Florian T. Merkle, Ph.D. - Publications

2007 Neuroscience University of California, San Francisco, San Francisco, CA 
Neural stem cells

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chen HC, Mazzaferro S, Tian T, Mali I, Merkle FT. Differentiation, Transcriptomic Profiling, and Calcium Imaging of Human Hypothalamic Neurons. Current Protocols. 3: e786. PMID 37272700 DOI: 10.1002/cpz1.786  0.371
2022 Andrews PW, Barbaric I, Benvenisty N, Draper JS, Ludwig T, Merkle FT, Sato Y, Spits C, Stacey GN, Wang H, Pera MF. The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells. Cell Stem Cell. 29: 1624-1636. PMID 36459966 DOI: 10.1016/j.stem.2022.11.006  0.32
2021 Harding EC, Ba W, Zahir R, Yu X, Yustos R, Hsieh B, Lignos L, Vyssotski AL, Merkle FT, Constandinou TG, Franks NP, Wisden W. Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature. Frontiers in Neuroscience. 15: 709825. PMID 34720852 DOI: 10.3389/fnins.2021.709825  0.675
2021 Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov RA, Léon S, Matias I, Zizzari P, Quarta C, Cannich A, Meece K, Gonzales D, Clark S, ... ... Merkle FT, et al. Functional heterogeneity of POMC neurons relies on mTORC1 signaling. Cell Reports. 37: 109800. PMID 34644574 DOI: 10.1016/j.celrep.2021.109800  0.305
2021 Buecker C, Merkle FT. Science shines in a new virtual SY-Stem. Development (Cambridge, England). 148. PMID 34170290 DOI: 10.1242/dev.188367  0.329
2021 Buecker C, Merkle FT. Science shines in a new virtual SY-Stem. Development (Cambridge, England). 148. PMID 34170290 DOI: 10.1242/dev.188367  0.329
2021 Jerber J, Seaton DD, Cuomo ASE, Kumasaka N, Haldane J, Steer J, Patel M, Pearce D, Andersson M, Bonder MJ, Mountjoy E, Ghoussaini M, Lancaster MA, Marioni JC, ... Merkle FT, et al. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nature Genetics. PMID 33664506 DOI: 10.1038/s41588-021-00801-6  0.416
2020 Sonoyama T, Stadler LKJ, Zhu M, Keogh JM, Henning E, Hisama F, Kirwan P, Jura M, Blaszczyk BK, DeWitt DC, Brouwers B, Hyvönen M, Barroso I, Merkle FT, Appleyard SM, et al. Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities. Scientific Reports. 10: 9028. PMID 32493978 DOI: 10.1038/S41598-020-65531-X  0.338
2019 Razolli D, de Araújo T, Sant'Ana M, Kirwan P, Cintra D, Merkle F, Velloso L. POMC processing in the hypothalamus is directly regulated by saturated fat - implications for the development of obesity. Neuroendocrinology. PMID 31104058 DOI: 10.1159/000501023  0.344
2018 Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Molecular Metabolism. PMID 29439854 DOI: 10.1016/J.Molmet.2018.01.021  0.345
2017 Kirwan P, Jura M, Merkle FT. Generation and Characterization of Functional Human Hypothalamic Neurons. Current Protocols in Neuroscience. 81: 3.33.1-3.33.24. PMID 29064566 DOI: 10.1002/Cpns.40  0.494
2017 Merkle FT, Ghosh S, Kamitaki N, Mitchell J, Avior Y, Mello C, Kashin S, Mekhoubad S, Ilic D, Charlton M, Saphier G, Handsaker RE, Genovese G, Bar S, Benvenisty N, et al. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. PMID 28445466 DOI: 10.1038/Nature22312  0.374
2017 Carver A, Merkle FT, Eggan K. Culturing human pluripotent stem cells from diverse culture histories Protocol Exchange. DOI: 10.1038/Protex.2017.087  0.385
2016 Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Current Protocols in Stem Cell Biology. 38: 5B.6.1-5B.6.60. PMID 27532820 DOI: 10.1002/Cpsc.15  0.364
2015 Merkle FT, Neuhausser WM, Santos D, Valen E, Gagnon JA, Maas K, Sandoe J, Schier AF, Eggan K. Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus. Cell Reports. 11: 875-83. PMID 25937281 DOI: 10.1016/J.Celrep.2015.04.007  0.324
2015 Liu J, Merkle FT, Gandhi AV, Gagnon JA, Woods IG, Chiu CN, Shimogori T, Schier AF, Prober DA. Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development (Cambridge, England). 142: 1113-24. PMID 25725064 DOI: 10.1242/Dev.117424  0.423
2015 Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (Cambridge, England). 142: 633-43. PMID 25670790 DOI: 10.1242/Dev.117978  0.518
2014 Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, et al. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 14: 781-95. PMID 24704492 DOI: 10.1016/J.Stem.2014.03.004  0.403
2014 Merkle FT, Fuentealba LC, Sanders TA, Magno L, Kessaris N, Alvarez-Buylla A. Adult neural stem cells in distinct microdomains generate previously unknown interneuron types. Nature Neuroscience. 17: 207-14. PMID 24362763 DOI: 10.1038/Nn.3610  0.682
2014 Kiskinis E, Sandoe J, Williams L, Boulting G, Moccia R, Wainger B, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle F, Davis-Dusenbery B, Ziller M, Oakley D, et al. Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1 Cell Stem Cell. 14: 873. DOI: 10.1016/J.Stem.2014.04.005  0.308
2013 Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I, Moccia R, Davis-Dusenbery BN, Eggan K. The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nature Neuroscience. 16: 1725-7. PMID 24185425 DOI: 10.1038/Nn.3566  0.39
2013 Merkle FT, Eggan K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell. 12: 656-68. PMID 23746975 DOI: 10.1016/J.Stem.2013.05.016  0.358
2013 Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. 12: 559-72. PMID 23642365 DOI: 10.1016/J.Stem.2013.04.008  0.474
2013 Alvarez-Buylla A, Merkle F, Fuentealba L. Neurogenesis in the Postnatal VZ-SVZ and the Origin of Interneuron Diversity Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing Cns and Pns. 537-550. DOI: 10.1016/B978-0-12-397265-1.00096-4  0.579
2012 Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science (New York, N.Y.). 337: 358-62. PMID 22745251 DOI: 10.1126/Science.1222381  0.571
2012 Seeley WW, Merkle FT, Gaus SE, Craig AD, Allman JM, Hof PR, Economo CV. Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspective. Cerebral Cortex (New York, N.Y. : 1991). 22: 245-50. PMID 21653703 DOI: 10.1093/Cercor/Bhr005  0.407
2008 Alvarez-Buylla A, Kohwi M, Nguyen TM, Merkle FT. The heterogeneity of adult neural stem cells and the emerging complexity of their niche. Cold Spring Harbor Symposia On Quantitative Biology. 73: 357-65. PMID 19022766 DOI: 10.1101/Sqb.2008.73.019  0.775
2008 Mirzadeh Z, Merkle FT, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A. Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell. 3: 265-78. PMID 18786414 DOI: 10.1016/J.Stem.2008.07.004  0.768
2008 Lledo PM, Merkle FT, Alvarez-Buylla A. Origin and function of olfactory bulb interneuron diversity. Trends in Neurosciences. 31: 392-400. PMID 18603310 DOI: 10.1016/J.Tins.2008.05.006  0.72
2007 Merkle FT, Mirzadeh Z, Alvarez-Buylla A. Mosaic organization of neural stem cells in the adult brain. Science (New York, N.Y.). 317: 381-4. PMID 17615304 DOI: 10.1126/Science.1144914  0.777
2006 Merkle FT, Alvarez-Buylla A. Neural stem cells in mammalian development. Current Opinion in Cell Biology. 18: 704-9. PMID 17046226 DOI: 10.1016/J.Ceb.2006.09.008  0.74
2005 Spassky N, Merkle FT, Flames N, Tramontin AD, García-Verdugo JM, Alvarez-Buylla A. Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10-8. PMID 15634762 DOI: 10.1523/Jneurosci.1108-04.2005  0.762
2004 Merkle FT, Tramontin AD, García-Verdugo JM, Alvarez-Buylla A. Radial glia give rise to adult neural stem cells in the subventricular zone. Proceedings of the National Academy of Sciences of the United States of America. 101: 17528-32. PMID 15574494 DOI: 10.1073/Pnas.0407893101  0.787
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