| Year |
Citation |
Score |
| 2020 |
Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C. Modulation of the ligand-gated ion channel (ELIC) and the 5-HT receptor via a common vestibule site. Elife. 9. PMID 31990273 DOI: 10.7554/Elife.51511 |
0.356 |
|
| 2019 |
Lummis SC, Tang B. Aromatic Residues in the Glycine Receptor Transmembrane form a Network Required for Function Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2121 |
0.384 |
|
| 2018 |
Lummis SC, Mosesso R, Dougherty DA. The Pros of nACh and 5-HT3 Receptors Biophysical Journal. 114: 299a-300a. DOI: 10.1016/J.Bpj.2017.11.1708 |
0.496 |
|
| 2017 |
Alqazzaz MA, Price KL, Lummis SC. The Proton Responsiveness in the Extracellular Domain of GLIC Differs in the Presence of the ELIC Transmembrane Domain. Biochemistry. PMID 28383883 DOI: 10.1021/Acs.Biochem.6B00900 |
0.365 |
|
| 2017 |
Price KL, Hirayama Y, Lummis SC. Subtle Differences among 5-HT3AC, 5-HT3AD, and 5-HT3AE Receptors Are Revealed by Partial Agonists. Acs Chemical Neuroscience. PMID 28367632 DOI: 10.1021/acschemneuro.6b00416 |
0.42 |
|
| 2016 |
Alqazzaz MA, Price KL, Lummis SC. Crotonic Acid Blocks the Gloeobacter Ligand-Gated Ion Channel (GLIC) via the Extracellular Domain. Biochemistry. PMID 27739668 DOI: 10.1021/Acs.Biochem.6B00531 |
0.46 |
|
| 2016 |
Price KL, Lillestol RK, Ulens C, Lummis SC. Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure. Acs Chemical Neuroscience. PMID 27656911 DOI: 10.1021/Acschemneuro.6B00132 |
0.477 |
|
| 2016 |
Tender GS, Dougherty DA, Lummis SC. Probing Molecular Interactions in Erwinia Ligand-Gated Ion Channel (ELIC) Biophysical Journal. 110: 457a. DOI: 10.1016/J.Bpj.2015.11.2449 |
0.366 |
|
| 2016 |
Rienzo M, Rocchi AR, Threatt SD, Dougherty DA, Lummis SC. Insights into Gating Motions of GLIC via Perturbation of Critical Prolines with Non-Canonical Amino Acid Probes Biophysical Journal. 110: 456a. DOI: 10.1016/J.Bpj.2015.11.2443 |
0.306 |
|
| 2015 |
Rienzo M, Rocchi AR, Threatt SD, Dougherty DA, Lummis SC. Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-Gated Ion Channel (GLIC) Supports Conserved Gating Motions Among Cys-Loop Receptors. The Journal of Biological Chemistry. PMID 26668320 DOI: 10.1074/Jbc.M115.694372 |
0.347 |
|
| 2015 |
Corradi J, Thompson AJ, McGonigle I, Price KL, Bouzat C, Lummis SC. 5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems. Acs Chemical Neuroscience. 6: 1158-64. PMID 25951416 DOI: 10.1021/acschemneuro.5b00080 |
0.38 |
|
| 2015 |
Alqazzaz MA, Lummis SC. Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features. Molecular Membrane Biology. 1-6. PMID 25865129 DOI: 10.3109/09687688.2015.1023377 |
0.371 |
|
| 2015 |
Price KL, Lillestol RK, Ulens C, Lummis SC. Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP. Acs Chemical Neuroscience. 6: 1151-7. PMID 25648658 DOI: 10.1021/cn500369h |
0.362 |
|
| 2015 |
Schaefer N, Kluck CJ, Price KL, Meiselbach H, Vornberger N, Schwarzinger S, Hartmann S, Langlhofer G, Schulz S, Schlegel N, Brockmann K, Lynch B, Becker CM, Lummis SC, Villmann C. Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 422-37. PMID 25568133 DOI: 10.1523/Jneurosci.1509-14.2015 |
0.328 |
|
| 2015 |
Lummis SC, Alqazzaz M. Glic-Elic Chimeras have Unexpected Characteristics Biophysical Journal. 108: 431a-432a. DOI: 10.1016/J.Bpj.2014.11.2358 |
0.363 |
|
| 2014 |
Price KL, Lummis SC. An atypical residue in the pore of Varroa destructor GABA-activated RDL receptors affects picrotoxin block and thymol modulation. Insect Biochemistry and Molecular Biology. 55: 19-25. PMID 25460510 DOI: 10.1016/j.ibmb.2014.10.002 |
0.46 |
|
| 2014 |
Thompson AJ, Alqazzaz M, Price KL, Weston DA, Lummis SC. Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. Biochemistry. 53: 6183-8. PMID 25238029 DOI: 10.1021/Bi5008035 |
0.44 |
|
| 2014 |
Thompson AJ, Verheij MH, Verbeek J, Windhorst AD, de Esch IJ, Lummis SC. The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors. Neuropharmacology. 86: 378-88. PMID 25174552 DOI: 10.1016/j.neuropharm.2014.08.008 |
0.429 |
|
| 2014 |
Comitani F, Cohen N, Ashby J, Botten D, Lummis SC, Molteni C. Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models. Journal of Computer-Aided Molecular Design. 28: 35-48. PMID 24442887 DOI: 10.1007/S10822-013-9704-0 |
0.45 |
|
| 2014 |
Kessler A, Sahin-Nadeem H, Lummis SC, Weigel I, Pischetsrieder M, Buettner A, Villmann C. GABA(A) receptor modulation by terpenoids from Sideritis extracts. Molecular Nutrition & Food Research. 58: 851-62. PMID 24273211 DOI: 10.1002/Mnfr.201300420 |
0.353 |
|
| 2014 |
Rienzo M, Shafaat OS, Gray HB, Lummis SC, Dougherty DA. Prokaryotic Cys-Loop Receptor Homologs as Mechanistic Models for Channel Function Biophysical Journal. 106: 545a. DOI: 10.1016/J.Bpj.2013.11.3037 |
0.339 |
|
| 2013 |
Del Cadia M, De Rienzo F, Weston DA, Thompson AJ, Menziani MC, Lummis SC. Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorganic & Medicinal Chemistry. 21: 7523-8. PMID 24128813 DOI: 10.1016/j.bmc.2013.09.028 |
0.421 |
|
| 2013 |
Thompson AJ, Lummis SC. A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors. British Journal of Pharmacology. 170: 391-402. PMID 23822584 DOI: 10.1111/bph.12287 |
0.398 |
|
| 2013 |
Lummis SC, Thompson AJ. Agonists and antagonists induce different palonosetron dissociation rates in 5-HT₃A and 5-HT₃AB receptors. Neuropharmacology. 73: 241-6. PMID 23747573 DOI: 10.1016/j.neuropharm.2013.05.010 |
0.434 |
|
| 2013 |
Thompson AJ, Verheij MH, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands. Chemmedchem. 8: 946-55. PMID 23640722 DOI: 10.1002/cmdc.201300032 |
0.413 |
|
| 2013 |
Thompson AJ, Lummis SC. Discriminating between 5-HT₃A and 5-HT₃AB receptors. British Journal of Pharmacology. 169: 736-47. PMID 23489111 DOI: 10.1111/bph.12166 |
0.459 |
|
| 2013 |
Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C. Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). The Journal of Biological Chemistry. 288: 8355-64. PMID 23364792 DOI: 10.1074/Jbc.M112.424507 |
0.341 |
|
| 2013 |
Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson UH, Lummis SC, Smit AB, Ulens C. Structural basis of ligand recognition in 5-HT3 receptors. Embo Reports. 14: 49-56. PMID 23196367 DOI: 10.1038/embor.2012.189 |
0.341 |
|
| 2012 |
Ashby JA, McGonigle IV, Price KL, Cohen N, Comitani F, Dougherty DA, Molteni C, Lummis SC. GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study. Biophysical Journal. 103: 2071-81. PMID 23200041 DOI: 10.1016/J.Bpj.2012.10.016 |
0.456 |
|
| 2012 |
Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, et al. Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 109: E3028-34. PMID 23035248 DOI: 10.1073/Pnas.1208208109 |
0.419 |
|
| 2012 |
Akdemir A, Edink E, Thompson AJ, Lummis SC, Kooistra AJ, de Graaf C, de Esch IJ. Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. Bioorganic & Medicinal Chemistry. 20: 5992-6002. PMID 22959526 DOI: 10.1016/j.bmc.2012.06.054 |
0.315 |
|
| 2012 |
Huang SH, Lewis TM, Lummis SC, Thompson AJ, Chebib M, Johnston GA, Duke RK. Mixed antagonistic effects of the ginkgolides at recombinant human Ï1 GABAC receptors. Neuropharmacology. 63: 1127-39. PMID 22828636 DOI: 10.1016/J.Neuropharm.2012.06.067 |
0.471 |
|
| 2012 |
Thompson AJ, Alqazzaz M, Ulens C, Lummis SC. The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor. Neuropharmacology. 63: 761-7. PMID 22677470 DOI: 10.1016/j.neuropharm.2012.05.027 |
0.482 |
|
| 2012 |
Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SC, Tsetlin VI. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 27079-86. PMID 22613724 DOI: 10.1074/Jbc.M112.363051 |
0.344 |
|
| 2012 |
Lummis SC, Harrison NJ, Wang J, Ashby JA, Millen KS, Beene DL, Dougherty DA. Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket. Acs Chemical Neuroscience. 3: 186-192. PMID 22448304 DOI: 10.1021/Cn200103N |
0.458 |
|
| 2012 |
Thompson AJ, Verheij MH, de Esch IJ, Lummis SC. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. The Journal of Pharmacology and Experimental Therapeutics. 341: 350-9. PMID 22306960 DOI: 10.1124/jpet.111.190769 |
0.453 |
|
| 2012 |
Thompson AJ, McGonigle I, Duke R, Johnston GA, Lummis SC. A single amino acid determines the toxicity of Ginkgo biloba extracts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1884-91. PMID 22253475 DOI: 10.1096/Fj.11-192765 |
0.427 |
|
| 2012 |
Limapichat W, AlQazzaz M, Richards C, Lummis S, Dougherty D, Lester H. Alpha6∗ Nicotinic Receptors and P2X Receptors: Physical and Functional Interactions Biophysical Journal. 102: 113a. DOI: 10.1016/J.Bpj.2011.11.635 |
0.483 |
|
| 2012 |
Kesters D, Brams M, Spurny R, Elk Rv, Thompson A, Geitmann M, Guskov A, Danielson H, Lummis S, Smit A, Ulens C. Structural Principles of Serotonin and Granisetron Recognition in a 5-HT3 / Binding Protein Chimera Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.629 |
0.468 |
|
| 2011 |
Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC. Cys-loop receptor channel blockers also block GLIC. Biophysical Journal. 101: 2912-8. PMID 22208189 DOI: 10.1016/j.bpj.2011.10.055 |
0.378 |
|
| 2011 |
Lummis SC, McGonigle I, Ashby JA, Dougherty DA. Two amino acid residues contribute to a cation-Ï€ binding interaction in the binding site of an insect GABA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12371-6. PMID 21865479 DOI: 10.1523/Jneurosci.1610-11.2011 |
0.481 |
|
| 2011 |
Lummis SC, Thompson AJ, Bencherif M, Lester HA. Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor. The Journal of Pharmacology and Experimental Therapeutics. 339: 125-31. PMID 21775477 DOI: 10.1124/jpet.111.185306 |
0.345 |
|
| 2011 |
Thompson AJ, Price KL, Lummis SC. Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors. The Journal of Physiology. 589: 4243-57. PMID 21708905 DOI: 10.1113/jphysiol.2011.208439 |
0.459 |
|
| 2011 |
Thompson AJ, Duke RK, Lummis SC. Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Molecular Pharmacology. 80: 183-90. PMID 21505038 DOI: 10.1124/mol.111.071415 |
0.362 |
|
| 2011 |
Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, et al. Anaesthetic impairment of immune function is mediated via GABA(A) receptors. Plos One. 6: e17152. PMID 21390329 DOI: 10.1371/Journal.Pone.0017152 |
0.457 |
|
| 2011 |
Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC. A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Molecular Pharmacology. 79: 742-8. PMID 21266487 DOI: 10.1124/Mol.110.069583 |
0.392 |
|
| 2011 |
Thompson AJ, Jarvis GE, Duke RK, Johnston GA, Lummis SC. Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 60: 488-95. PMID 21059362 DOI: 10.1016/J.Neuropharm.2010.11.003 |
0.357 |
|
| 2010 |
Quek GX, Lin D, Halliday JI, Absalom N, Ambrus JI, Thompson AJ, Lochner M, Lummis SC, McLeod MD, Chebib M. Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. Acs Chemical Neuroscience. 1: 796-809. PMID 22778816 DOI: 10.1021/cn100073x |
0.339 |
|
| 2010 |
Thompson AJ, Lester HA, Lummis SC. The structural basis of function in Cys-loop receptors. Quarterly Reviews of Biophysics. 43: 449-99. PMID 20849671 DOI: 10.1017/S0033583510000168 |
0.424 |
|
| 2010 |
Lochner M, Lummis SC. Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor. Biophysical Journal. 98: 1494-502. PMID 20409468 DOI: 10.1016/j.bpj.2009.12.4313 |
0.478 |
|
| 2010 |
McGonigle I, Lummis SC. Molecular characterization of agonists that bind to an insect GABA receptor. Biochemistry. 49: 2897-902. PMID 20180551 DOI: 10.1021/bi901698c |
0.533 |
|
| 2010 |
Vernekar SK, Hallaq HY, Clarkson G, Thompson AJ, Silvestri L, Lummis SC, Lochner M. Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. Journal of Medicinal Chemistry. 53: 2324-8. PMID 20146481 DOI: 10.1021/jm901827x |
0.309 |
|
| 2009 |
McGonigle I, Lummis SC. RDL receptors. Biochemical Society Transactions. 37: 1404-6. PMID 19909285 DOI: 10.1042/BST0371404 |
0.513 |
|
| 2009 |
Lummis SC. Locating GABA in GABA receptor binding sites. Biochemical Society Transactions. 37: 1343-6. PMID 19909273 DOI: 10.1042/BST0371343 |
0.451 |
|
| 2009 |
Bartos M, Price KL, Lummis SC, Bouzat C. Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. The Journal of Biological Chemistry. 284: 21478-87. PMID 19506073 DOI: 10.1074/jbc.M109.013797 |
0.323 |
|
| 2009 |
Barnes NM, Hales TG, Lummis SC, Peters JA. The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology. 56: 273-84. PMID 18761359 DOI: 10.1016/J.Neuropharm.2008.08.003 |
0.348 |
|
| 2008 |
Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA. A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10937-42. PMID 18945901 DOI: 10.1523/Jneurosci.2540-08.2008 |
0.45 |
|
| 2008 |
Thompson AJ, Lochner M, Lummis SC. Loop B is a major structural component of the 5-HT3 receptor. Biophysical Journal. 95: 5728-36. PMID 18931259 DOI: 10.1529/biophysj.108.135624 |
0.349 |
|
| 2008 |
Melis C, Lummis SC, Molteni C. Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104. Biophysical Journal. 95: 4115-23. PMID 18641081 DOI: 10.1529/Biophysj.107.127589 |
0.463 |
|
| 2008 |
Price KL, Bower KS, Thompson AJ, Lester HA, Dougherty DA, Lummis SC. A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry. 47: 6370-7. PMID 18498149 DOI: 10.1021/Bi800222N |
0.4 |
|
| 2008 |
Thompson AJ, Lummis SC. Antimalarial drugs inhibit human 5-HT(3) and GABA(A) but not GABA(C) receptors. British Journal of Pharmacology. 153: 1686-96. PMID 18311193 DOI: 10.1038/bjp.2008.34 |
0.374 |
|
| 2008 |
Bower KS, Price KL, Sturdee LE, Dayrell M, Dougherty DA, Lummis SC. 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. European Journal of Pharmacology. 580: 291-7. PMID 18082160 DOI: 10.1016/J.Ejphar.2007.11.014 |
0.412 |
|
| 2008 |
Padgett CL, Lummis SC. The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation. The Journal of Biological Chemistry. 283: 2702-8. PMID 17974564 DOI: 10.1074/jbc.M705699200 |
0.464 |
|
| 2007 |
Price KL, Millen KS, Lummis SC. Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors. The Journal of Biological Chemistry. 282: 25623-30. PMID 17606617 DOI: 10.1074/jbc.M702524200 |
0.414 |
|
| 2007 |
Thompson AJ, Lochner M, Lummis SC. The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors. British Journal of Pharmacology. 151: 666-77. PMID 17502851 DOI: 10.1038/sj.bjp.0707238 |
0.317 |
|
| 2007 |
Thompson AJ, Lummis SC. The 5-HT3 receptor as a therapeutic target. Expert Opinion On Therapeutic Targets. 11: 527-40. PMID 17373882 DOI: 10.1517/14728222.11.4.527 |
0.369 |
|
| 2007 |
Padgett CL, Hanek AP, Lester HA, Dougherty DA, Lummis SC. Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 886-92. PMID 17251430 DOI: 10.1523/Jneurosci.4791-06.2007 |
0.474 |
|
| 2006 |
Thompson AJ, Sullivan NL, Lummis SC. Characterization of 5-HT3 receptor mutations identified in schizophrenic patients. Journal of Molecular Neuroscience : Mn. 30: 273-81. PMID 17401153 DOI: 10.1385/JMN:30:3:273 |
0.352 |
|
| 2006 |
Thompson AJ, Lummis SC. 5-HT3 receptors. Current Pharmaceutical Design. 12: 3615-30. PMID 17073663 |
0.391 |
|
| 2006 |
Sullivan NL, Thompson AJ, Price KL, Lummis SC. Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Molecular Membrane Biology. 23: 442-51. PMID 17060161 DOI: 10.1080/09687860600831539 |
0.439 |
|
| 2006 |
Harrison NJ, Lummis SC. Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket. The Journal of Biological Chemistry. 281: 24455-61. PMID 16754677 DOI: 10.1074/jbc.M601775200 |
0.48 |
|
| 2006 |
Thompson AJ, Padgett CL, Lummis SC. Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop. The Journal of Biological Chemistry. 281: 16576-82. PMID 16595668 DOI: 10.1074/jbc.M601265200 |
0.344 |
|
| 2006 |
Reeves DC, Lummis SC. Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. Bmc Neuroscience. 7: 27. PMID 16571125 DOI: 10.1186/1471-2202-7-27 |
0.39 |
|
| 2006 |
Thompson AJ, Chau PL, Chan SL, Lummis SC. Unbinding pathways of an agonist and an antagonist from the 5-HT3 receptor. Biophysical Journal. 90: 1979-91. PMID 16387779 DOI: 10.1529/biophysj.105.069385 |
0.382 |
|
| 2006 |
Harrison NJ, Lummis SC. Molecular modeling of the GABA(C) receptor ligand-binding domain. Journal of Molecular Modeling. 12: 317-24. PMID 16249935 DOI: 10.1007/s00894-005-0034-6 |
0.455 |
|
| 2005 |
Lummis SC, L Beene D, Harrison NJ, Lester HA, Dougherty DA. A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor. Chemistry & Biology. 12: 993-7. PMID 16183023 DOI: 10.1016/J.Chembiol.2005.06.012 |
0.519 |
|
| 2005 |
Thompson AJ, Price KL, Reeves DC, Chan SL, Chau PL, Lummis SC. Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding. The Journal of Biological Chemistry. 280: 20476-82. PMID 15781467 DOI: 10.1074/Jbc.M413610200 |
0.368 |
|
| 2004 |
Beene DL, Price KL, Lester HA, Dougherty DA, Lummis SC. Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9097-104. PMID 15483128 DOI: 10.1523/Jneurosci.2429-04.2004 |
0.409 |
|
| 2004 |
Price KL, Lummis SC. The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor. The Journal of Biological Chemistry. 279: 23294-301. PMID 14998995 DOI: 10.1074/jbc.M314075200 |
0.399 |
|
| 2003 |
Reeves DC, Sayed MF, Chau PL, Price KL, Lummis SC. Prediction of 5-HT3 receptor agonist-binding residues using homology modeling. Biophysical Journal. 84: 2338-44. PMID 12668442 DOI: 10.1016/S0006-3495(03)75039-5 |
0.327 |
|
| 2002 |
Spier AD, Lummis SC. Immunological characterization of 5-HT3 receptor transmembrane topology. Journal of Molecular Neuroscience : Mn. 18: 169-78. PMID 12059035 DOI: 10.1385/JMN:18:3:169 |
0.406 |
|
| 2002 |
Reeves DC, Lummis SC. The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review). Molecular Membrane Biology. 19: 11-26. PMID 11989819 DOI: 10.1080/09687680110110048 |
0.426 |
|
| 2002 |
Greenfield LJ, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL. Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology. 42: 502-21. PMID 11955521 DOI: 10.1016/S0028-3908(01)00196-4 |
0.374 |
|
| 2002 |
Lummis SC, Fletcher EJ, Green T. Identification of a new site in the S1 ligand binding region of the NMDA receptor NR2A subunit involved in receptor activation by glutamate. Neuropharmacology. 42: 437-43. PMID 11955515 |
0.365 |
|
| 2001 |
Reeves DC, Goren EN, Akabas MH, Lummis SC. Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis. The Journal of Biological Chemistry. 276: 42035-42. PMID 11557761 DOI: 10.1074/Jbc.M106066200 |
0.31 |
|
| 2001 |
Gunthorpe MJ, Lummis SC. Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. The Journal of Biological Chemistry. 276: 10977-83. PMID 11439930 |
0.349 |
|
| 2001 |
Gunthorpe MJ, Lummis SC. Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. The Journal of Biological Chemistry. 276: 10977-83. PMID 11139582 DOI: 10.1074/jbc.M009575200 |
0.349 |
|
| 2000 |
Nayak SV, Rondé P, Spier AD, Lummis SC, Nichols RA. Nicotinic receptors co-localize with 5-HT(3) serotonin receptors on striatal nerve terminals. Neuropharmacology. 39: 2681-90. PMID 11044738 DOI: 10.1016/S0028-3908(00)00109-X |
0.398 |
|
| 2000 |
Spier AD, Lummis SC. The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain. The Journal of Biological Chemistry. 275: 5620-5. PMID 10681544 DOI: 10.1074/JBC.275.8.5620 |
0.414 |
|
| 2000 |
Gunthorpe MJ, Peters JA, Gill CH, Lambert JJ, Lummis SC. The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors. The Journal of Physiology. 522: 187-98. PMID 10639097 DOI: 10.1111/J.1469-7793.2000.00187.X |
0.385 |
|
| 1999 |
Gunthorpe MJ, Lummis SC. Diltiazem causes open channel block of recombinant 5-HT3 receptors. The Journal of Physiology. 713-22. PMID 10457085 DOI: 10.1111/j.1469-7793.1999.0713n.x |
0.388 |
|
| 1999 |
Nayak SV, Rondé P, Spier AD, Lummis SC, Nichols RA. Calcium changes induced by presynaptic 5-hydroxytryptamine-3 serotonin receptors on isolated terminals from various regions of the rat brain. Neuroscience. 91: 107-17. PMID 10336063 DOI: 10.1016/S0306-4522(98)00520-X |
0.382 |
|
| 1998 |
van Hooft JA, Spier AD, Yakel JL, Lummis SC, Vijverberg HP. Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels. Proceedings of the National Academy of Sciences of the United States of America. 95: 11456-61. PMID 9736758 DOI: 10.1073/Pnas.95.19.11456 |
0.374 |
|
| 1998 |
Niemeyer MI, Lummis SC. Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. British Journal of Pharmacology. 123: 661-6. PMID 9517385 DOI: 10.1038/sj.bjp.0701657 |
0.312 |
|
| 1997 |
Lummis SC, Baker J. Radioligand binding and photoaffinity labelling studies show a direct interaction of phenothiazines at 5-HT3 receptors. Neuropharmacology. 36: 665-70. PMID 9225292 DOI: 10.1016/S0028-3908(97)00054-3 |
0.373 |
|
| 1995 |
Green T, Stauffer KA, Lummis SC. Expression of recombinant homo-oligomeric 5-hydroxytryptamine3 receptors provides new insights into their maturation and structure. The Journal of Biological Chemistry. 270: 6056-61. PMID 7890738 DOI: 10.1074/JBC.270.11.6056 |
0.435 |
|
| 1995 |
Buckingham SD, Balk ML, Lummis SC, Jewess P, Sattelle DB. Actions of nitromethylenes on an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor. Neuropharmacology. 34: 591-7. PMID 7566494 DOI: 10.1016/0028-3908(95)00024-Z |
0.573 |
|
| 1994 |
Sepúlveda MI, Baker J, Lummis SC. Chlorpromazine and QX222 block 5-HT3 receptors in N1E-115 neuroblastoma cells. Neuropharmacology. 33: 493-9. PMID 7984288 DOI: 10.1016/0028-3908(94)90080-9 |
0.398 |
|
| 1993 |
Lummis SC, Sepúlveda MI, Kilpatrick GJ, Baker J. Characterization of [3H]meta-chlorophenylbiguanide binding to 5-HT3 receptors in N1E-115 neuroblastoma cells. European Journal of Pharmacology. 243: 7-11. PMID 8253126 DOI: 10.1016/0014-2999(93)90160-J |
0.321 |
|
| 1993 |
Buckingham SD, Lummis SC, Balk ML, Schroeder M, Sattelle DB. Actions of vesamicol on an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor. The Journal of Experimental Biology. 182: 255-64. PMID 8228781 |
0.593 |
|
| 1992 |
Lummis SC, Buckingham SD, Balk ML, Holyoke CW, Sattelle DB. Actions of a series of bisquaternary compounds on nicotinic acetylcholine receptors in insects: ligand binding and electrophysiological studies. Neuropharmacology. 31: 379-82. PMID 1522955 DOI: 10.1016/0028-3908(92)90070-6 |
0.596 |
|
| 1992 |
Boess FG, Sepúlveda MI, Lummis SC, Martin IL. 5-HT3 receptors in NG108-15 neuroblastoma x glioma cells: effect of the novel agonist 1-(m-chlorophenyl)-biguanide. Neuropharmacology. 31: 561-4. PMID 1407396 DOI: 10.1016/0028-3908(92)90188-U |
0.341 |
|
| 1992 |
Boess FG, Lummis SC, Martin IL. Molecular properties of 5-hydroxytryptamine3 receptor-type binding sites purified from NG108-15 cells. Journal of Neurochemistry. 59: 1692-701. PMID 1402914 DOI: 10.1111/j.1471-4159.1992.tb11000.x |
0.397 |
|
| 1992 |
Lummis S. Endogenous bacterial receptors should cause anxiety. Trends in Pharmacological Sciences. 13: 232. PMID 1321522 DOI: 10.1016/0165-6147(92)90072-E |
0.398 |
|
| 1991 |
Sattelle DB, Lummis SC, Wong JF, Rauh JJ. Pharmacology of insect GABA receptors. Neurochemical Research. 16: 363-74. PMID 1664063 DOI: 10.1007/BF00966100 |
0.628 |
|
| 1991 |
Lummis SC, Nicoletti G, Johnston GA, Holan G. Gamma-aminobutyric acid-modulated benzodiazepine binding sites in bacteria. Life Sciences. 49: 1079-86. PMID 1654489 DOI: 10.1016/0024-3205(91)90595-3 |
0.38 |
|
| 1990 |
Lummis SC, Nielsen M, Kilpatrick GJ, Martin IL. Target size of 5-HT3 receptors in N1E-115 neuroblastoma cells and rat brain. European Journal of Pharmacology. 189: 229-32. PMID 2253705 DOI: 10.1016/0922-4106(90)90027-U |
0.324 |
|
| 1990 |
Lummis SC, Kilpatrick GJ, Martin IL. Characterization of 5-HT3 receptors in intact N1E-115 neuroblastoma cells. European Journal of Pharmacology. 189: 223-7. PMID 2253704 DOI: 10.1016/0922-4106(90)90026-T |
0.383 |
|
| 1990 |
Rauh JJ, Lummis SC, Sattelle DB. Pharmacological and biochemical properties of insect GABA receptors. Trends in Pharmacological Sciences. 11: 325-9. PMID 2168103 DOI: 10.1016/0165-6147(90)90236-2 |
0.62 |
|
| 1990 |
Lummis SC, Gundlach AL, Johnston GA, Harper PA, Dodd PR. Increased gamma-aminobutyric acid receptor function in the cerebral cortex of myoclonic calves with an hereditary deficit in glycine/strychnine receptors. Journal of Neurochemistry. 55: 421-6. PMID 2164565 DOI: 10.1111/J.1471-4159.1990.Tb04153.X |
0.475 |
|
| 1990 |
Lummis SC, Martin IL. Characterization of soluble 5-hydroxytryptamine3 receptors from N1E115 neuroblastoma cells. Biochemical Society Transactions. 18: 1027-8. PMID 2083648 DOI: 10.1042/BST0181027 |
0.339 |
|
| 1990 |
Lummis SC. GABA receptors in insects. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 95: 1-8. PMID 1971549 DOI: 10.1016/0742-8413(90)90073-I |
0.441 |
|
| 1990 |
Lummis SC, Buckingham SD, Rauh JJ, Sattelle DB. Blocking actions of heptachlor at an insect central nervous system GABA receptor. Proceedings of the Royal Society of London. Series B, Biological Sciences. 240: 97-106. PMID 1694587 DOI: 10.1098/rspb.1990.0029 |
0.638 |
|
| 1990 |
Lummis S. GABA: Basic research and clinical applications Trends in Pharmacological Sciences. 11: 299. DOI: 10.1016/0165-6147(90)90015-Z |
0.333 |
|
| 1989 |
Lummis SC, Sattelle DB. Insect nervous system [(3)H]saxitoxin binding sites: characterization and target size. Neurochemistry International. 15: 391-5. PMID 20504511 DOI: 10.1016/0197-0186(89)90155-1 |
0.504 |
|
| 1989 |
Wafford KA, Lummis SC, Sattelle DB. Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 53-61. PMID 2474166 DOI: 10.1098/Rspb.1989.0036 |
0.665 |
|
| 1988 |
Lummis SC, Ellory JC, Sattelle DB. The cross-linking reagent dimethyl suberimate modifies the target size of an insect nervous system nicotinic acetylcholine receptor. Neuroscience Letters. 87: 145-50. PMID 3380333 DOI: 10.1016/0304-3940(88)90160-7 |
0.556 |
|
| 1988 |
Pinnock RD, Lummis SC, Chiappinelli VA, Sattelle DB. Kappa-bungarotoxin blocks an alpha-bungarotoxin-sensitive nicotinic receptor in the insect central nervous system. Brain Research. 458: 45-52. PMID 3208100 DOI: 10.1016/0006-8993(88)90494-5 |
0.677 |
|
| 1987 |
Lummis SC, Chow SC, Holan G, Johnston GA. gamma-Aminobutyric acid receptor ionophore complexes: differential effects of deltamethrin, dichlorodiphenyltrichloroethane, and some novel insecticides in a rat brain membrane preparation. Journal of Neurochemistry. 48: 689-94. PMID 3027258 DOI: 10.1111/J.1471-4159.1987.Tb05571.X |
0.441 |
|
| 1986 |
Lummis SC, Sattelle DB. Binding sites for [(3)H]GABA, [(3)H]flunitrazepam and [(35)S]TBPS in insect CNS. Neurochemistry International. 9: 287-93. PMID 20493128 DOI: 10.1016/0197-0186(86)90065-3 |
0.599 |
|
| 1985 |
Lummis SC, Sattelle DB. Insect central nervous system gamma-aminobutyric acid. Neuroscience Letters. 60: 13-8. PMID 2997671 DOI: 10.1016/0304-3940(85)90374-X |
0.617 |
|
| 1985 |
Lummis SC, Sattelle DB. Binding of N-[propionyl-3H]propionylated alpha-bungarotoxin and L-[benzilic-4,4'-3H] quinuclidinyl benzilate to CNS extracts of the cockroach Periplaneta americana. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 80: 75-83. PMID 2858352 DOI: 10.1016/0742-8413(85)90134-3 |
0.556 |
|
| 1984 |
Lummis SC, Sattelle DB, Ellory JC. Molecular weight estimates of insect cholinergic receptors by radiation inactivation. Neuroscience Letters. 44: 7-12. PMID 6717855 DOI: 10.1016/0304-3940(84)90212-X |
0.608 |
|
| 1981 |
Krogsgaard-Larsen P, Snowman A, Lummis SC, Olsen RW. Characterization of the binding of the GABA agonist [3H]piperidine-4-sulphonic acid to bovine brain synaptic membranes Journal of Neurochemistry. 37: 401-409. PMID 6267201 DOI: 10.1111/J.1471-4159.1981.Tb00469.X |
0.488 |
|
| 1981 |
Olsen RW, Bergman MO, Van Ness PC, Lummis SC, Watkins AE, Napias C, Greenlee DV. gamma-Aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sites. Molecular Pharmacology. 19: 217-27. PMID 6262615 |
0.393 |
|
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