Carol M. Troy - Publications

Columbia University, New York, NY 
Neuronal Apoptosis

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Montroull LE, Rothbard DE, Kanal HD, D'Mello V, Dodson V, Troy CM, Zanin JP, Levison SW, Friedman WJ. Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice. Asn Neuro. 12: 1759091420930865. PMID 32493127 DOI: 10.1177/1759091420930865  0.48
2016 Troy CM, Shelanski ML. Caspase-2 and tau-a toxic partnership? Nature Medicine. 22: 1207-1208. PMID 27824824 DOI: 10.1038/nm.4227  1
2015 Jean YY, Baleriola J, Fà M, Hengst U, Troy CM. Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus. Journal of Visualized Experiments : Jove. e52805. PMID 26132278 DOI: 10.3791/52805  1
2015 Baleriola J, Jean Y, Troy C, Hengst U. Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization. Journal of Visualized Experiments : Jove. e52799. PMID 26131922 DOI: 10.3791/52799  1
2015 Troy CM, Jean YY. Caspases: therapeutic targets in neurologic disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 42-8. PMID 25339539 DOI: 10.1007/s13311-014-0307-9  1
2014 Blanch RJ, Ahmed Z, Thompson AR, Akpan N, Snead DR, Berry M, Troy CM, Scott RA, Logan A. Caspase-9 mediates photoreceptor death after blunt ocular trauma. Investigative Ophthalmology & Visual Science. 55: 6350-7. PMID 25190658 DOI: 10.1167/iovs.13-13708  1
2014 Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U. Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell. 158: 1159-72. PMID 25171414 DOI: 10.1016/j.cell.2014.07.001  1
2014 Vigneswara V, Akpan N, Berry M, Logan A, Troy CM, Ahmed Z. Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling. Brain : a Journal of Neurology. 137: 1656-75. PMID 24727569 DOI: 10.1093/brain/awu037  1
2013 Jean YY, Ribe EM, Pero ME, Moskalenko M, Iqbal Z, Marks LJ, Greene LA, Troy CM. Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. The Biochemical Journal. 455: 15-25. PMID 23815625 DOI: 10.1042/BJ20130556  1
2013 Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O, Shelanski M. Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nature Communications. 4: 1939. PMID 23748737 DOI: 10.1038/ncomms2927  1
2013 Akpan N, Troy CM. Caspase inhibitors: prospective therapies for stroke. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 19: 129-36. PMID 22645109 DOI: 10.1177/1073858412447875  1
2012 Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L. Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection. Molecular Neurodegeneration. 7: 60. PMID 23217200 DOI: 10.1186/1750-1326-7-60  1
2012 Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM. Neuronal caspase 2 activity and function requires RAIDD, but not PIDD. The Biochemical Journal. 444: 591-9. PMID 22515271 DOI: 10.1042/BJ20111588  1
2011 Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, Salvesen GS, Connolly ES, Troy CM. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8894-904. PMID 21677173 DOI: 10.1523/JNEUROSCI.0698-11.2011  1
2011 Puzzo D, Privitera L, Fa' M, Staniszewski A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O. Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory. Annals of Neurology. 69: 819-30. PMID 21472769 DOI: 10.1002/ana.22313  1
2011 Troy CM, Akpan N, Jean YY. Regulation of caspases in the nervous system implications for functions in health and disease. Progress in Molecular Biology and Translational Science. 99: 265-305. PMID 21238939 DOI: 10.1016/B978-0-12-385504-6.00007-5  1
2010 Tizon B, Ribe EM, Mi W, Troy CM, Levy E. Cystatin C protects neuronal cells from amyloid-beta-induced toxicity. Journal of Alzheimer's Disease : Jad. 19: 885-94. PMID 20157244 DOI: 10.3233/JAD-2010-1291  1
2009 Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8828-38. PMID 19587290 DOI: 10.1523/JNEUROSCI.1779-09.2009  1
2009 Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT. The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1011-6. PMID 19176810 DOI: 10.1523/JNEUROSCI.5175-08.2009  1
2008 Troy CM, Ribe EM. Caspase-2: vestigial remnant or master regulator? Science Signaling. 1: pe42. PMID 18812565 DOI: 10.1126/scisignal.138pe42  1
2008 Ribe EM, Serrano-Saiz E, Akpan N, Troy CM. Mechanisms of neuronal death in disease: defining the models and the players. The Biochemical Journal. 415: 165-82. PMID 18800967 DOI: 10.1042/BJ20081118  1
2007 Biswas SC, Shi Y, Vonsattel JP, Leung CL, Troy CM, Greene LA. Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 893-900. PMID 17251431 DOI: 10.1523/JNEUROSCI.3524-06.2007  1
2007 Greene LA, Liu DX, Troy CM, Biswas SC. Cell cycle molecules define a pathway required for neuron death in development and disease. Biochimica Et Biophysica Acta. 1772: 392-401. PMID 17229557 DOI: 10.1016/j.bbadis.2006.12.003  1
2006 Wang Q, Maniati M, Jabado O, Pavlaki M, Troy CM, Greene LA, Stefanis L. RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal. Cell Death and Differentiation. 13: 75-83. PMID 15947787 DOI: 10.1038/sj.cdd.4401690  1
2005 Prunell GF, Arboleda VA, Troy CM. Caspase function in neuronal death: delineation of the role of caspases in ischemia. Current Drug Targets. Cns and Neurological Disorders. 4: 51-61. PMID 15723613 DOI: 10.2174/1568007053005082  1
2004 Davidson TJ, Harel S, Arboleda VA, Prunell GF, Shelanski ML, Greene LA, Troy CM. Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10040-6. PMID 15537872 DOI: 10.1523/JNEUROSCI.3643-04.2004  1
2004 Prunell GF, Troy CM. Balancing neuronal death. Journal of Neuroscience Research. 78: 1-6. PMID 15372573 DOI: 10.1002/jnr.20252  1
2004 Rabacchi SA, Friedman WJ, Shelanski ML, Troy CM. Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein. Neurobiology of Aging. 25: 1057-66. PMID 15212831 DOI: 10.1016/j.neurobiolaging.2003.10.003  1
2004 Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L. RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons. Cell Death and Differentiation. 11: 618-30. PMID 14765136 DOI: 10.1038/sj.cdd.4401397  1
2003 Troy CM, Shelanski ML. Caspase-2 redux. Cell Death and Differentiation. 10: 101-7. PMID 12655298 DOI: 10.1038/sj.cdd.4401175  1
2002 Troy CM, Salvesen GS. Caspases on the brain. Journal of Neuroscience Research. 69: 145-50. PMID 12111795 DOI: 10.1002/jnr.10294  1
2002 Troy CM, Friedman JE, Friedman WJ. Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. The Journal of Biological Chemistry. 277: 34295-302. PMID 12097334 DOI: 10.1074/jbc.M205167200  1
2001 Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA, Shelanski ML. Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5007-16. PMID 11438576  1
2001 Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA. beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. Journal of Neurochemistry. 77: 157-64. PMID 11279271 DOI: 10.1046/j.1471-4159.2001.00218.x  1
2001 Troy CM. Diversity of caspase involvement in neuronal cell death Advances in Cell Aging and Gerontology. 5: 67-92. DOI: 10.1016/S1566-3124(01)05003-9  1
2000 Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. Caspase-2 mediates neuronal cell death induced by beta-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1386-92. PMID 10662829  1
1999 Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, Park DS, Yan CY, Troy CM, Greene LA. CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. Journal of Neurochemistry. 73: 1901-12. PMID 10537048  1
1998 Stefanis L, Troy CM, Qi H, Shelanski ML, Greene LA. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9204-15. PMID 9801360  1
1998 Tenneti L, D'Emilia DM, Troy CM, Lipton SA. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. Journal of Neurochemistry. 71: 946-59. PMID 9721720  1
1998 Park DS, Morris EJ, Stefanis L, Troy CM, Shelanski ML, Geller HM, Greene LA. Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 830-40. PMID 9437005  1
1997 Stefanis L, Troy CM, Qi H, Greene LA. Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support. Journal of Neurochemistry. 69: 1425-37. PMID 9326271  1
1997 Troy CM, Stefanis L, Greene LA, Shelanski ML. Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1911-8. PMID 9045720  1
1997 Troy CM, Stefanis L, Greene LA, Shelanski ML. Mechanisms of neuronal degeneration: a final common pathway? Advances in Neurology. 72: 103-11. PMID 8993689  1
1996 Stefanis L, Park DS, Yan CY, Farinelli SE, Troy CM, Shelanski ML, Greene LA. Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis. The Journal of Biological Chemistry. 271: 30663-71. PMID 8940042 DOI: 10.1074/jbc.271.48.30663  1
1996 Troy CM, Stefanis L, Prochiantz A, Greene LA, Shelanski ML. The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 93: 5635-40. PMID 8643629 DOI: 10.1073/pnas.93.11.5635  1
1996 Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 253-61. PMID 8613791  1
1994 Troy CM, Shelanski ML. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 6384-7. PMID 8022792 DOI: 10.1073/pnas.91.14.6384  1
1994 Shelanski ML, Frappier T, Georgieff I, Troy C, Mellado W. Cytoskeletons of central and peripheral neurons. Journal of the Neurological Sciences. 124: 33-7. PMID 7807139 DOI: 10.1016/0022-510X(94)90174-0  1
1992 Troy CM, Greene LA, Shelanski ML. Neurite outgrowth in peripherin-depleted PC12 cells. The Journal of Cell Biology. 117: 1085-92. PMID 1577867 DOI: 10.1083/jcb.117.5.1085  1
1990 Troy CM, Brown K, Greene LA, Shelanski ML. Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo. Neuroscience. 36: 217-37. PMID 2215919 DOI: 10.1016/0306-4522(90)90364-A  1
1990 Troy CM, Muma NA, Greene LA, Price DL, Shelanski ML. Regulation of peripherin and neurofilament expression in regenerating rat motor neurons. Brain Research. 529: 232-8. PMID 2126481 DOI: 10.1016/0006-8993(90)90832-V  1
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