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Juan Valcárcel, PhD - Publications

Affiliations: 
2004- Genome Biology Centre for Genomic Regulation (CRG), Spain 
Area:
Alternative Splicing, RNA
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Guerra-Moreno Á, Valcárcel J. AI-assisted proofreading of RNA splicing. Genes & Development. 37: 945-947. PMID 38092520 DOI: 10.1101/gad.351373.123  0.324
2023 López-Oreja I, Gohr A, Playa-Albinyana H, Giró A, Arenas F, Higashi M, Tripathi R, López-Guerra M, Irimia M, Aymerich M, Valcárcel J, Bonnal S, Colomer D. mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia. Life Science Alliance. 6. PMID 37562845 DOI: 10.26508/lsa.202301955  0.481
2023 Juan-Mateu J, Bajew S, Miret-Cuesta M, Íñiguez LP, Lopez-Pascual A, Bonnal S, Atla G, Bonàs-Guarch S, Ferrer J, Valcárcel J, Irimia M. Pancreatic microexons regulate islet function and glucose homeostasis. Nature Metabolism. PMID 36759540 DOI: 10.1038/s42255-022-00734-2  0.447
2022 Rogalska ME, Vivori C, Valcárcel J. Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects. Nature Reviews. Genetics. 24: 251-269. PMID 36526860 DOI: 10.1038/s41576-022-00556-8  0.311
2020 Baeza-Centurion P, Minana B, Valcarcel J, Lehner B. Mutations primarily alter the inclusion of alternatively spliced exons. Elife. 9. PMID 33112234 DOI: 10.7554/eLife.59959  0.333
2019 Keiper S, Papasaikas P, Will CL, Valcárcel J, Girard C, Lührmann R. Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications. 10: 3639. PMID 31409787 DOI: 10.1038/S41467-019-11293-8  0.305
2019 Torres-Méndez A, Bonnal S, Marquez Y, Roth J, Iglesias M, Permanyer J, Almudí I, O'Hanlon D, Guitart T, Soller M, Gingras AC, Gebauer F, Rentzsch F, Blencowe BJ, Valcárcel J, et al. A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons. Nature Ecology & Evolution. PMID 30833759 DOI: 10.1038/S41559-019-0813-6  0.46
2017 Vigevani L, Gohr A, Webb T, Irimia M, Valcárcel J. Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP. Nature Communications. 8: 2100. PMID 29235465 DOI: 10.1038/S41467-017-02007-Z  0.453
2016 Sebestyén E, Singh B, Miñana B, Pagès A, Mateo F, Pujana MA, Valcárcel J, Eyras E. Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks. Genome Research. PMID 27197215 DOI: 10.1101/gr.199935.115  0.323
2016 Julien P, Miñana B, Baeza-Centurion P, Valcárcel J, Lehner B. The complete local genotype-phenotype landscape for the alternative splicing of a human exon. Nature Communications. 7: 11558. PMID 27161764 DOI: 10.1038/Ncomms11558  0.316
2016 Hernández J, Bechara E, Schlesinger D, Delgado J, Serrano L, Valcárcel J. Tumor suppressor properties of the splicing regulatory factor RBM10. Rna Biology. 0. PMID 26853560 DOI: 10.1080/15476286.2016.1144004  0.33
2014 Alló M, Agirre E, Bessonov S, Bertucci P, Gómez Acuña L, Buggiano V, Bellora N, Singh B, Petrillo E, Blaustein M, Miñana B, Dujardin G, Pozzi B, Pelisch F, Bechara E, et al. Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 15622-9. PMID 25313066 DOI: 10.1073/pnas.1416858111  0.319
2014 Barberán-Soler S, Fontrodona L, Ribó A, Lamm AT, Iannone C, Cerón J, Lehner B, Valcárcel J. Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR. Cell Reports. 8: 1609-16. PMID 25220461 DOI: 10.1016/J.Celrep.2014.08.016  0.358
2013 Iannone C, Valcárcel J. Chromatin's thread to alternative splicing regulation. Chromosoma. 122: 465-74. PMID 23912688 DOI: 10.1007/s00412-013-0425-x  0.31
2013 Blázquez L, Aiastui A, Goicoechea M, Martins de Araujo M, Avril A, Beley C, García L, Valcárcel J, Fortes P, López de Munain A. In vitro correction of a pseudoexon-generating deep intronic mutation in LGMD2A by antisense oligonucleotides and modified small nuclear RNAs. Human Mutation. 34: 1387-95. PMID 23864287 DOI: 10.1002/humu.22379  0.37
2013 Bonnal S, Vigevani L, Valcárcel J. The spliceosome as a target of novel antitumour drugs. Nature Reviews. Drug Discovery. 11: 847-59. PMID 23123942 DOI: 10.1038/nrd3823  0.333
2012 Auboeuf D, Carmo-Fonseca M, Valcarcel J, Biamonti G. Alternative splicing and cancer. Journal of Nucleic Acids. 2012: 363809. PMID 22685632 DOI: 10.1155/2012/363809  0.303
2011 Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcárcel J, Sattler M. Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature. 475: 408-11. PMID 21753750 DOI: 10.1038/Nature10171  0.325
2011 Corrionero A, Miñana B, Valcárcel J. Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes & Development. 25: 445-59. PMID 21363963 DOI: 10.1101/gad.2014311  0.353
2009 Tilgner H, Nikolaou C, Althammer S, Sammeth M, Beato M, Valcárcel J, Guigó R. Nucleosome positioning as a determinant of exon recognition. Nature Structural & Molecular Biology. 16: 996-1001. PMID 19684599 DOI: 10.1038/Nsmb.1658  0.345
2009 Hartmann B, Valcárcel J. Decrypting the genome's alternative messages Current Opinion in Cell Biology. 21: 377-386. PMID 19307111 DOI: 10.1016/j.ceb.2009.02.006  0.322
2009 Martins de Araújo M, Bonnal S, Hastings ML, Krainer AR, Valcárcel J. Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. Rna (New York, N.Y.). 15: 515-23. PMID 19244360 DOI: 10.1261/rna.1273209  0.351
2007 Corsini L, Bonnal S, Bonna S, Basquin J, Hothorn M, Scheffzek K, Valcárcel J, Sattler M. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature Structural & Molecular Biology. 14: 620-9. PMID 17589525 DOI: 10.1038/Nsmb1260  0.334
2006 Soares LM, Zanier K, Mackereth C, Sattler M, Valcárcel J. Intron removal requires proofreading of U2AF/3' splice site recognition by DEK. Science (New York, N.Y.). 312: 1961-5. PMID 16809543 DOI: 10.1126/Science.1128659  0.301
2005 Relógio A, Ben-Dov C, Baum M, Ruggiu M, Gemund C, Benes V, Darnell RB, Valcárcel J. Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells. The Journal of Biological Chemistry. 280: 4779-84. PMID 15546866 DOI: 10.1074/jbc.M411976200  0.306
2004 Pacheco TR, Gomes AQ, Barbosa-Morais NL, Benes V, Ansorge W, Wollerton M, Smith CW, Valcárcel J, Carmo-Fonseca M. Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS. The Journal of Biological Chemistry. 279: 27039-49. PMID 15096518 DOI: 10.1074/Jbc.M402136200  0.337
2004 Banerjee H, Rahn A, Gawande B, Guth S, Valcárcel J, Singh R. The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF65) is essential in vivo but dispensable for activity in vitro Rna. 10: 240-253. PMID 14730023 DOI: 10.1261/Rna.5153204  0.315
2002 Lallena MJ, Chalmers KJ, Llamazares S, Lamond AI, Valcárcel J. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Cell. 109: 285-96. PMID 12015979 DOI: 10.1016/S0092-8674(02)00730-4  0.314
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