| Year |
Citation |
Score |
| 2023 |
Walker NB, Yan Y, Tapia MA, Tucker BR, Thomas LN, George BE, West AM, Marotta CB, Lester HA, Dougherty DA, Holleran KM, Jones SR, Drenan RM. β2 nAChR activation on VTA DA neurons is sufficient for nicotine reinforcement in rats. Eneuro. PMID 37193602 DOI: 10.1523/ENEURO.0449-22.2023 |
0.708 |
|
| 2023 |
Maldifassi MC, Campello HR, Gallagher T, Lester HA, Dougherty DA. Human α6β4 nicotinic acetylcholine receptor: heterologous expression and agonist behavior provide insights into the immediate binding site. Molecular Pharmacology. PMID 37001996 DOI: 10.1124/molpharm.123.000672 |
0.315 |
|
| 2023 |
Nichols AL, Blumenfeld Z, Luebbert L, Knox HJ, Muthusamy AK, Marvin JS, Kim CH, Grant SN, Walton DP, Cohen BN, Hammar R, Looger L, Artursson P, Dougherty DA, Lester HA. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36868853 DOI: 10.1523/JNEUROSCI.1519-22.2022 |
0.768 |
|
| 2022 |
Beatty ZG, Muthusamy AK, Unger EK, Dougherty DA, Tian L, Looger LL, Shivange AV, Bera K, Lester HA, Nichols AL. Fluorescence Screens for Identifying Central Nervous System-Acting Drug-Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics. Bio-Protocol. 12. PMID 36532688 DOI: 10.21769/BioProtoc.4551 |
0.763 |
|
| 2022 |
Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AEM, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, ... ... Lester HA, et al. Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife. 11. PMID 36520038 DOI: 10.7554/eLife.85479 |
0.765 |
|
| 2022 |
Muthusamy AK, Kim CH, Virgil SC, Knox HJ, Marvin JS, Nichols AL, Cohen BN, Dougherty DA, Looger LL, Lester HA. Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids. Journal of the American Chemical Society. PMID 35446570 DOI: 10.1021/jacs.2c02323 |
0.778 |
|
| 2022 |
Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AE, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, ... ... Lester HA, et al. Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife. 11. PMID 34982029 DOI: 10.7554/eLife.74648 |
0.808 |
|
| 2021 |
Mulcahy MJ, Huard SM, Paulo JA, Wang JH, McKinney S, Marks MJ, Henderson BJ, Lester HA. Protein profiling in the habenula after chronic (-)-menthol exposure in mice. Journal of Neurochemistry. PMID 34407206 DOI: 10.1111/jnc.15495 |
0.73 |
|
| 2020 |
Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, ... ... Lester HA, et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. PMID 33333022 DOI: 10.1016/j.cell.2020.11.040 |
0.769 |
|
| 2020 |
Grant S, Muthusamy AK, Collazo A, Lester HA. Antagonists Pharmacologically Chaperone Opioid Receptors Biophysical Journal. 118: 27a. DOI: 10.1016/j.bpj.2019.11.328 |
0.719 |
|
| 2019 |
Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, ... ... Lester HA, et al. Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Frontiers in Cellular Neuroscience. 13: 499. PMID 31798415 DOI: 10.3389/Fncel.2019.00499 |
0.773 |
|
| 2019 |
Lester HA, Dougherty DA. Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem. Neuron. 104: 431-432. PMID 31697916 DOI: 10.1016/J.Neuron.2019.10.029 |
0.413 |
|
| 2019 |
Mulcahy MJ, Huard SM, Paulo JA, Wang JH, McKinney S, Henderson BJ, Lester HA. Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure. Journal of Proteome Research. PMID 31657575 DOI: 10.1021/Acs.Jproteome.9B00286 |
0.771 |
|
| 2019 |
Blom AEM, Rego Campello H, Lester HA, Gallagher T, Dougherty DA. Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor. Journal of the American Chemical Society. PMID 31518499 DOI: 10.1021/Jacs.9B06580 |
0.38 |
|
| 2019 |
Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin J, ... ... Lester HA, et al. Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. The Journal of General Physiology. PMID 30718376 DOI: 10.1085/Jgp.201812201 |
0.813 |
|
| 2019 |
Bavan S, Kim CH, Henderson BJ, Lester HA. Chronic menthol does not change stoichiometry or functional plasma membrane levels of mouse α3β4-containing nicotinic acetylcholine receptors. Molecular Pharmacology. PMID 30670481 DOI: 10.1124/Mol.118.114769 |
0.758 |
|
| 2019 |
Zhou C, Gu W, Wu H, Yan X, Deshpande P, Xiao C, Lester HA. Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs. Neuropharmacology. PMID 30660626 DOI: 10.1016/j.neuropharm.2019.01.015 |
0.337 |
|
| 2019 |
Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Kim CH, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA. Nicotinic Drugs in the Endoplasmic Reticulum: Beginning the Inside-out Pathway of Addiction and Therapy The Journal of General Physiology. DOI: 10.2210/Pdb6Efr/Pdb |
0.785 |
|
| 2018 |
Henderson BJ, Grant S, Chu BW, Shahoei R, Huard SM, Saladi SSM, Tajkhorshid E, Dougherty DA, Lester HA. Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing. Eneuro. 5. PMID 30627659 DOI: 10.1523/ENEURO.0465-18.2018 |
0.747 |
|
| 2018 |
Nichols AL, Noridomi K, Hughes CR, Jalali-Yazdi F, Eaton JB, Lai LH, Advani G, Lukas RJ, Lester HA, Chen L, Roberts RW. α1-FANGs-Protein Ligands Selective for the α-Bungarotoxin site of the α1-Nicotinic Acetylcholine Receptor. Acs Chemical Biology. PMID 30059207 DOI: 10.1021/Acschembio.8B00513 |
0.367 |
|
| 2018 |
Subramaniam SR, Magen I, Bove N, Zhu C, Lemesre V, Dutta G, Elias CJ, Lester HA, Chesselet MF. Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein. Neurobiology of Disease. PMID 29859873 DOI: 10.1016/J.Nbd.2018.05.018 |
0.307 |
|
| 2018 |
Banala S, Arvin MC, Bannon NM, Jin XT, Macklin JJ, Wang Y, Peng C, Zhao G, Marshall JJ, Gee KR, Wokosin DL, Kim VJ, McIntosh JM, Contractor A, Lester HA, et al. Photoactivatable drugs for nicotinic optopharmacology. Nature Methods. PMID 29578537 DOI: 10.1038/Nmeth.4637 |
0.808 |
|
| 2018 |
Muthusamy AK, Shivange AV, Nichols AL, Kamajaya A, Jeon J, Borden PM, Marvin JS, Unger EK, Bao H, Chapman ER, Tian L, Looger LL, Lester HA. Microscopy Using Fluorescent Drug Biosensors for “Inside-Out Pharmacology” Biophysical Journal. 114: 358a. DOI: 10.1016/J.Bpj.2017.11.1990 |
0.799 |
|
| 2018 |
Bavan S, Patowary S, Kim CH, Henderson BJ, Lester HA. Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors Biophysical Journal. 114: 296a. DOI: 10.1016/J.Bpj.2017.11.1691 |
0.773 |
|
| 2017 |
Parker RL, O'Neill HC, Henley BM, Wageman CR, Drenan RM, Marks MJ, Miwa JM, Grady SR, Lester HA. Deletion of lynx1 reduces the function of α6* nicotinic receptors. Plos One. 12: e0188715. PMID 29206881 DOI: 10.1371/Journal.Pone.0188715 |
0.821 |
|
| 2017 |
Tarren JR, Lester HA, Belmer A, Bartlett SE. Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala. Frontiers in Molecular Neuroscience. 10: 338. PMID 29114204 DOI: 10.3389/Fnmol.2017.00338 |
0.381 |
|
| 2017 |
Wall TR, Henderson BJ, Voren G, Wageman CR, Deshpande P, Cohen BN, Grady SR, Marks MJ, Yohannes D, Kenny PJ, Bencherif M, Lester HA. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Frontiers in Pharmacology. 8: 641. PMID 29033834 DOI: 10.3389/Fphar.2017.00641 |
0.774 |
|
| 2017 |
Mulcahy MJ, Lester HA. Granulocytes as models for human protein marker identification following nicotine exposure. Journal of Neurochemistry. 142: 151-161. PMID 28791704 DOI: 10.1111/jnc.14010 |
0.428 |
|
| 2017 |
Hurtado-Zavala JI, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, Stahlberg MA, Wagener RJ, Anderson K, Drenan RM, Lester HA, Miwa JM, Staiger JF, Fischer A, Dean C. TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nature Communications. 8: 15878. PMID 28722015 DOI: 10.1038/Ncomms15878 |
0.808 |
|
| 2017 |
Henderson BJ, Wall TR, Henley BM, Kim CH, McKinney S, Lester HA. Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28401925 DOI: 10.1038/Npp.2017.72 |
0.768 |
|
| 2017 |
Henley BM, Cohen BN, Kim CH, Gold HD, Srinivasan R, McKinney S, Deshpande P, Lester HA. Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression. Journal of Visualized Experiments : Jove. PMID 28287593 DOI: 10.3791/54981 |
0.544 |
|
| 2017 |
Post M, Lester HA, Dougherty DA. Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. Biochemistry. PMID 28287260 DOI: 10.1021/Acs.Biochem.7B00213 |
0.38 |
|
| 2016 |
Nichols WA, Henderson BJ, Marotta CB, Yu CY, Richards C, Dougherty DA, Lester HA, Cohen BN. Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression. Plos One. 11: e0158032. PMID 27336596 DOI: 10.1371/Journal.Pone.0158032 |
0.81 |
|
| 2016 |
Henderson BJ, Wall TR, Henley BM, Kim CH, Nichols WA, Moaddel R, Xiao C, Lester HA. Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 2957-74. PMID 26961950 DOI: 10.1523/Jneurosci.4194-15.2016 |
0.814 |
|
| 2016 |
Srinivasan R, Henley BM, Henderson BJ, Indersmitten T, Cohen BN, Kim CH, McKinney S, Deshpande P, Xiao C, Lester HA. Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 65-79. PMID 26740650 DOI: 10.1523/Jneurosci.2126-15.2016 |
0.818 |
|
| 2016 |
Patowary S, Mackey ED, McKinney SL, Deshpande P, Henderson BJ, Biener G, Raicu V, Lester HA. Effects of Menthol on α3β4∗ Nicotinic Receptors Biophysical Journal. 110: 603a. DOI: 10.1016/J.Bpj.2015.11.3221 |
0.77 |
|
| 2016 |
Post MR, Dougherty DA, Lester HA. Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor Biophysical Journal. 110: 603a. DOI: 10.1016/J.Bpj.2015.11.3220 |
0.458 |
|
| 2015 |
Marotta CB, Lester HA, Dougherty DA. An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors. Chemistry & Biology. 22: 1063-73. PMID 26211363 DOI: 10.1016/J.Chembiol.2015.06.018 |
0.423 |
|
| 2015 |
Lester HA, Lavis LD, Dougherty DA. Ketamine Inside Neurons? The American Journal of Psychiatry. appiajp201514121537. PMID 26183700 DOI: 10.1176/Appi.Ajp.2015.14121537 |
0.356 |
|
| 2015 |
Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, ... ... Lester HA, et al. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Science Translational Medicine. 7: 287ra72. PMID 25972004 DOI: 10.1126/Scitranslmed.3009986 |
0.748 |
|
| 2015 |
Post MR, Limapichat W, Lester HA, Dougherty DA. Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors. Neuropharmacology. 97: 376-382. PMID 25908401 DOI: 10.1016/J.Neuropharm.2015.04.009 |
0.453 |
|
| 2015 |
Xiao C, Miwa JM, Henderson BJ, Wang Y, Deshpande P, McKinney SL, Lester HA. Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3734-46. PMID 25740504 DOI: 10.1523/Jneurosci.3528-14.2015 |
0.806 |
|
| 2015 |
Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology. 96: 274-88. PMID 25701707 DOI: 10.1016/J.Neuropharm.2015.02.006 |
0.348 |
|
| 2015 |
Henderson BJ, Lester HA. Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology. 96: 178-93. PMID 25660637 DOI: 10.1016/J.Neuropharm.2015.01.022 |
0.784 |
|
| 2015 |
Miles TF, Lester HA, Dougherty DA. Allosteric activation of the 5-HT3AB receptor by mCPBG. Neuropharmacology. 91: 103-8. PMID 25541413 DOI: 10.1016/J.Neuropharm.2014.12.018 |
0.351 |
|
| 2014 |
Nichols WA, Henderson BJ, Yu C, Parker RL, Richards CI, Lester HA, Miwa JM. Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum. The Journal of Biological Chemistry. 289: 31423-32. PMID 25193667 DOI: 10.1074/Jbc.M114.573667 |
0.806 |
|
| 2014 |
Wang Y, Xiao C, Indersmitten T, Freedman R, Leonard S, Lester HA. The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7. The Journal of Biological Chemistry. 289: 26451-63. PMID 25056953 DOI: 10.1074/Jbc.M114.582858 |
0.407 |
|
| 2014 |
Daeffler KN, Lester HA, Dougherty DA. Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl. Acs Chemical Biology. 9: 2283-90. PMID 25051140 DOI: 10.1021/Cb500323D |
0.368 |
|
| 2014 |
Shih PY, Engle SE, Oh G, Deshpande P, Puskar NL, Lester HA, Drenan RM. Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9789-802. PMID 25031416 DOI: 10.1523/Jneurosci.0476-14.2014 |
0.82 |
|
| 2014 |
Kobayashi A, Parker RL, Wright AP, Brahem H, Ku P, Oliver KM, Walz A, Lester HA, Miwa JM. Lynx1 supports neuronal health in the mouse dorsal striatum during aging: an ultrastructural investigation. Journal of Molecular Neuroscience : Mn. 53: 525-36. PMID 25027556 DOI: 10.1007/S12031-014-0352-1 |
0.707 |
|
| 2014 |
Limapichat W, Dougherty DA, Lester HA. Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors. Molecular Pharmacology. 86: 263-74. PMID 24966348 DOI: 10.1124/Mol.114.093179 |
0.422 |
|
| 2014 |
Srinivasan R, Henderson BJ, Lester HA, Richards CI. Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 83: 20-9. PMID 24593907 DOI: 10.1016/J.Phrs.2014.02.005 |
0.822 |
|
| 2014 |
Marotta CB, Rreza I, Lester HA, Dougherty DA. Selective ligand behaviors provide new insights into agonist activation of nicotinic acetylcholine receptors. Acs Chemical Biology. 9: 1153-9. PMID 24564429 DOI: 10.1021/Cb400937D |
0.384 |
|
| 2014 |
Henderson BJ, Srinivasan R, Nichols WA, Dilworth CN, Gutierrez DF, Mackey ED, McKinney S, Drenan RM, Richards CI, Lester HA. Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. The Journal of General Physiology. 143: 51-66. PMID 24378908 DOI: 10.1085/Jgp.201311102 |
0.814 |
|
| 2014 |
Marotta CB, Dilworth CN, Lester HA, Dougherty DA. Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor. Neuropharmacology. 77: 342-9. PMID 24144909 DOI: 10.1016/J.Neuropharm.2013.09.028 |
0.432 |
|
| 2014 |
Marotta C, Lester HA, Dougherty DA. Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors Biophysical Journal. 106: 341a. DOI: 10.1016/J.Bpj.2013.11.1951 |
0.46 |
|
| 2014 |
Post MR, Lester HA, Dougherty DA. Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes Biophysical Journal. 106: 341a. DOI: 10.1016/J.Bpj.2013.11.1950 |
0.407 |
|
| 2013 |
Miles TF, Dougherty DA, Lester HA. The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane. Biophysical Journal. 105: 887-98. PMID 23972841 DOI: 10.1016/J.Bpj.2013.07.015 |
0.35 |
|
| 2013 |
Henley BM, Williams BA, Srinivasan R, Cohen BN, Xiao C, Mackey ED, Wold BJ, Lester HA. Transcriptional regulation by nicotine in dopaminergic neurons. Biochemical Pharmacology. 86: 1074-83. PMID 23939186 DOI: 10.1016/J.Bcp.2013.07.031 |
0.608 |
|
| 2013 |
Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE. The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. Plos One. 8: e68300. PMID 23869214 DOI: 10.1371/Journal.Pone.0068300 |
0.399 |
|
| 2013 |
Frazier SJ, Cohen BN, Lester HA. An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin. The Journal of Biological Chemistry. 288: 21029-42. PMID 23720773 DOI: 10.1074/Jbc.M112.423921 |
0.824 |
|
| 2013 |
Van Arnam EB, Blythe EE, Lester HA, Dougherty DA. An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline. Molecular Pharmacology. 84: 201-7. PMID 23680636 DOI: 10.1124/Mol.113.085795 |
0.397 |
|
| 2013 |
Limapichat W, Yu WY, Branigan E, Lester HA, Dougherty DA. Key binding interactions for memantine in the NMDA receptor. Acs Chemical Neuroscience. 4: 255-60. PMID 23421676 DOI: 10.1021/Cn300180A |
0.312 |
|
| 2013 |
Blum AP, Van Arnam EB, German LA, Lester HA, Dougherty DA. Binding interactions with the complementary subunit of nicotinic receptors. The Journal of Biological Chemistry. 288: 6991-7. PMID 23349463 DOI: 10.1074/Jbc.M112.439968 |
0.403 |
|
| 2013 |
O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ. Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function. Pharmacology, Biochemistry, and Behavior. 103: 603-21. PMID 23123803 DOI: 10.1016/J.Pbb.2012.10.014 |
0.44 |
|
| 2012 |
Miles TF, Bower KS, Lester HA, Dougherty DA. A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way. Acs Chemical Neuroscience. 3: 753-60. PMID 23077719 DOI: 10.1021/Cn3000586 |
0.321 |
|
| 2012 |
Srinivasan R, Richards CI, Dilworth C, Moss FJ, Dougherty DA, Lester HA. Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2. International Journal of Molecular Sciences. 13: 10022-40. PMID 22949846 DOI: 10.3390/Ijms130810022 |
0.633 |
|
| 2012 |
Daeffler KN, Lester HA, Dougherty DA. Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor. Journal of the American Chemical Society. 134: 14890-6. PMID 22897614 DOI: 10.1021/Ja304560X |
0.306 |
|
| 2012 |
Shapiro MG, Frazier SJ, Lester HA. Unparalleled control of neural activity using orthogonal pharmacogenetics. Acs Chemical Neuroscience. 3: 619-29. PMID 22896806 DOI: 10.1021/Cn300053Q |
0.772 |
|
| 2012 |
Drenan RM, Lester HA. Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations. Pharmacological Reviews. 64: 869-79. PMID 22885704 DOI: 10.1124/Pr.111.004671 |
0.74 |
|
| 2012 |
Miwa JM, Lester HA, Walz A. Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction. Physiology (Bethesda, Md.). 27: 187-99. PMID 22875450 DOI: 10.1152/Physiol.00002.2012 |
0.735 |
|
| 2012 |
Duffy NH, Lester HA, Dougherty DA. Ondansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesis. Acs Chemical Biology. 7: 1738-45. PMID 22873819 DOI: 10.1021/Cb300246J |
0.338 |
|
| 2012 |
Mackey ED, Engle SE, Kim MR, O'Neill HC, Wageman CR, Patzlaff NE, Wang Y, Grady SR, McIntosh JM, Marks MJ, Lester HA, Drenan RM. α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10226-37. PMID 22836257 DOI: 10.1523/Jneurosci.0007-12.2012 |
0.807 |
|
| 2012 |
Lester HA, Miwa JM, Srinivasan R. Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects. Biological Psychiatry. 72: 907-15. PMID 22771239 DOI: 10.1016/J.Biopsych.2012.05.020 |
0.773 |
|
| 2012 |
Tavares Xda S, Blum AP, Nakamura DT, Puskar NL, Shanata JA, Lester HA, Dougherty DA. Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor. Journal of the American Chemical Society. 134: 11474-80. PMID 22716019 DOI: 10.1021/Ja3011379 |
0.355 |
|
| 2012 |
Richards CI, Luong K, Srinivasan R, Turner SW, Dougherty DA, Korlach J, Lester HA. Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures. Nano Letters. 12: 3690-4. PMID 22668081 DOI: 10.1021/Nl301480H |
0.608 |
|
| 2012 |
Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS. Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents. Journal of Neurophysiology. 108: 1318-34. PMID 22649209 DOI: 10.1152/Jn.00907.2011 |
0.631 |
|
| 2012 |
Srinivasan R, Richards CI, Xiao C, Rhee D, Pantoja R, Dougherty DA, Miwa JM, Lester HA. Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response. Molecular Pharmacology. 81: 759-69. PMID 22379121 DOI: 10.1124/Mol.112.077792 |
0.805 |
|
| 2012 |
Puskar NL, Lester HA, Dougherty DA. Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor. Acs Chemical Biology. 7: 841-6. PMID 22296725 DOI: 10.1021/Cb200448J |
0.403 |
|
| 2012 |
Cohen BN, Mackey ED, Grady SR, McKinney S, Patzlaff NE, Wageman CR, McIntosh JM, Marks MJ, Lester HA, Drenan RM. Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior. Neuroscience. 200: 31-41. PMID 22079576 DOI: 10.1016/J.Neuroscience.2011.10.047 |
0.689 |
|
| 2012 |
Shanata JA, Frazier SJ, Lester HA, Dougherty DA. Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors. Methods in Molecular Biology (Clifton, N.J.). 796: 97-113. PMID 22052487 DOI: 10.1007/978-1-61779-334-9_6 |
0.796 |
|
| 2012 |
Murray TA, Bertrand D, Papke RL, George AA, Pantoja R, Srinivasan R, Liu Q, Wu J, Whiteaker P, Lester HA, Lukas RJ. α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces. Molecular Pharmacology. 81: 175-88. PMID 22039094 DOI: 10.1124/Mol.111.074088 |
0.826 |
|
| 2012 |
Dilworth CN, Marotta CB, Dougherty DA, Lester HA. Function of nAChRs Containing Alpha5 Subunits Biophysical Journal. 102: 117a. DOI: 10.1016/J.Bpj.2011.11.656 |
0.401 |
|
| 2012 |
Limapichat W, AlQazzaz M, Richards C, Lummis S, Dougherty D, Lester H. Alpha6∗ Nicotinic Receptors and P2X Receptors: Physical and Functional Interactions Biophysical Journal. 102: 113a. DOI: 10.1016/J.Bpj.2011.11.635 |
0.468 |
|
| 2012 |
Miles TF, Lester HA, Dougherty DA. Differential Functional Requirements at the Binding Site Between Serotonin and the Partial Agonist M-Chlorophenylbiguanide in Serotonin 3A Receptors Biophysical Journal. 102: 112a. DOI: 10.1016/J.Bpj.2011.11.630 |
0.375 |
|
| 2012 |
Frazier S, Cohen B, Lester H. Mutation of the Highly Conserved Pore-Lining Leucine Residue Increases Agonist Sensitivity of a Glutamate-Gated Chloride Channel Biophysical Journal. 102: 550a. DOI: 10.1016/J.Bpj.2011.11.3001 |
0.812 |
|
| 2011 |
Lummis SC, Thompson AJ, Bencherif M, Lester HA. Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor. The Journal of Pharmacology and Experimental Therapeutics. 339: 125-31. PMID 21775477 DOI: 10.1124/jpet.111.185306 |
0.328 |
|
| 2011 |
Richards CI, Srinivasan R, Xiao C, Mackey ED, Miwa JM, Lester HA. Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine. The Journal of Biological Chemistry. 286: 31241-9. PMID 21768117 DOI: 10.1074/Jbc.M111.256024 |
0.796 |
|
| 2011 |
Blum AP, Gleitsman KR, Lester HA, Dougherty DA. Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit. The Journal of Biological Chemistry. 286: 32251-8. PMID 21757705 DOI: 10.1074/Jbc.M111.254235 |
0.341 |
|
| 2011 |
Xiao C, Srinivasan R, Drenan RM, Mackey ED, McIntosh JM, Lester HA. Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells. Biochemical Pharmacology. 82: 852-61. PMID 21609715 DOI: 10.1016/J.Bcp.2011.05.005 |
0.811 |
|
| 2011 |
Miwa JM, Freedman R, Lester HA. Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. Neuron. 70: 20-33. PMID 21482353 DOI: 10.1016/J.Neuron.2011.03.014 |
0.737 |
|
| 2011 |
Puskar NL, Xiu X, Lester HA, Dougherty DA. Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes. The Journal of Biological Chemistry. 286: 14618-27. PMID 21343288 DOI: 10.1074/Jbc.M110.206565 |
0.445 |
|
| 2011 |
Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC. A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Molecular Pharmacology. 79: 742-8. PMID 21266487 DOI: 10.1124/Mol.110.069583 |
0.331 |
|
| 2011 |
Srinivasan R, Pantoja R, Moss FJ, Mackey ED, Son CD, Miwa J, Lester HA. Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. The Journal of General Physiology. 137: 59-79. PMID 21187334 DOI: 10.1085/Jgp.201010532 |
0.797 |
|
| 2011 |
Xu J, Cohen BN, Zhu Y, Dziewczapolski G, Panda S, Lester HA, Heinemann SF, Contractor A. Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor. Molecular Psychiatry. 16: 1048-61. PMID 20603624 DOI: 10.1038/Mp.2010.78 |
0.366 |
|
| 2011 |
Parker R, Rhee D, Lester H, Miwa J. Lynx1 balances neuronal activity through nicotinic acetylcholine receptor modulation Biochemical Pharmacology. 82: 1037. DOI: 10.1016/J.Bcp.2011.07.037 |
0.745 |
|
| 2011 |
Drenan RM, Mackey ED, Grady SR, Patzlaff NE, Wageman CR, McIntosh JM, Marks MJ, Lester HA. α6* nAChR expression and function in brain areas influencing DA transmission probed with α6-GFP transgenic mice Biochemical Pharmacology. 82: 1035-1036. DOI: 10.1016/J.Bcp.2011.07.033 |
0.683 |
|
| 2010 |
Thompson AJ, Lester HA, Lummis SC. The structural basis of function in Cys-loop receptors. Quarterly Reviews of Biophysics. 43: 449-99. PMID 20849671 DOI: 10.1017/S0033583510000168 |
0.394 |
|
| 2010 |
Drenan RM, Grady SR, Steele AD, McKinney S, Patzlaff NE, McIntosh JM, Marks MJ, Miwa JM, Lester HA. Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9877-89. PMID 20660270 DOI: 10.1523/Jneurosci.2056-10.2010 |
0.802 |
|
| 2010 |
Blum AP, Lester HA, Dougherty DA. Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proceedings of the National Academy of Sciences of the United States of America. 107: 13206-11. PMID 20616056 DOI: 10.1073/Pnas.1007140107 |
0.366 |
|
| 2010 |
Hanek AP, Lester HA, Dougherty DA. Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation. Molecular Pharmacology. 78: 29-35. PMID 20363860 DOI: 10.1124/Mol.109.059832 |
0.343 |
|
| 2010 |
Grady SR, Drenan RM, Breining SR, Yohannes D, Wageman CR, Fedorov NB, McKinney S, Whiteaker P, Bencherif M, Lester HA, Marks MJ. Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors. Neuropharmacology. 58: 1054-66. PMID 20114055 DOI: 10.1016/J.Neuropharm.2010.01.013 |
0.705 |
|
| 2010 |
Limapichat W, Lester HA, Dougherty DA. Chemical scale studies of the Phe-Pro conserved motif in the cys loop of Cys loop receptors. The Journal of Biological Chemistry. 285: 8976-84. PMID 20068044 DOI: 10.1074/Jbc.M109.060939 |
0.317 |
|
| 2010 |
Zhao-Shea R, Cohen BN, Just H, McClure-Begley T, Whiteaker P, Grady SR, Salminen O, Gardner PD, Lester HA, Tapper AR. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 49-57. PMID 19720621 DOI: 10.1096/Fj.09-137034 |
0.416 |
|
| 2010 |
Puskar NL, Xiu X, Lester HA, Dougherty DA. Thinking Outside the Box: Residues that Shape the Agonist Binding Site of Nicotinic Acetylcholine Receptors Biophysical Journal. 98: 132a. DOI: 10.1016/J.Bpj.2009.12.715 |
0.414 |
|
| 2010 |
Blum AP, Puskar NL, Tavares XDS, Nakamura DT, Xiu X, Lester HA, Dougherty DA. The Nicotinic Pharmacophore - Binding Interactions in the Neuronal α4β2 Receptor Biophysical Journal. 98: 132a. DOI: 10.1016/J.Bpj.2009.12.713 |
0.409 |
|
| 2010 |
Shanata JA, Lester HA, Dougherty DA. Single-Channel Recording of Muscle and Neuronal Nicotinic Acetylcholine Receptors: Implications for Allosteric Transitions Biophysical Journal. 98: 129a. DOI: 10.1016/J.Bpj.2009.12.700 |
0.474 |
|
| 2010 |
Thompson MW, McMenimen KA, Lester HA, Dougherty D. A Functional Probe of Ligand Binding and Agonist Efficacy in Ionotropic Glutamate Receptors Biophysical Journal. 98: 526a. DOI: 10.1016/J.Bpj.2009.12.2857 |
0.349 |
|
| 2010 |
Van Arnam EB, McCleary KN, Torrice MM, Bower K, Jensen EH, Lester HA, Dougherty DA. Probing the Binding Sites and Transmembrane Prolines of GPCRs Using Unnatural Amino Acids Biophysical Journal. 98: 292a. DOI: 10.1016/J.Bpj.2009.12.1589 |
0.367 |
|
| 2009 |
Moss FJ, Imoukhuede PI, Scott K, Hu J, Jankowsky JL, Quick MW, Lester HA. GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET. The Journal of General Physiology. 134: 489-521. PMID 19948998 DOI: 10.1085/Jgp.200910314 |
0.775 |
|
| 2009 |
Xiao C, Nashmi R, McKinney S, Cai H, McIntosh JM, Lester HA. Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12428-39. PMID 19812319 DOI: 10.1523/JNEUROSCI.2939-09.2009 |
0.412 |
|
| 2009 |
Torrice MM, Bower KS, Lester HA, Dougherty DA. Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids. Proceedings of the National Academy of Sciences of the United States of America. 106: 11919-24. PMID 19581583 DOI: 10.1073/Pnas.0903260106 |
0.374 |
|
| 2009 |
Breining SR, Bencherif M, Grady SR, Whiteaker P, Marks MJ, Wageman CR, Lester HA, Yohannes D. Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype. Bioorganic & Medicinal Chemistry Letters. 19: 4359-63. PMID 19560354 DOI: 10.1016/J.Bmcl.2009.05.085 |
0.418 |
|
| 2009 |
Gleitsman KR, Lester HA, Dougherty DA. Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor. Chembiochem : a European Journal of Chemical Biology. 10: 1385-91. PMID 19405066 DOI: 10.1002/Cbic.200900092 |
0.403 |
|
| 2009 |
Gleitsman KR, Shanata JA, Frazier SJ, Lester HA, Dougherty DA. Long-range coupling in an allosteric receptor revealed by mutant cycle analysis. Biophysical Journal. 96: 3168-78. PMID 19383461 DOI: 10.1016/J.Bpj.2008.12.3949 |
0.813 |
|
| 2009 |
Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The Aaps Journal. 11: 167-77. PMID 19280351 DOI: 10.1208/S12248-009-9090-7 |
0.801 |
|
| 2009 |
Xiu X, Puskar NL, Shanata JA, Lester HA, Dougherty DA. Nicotine binding to brain receptors requires a strong cation-pi interaction. Nature. 458: 534-7. PMID 19252481 DOI: 10.1038/Nature07768 |
0.418 |
|
| 2009 |
Son CD, Moss FJ, Cohen BN, Lester HA. Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy. Molecular Pharmacology. 75: 1137-48. PMID 19237585 DOI: 10.1124/mol.108.054494 |
0.391 |
|
| 2009 |
Pantoja R, Rodriguez EA, Dibas MI, Dougherty DA, Lester HA. Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors. Biophysical Journal. 96: 226-37. PMID 19134478 DOI: 10.1016/J.Bpj.2008.09.034 |
0.744 |
|
| 2009 |
Fonck C, Nashmi R, Salas R, Zhou C, Huang Q, De Biasi M, Lester RA, Lester HA. Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula. Neuropharmacology. 56: 247-53. PMID 18789953 DOI: 10.1016/j.neuropharm.2008.08.021 |
0.696 |
|
| 2009 |
Srinivasan R, Pantoja R, Kadambi S, Lester HA. Cellular Basis Of Nicotine-induced nAChr Upregulation Biophysical Journal. 96: 165a. DOI: 10.1016/J.Bpj.2008.12.763 |
0.607 |
|
| 2009 |
Pantoja R, Srinivasan R, Moss FJ, Kadambi S, Imoukhuede PI, Lester HA. Characterizing Nicotine-Induced α4∗ nAChR Upregulation with Fluorescence Microscopy Biophysical Journal. 96: 105a. DOI: 10.1016/J.Bpj.2008.12.453 |
0.602 |
|
| 2009 |
Moss FJ, Imoukheude PI, Hu J, Jankowsky JL, Quick MW, Lester HA. Quantification Of Sensitized FRET From Fluorescent GAT1 γ-aminobutyric Acid Transporters Distinguishes Between Subsurface And Plasma Membrane Resident Oligomers And Predicts Function Biophysical Journal. 96: 271a. DOI: 10.1016/J.Bpj.2008.12.1341 |
0.775 |
|
| 2009 |
Pantoja R, Rodriguez EA, Tzlil S, Wade L, Dougherty DA, Lester HA. Characterizing the Architecture of Nicotinic Receptors with Quantum Dot-Based Fluorescence Microscopy Biophysical Journal. 96: 35a. DOI: 10.1016/J.Bpj.2008.12.073 |
0.742 |
|
| 2009 |
Pantoja R, Srinivasan R, Kadambi S, Mackey ED, Tzlil S, Moss FJ, Lester HA. Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: High-resolution imaging Biochemical Pharmacology. 78: 900-901. DOI: 10.1016/J.Bcp.2009.06.033 |
0.593 |
|
| 2009 |
Srinivasan R, Pantoja R, Kadambi S, Mackey ED, Tzlil S, Moss FJ, Lester HA. Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: Compartments and stoichiometries Biochemical Pharmacology. 78: 900. DOI: 10.1016/J.Bcp.2009.06.032 |
0.625 |
|
| 2008 |
Gleitsman KR, Kedrowski SM, Lester HA, Dougherty DA. An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating. The Journal of Biological Chemistry. 283: 35638-43. PMID 18952603 DOI: 10.1074/Jbc.M807226200 |
0.379 |
|
| 2008 |
Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA. A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10937-42. PMID 18945901 DOI: 10.1523/Jneurosci.2540-08.2008 |
0.346 |
|
| 2008 |
Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, Bupp S, Heintz N, McIntosh JM, Bencherif M, Marks MJ, Lester HA. In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors. Neuron. 60: 123-36. PMID 18940593 DOI: 10.1016/J.Neuron.2008.09.009 |
0.809 |
|
| 2008 |
Hanek AP, Lester HA, Dougherty DA. A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor. Journal of the American Chemical Society. 130: 13216-8. PMID 18781739 DOI: 10.1021/Ja8015457 |
0.379 |
|
| 2008 |
Price KL, Bower KS, Thompson AJ, Lester HA, Dougherty DA, Lummis SC. A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry. 47: 6370-7. PMID 18498149 DOI: 10.1021/Bi800222N |
0.323 |
|
| 2008 |
Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 519-28. PMID 18184794 DOI: 10.1523/Jneurosci.3666-07.2008 |
0.427 |
|
| 2008 |
Drenan RM, Nashmi R, Imoukhuede P, Just H, McKinney S, Lester HA. Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits. Molecular Pharmacology. 73: 27-41. PMID 17932221 DOI: 10.1124/Mol.107.039180 |
0.742 |
|
| 2007 |
Pless SA, Dibas MI, Lester HA, Lynch JW. Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. The Journal of Biological Chemistry. 282: 36057-67. PMID 17911099 DOI: 10.1074/Jbc.M706468200 |
0.37 |
|
| 2007 |
Teper Y, Whyte D, Cahir E, Lester HA, Grady SR, Marks MJ, Cohen BN, Fonck C, McClure-Begley T, McIntosh JM, Labarca C, Lawrence A, Chen F, Gantois I, Davies PJ, et al. Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10128-42. PMID 17881519 DOI: 10.1523/Jneurosci.3042-07.2007 |
0.388 |
|
| 2007 |
Tapper AR, McKinney SL, Marks MJ, Lester HA. Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiological Genomics. 31: 422-8. PMID 17712039 DOI: 10.1152/physiolgenomics.00063.2007 |
0.357 |
|
| 2007 |
Rodriguez EA, Lester HA, Dougherty DA. Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation. Rna (New York, N.Y.). 13: 1703-14. PMID 17698638 DOI: 10.1261/Rna.666807 |
0.677 |
|
| 2007 |
Rodriguez EA, Lester HA, Dougherty DA. Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: evaluating suppression efficiency. Rna (New York, N.Y.). 13: 1715-22. PMID 17698637 DOI: 10.1261/Rna.667607 |
0.68 |
|
| 2007 |
Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, Whiteaker P, Huang Q, McClure-Begley T, Lindstrom JM, Labarca C, Collins AC, Marks MJ, Lester HA. Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8202-18. PMID 17670967 DOI: 10.1523/Jneurosci.2199-07.2007 |
0.438 |
|
| 2007 |
Nashmi R, Lester H. Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation Biochemical Pharmacology. 74: 1145-1154. PMID 17662697 DOI: 10.1016/J.Bcp.2007.06.040 |
0.468 |
|
| 2007 |
Wang J, Lester HA, Dougherty DA. Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway. The Journal of Biological Chemistry. 282: 26210-6. PMID 17606618 DOI: 10.1074/Jbc.M702314200 |
0.354 |
|
| 2007 |
Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. The Journal of Biological Chemistry. 282: 22707-20. PMID 17556372 DOI: 10.1074/Jbc.M611050200 |
0.626 |
|
| 2007 |
Lerchner W, Xiao C, Nashmi R, Slimko EM, van Trigt L, Lester HA, Anderson DJ. Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel. Neuron. 54: 35-49. PMID 17408576 DOI: 10.1016/J.Neuron.2007.02.030 |
0.494 |
|
| 2007 |
Damaj MI, Fonck C, Marks MJ, Deshpande P, Labarca C, Lester HA, Collins AC, Martin BR. Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 321: 1161-9. PMID 17371806 DOI: 10.1124/jpet.106.112649 |
0.406 |
|
| 2007 |
Cashin AL, Torrice MM, McMenimen KA, Lester HA, Dougherty DA. Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor. Biochemistry. 46: 630-9. PMID 17223685 DOI: 10.1021/Bi061638B |
0.369 |
|
| 2006 |
Nashmi R, Lester HA. CNS localization of neuronal nicotinic receptors. Journal of Molecular Neuroscience : Mn. 30: 181-4. PMID 17192671 DOI: 10.1385/Jmn:30:1:181 |
0.462 |
|
| 2006 |
McMenimen KA, Dougherty DA, Lester HA, Petersson EJ. Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis. Acs Chemical Biology. 1: 227-34. PMID 17163677 DOI: 10.1021/Cb6000944 |
0.32 |
|
| 2006 |
Ahern CA, Eastwood AL, Lester HA, Dougherty DA, Horn R. A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. The Journal of General Physiology. 128: 649-57. PMID 17130518 DOI: 10.1085/Jgp.200609654 |
0.346 |
|
| 2006 |
Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N. The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron. 51: 587-600. PMID 16950157 DOI: 10.1016/J.Neuron.2006.07.025 |
0.791 |
|
| 2006 |
Rodriguez EA, Lester HA, Dougherty DA. In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression. Proceedings of the National Academy of Sciences of the United States of America. 103: 8650-5. PMID 16728509 DOI: 10.1073/Pnas.0510817103 |
0.693 |
|
| 2006 |
Schwarz J, Schwarz SC, Dorigo O, Stützer A, Wegner F, Labarca C, Deshpande P, Gil JS, Berk AJ, Lester HA. Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 935-46. PMID 16675851 DOI: 10.1096/Fj.05-5497Com |
0.363 |
|
| 2006 |
Sokolova IV, Lester HA, Davidson N. Postsynaptic mechanisms are essential for forskolin-induced potentiation of synaptic transmission. Journal of Neurophysiology. 95: 2570-9. PMID 16394076 DOI: 10.1152/jn.00617.2005 |
0.581 |
|
| 2005 |
Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar DA, Rodrigues-Pinguet N, Deshpande P, McKinney S, Kwoh S, Munoz J, Labarca C, Collins AC, Marks MJ, Lester HA. Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11396-411. PMID 16339034 DOI: 10.1523/Jneurosci.3597-05.2005 |
0.681 |
|
| 2005 |
Lummis SC, Beene DL, Lee LW, Lester HA, Broadhurst RW, Dougherty DA. Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature. 438: 248-52. PMID 16281040 DOI: 10.1038/Nature04130 |
0.353 |
|
| 2005 |
Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. Plos Medicine. 2: e355. PMID 16279840 DOI: 10.1371/Journal.Pmed.0020355 |
0.611 |
|
| 2005 |
Xiu X, Hanek AP, Wang J, Lester HA, Dougherty DA. A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. The Journal of Biological Chemistry. 280: 41655-66. PMID 16216879 DOI: 10.1074/Jbc.M508635200 |
0.357 |
|
| 2005 |
Lummis SC, L Beene D, Harrison NJ, Lester HA, Dougherty DA. A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor. Chemistry & Biology. 12: 993-7. PMID 16183023 DOI: 10.1016/J.Chembiol.2005.06.012 |
0.358 |
|
| 2005 |
Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA. An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6911-20. PMID 16033901 DOI: 10.1523/Jneurosci.0561-05.2005 |
0.652 |
|
| 2005 |
Rodrigues-Pinguet NO, Pinguet TJ, Figl A, Lester HA, Cohen BN. Mutations linked to autosomal dominant nocturnal frontal lobe epilepsy affect allosteric Ca2+ activation of the alpha 4 beta 2 nicotinic acetylcholine receptor. Molecular Pharmacology. 68: 487-501. PMID 15901849 DOI: 10.1124/mol.105.011155 |
0.319 |
|
| 2005 |
Chiu CS, Brickley S, Jensen K, Southwell A, Mckinney S, Cull-Candy S, Mody I, Lester HA. GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3234-45. PMID 15788781 DOI: 10.1523/Jneurosci.3364-04.2005 |
0.654 |
|
| 2005 |
Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J. D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2157-65. PMID 15728856 DOI: 10.1523/Jneurosci.2840-04.2005 |
0.356 |
|
| 2005 |
Cashin AL, Petersson EJ, Lester HA, Dougherty DA. Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor. Journal of the American Chemical Society. 127: 350-6. PMID 15631485 DOI: 10.1021/Ja0461771 |
0.397 |
|
| 2005 |
Nashmi R, Fraser SE, Lester HA, Dickinson ME. FRET Measurements Using Multispectral Imaging Molecular Imaging. 180-192. DOI: 10.1016/B978-019517720-6.50019-5 |
0.314 |
|
| 2004 |
Tapper AR, McKinney SL, Nashmi R, Schwarz J, Deshpande P, Labarca C, Whiteaker P, Marks MJ, Collins AC, Lester HA. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science (New York, N.Y.). 306: 1029-32. PMID 15528443 DOI: 10.1126/Science.1099420 |
0.416 |
|
| 2004 |
Diba K, Lester HA, Koch C. Intrinsic noise in cultured hippocampal neurons: experiment and modeling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9723-33. PMID 15509761 DOI: 10.1523/Jneurosci.1721-04.2004 |
0.697 |
|
| 2004 |
Beene DL, Price KL, Lester HA, Dougherty DA, Lummis SC. Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9097-104. PMID 15483128 DOI: 10.1523/Jneurosci.2429-04.2004 |
0.357 |
|
| 2004 |
Becker CF, Clayton D, Shapovalov G, Lester HA, Kochendoerfer GG. On-resin assembly of a linkerless lanthanide(III)-based luminescence label and its application to the total synthesis of site-specifically labeled mechanosensitive channels. Bioconjugate Chemistry. 15: 1118-24. PMID 15366968 DOI: 10.1021/bc0498828 |
0.326 |
|
| 2004 |
Dahan DS, Dibas MI, Petersson EJ, Auyeung VC, Chanda B, Bezanilla F, Dougherty DA, Lester HA. A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. Proceedings of the National Academy of Sciences of the United States of America. 101: 10195-200. PMID 15218096 DOI: 10.1073/Pnas.0301885101 |
0.58 |
|
| 2004 |
Bhattacharya A, Dang H, Zhu QM, Schnegelsberg B, Rozengurt N, Cain G, Prantil R, Vorp DA, Guy N, Julius D, Ford AP, Lester HA, Cockayne DA. Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5537-48. PMID 15201326 DOI: 10.1523/Jneurosci.5658-03.2004 |
0.348 |
|
| 2004 |
Orb S, Wieacker J, Labarca C, Fonck C, Lester HA, Schwarz J. Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally. Physiological Genomics. 18: 299-307. PMID 15199190 DOI: 10.1152/physiolgenomics.00012.2004 |
0.401 |
|
| 2004 |
Lester HA, Dibas MI, Dahan DS, Leite JF, Dougherty DA. Cys-loop receptors: new twists and turns. Trends in Neurosciences. 27: 329-36. PMID 15165737 DOI: 10.1016/J.Tins.2004.04.002 |
0.363 |
|
| 2004 |
Clayton D, Shapovalov G, Maurer JA, Dougherty DA, Lester HA, Kochendoerfer GG. Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 101: 4764-9. PMID 15041744 DOI: 10.1073/Pnas.0305693101 |
0.349 |
|
| 2003 |
Owens JC, Balogh SA, McClure-Begley TD, Butt CM, Labarca C, Lester HA, Picciotto MR, Wehner JM, Collins AC. Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response. Alcoholism, Clinical and Experimental Research. 27: 1867-75. PMID 14691373 DOI: 10.1097/01.Alc.0000102700.72447.0F |
0.564 |
|
| 2003 |
Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA. Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11554-67. PMID 14684858 DOI: 10.1523/Jneurosci.23-37-11554.2003 |
0.596 |
|
| 2003 |
Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, ... ... Lester HA, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/Pr.55.4.9 |
0.592 |
|
| 2003 |
Storch A, Lester HA, Boehm BO, Schwarz J. Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells. Journal of Chemical Neuroanatomy. 26: 133-42. PMID 14599663 DOI: 10.1016/S0891-0618(03)00067-X |
0.321 |
|
| 2003 |
Lester HA, Fonck C, Tapper AR, McKinney S, Damaj MI, Balogh S, Owens J, Wehner JM, Collins AC, Labarca C. Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action. Current Opinion in Drug Discovery & Development. 6: 633-9. PMID 14579512 |
0.305 |
|
| 2003 |
Leite JF, Blanton MP, Shahgholi M, Dougherty DA, Lester HA. Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 100: 13054-9. PMID 14569028 DOI: 10.1073/Pnas.2133028100 |
0.376 |
|
| 2003 |
Monahan SL, Lester HA, Dougherty DA. Site-specific incorporation of unnatural amino acids into receptors expressed in Mammalian cells. Chemistry & Biology. 10: 573-80. PMID 12837390 DOI: 10.1016/S1074-5521(03)00124-8 |
0.375 |
|
| 2003 |
Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, ... ... Lester HA, et al. RGS9 modulates dopamine signaling in the basal ganglia. Neuron. 38: 941-52. PMID 12818179 DOI: 10.1016/S0896-6273(03)00321-0 |
0.326 |
|
| 2003 |
Jensen K, Chiu CS, Sokolova I, Lester HA, Mody I. GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. Journal of Neurophysiology. 90: 2690-701. PMID 12815026 DOI: 10.1152/jn.00240.2003 |
0.321 |
|
| 2003 |
Mu TW, Lester HA, Dougherty DA. Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge? Journal of the American Chemical Society. 125: 6850-1. PMID 12783521 DOI: 10.1021/Ja0348086 |
0.349 |
|
| 2003 |
Rodrigues-Pinguet N, Jia L, Li M, Figl A, Klaassen A, Truong A, Lester HA, Cohen BN. Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response. The Journal of Physiology. 550: 11-26. PMID 12754307 DOI: 10.1113/Jphysiol.2003.036681 |
0.319 |
|
| 2003 |
Yu TP, Lester HA, Davidson N. Requirement of a critical period of GABAergic receptor blockade for induction of a cAMP-mediated long-term depression at CA3-CA1 synapses. Synapse (New York, N.Y.). 49: 12-9. PMID 12710011 DOI: 10.1002/syn.10207 |
0.57 |
|
| 2003 |
Shapovalov G, Bass R, Rees DC, Lester HA. Open-state disulfide crosslinking between Mycobacterium tuberculosis mechanosensitive channel subunits. Biophysical Journal. 84: 2357-65. PMID 12668444 DOI: 10.1016/S0006-3495(03)75041-3 |
0.325 |
|
| 2003 |
Slimko EM, Lester HA. Codon optimization of Caenorhabditis elegans GluCl ion channel genes for mammalian cells dramatically improves expression levels. Journal of Neuroscience Methods. 124: 75-81. PMID 12648766 DOI: 10.1016/S0165-0270(02)00362-X |
0.389 |
|
| 2003 |
Petersson EJ, Brandt GS, Zacharias NM, Dougherty DA, Lester HA. Caging proteins through unnatural amino acid mutagenesis. Methods in Enzymology. 360: 258-73. PMID 12622154 DOI: 10.1016/S0076-6879(03)60114-X |
0.313 |
|
| 2003 |
Rozengurt N, Lopez I, Chiu CS, Kofuji P, Lester HA, Neusch C. Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit. Hearing Research. 177: 71-80. PMID 12618319 DOI: 10.1016/S0378-5955(02)00799-2 |
0.655 |
|
| 2003 |
Leite JF, Rodrigues-Pinguet N, Lester HA. Insights into channel function via channel dysfunction. The Journal of Clinical Investigation. 111: 436-7. PMID 12588879 DOI: 10.1172/JCI17882 |
0.393 |
|
| 2003 |
Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, Lester HA. Increased Sensitivity to Agonist-Induced Seizures, Straub Tail, and Hippocampal Theta Rhythm in Knock-In Mice Carrying Hypersensitive α4 Nicotinic Receptors The Journal of Neuroscience. 23: 2582-2590. DOI: 10.1523/Jneurosci.23-07-02582.2003 |
0.387 |
|
| 2003 |
Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA. Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons Journal of Neuroscience. 23: 11554-11567. |
0.317 |
|
| 2002 |
Chiu CS, Jensen K, Sokolova I, Wang D, Li M, Deshpande P, Davidson N, Mody I, Quick MW, Quake SR, Lester HA. Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10251-66. PMID 12451126 DOI: 10.1523/Jneurosci.22-23-10251.2002 |
0.747 |
|
| 2002 |
Petersson EJ, Choi A, Dahan DS, Lester HA, Dougherty DA. A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding. Journal of the American Chemical Society. 124: 12662-3. PMID 12392404 DOI: 10.1021/Ja028206I |
0.407 |
|
| 2002 |
Li P, Slimko EM, Lester HA. Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel. Febs Letters. 528: 77-82. PMID 12297283 DOI: 10.1016/S0014-5793(02)03245-3 |
0.41 |
|
| 2002 |
Slimko EM, McKinney S, Anderson DJ, Davidson N, Lester HA. Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7373-9. PMID 12196558 |
0.672 |
|
| 2002 |
Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, Dougherty DA. Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry. 41: 10262-9. PMID 12162741 DOI: 10.1021/Bi020266D |
0.41 |
|
| 2002 |
Eickhorst AN, Berson A, Cockayne D, Lester HA, Khakh BS. Control of P2X(2) channel permeability by the cytosolic domain. The Journal of General Physiology. 120: 119-31. PMID 12149275 DOI: 10.1085/Jgp.20028535 |
0.614 |
|
| 2002 |
Nadeau H, Lester HA. NRSF causes cAMP-sensitive suppression of sodium current in cultured hippocampal neurons. Journal of Neurophysiology. 88: 409-21. PMID 12091564 DOI: 10.1152/Jn.2002.88.1.409 |
0.366 |
|
| 2002 |
Li M, Farley RA, Lester HA. Voltage-dependent transient currents of human and rat 5-HT transporters (SERT) are blocked by HEPES and ion channel ligands. Febs Letters. 513: 247-52. PMID 11904159 DOI: 10.1016/S0014-5793(02)02322-0 |
0.339 |
|
| 2002 |
Kovoor A, Lester HA. Gi Irks GIRKs. Neuron. 33: 6-8. PMID 11779473 DOI: 10.1016/S0896-6273(01)00572-4 |
0.332 |
|
| 2002 |
Slimko EM, McKinney S, Anderson DJ, Davidson N, Lester HA. Selective Electrical Silencing of Mammalian NeuronsIn Vitroby the Use of Invertebrate Ligand-Gated Chloride Channels The Journal of Neuroscience. 22: 7373-7379. DOI: 10.1523/JNEUROSCI.22-17-07373.2002 |
0.694 |
|
| 2001 |
Li M, Lester HA. Ion channel diseases of the central nervous system. Cns Drug Reviews. 7: 214-40. PMID 11474425 DOI: 10.1111/J.1527-3458.2001.Tb00196.X |
0.316 |
|
| 2001 |
Neusch C, Rozengurt N, Jacobs RE, Lester HA, Kofuji P. Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5429-38. PMID 11466414 DOI: 10.1523/Jneurosci.21-15-05429.2001 |
0.631 |
|
| 2001 |
Philipson KD, Gallivan JP, Brandt GS, Dougherty DA, Lester HA. Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor. American Journal of Physiology. Cell Physiology. 281: C195-206. PMID 11401842 DOI: 10.1152/Ajpcell.2001.281.1.C195 |
0.421 |
|
| 2001 |
Dougherty DA, Lester HA. Neurobiology. Snails, synapses and smokers. Nature. 411: 252-3, 255. PMID 11357112 DOI: 10.1038/35077192 |
0.35 |
|
| 2001 |
Yu TP, McKinney S, Lester HA, Davidson N. Gamma-aminobutyric acid type A receptors modulate cAMP-mediated long-term potentiation and long-term depression at monosynaptic CA3-CA1 synapses. Proceedings of the National Academy of Sciences of the United States of America. 98: 5264-9. PMID 11296264 DOI: 10.1073/pnas.091093998 |
0.581 |
|
| 2001 |
Khakh BS, Smith WB, Chiu CS, Ju D, Davidson N, Lester HA. Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X2-green fluorescent protein receptors. Proceedings of the National Academy of Sciences of the United States of America. 98: 5288-93. PMID 11296257 DOI: 10.1073/Pnas.081089198 |
0.748 |
|
| 2001 |
Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, ... ... Lester HA, et al. Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proceedings of the National Academy of Sciences of the United States of America. 98: 2786-91. PMID 11226318 DOI: 10.1073/Pnas.041582598 |
0.775 |
|
| 2001 |
Li L, Zhong W, Zacharias N, Gibbs C, Lester HA, Dougherty DA. The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor. Chemistry & Biology. 8: 47-58. PMID 11182318 DOI: 10.1016/S1074-5521(00)00055-7 |
0.431 |
|
| 2001 |
Tong Y, Brandt GS, Li M, Shapovalov G, Slimko E, Karschin A, Dougherty DA, Lester HA. Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel. The Journal of General Physiology. 117: 103-18. PMID 11158164 DOI: 10.1085/Jgp.117.2.103 |
0.354 |
|
| 2000 |
Ehrengruber MU, Muhlebach SG, Söhrman S, Leutenegger CM, Lester HA, Davidson N. Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus. Gene. 258: 63-9. PMID 11111043 DOI: 10.1016/S0378-1119(00)00445-5 |
0.571 |
|
| 2000 |
Nadeau H, McKinney S, Anderson DJ, Lester HA. ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. Journal of Neurophysiology. 84: 1062-75. PMID 10938328 DOI: 10.1152/JN.2000.84.2.1062 |
0.492 |
|
| 2000 |
Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA. State-dependent cross-inhibition between transmitter-gated cation channels. Nature. 406: 405-10. PMID 10935636 DOI: 10.1038/35019066 |
0.643 |
|
| 2000 |
Kofuji P, Ceelen P, Zahs KR, Surbeck LW, Lester HA, Newman EA. Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5733-40. PMID 10908613 DOI: 10.1523/Jneurosci.20-15-05733.2000 |
0.644 |
|
| 2000 |
Lester HA, Karschin A. Gain of function mutants: ion channels and G protein-coupled receptors. Annual Review of Neuroscience. 23: 89-125. PMID 10845060 DOI: 10.1146/annurev.neuro.23.1.89 |
0.383 |
|
| 2000 |
Ivanina T, Neusch C, Li YX, Tong Y, Labarca C, Mosher DF, Lester HA. Expression of GIRK (Kir3.1/Kir3.4) channels in mouse fibroblast cells with and without beta1 integrins. Febs Letters. 466: 327-32. PMID 10682853 DOI: 10.1016/S0014-5793(99)01738-X |
0.352 |
|
| 2000 |
Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA. Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. The Journal of Biological Chemistry. 275: 3397-402. PMID 10652332 DOI: 10.1074/Jbc.275.5.3397 |
0.377 |
|
| 1999 |
England PM, Lester HA, Dougherty DA. Mapping disulfide connectivity using backbone ester hydrolysis. Biochemistry. 38: 14409-15. PMID 10572015 DOI: 10.1021/Bi991424C |
0.348 |
|
| 1999 |
Khakh BS, Lester HA. Dynamic selectivity filters in ion channels. Neuron. 23: 653-8. PMID 10482233 DOI: 10.1016/S0896-6273(01)80025-8 |
0.576 |
|
| 1999 |
Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. Allosteric control of gating and kinetics at P2X(4) receptor channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7289-99. PMID 10460235 |
0.619 |
|
| 1999 |
Khakh BS, Bao XR, Labarca C, Lester HA. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nature Neuroscience. 2: 322-30. PMID 10204538 DOI: 10.1038/7233 |
0.63 |
|
| 1999 |
England PM, Zhang Y, Dougherty DA, Lester HA. Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating. Cell. 96: 89-98. PMID 9989500 DOI: 10.1016/S0092-8674(00)80962-9 |
0.365 |
|
| 1999 |
Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. Allosteric Control of Gating and Kinetics at P2X4Receptor Channels The Journal of Neuroscience. 19: 7289-7299. DOI: 10.1523/Jneurosci.19-17-07289.1999 |
0.654 |
|
| 1998 |
Dougherty DA, Lester HA. The Crystal Structure of a Potassium Channel- A New Era in the Chemistry of Biological Signaling. Angewandte Chemie (International Ed. in English). 37: 2329-2331. PMID 29710958 DOI: 10.1002/(Sici)1521-3773(19980918)37:17<2329::Aid-Anie2329>3.0.Co;2-M |
0.312 |
|
| 1998 |
McPhee JC, Dang YL, Davidson N, Lester HA. Evidence for a functional interaction between integrins and G protein-activated inward rectifier K+ channels. The Journal of Biological Chemistry. 273: 34696-702. PMID 9856991 DOI: 10.1074/jbc.273.52.34696 |
0.635 |
|
| 1998 |
Li YX, Zhang Y, Lester HA, Schuman EM, Davidson N. Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10231-40. PMID 9852560 DOI: 10.1523/Jneurosci.18-24-10231.1998 |
0.685 |
|
| 1998 |
Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA. From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proceedings of the National Academy of Sciences of the United States of America. 95: 12088-93. PMID 9770444 DOI: 10.1073/Pnas.95.21.12088 |
0.406 |
|
| 1998 |
Cao Y, Li M, Mager S, Lester HA. Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7739-49. PMID 9742144 DOI: 10.1523/Jneurosci.18-19-07739.1998 |
0.315 |
|
| 1998 |
Silverman SK, Lester HA, Dougherty DA. Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel. Biophysical Journal. 75: 1330-9. PMID 9726934 DOI: 10.1016/S0006-3495(98)74051-2 |
0.35 |
|
| 1998 |
Li YX, Xu Y, Ju D, Lester HA, Davidson N, Schuman EM. Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 10884-9. PMID 9724799 DOI: 10.1073/pnas.95.18.10884 |
0.692 |
|
| 1998 |
Nowak MW, Gallivan JP, Silverman SK, Labarca CG, Dougherty DA, Lester HA. In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system. Methods in Enzymology. 293: 504-29. PMID 9711626 DOI: 10.1016/S0076-6879(98)93031-2 |
0.342 |
|
| 1998 |
Ehrengruber MU, Lanzrein M, Xu Y, Jasek MC, Kantor DB, Schuman EM, Lester HA, Davidson N. Recombinant adenovirus-mediated expression in nervous system of genes coding for ion channels and other molecules involved in synaptic function. Methods in Enzymology. 293: 483-503. PMID 9711625 DOI: 10.1016/S0076-6879(98)93030-0 |
0.702 |
|
| 1998 |
Yu N, Cao Y, Mager S, Lester HA. Topological localization of cysteine 74 in the GABA transporter, GAT1, and its importance in ion binding and permeation. Febs Letters. 426: 174-8. PMID 9599002 DOI: 10.1016/S0014-5793(98)00333-0 |
0.309 |
|
| 1998 |
Miller JC, Silverman SK, England PM, Dougherty DA, Lester HA. Flash decaging of tyrosine sidechains in an ion channel. Neuron. 20: 619-24. PMID 9581754 DOI: 10.1016/S0896-6273(00)81001-6 |
0.422 |
|
| 1997 |
Luchian T, Dascal N, Dessauer C, Platzer D, Davidson N, Lester HA, Schreibmayer W. A C-terminal peptide of the GIRK1 subunit directly blocks the G protein-activated K+ channel (GIRK) expressed in Xenopus oocytes. The Journal of Physiology. 505: 13-22. PMID 9409468 DOI: 10.1111/J.1469-7793.1997.013Bc.X |
0.724 |
|
| 1997 |
England PM, Lester HA, Davidson N, Dougherty DA. Site-specific, photochemical proteolysis applied to ion channels in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 11025-30. PMID 9380753 DOI: 10.1073/Pnas.94.20.11025 |
0.653 |
|
| 1997 |
Gallivan JP, Lester HA, Dougherty DA. Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins. Chemistry & Biology. 4: 739-49. PMID 9375252 DOI: 10.1016/S1074-5521(97)90312-4 |
0.379 |
|
| 1997 |
West AP, Bjorkman PJ, Dougherty DA, Lester HA. Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 272: 25468-73. PMID 9325259 DOI: 10.1074/Jbc.272.41.25468 |
0.397 |
|
| 1997 |
Doupnik CA, Davidson N, Lester HA, Kofuji P. RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 94: 10461-6. PMID 9294233 DOI: 10.1073/Pnas.94.19.10461 |
0.777 |
|
| 1997 |
Li J, Zagotta WN, Lester HA. Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Quarterly Reviews of Biophysics. 30: 177-93. PMID 9293605 DOI: 10.1017/S0033583597003326 |
0.359 |
|
| 1997 |
Ehrengruber MU, Doupnik CA, Xu Y, Garvey J, Jasek MC, Lester HA, Davidson N. Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 94: 7070-5. PMID 9192693 DOI: 10.1073/Pnas.94.13.7070 |
0.644 |
|
| 1997 |
Quick MW, Corey JL, Davidson N, Lester HA. Second messengers, trafficking-related proteins, and amino acid residues that contribute to the functional regulation of the rat brain GABA transporter GAT1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2967-79. PMID 9096133 DOI: 10.1523/Jneurosci.17-09-02967.1997 |
0.727 |
|
| 1997 |
Bradley J, Zhang Y, Bakin R, Lester HA, Ronnett GV, Zinn K. Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1993-2005. PMID 9045728 DOI: 10.1523/Jneurosci.17-06-01993.1997 |
0.369 |
|
| 1997 |
Zheng C, Dietz G, Hofer M, Millonig J, Millen K, Kofuji P, Davidson N, Lester H, Hatten ME. MECHANISMS OF NEURONAL MIGRATION Journal of Clinical Neurophysiology. 14: 155. DOI: 10.1097/00004691-199703000-00011 |
0.704 |
|
| 1996 |
Silverman SK, Kofuji P, Dougherty DA, Davidson N, Lester HA. A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. Proceedings of the National Academy of Sciences of the United States of America. 93: 15429-34. PMID 8986828 DOI: 10.1073/Pnas.93.26.15429 |
0.756 |
|
| 1996 |
Kearney PC, Zhang H, Zhong W, Dougherty DA, Lester HA. Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position. Neuron. 17: 1221-9. PMID 8982168 DOI: 10.1016/S0896-6273(00)80252-4 |
0.386 |
|
| 1996 |
Lin F, Lester HA, Mager S. Single-channel currents produced by the serotonin transporter and analysis of a mutation affecting ion permeation. Biophysical Journal. 71: 3126-35. PMID 8968583 DOI: 10.1016/S0006-3495(96)79506-1 |
0.351 |
|
| 1996 |
Quick MW, Lester HA, Davidson N, Simon MI, Aragay AM. Desensitization of inositol 1,4,5-trisphosphate/Ca2+-induced Cl- currents by prolonged activation of G proteins in Xenopus oocytes. The Journal of Biological Chemistry. 271: 32021-7. PMID 8943251 DOI: 10.1074/Jbc.271.50.32021 |
0.768 |
|
| 1996 |
Silverman SK, Lester HA, Dougherty DA. Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel. The Journal of Biological Chemistry. 271: 30524-8. PMID 8940021 DOI: 10.1074/Jbc.271.48.30524 |
0.365 |
|
| 1996 |
Doupnik CA, Dessauer CW, Slepak VZ, Gilman AG, Davidson N, Lester HA. Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits. Neuropharmacology. 35: 923-31. PMID 8938723 DOI: 10.1016/0028-3908(96)00125-6 |
0.615 |
|
| 1996 |
Figl A, Labarca C, Davidson N, Lester HA, Cohen BN. Voltage-jump relaxation kinetics for wild-type and chimeric beta subunits of neuronal nicotinic receptors. The Journal of General Physiology. 107: 369-79. PMID 8868048 DOI: 10.1085/jgp.107.3.369 |
0.63 |
|
| 1996 |
Saks ME, Sampson JR, Nowak MW, Kearney PC, Du F, Abelson JN, Lester HA, Dougherty DA. An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression. The Journal of Biological Chemistry. 271: 23169-75. PMID 8798511 DOI: 10.1074/Jbc.271.38.23169 |
0.3 |
|
| 1996 |
Mager S, Kleinberger-Doron N, Keshet GI, Davidson N, Kanner BI, Lester HA. Ion binding and permeation at the GABA transporter GAT1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5405-14. PMID 8757253 DOI: 10.1523/Jneurosci.16-17-05405.1996 |
0.58 |
|
| 1996 |
Kofuji P, Doupnik CA, Davidson N, Lester HA. A unique P-region residue is required for slow voltage-dependent gating of a G protein-activated inward rectifier K+ channel expressed in Xenopus oocytes. The Journal of Physiology. 490: 633-45. PMID 8683463 DOI: 10.1113/Jphysiol.1996.Sp021173 |
0.75 |
|
| 1996 |
Kofuji P, Hofer M, Millen KJ, Millonig JH, Davidson N, Lester HA, Hatten ME. Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells. Neuron. 16: 941-52. PMID 8630252 DOI: 10.1016/S0896-6273(00)80117-8 |
0.754 |
|
| 1996 |
Schreibmayer W, Dessauer CW, Vorobiov D, Gilman AG, Lester HA, Davidson N, Dascal N. Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits. Nature. 380: 624-7. PMID 8602262 DOI: 10.1038/380624A0 |
0.695 |
|
| 1996 |
DiMagno L, Dascal N, Davidson N, Lester HA, Schreibmayer W. Serotonin and protein kinase C modulation of a rat brain inwardly rectifying K+ channel expressed in xenopus oocytes. PflüGers Archiv : European Journal of Physiology. 431: 335-40. PMID 8584426 DOI: 10.1007/Bf02207270 |
0.724 |
|
| 1996 |
Schreibmayer W, Dessauer CW, Vorobiov D, Gilman AG, Lester HA, Davidson N, Dascal N. Correction: Inhibition of an inwardly rectifying K+ channel by G-protein α-subunits Nature. 383: 103-103. DOI: 10.1038/383103C0 |
0.703 |
|
| 1995 |
Bausch SB, Patterson TA, Ehrengruber MU, Lester HA, Davidson N, Chavkin C. Colocalization of mu opioid receptors with GIRK1 potassium channels in the rat brain: an immunocytochemical study. Receptors & Channels. 3: 221-41. PMID 8821795 |
0.538 |
|
| 1995 |
Lim NF, Dascal N, Labarca C, Davidson N, Lester HA. A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes. The Journal of General Physiology. 105: 421-39. PMID 7769382 DOI: 10.1085/Jgp.105.3.421 |
0.724 |
|
| 1995 |
Henry DJ, Grandy DK, Lester HA, Davidson N, Chavkin C. Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. Molecular Pharmacology. 47: 551-7. PMID 7700253 |
0.564 |
|
| 1995 |
Labarca C, Nowak MW, Zhang H, Tang L, Deshpande P, Lester HA. Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature. 376: 514-6. PMID 7637783 DOI: 10.1038/376514a0 |
0.423 |
|
| 1995 |
Kofuji P, Davidson N, Lester HA. Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Proceedings of the National Academy of Sciences of the United States of America. 92: 6542-6. PMID 7604029 DOI: 10.1073/pnas.92.14.6542 |
0.757 |
|
| 1995 |
Doupnik CA, Davidson N, Lester HA. The inward rectifier potassium channel family. Current Opinion in Neurobiology. 5: 268-77. PMID 7580148 DOI: 10.1016/0959-4388(95)80038-7 |
0.616 |
|
| 1995 |
Cohen BN, Figl A, Quick MW, Labarca C, Davidson N, Lester HA. Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors. The Journal of General Physiology. 105: 745-64. PMID 7561742 DOI: 10.1085/jgp.105.6.745 |
0.716 |
|
| 1995 |
Dascal N, Doupnik CA, Ivanina T, Bausch S, Wang W, Lin C, Garvey J, Chavkin C, Lester HA, Davidson N. Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail. Proceedings of the National Academy of Sciences of the United States of America. 92: 6758-62. PMID 7542774 DOI: 10.1073/Pnas.92.15.6758 |
0.727 |
|
| 1995 |
Doupnik CA, Lim NF, Kofuji P, Davidson N, Lester HA. Intrinsic gating properties of a cloned G protein-activated inward rectifier K+ channel. The Journal of General Physiology. 106: 1-23. PMID 7494135 DOI: 10.1085/Jgp.106.1.1 |
0.752 |
|
| 1994 |
Corey JL, Quick MW, Davidson N, Lester HA, Guastella J. A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proceedings of the National Academy of Sciences of the United States of America. 91: 1188-92. PMID 8302852 DOI: 10.1073/Pnas.91.3.1188 |
0.72 |
|
| 1994 |
Corey JL, Davidson N, Lester HA, Brecha N, Quick MW. Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. The Journal of Biological Chemistry. 269: 14759-67. PMID 8182081 |
0.717 |
|
| 1994 |
Mager S, Min C, Henry DJ, Chavkin C, Hoffman BJ, Davidson N, Lester HA. Conducting states of a mammalian serotonin transporter. Neuron. 12: 845-59. PMID 8161456 DOI: 10.1016/0896-6273(94)90337-9 |
0.576 |
|
| 1994 |
Karschin C, Schreibmayer W, Dascal N, Lester H, Davidson N, Karschin A. Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat. Febs Letters. 348: 139-44. PMID 8034029 DOI: 10.1016/0014-5793(94)00590-7 |
0.72 |
|
| 1994 |
Corey JL, Guastella J, Davidson N, Lester HA. GABA uptake and release by a mammalian cell line stably expressing a cloned rat brain GABA transporter. Molecular Membrane Biology. 11: 23-30. PMID 8019597 DOI: 10.3109/09687689409161026 |
0.588 |
|
| 1994 |
Quick MW, Simon MI, Davidson N, Lester HA, Aragay AM. Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes. The Journal of Biological Chemistry. 269: 30164-72. PMID 7982922 |
0.746 |
|
| 1994 |
Lester HA, Mager S, Quick MW, Corey JL. Permeation properties of neurotransmitter transporters. Annual Review of Pharmacology and Toxicology. 34: 219-49. PMID 7913802 DOI: 10.1146/annurev.pa.34.040194.001251 |
0.61 |
|
| 1994 |
Karschin A, Wischmeyer E, Davidson N, Lester HA. Fast inhibition of inwardly rectifying K+ channels by multiple neurotransmitter receptors in oligodendroglia. The European Journal of Neuroscience. 6: 1756-64. PMID 7874315 DOI: 10.1111/j.1460-9568.1994.tb00568.x |
0.647 |
|
| 1994 |
Schreibmayer W, Frohnwieser B, Dascal N, Platzer D, Spreitzer B, Zechner R, Kallen RG, Lester HA. Beta-adrenergic modulation of currents produced by rat cardiac Na+ channels expressed in Xenopus laevis oocytes. Receptors & Channels. 2: 339-50. PMID 7536612 |
0.585 |
|
| 1994 |
McDonough S, Davidson N, Lester HA, McCarty NA. Novel pore-lining residues in CFTR that govern permeation and open-channel block. Neuron. 13: 623-34. PMID 7522483 DOI: 10.1016/0896-6273(94)90030-2 |
0.619 |
|
| 1994 |
Bradley J, Li J, Davidson N, Lester HA, Zinn K. Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proceedings of the National Academy of Sciences of the United States of America. 91: 8890-4. PMID 7522325 DOI: 10.1073/Pnas.91.19.8890 |
0.629 |
|
| 1994 |
Schreibmayer W, Lester HA, Dascal N. Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflã¼Gers Archiv : European Journal of Physiology. 426: 453-8. PMID 7517034 DOI: 10.1007/Bf00388310 |
0.557 |
|
| 1994 |
Quick MW, Lester HA. Methods for Expression of Excitability Proteins in Xenopus Oocytes Methods in Neurosciences. 19: 261-279. DOI: 10.1016/B978-0-12-185287-0.50020-X |
0.643 |
|
| 1993 |
Slepak VZ, Quick MW, Aragay AM, Davidson N, Lester HA, Simon MI. Random mutagenesis of G protein alpha subunit G(o)alpha. Mutations altering nucleotide binding. The Journal of Biological Chemistry. 268: 21889-94. PMID 8408043 |
0.721 |
|
| 1993 |
McCarty NA, McDonough S, Cohen BN, Riordan JR, Davidson N, Lester HA. Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. The Journal of General Physiology. 102: 1-23. PMID 8397274 DOI: 10.1085/Jgp.102.1.1 |
0.629 |
|
| 1993 |
Lester HA, Dascal N. Potassium channels. The response to vagusstoff. Nature. 364: 758-9. PMID 8355802 DOI: 10.1038/364758A0 |
0.526 |
|
| 1993 |
Dascal N, Lim NF, Schreibmayer W, Wang W, Davidson N, Lester HA. Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 90: 6596-600. PMID 8341673 DOI: 10.1073/Pnas.90.14.6596 |
0.737 |
|
| 1993 |
Hsu H, Huang E, Yang XC, Karschin A, Labarca C, Figl A, Ho B, Davidson N, Lester HA. Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons. Biophysical Journal. 65: 1196-206. PMID 8241400 DOI: 10.1016/S0006-3495(93)81153-6 |
0.631 |
|
| 1993 |
Mager S, Naeve J, Quick M, Labarca C, Davidson N, Lester HA. Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron. 10: 177-88. PMID 7679914 DOI: 10.1016/0896-6273(93)90309-F |
0.723 |
|
| 1993 |
Uezono Y, Bradley J, Min C, McCarty NA, Quick M, Riordan JR, Chavkin C, Zinn K, Lester HA, Davidson N. Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors & Channels. 1: 233-41. PMID 7522902 |
0.744 |
|
| 1992 |
Cohen BN, Labarca C, Czyzyk L, Davidson N, Lester HA. Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region. The Journal of General Physiology. 99: 545-72. PMID 1597678 DOI: 10.1085/Jgp.99.4.545 |
0.657 |
|
| 1992 |
Ho BY, Karschin A, Raymond JR, Branchek T, Lester HA, Davidson N. Expression in animal cells of the 5-HT1A receptor by a vaccinia virus vector system. Febs Letters. 301: 303-6. PMID 1533596 DOI: 10.1016/0014-5793(92)80262-F |
0.609 |
|
| 1992 |
Figl A, Cohen BN, Quick MW, Davidson N, Lester HA. Regions of beta 4.beta 2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors. Febs Letters. 308: 245-8. PMID 1505662 DOI: 10.1016/0014-5793(92)81284-S |
0.727 |
|
| 1992 |
Cohen BN, Labarca C, Davidson N, Lester HA. Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations. The Journal of General Physiology. 100: 373-400. PMID 1431803 DOI: 10.1085/Jgp.100.3.373 |
0.641 |
|
| 1992 |
Ho BY, Karschin A, Branchek T, Davidson N, Lester HA. The role of conserved aspartate and serine residues in ligand binding and in function of the 5-HT1A receptor: a site-directed mutation study. Febs Letters. 312: 259-62. PMID 1426261 DOI: 10.1016/0014-5793(92)80948-G |
0.615 |
|
| 1992 |
Karschin A, Thorne BA, Thomas G, Lester HA. Vaccinia virus as vector to express ion channel genes. Methods in Enzymology. 207: 408-23. PMID 1382194 DOI: 10.1016/0076-6879(92)07029-N |
0.34 |
|
| 1992 |
Dascal N, Chilcott G, Lester HA. Intracellular perfusion of Xenopus oocytes. Methods in Enzymology. 207: 345-52. PMID 1382190 DOI: 10.1016/0076-6879(92)07023-H |
0.566 |
|
| 1992 |
Krafte DS, Lester HA. Use of stage II-III Xenopus oocytes to study voltage-dependent ion channels. Methods in Enzymology. 207: 339-45. PMID 1382189 DOI: 10.1016/0076-6879(92)07022-G |
0.317 |
|
| 1992 |
Lester HA. The permeation pathway of neurotransmitter-gated ion channels. Annual Review of Biophysics and Biomolecular Structure. 21: 267-92. PMID 1381975 DOI: 10.1146/annurev.bb.21.060192.001411 |
0.307 |
|
| 1992 |
Charnet P, Labarca C, Lester HA. Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission. Molecular Pharmacology. 41: 708-17. PMID 1373800 |
0.626 |
|
| 1992 |
Charnet P, Labarca C, Cohen BN, Davidson N, Lester HA, Pilar G. Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. The Journal of Physiology. 450: 375-94. PMID 1359123 DOI: 10.1113/Jphysiol.1992.Sp019132 |
0.771 |
|
| 1992 |
Quick MW, Naeve J, Davidson N, Lester HA. Incubation with horse serum increases viability and decreases background neurotransmitter uptake in Xenopus oocytes. Biotechniques. 13: 357-61. PMID 1356369 |
0.687 |
|
| 1992 |
Guastella J, Brecha N, Weigmann C, Lester HA, Davidson N. Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proceedings of the National Academy of Sciences of the United States of America. 89: 7189-93. PMID 1353889 DOI: 10.1073/Pnas.89.15.7189 |
0.596 |
|
| 1992 |
Nargeot J, Dascal N, Lester HA. Heterologous expression of calcium channels. The Journal of Membrane Biology. 126: 97-108. PMID 1317459 DOI: 10.1007/Bf00231908 |
0.677 |
|
| 1992 |
Yang XC, Labarca C, Nargeot J, Ho BY, Elroy-Stein O, Moss B, Davidson N, Lester HA. Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 268-77. PMID 1309573 DOI: 10.1523/Jneurosci.12-01-00268.1992 |
0.728 |
|
| 1991 |
Leonard RJ, Charnet P, Labarca C, Vogelaar NJ, Czyzyk L, Gouin A, Davidson N, Lester HA. Reverse pharmacology of the nicotinic acetylcholine receptor. Mapping the local anesthetic binding site. Annals of the New York Academy of Sciences. 625: 588-99. PMID 2058913 DOI: 10.1111/j.1749-6632.1991.tb33894.x |
0.759 |
|
| 1991 |
Walter AE, Hoger JH, Labarca C, Yu L, Davidson N, Lester HA. Low molecular weight mRNA encodes a protein that controls serotonin 5-HT1c and acetylcholine M1 receptor sensitivity in Xenopus oocytes. The Journal of General Physiology. 98: 399-417. PMID 1940855 DOI: 10.1085/Jgp.98.2.399 |
0.622 |
|
| 1991 |
Karschin A, Ho BY, Labarca C, Elroy-Stein O, Moss B, Davidson N, Lester HA. Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart. Proceedings of the National Academy of Sciences of the United States of America. 88: 5694-8. PMID 1905814 DOI: 10.1073/pnas.88.13.5694 |
0.654 |
|
| 1991 |
Hoger JH, Walter AE, Vance D, Yu L, Lester HA, Davidson N. Modulation of a cloned mouse brain potassium channel. Neuron. 6: 227-36. PMID 1899581 DOI: 10.1016/0896-6273(91)90358-7 |
0.633 |
|
| 1991 |
Karschin A, Aiyar J, Gouin A, Davidson N, Lester HA. K+ channel expression in primary cell cultures mediated by vaccinia virus. Febs Letters. 278: 229-33. PMID 1899389 DOI: 10.1016/0014-5793(91)80123-K |
0.624 |
|
| 1991 |
Leonard RJ, Charnet P, Labarca C, Vogelaar NJ, Czyzyk L, Gouin A, Davidson N, Lester HA. Mutations affecting local anesthetic block of the nicotinic acetylcholine receptor ion channel. Nida Research Monograph. 111: 28-44. PMID 1723151 |
0.75 |
|
| 1991 |
Dascal N, Chilcott G, Lester HA. Recording of voltage and Ca(2+)-dependent currents in Xenopus oocytes using an intracellular perfusion method. Journal of Neuroscience Methods. 39: 29-38. PMID 1722267 DOI: 10.1016/0165-0270(91)90090-M |
0.593 |
|
| 1991 |
Yu L, Leonard RJ, Davidson N, Lester HA. Single-channel properties of mouse-Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes. Brain Research. Molecular Brain Research. 10: 203-11. PMID 1715966 DOI: 10.1016/0169-328X(91)90062-3 |
0.663 |
|
| 1991 |
Lester HA. Strategies for studying permeation at voltage-gated ion channels. Annual Review of Physiology. 53: 477-96. PMID 1710440 DOI: 10.1146/annurev.ph.53.030191.002401 |
0.321 |
|
| 1991 |
Yang XC, Karschin A, Labarca C, Elroy-Stein O, Moss B, Davidson N, Lester HA. Expression of ion channels and receptors in Xenopus oocytes using vaccinia virus. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2209-16. PMID 1708738 DOI: 10.1096/fasebj.5.8.1708738 |
0.654 |
|
| 1991 |
Yu L, Nguyen H, Le H, Bloem LJ, Kozak CA, Hoffman BJ, Snutch TP, Lester HA, Davidson N, Lübbert H. The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked. Brain Research. Molecular Brain Research. 11: 143-9. PMID 1661811 DOI: 10.1016/0169-328X(91)90116-F |
0.718 |
|
| 1991 |
Hoger JH, Rudy B, Lester HA, Davidson N. Characterization of maintained voltage-dependent K(+)-channels induced in Xenopus oocytes by rat brain mRNA. Brain Research. Molecular Brain Research. 10: 1-11. PMID 1647478 DOI: 10.1016/0169-328X(91)90050-8 |
0.608 |
|
| 1990 |
Ahmed CM, Auld VJ, Lester HA, Dunn R, Davidson N. Both sodium channel II and IIA alpha subunits are expressed in rat brain. Nucleic Acids Research. 18: 5907. PMID 2170951 DOI: 10.1093/Nar/18.19.5907 |
0.61 |
|
| 1990 |
Guastella J, Nelson N, Nelson H, Czyzyk L, Keynan S, Miedel MC, Davidson N, Lester HA, Kanner BI. Cloning and expression of a rat brain GABA transporter. Science (New York, N.Y.). 249: 1303-6. PMID 1975955 DOI: 10.1126/Science.1975955 |
0.585 |
|
| 1990 |
Krafte DS, Goldin AL, Auld VJ, Dunn RJ, Davidson N, Lester HA. Inactivation of cloned Na channels expressed in Xenopus oocytes. The Journal of General Physiology. 96: 689-706. PMID 1701828 DOI: 10.1085/Jgp.96.4.689 |
0.738 |
|
| 1990 |
Snutch TP, Leonard JP, Gilbert MM, Lester HA, Davidson N. Rat brain expresses a heterogeneous family of calcium channels. Proceedings of the National Academy of Sciences of the United States of America. 87: 3391-5. PMID 1692134 DOI: 10.1073/Pnas.87.9.3391 |
0.701 |
|
| 1990 |
Charnet P, Labarca C, Leonard RJ, Vogelaar NJ, Czyzyk L, Gouin A, Davidson N, Lester HA. An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor. Neuron. 4: 87-95. PMID 1690017 DOI: 10.1016/0896-6273(90)90445-L |
0.764 |
|
| 1990 |
Auld VJ, Goldin AL, Krafte DS, Catterall WA, Lester HA, Davidson N, Dunn RJ. A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 87: 323-7. PMID 1688658 DOI: 10.1073/Pnas.87.1.323 |
0.721 |
|
| 1990 |
Guastella J, Nelson N, Nelson H, Czyzyk L, Keynan S, Miedel M, Davidson N, Lester H, Kanner B. Cloning and expression of a rat brain GABA transporter Science. 249: 1303-1306. DOI: 10.1126/science.1975955 |
0.522 |
|
| 1989 |
Yu L, Blumer KJ, Davidson N, Lester HA, Thorner J. Functional expression of the yeast alpha-factor receptor in Xenopus oocytes. The Journal of Biological Chemistry. 264: 20847-50. PMID 2556384 |
0.608 |
|
| 1989 |
Krafte DS, Lester HA. Expression of functional sodium channels in stage II-III Xenopus oocytes. Journal of Neuroscience Methods. 26: 211-5. PMID 2537447 DOI: 10.1016/0165-0270(89)90118-0 |
0.33 |
|
| 1989 |
Leonard RJ, Karschin A, Jayashree-Aiyar S, Davidson N, Tanouye MA, Thomas L, Thomas G, Lester HA. Expression of Drosophila Shaker potassium channels in mammalian cells infected with recombinant vaccinia virus. Proceedings of the National Academy of Sciences of the United States of America. 86: 7629-33. PMID 2477844 DOI: 10.1073/Pnas.86.19.7629 |
0.605 |
|
| 1989 |
Fong TM, Davidson N, Lester HA. Further evidence demonstrating that N-methyl-D-aspartate and kainate activate distinct ion channels. Synapse (New York, N.Y.). 4: 88-95. PMID 2475918 DOI: 10.1002/syn.890040110 |
0.619 |
|
| 1989 |
Lester HA, Snutch TP, Leonard JP, Nargeot J, Dascal N, Curtis BM, Davidson N. Expression of mRNA encoding voltage-dependent Ca channels in Xenopus oocytes. Review and progress report. Annals of the New York Academy of Sciences. 560: 174-82. PMID 2472764 DOI: 10.1111/J.1749-6632.1989.Tb24094.X |
0.789 |
|
| 1988 |
Rudy B, Hoger JH, Lester HA, Davidson N. At least two mRNA species contribute to the properties of rat brain A-type potassium channels expressed in Xenopus oocytes. Neuron. 1: 649-58. PMID 3272183 DOI: 10.1016/0896-6273(88)90164-X |
0.616 |
|
| 1988 |
Fong TM, Davidson N, Lester HA. Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes. Synapse (New York, N.Y.). 2: 657-65. PMID 2905539 DOI: 10.1002/syn.890020613 |
0.626 |
|
| 1988 |
Auld VJ, Goldin AL, Krafte DS, Marshall J, Dunn JM, Catterall WA, Lester HA, Davidson N, Dunn RJ. A rat brain Na+ channel alpha subunit with novel gating properties. Neuron. 1: 449-61. PMID 2856097 DOI: 10.1016/0896-6273(88)90176-6 |
0.743 |
|
| 1988 |
Leonard RJ, Labarca CG, Charnet P, Davidson N, Lester HA. Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science (New York, N.Y.). 242: 1578-81. PMID 2462281 DOI: 10.1126/Science.2462281 |
0.778 |
|
| 1988 |
Lester HA. Heterologous expression of excitability proteins: route to more specific drugs? Science (New York, N.Y.). 241: 1057-63. PMID 2457947 DOI: 10.1126/Science.2457947 |
0.359 |
|
| 1988 |
Krafte DS, Snutch TP, Leonard JP, Davidson N, Lester HA. Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2859-68. PMID 2457660 DOI: 10.1523/Jneurosci.08-08-02859.1988 |
0.715 |
|
| 1988 |
Iverson LE, Tanouye MA, Lester HA, Davidson N, Rudy B. A-type potassium channels expressed from Shaker locus cDNA. Proceedings of the National Academy of Sciences of the United States of America. 85: 5723-7. PMID 2456579 DOI: 10.1073/Pnas.85.15.5723 |
0.622 |
|
| 1988 |
Sutton F, Davidson N, Lester HA. Tetrodotoxin-sensitive voltage-dependent Na currents recorded from Xenopus oocytes injected with mammalian cardiac muscle RNA. Brain Research. 427: 187-91. PMID 2454698 DOI: 10.1016/0169-328X(88)90065-4 |
0.594 |
|
| 1987 |
Yoshii K, Yu L, Mayne KM, Davidson N, Lester HA. Equilibrium properties of mouse-Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes. The Journal of General Physiology. 90: 553-73. PMID 3681261 DOI: 10.1085/Jgp.90.4.553 |
0.652 |
|
| 1987 |
Mayne KM, Yoshii K, Yu L, Lester HA, Davidson N. Expression of mouse-Torpedo acetylcholine receptor subunit chimeras and hybrids in Xenopus oocytes. Brain Research. 388: 191-7. PMID 3676709 DOI: 10.1016/0169-328X(87)90026-X |
0.663 |
|
| 1987 |
Lübbert H, Hoffman BJ, Snutch TP, van Dyke T, Levine AJ, Hartig PR, Lester HA, Davidson N. cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 84: 4332-6. PMID 3473504 DOI: 10.1073/Pnas.84.12.4332 |
0.722 |
|
| 1987 |
Lübbert H, Snutch TP, Dascal N, Lester HA, Davidson N. Rat brain 5-HT1C receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 1159-65. PMID 2883267 DOI: 10.1523/Jneurosci.07-04-01159.1987 |
0.766 |
|
| 1987 |
Snutch TP, Leonard JP, Nargeot J, Lübbert H, Davidson N, Lester HA. Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA from electrically excitable tissues. Society of General Physiologists Series. 42: 153-66. PMID 2850608 |
0.733 |
|
| 1987 |
Leonard JP, Nargeot J, Snutch TP, Davidson N, Lester HA. Ca channels induced in Xenopus oocytes by rat brain mRNA. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 875-81. PMID 2435866 DOI: 10.1523/Jneurosci.07-03-00875.1987 |
0.767 |
|
| 1986 |
Dascal N, Ifune C, Hopkins R, Snutch TP, Lübbert H, Davidson N, Simon MI, Lester HA. Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA. Brain Research. 387: 201-9. PMID 2435359 DOI: 10.1016/0169-328X(86)90026-4 |
0.762 |
|
| 1986 |
Goldin AL, Snutch T, Lübbert H, Dowsett A, Marshall J, Auld V, Downey W, Fritz LC, Lester HA, Dunn R. Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 83: 7503-7. PMID 2429308 DOI: 10.1073/Pnas.83.19.7503 |
0.721 |
|
| 1986 |
Chabala LD, Gurney AM, Lester HA. Dose-response of acetylcholine receptor channels opened by a flash-activated agonist in voltage-clamped rat myoballs. The Journal of Physiology. 371: 407-33. PMID 2422352 DOI: 10.1113/jphysiol.1986.sp015983 |
0.375 |
|
| 1986 |
Dascal N, Snutch TP, Lübbert H, Davidson N, Lester HA. Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes. Science (New York, N.Y.). 231: 1147-50. PMID 2418503 DOI: 10.1126/Science.2418503 |
0.758 |
|
| 1985 |
Krouse ME, Lester HA, Wassermann NH, Erlanger BF. Rates and equilibria for a photoisomerizable antagonist at the acetylcholine receptor of Electrophorus electroplaques. The Journal of General Physiology. 86: 235-56. PMID 4045419 DOI: 10.1085/JGP.86.2.235 |
0.364 |
|
| 1985 |
White MM, Mayne KM, Lester HA, Davidson N. Mouse-Torpedo hybrid acetylcholine receptors: functional homology does not equal sequence homology. Proceedings of the National Academy of Sciences of the United States of America. 82: 4852-6. PMID 3860826 DOI: 10.1073/Pnas.82.14.4852 |
0.685 |
|
| 1985 |
Dascal N, Lotan I, Gillo B, Lester HA, Lass Y. Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 82: 6001-5. PMID 2994058 DOI: 10.1073/Pnas.82.17.6001 |
0.583 |
|
| 1985 |
Richard S, Nerbonne JM, Nargeot J, Lester HA, Garnier D. Photochemically produced intracellular concentration jumps of cAMP mimic the effects of catecholamines on excitation-contraction coupling in frog atrial fibers. Pflã¼Gers Archiv : European Journal of Physiology. 403: 312-7. PMID 2986078 DOI: 10.1007/BF00583606 |
0.55 |
|
| 1985 |
Gurney AM, Nerbonne JM, Lester HA. Photoinduced removal of nifedipine reveals mechanisms of calcium antagonist action on single heart cells Journal of General Physiology. 86: 353-379. PMID 2414392 DOI: 10.1085/Jgp.86.3.353 |
0.347 |
|
| 1985 |
Chabala LD, Gurney AM, Lester HA. Photoactivation and dissociation of agonist molecules at the nicotinic acetylcholine receptor in voltage-clamped rat myoballs. Biophysical Journal. 48: 241-6. PMID 2413914 DOI: 10.1016/S0006-3495(85)83777-2 |
0.379 |
|
| 1984 |
Nerbonne JM, Richard S, Nargeot J, Lester HA. New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations. Nature. 310: 74-6. PMID 6330568 DOI: 10.1038/310074a0 |
0.523 |
|
| 1983 |
Nargeot J, Nerbonne JM, Engels J, Lester HA. Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP. Proceedings of the National Academy of Sciences of the United States of America. 80: 2395-9. PMID 6300914 DOI: 10.1073/Pnas.80.8.2395 |
0.561 |
|
| 1983 |
Sheridan RE, Lester HA. Functional stoichiometry at the nicotinic receptor. The photon cross section for phase 1 corresponds to two bis-Q molecules per channel. The Journal of General Physiology. 80: 499-515. PMID 6292333 DOI: 10.1085/JGP.80.4.499 |
0.365 |
|
| 1982 |
Nargeot J, Lester HA, Birdsall NJ, Stockton J, Wassermann NH, Erlanger BF. A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart. The Journal of General Physiology. 79: 657-78. PMID 6978380 DOI: 10.1085/JGP.79.4.657 |
0.568 |
|
| 1980 |
Lester HA, Krouse ME, Nass MM, Wassermann NH, Erlanger BF. A covalently bound photoisomerizable agonist: comparison with reversibly bound agonists at Electrophorus electroplaques. The Journal of General Physiology. 75: 207-232. PMID 6246192 DOI: 10.1085/Jgp.75.2.207 |
0.369 |
|
| 1979 |
Lester HA. Analysis of sodium and potassium redistribution during sustained permeability increases at the innervated face of Electrophorus electroplaques. The Journal of General Physiology. 72: 847-62. PMID 731201 DOI: 10.1085/JGP.72.6.847 |
0.331 |
|
| 1979 |
Nass MM, Lester HA, Krouse ME. Response of acetylcholine receptors to photoisomerizations of bound agonist molecules. Biophysical Journal. 24: 135-60. PMID 708818 DOI: 10.1016/S0006-3495(78)85352-1 |
0.32 |
|
| 1979 |
Lester HA, Krouse ME, Nass MM, Wassermann NH, Erlanger BF. Light-activated drug confirms a mechanism of ion channel blockade. Nature. 280: 509-510. PMID 460432 DOI: 10.1038/280509A0 |
0.384 |
|
| 1978 |
Lester HA, Koblin DD, Sheridan RE. Role of voltage-sensitive receptors in nicotinic transmission. Biophysical Journal. 21: 181-94. PMID 630039 DOI: 10.1016/S0006-3495(78)85518-0 |
0.392 |
|
| 1977 |
Lester HA, Chang HW. Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration. Nature. 266: 373-4. PMID 859605 DOI: 10.1038/266373A0 |
0.384 |
|
| 1977 |
Sheridan RE, Lester HA. Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations The Journal of General Physiology. 70: 187-219. DOI: 10.1085/Jgp.70.2.187 |
0.368 |
|
| 1976 |
Sheridan RE, Lester HA. Relaxation measurements on the acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America. 72: 3496-500. PMID 1059136 DOI: 10.1073/PNAS.72.9.3496 |
0.35 |
|
| 1975 |
Lester HA, Changeux JP, Sheridan RE. Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques. The Journal of General Physiology. 65: 797-816. PMID 1194885 DOI: 10.1085/Jgp.65.6.797 |
0.488 |
|
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