| Year |
Citation |
Score |
| 2023 |
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... Troy CM, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w |
0.448 |
|
| 2022 |
Colón Ortiz C, Neal AM, Avrutsky MI, Choi M, Smart J, Lawson J, Troy CM. Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline. Cell Death & Disease. 13: 993. PMID 36424373 DOI: 10.1038/s41419-022-05440-1 |
0.306 |
|
| 2022 |
Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, et al. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death & Disease. 13: 959. PMID 36379916 DOI: 10.1038/s41419-022-05396-2 |
0.603 |
|
| 2022 |
Colón Ortiz C, Neal AM, Avrutsky MI, Choi M, Smart J, Lawson J, Troy CM. Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline. Cell Death & Disease. 13: 937. PMID 36347836 DOI: 10.1038/s41419-022-05387-3 |
0.403 |
|
| 2022 |
Colón Ortiz CK, Potenski AM, Johnson KV, Chen CW, Snipas SJ, Jean YY, Avrutsky MI, Troy CM. Quantification of Immunostained Caspase-9 in Retinal Tissue. Journal of Visualized Experiments : Jove. PMID 35938825 DOI: 10.3791/64237 |
0.437 |
|
| 2021 |
Avrutsky MI, Troy CM. Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease. Frontiers in Pharmacology. 12: 701301. PMID 34305609 DOI: 10.3389/fphar.2021.701301 |
0.443 |
|
| 2020 |
Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM. Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. Nature Communications. 11: 3502. PMID 32647109 DOI: 10.1038/S41467-020-17476-Y |
0.328 |
|
| 2020 |
Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM. Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. Nature Communications. 11: 3173. PMID 32576823 DOI: 10.1038/S41467-020-16902-5 |
0.476 |
|
| 2020 |
Montroull LE, Rothbard DE, Kanal HD, D'Mello V, Dodson V, Troy CM, Zanin JP, Levison SW, Friedman WJ. Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice. Asn Neuro. 12: 1759091420930865. PMID 32493127 DOI: 10.1177/1759091420930865 |
0.456 |
|
| 2016 |
Troy CM, Shelanski ML. Caspase-2 and tau-a toxic partnership? Nature Medicine. 22: 1207-1208. PMID 27824824 DOI: 10.1038/nm.4227 |
0.596 |
|
| 2016 |
Di Donato N, Jean YY, Maga AM, Krewson BD, Shupp AB, Avrutsky MI, Roy A, Collins S, Olds C, Willert RA, Czaja AM, Johnson R, Stover JA, Gottlieb S, Bartholdi D, ... ... Troy CM, et al. Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. American Journal of Human Genetics. PMID 27773430 DOI: 10.1016/J.Ajhg.2016.09.010 |
0.543 |
|
| 2015 |
Jean YY, Baleriola J, Fà M, Hengst U, Troy CM. Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus. Journal of Visualized Experiments : Jove. e52805. PMID 26132278 DOI: 10.3791/52805 |
0.373 |
|
| 2015 |
Troy CM, Jean YY. Caspases: therapeutic targets in neurologic disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 42-8. PMID 25339539 DOI: 10.1007/s13311-014-0307-9 |
0.515 |
|
| 2014 |
Blanch RJ, Ahmed Z, Thompson AR, Akpan N, Snead DR, Berry M, Troy CM, Scott RA, Logan A. Caspase-9 mediates photoreceptor death after blunt ocular trauma. Investigative Ophthalmology & Visual Science. 55: 6350-7. PMID 25190658 DOI: 10.1167/Iovs.13-13708 |
0.786 |
|
| 2014 |
Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U. Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell. 158: 1159-72. PMID 25171414 DOI: 10.1016/J.Cell.2014.07.001 |
0.592 |
|
| 2014 |
Vigneswara V, Akpan N, Berry M, Logan A, Troy CM, Ahmed Z. Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling. Brain : a Journal of Neurology. 137: 1656-75. PMID 24727569 DOI: 10.1093/Brain/Awu037 |
0.759 |
|
| 2013 |
Jean YY, Ribe EM, Pero ME, Moskalenko M, Iqbal Z, Marks LJ, Greene LA, Troy CM. Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. The Biochemical Journal. 455: 15-25. PMID 23815625 DOI: 10.1042/Bj20130556 |
0.57 |
|
| 2013 |
Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O, Shelanski M. Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nature Communications. 4: 1939. PMID 23748737 DOI: 10.1038/Ncomms2927 |
0.762 |
|
| 2013 |
Akpan N, Troy CM. Caspase inhibitors: prospective therapies for stroke. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 19: 129-36. PMID 22645109 DOI: 10.1177/1073858412447875 |
0.79 |
|
| 2013 |
Troy CM, Jean YY. Caspase-2 Handbook of Proteolytic Enzymes. 2: 2243-2247. DOI: 10.1016/B978-0-12-382219-2.00504-4 |
0.404 |
|
| 2012 |
Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L. Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection. Molecular Neurodegeneration. 7: 60. PMID 23217200 DOI: 10.1186/1750-1326-7-60 |
0.777 |
|
| 2012 |
Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM. Neuronal caspase 2 activity and function requires RAIDD, but not PIDD. The Biochemical Journal. 444: 591-9. PMID 22515271 DOI: 10.1042/BJ20111588 |
0.581 |
|
| 2012 |
Sproul AA, Jacob S, Nestor MW, Keilani S, Jean Y, Kahler DJ, Santa-Maria I, Steele J, Crary JF, Troy CM, Gandy S, Noggle SA. S5-01-02: Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts Alzheimer's & Dementia. 8: P724-P724. DOI: 10.1016/J.Jalz.2012.05.1945 |
0.563 |
|
| 2011 |
Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, Salvesen GS, Connolly ES, Troy CM. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8894-904. PMID 21677173 DOI: 10.1523/Jneurosci.0698-11.2011 |
0.812 |
|
| 2011 |
Troy CM, Akpan N, Jean YY. Regulation of caspases in the nervous system implications for functions in health and disease. Progress in Molecular Biology and Translational Science. 99: 265-305. PMID 21238939 DOI: 10.1016/B978-0-12-385504-6.00007-5 |
0.823 |
|
| 2010 |
Tizon B, Ribe EM, Mi W, Troy CM, Levy E. Cystatin C protects neuronal cells from amyloid-beta-induced toxicity. Journal of Alzheimer's Disease : Jad. 19: 885-94. PMID 20157244 DOI: 10.3233/JAD-2010-1291 |
0.404 |
|
| 2010 |
Pozueta J, Ribe E, Arancio O, Troy C, Shelanski M. O4-02-08: Caspase 2 is required for Aβ-induced spine loss Alzheimer's & Dementia. 6: S154-S154. DOI: 10.1016/J.Jalz.2010.05.480 |
0.603 |
|
| 2009 |
Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8828-38. PMID 19587290 DOI: 10.1523/Jneurosci.1779-09.2009 |
0.582 |
|
| 2009 |
Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT. The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1011-6. PMID 19176810 DOI: 10.1523/JNEUROSCI.5175-08.2009 |
0.548 |
|
| 2008 |
Troy CM, Ribe EM. Caspase-2: vestigial remnant or master regulator? Science Signaling. 1: pe42. PMID 18812565 DOI: 10.1126/scisignal.138pe42 |
0.543 |
|
| 2008 |
Ribe EM, Serrano-Saiz E, Akpan N, Troy CM. Mechanisms of neuronal death in disease: defining the models and the players. The Biochemical Journal. 415: 165-82. PMID 18800967 DOI: 10.1042/Bj20081118 |
0.804 |
|
| 2008 |
Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA. β-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation: JNK activation and Aβ-induced death Journal of Neurochemistry. 77: 157-164. DOI: 10.1046/J.1471-4159.2001.00218.X |
0.667 |
|
| 2007 |
Biswas SC, Shi Y, Vonsattel JP, Leung CL, Troy CM, Greene LA. Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 893-900. PMID 17251431 DOI: 10.1523/JNEUROSCI.3524-06.2007 |
0.5 |
|
| 2007 |
Greene LA, Liu DX, Troy CM, Biswas SC. Cell cycle molecules define a pathway required for neuron death in development and disease. Biochimica Et Biophysica Acta. 1772: 392-401. PMID 17229557 DOI: 10.1016/j.bbadis.2006.12.003 |
0.531 |
|
| 2006 |
Wang Q, Maniati M, Jabado O, Pavlaki M, Troy CM, Greene LA, Stefanis L. RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal. Cell Death and Differentiation. 13: 75-83. PMID 15947787 DOI: 10.1038/sj.cdd.4401690 |
0.588 |
|
| 2005 |
Prunell GF, Arboleda VA, Troy CM. Caspase function in neuronal death: delineation of the role of caspases in ischemia. Current Drug Targets. Cns and Neurological Disorders. 4: 51-61. PMID 15723613 DOI: 10.2174/1568007053005082 |
0.567 |
|
| 2004 |
Davidson TJ, Harel S, Arboleda VA, Prunell GF, Shelanski ML, Greene LA, Troy CM. Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10040-6. PMID 15537872 DOI: 10.1523/Jneurosci.3643-04.2004 |
0.732 |
|
| 2004 |
Prunell GF, Troy CM. Balancing neuronal death. Journal of Neuroscience Research. 78: 1-6. PMID 15372573 DOI: 10.1002/jnr.20252 |
0.58 |
|
| 2004 |
Rabacchi SA, Friedman WJ, Shelanski ML, Troy CM. Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein. Neurobiology of Aging. 25: 1057-66. PMID 15212831 DOI: 10.1016/J.Neurobiolaging.2003.10.003 |
0.731 |
|
| 2004 |
Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L. RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons. Cell Death and Differentiation. 11: 618-30. PMID 14765136 DOI: 10.1038/Sj.Cdd.4401397 |
0.582 |
|
| 2003 |
Troy CM, Shelanski ML. Caspase-2 redux. Cell Death and Differentiation. 10: 101-7. PMID 12655298 DOI: 10.1038/sj.cdd.4401175 |
0.694 |
|
| 2002 |
Troy CM, Salvesen GS. Caspases on the brain. Journal of Neuroscience Research. 69: 145-50. PMID 12111795 DOI: 10.1002/Jnr.10294 |
0.528 |
|
| 2002 |
Troy CM, Friedman JE, Friedman WJ. Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. The Journal of Biological Chemistry. 277: 34295-302. PMID 12097334 DOI: 10.1074/Jbc.M205167200 |
0.557 |
|
| 2001 |
Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA, Shelanski ML. Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5007-16. PMID 11438576 DOI: 10.1523/Jneurosci.21-14-05007.2001 |
0.731 |
|
| 2001 |
Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA. beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. Journal of Neurochemistry. 77: 157-64. PMID 11279271 DOI: 10.1046/J.1471-4159.2001.T01-1-00218.X |
0.651 |
|
| 2001 |
Troy CM. Diversity of caspase involvement in neuronal cell death Advances in Cell Aging and Gerontology. 5: 67-92. DOI: 10.1016/S1566-3124(01)05003-9 |
0.482 |
|
| 2000 |
Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. Caspase-2 mediates neuronal cell death induced by beta-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1386-92. PMID 10662829 |
0.675 |
|
| 2000 |
Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid The Journal of Neuroscience. 20: 1386-1392. DOI: 10.1523/Jneurosci.20-04-01386.2000 |
0.72 |
|
| 1999 |
Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, Park DS, Yan CY, Troy CM, Greene LA. CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. Journal of Neurochemistry. 73: 1901-12. PMID 10537048 |
0.419 |
|
| 1998 |
Stefanis L, Troy CM, Qi H, Shelanski ML, Greene LA. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9204-15. PMID 9801360 DOI: 10.1523/Jneurosci.18-22-09204.1998 |
0.717 |
|
| 1998 |
Tenneti L, D'Emilia DM, Troy CM, Lipton SA. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. Journal of Neurochemistry. 71: 946-59. PMID 9721720 DOI: 10.1046/j.1471-4159.1998.71030946.x |
0.521 |
|
| 1998 |
Park DS, Morris EJ, Stefanis L, Troy CM, Shelanski ML, Geller HM, Greene LA. Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 830-40. PMID 9437005 DOI: 10.1523/Jneurosci.18-03-00830.1998 |
0.667 |
|
| 1998 |
Stefanis L, Troy CM, Qi H, Shelanski ML, Greene LA. Caspase-2 (Nedd-2) Processing and Death of Trophic Factor-Deprived PC12 Cells and Sympathetic Neurons Occur Independently of Caspase-3 (CPP32)-Like Activity The Journal of Neuroscience. 18: 9204-9215. DOI: 10.1523/JNEUROSCI.18-22-09204.1998 |
0.687 |
|
| 1997 |
Stefanis L, Troy CM, Qi H, Greene LA. Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support. Journal of Neurochemistry. 69: 1425-37. PMID 9326271 DOI: 10.1046/J.1471-4159.1997.69041425.X |
0.541 |
|
| 1997 |
Troy CM, Stefanis L, Greene LA, Shelanski ML. Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1911-8. PMID 9045720 DOI: 10.1523/Jneurosci.17-06-01911.1997 |
0.719 |
|
| 1997 |
Troy CM, Stefanis L, Greene LA, Shelanski ML. Mechanisms of neuronal degeneration: a final common pathway? Advances in Neurology. 72: 103-11. PMID 8993689 |
0.582 |
|
| 1996 |
Stefanis L, Park DS, Yan CY, Farinelli SE, Troy CM, Shelanski ML, Greene LA. Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis. The Journal of Biological Chemistry. 271: 30663-71. PMID 8940042 DOI: 10.1074/Jbc.271.48.30663 |
0.648 |
|
| 1996 |
Troy CM, Stefanis L, Prochiantz A, Greene LA, Shelanski ML. The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 93: 5635-40. PMID 8643629 DOI: 10.1073/Pnas.93.11.5635 |
0.633 |
|
| 1996 |
Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 253-61. PMID 8613791 DOI: 10.1523/Jneurosci.16-01-00253.1996 |
0.707 |
|
| 1996 |
Troy C, Derossi D, Prochiantz A, Greene L, Shelanski M. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway The Journal of Neuroscience. 16: 253-261. DOI: 10.1523/JNEUROSCI.16-01-00253.1996 |
0.532 |
|
| 1994 |
Troy CM, Shelanski ML. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 6384-7. PMID 8022792 DOI: 10.1073/pnas.91.14.6384 |
0.663 |
|
| 1994 |
Shelanski ML, Frappier T, Georgieff I, Troy C, Mellado W. Cytoskeletons of central and peripheral neurons. Journal of the Neurological Sciences. 124: 33-7. PMID 7807139 DOI: 10.1016/0022-510X(94)90174-0 |
0.569 |
|
| 1992 |
Troy CM, Greene LA, Shelanski ML. Neurite outgrowth in peripherin-depleted PC12 cells. The Journal of Cell Biology. 117: 1085-92. PMID 1577867 DOI: 10.1083/jcb.117.5.1085 |
0.591 |
|
| 1990 |
Troy CM, Brown K, Greene LA, Shelanski ML. Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo. Neuroscience. 36: 217-37. PMID 2215919 DOI: 10.1016/0306-4522(90)90364-A |
0.582 |
|
| 1990 |
Troy CM, Muma NA, Greene LA, Price DL, Shelanski ML. Regulation of peripherin and neurofilament expression in regenerating rat motor neurons. Brain Research. 529: 232-8. PMID 2126481 DOI: 10.1016/0006-8993(90)90832-V |
0.561 |
|
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