Kevin C. Eggan, PhD - Publications

2004- Stem Cell and Regenerative Biology Harvard University, Cambridge, MA, United States 
Stem Cell, Neurodegenerative diseases

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wells MF, Nemesh J, Ghosh S, Mitchell JM, Salick MR, Mello CJ, Meyer D, Pietilainen O, Piccioni F, Guss EJ, Raghunathan K, Tegtmeyer M, Hawes D, Neumann A, Worringer KA, ... ... Eggan K, et al. Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages. Cell Stem Cell. PMID 36796362 DOI: 10.1016/j.stem.2023.01.010  0.317
2022 Limone F, Guerra San Juan I, Mitchell JM, Smith JLM, Raghunathan K, Meyer D, Ghosh SD, Couto A, Klim JR, Joseph BJ, Gold J, Mello CJ, Nemesh J, Smith BM, Verhage M, ... ... Eggan K, et al. Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues. Cell Reports. 111896. PMID 36596304 DOI: 10.1016/j.celrep.2022.111896  0.36
2022 San Juan IG, Nash LA, Smith KS, Leyton-Jaimes MF, Qian M, Klim JR, Limone F, Dorr AB, Couto A, Pintacuda G, Joseph BJ, Whisenant DE, Noble C, Melnik V, Potter D, ... ... Eggan K, et al. Loss of mouse Stmn2 function causes motor neuropathy. Neuron. 110: 4031. PMID 36480942 DOI: 10.1016/j.neuron.2022.11.003  0.499
2022 Wang AY, Sheng Y, Li W, Jung D, Junek GV, Liu H, Park J, Lee D, Wang M, Maharjan S, Kumashi S, Hao J, Zhang YS, Eggan K, Wang H. A Multimodal and Multifunctional CMOS Cellular Interfacing Array for Digital Physiology and Pathology Featuring an Ultra Dense Pixel Array and Reconfigurable Sampling Rate. Ieee Transactions On Biomedical Circuits and Systems. PMID 36417722 DOI: 10.1109/TBCAS.2022.3224064  0.703
2022 Wang M, Li W, Hao J, Gonzales A, Zhao Z, Flores RS, Kuang X, Mu X, Ching T, Tang G, Luo Z, Garciamendez-Mijares CE, Sahoo JK, Wells MF, Niu G, ... ... Eggan K, et al. Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues. Nature Communications. 13: 3317. PMID 35680907 DOI: 10.1038/s41467-022-31002-2  0.699
2022 Guerra San Juan I, Nash LA, Smith KS, Leyton-Jaimes MF, Qian M, Klim JR, Limone F, Dorr AB, Couto A, Pintacuda G, Joseph BJ, Whisenant DE, Noble C, Melnik V, Potter D, ... ... Eggan K, et al. Loss of mouse Stmn2 function causes motor neuropathy. Neuron. PMID 35294901 DOI: 10.1016/j.neuron.2022.02.011  0.543
2021 Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, et al. The genetic architecture of DNA replication timing in human pluripotent stem cells. Nature Communications. 12: 6746. PMID 34799581 DOI: 10.1038/s41467-021-27115-9  0.596
2021 Fukuda A, Hazelbaker DZ, Motosugi N, Hao J, Limone F, Beccard A, Mazzucato P, Messana A, Okada C, San Juan IG, Qian M, Umezawa A, Akutsu H, Barrett LE, Eggan K. De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells. Stem Cell Reports. PMID 34416176 DOI: 10.1016/j.stemcr.2021.07.015  0.791
2021 Avior Y, Eggan K, Benvenisty N. Retraction Notice to: Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell Stem Cell. 28: 173. PMID 33433329 DOI: 10.1016/j.stem.2020.11.020  0.317
2020 Avior Y, Lezmi E, Eggan K, Benvenisty N. Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells. Cell Stem Cell. PMID 33321073 DOI: 10.1016/j.stem.2020.11.013  0.316
2020 Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, ... ... Eggan K, et al. Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. Jama Neurology. PMID 33226425 DOI: 10.1001/jamaneurol.2020.4300  0.645
2020 Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, Gillet G, van Gastel N, Wang JY, Pietilainen O, Qian M, Eggan P, Cantrell C, Mok J, Kadiu I, ... ... Eggan K, et al. C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. Nature. 582: 89-94. PMID 32483373 DOI: 10.1038/S41586-020-2288-7  0.545
2020 Hazelbaker DZ, Beccard A, Angelini G, Mazzucato P, Messana A, Lam D, Eggan K, Barrett LE. A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells. Scientific Reports. 10: 635. PMID 31959800 DOI: 10.1038/S41598-020-57500-1  0.422
2019 Avior Y, Eggan K, Benvenisty N. Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell Stem Cell. 25: 456-461. PMID 31543368 DOI: 10.1016/J.Stem.2019.09.001  0.387
2019 Shlevkov E, Basu H, Bray MA, Sun Z, Wei W, Apaydin K, Karhohs K, Chen PF, Smith JLM, Wiskow O, Roet K, Huang X, Eggan K, Carpenter AE, Kleiman RJ, et al. A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell Reports. 28: 3224-3237.e5. PMID 31533043 DOI: 10.1016/J.Celrep.2019.08.035  0.326
2019 Mukherjee-Clavin B, Mi R, Kern B, Choi IY, Lim H, Oh Y, Lannon B, Kim KJ, Bell S, Hur JK, Hwang W, Che YH, Habib O, Baloh RH, Eggan K, et al. Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder. Nature Biomedical Engineering. PMID 30962586 DOI: 10.1038/S41551-019-0381-8  0.476
2019 Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, ... ... Eggan KC, et al. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nature Neuroscience. PMID 30664768 DOI: 10.1038/S41593-018-0313-Z  0.306
2019 Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, ... Eggan K, et al. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nature Neuroscience. PMID 30643292 DOI: 10.1038/S41593-018-0300-4  0.749
2018 Thams S, Lowry ER, Larraufie MH, Spiller KJ, Li H, Williams DJ, Hoang P, Jiang E, Williams LA, Sandoe J, Eggan K, Lieberam I, Kanning KC, Stockwell BR, Henderson CE, et al. A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 30446391 DOI: 10.1016/J.Ymthe.2018.10.010  0.818
2018 Srikanth P, Lagomarsino VN, Pearse RV, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Translational Psychiatry. 8: 245. PMID 30410030 DOI: 10.1038/S41398-018-0281-9  0.323
2018 McPhie DL, Nehme R, Ravichandran C, Babb SM, Ghosh SD, Staskus A, Kalinowski A, Kaur R, Douvaras P, Du F, Ongur D, Fossati V, Eggan K, Cohen BM. Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Translational Psychiatry. 8: 230. PMID 30352993 DOI: 10.1038/S41398-018-0284-6  0.357
2018 Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K. Comparative genomic analysis of embryonic, lineage-converted, and stem cell-derived motor neurons. Development (Cambridge, England). PMID 30337375 DOI: 10.1242/Dev.168617  0.755
2018 Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathologica Communications. 6: 55. PMID 29973287 DOI: 10.1186/S40478-018-0555-8  0.337
2018 Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K. The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes & Development. PMID 29950492 DOI: 10.1101/Gad.313932.118  0.782
2018 Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V. TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific Reports. 8: 8097. PMID 29802307 DOI: 10.1038/S41598-018-26397-2  0.458
2018 Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, ... ... Eggan K, et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Reports. 23: 2509-2523. PMID 29791859 DOI: 10.1016/J.Celrep.2018.04.066  0.41
2018 Kiskinis E, Kralj JM, Zou P, Weinstein EN, Zhang H, Tsioras K, Wiskow O, Ortega JA, Eggan K, Cohen AE. All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS. Stem Cell Reports. PMID 29779896 DOI: 10.1016/J.Stemcr.2018.04.020  0.733
2017 Kawada J, Kaneda S, Kirihara T, Maroof A, Levi T, Eggan K, Fujii T, Ikeuchi Y. Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons. Stem Cell Reports. PMID 29107592 DOI: 10.1016/J.Stemcr.2017.09.021  0.303
2017 Hazelbaker DZ, Beccard A, Bara AM, Dabkowski N, Messana A, Mazzucato P, Lam D, Manning D, Eggan K, Barrett LE. A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease. Stem Cell Reports. 9: 1315-1327. PMID 29020615 DOI: 10.1016/J.Stemcr.2017.09.006  0.428
2017 Salick MR, Wells MF, Eggan K, Kaykas A. Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids. Journal of Visualized Experiments : Jove. PMID 28994790 DOI: 10.3791/56404  0.337
2017 Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem Cell Reports. PMID 28712846 DOI: 10.1016/J.Stemcr.2017.06.008  0.794
2017 Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN. Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 9: 1-4. PMID 28700896 DOI: 10.1016/J.Stemcr.2017.05.029  0.465
2017 Merkle FT, Ghosh S, Kamitaki N, Mitchell J, Avior Y, Mello C, Kashin S, Mekhoubad S, Ilic D, Charlton M, Saphier G, Handsaker RE, Genovese G, Bar S, Benvenisty N, ... ... Eggan K, et al. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. PMID 28445466 DOI: 10.1038/Nature22312  0.812
2017 Carver A, Merkle FT, Eggan K. Culturing human pluripotent stem cells from diverse culture histories Protocol Exchange. DOI: 10.1038/Protex.2017.087  0.388
2017 Resetkova N, Groff A, Sakkas D, Penzias A, Rinn JL, Eggan K. A deep dive into the human blastocyst: gene based sex differences in human embryos and the assessment of aneuploidy by transcriptome analysis - progress and limitations Fertility and Sterility. 108. DOI: 10.1016/J.Fertnstert.2017.07.460  0.329
2016 Wells MF, Salick MR, Wiskow O, Ho DJ, Worringer KA, Ihry RJ, Kommineni S, Bilican B, Klim JR, Hill EJ, Kane LT, Ye C, Kaykas A, Eggan K. Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell Stem Cell. 19: 703-708. PMID 27912091 DOI: 10.1016/J.Stem.2016.11.011  0.396
2016 Bara AM, Messana A, Herring A, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Research. 17: 441-443. PMID 27879221 DOI: 10.1016/j.scr.2016.09.008  0.392
2016 Herring A, Messana A, Bara AM, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Research. 17: 430-432. PMID 27879218 DOI: 10.1016/j.scr.2016.09.009  0.402
2016 Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proceedings of the National Academy of Sciences of the United States of America. PMID 27849576 DOI: 10.1073/Pnas.1611673113  0.311
2016 Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, ... ... Eggan K, et al. Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nature Communications. 7: 13283. PMID 27796305 DOI: 10.1038/Ncomms13283  0.445
2016 Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Current Protocols in Stem Cell Biology. 38: 5B.6.1-5B.6.60. PMID 27532820 DOI: 10.1002/Cpsc.15  0.733
2016 Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, ... ... Eggan K, et al. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Science Translational Medicine. 8: 347ra93. PMID 27412785 DOI: 10.1126/Scitranslmed.Aaf6038  0.318
2016 Ray MK, Wiskow O, King MJ, Ismail N, Ergun A, Wang Y, Plys AJ, Davis CP, Kathrein K, Sadreyev R, Borowsky ML, Eggan K, Zon L, Galloway JL, Kingston RE. CAT7 and cat7l long non-coding RNAs Tune Polycomb Repressive Complex 1 Function During Human and Zebrafish Development. The Journal of Biological Chemistry. PMID 27405765 DOI: 10.1074/Jbc.M116.730853  0.322
2016 Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience. 16: 542-53. PMID 27021939 DOI: 10.1038/nn.4273  0.359
2016 Intoh A, Suzuki N, Koszka K, Eggan K. SLC52A3, A Brown-Vialetto-van Laere Syndrome Candidate Gene is Essential for Mouse Development but Dispensable for Motor Neuron Differentiation. Human Molecular Genetics. PMID 26976849 DOI: 10.1093/Hmg/Ddw053  0.44
2015 Boer ASd, Eggan K. A perspective on stem cell modeling of amyotrophic lateral sclerosis Cell Cycle. 14: 3679-3688. PMID 26505672 DOI: 10.1080/15384101.2015.1093712  0.451
2015 Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, ... ... Eggan K, et al. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nature Methods. PMID 26237226 DOI: 10.1038/Nmeth.3507  0.45
2015 Merkle FT, Neuhausser WM, Santos D, Valen E, Gagnon JA, Maas K, Sandoe J, Schier AF, Eggan K. Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus. Cell Reports. 11: 875-83. PMID 25937281 DOI: 10.1016/J.Celrep.2015.04.007  0.803
2015 Schwarz-Romond T, Kiskinis E, Eggan K. Focus on induced pluripotency and cellular reprogramming. The Embo Journal. 34: 1435. PMID 25916828 DOI: 10.15252/Embj.201591615  0.653
2015 Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (Cambridge, England). 142: 633-43. PMID 25670790 DOI: 10.1242/Dev.117978  0.453
2015 Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, et al. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nature Communications. 6: 6171. PMID 25625564 DOI: 10.1038/Ncomms7171  0.335
2015 Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF. Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1291-306. PMID 25609642 DOI: 10.1523/Jneurosci.2126-14.2015  0.423
2015 Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, ... ... Eggan K, et al. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nature Neuroscience. 18: 17-24. PMID 25420066 DOI: 10.1038/Nn.3886  0.387
2014 Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, et al. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Reports. 9: 1173-82. PMID 25456120 DOI: 10.1016/J.Celrep.2014.10.023  0.332
2014 de Boer AS, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K. Genetic validation of a therapeutic target in a mouse model of ALS. Science Translational Medicine. 6: 248ra104. PMID 25100738 DOI: 10.1126/Scitranslmed.3009351  0.741
2014 Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, Meissner A. DNA methylation dynamics of the human preimplantation embryo. Nature. 511: 611-5. PMID 25079558 DOI: 10.1038/Nature13581  0.787
2014 Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Molecular Biology of the Cell. 25: 2571-8. PMID 25009283 DOI: 10.1091/Mbc.E14-05-1007  0.316
2014 Ichida JK, TCW J, T C W J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, ... ... Eggan K, et al. Notch inhibition allows oncogene-independent generation of iPS cells. Nature Chemical Biology. 10: 632-9. PMID 24952596 DOI: 10.1038/Nchembio.1552  0.458
2014 Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K. Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicology and Teratology. 43: 59-68. PMID 24746641 DOI: 10.1016/J.Ntt.2014.04.001  0.399
2014 Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, ... ... Eggan K, et al. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 14: 781-95. PMID 24704492 DOI: 10.1016/J.Stem.2014.03.004  0.801
2014 Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, et al. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Reports. 7: 1-11. PMID 24703839 DOI: 10.1016/J.Celrep.2014.03.019  0.797
2014 Haidet-Phillips AM, Roybon L, Gross SK, Tuteja A, Donnelly CJ, Richard JP, Ko M, Sherman A, Eggan K, Henderson CE, Maragakis NJ. Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem Cells Translational Medicine. 3: 575-85. PMID 24604284 DOI: 10.5966/Sctm.2013-0153  0.436
2014 Carter AC, Davis-Dusenbery BN, Koszka K, Ichida JK, Eggan K. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Reports. 2: 119-26. PMID 24527385 DOI: 10.1016/J.Stemcr.2013.12.010  0.434
2014 Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, ... ... Eggan KC, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 81: 536-43. PMID 24507191 DOI: 10.1016/J.Neuron.2013.12.018  0.702
2014 Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. How to make spinal motor neurons. Development (Cambridge, England). 141: 491-501. PMID 24449832 DOI: 10.1242/Dev.097410  0.406
2014 Kiskinis E, Sandoe J, Williams L, Boulting G, Moccia R, Wainger B, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle F, Davis-Dusenbery B, Ziller M, Oakley D, ... ... Eggan K, et al. Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1 Cell Stem Cell. 14: 873. DOI: 10.1016/J.Stem.2014.04.005  0.777
2013 Eggan K. Picking the lock on pluripotency. The New England Journal of Medicine. 369: 2150-2151. PMID 24283230 DOI: 10.1056/Nejmcibr1311880  0.448
2013 Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I, Moccia R, Davis-Dusenbery BN, Eggan K. The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nature Neuroscience. 16: 1725-7. PMID 24185425 DOI: 10.1038/Nn.3566  0.404
2013 Navara CS, Hornecker J, Grow D, Chaudhari S, Hornsby PJ, Ichida JK, Eggan K, McCarrey JR. Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cellular Reprogramming. 15: 495-502. PMID 24182315 DOI: 10.1089/Cell.2012.0093  0.489
2013 Sandoe J, Eggan K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models Nature Neuroscience. 16: 780-789. PMID 23799470 DOI: 10.1038/Nn.3425  0.815
2013 Merkle FT, Eggan K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell. 12: 656-68. PMID 23746975 DOI: 10.1016/J.Stem.2013.05.016  0.433
2013 Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. 12: 559-72. PMID 23642365 DOI: 10.1016/J.Stem.2013.04.008  0.45
2013 Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, ... ... Eggan KC, et al. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495: 474-80. PMID 23474986 DOI: 10.1038/Nature11923  0.357
2013 Niakan KK, Eggan K. Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Developmental Biology. 375: 54-64. PMID 23261930 DOI: 10.1016/J.Ydbio.2012.12.008  0.494
2013 Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K. Developmental bias in cleavage-stage mouse blastomeres. Current Biology : Cb. 23: 21-31. PMID 23177476 DOI: 10.1016/J.Cub.2012.10.054  0.751
2013 Roy E, Neufeld Z, Cerone L, Wong A, Hodgson S, Tabansky I, Eggan K, Livet J, Khosrotehrani K. The interfollicular epidermis is maintained by a hierarchy defined by stem cells within the non-cycling portion of hair follicles and committed progenitors Journal of Investigative Dermatology. 133. DOI: 10.1038/Jid.2013.106  0.772
2013 Boulting GL, Eggan KC. Patient-Specific Pluripotent Stem Cells Genomic and Personalized Medicine. 1: 381-390. DOI: 10.1016/B978-0-12-382227-7.00033-1  0.783
2012 Williams LA, Davis-Dusenbery BN, Eggan KC. SnapShot: directed differentiation of pluripotent stem cells. Cell. 149: 1174-1174.e1. PMID 22632979 DOI: 10.1016/J.Cell.2012.05.015  0.493
2012 Mekhoubad S, Bock C, de Boer AS, Kiskinis E, Meissner A, Eggan K. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell. 10: 595-609. PMID 22560080 DOI: 10.1016/J.Stem.2012.02.014  0.798
2011 Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. 9: 293-4. PMID 21982228 DOI: 10.1016/J.Stem.2011.08.002  0.721
2011 Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nature Communications. 2: 488. PMID 21971503 DOI: 10.1038/Ncomms1503  0.738
2011 Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 9: 205-18. PMID 21852222 DOI: 10.1016/J.Stem.2011.07.014  0.448
2011 Han SS, Williams LA, Eggan KC. Constructing and deconstructing stem cell models of neurological disease. Neuron. 70: 626-44. PMID 21609821 DOI: 10.1016/J.Neuron.2011.05.003  0.496
2011 Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, ... ... Eggan K, et al. Somatic coding mutations in human induced pluripotent stem cells. Nature. 471: 63-7. PMID 21368825 DOI: 10.1038/Nature09805  0.734
2011 Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell. 144: 439-52. PMID 21295703 DOI: 10.1016/J.Cell.2010.12.032  0.824
2011 Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, ... ... Eggan K, et al. A functionally characterized test set of human induced pluripotent stem cells. Nature Biotechnology. 29: 279-86. PMID 21293464 DOI: 10.1038/Nbt.1783  0.826
2011 Seandel M, Eggan K. Stem Cells: Doing Some Heavy Lifting at ISSCR 2011 Cell Stem Cell. 9: 311-315. DOI: 10.1016/J.Stem.2011.09.009  0.402
2010 Ichida JK, Kiskinis E, Eggan K. Shushing down the epigenetic landscape towards stem cell differentiation. Development (Cambridge, England). 137: 2455-60. PMID 20554719 DOI: 10.1242/Dev.049130  0.732
2010 Egli D, Eggan KC. Recipient cell nuclear factors are required for reprogramming by nuclear transfer Development. 137: 1953-1963. PMID 20463036 DOI: 10.1242/Dev.046151  0.648
2010 Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & Development. 24: 312-26. PMID 20123909 DOI: 10.1101/Gad.1833510  0.62
2010 Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. The Journal of Clinical Investigation. 120: 51-9. PMID 20051636 DOI: 10.1172/Jci40553  0.749
2010 Di Giorgio F, Boulting G, Kiskinis E, De Boer S, Bobrowicz S, Eggan K. C9 Can we build a human cell based model: SMA Reproductive Biomedicine Online. 20: S3. DOI: 10.1016/S1472-6483(10)62263-8  0.776
2010 Tabansky I, Draft RW, Rosains J, Livet J, Lichtman JW, Sanes JR, Eggan KC. Using the brainbow to trace lineages in early mouse development Developmental Biology. 344: 463. DOI: 10.1016/J.Ydbio.2010.05.203  0.723
2010 Lannon BM, MacCutcheon K, Penzias AS, Eggan K. Derivation of embryonic stem cells from pre-implantation genetic diagnosis embryos: possible but inefficient Fertility and Sterility. 94. DOI: 10.1016/J.Fertnstert.2010.07.031  0.395
2009 Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 5: 491-503. PMID 19818703 DOI: 10.1016/J.Stem.2009.09.012  0.795
2009 Egli D, Sandler VM, Shinohara ML, Cantor H, Eggan K. Reprogramming after chromosome transfer into mouse blastomeres. Current Biology : Cb. 19: 1403-9. PMID 19682906 DOI: 10.1016/J.Cub.2009.06.065  0.686
2009 Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM. Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nature Methods. 6: 613-8. PMID 19620972 DOI: 10.1038/Nmeth.1357  0.637
2009 Deng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, et al. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nature Biotechnology. 27: 353-60. PMID 19330000 DOI: 10.1038/Nbt.1530  0.649
2009 Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 4: 103-6. PMID 19200798 DOI: 10.1016/J.Stem.2008.12.001  0.767
2009 Lannon B, Boulting G, Mekhoubad S, MacCutcheon K, Penzias A, Eggan K. Derivation of the first human embryonic stem cell line with Charcot Marie Tooth disease Fertility and Sterility. 92: S171-S172. DOI: 10.1016/J.Fertnstert.2009.07.1332  0.805
2009 Lannon B, Mekhoubad S, Boulting G, MacCutcheon K, Penzias A, Eggan K. Derivation of a human embryonic stem cell line from a couple with a known reciprocal translocation Fertility and Sterility. 92: S171. DOI: 10.1016/J.Fertnstert.2009.07.1331  0.8
2008 Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell. 3: 637-48. PMID 19041780 DOI: 10.1016/J.Stem.2008.09.017  0.835
2008 Eggan K. Using stem cells and reprogramming to understand disease Regenerative Medicine. 3: 799-801. PMID 18947303 DOI: 10.2217/17460751.3.6.799  0.498
2008 Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (New York, N.Y.). 321: 1218-21. PMID 18669821 DOI: 10.1126/Science.1158799  0.525
2008 Egli D, Birkhoff G, Eggan K. Mediators of reprogramming: transcription factors and transitions through mitosis. Nature Reviews. Molecular Cell Biology. 9: 505-16. PMID 18568039 DOI: 10.1038/Nrm2439  0.69
2008 Eggan K. Nuclear Reprogramming in the Oocyte and Early Embryo: Applications in the Study of Human Disease. Biology of Reproduction. 78: 187-187. DOI: 10.1093/Biolreprod/78.S1.187  0.315
2007 Eggan K. Short-circuiting epiblast development. Cell Stem Cell. 1: 131-132. PMID 18371343 DOI: 10.1016/J.Stem.2007.07.018  0.496
2007 Egli D, Rosains J, Birkhoff G, Eggan K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature. 447: 679-85. PMID 17554301 DOI: 10.1038/Nature05879  0.708
2007 Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nature Neuroscience. 10: 608-14. PMID 17435754 DOI: 10.1038/Nn1885  0.525
2006 Trish E, Dimos J, Eggan K. Freezing human ES cells. Journal of Visualized Experiments : Jove. 50. PMID 18704182 DOI: 10.3791/50  0.393
2006 Trish E, Dimos J, Eggan K. Passaging HuES human embryonic stem cell-lines with trypsin. Journal of Visualized Experiments : Jove. 49. PMID 18704181 DOI: 10.3791/49  0.463
2006 Egli D, Eggan K. Nuclear transfer into mouse oocytes. Journal of Visualized Experiments. 116-116. PMID 18704178 DOI: 10.3791/116  0.707
2006 Trish E, Dimos J, Eggan K. Human ES cells: starting culture from frozen cells. Journal of Visualized Experiments : Jove. 86. PMID 18704174 DOI: 10.3791/86  0.412
2006 Sullivan S, Eggan K. The potential of cell fusion for human therapy. Stem Cell Reviews and Reports. 2: 341-349. PMID 17848721 DOI: 10.1007/Bf02698061  0.392
2006 Rodolfa KT, Eggan K. A Transcriptional Logic for Nuclear Reprogramming Cell. 126: 652-655. PMID 16923385 DOI: 10.1016/J.Cell.2006.08.009  0.454
2006 Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ. Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature. 441: 1109-14. PMID 16799565 DOI: 10.1038/Nature04929  0.388
2006 Yang X, Eggan K, Seidel G, Jaenisch R, Melton D. A simple system of checks and balances to cut fraud. Nature. 439: 782. PMID 16482128 DOI: 10.1038/439782B  0.546
2006 Trish E, Dimos J, Eggan K. Passaging HuES human embryonic stem cell-lines with trypsin Journal of Visualized Experiments. DOI: 10.3791/49  0.356
2005 Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.). 309: 1369-73. PMID 16123299 DOI: 10.1126/Science.1116447  0.667
2005 Jaenisch R, Hochedlinger K, Eggan K. Nuclear cloning, epigenetic reprogramming and cellular differentiation. Novartis Foundation Symposium. 265: 107-18; discussion 1. PMID 16050253  0.523
2004 Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K. Nuclear cloning, epigenetic reprogramming, and cellular differentiation. Cold Spring Harbor Symposia On Quantitative Biology. 69: 19-27. PMID 16117629 DOI: 10.1002/0470091452.Ch9  0.581
2004 Eggan K, Baldwin K, Tackett M, Osborne J, Gogos J, Chess A, Axel R, Jaenisch R. Mice cloned from olfactory sensory neurons. Nature. 428: 44-9. PMID 14990966 DOI: 10.1038/Nature02375  0.504
2004 Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature. 427: 148-54. PMID 14668819 DOI: 10.1038/Nature02247  0.485
2003 Eggan K, Jaenisch R. Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. Seminars in Cell & Developmental Biology. 14: 349-58. PMID 15015742 DOI: 10.1016/J.Semcdb.2003.09.012  0.484
2003 Eggan K, Jaenisch R. Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods in Enzymology. 365: 25-39. PMID 14696335 DOI: 10.1016/S0076-6879(03)65002-0  0.568
2003 Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development (Cambridge, England). 130: 1673-80. PMID 12620990 DOI: 10.1242/Dev.00366  0.55
2002 Jaenisch R, Eggan K, Humpherys D, Rideout W, Hochedlinger K. Nuclear cloning, stem cells, and genomic reprogramming. Cloning and Stem Cells. 4: 389-396. PMID 12630413 DOI: 10.1089/153623002321025069  0.557
2002 Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proceedings of the National Academy of Sciences of the United States of America. 99: 12889-94. PMID 12235366 DOI: 10.1073/Pnas.192433399  0.529
2002 Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R. Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nature Biotechnology. 20: 455-9. PMID 11981557 DOI: 10.1038/Nbt0502-455  0.807
2002 Biniszkiewicz D, Gribnau J, Ramsahoye B, Gaudet F, Eggan K, Humpherys D, Mastrangelo MA, Jun Z, Walter J, Jaenisch R. Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Molecular and Cellular Biology. 22: 2124-35. PMID 11884600 DOI: 10.1128/Mcb.22.7.2124-2135.2002  0.497
2002 Possemato R, Eggan K, Moeller BJ, Jaenisch R, Jackson-Grusby L. Flp recombinase regulated lacZ expression at the ROSA26 locus. Genesis (New York, N.Y. : 2000). 32: 184-6. PMID 11857816 DOI: 10.1002/Gene.10039  0.765
2001 Rideout WM, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science (New York, N.Y.). 293: 1093-8. PMID 11498580 DOI: 10.1126/Science.1063206  0.548
2001 Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM, Biniszkiewicz D, Yanagimachi R, Jaenisch R. Epigenetic instability in ES cells and cloned mice. Science (New York, N.Y.). 293: 95-7. PMID 11441181 DOI: 10.1126/Science.1061402  0.539
2001 Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM, Yanagimachi R, Jaenisch R. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proceedings of the National Academy of Sciences of the United States of America. 98: 6209-14. PMID 11331774 DOI: 10.1073/Pnas.101118898  0.778
2000 Eggan K, Akutsu H, Hochedlinger K, Rideout W, Yanagimachi R, Jaenisch R. X-Chromosome inactivation in cloned mouse embryos. Science (New York, N.Y.). 290: 1578-81. PMID 11090356 DOI: 10.1126/Science.290.5496.1578  0.456
2000 Rideout WM, Wakayama T, Wutz A, Eggan K, Jackson-Grusby L, Dausman J, Yanagimachi R, Jaenisch R. Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nature Genetics. 24: 109-10. PMID 10655052 DOI: 10.1038/72753  0.736
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