. PMID 30507158 DOI: 10.1021/Acschembio.8B00989  0.373
2018 Niyomploy P, Chan LY, Harvey PJ, Poth AG, Colgrave ML, Craik DJ. Discovery and Characterization of Cyclotides from Rinorea Species. Journal of Natural Products. PMID 30387611 DOI: 10.1021/Acs.Jnatprod.8B00572  0.344
2018 Harvey PJ, Kurniawan ND, Finol-Urdaneta RK, McArthur JR, Van Lysebetten D, Dash TS, Hill JM, Adams DJ, Durek T, Craik DJ. NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency. Molecules (Basel, Switzerland). 23. PMID 30360356 DOI: 10.3390/Molecules23102715  0.525
2018 Cardoso M, Cândido E, Chan L, Torres MT, Oshiro K, Rezende S, Porto WF, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL. A computationally designed peptide derived from Escherichia colias a potential drug template for antibacterial and antibiofilm therapies. Acs Infectious Diseases. PMID 30346140 DOI: 10.1021/Acsinfecdis.8B00219  0.422
2018 Ramalho SD, Wang CK, King GJ, Byriel KA, Huang YH, Bolzani VS, Craik DJ. Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species. Journal of Natural Products. PMID 30345754 DOI: 10.1021/Acs.Jnatprod.8B00447  0.337
2018 Yu J, Zhu X, Harvey PJ, Kaas Q, Zhangsun D, Craik DJ, Luo S. A Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist. Journal of Medicinal Chemistry. PMID 30252466 DOI: 10.1021/Acs.Jmedchem.8B00967  0.331
2018 Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL. Targeted delivery of cyclotides via conjugation to a nanobody. Acs Chemical Biology. PMID 30248263 DOI: 10.1021/Acschembio.8B00653  0.418
2018 Li CY, de Veer SJ, Law RHP, Whisstock JC, Craik D, Swedberg JE. Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. Chembiochem : a European Journal of Chemical Biology. PMID 30225958 DOI: 10.1002/Cbic.201800395  0.389
2018 Agwa A, Blomster L, Craik DJ, King GF, Schroeder CI. Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase A to form double-knottins to probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry. PMID 30148615 DOI: 10.1021/Acs.Bioconjchem.8B00505  0.423
2018 Lawrence N, Dennis ASM, Lehane AM, Ehmann A, Harvey PJ, Benfield AH, Cheneval O, Henriques ST, Craik DJ, McMorran BJ. Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption. Cell Chemical Biology. PMID 30033131 DOI: 10.1016/J.Chembiol.2018.06.009  0.411
2018 Wu X, Tae HS, Huang YH, Adams DJ, Craik DJ, Kaas Q. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology. PMID 30009767 DOI: 10.1016/J.Bcp.2018.07.007  0.442
2018 de Veer SJ, Li CY, Swedberg JE, Schroeder CI, Craik DJ. Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry. 155: 695-704. PMID 29936356 DOI: 10.1016/J.Ejmech.2018.06.029  0.373
2018 Jackson MA, Gilding EK, Shafee T, Harris KS, Kaas Q, Poon S, Yap K, Jia H, Guarino R, Chan LY, Durek T, Anderson MA, Craik DJ. Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications. 9: 2411. PMID 29925835 DOI: 10.1038/S41467-018-04669-9  0.455
2018 Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O'Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ. Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. Acs Chemical Biology. PMID 29746088 DOI: 10.1021/Acschembio.8B00190  0.495
2018 Wang CK, Abdul Ghani H, Bundock A, Weidmann J, Harvey PJ, Edwards IA, Schroeder CI, Swedberg JE, Craik DJ. Calcium-mediated allostery of the EGF fold. Acs Chemical Biology. PMID 29715432 DOI: 10.1021/Acschembio.8B00291  0.322
2018 Agwa AJ, Peigneur S, Chow CY, Lawrence N, Craik DJ, Tytgat J, King GF, Henriques ST, Schroeder CI. Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. The Journal of Biological Chemistry. PMID 29703751 DOI: 10.1074/Jbc.Ra118.002553  0.31
2018 Wang CK, Craik DJ. Designing macrocyclic disulfide-rich peptides for biotechnological applications. Nature Chemical Biology. 14: 417-427. PMID 29662187 DOI: 10.1038/S41589-018-0039-Y  0.42
2018 Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, ... ... Craik DJ, et al. Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. Journal of Medicinal Chemistry. PMID 29605997 DOI: 10.1021/Acs.Jmedchem.8B00170  0.425
2018 Wang CK, Swedberg JE, Harvey PJ, Kaas Q, Craik DJ. Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B. PMID 29400464 DOI: 10.1021/Acs.Jpcb.7B12419  0.388
2018 Cardoso MH, Chan LY, Candido ES, Craik DJ, Franco OL. TFE-induced NMR structure of an antimicrobial peptide (EcDBS1R5) derived from a mercury transporter protein (MerP - Escherichia coli) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6Ct4/Pdb  0.42
2018 White A, Deveer S, Swedberg J, Durek T, Craik D. Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1 Journal of Peptide Science. 24. DOI: 10.1002/Psc.3127  0.391
2018 Craik DJ, Payne RJ. Emerging Peptide Science in Australia Peptide Science. 110: e24080. DOI: 10.1002/Pep2.24080  0.399
2017 Poon S, Harris KS, Jackson MA, McCorkelle OC, Gilding EK, Durek T, van der Weerden NL, Craik DJ, Anderson MA. Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. Journal of Experimental Botany. PMID 29309615 DOI: 10.1093/Jxb/Erx422  0.433
2017 Pérez-Peinado C, Almeida Dias S, Domingues MM, Benfield AH, Freire JM, Radis-Baptista G, Gaspar D, Castanho MARB, Craik DJ, Henriques ST, Veiga AS, Andreu D. Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venom. The Journal of Biological Chemistry. PMID 29255091 DOI: 10.1074/Jbc.Ra117.000125  0.365
2017 Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology. PMID 29194563 DOI: 10.1111/Bph.14115  0.395
2017 Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI. Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific Reports. 7: 16606. PMID 29192197 DOI: 10.1038/S41598-017-16809-0  0.464
2017 Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. The Journal of Biological Chemistry. PMID 28851841 DOI: 10.1074/jbc.M117.808386  0.503
2017 Craik DJ, Lee MH, Rehm FBH, Tombling B, Doffek B, Peacock H. Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds. Bioorganic & Medicinal Chemistry. PMID 28818463 DOI: 10.1016/J.Bmc.2017.08.005  0.46
2017 Agwa AJ, Huang YH, Craik DJ, Henriques ST, Schroeder CI. Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins. Toxins. 9. PMID 28805686 DOI: 10.3390/Toxins9080248  0.411
2017 Troeira Henriques S, Lawrence N, Chaousis S, Ravipati AS, Cheneval O, Benfield AH, Elliott AG, Kavanagh AM, Cooper MA, Chan LY, Huang YH, Craik DJ. Redesigned spider peptide with improved antimicrobial and anticancer properties. Acs Chemical Biology. PMID 28741926 DOI: 10.1021/Acschembio.7B00459  0.361
2017 de Veer SJ, Weidmann J, Craik DJ. Cyclotides as Tools in Chemical Biology. Accounts of Chemical Research. 50: 1557-1565. PMID 28644007 DOI: 10.1021/Acs.Accounts.7B00157  0.488
2017 Cranfield CG, Henriques ST, Martinac B, Duckworth PA, Craik DJ, Cornell B. Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine Containing Lipid Membranes. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 28605904 DOI: 10.1021/Acs.Langmuir.7B01642  0.302
2017 Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S. α-Conotoxin [S9A]TxID Potently discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry. PMID 28603989 DOI: 10.1021/Acs.Jmedchem.7B00546  0.351
2017 Ravipati AS, Poth AG, Troeira Henriques S, Bhandari M, Huang YH, Nino J, Colgrave ML, Craik DJ. Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. Journal of Natural Products. PMID 28471681 DOI: 10.1021/Acs.Jnatprod.7B00061  0.371
2017 Ojeda PG, Henriques ST, Pan Y, Nicolazzo JA, Craik DJ, Wang CK. Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers. PMID 28459137 DOI: 10.1002/Bip.23025  0.411
2017 Grage SL, Sani MA, Cheneval O, Henriques ST, Schalck C, Heinzmann R, Mylne JS, Mykhailiuk PK, Afonin S, Komarov IV, Separovic F, Craik DJ, Ulrich AS. Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR. Biophysical Journal. 112: 630-642. PMID 28256223 DOI: 10.1016/J.Bpj.2016.12.040  0.363
2017 Craik DJ, Du J. Cyclotides as drug design scaffolds. Current Opinion in Chemical Biology. 38: 8-16. PMID 28249194 DOI: 10.1016/J.Cbpa.2017.01.018  0.411
2017 Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen R, Craik DJ, Schroeder CI, Henriques ST. Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica Et Biophysica Acta. PMID 28115115 DOI: 10.1016/J.Bbamem.2017.01.020  0.327
2017 Troeira Henriques S, Craik DJ. Cyclotide Structure and Function: The Role of Membrane Binding and Permeation. Biochemistry. 56: 669-682. PMID 28085267 DOI: 10.1021/Acs.Biochem.6B01212  0.37
2017 Swedberg JE, Li CY, de Veer SJ, Wang CK, Craik DJ. Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold. Journal of Medicinal Chemistry. PMID 28045523 DOI: 10.1021/Acs.Jmedchem.6B01509  0.312
2017 Qu H, Smithies BJ, Durek T, Craik DJ. Synthesis and protein engineering applications of cyclotides Australian Journal of Chemistry. 70: 152-161. DOI: 10.1071/Ch16589  0.437
2016 Matsuura HN, Poth AG, Yendo AC, Fett-Neto AG, Craik DJ. Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids. Journal of Natural Products. 79: 3006-3013. PMID 28006906 DOI: 10.1021/Acs.Jnatprod.6B00492  0.337
2016 Craik DJ, Wang CK. Forward for ICCP2015 issue of Biopolymers Peptide Science. Biopolymers. 106: 772-773. PMID 27878993 DOI: 10.1002/Bip.22989  0.403
2016 Pinto MF, Silva ON, Viana JC, Porto WF, Migliolo L, B da Cunha N, Gomes N, Fensterseifer IC, Colgrave ML, Craik DJ, Dias SC, Franco OL. Characterization of a Bioactive Acyclotide from Palicourea rigida. Journal of Natural Products. PMID 27809507 DOI: 10.1021/Acs.Jnatprod.6B00270  0.302
2016 Chan LY, Craik DJ, Daly NL. Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Scientific Reports. 6: 35347. PMID 27734947 DOI: 10.1038/Srep35347  0.355
2016 White AM, Craik DJ. Discovery and Optimization of Peptide Macrocycles. Expert Opinion On Drug Discovery. PMID 27718641 DOI: 10.1080/17460441.2016.1245720  0.455
2016 Elliott AG, Franke B, Armstrong DA, Craik DJ, Mylne JS, Rosengren KJ. Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids. PMID 27695949 DOI: 10.1007/S00726-016-2333-X  0.496
2016 Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, ... ... Craik DJ, et al. Accurate de novo design of hyperstable constrained peptides. Nature. PMID 27626386 DOI: 10.1038/Nature19791  0.453
2016 Daly NL, Gunasekera S, Clark RJ, Lin F, Wade JD, Anderson MA, Craik DJ. The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured. Biopolymers. PMID 27564841 DOI: 10.1002/Bip.22977  0.375
2016 Craik DJ, Shim YY, Göransson U, Moss GP, Tan N, Jadhav PD, Shen J, Reaney MJ. Nomenclature of Homodetic Cyclic Peptides Produced from Ribosomal Precursors: An IUPAC Task Group Interim Report. Biopolymers. PMID 27554762 DOI: 10.1002/Bip.22939  0.645
2016 Bleackley MR, Payne JA, Hayes BM, Durek T, Craik DJ, Shafee TM, Poon IK, Hulett MD, van der Weerden NL, Anderson MA. Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant. Antimicrobial Agents and Chemotherapy. PMID 27503651 DOI: 10.1128/Aac.01479-16  0.347
2016 Verbandt S, Henriques ST, Spincemaille P, Harvey PJ, Chandhok G, Sauer V, Coninck B, Cassiman D, Craik DJ, Cammue BP, Cremer K, Thevissen K. Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells. Mechanisms of Ageing and Development. PMID 27491841 DOI: 10.1016/J.Mad.2016.07.013  0.361
2016 Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ. Structural and functional characterisation of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers. PMID 27487329 DOI: 10.1002/Bip.22927  0.398
2016 Niyomploy P, Chan LY, Poth AG, Colgrave ML, Sangvanich P, Craik DJ. Discovery, isolation and structural characterization of cyclotides from Viola sumatrana Miq. Biopolymers. PMID 27403748 DOI: 10.1002/Bip.22914  0.401
2016 Sable R, Durek T, Taneja V, Craik DJ, Pallerla S, Gauthier T, Jois S. Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein interaction. Acs Chemical Biology. PMID 27337048 DOI: 10.1021/Acschembio.6B00486  0.372
2016 Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes is a Prerequisite for its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. The Journal of Biological Chemistry. PMID 27311819 DOI: 10.1074/Jbc.M116.729095  0.34
2016 Philippe G, Huang YH, Cheneval O, Lawrence N, Zhang Z, Fairlie DP, Craik DJ, de Araujo AD, Henriques ST. Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers. PMID 27287767 DOI: 10.1002/Bip.22893  0.36
2016 Swedberg JE, Schroeder CI, Mitchell J, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ. Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency, α-helicity and reveal interactions vital for cAMP signaling in vitro. The Journal of Biological Chemistry. PMID 27226591 DOI: 10.1074/Jbc.M116.724542  0.443
2016 Weidmann J, Craik DJ. Discovery, structure, function, and applications of cyclotides: circular proteins from plants. Journal of Experimental Botany. PMID 27222514 DOI: 10.1093/Jxb/Erw210  0.377
2016 Wang CK, Craik DJ. Cyclic peptide oral bioavailability: Lessons from the past. Biopolymers. PMID 27178381 DOI: 10.1002/Bip.22878  0.415
2016 Kwon S, Bosmans F, Kaas Q, Cheneval O, Conibear AC, Rosengren KJ, Wang CK, Schroeder CI, Craik DJ. Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering. PMID 27093300 DOI: 10.1002/Bit.25993  0.472
2016 Wang CK, King GJ, Conibear AC, Ramos MC, Chaousis S, Henriques ST, Craik DJ. Mirror images of antimicrobial peptides provides reflections on their functions and amyloidogenic properties. Journal of the American Chemical Society. PMID 27064294 DOI: 10.1021/Jacs.6B02575  0.455
2016 Carstens BB, Swedberg J, Berecki G, Adams DJ, Craik DJ, Clark RJ. Effects of linker sequence modifications on the structure, stability and biological activity of a cyclic α-conotoxin. Biopolymers. PMID 27038328 DOI: 10.1002/Bip.22848  0.553
2016 Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I. Development of a μO-conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Target NaV1.8. The Journal of Biological Chemistry. PMID 27026701 DOI: 10.1074/Jbc.M116.721662  0.312
2016 Carstens BB, Berecki G, Daniel JT, Lee HS, Jackson KA, Tae HS, Sadeghi M, Castro J, O'Donnell T, Deiteren A, Brierley SM, Craik DJ, Adams DJ, Clark RJ. Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie (International Ed. in English). PMID 26948522 DOI: 10.1002/Anie.201600297  0.519
2016 Wang CK, Stalmans S, De Spiegeleer B, Craik DJ. Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26929247 DOI: 10.1002/Psc.2862  0.411
2016 Castro J, Harrington AM, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM. α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut. PMID 26887818 DOI: 10.1136/Gutjnl-2015-310971  0.447
2016 Deplazes E, Henriques ST, Smith JJ, King GF, Craik DJ, Mark AE, Schroeder CI. Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating. Biochimica Et Biophysica Acta. PMID 26850736 DOI: 10.1016/J.Bbamem.2016.02.002  0.341
2016 Wang CK, Northfield SE, Huang YH, Ramos MC, Craik DJ. Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry. 109: 342-349. PMID 26807864 DOI: 10.1016/J.Ejmech.2016.01.006  0.446
2016 Henriques ST, Craik DJ, Schroeder CI. Structure-Activity Relationship Studies Reveal that the Spider Toxin Protx-II has Unusual Membrane-Binding Properties and Inhibits NAV1.7 Channel at the Membrane Surface Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.477  0.348
2016 Huang YH, Henriques ST, Lawrence N, Kaas Q, Craik DJ. Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562 Journal of Peptide Science. 22. DOI: 10.1002/Psc.2950  0.34
2016 Wu X, Huang Y, Kaas Q, Craik DJ. Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications European Journal of Organic Chemistry. 2016: 3462-3472. DOI: 10.1002/Ejoc.201600402  0.402
2015 Dsouza C, Henriques ST, Wang CK, Cheneval O, Chan LY, Bokil NJ, Sweet MJ, Craik DJ. Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry. PMID 26685975 DOI: 10.1021/Acs.Biochem.5B00529  0.414
2015 Harris KS, Durek T, Kaas Q, Poth AG, Gilding EK, Conlan BF, Saska I, Daly NL, van der Weerden NL, Craik DJ, Anderson MA. Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications. 6: 10199. PMID 26680698 DOI: 10.1038/Ncomms10199  0.456
2015 Gilding EK, Jackson MA, Poth AG, Henriques ST, Prentis PJ, Mahatmanto T, Craik DJ. Gene coevolution and regulation lock cyclic plant defence peptides to their targets. The New Phytologist. PMID 26668107 DOI: 10.1111/Nph.13789  0.404
2015 Wang CK, Swedberg JE, Northfield SE, Craik DJ. On the Effect of Cyclization on Peptide Backbone Dynamics. The Journal of Physical Chemistry. B. PMID 26633076 DOI: 10.1021/Acs.Jpcb.5B11085  0.41
2015 Vriens K, Cools TL, Harvey PJ, Craik DJ, Braem A, Vleugels J, Coninck B, Cammue BP, Thevissen K. The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms. Peptides. PMID 26592804 DOI: 10.1016/J.Peptides.2015.11.001  0.38
2015 Burman R, Yeshak MY, Larsson S, Craik DJ, Rosengren KJ, Göransson U. Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science. 6: 855. PMID 26579135 DOI: 10.3389/Fpls.2015.00855  0.596
2015 Conibear AC, Chaousis S, Durek T, Rosengren KJ, Craik DJ, Schroeder CI. Approaches to the stabilisation of bioactive epitopes by grafting and peptide cyclisation. Biopolymers. PMID 26566734 DOI: 10.1002/Bip.22767  0.466
2015 Chan LY, Craik DJ, Daly NL. Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Bioscience Reports. PMID 26464514 DOI: 10.1042/Bsr20150210  0.385
2015 Ojeda PG, Wang CK, Craik DJ. Chlorotoxin: Structure, activity and potential uses in cancer therapy. Biopolymers. PMID 26418522 DOI: 10.1002/Bip.22748  0.325
2015 de Veer SJ, Wang CK, Harris JM, Craik DJ, Swedberg JE. Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library. Journal of Medicinal Chemistry. 58: 8257-68. PMID 26393374 DOI: 10.1021/Acs.Jmedchem.5B01148  0.311
2015 Swedberg JE, Schroeder CI, Mitchell JM, Durek T, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Liras S, Price DA, Craik DJ. Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry. 103: 175-184. PMID 26352676 DOI: 10.1016/J.Ejmech.2015.08.046  0.389
2015 Ravipati AS, Henriques ST, Poth AG, Kaas Q, Wang CK, Colgrave ML, Craik DJ. Lysine-rich cyclotides: a new subclass of circular knotted proteins from Violaceae. Acs Chemical Biology. PMID 26322745 DOI: 10.1021/Acschembio.5B00454  0.318
2015 Yu R, Seymour VA, Berecki G, Jia X, Akcan M, Adams DJ, Kaas Q, Craik DJ. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports. 5: 13264. PMID 26290113 DOI: 10.1038/Srep13264  0.509
2015 Henriques ST, Huang YH, Chaousis S, Sani MA, Poth AG, Separovic F, Craik DJ. The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chemistry & Biology. 22: 1087-97. PMID 26278183 DOI: 10.1016/J.Chembiol.2015.07.012  0.374
2015 Vriens K, Cools TL, Harvey PJ, Craik DJ, Spincemaille P, Cassiman D, Braem A, Vleugels J, Nibbering PH, Drijfhout JW, De Coninck B, Cammue BP, Thevissen K. Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures. Plos One. 10: e0132701. PMID 26248029 DOI: 10.1371/Journal.Pone.0132701  0.401
2015 Himeno K, Rosengren KJ, Inoue T, Perez RH, Colgrave ML, Lee HS, Chan LY, Henriques ST, Fujita K, Ishibashi N, Zendo T, Wilaipun P, Nakayama J, Leelawatcharamas V, Jikuya H, ... Craik DJ, et al. Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry. 54: 4863-76. PMID 26174911 DOI: 10.1021/Acs.Biochem.5B00196  0.374
2015 Akcan M, Clark RJ, Daly NL, Conibear AC, de Faoite A, Heghinian MD, Sahil T, Adams DJ, Marí F, Craik DJ. Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers. PMID 26172377 DOI: 10.1002/Bip.22699  0.572
2015 Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, ... Craik DJ, et al. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proceedings of the National Academy of Sciences of the United States of America. 112: E4026-35. PMID 26170295 DOI: 10.1073/Pnas.1503617112  0.392
2015 Kaas Q, Craik DJ. Bioinformatics-Aided Venomics. Toxins. 7: 2159-87. PMID 26110505 DOI: 10.3390/Toxins7062159  0.307
2015 Durek T, Craik DJ. Therapeutic conotoxins: a US patent literature survey. Expert Opinion On Therapeutic Patents. 1-15. PMID 26065897 DOI: 10.1517/13543776.2015.1054095  0.355
2015 De Veer SJ, Swedberg JE, Akcan M, Rosengren KJ, Brattsand M, Craik DJ, Harris JM. Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. The Biochemical Journal. PMID 25981970 DOI: 10.1042/Bj20150412  0.347
2015 Wang CK, Northfield SE, Swedberg JE, Colless B, Chaousis S, Price DA, Liras S, Craik DJ. Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability. European Journal of Medicinal Chemistry. 97: 202-13. PMID 25974856 DOI: 10.1016/J.Ejmech.2015.04.049  0.456
2015 Bernath-Levin K, Nelson C, Elliott AG, Jayasena AS, Millar AH, Craik DJ, Mylne JS. Peptide macrocyclization by a bifunctional endoprotease. Chemistry & Biology. 22: 571-82. PMID 25960260 DOI: 10.1016/J.Chembiol.2015.04.010  0.443
2015 Zhang J, Li J, Huang Z, Yang B, Zhang X, Li D, Craik DJ, Baker AJ, Shu W, Liao B. Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of Plant Physiology. 178: 17-26. PMID 25756919 DOI: 10.1016/J.Jplph.2015.01.017  0.318
2015 Huang YH, Chaousis S, Cheneval O, Craik DJ, Henriques ST. Optimization of the cyclotide framework to improve cell penetration properties. Frontiers in Pharmacology. 6: 17. PMID 25709580 DOI: 10.3389/Fphar.2015.00017  0.401
2015 Malik U, Silva ON, Fensterseifer IC, Chan LY, Clark RJ, Franco OL, Daly NL, Craik DJ. In vivo efficacy of anuran trypsin inhibitory peptides against staphylococcal skin infection and the impact of peptide cyclization. Antimicrobial Agents and Chemotherapy. 59: 2113-21. PMID 25624332 DOI: 10.1128/Aac.04324-14  0.44
2015 Haugaard-Kedström LM, Hossain MA, Daly NL, Bathgate RA, Rinderknecht E, Wade JD, Craik DJ, Rosengren KJ. Solution structure, aggregation behavior, and flexibility of human relaxin-2. Acs Chemical Biology. 10: 891-900. PMID 25547165 DOI: 10.1021/Cb500918V  0.374
2015 Mahatmanto T, Mylne JS, Poth AG, Swedberg JE, Kaas Q, Schaefer H, Craik DJ. The evolution of Momordica cyclic peptides. Molecular Biology and Evolution. 32: 392-405. PMID 25376175 DOI: 10.1093/Molbev/Msu307  0.466
2015 Craik DJ. Overview on the discovery and applications of cyclotides Advances in Botanical Research. 76: 1-13. DOI: 10.1016/Bs.Abr.2015.09.008  0.428
2014 Wang CK, Northfield SE, Colless B, Chaousis S, Hamernig I, Lohman RJ, Nielsen DS, Schroeder CI, Liras S, Price DA, Fairlie DP, Craik DJ. Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America. 111: 17504-9. PMID 25416591 DOI: 10.1073/Pnas.1417611111  0.431
2014 Ojeda PG, Chan LY, Poth AG, Wang CK, Craik DJ. The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry. 6: 1617-28. PMID 25406003 DOI: 10.4155/Fmc.14.93  0.403
2014 Conibear AC, Wang CK, Bi T, Rosengren KJ, Camarero JA, Craik DJ. Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis. The Journal of Physical Chemistry. B. 118: 14257-66. PMID 25375365 DOI: 10.1021/Jp507754C  0.374
2014 Hill TA, Lohman RJ, Hoang HN, Nielsen DS, Scully CC, Kok WM, Liu L, Lucke AJ, Stoermer MJ, Schroeder CI, Chaousis S, Colless B, Bernhardt PV, Edmonds DJ, Griffith DA, ... ... Craik DJ, et al. Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed. Acs Medicinal Chemistry Letters. 5: 1148-51. PMID 25313329 DOI: 10.1021/Ml5002823  0.413
2014 Nielsen DS, Hoang HN, Lohman RJ, Hill TA, Lucke AJ, Craik DJ, Edmonds DJ, Griffith DA, Rotter CJ, Ruggeri RB, Price DA, Liras S, Fairlie DP. Improving on nature: making a cyclic heptapeptide orally bioavailable. Angewandte Chemie (International Ed. in English). 53: 12059-63. PMID 25219505 DOI: 10.1002/Anie.201405364  0.38
2014 Wang CK, Northfield SE, Swedberg JE, Harvey PJ, Mathiowetz AM, Price DA, Liras S, Craik DJ. Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. The Journal of Physical Chemistry. B. 118: 11129-36. PMID 25184622 DOI: 10.1021/Jp506678F  0.392
2014 Vink S, Daly NL, Steen N, Craik DJ, Alewood PF. Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus. Toxicon : Official Journal of the International Society On Toxinology. 90: 308-17. PMID 25172536 DOI: 10.1016/J.Toxicon.2014.08.068  0.311
2014 Wang CK, King GJ, Northfield SE, Ojeda PG, Craik DJ. Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie (International Ed. in English). 53: 11236-41. PMID 25168664 DOI: 10.1002/Anie.201406563  0.441
2014 Conibear AC, Craik DJ. The chemistry and biology of theta defensins. Angewandte Chemie (International Ed. in English). 53: 10612-23. PMID 25079086 DOI: 10.1002/Anie.201402167  0.437
2014 D'Souza C, Henriques ST, Wang CK, Craik DJ. Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry. 88: 10-8. PMID 24985034 DOI: 10.1016/J.Ejmech.2014.06.047  0.432
2014 Cheneval O, Schroeder CI, Durek T, Walsh P, Huang YH, Liras S, Price DA, Craik DJ. Fmoc-based synthesis of disulfide-rich cyclic peptides. The Journal of Organic Chemistry. 79: 5538-44. PMID 24918986 DOI: 10.1021/Jo500699M  0.448
2014 Delattin N, De Brucker K, Craik DJ, Cheneval O, De Coninck B, Cammue BP, Thevissen K. Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation. Antimicrobial Agents and Chemotherapy. 58: 4974-7. PMID 24913176 DOI: 10.1128/Aac.03336-14  0.332
2014 Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Discovery, synthesis, and structure-activity relationships of conotoxins. Chemical Reviews. 114: 5815-47. PMID 24720541 DOI: 10.1021/Cr400401E  0.336
2014 Elliott AG, Delay C, Liu H, Phua Z, Rosengren KJ, Benfield AH, Panero JL, Colgrave ML, Jayasena AS, Dunse KM, Anderson MA, Schilling EE, Ortiz-Barrientos D, Craik DJ, Mylne JS. Evolutionary origins of a bioactive peptide buried within Preproalbumin. The Plant Cell. 26: 981-95. PMID 24681618 DOI: 10.1105/Tpc.114.123620  0.469
2014 Northfield SE, Wang CK, Schroeder CI, Durek T, Kan MW, Swedberg JE, Craik DJ. Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry. 77: 248-57. PMID 24650712 DOI: 10.1016/J.Ejmech.2014.03.011  0.46
2014 Berecki G, Daly NL, Huang YH, Vink S, Craik DJ, Alewood PF, Adams DJ. Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. British Journal of Pharmacology. 171: 3313-27. PMID 24628243 DOI: 10.1111/Bph.12686  0.388
2014 Mahatmanto T, Poth AG, Mylne JS, Craik DJ. A comparative study of extraction methods reveals preferred solvents for cystine knot peptide isolation from Momordica cochinchinensis seeds. Fitoterapia. 95: 22-33. PMID 24613804 DOI: 10.1016/J.Fitote.2014.02.016  0.348
2014 Lay FT, Poon S, McKenna JA, Connelly AA, Barbeta BL, McGinness BS, Fox JL, Daly NL, Craik DJ, Heath RL, Anderson MA. The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions. Bmc Plant Biology. 14: 41. PMID 24495600 DOI: 10.1186/1471-2229-14-41  0.31
2014 Schroeder CI, Swedberg JE, Withka JM, Rosengren KJ, Akcan M, Clayton DJ, Daly NL, Cheneval O, Borzilleri KA, Griffor M, Stock I, Colless B, Walsh P, Sunderland P, Reyes A, ... ... Craik DJ, et al. Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry & Biology. 21: 284-94. PMID 24440079 DOI: 10.1016/J.Chembiol.2013.11.014  0.337
2014 Jia X, Kwon S, Wang CI, Huang YH, Chan LY, Tan CC, Rosengren KJ, Mulvenna JP, Schroeder CI, Craik DJ. Semienzymatic cyclization of disulfide-rich peptides using Sortase A. The Journal of Biological Chemistry. 289: 6627-38. PMID 24425873 DOI: 10.1074/Jbc.M113.539262  0.474
2014 Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P. A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 1842-53. PMID 24398291 DOI: 10.1096/Fj.13-244103  0.307
2014 Conibear AC, Bochen A, Rosengren KJ, Stupar P, Wang C, Kessler H, Craik DJ. The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif. Chembiochem : a European Journal of Chemical Biology. 15: 451-9. PMID 24382674 DOI: 10.1002/Cbic.201300568  0.462
2014 Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T. Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie (International Ed. in English). 53: 1017-20. PMID 24323786 DOI: 10.1002/Anie.201308898  0.423
2014 Wang CK, Gruber CW, Cemazar M, Siatskas C, Tagore P, Payne N, Sun G, Wang S, Bernard CC, Craik DJ. Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. Acs Chemical Biology. 9: 156-63. PMID 24147816 DOI: 10.1021/Cb400548S  0.398
2014 Kedarisetti P, Mizianty MJ, Kaas Q, Craik DJ, Kurgan L. Prediction and characterization of cyclic proteins from sequences in three domains of life. Biochimica Et Biophysica Acta. 1844: 181-90. PMID 23669569 DOI: 10.1016/J.Bbapap.2013.05.002  0.373
2014 Harrington AM, Castro J, Garcia-Caraballo S, Maddern J, Craik D, Adams DJ, Brierley SM. 888 α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain Gastroenterology. 146: S-156. DOI: 10.1016/S0016-5085(14)60555-2  0.383
2014 Taylor CM, Northfield SE, Wang CK, Craik DJ. Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1 Tetrahedron. 70: 7669-7674. DOI: 10.1016/J.Tet.2014.06.058  0.455
2014 Conibear AC, Craik DJ. Chemie und Biologie von Theta‐Defensinen Angewandte Chemie. 126: 10786-10798. DOI: 10.1002/Ange.201402167  0.366
2013 Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America. 110: 21183-8. PMID 24248349 DOI: 10.1073/Pnas.1311183110  0.452
2013 Luo S, Zhangsun D, Zhu X, Wu Y, Hu Y, Christensen S, Harvey PJ, Akcan M, Craik DJ, McIntosh JM. Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 56: 9655-63. PMID 24200193 DOI: 10.1021/Jm401254C  0.344
2013 Daly NL, Thorstholm L, Greenwood KP, King GJ, Rosengren KJ, Heras B, Martin JL, Craik DJ. Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. The Journal of Biological Chemistry. 288: 36141-8. PMID 24169696 DOI: 10.1074/Jbc.M113.528240  0.438
2013 He WJ, Chan LY, Clark RJ, Tang J, Zeng GZ, Franco OL, Cantacessi C, Craik DJ, Daly NL, Tan NH. Novel inhibitor cystine knot peptides from Momordica charantia. Plos One. 8: e75334. PMID 24116036 DOI: 10.1371/Journal.Pone.0075334  0.474
2013 Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 34428-42. PMID 24100032 DOI: 10.1074/Jbc.M113.512582  0.468
2013 Craik DJ. Foreword for ICCP2012 issue of Biopolymers Peptide Science Circular Proteins: Never ending possibilities. Biopolymers. 100: iii-v. PMID 24078182 DOI: 10.1002/Bip.22366  0.415
2013 De Coninck B, Carron D, Tavormina P, Willem L, Craik DJ, Vos C, Thevissen K, Mathys J, Cammue BP. Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance. Journal of Experimental Botany. 64: 5297-307. PMID 24043855 DOI: 10.1093/Jxb/Ert295  0.403
2013 Torcato IM, Huang YH, Franquelim HG, Gaspar DD, Craik DJ, Castanho MA, Henriques ST. The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability. Chembiochem : a European Journal of Chemical Biology. 14: 2013-22. PMID 24038773 DOI: 10.1002/Cbic.201300274  0.303
2013 Schroeder CI, Swedberg JE, Craik DJ. Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides. Current Protein & Peptide Science. 14: 532-42. PMID 23968348 DOI: 10.2174/13892037113149990069  0.426
2013 Akcan M, Craik DJ. Synthesis of cyclic disulfide-rich peptides. Methods in Molecular Biology (Clifton, N.J.). 1047: 89-101. PMID 23943480 DOI: 10.1007/978-1-62703-544-6_6  0.451
2013 Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/J.Bcp.2013.07.016  0.488
2013 Gerlach SL, Göransson U, Kaas Q, Craik DJ, Mondal D, Gruber CW. A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis. Biopolymers. 100: 433-7. PMID 23907794 DOI: 10.1002/Bip.22258  0.611
2013 Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers. 100: 519-26. PMID 23897622 DOI: 10.1002/Bip.22350  0.43
2013 Poth AG, Chan LY, Craik DJ. Cyclotides as grafting frameworks for protein engineering and drug design applications. Biopolymers. 100: 480-91. PMID 23893608 DOI: 10.1002/Bip.22284  0.38
2013 Rosengren KJ, Daly NL, Harvey PJ, Craik DJ. The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions. Biopolymers. 100: 453-60. PMID 23893463 DOI: 10.1002/Bip.22269  0.324
2013 Gründemann C, Thell K, Lengen K, Garcia-Käufer M, Huang YH, Huber R, Craik DJ, Schabbauer G, Gruber CW. Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. Plos One. 8: e68016. PMID 23840803 DOI: 10.1371/Journal.Pone.0068016  0.318
2013 Craik DJ, Malik U. Cyclotide biosynthesis. Current Opinion in Chemical Biology. 17: 546-54. PMID 23809361 DOI: 10.1016/j.cbpa.2013.05.033  0.335
2013 Craik DJ. Joseph Rudinger memorial lecture: discovery and applications of cyclotides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 19: 393-407. PMID 23737440 DOI: 10.1002/Psc.2523  0.404
2013 Gao B, Harvey PJ, Craik DJ, Ronjat M, De Waard M, Zhu S. Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold. Bioscience Reports. 33. PMID 23721518 DOI: 10.1042/Bsr20130052  0.365
2013 Garvey M, Meehan S, Gras SL, Schirra HJ, Craik DJ, Van der Weerden NL, Anderson MA, Gerrard JA, Carver JA. A radish seed antifungal peptide with a high amyloid fibril-forming propensity. Biochimica Et Biophysica Acta. 1834: 1615-23. PMID 23665069 DOI: 10.1016/J.Bbapap.2013.04.030  0.434
2013 Kaas Q, Craik DJ. NMR of plant proteins. Progress in Nuclear Magnetic Resonance Spectroscopy. 71: 1-34. PMID 23611313 DOI: 10.1016/J.Pnmrs.2013.01.003  0.333
2013 Yu R, Kompella SN, Adams DJ, Craik DJ, Kaas Q. Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 56: 3557-67. PMID 23566299 DOI: 10.1021/Jm400041H  0.403
2013 Cowper B, Craik DJ, Macmillan D. Making ends meet: chemically mediated circularization of recombinant proteins. Chembiochem : a European Journal of Chemical Biology. 14: 809-12. PMID 23559418 DOI: 10.1002/Cbic.201300105  0.399
2013 Quimbar P, Malik U, Sommerhoff CP, Kaas Q, Chan LY, Huang YH, Grundhuber M, Dunse K, Craik DJ, Anderson MA, Daly NL. High-affinity cyclic peptide matriptase inhibitors. The Journal of Biological Chemistry. 288: 13885-96. PMID 23548907 DOI: 10.1074/Jbc.M113.460030  0.417
2013 Getz JA, Cheneval O, Craik DJ, Daugherty PS. Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration. Acs Chemical Biology. 8: 1147-54. PMID 23537207 DOI: 10.1021/Cb4000585  0.415
2013 Akcan M, Cao Y, Chongxu F, Craik DJ. The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorganic & Medicinal Chemistry. 21: 3590-6. PMID 23490156 DOI: 10.1016/J.Bmc.2013.02.012  0.358
2013 Malagón D, Botterill B, Gray DJ, Lovas E, Duke M, Gray C, Kopp SR, Knott LM, McManus DP, Daly NL, Mulvenna J, Craik DJ, Jones MK. Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites. Biopolymers. 100: 461-70. PMID 23468118 DOI: 10.1002/Bip.22229  0.327
2013 Conibear AC, Rosengren KJ, Daly NL, Henriques ST, Craik DJ. The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity. The Journal of Biological Chemistry. 288: 10830-40. PMID 23430740 DOI: 10.1074/Jbc.M113.451047  0.483
2013 Chan LY, Zhang VM, Huang YH, Waters NC, Bansal PS, Craik DJ, Daly NL. Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity. Chembiochem : a European Journal of Chemical Biology. 14: 617-24. PMID 23426877 DOI: 10.1002/Cbic.201300034  0.447
2013 Craik DJ, Schroeder CI. Peptides from mamba venom as pain killers. Angewandte Chemie (International Ed. in English). 52: 3071-3. PMID 23382094 DOI: 10.1002/Anie.201209851  0.433
2013 Craik DJ, Fairlie DP, Liras S, Price D. The future of peptide-based drugs. Chemical Biology & Drug Design. 81: 136-47. PMID 23253135 DOI: 10.1111/Cbdd.12055  0.36
2013 Torcato IM, Huang YH, Franquelim HG, Gaspar D, Craik DJ, Castanho MA, Troeira Henriques S. Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochimica Et Biophysica Acta. 1828: 944-55. PMID 23246973 DOI: 10.1016/J.Bbamem.2012.12.002  0.385
2013 Luo S, Zhangsun D, Wu Y, Zhu X, Hu Y, McIntyre M, Christensen S, Akcan M, Craik DJ, McIntosh JM. Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 894-902. PMID 23184959 DOI: 10.1074/Jbc.M112.427898  0.329
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.627
2013 Chan LY, He W, Tan N, Zeng G, Craik DJ, Daly NL. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides. 39: 29-35. PMID 23127518 DOI: 10.1016/J.Peptides.2012.09.018  0.453
2013 Adams DJ, Berecki G, Clark R, Craik DJ. Development of analgesic alpha-conotoxins for treatment of chronic pain Clinical and Experimental Pharmacology and Physiology. 40: 4-4. DOI: 10.1111/1440-1681.12170  0.365
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.611
2013 Craik DJ, Schroeder CI. Peptide aus Mambagift als Schmerzmittel Angewandte Chemie. 125: 3149-3151. DOI: 10.1002/Ange.201209851  0.366
2012 Conibear AC, Daly NL, Craik DJ. Quantification of small cyclic disulfide-rich peptides. Biopolymers. 98: 518-24. PMID 23203757 DOI: 10.1002/Bip.22121  0.447
2012 Schroeder CI, Nielsen KJ, Adams DA, Loughnan M, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers. 98: 345-56. PMID 23193599 DOI: 10.1002/Bip.22031  0.358
2012 Conibear AC, Rosengren KJ, Harvey PJ, Craik DJ. Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry. 51: 9718-26. PMID 23148585 DOI: 10.1021/Bi301363A  0.434
2012 Craik DJ, Henriques ST, Mylne JS, Wang CK. Cyclotide isolation and characterization. Methods in Enzymology. 516: 37-62. PMID 23034223 DOI: 10.1016/B978-0-12-394291-3.00024-1  0.46
2012 Eliasen R, Daly NL, Wulff BS, Andresen TL, Conde-Frieboes KW, Craik DJ. Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. The Journal of Biological Chemistry. 287: 40493-501. PMID 23012369 DOI: 10.1074/Jbc.M112.395442  0.444
2012 Henriques ST, Huang YH, Castanho MA, Bagatolli LA, Sonza S, Tachedjian G, Daly NL, Craik DJ. Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions. The Journal of Biological Chemistry. 287: 33629-43. PMID 22854971 DOI: 10.1074/Jbc.M112.372011  0.376
2012 Cemazar M, Kwon S, Mahatmanto T, Ravipati AS, Craik DJ. Discovery and applications of disulfide-rich cyclic peptides. Current Topics in Medicinal Chemistry. 12: 1534-45. PMID 22827522 DOI: 10.2174/156802612802652484  0.465
2012 Mylne JS, Chan LY, Chanson AH, Daly NL, Schaefer H, Bailey TL, Nguyencong P, Cascales L, Craik DJ. Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis. The Plant Cell. 24: 2765-78. PMID 22822203 DOI: 10.1105/Tpc.112.099085  0.459
2012 Schroeder CI, Craik DJ. Therapeutic potential of conopeptides. Future Medicinal Chemistry. 4: 1243-55. PMID 22800369 DOI: 10.4155/Fmc.12.70  0.422
2012 Poth AG, Mylne JS, Grassl J, Lyons RE, Millar AH, Colgrave ML, Craik DJ. Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae). The Journal of Biological Chemistry. 287: 27033-46. PMID 22700981 DOI: 10.1074/Jbc.M112.370841  0.384
2012 Craik DJ, Allewell NM. Thematic minireview series on circular proteins. The Journal of Biological Chemistry. 287: 26999-7000. PMID 22700978 DOI: 10.1074/Jbc.R112.390344  0.422
2012 Conlan BF, Colgrave ML, Gillon AD, Guarino R, Craik DJ, Anderson MA. Insights into processing and cyclization events associated with biosynthesis of the cyclic Peptide kalata B1. The Journal of Biological Chemistry. 287: 28037-46. PMID 22700963 DOI: 10.1074/Jbc.M112.347823  0.412
2012 Zhu S, Gao B, Harvey PJ, Craik DJ. Dermatophytic defensin with antiinfective potential. Proceedings of the National Academy of Sciences of the United States of America. 109: 8495-500. PMID 22586077 DOI: 10.1073/Pnas.1201263109  0.4
2012 Craik DJ. Host-defense activities of cyclotides. Toxins. 4: 139-56. PMID 22474571 DOI: 10.3390/Toxins4020139  0.402
2012 Craik DJ, Swedberg JE, Mylne JS, Cemazar M. Cyclotides as a basis for drug design. Expert Opinion On Drug Discovery. 7: 179-94. PMID 22468950 DOI: 10.1517/17460441.2012.661554  0.437
2012 Andersson HS, Figueredo SM, Haugaard-Kedström LM, Bengtsson E, Daly NL, Qu X, Craik DJ, Ouellette AJ, Rosengren KJ. The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids. 43: 1471-83. PMID 22286872 DOI: 10.1007/S00726-012-1220-3  0.442
2012 Clark RJ, Craik DJ. Engineering cyclic peptide toxins Methods in Enzymology. 503: 57-74. PMID 22230565 DOI: 10.1016/B978-0-12-396962-0.00003-3  0.465
2012 Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochemical Pharmacology. 83: 419-26. PMID 22108175 DOI: 10.1016/J.Bcp.2011.11.006  0.475
2012 Pinto MFS, Fensterseifer ICM, Migliolo L, Sousa DA, De Capdville G, Arboleda-Valencia JW, Colgrave ML, Craik DJ, Magalhães BS, Dias SC, Franco OL. Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane Journal of Biological Chemistry. 287: 134-147. PMID 22074926 DOI: 10.1074/Jbc.M111.294009  0.455
2012 Clark RJ, Akcan M, Kaas Q, Daly NL, Craik DJ. Cyclization of conotoxins to improve their biopharmaceutical properties Toxicon. 59: 446-455. PMID 21147143 DOI: 10.1016/J.Toxicon.2010.12.003  0.383
2012 Franco A, Heighinian M, Mejia M, McCall J, Nag S, Akondi K, Melaun C, Daly N, Luetje CW, Alewood PF, Craik DJ, Godenschwege T, Adams DJ, Marí F. 105. Discovery, Characterization, and Functional Implications of Conotoxins from Cone Snails Species of the Americas Toxicon. 60: 148. DOI: 10.1016/J.Toxicon.2012.04.106  0.377
2012 Thorstholm L, Craik DJ. Discovery and applications of naturally occurring cyclic peptides Drug Discovery Today: Technologies. 9: e13-e21. DOI: 10.1016/J.Ddtec.2011.07.005  0.427
2011 Carstens BB, Clark RJ, Daly NL, Harvey PJ, Kaas Q, Craik DJ. Engineering of Conotoxins for the Treatment of Pain Current Pharmaceutical Design. 17: 4242-4253. PMID 22204425 DOI: 10.2174/138161211798999401  0.358
2011 Chan LY, Gunasekera S, Henriques ST, Worth NF, Le SJ, Clark RJ, Campbell JH, Craik DJ, Daly NL. Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood. 118: 6709-17. PMID 22039263 DOI: 10.1182/Blood-2011-06-359141  0.461
2011 Smith AB, Daly NL, Craik DJ. Cyclotides: a patent review. Expert Opinion On Therapeutic Patents. 21: 1657-72. PMID 22017409 DOI: 10.1517/13543776.2011.620606  0.457
2011 Sando L, Henriques ST, Foley F, Simonsen SM, Daly NL, Hall KN, Gustafson KR, Aguilar MI, Craik DJ. A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. Chembiochem : a European Journal of Chemical Biology. 12: 2456-62. PMID 21928440 DOI: 10.1002/Cbic.201100450  0.39
2011 Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society. 133: 15866-9. PMID 21899353 DOI: 10.1021/Ja206408Q  0.408
2011 Halai R, Callaghan B, Daly NL, Clark RJ, Adams DJ, Craik DJ. Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA B receptor Journal of Medicinal Chemistry. 54: 6984-6992. PMID 21888386 DOI: 10.1021/Jm201060R  0.516
2011 Cascales L, Henriques ST, Kerr MC, Huang YH, Sweet MJ, Daly NL, Craik DJ. Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. The Journal of Biological Chemistry. 286: 36932-43. PMID 21873420 DOI: 10.1074/Jbc.M111.264424  0.425
2011 He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N. Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides. 32: 1719-23. PMID 21723349 DOI: 10.1016/J.Peptides.2011.06.016  0.46
2011 Yuan C, Chen L, Meehan EJ, Daly N, Craik DJ, Huang M, Ngo JC. Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. Bmc Structural Biology. 11: 30. PMID 21693064 DOI: 10.1186/1472-6807-11-30  0.353
2011 de Araujo AD, Callaghan B, Nevin ST, Daly NL, Craik DJ, Moretta M, Hopping G, Christie MJ, Adams DJ, Alewood PF. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Ed. in English). 50: 6527-9. PMID 21630402 DOI: 10.1002/Anie.201101642  0.52
2011 Poth AG, Colgrave ML, Lyons RE, Dalya NL, Craik DJ. Discovery of an unusual biosynthetic origin for circular proteins in legumes Proceedings of the National Academy of Sciences of the United States of America. 108: 10127-10132. PMID 21593408 DOI: 10.1073/Pnas.1103660108  0.395
2011 Craik DJ, Conibear AC. The chemistry of cyclotides Journal of Organic Chemistry. 76: 4805-4817. PMID 21526790 DOI: 10.1021/Jo200520V  0.453
2011 Wang CKL, Clark RJ, Harvey PJ, Johan Rosengren K, Cemazar M, Craik DJ. The role of conserved glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring glu to asp mutant Biochemistry. 50: 4077-4086. PMID 21466163 DOI: 10.1021/Bi2004153  0.372
2011 Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry & Biology. 18: 336-43. PMID 21439478 DOI: 10.1002/Psc.2448  0.333
2011 Mylne JS, Colgrave ML, Daly NL, Chanson AH, Elliott AG, McCallum EJ, Jones A, Craik DJ. Albumins and their processing machinery are hijacked for cyclic peptides in sunflower Nature Chemical Biology. 7: 257-259. PMID 21423169 DOI: 10.1038/Nchembio.542  0.429
2011 Yu R, Craik DJ, Kaas Q. Blockade of neuronal α7-nAchR by α-Conotoxin ImI explained by computational scanning and energy calculations Plos Computational Biology. 7. PMID 21390272 DOI: 10.1371/Journal.Pcbi.1002011  0.301
2011 Haugaard-Kedström LM, Shabanpoor F, Hossain MA, Clark RJ, Ryan PJ, Craik DJ, Gundlach AL, Wade JD, Bathgate RA, Rosengren KJ. Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society. 133: 4965-74. PMID 21384867 DOI: 10.1021/Ja110567J  0.419
2011 Daly NL, Craik DJ. Bioactive cystine knot proteins Current Opinion in Chemical Biology. 15: 362-368. PMID 21362584 DOI: 10.1016/J.Cbpa.2011.02.008  0.425
2011 Daly NL, Rosengren KJ, Troeira Henriques S, Craik DJ. NMR and protein structure in drug design: Application to cyclotides and conotoxins European Biophysics Journal. 40: 359-370. PMID 21290122 DOI: 10.1007/S00249-011-0672-9  0.419
2011 Daly NL, Callaghan B, Clark RJ, Nevin ST, Adams DJ, Craik DJ. Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Journal of Biological Chemistry. 286: 10233-10237. PMID 21252227 DOI: 10.1074/Jbc.M110.196170  0.453
2011 Akcan M, Stroud MR, Hansen SJ, Clark RJ, Daly NL, Craik DJ, Olson JM. Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. Journal of Medicinal Chemistry. 54: 782-7. PMID 21210710 DOI: 10.1021/Jm101018R  0.349
2011 Poth AG, Colgrave ML, Philip R, Kerenga B, Daly NL, Anderson MA, Craik DJ. Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins Acs Chemical Biology. 6: 345-355. PMID 21194241 DOI: 10.1021/Cb100388J  0.331
2011 Craik DJ. The folding of disulfide-rich proteins Antioxidants and Redox Signaling. 14: 61-64. PMID 20849378 DOI: 10.1089/Ars.2010.3656  0.312
2011 Lovelace ES, Gunasekera S, Alvarmo C, Clark RJ, Nevin ST, Grishin AA, Adams DJ, Craik DJ, Daly NL. Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization Antioxidants and Redox Signaling. 14: 87-95. PMID 20486767 DOI: 10.1089/Ars.2009.3068  0.535
2011 Aboye TL, Clark RJ, Burman R, Roig MB, Craik DJ, Göransson U. Interlocking disulfides in circular proteins: Toward efficient oxidative folding of cyclotides Antioxidants and Redox Signaling. 14: 77-86. PMID 20486762 DOI: 10.1089/Ars.2010.3112  0.61
2011 Daly NL, Craik DJ. Conopeptides as novel options for pain management Drugs of the Future. 36: 25-32. DOI: 10.1358/Dof.2011.36.1.1561066  0.301
2011 Koehbach J, O’Brien M, Miazzo M, Craik DJ, Freissmuth M, Gruber CW. Circular plant peptides as templates for GPCR drug discovery? Bmc Pharmacology. 11: A16. DOI: 10.1186/1471-2210-11-S2-A16  0.362
2011 Craik D, Poth A, Colgrave M, Akcan M, Oku B, Chan A, Daly N. Discovery and applications of naturally occurring cyclic peptides Planta Medica. 77. DOI: 10.1055/S-0031-1282086  0.426
2011 Adams D, Grishin A, Hung A, Clark R, Akondi K, Alewood P, Craik D. Scanning mutagenesis of α-conotoxin AuIB reveals a critical residue for activity at the α3β4 nicotinic acetylcholine receptor Biochemical Pharmacology. 82: 1028. DOI: 10.1016/J.Bcp.2011.07.017  0.41
2011 Conibear AC, Craik DJ. Chemical synthesis of naturally-occurring cyclic mini-proteins from plants and animals Israel Journal of Chemistry. 51: 908-916. DOI: 10.1002/Ijch.201100067  0.469
2010 Craik DJ. Forward for ICCP2009 issue of Biopolymers peptide science Biopolymers. 94: iii-v. PMID 21284141 DOI: 10.1002/Bip.21509  0.403
2010 Henriques ST, Tan CC, Craik DJ, Clark RJ. Structural and functional analysis of human liver-expressed antimicrobial peptide 2. Chembiochem : a European Journal of Chemical Biology. 11: 2148-57. PMID 20845358 DOI: 10.1002/Cbic.201000400  0.435
2010 Cascales L, Craik DJ. Naturally occurring circular proteins: Distribution, biosynthesis and evolution Organic and Biomolecular Chemistry. 8: 5035-5047. PMID 20835453 DOI: 10.1039/C0Ob00139B  0.409
2010 Ireland DC, Clark RJ, Daly NL, Craik DJ. Isolation, sequencing, and structure - Activity relationships of cyclotides Journal of Natural Products. 73: 1610-1622. PMID 20718473 DOI: 10.1021/Np1000413  0.438
2010 Morales RA, Daly NL, Vetter I, Mobli M, Napier IA, Craik DJ, Lewis RJ, Christie MJ, King GF, Alewood PF, Durek T. Chemical synthesis and structure of the prokineticin Bv8. Chembiochem : a European Journal of Chemical Biology. 11: 1882-8. PMID 20677202 DOI: 10.1002/Cbic.201000330  0.419
2010 Clark RJ, Craik DJ. Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins Biopolymers. 94: 414-422. PMID 20593458 DOI: 10.1002/Bip.21372  0.486
2010 Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides. 31: 1434-40. PMID 20580652 DOI: 10.1016/J.Peptides.2010.05.004  0.333
2010 Kaas Q, Craik DJ. Analysis and classification of circular proteins in CyBase Biopolymers. 94: 584-591. PMID 20564021 DOI: 10.1002/Bip.21424  0.343
2010 Conlan BF, Gillon AD, Craik DJ, Anderson MA. Circular proteins and mechanisms of cyclization Biopolymers. 94: 573-583. PMID 20564019 DOI: 10.1002/Bip.21422  0.43
2010 Mylne JS, Wang CK, van der Weerden NL, Craik DJ. Cyclotides are a component of the innate defense of Oldenlandia affinis Biopolymers. 94: 635-646. PMID 20564018 DOI: 10.1002/Bip.21419  0.346
2010 Colgrave ML, Korsinczky MJL, Clark RJ, Foley F, Craik DJ. Sunflower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs Biopolymers. 94: 665-672. PMID 20564016 DOI: 10.1002/Bip.21415  0.463
2010 Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ. Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis Biopolymers. 94: 647-658. PMID 20564013 DOI: 10.1002/Bip.21409  0.382
2010 Burman R, Svedlund E, Felth J, Hassan S, Herrmann A, Clark RJ, Craik DJ, Bohlin L, Claeson P, Göransson U, Gullbo J. Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice Biopolymers. 94: 626-634. PMID 20564012 DOI: 10.1002/Bip.21408  0.662
2010 Colgrave ML, Poth AG, Kaas Q, Craik DJ. A new "era" for cyclotide sequencing Biopolymers. 94: 592-601. PMID 20564007 DOI: 10.1002/Bip.21400  0.417
2010 Clark RJ, Jensen J, Nevin ST, Callaghan BP, Adams DJ, Craik DJ. The engineering of an orally active conotoxin for the treatment of neuropathic pain Angewandte Chemie - International Edition. 49: 6545-6548. PMID 20533477 DOI: 10.1002/Anie.201000620  0.476
2010 Craik DJ. Discovery and applications of the plant cyclotides Toxicon. 56: 1092-1102. PMID 20219513 DOI: 10.1016/J.Toxicon.2010.02.021  0.344
2010 Kaas Q, Westermann J, Craik DJ. Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon. 55: 1491-1509. PMID 20211197 DOI: 10.1016/J.Toxicon.2010.03.002  0.394
2010 Craik D. PepTalk--CHI's Ninth Annual Meeting--Engineering Protein & Peptide Therapeutics: Peptides. Idrugs : the Investigational Drugs Journal. 13: 156-8. PMID 20191429  0.337
2010 Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/Ja910602H  0.446
2010 Qin Q, McCallum EJ, Kaas Q, Suda J, Saska I, Craik DJ, Mylne JS. Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. Bmc Genomics. 11: 111. PMID 20158917 DOI: 10.1186/1471-2164-11-111  0.397
2010 Huang YH, Colgrave ML, Clark RJ, Kotze AC, Craik DJ. Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. The Journal of Biological Chemistry. 285: 10797-805. PMID 20103593 DOI: 10.1074/Jbc.M109.089854  0.365
2010 Armishaw CJ, Dutton JL, Craik DJ, Alewood PF. Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogs. Biopolymers. 94: 307-13. PMID 20013812 DOI: 10.1002/Bip.21360  0.359
2010 Burman R, Gruber CW, Rizzardi K, Herrmann A, Craik DJ, Gupta MP, Göransson U. Cyclotide proteins and precursors from the genus Gloeospermum: Filling a blank spot in the cyclotide map of Violaceae Phytochemistry. 71: 13-20. PMID 19879608 DOI: 10.1016/J.Phytochem.2009.09.023  0.619
2010 Craik DJ, Mylne JS, Daly NL. Cyclotides: macrocyclic peptides with applications in drug design and agriculture. Cellular and Molecular Life Sciences. 67: 9-16. PMID 19795188 DOI: 10.1007/S00018-009-0159-3  0.43
2010 Daly NL, Chen B, Nguyencong P, Craik DJ. Structure and Activity of the Leaf-Specific Cyclotide vhl-2 Australian Journal of Chemistry. 63: 771-778. DOI: 10.1071/Ch10007  0.431
2010 Clark R, Guille V, Callaghan B, Adams D, Craik D. 167 DEVELOPMENT OF AN ORALLY ACTIVE PEPTIDE FOR THE TREATMENT OF NEUROPATHIC PAIN European Journal of Pain Supplements. 4: 50-50. DOI: 10.1016/S1754-3207(10)70172-3  0.473
2010 Craik DJ, Huang Y, Colgrave ML, Martinac B, Keleshian A, Daly NL. Membrane Interactions and the Formation of Multimeric Pores by Cyclotides Biophysical Journal. 98: 609a. DOI: 10.1016/J.Bpj.2009.12.3318  0.356
2010 Gruber CW, Craik D, Kopp B. Discovery and distribution of circular peptides in flowering plants Journal of Peptide Science. 16: 30-30. DOI: 10.1002/Psc.1301  0.391
2010 Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N. Isolation and characterization of bioactive cyclotides from viola labridorica Helvetica Chimica Acta. 93: 2287-2295. DOI: 10.1002/Hlca.201000115  0.331
2010 Henriques ST, Tan CC, Craik DJ, Clark RJ. Cover Picture: Structural and Functional Analysis of Human Liver‐Expressed Antimicrobial Peptide 2 (ChemBioChem 15/2010) Chembiochem. 11: 2057-2057. DOI: 10.1002/Cbic.201090072  0.419
2010 Clark R, Jensen J, Nevin S, Callaghan B, Adams D, Craik D. Inside Cover: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. Int. Ed. 37/2010) Angewandte Chemie International Edition. 49: 6460-6460. DOI: 10.1002/Anie.201003933  0.368
2010 Clark R, Jensen J, Nevin S, Callaghan B, Adams D, Craik D. Innentitelbild: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. 37/2010) Angewandte Chemie. 122: 6606-6606. DOI: 10.1002/Ange.201003933  0.366
2010 Craik DJ, Smith PA, Clark RJ. NMR-Based Screening and Drug Discovery Burger's Medicinal Chemistry and Drug Discovery. 2: 359-437. DOI: 10.1002/0471266949.Bmc011.Pub2  0.301
2009 Daly NL, Craik DJ. Design and therapeutic applications of cyclotides Future Medicinal Chemistry. 1: 1613-1622. PMID 21425982 DOI: 10.4155/Fmc.09.129  0.399
2009 Rosengren KJ, Craik DJ. How bugs make lassos Chemistry & Biology. 16: 1211-1212. PMID 20064427 DOI: 10.1016/J.Chembiol.2009.12.004  0.357
2009 Wang CK, Colgrave ML, Ireland DC, Kaas Q, Craik DJ. Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal. 97: 1471-81. PMID 19720036 DOI: 10.1016/J.Bpj.2009.06.032  0.348
2009 Chan LY, Wang CK, Major JM, Greenwood KP, Lewis RJ, Craik DJ, Daly NL. Isolation and characterization of peptides from Momordica cochinchinensis seeds. Journal of Natural Products. 72: 1453-8. PMID 19711988 DOI: 10.1021/Np900174N  0.471
2009 Halai R, Craik DJ. Conotoxins: natural product drug leads Natural Product Reports. 26: 526-536. PMID 19642420 DOI: 10.1039/B819311H  0.379
2009 Huang YH, Colgrave ML, Daly NL, Keleshian A, Martinac B, Craik DJ. The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores. The Journal of Biological Chemistry. 284: 20699-707. PMID 19491108 DOI: 10.1074/Jbc.M109.003384  0.354
2009 Daly NL, Rosengren KJ, Craik DJ. Discovery, structure and biological activities of cyclotides. Advanced Drug Delivery Reviews. 61: 918-30. PMID 19470399 DOI: 10.1016/J.Addr.2009.05.003  0.44
2009 Trabi M, Mylne JS, Sando L, Craik DJ. Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides Organic and Biomolecular Chemistry. 7: 2378-2388. PMID 19462049 DOI: 10.1039/B823020J  0.356
2009 Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ. Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Journal of Biological Chemistry. 284: 20275-20284. PMID 19447885 DOI: 10.1074/Jbc.M109.015339  0.496
2009 Craik DJ. Circling the enemy: cyclic proteins in plant defence Trends in Plant Science. 14: 328-335. PMID 19423383 DOI: 10.1016/J.Tplants.2009.03.003  0.392
2009 Haugaard-Jönsson LM, Hossain MA, Daly NL, Bathgate RAD, Wade JD, Craik DJ, Rosengren KJ. Structural Properties of Relaxin Chimeras Annals of the New York Academy of Sciences. 1160: 27-30. PMID 19416154 DOI: 10.1111/J.1749-6632.2008.03805.X  0.414
2009 Rosengren KJ, Bathgate RAD, Craik DJ, Daly NL, Haugaard‐Jönsson LM, Hossain MA, Wade JD. Structural Insights into the Function of Relaxins Annals of the New York Academy of Sciences. 1160: 20-26. PMID 19416153 DOI: 10.1111/J.1749-6632.2009.03833.X  0.462
2009 Ireland DC, Colgrave ML, Daly NL, Craik DJ. The discovery and development of a natural combinatorial peptide template: the cyclotides. Advances in Experimental Medicine and Biology. 611: 477-478. PMID 19400272 DOI: 10.1007/978-0-387-73657-0_205  0.431
2009 Gruber CW, Cemazar M, Anderson MA, Craik DJ. Enzyme mechanism and function of a novel plant PDI involved in the oxidative folding of cystine knot defense peptides. Advances in Experimental Medicine and Biology. 611: 31-32. PMID 19400080 DOI: 10.1007/978-0-387-73657-0_13  0.389
2009 Wang CK, Hu SH, Martin JL, Sjögren T, Hajdu J, Bohlin L, Claeson P, Göransson U, Rosengren KJ, Tang J, Tan NH, Craik DJ. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. The Journal of Biological Chemistry. 284: 10672-83. PMID 19211551 DOI: 10.1074/Jbc.M900021200  0.737
2009 Haugaard-Jönsson LM, Hossain MA, Daly NL, Craik DJ, Wade JD, Rosengren KJ. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Biochemical Journal. 419: 619-627. PMID 19178384 DOI: 10.1042/Bj20082353  0.437
2009 Daly NL, Craik DJ. Structural studies of conotoxins. Iubmb Life. 61: 144-150. PMID 19165896 DOI: 10.1002/Iub.158  0.396
2009 Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/Jbc.M804950200  0.457
2009 Zhang J, Liao B, Craik DJ, Li JT, Hu M, Shu WS. Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity. Gene. 431: 23-32. PMID 19071200 DOI: 10.1016/J.Gene.2008.11.005  0.315
2009 Colgrave ML, Kotze AC, Kopp S, McCarthy JS, Coleman GT, Craik DJ. Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms. Acta Tropica. 109: 163-6. PMID 19059189 DOI: 10.1016/J.Actatropica.2008.11.003  0.332
2009 Gunasekera S, Daly NL, Clark RJ, Craik DJ. Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxidants & Redox Signaling. 11: 971-80. PMID 19025420 DOI: 10.1089/Ars.2008.2295  0.4
2009 Gruber CW, Čemažar M, Mechler A, Martin LL, Craik DJ. Biochemical and biophysical characterization of a novel plant protein disulfide isomerase Biopolymers. 92: 35-43. PMID 18985675 DOI: 10.1002/Bip.21113  0.335
2009 Hawkins B, Cross K, Craik D. Solution structure of the B-chain of insulin as determined by 1H NMR spectroscopy. Comparison with the crystal structure of the insulin hexamer and with the solution structure of the insulin monomer International Journal of Peptide and Protein Research. 46: 424-433. PMID 8567187 DOI: 10.1111/J.1399-3011.1995.Tb01077.X  0.358
2009 Rosengren KJ, Daly NL, Craik DJ. NMR of peptide toxins Annual Reports On Nmr Spectroscopy. 68: 89-147. DOI: 10.1016/S0066-4103(09)06802-1  0.481
2009 Halai R, Clark R, Nevin S, Adams D, Craik D. Mutational atudies on alpha-conotoxin VCL1 Biopolymers. 92: 315-315. DOI: 10.1002/Bip.21223  0.357
2008 Gunasekera S, Foley FM, Clark RJ, Sando L, Fabri LJ, Craik DJ, Daly NL. Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. Journal of Medicinal Chemistry. 51: 7697-704. PMID 19053834 DOI: 10.1021/Jm800704E  0.406
2008 Westermann J, Clark RJ, Craik DJ. Binding Mode of α-Conotoxins to an Acetylcholine Binding Protein Determined by Saturation Transfer Difference NMR Protein and Peptide Letters. 15: 910-914. PMID 18991766 DOI: 10.2174/092986608785849335  0.357
2008 Schirra HJ, Anderson MA, Craik DJ. Structural Refinement of Insecticidal Plant Proteinase Inhibitors from Nicotiana alata Protein and Peptide Letters. 15: 903-909. PMID 18991765 DOI: 10.2174/092986608785849326  0.336
2008 Callaghan B, Haythornthwaite A, Berecki G, Clark RJ, Craik DJ, Adams DJ. Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Journal of Neuroscience. 28: 10943-10951. PMID 18945902 DOI: 10.1523/Jneurosci.3594-08.2008  0.439
2008 Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/Jm800278K  0.429
2008 Westermann J, Craik DJ. NMR in peptide drug development. Methods of Molecular Biology. 494: 87-113. PMID 18726570 DOI: 10.1007/978-1-59745-419-3_6  0.405
2008 Saska I, Colgrave ML, Jones A, Anderson MA, Craik DJ. Quantitative analysis of backbone-cyclised peptides in plants. Journal of Chromatography B. 872: 107-114. PMID 18701356 DOI: 10.1016/J.Jchromb.2008.07.023  0.42
2008 Saska I, Craik DJ. Protease-catalysed protein splicing: a new post-translational modification? Trends in Biochemical Sciences. 33: 363-368. PMID 18599295 DOI: 10.1016/J.Tibs.2008.04.016  0.394
2008 Haugaard-Jönsson LM, Hossain MA, Daly NL, Bathgate RAD, Wade JD, Craik DJ, Rosengren KJ. Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist. Journal of Biological Chemistry. 283: 23811-23818. PMID 18577524 DOI: 10.1074/Jbc.M800489200  0.416
2008 Plan MRR, Saska I, Cagauan AG, Craik DJ. Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice Pest Pomacea canaliculata (Golden Apple Snail) Journal of Agricultural and Food Chemistry. 56: 5237-5241. PMID 18557620 DOI: 10.1021/Jf800302F  0.36
2008 Cemazar M, Joshi A, Daly NL, Mark AE, Craik DJ. The Structure of a Two-Disulfide Intermediate Assists in Elucidating the Oxidative Folding Pathway of a Cyclic Cystine Knot Protein Structure. 16: 842-851. PMID 18547517 DOI: 10.1016/J.Str.2008.02.023  0.407
2008 Imperial JS, Chen P, Sporning A, Terlau H, Daly NL, Craik DJ, Alewood PF, Olivera BM. Tyrosine-rich conopeptides affect voltage-gated K+ channels. The Journal of Biological Chemistry. 283: 23026-32. PMID 18505731 DOI: 10.1074/Jbc.M800084200  0.459
2008 Mylne JS, Craik DJ. 15N cyclotides by whole plant labeling Biopolymers. 90: 575-580. PMID 18464271 DOI: 10.1002/Bip.21012  0.448
2008 Colgrave ML, Kotze AC, Huang YH, O'Grady J, Simonsen SM, Craik DJ. Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry. 47: 5581-9. PMID 18426225 DOI: 10.1021/Bi800223Y  0.391
2008 Simonsen SM, Sando L, Rosengren KJ, Wang CK, Colgrave ML, Daly NL, Craik DJ. Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity Journal of Biological Chemistry. 283: 9805-9813. PMID 18258598 DOI: 10.1074/Jbc.M709303200  0.439
2008 Clark RJ, Daly NL, Halai R, Nevin ST, Adams DJ, Craik DJ. The three-dimensional structure of the analgesic α-conotoxin, RgIA Febs Letters. 582: 597-602. PMID 18242183 DOI: 10.1016/J.Febslet.2008.01.027  0.453
2008 Barbeta BL, Marshall AT, Gillon AD, Craik DJ, Anderson MA. Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae Proceedings of the National Academy of Sciences of the United States of America. 105: 1221-1225. PMID 18202177 DOI: 10.1073/Pnas.0710338104  0.401
2008 Herrmann A, Burman R, Mylne JS, Karlsson G, Gullbo J, Craik DJ, Clark RJ, Göransson U. The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry. 69: 939-52. PMID 18191970 DOI: 10.1016/J.Phytochem.2007.10.023  0.617
2008 Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G, Lewis RJ. Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. The Journal of Biological Chemistry. 283: 7100-8. PMID 18174156 DOI: 10.1074/Jbc.M706477200  0.35
2008 Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ. Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. Journal of Natural Products. 71: 47-52. PMID 18081258 DOI: 10.1021/Np070393G  0.573
2008 Kaas Q, Westermann J, Halai R, Wang CKL, Craik DJ. ConoServer, a database for conopeptide sequences and structures Bioinformatics. 24: 445-446. PMID 18065428 DOI: 10.1093/Bioinformatics/Btm596  0.392
2008 Leta Aboye T, Clark RJ, Craik DJ, Göransson U. Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. Chembiochem : a European Journal of Chemical Biology. 9: 103-13. PMID 18058973 DOI: 10.1002/Cbic.200700357  0.667
2008 Cemazar M, Craik DJ. Microwave-assisted Boc-solid phase peptide synthesis of cyclic cysteine-rich peptides. Journal of Peptide Science. 14: 683-689. PMID 18044816 DOI: 10.1002/Psc.972  0.44
2008 Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. Cyclotides as natural anti-HIV agents. Biopolymers. 90: 51-60. PMID 18008336 DOI: 10.1002/Bip.20886  0.304
2008 Čemažar M, Gruber CW, Craik DJ. Oxidative folding of cyclic cystine knot proteins Antioxidants and Redox Signaling. 10: 103-111. PMID 17961069 DOI: 10.1089/Ars.2007.1849  0.364
2008 Ekberg J, Craik DJ, Adams DJ. Conotoxin modulation of voltage-gated sodium channels. The International Journal of Biochemistry & Cell Biology. 40: 2363-8. PMID 17951097 DOI: 10.1016/J.Biocel.2007.08.017  0.45
2008 Najbar L, Craik D, Wade J, McLeish M. NMR spectroscopy of T4 Lysozyme peptide fragments Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr7156  0.394
2008 Preza G, Fernandes A, Clark RJ, Craik DJ, Ganz T, Nemeth E. Structural Aspects of Hepcidin-Ferroportin Binding Blood. 112: 119-119. DOI: 10.1182/Blood.V112.11.119.119  0.321
2008 Aboye TL, Clark RJ, Craik DJ, Goransson U. Synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. Planta Medica. 74: 1158-1158. DOI: 10.1055/S-0028-1084795  0.657
2008 Craik D, Saska I, Gruber C, Gillon A, Anderson M. Synthesis of cyclic peptide chitinase inhibitors: Natural products with chemotherapeutic potential Journal of Peptide Science. 14: 13-13. DOI: 10.1002/Psc.1089  0.402
2008 Aboye TL, Clark RJ, Craik DJ, Göransson U. Cover Picture: Ultra‐Stable Peptide Scaffolds for Protein Engineering—Synthesis and Folding of the Circular Cystine Knotted Cyclotide Cycloviolacin O2 (ChemBioChem 1/2008) Chembiochem. 9: 1-1. DOI: 10.1002/Cbic.200790068  0.635
2007 Gillon AD, Saska I, Jennings CV, Guarino RF, Craik DJ, Anderson MA. Biosynthesis of circular proteins in plants. Plant Journal. 53: 505-515. PMID 18086282 DOI: 10.1111/J.1365-313X.2007.03357.X  0.368
2007 Wang CKL, Kaas Q, Chiche L, Craik DJ. CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering Nucleic Acids Research. 36: 206-210. PMID 17986451 DOI: 10.1093/Nar/Gkm953  0.329
2007 Nevin ST, Clark RJ, Klimis H, Christie MJ, Craik DJ, Adams DJ. Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology. 72: 1406-10. PMID 17804600 DOI: 10.1124/Mol.107.040568  0.457
2007 Saska I, Gillon AD, Hatsugai N, Dietzgen RG, Hara-Nishimura I, Anderson MA, Craik DJ. An asparaginyl endopeptidase mediates in vivo protein backbone cyclization Journal of Biological Chemistry. 282: 29721-29728. PMID 17698845 DOI: 10.1074/Jbc.M705185200  0.433
2007 Greenwood KP, Daly NL, Brown DL, Stow JL, Craik DJ. The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. The International Journal of Biochemistry & Cell Biology. 39: 2252-64. PMID 17693122 DOI: 10.1016/J.Biocel.2007.06.016  0.404
2007 Daly NL, Chen Y, Rosengren KJ, Marx U, Phillips M, Waring A, Wang W, Lehrer R, Craik DJ. Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin. Biochemistry. 46: 9920-9928. PMID 17685559 DOI: 10.1021/Bi700720E  0.372
2007 Craik DJ, Adams DJ. Chemical modification of conotoxins to improve stability and activity Acs Chemical Biology. 2: 457-468. PMID 17649970 DOI: 10.1021/Cb700091J  0.545
2007 Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ. The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides. Chembiochem : a European Journal of Chemical Biology. 8: 1001-11. PMID 17534989 DOI: 10.1002/Cbic.200700097  0.665
2007 Gruber CW, Čemažar M, Clark RJ, Horibe T, Renda RF, Anderson MA, Craik DJ. A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins Journal of Biological Chemistry. 282: 20435-20446. PMID 17522051 DOI: 10.1074/Jbc.M700018200  0.344
2007 Craik DJ, Clark RJ, Daly NL. Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins Expert Opinion On Investigational Drugs. 16: 595-604. PMID 17461734 DOI: 10.1517/13543784.16.5.595  0.454
2007 Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. Bmc Structural Biology. 7: 28. PMID 17445276 DOI: 10.1186/1472-6807-7-28  0.422
2007 Craik DJ, Daly NL. NMR as a tool for elucidating the structures of circular and knotted proteins Molecular Biosystems. 3: 257-265. PMID 17372654 DOI: 10.1039/B616856F  0.361
2007 Gruber CW, Čemažar M, Anderson MA, Craik DJ. Insecticidal plant cyclotides and related cystine knot toxins Toxicon. 49: 561-575. PMID 17224167 DOI: 10.1016/J.Toxicon.2006.11.018  0.396
2007 Gruber GW, Cemazar M, Clark R, Horibe T, Renda R, Anderson MA, Craik DJ. Enzyme mechanism and function of a novel plant protein disulfide isomerase involved in the oxidative folding of cystine knot defence peptides Biopolymers. 88: 541-541. DOI: 10.1002/Bip.20783  0.4
2006 Lovelace ES, Armishaw CJ, Colgrave ML, Wahlstrom ME, Alewood PF, Daly NL, Craik DJ. Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. Journal of Medicinal Chemistry. 49: 6561-8. PMID 17064074 DOI: 10.1021/Jm060299H  0.467
2006 Gunasekera S, Daly NL, Anderson MA, Craik DJ. Chemical synthesis and biosynthesis of the cyclotide family of circular proteins. Iubmb Life. 58: 515-24. PMID 17002979 DOI: 10.1080/15216540600889532  0.414
2006 Mulvenna JP, Mylne JS, Bharathi R, Burton RA, Shirley NJ, Fincher GB, Anderson MA, Craik DJ. Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins? The Plant Cell. 18: 2134-44. PMID 16935986 DOI: 10.1105/Tpc.106.042812  0.347
2006 Ireland DC, Colgrave ML, Craik DJ. A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability Biochemical Journal. 400: 1-12. PMID 16872274 DOI: 10.1042/Bj20060627  0.434
2006 Rosengren KJ, Zhang S, Lin F, Daly NL, Scott DJ, Hughes RA, Bathgate RA, Craik DJ, Wade JD. Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. The Journal of Biological Chemistry. 281: 28287-95. PMID 16867980 DOI: 10.1074/Jbc.M603829200  0.429
2006 Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. The Journal of Biological Chemistry. 281: 28068-78. PMID 16857681 DOI: 10.1074/Jbc.M604992200  0.446
2006 Marx UC, Daly NL, Craik DJ. NMR of conotoxins: structural features and an analysis of chemical shifts of post‐translationally modified amino acids Magnetic Resonance in Chemistry. 44. PMID 16826542 DOI: 10.1002/Mrc.1821  0.356
2006 Imperial JS, Bansal PS, Alewood PF, Daly NL, Craik DJ, Sporning A, Terlau H, López-Vera E, Bandyopadhyay PK, Olivera BM. A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry. 45: 8331-40. PMID 16819832 DOI: 10.1021/Bi060263R  0.383
2006 Gruber CW, Čemažar M, Heras B, Martin JL, Craik DJ. Protein disulfide isomerase: the structure of oxidative folding Trends in Biochemical Sciences. 31: 455-464. PMID 16815710 DOI: 10.1016/J.Tibs.2006.06.001  0.319
2006 Daly NL, Chen Y, Foley FM, Bansal PS, Bharathi R, Clark RJ, Sommerhoff CP, Craik DJ. The Absolute Structural Requirement for a Proline in the P3′-position of Bowman-Birk Protease Inhibitors Is Surmounted in the Minimized SFTI-1 Scaffold Journal of Biological Chemistry. 281: 23668-23675. PMID 16766795 DOI: 10.1074/Jbc.M601426200  0.461
2006 Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ. The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Journal of Biological Chemistry. 281: 23254-23263. PMID 16754662 DOI: 10.1074/Jbc.M604550200  0.512
2006 Craik DJ, Cemazar M, Daly NL. The cyclotides and related macrocyclic peptides as scaffolds in drug design. Current Opinion in Drug Discovery & Development. 9: 251-60. PMID 16566295  0.314
2006 Cemazar M, Daly NL, Häggblad S, Lo KP, Yulyaningsih E, Craik DJ. Knots in rings : The circular knotted protein momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate Journal of Biological Chemistry. 281: 8224-8232. PMID 16547012 DOI: 10.1074/Jbc.M513399200  0.392
2006 Craik DJ. Seamless Proteins Tie Up Their Loose Ends Science. 311: 1563-1564. PMID 16543448 DOI: 10.1126/Science.1125248  0.319
2006 Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Journal of Biological Chemistry. 281: 14136-14143. PMID 16500898 DOI: 10.1074/Jbc.M512419200  0.521
2006 Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ. Discovery and Characterization of a Linear Cyclotide from Viola odorata: Implications for the Processing of Circular Proteins Journal of Molecular Biology. 357: 1522-1535. PMID 16488428 DOI: 10.1016/J.Jmb.2006.01.051  0.48
2006 Chen B, Colgrave ML, Wang C, Craik DJ. Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. Journal of Natural Products. 69: 23-8. PMID 16441062 DOI: 10.1021/Np050317I  0.441
2006 Craik DJ, Cemazar M, Wang CKL, Daly NL. The cyclotide family of circular miniproteins: Nature's combinatorial peptide template Biopolymers. 84: 250-266. PMID 16440288 DOI: 10.1002/Bip.20451  0.43
2006 Rosengren KJ, Lin F, Bathgate RAD, Tregear GW, Daly NL, Wade JD, Craik DJ. Solution Structure and Novel Insights into the Determinants of the Receptor Specificity of Human Relaxin-3 Journal of Biological Chemistry. 281: 5845-5851. PMID 16365033 DOI: 10.1074/Jbc.M511210200  0.372
2006 Clark RJ, Daly NL, Craik DJ. Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochemical Journal. 394: 85-93. PMID 16300479 DOI: 10.1042/Bj20051691  0.47
2006 Daly NL, Clark RJ, Plan MR, Craik DJ. Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif Biochemical Journal. 393: 619-626. PMID 16207177 DOI: 10.1042/Bj20051371  0.428
2006 Čemažar M, Craik DJ. Factors Influencing the Stability of Cyclotides: Proteins with a Circular Backbone and Cystine Knot Motif * International Journal of Peptide Research and Therapeutics. 12: 253-260. DOI: 10.1007/S10989-006-9019-2  0.35
2006 Lovelace ES, Armishaw CJ, Colgrave ML, Alewood PF, Daly NL, Craik DJ. Backbone cyclization improves the enzymatic stability of chi-conotoxin, MrIA, whilst maintaining its structure and NET-modulating activity Biopolymers. 80: 641-642. DOI: 10.1007/978-0-387-26575-9_283  0.318
2006 Craik DJ, Rosengren KJ, Sando L, Simonsen SS. Threaded rings and complex topologies in antimicrobial peptides: Nature's engineering templates Biopolymers. 9: 243-247. DOI: 10.1007/978-0-387-26575-9_101  0.486
2005 Bansal PS, Grieve PA, Marschke RJ, Daly NL, McGhie E, Craik DJ, Alewood PF. Chemical synthesis and structure elucidation of bovine kappa-casein (1-44). Biochemical and Biophysical Research Communications. 340: 1098-103. PMID 16403439 DOI: 10.1016/J.Bbrc.2005.12.115  0.393
2005 Colgrave ML, Jones A, Craik DJ. Peptide quantification by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry: investigations of the cyclotide kalata B1 in biological fluids. Journal of Chromatography A. 1091: 187-193. PMID 16395810 DOI: 10.1016/J.Chroma.2005.07.094  0.31
2005 Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Göransson U, Craik DJ. A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). The Plant Cell. 17: 3176-89. PMID 16199617 DOI: 10.1105/Tpc.105.034678  0.626
2005 Clark RJ, Fischer H, Dempster L, Daly NL, Rosengren KJ, Nevin ST, Meunier FA, Adams DJ, Craik DJ. Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII Proceedings of the National Academy of Sciences of the United States of America. 102: 13767-13772. PMID 16162671 DOI: 10.1073/Pnas.0504613102  0.568
2005 Mulvenna J, Foley FM, Craik DJ. Discovery, structural determination, and putative processing of the precursor protein that produces the cyclic trypsin inhibitor sunflower trypsin inhibitor 1 Journal of Biological Chemistry. 280: 32245-32253. PMID 16036912 DOI: 10.1074/Jbc.M506060200  0.373
2005 Schirra HJ, Craik DJ. Structure and folding of potato type II proteinase inhibitors: circular permutation and intramolecular domain swapping. Protein and Peptide Letters. 12: 421-431. PMID 16029154 DOI: 10.2174/0929866054395266  0.304
2005 Alewood D, Nielsen K, Alewood PF, Craik DJ, Andrews P, Nerrie M, White S, Domagala T, Walker F, Rothacker J, Burgess AW, Nice EC. The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF). Growth Factors (Chur, Switzerland). 23: 97-110. PMID 16019431 DOI: 10.1080/08977190500096061  0.412
2005 Tregear GW, Bathgate RA, Layfield S, Ferraro T, Gundlach A, Ma S, Lin F, Hanson NF, Summers RJ, Rosengren J, Craik DJ, Wade JD. The chemistry and biology of human relaxin-3. Annals of the New York Academy of Sciences. 1041: 40-6. PMID 15956686 DOI: 10.1196/Annals.1282.008  0.385
2005 Nilsson KP, Lovelace ES, Caesar CE, TynngÃ¥rd N, Alewood PF, Johansson HM, Sharpe IA, Lewis RJ, Daly NL, Craik DJ. Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers. 80: 815-23. PMID 15931669 DOI: 10.1002/Bip.20302  0.39
2005 Mulvenna JP, Sando L, Craik DJ. Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A Structure. 13: 691-701. PMID 15893660 DOI: 10.1016/J.Str.2005.02.013  0.356
2005 Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ. Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide. The Journal of Biological Chemistry. 280: 22395-405. PMID 15824119 DOI: 10.1074/Jbc.M501737200  0.374
2005 Craik DJ, Daly NL. Oxidative folding of the cystine knot motif in cyclotide proteins. Protein and Peptide Letters. 12: 147-152. PMID 15723640 DOI: 10.2174/0929866053005863  0.343
2005 Korsinczky MLJ, Clark RJ, Craik DJ. Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1 Biochemistry. 44: 1145-1153. PMID 15667208 DOI: 10.1021/Bi048297R  0.412
2005 Jennings CV, Rosengren KJ, Daly NL, Plan M, Stevens J, Scanlon MJ, Waine C, Norman DG, Anderson MA, Craik DJ. Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? Biochemistry. 44: 851-60. PMID 15654741 DOI: 10.1021/Bi047837H  0.448
2005 Kamimori H, Hall KN, Craik DJ, Aguilar M. Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance. Analytical Biochemistry. 337: 149-153. PMID 15649388 DOI: 10.1016/J.Ab.2004.10.028  0.334
2005 Craik DJ. European Peptide Society--28th Symposium and Third International Peptide Symposium. Peptides--bridges between disciplines. 5-10 September 2004, Prague, Czech Republic. Idrugs : the Investigational Drugs Journal. 7: 992-3. PMID 15551170  0.301
2005 Craik DJ, Daly NL, Mulvenna J, Plan MR, Trabi M. Discovery, structure and biological activities of the cyclotides. Current Protein & Peptide Science. 5: 297-315. PMID 15544527 DOI: 10.2174/1389203043379512  0.336
2005 Koltay A, Daly NL, Gustafson KR, Craik DJ. Structure of Circulin B and Implications for Antimicrobial Activity of the Cyclotides International Journal of Peptide Research and Therapeutics. 11: 99-106. DOI: 10.1007/S10989-004-1722-2  0.421
2004 Simonsen SM, Daly NL, Craik DJ. Capped acyclic permutants of the circular protein kalata B1 Febs Letters. 577: 399-402. PMID 15556617 DOI: 10.1016/J.Febslet.2004.10.034  0.385
2004 Korsinczky MLJ, Schirra HJ, Craik DJ. Sunflower trypsin inhibitor-1. Current Protein & Peptide Science. 5: 351-364. PMID 15544530 DOI: 10.2174/1389203043379594  0.447
2004 Rosengren KJ, Göransson U, Otvos L, Craik DJ. Cyclization of pyrrhocoricin retains structural elements crucial for the antimicrobial activity of the native peptide. Biopolymers. 76: 446-58. PMID 15478127 DOI: 10.1002/Bip.20159  0.666
2004 Daly NL, Gustafson KR, Craik DJ. The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. Febs Letters. 574: 69-72. PMID 15358541 DOI: 10.1016/J.Febslet.2004.08.007  0.324
2004 Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ. Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. The Journal of Biological Chemistry. 279: 46858-67. PMID 15328347 DOI: 10.1074/Jbc.M407421200  0.407
2004 Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. The Journal of Biological Chemistry. 279: 44188-96. PMID 15297466 DOI: 10.1074/Jbc.M406154200  0.331
2004 Trabi M, Craik DJ. Tissue-Specific Expression of Head-to-Tail Cyclized Miniproteins in Violaceae and Structure Determination of the Root Cyclotide Viola hederacea root cyclotide1 The Plant Cell. 16: 2204-2216. PMID 15295104 DOI: 10.1105/Tpc.104.021790  0.46
2004 Millard EL, Daly NL, Craik DJ. Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors. European Journal of Biochemistry. 271: 2320-6. PMID 15182347 DOI: 10.1111/J.1432-1033.2004.04148.X  0.338
2004 Trabi M, Svangård E, Herrmann A, Göransson U, Claeson P, Craik DJ, Bohlin L. Variations in cyclotide expression in viola species. Journal of Natural Products. 67: 806-10. PMID 15165141 DOI: 10.1021/Np034068E  0.726
2004 Abuja PM, Zenz A, Trabi M, Craik DJ, Lohner K. The cyclic antimicrobial peptide RTD-1 induces stabilized lipid–peptide domains more efficiently than its open-chain analogue Febs Letters. 566: 301-306. PMID 15147913 DOI: 10.1016/J.Febslet.2004.03.112  0.417
2004 Colgrave ML, Craik DJ. Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot. Biochemistry. 43: 5965-5975. PMID 15147180 DOI: 10.1021/Bi049711Q  0.345
2004 Rosengren KJ, Blond A, Afonso C, Tabet JC, Rebuffat S, Craik DJ. Structure of thermolysin cleaved microcin J25: extreme stability of a two-chain antimicrobial peptide devoid of covalent links. Biochemistry. 43: 4696-702. PMID 15096038 DOI: 10.1021/Bi0361261  0.454
2004 Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. The Journal of Biological Chemistry. 279: 25774-82. PMID 15044438 DOI: 10.1074/Jbc.M313002200  0.48
2004 Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ. Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework. Structure (London, England : 1993). 12: 85-94. PMID 14725768 DOI: 10.1016/J.Str.2003.11.019  0.415
2004 Craik DJ. Preface [Hot Topic: Circular Peptides and Proteins (Guest Editor: David J. Craik)] Current Protein & Peptide Science. 5. DOI: 10.2174/1389203043379648  0.423
2004 Rosengren J, Jen F, Clark R, Daly N, Göransson U, Jones A, Craik D. A novel threaded ring structure for the antimicrobial peptide microcin J25 Journal of Peptide Science. 10: 116-116. DOI: 10.1002/Psc.617  0.663
2003 Jones CE, Daly NL, Cobine PA, Craik DJ, Dameron CT. Structure and metal binding studies of the second copper binding domain of the Menkes ATPase. Journal of Structural Biology. 143: 209-18. PMID 14572476 DOI: 10.1016/J.Jsb.2003.08.008  0.311
2003 Rosengren KJ, Clark RJ, Daly NL, Göransson U, Jones A, Craik DJ. Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society. 125: 12464-74. PMID 14531690 DOI: 10.1021/Ja0367703  0.677
2003 Göransson U, Craik DJ. Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. The Journal of Biological Chemistry. 278: 48188-96. PMID 12960160 DOI: 10.1074/Jbc.M308771200  0.613
2003 Meutermans WD, Bourne GT, Golding SW, Horton DA, Campitelli MR, Craik D, Scanlon M, Smythe ML. Difficult macrocyclizations: new strategies for synthesizing highly strained cyclic tetrapeptides. Organic Letters. 5: 2711-4. PMID 12868896 DOI: 10.1021/Ol034907O  0.306
2003 Janssen BJ, Schirra HJ, Lay FT, Anderson MA, Craik DJ. Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds. Biochemistry. 42: 8214-22. PMID 12846570 DOI: 10.1021/Bi034379O  0.37
2003 Craik DJ, Daly NL, Saska I, Trabi M, Rosengren KJ. Structures of Naturally Occurring Circular Proteins from Bacteria Journal of Bacteriology. 185: 4011-4021. PMID 12837774 DOI: 10.1128/Jb.185.14.4011-4021.2003  0.3
2003 Barry DG, Daly NL, Clark RJ, Sando L, Craik DJ. Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity Biochemistry. 42: 6688-6695. PMID 12779323 DOI: 10.1021/Bi027323N  0.34
2003 Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/Jm020426J  0.577
2003 Marx UC, Korsinczky MLJ, Schirra HJ, Jones A, Condie B, Otvos L, Craik DJ. Enzymatic Cyclization of a Potent Bowman-Birk Protease Inhibitor, Sunflower Trypsin Inhibitor-1, and Solution Structure of an Acyclic Precursor Peptide Journal of Biological Chemistry. 278: 21782-21789. PMID 12621047 DOI: 10.1074/Jbc.M212996200  0.424
2003 Rosengren KJ, Daly NL, Plan MR, Waine C, Craik DJ. Twists, Knots, and Rings in Proteins STRUCTURAL DEFINITION OF THE CYCLOTIDE FRAMEWORK Journal of Biological Chemistry. 278: 8606-8616. PMID 12482868 DOI: 10.1074/Jbc.M211147200  0.381
2003 Daly NL, Clark RJ, Craik DJ. Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides Journal of Biological Chemistry. 278: 6314-6322. PMID 12482862 DOI: 10.1074/Jbc.M210492200  0.399
2003 Lay FT, Schirra HJ, Scanlon MJ, Anderson MA, Craik DJ. The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP. Journal of Molecular Biology. 325: 175-88. PMID 12473460 DOI: 10.1016/S0022-2836(02)01103-8  0.386
2003 Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/Jbc.M210280200  0.399
2003 Craik DJ, Barry DG, Clark RJ, Daly NL, Sando L. Structure‐Function Studies of the Plant Cyclotides: The Role of a Circular Protein Backbone Journal of Toxicology-Toxin Reviews. 22: 555-576. DOI: 10.1081/Txr-120026914  0.377
2003 daly NL, clark RJ, Göransson U, craik DJ. Diversity in the disulfide folding pathways of cystine knot peptides Letters in Peptide Science. 10: 523-531. DOI: 10.1007/Bf02442584  0.674
2003 Craik DJ, Clark RJ. NMR and Drug Discovery Burger's Medicinal Chemistry and Drug Discovery. 507-582. DOI: 10.1002/0471266949.Bmc011  0.309
2002 Wilce JA, Daly NL, Craik DJ. Synthesis and structural analysis of the N-terminal domain of the thyroid-hormone binding protein transthyretin Clinical Chemistry and Laboratory Medicine. 40: 1221-1228. PMID 12553422 DOI: 10.1515/Cclm.2002.212  0.383
2002 Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ. A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity. The Journal of Biological Chemistry. 277: 48849-57. PMID 12376538 DOI: 10.1074/Jbc.M208842200  0.561
2002 Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/Jbc.M201611200  0.475
2002 Craik DJ, Simonsen S, Daly NL. The cyclotides: novel macrocyclic peptides as scaffolds in drug design. Current Opinion in Drug Discovery & Development. 5: 251-60. PMID 11926131  0.322
2002 Trabi M, Craik DJ. Circular proteins — no end in sight Trends in Biochemical Sciences. 27: 132-138. PMID 11893510 DOI: 10.1016/S0968-0004(02)02057-1  0.317
2002 Rosengren KJ, Wilson D, Daly NL, Alewood PF, Craik DJ. Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds. Biochemistry. 41: 3294-301. PMID 11876637 DOI: 10.1021/Bi011932Y  0.411
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