| Year |
Citation |
Score |
| 2023 |
Le W, Wang P, Al-Nusaif M, Zhang J, Yang H, Yang Y, Kim K, Li S, Liu C, Cai H. Pathological characteristics of axons and proteome patterns in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency. Research Square. PMID 37292937 DOI: 10.21203/rs.3.rs-2901370/v1 |
0.306 |
|
| 2023 |
Wang X, Chen X, Liu G, Cai H, Le W. The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration. International Journal of Molecular Sciences. 24. PMID 37239960 DOI: 10.3390/ijms24108614 |
0.325 |
|
| 2023 |
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H. Deficiency of Perry syndrome-associated p150 in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities. Npj Parkinson's Disease. 9: 35. PMID 36879021 DOI: 10.1038/s41531-023-00478-0 |
0.331 |
|
| 2021 |
Wang Y, Chen X, Wang Y, Li S, Cai H, Le W. The essential role of transcription factor Pitx3 in preventing mesodiencephalic dopaminergic neurodegeneration and maintaining neuronal subtype identities during aging. Cell Death & Disease. 12: 1008. PMID 34707106 DOI: 10.1038/s41419-021-04319-x |
0.324 |
|
| 2021 |
Wang P, Chen X, Wang Y, Jia C, Liu X, Wang Y, Wu H, Cai H, Shen HM, Le W. Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration. Cell Death & Disease. 12: 116. PMID 33483473 DOI: 10.1038/s41419-021-03412-5 |
0.328 |
|
| 2020 |
Jiao L, Zheng M, Duan J, Wu T, Li Z, Liu L, Xiang X, Tang X, He J, Li X, Zhang G, Ding J, Cai H, Lin X. Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 12239-12254. PMID 33000527 DOI: 10.1096/fj.202000017RR |
0.425 |
|
| 2020 |
Jia C, Qi H, Cheng C, Wu X, Yang Z, Cai H, Chen S, Le W. α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism. Frontiers in Molecular Neuroscience. 13: 64. PMID 32477062 DOI: 10.3389/fnmol.2020.00064 |
0.342 |
|
| 2020 |
Dong J, Liu X, Wang Y, Cai H, Le W. Nurr1 conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons. Glia. PMID 32181533 DOI: 10.1002/glia.23826 |
0.45 |
|
| 2020 |
Chen X, Xie C, Tian W, Sun L, Zheng W, Hawes S, Chang L, Kung J, Ding J, Chen S, Le W, Cai H. Correction to: Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. Molecular Neurodegeneration. 15: 22. PMID 32178708 DOI: 10.1186/s13024-020-00371-x |
0.344 |
|
| 2020 |
Chen X, Xie C, Tian W, Sun L, Wang Z, Hawes S, Chang L, Kung J, Ding J, Chen S, Le W, Cai H. Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. Molecular Neurodegeneration. 15: 12. PMID 32075681 DOI: 10.1186/s13024-020-00360-0 |
0.308 |
|
| 2019 |
Wu J, Kung J, Dong J, Chang L, Xie C, Habib A, Hawes S, Yang N, Chen V, Liu Z, Evans R, Liang B, Sun L, Ding J, Yu J, ... ... Cai H, et al. Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Reports. 28: 1167-1181.e7. PMID 31365862 DOI: 10.1016/J.Celrep.2019.06.095 |
0.364 |
|
| 2019 |
Sgobio C, Sun L, Ding J, Herms J, Lovinger DM, Cai H. Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice. Scientific Reports. 9: 4857. PMID 30890737 DOI: 10.1038/S41598-019-41091-7 |
0.342 |
|
| 2019 |
Pan J, Yu J, Sun L, Xie C, Chang L, Wu J, Hawes S, Saez-Atienzar S, Zheng W, Kung J, Ding J, Le W, Chen S, Cai H. ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling. Scientific Reports. 9: 3602. PMID 30837649 DOI: 10.1038/s41598-019-40326-x |
0.364 |
|
| 2018 |
Guo JF, Zhang L, Li K, Mei JP, Xue J, Chen J, Tang X, Shen L, Jiang H, Chen C, Guo H, Wu XL, Sun SL, Xu Q, Sun QY, ... ... Cai HB, et al. Coding mutations in contribute to Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348779 DOI: 10.1073/Pnas.1809969115 |
0.372 |
|
| 2018 |
Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-induced inflammation. Nature. PMID 30135585 DOI: 10.1038/S41586-018-0448-9 |
0.416 |
|
| 2018 |
Zhou FQ, Jiang J, Griffith CM, Patrylo PR, Cai H, Chu Y, Yan XX. Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques. Alzheimer's Research & Therapy. 10: 40. PMID 29690919 DOI: 10.1186/S13195-018-0370-2 |
0.378 |
|
| 2018 |
Yu J, Lai C, Shim H, Xie C, Sun L, Long CX, Ding J, Li Y, Cai H. Genetic ablation of dynactin p150in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice. Molecular Neurodegeneration. 13: 10. PMID 29490687 DOI: 10.1186/S13024-018-0242-Z |
0.58 |
|
| 2018 |
Cho HJ, Xie C, Cai H. AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression. Translational Neurodegeneration. 7: 1. PMID 29387348 DOI: 10.1186/s40035-018-0106-z |
0.374 |
|
| 2018 |
Zhou Q, Wang Y, Zhang J, Shao Y, Li S, Wang Y, Cai H, Feng Y, Le W. Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis. Scientific Reports. 8: 1668. PMID 29374221 DOI: 10.1038/s41598-018-19923-9 |
0.341 |
|
| 2018 |
Tang X, Jiao L, Zheng M, Yan Y, Nie Q, Wu T, Wan X, Zhang G, Li Y, Wu S, Jiang B, Cai H, Xu P, Duan J, Lin X. Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice. Neuroscience. PMID 29337233 DOI: 10.1016/j.neuroscience.2018.01.002 |
0.447 |
|
| 2017 |
Zhang F, Zhong R, Li S, Fu Z, Cheng C, Cai H, Le W. Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease Mice and Wild-Type Littermates. Frontiers in Aging Neuroscience. 9: 282. PMID 28890695 DOI: 10.3389/fnagi.2017.00282 |
0.483 |
|
| 2017 |
Song R, Li J, Zhang J, Wang L, Tong L, Wang P, Yang H, Wei Q, Cai H, Luo J. Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif. Biochimie. PMID 28890387 DOI: 10.1016/j.biochi.2017.09.002 |
0.438 |
|
| 2017 |
Sgobio C, Wu J, Zheng W, Chen X, Pan J, Salinas AG, Davis MI, Lovinger DM, Cai H. Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum. Scientific Reports. 7: 5283. PMID 28706191 DOI: 10.1038/s41598-017-05598-1 |
0.481 |
|
| 2017 |
Guo F, Liu X, Cai H, Le W. Autophagy in Neurodegenerative Diseases: Pathogenesis and Therapy. Brain Pathology (Zurich, Switzerland). PMID 28703923 DOI: 10.1111/bpa.12545 |
0.524 |
|
| 2017 |
Hu X, Hu ZL, Li Z, Ruan CS, Qiu WY, Pan A, Li CQ, Cai Y, Shen L, Chu Y, Tang BS, Cai H, Zhou XF, Ma C, Yan XX. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Frontiers in Neuroanatomy. 11: 45. PMID 28638323 DOI: 10.3389/Fnana.2017.00045 |
0.489 |
|
| 2017 |
Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin X. Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28424350 DOI: 10.1096/fj.201601303R |
0.543 |
|
| 2017 |
Dunn AR, Stout KA, Ozawa M, Lohr KM, Hoffman CA, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry N, Cai H, Caudle WM, Miller GW. Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28246328 DOI: 10.1073/Pnas.1616892114 |
0.558 |
|
| 2017 |
Ye X, Feng T, Tammineni P, Chang Q, Jeong YY, Margolis DJ, Cai H, Kusnecov A, Cai Q. Regulation of Synaptic Aβ Generation Through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28159908 DOI: 10.1523/Jneurosci.2851-16.2017 |
0.525 |
|
| 2017 |
Pan J, Cai H. Opioid system in L-DOPA-induced dyskinesia. Translational Neurodegeneration. 6: 1. PMID 28105331 DOI: 10.1186/s40035-017-0071-y |
0.466 |
|
| 2017 |
Bonilha VL, Bell BA, Rayborn ME, Samuels IS, King A, Hollyfield JG, Xie C, Cai H. Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress. Free Radical Biology & Medicine. PMID 28088625 DOI: 10.1016/j.freeradbiomed.2017.01.018 |
0.488 |
|
| 2016 |
Ma B, Xu L, Pan X, Sun L, Ding J, Xie C, Koliatsos VE, Cai H. LRRK2 Modulates Microglial Activity through Regulation of Chemokine (C-X3-C) Receptor 1 -mediated Signaling Pathways. Human Molecular Genetics. PMID 27378696 DOI: 10.1093/Hmg/Ddw194 |
0.684 |
|
| 2016 |
Xu J, Wu XS, Sheng J, Zhang Z, Yue HY, Sun L, Sgobio C, Lin X, Peng S, Jin Y, Gan L, Cai H, Wu LG. α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4408-14. PMID 27098685 DOI: 10.1523/Jneurosci.3627-15.2016 |
0.355 |
|
| 2015 |
Liu Z, Cai H, Dang Y, Qiu C, Wang J. Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review). Molecular Medicine Reports. PMID 26707080 DOI: 10.3892/mmr.2015.4714 |
0.367 |
|
| 2015 |
Sastry N, Zheng W, Liu G, Wang H, Chen X, Cai M, Contractor P, Sgobio C, Sun L, Xie C, Cai H. No apparent transmission of transgenic α-synuclein into nigrostriatal dopaminergic neurons in multiple mouse models. Translational Neurodegeneration. 4: 23. PMID 26635953 DOI: 10.1186/s40035-015-0046-9 |
0.441 |
|
| 2015 |
Kim E, Wang B, Sastry N, Nelson PT, Cai H, Liao FF. NEDD4-mediated HSF1 degradation underlies α-synucleinopathy. Human Molecular Genetics. PMID 26503960 DOI: 10.1093/Hmg/Ddv445 |
0.329 |
|
| 2015 |
Chen X, Xie C, Sun L, Ding J, Cai H. Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice. Plos One. 10: e0136612. PMID 26317866 DOI: 10.1371/journal.pone.0136612 |
0.354 |
|
| 2015 |
Bonilha VL, Bell BA, Rayborn ME, Yang X, Kaul C, Grossman GH, Samuels IS, Hollyfield JG, Xie C, Cai H, Shadrach KG. Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice. Experimental Eye Research. PMID 26215528 DOI: 10.1016/j.exer.2015.07.014 |
0.38 |
|
| 2015 |
Liu G, Sgobio C, Gu X, Sun L, Lin X, Yu J, Parisiadou L, Xie C, Sastry N, Ding J, Lohr KM, Miller GW, Mateo Y, Lovinger DM, Cai H. Selective Expression of Parkinson's disease-related Leucine-rich Repeat Kinase 2 G2019S Missense Mutation in Midbrain Dopaminergic Neurons Impairs Dopamine Release and Dopaminergic Gene Expression. Human Molecular Genetics. PMID 26123485 DOI: 10.1093/Hmg/Ddv249 |
0.766 |
|
| 2015 |
Wandu WS, Tan C, Ogbeifun O, Vistica BP, Shi G, Hinshaw SJ, Xie C, Chen X, Klinman DM, Cai H, Gery I. Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response. Plos One. 10: e0128906. PMID 26067490 DOI: 10.1371/journal.pone.0128906 |
0.349 |
|
| 2015 |
Chen Y, Zhang DQ, Liao Z, Wang B, Gong S, Wang C, Zhang MZ, Wang GH, Cai H, Liao FF, Xu JP. Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease. Molecular Neurodegeneration. 10: 4. PMID 26013581 DOI: 10.1186/1750-1326-10-4 |
0.375 |
|
| 2015 |
Xue ZQ, He ZW, Yu JJ, Cai Y, Qiu WY, Pan A, Gai WP, Cai H, Luo XG, Ma C, Yan XX. Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain. Bmc Neurology. 15: 71. PMID 25934480 DOI: 10.1186/S12883-015-0327-Z |
0.333 |
|
| 2015 |
Li JM, Cai Y, Liu F, Yang L, Hu X, Patrylo PR, Cai H, Luo XG, Xiao D, Yan XX. Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum. Oncotarget. 6: 10772-85. PMID 25871402 DOI: 10.18632/ONCOTARGET.3599 |
0.332 |
|
| 2014 |
Cai H, Liu G, Sun L, Ding J. Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease. Translational Neurodegeneration. 3: 27. PMID 25705376 DOI: 10.1186/2047-9158-3-27 |
0.422 |
|
| 2014 |
Sgobio C, Kupferschmidt DA, Cui G, Sun L, Li Z, Cai H, Lovinger DM. Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons. Plos One. 9: e111749. PMID 25360513 DOI: 10.1371/Journal.Pone.0111749 |
0.318 |
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| 2014 |
Cho HJ, Yu J, Xie C, Rudrabhatla P, Chen X, Wu J, Parisiadou L, Liu G, Sun L, Ma B, Ding J, Liu Z, Cai H. Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. The Embo Journal. 33: 2314-31. PMID 25201882 DOI: 10.15252/Embj.201487807 |
0.739 |
|
| 2014 |
Luo J, Sun L, Lin X, Liu G, Yu J, Parisiadou L, Xie C, Ding J, Cai H. A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons. Human Molecular Genetics. 23: 6567-74. PMID 25051958 DOI: 10.1093/Hmg/Ddu377 |
0.757 |
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| 2014 |
Liu G, Yu J, Ding J, Xie C, Sun L, Rudenko I, Zheng W, Sastry N, Luo J, Rudow G, Troncoso JC, Cai H. Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation. The Journal of Clinical Investigation. 124: 3032-46. PMID 24865427 DOI: 10.1172/Jci72176 |
0.448 |
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| 2014 |
Bonilha VL, Rayborn ME, Yang X, Xie C, Cai H. Oxidative stress regulation by DJ-1 in the retinal pigment epithelium. Advances in Experimental Medicine and Biology. 801: 649-54. PMID 24664754 DOI: 10.1007/978-1-4614-3209-8_81 |
0.312 |
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| 2014 |
Yang C, Wang H, Qiao T, Yang B, Aliaga L, Qiu L, Tan W, Salameh J, McKenna-Yasek DM, Smith T, Peng L, Moore MJ, Brown RH, Cai H, Xu Z. Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 111: E1121-9. PMID 24616503 DOI: 10.1073/Pnas.1322641111 |
0.426 |
|
| 2014 |
Parisiadou L, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nature Neuroscience. 17: 367-76. PMID 24464040 DOI: 10.1038/Nn.3636 |
0.75 |
|
| 2014 |
Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca RamÃrez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, et al. A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation. The Journal of Biological Chemistry. 289: 895-908. PMID 24275654 DOI: 10.1074/Jbc.M113.507913 |
0.376 |
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| 2014 |
Yan XX, Ma C, Gai WP, Cai H, Luo XG. Can BACE1 inhibition mitigate early axonal pathology in neurological diseases? Journal of Alzheimer's Disease : Jad. 38: 705-18. PMID 24081378 DOI: 10.3233/Jad-131400 |
0.323 |
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| 2014 |
Aliaga L, Lai C, Yu J, Chub N, Shim H, Sun L, Xie C, Yang WJ, Lin X, O'Donovan MJ, Cai H. Corrigendum to Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons [Human Molecular Genetics, 22, 21, (2013) 4293-4305] DOI: 10.1093/hmg/ddt279 Human Molecular Genetics. 23: 3069. DOI: 10.1093/Hmg/Ddu098 |
0.537 |
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| 2014 |
Parisiadou L, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu X, Lin X, Crowley NA, Lovinger DM, Cai H. Erratum: Corrigendum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity Nature Neuroscience. 17: 1287-1287. DOI: 10.1038/Nn0914-1287B |
0.705 |
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| 2013 |
Trabzuni D, Ryten M, Emmett W, Ramasamy A, Lackner KJ, Zeller T, Walker R, Smith C, Lewis PA, Mamais A, de Silva R, Vandrovcova J, Hernandez D, Nalls MA, ... ... Cai H, et al. Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. Plos One. 8: e70724. PMID 23967090 DOI: 10.1371/Journal.Pone.0070724 |
0.314 |
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| 2013 |
Aliaga L, Lai C, Yu J, Chub N, Shim H, Sun L, Xie C, Yang WJ, Lin X, O'Donovan MJ, Cai H. Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons. Human Molecular Genetics. 22: 4293-305. PMID 23771029 DOI: 10.1093/Hmg/Ddt279 |
0.58 |
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| 2013 |
Liu F, Xue ZQ, Deng SH, Kun X, Luo XG, Patrylo PR, Rose GM, Cai H, Struble RG, Cai Y, Yan XX. γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ. The European Journal of Neuroscience. 37: 1714-25. PMID 23432732 DOI: 10.1111/Ejn.12159 |
0.622 |
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| 2013 |
Hammer MB, Eleuch-Fayache G, Schottlaender LV, Nehdi H, Gibbs JR, Arepalli SK, Chong SB, Hernandez DG, Sailer A, Liu G, Mistry PK, Cai H, Shrader G, Sassi C, Bouhlal Y, et al. Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity. American Journal of Human Genetics. 92: 245-51. PMID 23332917 DOI: 10.1016/J.Ajhg.2012.12.012 |
0.322 |
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| 2013 |
Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, Sun L, Ma B, Ding J, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans JM, He P, Troncoso JC, ... ... Cai H, et al. MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. Human Molecular Genetics. 22: 608-20. PMID 23125283 DOI: 10.1093/Hmg/Dds470 |
0.731 |
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| 2013 |
Li JM, Xue ZQ, Deng SH, Luo XG, Patrylo PR, Rose GW, Cai H, Cai Y, Yan XX. Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury. Neurotoxicity Research. 24: 1-14. PMID 23055086 DOI: 10.1007/S12640-012-9355-2 |
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| 2012 |
Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, Laferla FM, Cai H, Rose GM, Patrylo PR. Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. Plos One. 7: e48782. PMID 23155407 DOI: 10.1371/Journal.Pone.0048782 |
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| 2012 |
Lin X, Parisiadou L, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, ... ... Cai H, et al. Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9248-64. PMID 22764233 DOI: 10.1523/Jneurosci.1731-12.2012 |
0.805 |
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| 2012 |
Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. Plos One. 7: e39132. PMID 22723946 DOI: 10.1371/Journal.Pone.0039132 |
0.307 |
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| 2012 |
Liu G, Aliaga L, Cai H. α-synuclein, LRRK2 and their interplay in Parkinson's disease. Future Neurology. 7: 145-153. PMID 22563296 DOI: 10.2217/fnl.12.2 |
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| 2012 |
Cai Y, Xue ZQ, Zhang XM, Li MB, Wang H, Luo XG, Cai H, Yan XX. An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation Neuroscience. 215: 160-173. PMID 22542680 DOI: 10.1016/j.neuroscience.2012.04.043 |
0.378 |
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| 2012 |
Yan XX, Cai Y, Zhang XM, Luo XG, Cai H, Rose GM, Patrylo PR. BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice. Experimental Neurology. 235: 228-37. PMID 22265658 DOI: 10.1016/J.Expneurol.2012.01.003 |
0.389 |
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| 2012 |
Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Molecular Neurodegeneration. 7: 2. PMID 22230652 DOI: 10.1186/1750-1326-7-2 |
0.323 |
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| 2012 |
Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX. BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology. Neurotoxicity Research. 21: 160-74. PMID 21725719 DOI: 10.1007/S12640-011-9256-9 |
0.62 |
|
| 2011 |
Imai Y, Venderova K, Park DS, Cai H, Schmidt E. Animal models of Parkinson's disease. Parkinson's Disease. 2011: 364328. PMID 22220287 DOI: 10.4061/2011/364328 |
0.408 |
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| 2011 |
Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nature Immunology. 12: 1063-70. PMID 21983832 DOI: 10.1038/Ni.2113 |
0.352 |
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| 2011 |
Cheng N, Cai H, Belluscio L. In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13699-704. PMID 21957232 DOI: 10.1523/JNEUROSCI.1714-11.2011 |
0.387 |
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| 2010 |
Parisiadou L, Cai H. LRRK2 function on actin and microtubule dynamics in Parkinson disease. Communicative & Integrative Biology. 3: 396-400. PMID 21057624 DOI: 10.4161/Cib.3.5.12286 |
0.738 |
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| 2010 |
Cai Y, Xiong K, Zhang XM, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Chu Y, Kordower JH, Yan XX. β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation. The European Journal of Neuroscience. 32: 1223-38. PMID 20726888 DOI: 10.1111/J.1460-9568.2010.07376.X |
0.638 |
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| 2010 |
Gu XL, Long CX, Sun L, Xie C, Lin X, Cai H. Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice. Molecular Brain. 3: 12. PMID 20409326 DOI: 10.1186/1756-6606-3-12 |
0.415 |
|
| 2010 |
Zhang XM, Xiong K, Cai Y, Cai H, Luo XG, Feng JC, Clough RW, Patrylo PR, Struble RG, Yan XX. Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex. The European Journal of Neuroscience. 31: 710-21. PMID 20384814 DOI: 10.1111/J.1460-9568.2010.07103.X |
0.662 |
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| 2010 |
Yoo MH, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL. Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. Antioxidants & Redox Signaling. 12: 819-27. PMID 19769463 DOI: 10.1089/Ars.2009.2891 |
0.306 |
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| 2009 |
Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. The European Journal of Neuroscience. 30: 2271-83. PMID 20092570 DOI: 10.1111/J.1460-9568.2009.07017.X |
0.638 |
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| 2009 |
Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, ... ... Cai H, et al. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 64: 807-27. PMID 20064389 DOI: 10.1016/J.Neuron.2009.11.006 |
0.773 |
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| 2009 |
Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H. Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13971-80. PMID 19890007 DOI: 10.1523/Jneurosci.3799-09.2009 |
0.738 |
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| 2009 |
Lai C, Xie C, Shim H, Chandran J, Howell BW, Cai H. Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin. Molecular Brain. 2: 23. PMID 19630956 DOI: 10.1186/1756-6606-2-23 |
0.789 |
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| 2008 |
Cai H, Shim H, Lai C, Xie C, Lin X, Yang WJ, Chandran J. ALS2/alsin knockout mice and motor neuron diseases. Neuro-Degenerative Diseases. 5: 359-66. PMID 18714162 DOI: 10.1159/000151295 |
0.797 |
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| 2008 |
van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, Beilina A, Gibbs JR, Ding J, Myers AJ, Zhan M, ... Cai H, et al. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 10244-9. PMID 18626009 DOI: 10.1073/Pnas.0708518105 |
0.737 |
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| 2008 |
Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, Moore DJ, Dawson TM, Dawson VL, Chiosis G, Cookson MR, ... Cai H, et al. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3384-91. PMID 18367605 DOI: 10.1523/Jneurosci.0185-08.2008 |
0.777 |
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| 2008 |
Wang Y, Chandran JS, Cai H, Mattson MP. DJ-1 is essential for long-term depression at hippocampal CA1 synapses. Neuromolecular Medicine. 10: 40-5. PMID 18246449 DOI: 10.1007/S12017-008-8023-4 |
0.772 |
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| 2008 |
Chandran JS, Lin X, Zapata A, Höke A, Shimoji M, Moore SO, Galloway MP, Laird FM, Wong PC, Price DL, Bailey KR, Crawley JN, Shippenberg T, Cai H. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiology of Disease. 29: 505-14. PMID 18187333 DOI: 10.1016/J.Nbd.2007.11.011 |
0.792 |
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| 2008 |
Wang L, Shim H, Xie C, Cai H. Activation of protein kinase C modulates BACE1-mediated beta-secretase activity. Neurobiology of Aging. 29: 357-67. PMID 17157415 DOI: 10.1016/J.Neurobiolaging.2006.11.001 |
0.484 |
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| 2008 |
Jellinger KA, Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M, Papapetropoulos S, Argyriou AA, Polychronopoulos P, Spyridonidis T, Gourzis P, Chroni E, Cai H, Shim H, et al. Contents Vol. 5, 2008 Neurodegenerative Diseases. 5. DOI: 10.1159/000155242 |
0.71 |
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| 2008 |
Jellinger KA, Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M, Papapetropoulos S, Argyriou AA, Polychronopoulos P, Spyridonidis T, Gourzis P, Chroni E, Cai H, Shim H, et al. Subject Index Vol. 5, 2008 Neurodegenerative Diseases. 5: 369-370. DOI: 10.1159/000155229 |
0.711 |
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| 2007 |
Lai C, Lin X, Chandran J, Shim H, Yang WJ, Cai H. The G59S mutation in p150(glued) causes dysfunction of dynactin in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13982-90. PMID 18094236 DOI: 10.1523/Jneurosci.4226-07.2007 |
0.791 |
|
| 2007 |
Chandran J, Ding J, Cai H. Alsin and the molecular pathways of amyotrophic lateral sclerosis. Molecular Neurobiology. 36: 224-31. PMID 17955197 DOI: 10.1007/S12035-007-0034-X |
0.761 |
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| 2007 |
van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, ... ... Cai H, et al. Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. Plos Genetics. 3: e108. PMID 17590087 DOI: 10.1371/Journal.Pgen.0030108 |
0.742 |
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| 2007 |
Xiong K, Cai H, Luo XG, Struble RG, Clough RW, Yan XX. Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina. Experimental Brain Research. 181: 435-46. PMID 17429617 DOI: 10.1007/s00221-007-0943-y |
0.618 |
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| 2007 |
Erie EA, Shim H, Smith AL, Lin X, Keyvanfar K, Xie C, Chen J, Cai H. Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function. Journal of Neuroimmunology. 182: 226-31. PMID 17156857 DOI: 10.1016/J.Jneuroim.2006.10.019 |
0.509 |
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| 2007 |
Lin X, Shim H, Cai H. Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice. Neurobiology of Aging. 28: 1628-30. PMID 16973244 DOI: 10.1016/J.Neurobiolaging.2006.07.014 |
0.577 |
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| 2006 |
Lai C, Xie C, McCormack SG, Chiang HC, Michalak MK, Lin X, Chandran J, Shim H, Shimoji M, Cookson MR, Huganir RL, Rothstein JD, Price DL, Wong PC, Martin LJ, ... ... Cai H, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11798-806. PMID 17093100 DOI: 10.1523/Jneurosci.2084-06.2006 |
0.786 |
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| 2006 |
Wang L, Shim H, Xie C, Cai H. P4-257: Activation of protein kinase C suppresses the β-secretase activity through regulation of the degradation and translocation of BACE1 Alzheimer's & Dementia. 2: S592-S592. DOI: 10.1016/J.Jalz.2006.05.1996 |
0.469 |
|
| 2005 |
Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11693-709. PMID 16354928 DOI: 10.1523/Jneurosci.2766-05.2005 |
0.747 |
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| 2005 |
Cai H, Lin X, Xie C, Laird FM, Lai C, Wen H, Chiang HC, Shim H, Farah MH, Hoke A, Price DL, Wong PC. Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7567-74. PMID 16107644 DOI: 10.1523/Jneurosci.1645-05.2005 |
0.746 |
|
| 2005 |
Leemput JVd, Chandran J, Knight M, Holtzclaw L, Scholz S, Cookson MR, Houlden H, Gwinn K, Fung P, Lin X, Hernandez DG, Simon-Sanchez J, Wood N, Rafferty I, Hardy J, ... ... Cai H, et al. Deletion at ITPR1 underlies ataxia in mice and humans (SCA15) Plos Genetics. DOI: 10.1371/Journal.Pgen.0030108.Eor |
0.727 |
|
| 2004 |
Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 101: 3632-7. PMID 14978286 DOI: 10.1073/pnas.0205689101 |
0.579 |
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| 2004 |
Cai H, Wen H, Laird FM, Chiang H, Xu G, Borchelt DR, Price DL, Wong PC. P1-222 Deletion of BACE1 prevents age-associated neuropathological abnormalities in mutant APP;PS1 mice Neurobiology of Aging. 25: S159. DOI: 10.1016/S0197-4580(04)80535-9 |
0.592 |
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| 2004 |
Laird FM, Savonenko AV, Melnikova T, Cai H, Borchelt DR, Price DL, Wong PC. P1-179 Age-associated memory deficits occurring in Bace1-deficient mice or APP;PS1 mice are restored in APP;PS1 mice lacking BACE1: a role for APP and BACE1 in cognition Neurobiology of Aging. 25: S146. DOI: 10.1016/S0197-4580(04)80492-5 |
0.591 |
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| 2004 |
Wong PC, Cai H, Laird FM, Savonenko AV, Melnikova T, Price DL, Borchelt DR, Xu G. S1-01-02 A role for APP and BACE1 in cognition Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80005-8 |
0.526 |
|
| 2003 |
Li T, Ma G, Cai H, Price DL, Wong PC. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3272-7. PMID 12716934 |
0.666 |
|
| 2003 |
Li T, Ma G, Cai H, Price DL, Wong PC. Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals The Journal of Neuroscience. 23: 3272-3277. DOI: 10.1523/Jneurosci.23-08-03272.2003 |
0.635 |
|
| 2002 |
Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered mouse models of neurodegenerative diseases. Nature Neuroscience. 5: 633-9. PMID 12085093 DOI: 10.1038/Nn0702-633 |
0.625 |
|
| 2001 |
Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics. Journal of Molecular Neuroscience : Mn. 17: 233-57. PMID 11816796 DOI: 10.1385/Jmn:17:2:233 |
0.604 |
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| 2001 |
Wong PC, Price DL, Cai H. The brain's susceptibility to amyloid plaques. Science (New York, N.Y.). 293: 1434. PMID 11526940 DOI: 10.1126/Science.293.5534.1434B |
0.569 |
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| 2001 |
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nature Neuroscience. 4: 233-4. PMID 11224536 DOI: 10.1038/85064 |
0.602 |
|
| 1999 |
Cai H, Reed RR. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6519-27. PMID 10414980 DOI: 10.1523/Jneurosci.19-15-06519.1999 |
0.551 |
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