Kathryn E. Saatman - Publications

Affiliations: 
University of Kentucky, Lexington, KY 

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Sama DM, Carlson SW, Joseph B, Saenger S, Metzger F, Saatman KE. Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury. Restorative Neurology and Neuroscience. PMID 29889090 DOI: 10.3233/RNN-180831  0.88
2018 DeWitt D, Hawkins BE, Dixon CE, Kochanek PM, Armstead WM, Bass C', Bramlett HM, Büki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds Ii CSR, LaPlaca M, Long J, ... ... Saatman KE, et al. Preclinical Testing of Therapies for Traumatic Brain Injury. Journal of Neurotrauma. PMID 29756522 DOI: 10.1089/neu.2018.5778  1
2018 Carlson SW, Saatman KE. Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function following Traumatic Brain Injury. Journal of Neurotrauma. PMID 29455576 DOI: 10.1089/neu.2017.5374  0.88
2017 Mir S, Cai W, Carlson SW, Saatman KE, Andres DA. IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade. Scientific Reports. 7: 3283. PMID 28607354 DOI: 10.1038/s41598-017-03641-9  0.88
2015 Muradashvili N, Benton RL, Saatman KE, Tyagi SC, Lominadze D. Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice. Metabolic Brain Disease. 30: 411-26. PMID 24771110 DOI: 10.1007/s11011-014-9550-3  1
2014 Bolton AN, Saatman KE. Regional neurodegeneration and gliosis are amplified by mild traumatic brain injury repeated at 24-hour intervals. Journal of Neuropathology and Experimental Neurology. 73: 933-47. PMID 25232942 DOI: 10.1097/NEN.0000000000000115  1
2014 Srodulski S, Sharma S, Bachstetter AB, Brelsfoard JM, Pascual C, Xie XS, Saatman KE, Van Eldik LJ, Despa F. Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin. Molecular Neurodegeneration. 9: 30. PMID 25149184 DOI: 10.1186/1750-1326-9-30  1
2014 Carlson SW, Madathil SK, Sama DM, Gao X, Chen J, Saatman KE. Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury. Journal of Neuropathology and Experimental Neurology. 73: 734-46. PMID 25003234 DOI: 10.1097/NEN.0000000000000092  1
2013 Madathil SK, Carlson SW, Brelsfoard JM, Ye P, D'Ercole AJ, Saatman KE. Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice. Plos One. 8: e67204. PMID 23826235 DOI: 10.1371/journal.pone.0067204  1
2013 Ma M, Ferguson TA, Schoch KM, Li J, Qian Y, Shofer FS, Saatman KE, Neumar RW. Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration. Neurobiology of Disease. 56: 34-46. PMID 23542511 DOI: 10.1016/j.nbd.2013.03.009  1
2013 Schoch KM, von Reyn CR, Bian J, Telling GC, Meaney DF, Saatman KE. Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse. Journal of Neurochemistry. 125: 909-20. PMID 23305291 DOI: 10.1111/jnc.12144  1
2012 Cai W, Carlson SW, Brelsfoard JM, Mannon CE, Moncman CL, Saatman KE, Andres DA. Rit GTPase signaling promotes immature hippocampal neuronal survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9887-97. PMID 22815504 DOI: 10.1523/JNEUROSCI.0375-12.2012  1
2012 Schoch KM, Evans HN, Brelsfoard JM, Madathil SK, Takano J, Saido TC, Saatman KE. Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Experimental Neurology. 236: 371-82. PMID 22572592 DOI: 10.1016/j.expneurol.2012.04.022  1
2012 Schoch KM, Madathil SK, Saatman KE. Genetic manipulation of cell death and neuroplasticity pathways in traumatic brain injury. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 323-37. PMID 22362424 DOI: 10.1007/s13311-012-0107-z  1
2012 Hunt RF, Haselhorst LA, Schoch KM, Bach EC, Rios-Pilier J, Scheff SW, Saatman KE, Smith BN. Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains. Epilepsy Research. 99: 167-70. PMID 22047981 DOI: 10.1016/j.eplepsyres.2011.10.011  1
2011 Pleasant JM, Carlson SW, Mao H, Scheff SW, Yang KH, Saatman KE. Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studies. Journal of Neurotrauma. 28: 2245-62. PMID 21341976 DOI: 10.1089/neu.2010.1499  1
2011 Madathil SK, Nelson PT, Saatman KE, Wilfred BR. MicroRNAs in CNS injury: potential roles and therapeutic implications. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 33: 21-6. PMID 21053309 DOI: 10.1002/bies.201000069  1
2010 Geddes JW, Saatman KE. Targeting individual calpain isoforms for neuroprotection. Experimental Neurology. 226: 6-7. PMID 20682310 DOI: 10.1016/j.expneurol.2010.07.025  1
2010 Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, Nelson PT. miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. The American Journal of Pathology. 177: 334-45. PMID 20489155 DOI: 10.2353/ajpath.2010.091202  1
2010 Saatman KE, Creed J, Raghupathi R. Calpain as a therapeutic target in traumatic brain injury. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 7: 31-42. PMID 20129495 DOI: 10.1016/j.nurt.2009.11.002  1
2010 Madathil SK, Evans HN, Saatman KE. Temporal and regional changes in IGF-1/IGF-1R signaling in the mouse brain after traumatic brain injury. Journal of Neurotrauma. 27: 95-107. PMID 19751099 DOI: 10.1089/neu.2009.1002  1
2009 Mbye LH, Singh IN, Carrico KM, Saatman KE, Hall ED. Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 87-97. PMID 18714331 DOI: 10.1038/jcbfm.2008.93  1
2008 Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT. Classification of traumatic brain injury for targeted therapies. Journal of Neurotrauma. 25: 719-38. PMID 18627252 DOI: 10.1089/neu.2008.0586  1
2007 Serbest G, Burkhardt MF, Siman R, Raghupathi R, Saatman KE. Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice. Neurochemical Research. 32: 2006-14. PMID 17401646 DOI: 10.1007/s11064-007-9318-9  1
2006 Lebesgue D, LeBold DG, Surles NO, Morales DM, Etgen AM, Zukin RS, Saatman KE. Effects of estradiol on cognition and hippocampal pathology after lateral fluid percussion brain injury in female rats. Journal of Neurotrauma. 23: 1814-27. PMID 17184191 DOI: 10.1089/neu.2006.23.1814  1
2006 Saatman KE, Feeko KJ, Pape RL, Raghupathi R. Differential behavioral and histopathological responses to graded cortical impact injury in mice. Journal of Neurotrauma. 23: 1241-53. PMID 16928182 DOI: 10.1089/neu.2006.23.1241  1
2006 Royo NC, Conte V, Saatman KE, Shimizu S, Belfield CM, Soltesz KM, Davis JE, Fujimoto ST, McIntosh TK. Hippocampal vulnerability following traumatic brain injury: a potential role for neurotrophin-4/5 in pyramidal cell neuroprotection. The European Journal of Neuroscience. 23: 1089-102. PMID 16553773 DOI: 10.1111/j.1460-9568.2006.04642.x  1
2005 Zhang C, Saatman KE, Royo NC, Soltesz KM, Millard M, Schouten JW, Motta M, Hoover RC, McMillan A, Watson DJ, Lee VM, Trojanowski JQ, McIntosh TK. Delayed transplantation of human neurons following brain injury in rats: a long-term graft survival and behavior study. Journal of Neurotrauma. 22: 1456-74. PMID 16379583 DOI: 10.1089/neu.2005.22.1456  1
2005 Emery DL, Fulp CT, Saatman KE, Schütz C, Neugebauer E, McIntosh TK. Newly born granule cells in the dentate gyrus rapidly extend axons into the hippocampal CA3 region following experimental brain injury. Journal of Neurotrauma. 22: 978-88. PMID 16156713 DOI: 10.1089/neu.2005.22.978  1
2005 Lenzlinger PM, Shimizu S, Marklund N, Thompson HJ, Schwab ME, Saatman KE, Hoover RC, Bareyre FM, Motta M, Luginbuhl A, Pape R, Clouse AK, Morganti-Kossmann C, McIntosh TK. Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats. Neuroscience. 134: 1047-56. PMID 15979242 DOI: 10.1016/j.neuroscience.2005.04.048  1
2005 Longhi L, Saatman KE, Fujimoto S, Raghupathi R, Meaney DF, Davis J, McMillan B S A, Conte V, Laurer HL, Stein S, Stocchetti N, McIntosh TK. Temporal window of vulnerability to repetitive experimental concussive brain injury. Neurosurgery. 56: 364-74; discussion 3. PMID 15670384 DOI: 10.1227/01.NEU.0000149008.73513.44  1
2005 Thompson HJ, Hoover RC, Tkacs NC, Saatman KE, McIntosh TK. Development of posttraumatic hyperthermia after traumatic brain injury in rats is associated with increased periventricular inflammation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 163-76. PMID 15647747 DOI: 10.1038/sj.jcbfm.9600008  1
2004 Longhi L, Watson DJ, Saatman KE, Thompson HJ, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski JQ, Lee VM, Wolfe JH, Stocchetti N, McIntosh TK. Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma. 21: 1723-36. PMID 15684764 DOI: 10.1089/neu.2004.21.1723  1
2004 Schouten JW, Fulp CT, Royo NC, Saatman KE, Watson DJ, Snyder EY, Trojanowski JQ, Prockop DJ, Maas AI, McIntosh TK. A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. Journal of Neurotrauma. 21: 1501-38. PMID 15684646 DOI: 10.1089/neu.2004.21.1501  1
2004 Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK. Motor and cognitive function evaluation following experimental traumatic brain injury. Neuroscience and Biobehavioral Reviews. 28: 365-78. PMID 15341032 DOI: 10.1016/j.neubiorev.2004.06.002  1
2004 Lenzlinger PM, Saatman KE, Hoover RC, Cheney JA, Bareyre FM, Raghupathi R, Arnold LD, McIntosh TK. Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats. Restorative Neurology and Neuroscience. 22: 73-9. PMID 15272142  1
2004 Hoover RC, Motta M, Davis J, Saatman KE, Fujimoto ST, Thompson HJ, Stover JF, Dichter MA, Twyman R, White HS, McIntosh TK. Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in rats. Journal of Neurotrauma. 21: 501-12. PMID 15165359 DOI: 10.1089/089771504774129847  1
2004 Wilson S, Raghupathi R, Saatman KE, MacKinnon MA, McIntosh TK, Graham DI. Continued in situ DNA fragmentation of microglia/macrophages in white matter weeks and months after traumatic brain injury. Journal of Neurotrauma. 21: 239-50. PMID 15115599 DOI: 10.1089/089771504322972031  1
2004 Marciano PG, Brettschneider J, Manduchi E, Davis JE, Eastman S, Raghupathi R, Saatman KE, Speed TP, Stoeckert CJ, Eberwine JH, McIntosh TK. Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2866-76. PMID 15044525 DOI: 10.1523/JNEUROSCI.5051-03.2004  1
2003 Emery DL, Royo NC, Fischer I, Saatman KE, McIntosh TK. Plasticity following injury to the adult central nervous system: is recapitulation of a developmental state worth promoting? Journal of Neurotrauma. 20: 1271-92. PMID 14748977 DOI: 10.1089/089771503322686085  1
2003 Uryu K, Giasson BI, Longhi L, Martinez D, Murray I, Conte V, Nakamura M, Saatman K, Talbot K, Horiguchi T, McIntosh T, Lee VM, Trojanowski JQ. Age-dependent synuclein pathology following traumatic brain injury in mice. Experimental Neurology. 184: 214-24. PMID 14637093 DOI: 10.1016/S0014-4886(03)00245-0  1
2003 Huh JW, Raghupathi R, Laurer HL, Helfaer MA, Saatman KE. Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in mice. Journal of Neurotrauma. 20: 975-84. PMID 14588114 DOI: 10.1089/089771503770195821  1
2003 Smith DH, Uryu K, Saatman KE, Trojanowski JQ, McIntosh TK. Protein accumulation in traumatic brain injury. Neuromolecular Medicine. 4: 59-72. PMID 14528053 DOI: 10.1385/NMM:4:1-2:59  1
2003 Denslow N, Michel ME, Temple MD, Hsu CY, Saatman K, Hayes RL. Application of proteomics technology to the field of neurotrauma Journal of Neurotrauma. 20: 401-407. PMID 12803973  1
2003 Thompson HJ, Tkacs NC, Saatman KE, Raghupathi R, McIntosh TK. Hyperthermia following traumatic brain injury: a critical evaluation. Neurobiology of Disease. 12: 163-73. PMID 12742737 DOI: 10.1016/S0969-9961(02)00030-X  1
2003 Lifshitz J, Friberg H, Neumar RW, Raghupathi R, Welsh FA, Janmey P, Saatman KE, Wieloch T, Grady MS, McIntosh TK. Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 219-31. PMID 12571453 DOI: 10.1097/01.WCB.0000040581.43808.03  1
2003 Saatman KE, Abai B, Grosvenor A, Vorwerk CK, Smith DH, Meaney DF. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 34-42. PMID 12500089  1
2003 Conte V, Royo NC, Shimizu S, Saatman KE, Watson DJ, Graham DI, Stocchetti N, McIntosh TK. Neurotrophic Factors: Pathophysiology and Therapeutic Applications in Traumatic Brain Injury European Journal of Trauma. 29: 335-355. DOI: 10.1007/s00068-003-1335-z  1
2002 Marciano PG, Eberwine JH, Ragupathi R, Saatman KE, Meaney DF, McIntosh TK. Expression profiling following traumatic brain injury: a review. Neurochemical Research. 27: 1147-55. PMID 12462413 DOI: 10.1023/A:1020973308941  1
2002 Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, Raghupathi R, Lenzlinger PM, Lifshitz J, Boockvar J, Neugebauer E, Snyder EY, McIntosh TK. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery. 51: 1043-52; discussion . PMID 12234415 DOI: 10.1097/00006123-200210000-00035  1
2002 Laurer HL, Ritting AN, Russ AB, Bareyre FM, Raghupathi R, Saatman KE. Effects of underwater sound exposure on neurological function and brain histology. Ultrasound in Medicine & Biology. 28: 965-73. PMID 12208341 DOI: 10.1016/S0301-5629(02)00526-4  1
2002 Fowler J, MacKinnon MA, Raghupathi R, Saatman KE, McIntosh TK, Graham DI. Age does not influence DNA fragmentation in the hippocampus after fatal traumatic brain injury in young and aged humans compared with controls. Clinical Neuropathology. 21: 156-62. PMID 12143927  1
2002 Huh JW, Laurer HL, Raghupathi R, Helfaer MA, Saatman KE. Rapid loss and partial recovery of neurofilament immunostaining following focal brain injury in mice. Experimental Neurology. 175: 198-208. PMID 12009772 DOI: 10.1006/exnr.2002.7880  1
2001 Williams S, Raghupathi R, MacKinnon MA, McIntosh TK, Saatman KE, Graham DI. In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man. Acta Neuropathologica. 102: 581-90. PMID 11761718  1
2001 Laurer HL, Bareyre FM, Lee VM, Trojanowski JQ, Longhi L, Hoover R, Saatman KE, Raghupathi R, Hoshino S, Grady MS, McIntosh TK. Mild head injury increasing the brain's vulnerability to a second concussive impact. Journal of Neurosurgery. 95: 859-70. PMID 11702878 DOI: 10.3171/jns.2001.95.5.0859  1
2001 Longhi L, Saatman KE, Raghupathi R, Laurer HL, Lenzlinger PM, Riess P, Neugebauer E, Trojanowski JQ, Lee VM, Grady MS, Graham DI, McIntosh TK. A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 21: 1241-58. PMID 11702040 DOI: 10.1097/00004647-200111000-00001  1
2001 Riess P, Bareyre FM, Saatman KE, Cheney JA, Lifshitz J, Raghupathi R, Grady MS, Neugebauer E, McIntosh TK. Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury. Restorative Neurology and Neuroscience. 18: 1-8. PMID 11673665  1
2001 Shaw K, MacKinnon MA, Raghupathi R, Saatman KE, Mclntosh TK, Graham DI. TUNEL-positive staining in white and grey matter after fatal head injury in man. Clinical Neuropathology. 20: 106-12. PMID 11430493  1
2001 Cheney JA, Weisser JD, Bareyre FM, Laurer HL, Saatman KE, Raghupathi R, Gribkoff V, Starrett JE, McIntosh TK. The maxi-K channel opener BMS-204352 attenuates regional cerebral edema and neurologic motor impairment after experimental brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 21: 396-403. PMID 11323525 DOI: 10.1097/00004647-200104000-00008  1
2001 Bareyre FM, Raghupathi R, Saatman KE, McIntosh TK. DNase I disinhibition is predominantly associated with actin hyperpolymerization after traumatic brain injury. Journal of Neurochemistry. 77: 173-81. PMID 11279273 DOI: 10.1046/j.1471-4159.2001.00215.x  1
2001 Saatman KE, Bareyre FM, Grady MS, McIntosh TK. Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency. Journal of Neuropathology and Experimental Neurology. 60: 183-94. PMID 11273006  1
2000 O'Dell DM, Muir JK, Zhang C, Bareyre FM, Saatman KE, Raghupathi R, Welsh F, McIntosh TK. Lubeluzole treatment does not attenuate neurobehavioral dysfunction or CA3 hippocampal neuronal loss following traumatic brain injury in rats. Restorative Neurology and Neuroscience. 16: 127-134. PMID 12671215  1
2000 Bareyre FM, Saatman KE, Raghupathi R, McIntosh TK. Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats. Journal of Neurotrauma. 17: 1029-39. PMID 11101206  1
2000 Smith FM, Raghupathi R, MacKinnon MA, McIntosh TK, Saatman KE, Meaney DF, Graham DI. TUNEL-positive staining of surface contusions after fatal head injury in man. Acta Neuropathologica. 100: 537-45. PMID 11045676 DOI: 10.1007/s004010000222  1
2000 Blaha GR, Raghupathi R, Saatman KE, McIntosh TK. Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits. Neuroscience. 99: 483-93. PMID 11029540 DOI: 10.1016/S0306-4522(00)00214-1  1
2000 Galvin JE, Nakamura M, McIntosh TK, Saatman KE, Sampathu D, Raghupathi R, Lee VM, Trojanowski JQ. Neurofilament-rich intraneuronal inclusions exacerbate neurodegenerative sequelae of brain trauma in NFH/LacZ transgenic mice. Experimental Neurology. 165: 77-89. PMID 10964487 DOI: 10.1006/exnr.2000.7461  1
2000 Emery DL, Raghupathi R, Saatman KE, Fischer I, Grady MS, McIntosh TK. Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma. The Journal of Comparative Neurology. 424: 521-31. PMID 10906717 DOI: 10.1002/1096-9861(20000828)424:3<521::AID-CNE9>3.0.CO;2-8  1
2000 Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VM, Trojanowski JQ. Brain trauma in aged transgenic mice induces regression of established abeta deposits. Experimental Neurology. 163: 244-52. PMID 10785464 DOI: 10.1006/exnr.2000.7375  1
2000 Cheney JA, Brown AL, Bareyre FM, Russ AB, Weisser JD, Ensinger HA, Leusch A, Raghupathi R, Saatman KE. The novel compound LOE 908 attenuates acute neuromotor dysfunction but not cognitive impairment or cortical tissue loss following traumatic brain injury in rats. Journal of Neurotrauma. 17: 83-91. PMID 10674760  1
2000 Graham DI, Raghupathi R, Saatman KE, Meaney D, McIntosh TK. Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury. Acta Neuropathologica. 99: 117-24. PMID 10672317  1
2000 Saatman KE, Zhang C, Bartus RT, McIntosh TK. Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 20: 66-73. PMID 10616794 DOI: 10.1097/00004647-200001000-00010  1
1999 Sanderson KL, Raghupathi R, Saatman KE, Martin D, Miller G, McIntosh TK. Interleukin-1 receptor antagonist attenuates regional neuronal cell death and cognitive dysfunction after experimental brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 1118-25. PMID 10532636 DOI: 10.1097/00004647-199910000-00008  1
1999 Zhang C, Raghupathi R, Saatman KE, LaPlaca MC, McIntosh TK. Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat. Journal of Neurochemistry. 73: 1650-9. PMID 10501212 DOI: 10.1046/j.1471-4159.1999.0731650.x  1
1999 Smith DH, Chen XH, Nonaka M, Trojanowski JQ, Lee VM, Saatman KE, Leoni MJ, Xu BN, Wolf JA, Meaney DF. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. Journal of Neuropathology and Experimental Neurology. 58: 982-92. PMID 10499440  1
1999 Nakamura M, Raghupathi R, Merry DE, Scherbel U, Saatman KE, Mcintosh TK. Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice. The Journal of Comparative Neurology. 412: 681-92. PMID 10464363 DOI: 10.1002/(SICI)1096-9861(19991004)412:4<681::AID-CNE9>3.0.CO;2-F  1
1999 Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VM, Trojanowski JQ. Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging. The Journal of Comparative Neurology. 411: 390-8. PMID 10413774 DOI: 10.1002/(SICI)1096-9861(19990830)411:3<390::AID-CNE3>3.0.CO;2-#  1
1999 Philips MF, Muir JK, Saatman KE, Raghupathi R, Lee VM, Trojanowski JQ, McIntosh TK. Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats. Journal of Neurosurgery. 90: 116-24. PMID 10413164 DOI: 10.3171/jns.1999.90.1.0116  1
1999 Nakamura M, Saatman KE, Galvin JE, Scherbel U, Raghupathi R, Trojanowski JQ, McIntosh TK. Increased vulnerability of NFH-LacZ transgenic mouse to traumatic brain injury-induced behavioral deficits and cortical damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 762-70. PMID 10413031 DOI: 10.1097/00004647-199907000-00006  1
1999 Scherbel U, Raghupathi R, Nakamura M, Saatman KE, Trojanowski JQ, Neugebauer E, Marino MW, McIntosh TK. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proceedings of the National Academy of Sciences of the United States of America. 96: 8721-6. PMID 10411942 DOI: 10.1073/pnas.96.15.8721  1
1999 Bareyre FM, Saatman KE, Helfaer MA, Sinson G, Weisser JD, Brown AL, McIntosh TK. Alterations in ionized and total blood magnesium after experimental traumatic brain injury: relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride. Journal of Neurochemistry. 73: 271-80. PMID 10386980 DOI: 10.1046/j.1471-4159.1999.0730271.x  1
1999 LaPlaca MC, Raghupathi R, Verma A, Pieper AA, Saatman KE, Snyder SH, McIntosh TK. Temporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat. Journal of Neurochemistry. 73: 205-13. PMID 10386972 DOI: 10.1046/j.1471-4159.1999.0730205.x  1
1999 Chen XH, Meaney DF, Xu BN, Nonaka M, McIntosh TK, Wolf JA, Saatman KE, Smith DH. Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig. Journal of Neuropathology and Experimental Neurology. 58: 588-96. PMID 10374749  1
1999 Muir JK, Raghupathi R, Saatman KE, Wilson CA, Lee VM, Trojanowski JQ, Philips MF, McIntosh TK. Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain. Journal of Neurotrauma. 16: 403-14. PMID 10369560  1
1999 Guluma KZ, Saatman KE, Brown A, Raghupathi R, McIntosh TK. Sequential pharmacotherapy with magnesium chloride and basic fibroblast growth factor after fluid percussion brain injury results in less neuromotor efficacy than that achieved with magnesium alone. Journal of Neurotrauma. 16: 311-21. PMID 10225217  1
1999 Steward O, Schauwecker PE, Guth L, Zhang Z, Fujiki M, Inman D, Wrathall J, Kempermann G, Gage FH, Saatman KE, Raghupathi R, McIntosh T. Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Experimental Neurology. 157: 19-42. PMID 10222106 DOI: 10.1006/exnr.1999.7040  1
1999 Huh J, Saatman KE, Raghupathi R, Laurer HL, Helfaer MA, McIntosh TK. Dephosphorylated neurofilaments are vulnerable following focal traumatic brain injury in mice Critical Care Medicine. 27: A59.  1
1998 Saatman KE, Graham DI, McIntosh TK. The neuronal cytoskeleton is at risk after mild and moderate brain injury. Journal of Neurotrauma. 15: 1047-58. PMID 9872461  1
1998 Morrison B, Saatman KE, Meaney DF, McIntosh TK. In vitro central nervous system models of mechanically induced trauma: a review. Journal of Neurotrauma. 15: 911-28. PMID 9840765  1
1998 McIntosh TK, Saatman KE, Raghupathi R, Graham DI, Smith DH, Lee VM, Trojanowski JQ. The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms. Neuropathology and Applied Neurobiology. 24: 251-67. PMID 9775390 DOI: 10.1046/j.1365-2990.1998.00121.x  1
1998 Smith DH, Nakamura M, McIntosh TK, Wang J, Rodríguez A, Chen XH, Raghupathi R, Saatman KE, Clemens J, Schmidt ML, Lee VM, Trojanowski JQ. Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein. The American Journal of Pathology. 153: 1005-10. PMID 9736050 DOI: 10.1016/S0002-9440(10)65643-X  1
1998 Zhang C, Raghupathi R, Saatman KE, Smith DH, Stutzmann JM, Wahl F, McIntosh TK. Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat. Journal of Neuroscience Research. 52: 342-9. PMID 9590442 DOI: 10.1002/(SICI)1097-4547(19980501)52:3<342::AID-JNR10>3.0.CO;2-8  1
1998 Murai H, Pierce JE, Raghupathi R, Smith DH, Saatman KE, Trojanowski JQ, Lee VM, Loring JF, Eckman C, Younkin S, McIntosh TK. Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury. The Journal of Comparative Neurology. 392: 428-38. PMID 9514508 DOI: 10.1002/(SICI)1096-9861(19980323)392:4<428::AID-CNE2>3.0.CO;2-2  1
1997 Saatman KE, Contreras PC, Smith DH, Raghupathi R, McDermott KL, Fernandez SC, Sanderson KL, Voddi M, McIntosh TK. Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury. Experimental Neurology. 147: 418-27. PMID 9344566 DOI: 10.1006/exnr.1997.6629  1
1997 Smith DH, Perri BR, Raghupathi R, Saatman KE, McIntosh TK. Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat. Neuroscience Letters. 231: 135-8. PMID 9300640 DOI: 10.1016/S0304-3940(97)00551-X  1
1997 McIntosh TK, Garde E, Saatman KE, Smith DH. Central nervous system resuscitation. Emergency Medicine Clinics of North America. 15: 527-50. PMID 9255131 DOI: 10.1016/S0733-8627(05)70316-3  1
1997 McDermott KL, Raghupathi R, Fernandez SC, Saatman KE, Protter AA, Finklestein SP, Sinson G, Smith DH, McIntosh TK. Delayed administration of basic fibroblast growth factor (bFGF) attenuates cognitive dysfunction following parasagittal fluid percussion brain injury in the rat. Journal of Neurotrauma. 14: 191-200. PMID 9151768  1
1997 Perri BR, Smith DH, Murai H, Sinson G, Saatman KE, Raghupathi R, Bartus RT, McIntosh TK. Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat. Journal of Neurotrauma. 14: 15-22. PMID 9048307  1
1997 Mcintosh TK, Saatman KE, Raghupathi R. Calcium and the pathogenesis of traumatic CNS injury: Cellular and molecular mechanisms Neuroscientist. 3: 169-175.  1
1996 Saatman KE, Bozyczko-Coyne D, Marcy V, Siman R, McIntosh TK. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat. Journal of Neuropathology and Experimental Neurology. 55: 850-60. PMID 8965100  1
1996 Saatman KE, Murai H, Bartus RT, Smith DH, Hayward NJ, Perri BR, McIntosh TK. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Proceedings of the National Academy of Sciences of the United States of America. 93: 3428-33. PMID 8622952 DOI: 10.1073/pnas.93.8.3428  1
1995 Smith DH, Soares HD, Pierce JS, Perlman KG, Saatman KE, Meaney DF, Dixon CE, McIntosh TK. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. Journal of Neurotrauma. 12: 169-78. PMID 7629863  1
1992 Saatman KE, Thibault LE, Meaney DF. Biomechanics of isolated myelinated nerve as related to brain injury American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 22: 549-552.  1
1989 Saatman KE, Thibault LE. Rapid elongation of a myelinated nerve fiber: A model for neural injury Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 11: 1663-1664.  1
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