John T. Isaac - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
Synaptic plasticity; synaptic function; hippocampus; barrel cortex; AMPAR; kianate receptor

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Petrus E, Saar G, Ma Z, Dodd S, Isaac JTR, Koretsky AP. Interhemispheric plasticity is mediated by maximal potentiation of callosal inputs. Proceedings of the National Academy of Sciences of the United States of America. PMID 30846552 DOI: 10.1073/pnas.1810132116  0.56
2017 Terashima A, Suh YH, Isaac JTR. The AMPA Receptor Subunit GluA1 is Required for CA1 Hippocampal Long-Term Potentiation but is not Essential for Synaptic Transmission. Neurochemical Research. PMID 29098531 DOI: 10.1007/s11064-017-2425-3  0.68
2017 Chung S, Jeong JH, Ko S, Yu X, Kim YH, Isaac JTR, Koretsky AP. Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs. Cell Reports. 19: 2707-2717. PMID 28658619 DOI: 10.1016/j.celrep.2017.06.018  0.56
2017 Jackson JS, Witton J, Johnson JD, Ahmed Z, Ward M, Randall AD, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC. Altered Synapse Stability in the Early Stages of Tauopathy. Cell Reports. 18: 3063-3068. PMID 28355559 DOI: 10.1016/j.celrep.2017.03.013  0.92
2017 Teles-Grilo Ruivo LM, Baker KL, Conway MW, Kinsley PJ, Gilmour G, Phillips KG, Isaac JT, Lowry JP, Mellor JR. Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales. Cell Reports. 18: 905-917. PMID 28122241 DOI: 10.1016/j.celrep.2016.12.085  0.48
2016 Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, ... ... Isaac JT, et al. Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. Nature Medicine. PMID 27820603 DOI: 10.1038/nm.4221  0.76
2015 Dennis SH, Pasqui F, Colvin EM, Sanger H, Mogg AJ, Felder CC, Broad LM, Fitzjohn SM, Isaac JT, Mellor JR. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus. Cerebral Cortex (New York, N.Y. : 1991). PMID 26472558 DOI: 10.1093/cercor/bhv227  0.48
2015 L?rincz ML, Gunner D, Bao Y, Connelly WM, Isaac JT, Hughes SW, Crunelli V. A distinct class of slow (~0.2-2 Hz) intrinsically bursting layer 5 pyramidal neurons determines UP/DOWN state dynamics in the neocortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5442-58. PMID 25855163 DOI: 10.1523/JNEUROSCI.3603-14.2015  0.48
2015 Crocker-Buque A, Brown SM, Kind PC, Isaac JT, Daw MI. Experience-Dependent, Layer-Specific Development of Divergent Thalamocortical Connectivity. Cerebral Cortex (New York, N.Y. : 1991). 25: 2255-66. PMID 24610243 DOI: 10.1093/cercor/bhu031  0.48
2014 Dage JL, Colvin EM, Fouillet A, Langron E, Roell WC, Li J, Mathur SX, Mogg AJ, Schmitt MG, Felder CC, Merchant KM, Isaac J, Broad LM, Sher E, Ursu D. Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons. Psychopharmacology. 231: 1105-24. PMID 24429870 DOI: 10.1007/s00213-013-3384-2  1
2014 Morita D, Rah JC, Isaac JT. Incorporation of inwardly rectifying AMPA receptors at silent synapses during hippocampal long-term potentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130156. PMID 24298157 DOI: 10.1098/rstb.2013.0156  1
2013 Rah JC, Bas E, Colonell J, Mishchenko Y, Karsh B, Fetter RD, Myers EW, Chklovskii DB, Svoboda K, Harris TD, Isaac JT. Thalamocortical input onto layer 5 pyramidal neurons measured using quantitative large-scale array tomography. Frontiers in Neural Circuits. 7: 177. PMID 24273494 DOI: 10.3389/fncir.2013.00177  1
2013 Crabtree JW, Lodge D, Bashir ZI, Isaac JT. GABAA , NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus. The European Journal of Neuroscience. 37: 850-9. PMID 23294136 DOI: 10.1111/ejn.12098  1
2012 Kato AS, Knierman MD, Siuda ER, Isaac JT, Nisenbaum ES, Bredt DS. Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15296-308. PMID 23115168 DOI: 10.1523/JNEUROSCI.0705-12.2012  1
2012 Yu X, Chung S, Chen DY, Wang S, Dodd SJ, Walters JR, Isaac JT, Koretsky AP. Thalamocortical inputs show post-critical-period plasticity. Neuron. 74: 731-42. PMID 22632730 DOI: 10.1016/j.neuron.2012.04.024  1
2011 Ashby MC, Isaac JT. Maturation of a recurrent excitatory neocortical circuit by experience-dependent unsilencing of newly formed dendritic spines. Neuron. 70: 510-21. PMID 21555076 DOI: 10.1016/j.neuron.2011.02.057  1
2011 Matta JA, Ashby MC, Sanz-Clemente A, Roche KW, Isaac JT. mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. Neuron. 70: 339-51. PMID 21521618 DOI: 10.1016/j.neuron.2011.02.045  1
2011 Bortolotto ZA, Amici M, Anderson WW, Isaac JT, Collingridge GL. Synaptic plasticity in the hippocampal slice preparation. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 6.13. PMID 21207366 DOI: 10.1002/0471142301.ns0613s54  1
2011 Jouhanneau JS, Ball SM, Molnár E, Isaac JT. Mechanisms of bi-directional modulation of thalamocortical transmission in barrel cortex by presynaptic kainate receptors. Neuropharmacology. 60: 832-41. PMID 21187105 DOI: 10.1016/j.neuropharm.2010.12.023  1
2010 Brown JT, Weatherall KL, Corria LR, Chater TE, Isaac JT, Marrion NV. Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft. Frontiers in Synaptic Neuroscience. 2: 15. PMID 21423501 DOI: 10.3389/fnsyn.2010.00015  1
2010 Chittajallu R, Isaac JT. Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci. Nature Neuroscience. 13: 1240-8. PMID 20871602 DOI: 10.1038/nn.2639  1
2010 Sanz-Clemente A, Matta JA, Isaac JT, Roche KW. Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Neuron. 67: 984-96. PMID 20869595 DOI: 10.1016/j.neuron.2010.08.011  1
2010 Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, Pak DT. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nature Neuroscience. 13: 1199-207. PMID 20802490 DOI: 10.1038/nn.2624  1
2010 Chakrabarti L, Best TK, Cramer NP, Carney RS, Isaac JT, Galdzicki Z, Haydar TF. Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nature Neuroscience. 13: 927-34. PMID 20639873 DOI: 10.1038/nn.2600  1
2010 Suh YH, Terashima A, Petralia RS, Wenthold RJ, Isaac JT, Roche KW, Roche PA. A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking. Nature Neuroscience. 13: 338-43. PMID 20118925 DOI: 10.1038/nn.2488  1
2010 Nasu-Nishimura Y, Jaffe H, Isaac JT, Roche KW. Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6. The Journal of Biological Chemistry. 285: 2847-56. PMID 19920140 DOI: 10.1074/jbc.M109.081141  1
2009 Walker CS, Jensen S, Ellison M, Matta JA, Lee WY, Imperial JS, Duclos N, Brockie PJ, Madsen DM, Isaac JT, Olivera B, Maricq AV. A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Current Biology : Cb. 19: 900-8. PMID 19481459 DOI: 10.1016/j.cub.2009.05.017  1
2009 Isaac JT, Buchanan KA, Muller RU, Mellor JR. Hippocampal place cell firing patterns can induce long-term synaptic plasticity in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6840-50. PMID 19474311 DOI: 10.1523/JNEUROSCI.0731-09.2009  1
2009 Isaac JT, Feldmeyer D. Mechanisms of neocortical development. The Journal of Physiology. 587: 1871-2. PMID 19406884 DOI: 10.1113/jphysiol.2009.171470  1
2009 Lüscher C, Isaac JT. The synapse: center stage for many brain diseases. The Journal of Physiology. 587: 727-9. PMID 19074963 DOI: 10.1113/jphysiol.2008.167742  1
2008 Mistry RB, Isaac JT, Crabtree JW. Two differential frequency-dependent mechanisms regulating tonic firing of thalamic reticular neurons. The European Journal of Neuroscience. 27: 2643-56. PMID 18547248 DOI: 10.1111/j.1460-9568.2008.06246.x  0.84
2008 Terashima A, Pelkey KA, Rah JC, Suh YH, Roche KW, Collingridge GL, McBain CJ, Isaac JT. An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity. Neuron. 57: 872-82. PMID 18367088 DOI: 10.1016/j.neuron.2008.01.028  1
2007 Daw M, Isaac J. Electrophysiological recordings from neonatal neocortical brain slices Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 6.23. PMID 18428662  1
2007 Isaac JT, Ashby MC, McBain CJ. The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron. 54: 859-71. PMID 17582328 DOI: 10.1016/j.neuron.2007.06.001  1
2007 Daw MI, Ashby MC, Isaac JT. Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex. Nature Neuroscience. 10: 453-61. PMID 17351636 DOI: 10.1038/nn1866  1
2007 Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JT, Bortolotto ZA, Wang YT, Collingridge GL. LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron. 53: 703-17. PMID 17329210 DOI: 10.1016/j.neuron.2007.01.029  1
2007 Daw MI, Scott HL, Isaac JT. Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and roles. Molecular and Cellular Neurosciences. 34: 493-502. PMID 17329121 DOI: 10.1016/j.mcn.2007.01.001  1
2007 Scott HL, Braud S, Bannister NJ, Isaac JT. Synaptic strength at the thalamocortical input to layer IV neonatal barrel cortex is regulated by protein kinase C. Neuropharmacology. 52: 185-92. PMID 16890249 DOI: 10.1016/j.neuropharm.2006.06.016  1
2006 Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, et al. Recent advances in basic neurosciences and brain disease: from synapses to behavior. Molecular Pain. 2: 38. PMID 17196111 DOI: 10.1186/1744-8069-2-38  1
2006 Nasu-Nishimura Y, Hurtado D, Braud S, Tang TT, Isaac JT, Roche KW. Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7014-21. PMID 16807331 DOI: 10.1523/JNEUROSCI.0573-06.2006  1
2006 Lauri SE, Vesikansa A, SegerstrÃ¥le M, Collingridge GL, Isaac JT, Taira T. Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release. Neuron. 50: 415-29. PMID 16675396 DOI: 10.1016/j.neuron.2006.03.020  1
2006 Daw MI, Bannister NV, Isaac JT. Rapid, activity-dependent plasticity in timing precision in neonatal barrel cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4178-87. PMID 16624938 DOI: 10.1523/JNEUROSCI.0150-06.2006  1
2006 Chen BS, Braud S, Badger JD, Isaac JT, Roche KW. Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. The Journal of Biological Chemistry. 281: 16583-90. PMID 16606616 DOI: 10.1074/jbc.M513029200  1
2006 Plant K, Pelkey KA, Bortolotto ZA, Morita D, Terashima A, McBain CJ, Collingridge GL, Isaac JT. Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation. Nature Neuroscience. 9: 602-4. PMID 16582904 DOI: 10.1038/nn1678  1
2005 Palmer CL, Lim W, Hastie PG, Toward M, Korolchuk VI, Burbidge SA, Banting G, Collingridge GL, Isaac JT, Henley JM. Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron. 47: 487-94. PMID 16102532 DOI: 10.1016/j.neuron.2005.06.014  1
2005 Maingret F, Lauri SE, Taira T, Isaac JT. Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations. The Journal of Physiology. 567: 131-42. PMID 15946969 DOI: 10.1113/jphysiol.2005.089474  0.76
2005 Bannister NJ, Benke TA, Mellor J, Scott H, Gürdal E, Crabtree JW, Isaac JT. Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5259-71. PMID 15917466 DOI: 10.1523/JNEUROSCI.0827-05.2005  1
2005 Kim CH, Braud S, Isaac JT, Roche KW. Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations. The Journal of Biological Chemistry. 280: 25409-15. PMID 15894802 DOI: 10.1074/jbc.M502644200  1
2005 Lauri SE, SegerstrÃ¥le M, Vesikansa A, Maingret F, Mulle C, Collingridge GL, Isaac JT, Taira T. Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4473-84. PMID 15872094 DOI: 10.1523/JNEUROSCI.4050-04.2005  1
2004 Isaac JT, Mellor J, Hurtado D, Roche KW. Kainate receptor trafficking: physiological roles and molecular mechanisms. Pharmacology & Therapeutics. 104: 163-72. PMID 15556673 DOI: 10.1016/j.pharmthera.2004.08.006  1
2004 Collingridge GL, Isaac JT, Wang YT. Receptor trafficking and synaptic plasticity. Nature Reviews. Neuroscience. 5: 952-62. PMID 15550950 DOI: 10.1038/nrn1556  1
2004 Lüthi A, Wikström MA, Palmer MJ, Matthews P, Benke TA, Isaac JT, Collingridge GL. Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. Bmc Neuroscience. 5: 44. PMID 15538948 DOI: 10.1186/1471-2202-5-44  1
2004 Terashima A, Cotton L, Dev KK, Meyer G, Zaman S, Duprat F, Henley JM, Collingridge GL, Isaac JT. Regulation of synaptic strength and AMPA receptor subunit composition by PICK1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5381-90. PMID 15190111 DOI: 10.1523/JNEUROSCI.4378-03.2004  1
2004 Palmer MJ, Isaac JT, Collingridge GL. Multiple, developmentally regulated expression mechanisms of long-term potentiation at CA1 synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4903-11. PMID 15163681 DOI: 10.1523/JNEUROSCI.0170-04.2004  1
2003 Hayes DM, Braud S, Hurtado DE, McCallum J, Standley S, Isaac JT, Roche KW. Trafficking and surface expression of the glutamate receptor subunit, KA2. Biochemical and Biophysical Research Communications. 310: 8-13. PMID 14511640 DOI: 10.1016/j.bbrc.2003.08.115  1
2003 Collingridge GL, Isaac JT. Functional roles of protein interactions with AMPA and kainate receptors. Neuroscience Research. 47: 3-15. PMID 12941441 DOI: 10.1016/S0168-0102(03)00160-3  1
2003 Isaac JT. Postsynaptic silent synapses: evidence and mechanisms. Neuropharmacology. 45: 450-60. PMID 12907306 DOI: 10.1016/S0028-3908(03)00229-6  1
2003 Lauri SE, Bortolotto ZA, Nistico R, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL. A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron. 39: 327-41. PMID 12873388 DOI: 10.1016/S0896-6273(03)00369-6  1
2003 Duprat F, Daw M, Lim W, Collingridge G, Isaac J. GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity Philosophical Transactions of the Royal Society B: Biological Sciences. 358: 715-720. PMID 12740117 DOI: 10.1098/rstb.2002.1215  1
2003 Bortolotto ZA, Lauri S, Isaac JT, Collingridge GL. Kainate receptors and the induction of mossy fibre long-term potentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 657-66. PMID 12740111 DOI: 10.1098/rstb.2002.1216  1
2003 Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron. 37: 625-38. PMID 12597860 DOI: 10.1016/S0896-6273(02)01191-1  1
2002 Molnar E, Isaac JT. Developmental and activity dependent regulation of ionotropic glutamate receptors at synapses. Thescientificworldjournal. 2: 27-47. PMID 12806037 DOI: 10.1100/tsw.2002.74  1
2002 Crabtree JW, Isaac JT. New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8754-61. PMID 12351751  0.84
2002 Daw MI, Bortolotto ZA, Saulle E, Zaman S, Collingridge GL, Isaac JT. Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression. Nature Neuroscience. 5: 835-6. PMID 12161757 DOI: 10.1038/nn903  1
2002 Kidd FL, Coumis U, Collingridge GL, Crabtree JW, Isaac JT. A presynaptic kainate receptor is involved in regulating the dynamic properties of thalamocortical synapses during development. Neuron. 34: 635-46. PMID 12062046 DOI: 10.1016/S0896-6273(02)00699-2  1
2001 Bortolotto ZA, Anderson WW, Isaac JT, Collingridge GL. Synaptic plasticity in the hippocampal slice preparation. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 6.13. PMID 18428512 DOI: 10.1002/0471142301.ns0613s16  1
2001 Isaac J. Protein phosphatase 1 and LTD: Synapses are the architects of depression Neuron. 32: 963-966. PMID 11754828 DOI: 10.1016/S0896-6273(01)00545-1  1
2001 Lauri SE, Delany C, J Clarke VR, Bortolotto ZA, Ornstein PL, T R Isaac J, Collingridge GL. Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses. Neuropharmacology. 41: 907-15. PMID 11747895 DOI: 10.1016/S0028-3908(01)00152-6  1
2001 Benke TA, Lüthi A, Palmer MJ, Wikström MA, Anderson WW, Isaac JT, Collingridge GL. Mathematical modelling of non-stationary fluctuation analysis for studying channel properties of synaptic AMPA receptors. The Journal of Physiology. 537: 407-20. PMID 11731574 DOI: 10.1111/j.1469-7793.2001.00407.x  1
2001 Lauri SE, Bortolotto ZA, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL. A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP. Neuron. 32: 697-709. PMID 11719209 DOI: 10.1016/S0896-6273(01)00511-6  1
2001 Kidd FL, Isaac JT. Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance. Journal of Neurophysiology. 86: 1139-48. PMID 11535664  0.64
2000 Daw MI, Chittajallu R, Bortolotto ZA, Dev KK, Duprat F, Henley JM, Collingridge GL, Isaac JT. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 28: 873-86. PMID 11163273 DOI: 10.1016/S0896-6273(00)00160-4  1
2000 Kidd FL, Isaac JT. Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex. Neuropharmacology. 39: 725-32. PMID 10699439  0.64
1999 Lüthi A, Chittajallu R, Duprat F, Palmer MJ, Benke TA, Kidd FL, Henley JM, Isaac JT, Collingridge GL. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 24: 389-99. PMID 10571232 DOI: 10.1016/S0896-6273(00)80852-1  1
1999 Isaac JT, Nicoll RA, Malenka RC. Silent glutamatergic synapses in the mammalian brain. Canadian Journal of Physiology and Pharmacology. 77: 735-7. PMID 10566951  1
1999 Kidd FL, Isaac JT. Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses. Nature. 400: 569-73. PMID 10448859 DOI: 10.1038/23040  0.64
1999 Hjelmstad GO, Isaac JT, Nicoll RA, Malenka RC. Lack of AMPA receptor desensitization during basal synaptic transmission in the hippocampal slice. Journal of Neurophysiology. 81: 3096-9. PMID 10368425  1
1999 Fox K, Henley J, Isaac J. Experience-dependent development of NMDA receptor transmission Nature Neuroscience. 2: 297-299. PMID 10204530 DOI: 10.1038/7203  1
1998 Crabtree JW, Collingridge GL, Isaac JT. A new intrathalamic pathway linking modality-related nuclei in the dorsal thalamus. Nature Neuroscience. 1: 389-94. PMID 10196529 DOI: 10.1038/1603  1
1998 Isaac JT, Lüthi A, Palmer MJ, Anderson WW, Benke TA, Collingridge GL. An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings. Neuropharmacology. 37: 1399-410. PMID 9849675 DOI: 10.1016/S0028-3908(98)00140-3  1
1998 Feldman DE, Nicoll RA, Malenka RC, Isaac JT. Long-term depression at thalamocortical synapses in developing rat somatosensory cortex. Neuron. 21: 347-57. PMID 9728916  1
1998 Nishimune A, Isaac JT, Molnar E, Noel J, Nash SR, Tagaya M, Collingridge GL, Nakanishi S, Henley JM. NSF binding to GluR2 regulates synaptic transmission. Neuron. 21: 87-97. PMID 9697854 DOI: 10.1016/S0896-6273(00)80517-6  1
1998 Benke TA, Lüthi A, Isaac JT, Collingridge GL. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature. 393: 793-7. PMID 9655394 DOI: 10.1038/31709  1
1997 Turner DA, Chen Y, Isaac JT, West M, Wheal HV. Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in rat hippocampus in vitro. The Journal of Physiology. 500: 441-61. PMID 9147329  1
1997 Isaac JT, Crair MC, Nicoll RA, Malenka RC. Silent synapses during development of thalamocortical inputs. Neuron. 18: 269-80. PMID 9052797 DOI: 10.1016/S0896-6273(00)80267-6  1
1996 Isaac JT, Oliet SH, Hjelmstad GO, Nicoll RA, Malenka RC. Expression mechanisms of long-term potentiation in the hippocampus. Journal of Physiology, Paris. 90: 299-303. PMID 9089495 DOI: 10.1016/S0928-4257(97)87901-6  1
1996 Isaac JT, Hjelmstad GO, Nicoll RA, Malenka RC. Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8710-5. PMID 8710936 DOI: 10.1073/pnas.93.16.8710  1
1995 Isaac JT, Nicoll RA, Malenka RC. Evidence for silent synapses: implications for the expression of LTP. Neuron. 15: 427-34. PMID 7646894 DOI: 10.1016/0896-6273(95)90046-2  1
1993 Isaac JT, Wheal HV. The local anaesthetic QX-314 enables enhanced whole-cell recordings of excitatory synaptic currents in rat hippocampal slices in vitro. Neuroscience Letters. 150: 227-30. PMID 8385755 DOI: 10.1016/0304-3940(93)90542-S  1
1993 Isaac J, Chen Y, Turner DA, Wheal HV. Non-equivalent subsets of minimal EPSCs recorded from rat hippocampal CA1 pyramidal cells in vitro Journal of Physiology. 473: 172P.  1
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