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Steven G. Younkin, MD, University of Pennsylvania, PhD, University of Pennsylvania - Publications

Affiliations: 
Research Mayo Cllinic Jacksonville, Jacksonville, FL, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=35
Website:
http://mayoresearch.mayo.edu/mayo/research/staff/younkin_sg.cfm

200 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Younkin SG, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.4
2018 Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, ... ... Younkin SG, et al. TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease. The Journal of Experimental Medicine. PMID 30158114 DOI: 10.1084/jem.20180484  0.56
2018 Allen M, Wang X, Serie DJ, Strickland SL, Burgess JD, Koga S, Younkin CS, Nguyen TT, Malphrus KG, Lincoln SJ, Alamprese M, Zhu K, Chang R, Carrasquillo MM, Kouri N, ... ... Younkin SG, et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathologica. PMID 30136084 DOI: 10.1007/s00401-018-1900-5  0.56
2018 Ogaki K, Heckman MG, Koga S, Martens YA, Labbé C, Lorenzo-Betancor O, Walton RL, Soto AI, Vargas ER, Fujioka S, Uitti RJ, van Gerpen JA, Cheshire WP, Younkin SG, Wszolek ZK, et al. Association study between multiple system atrophy and TREM2 p.R47H. Neurology. Genetics. 4: e257. PMID 30109269 DOI: 10.1212/NXG.0000000000000257  0.36
2018 Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, et al. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimer's Research & Therapy. 10: 22. PMID 29458411 DOI: 10.1186/s13195-018-0349-z  0.56
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Younkin SG, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/s13073-018-0516-7  0.56
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Younkin SG, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/s13073-017-0486-1  0.56
2017 Allen M, Wang X, Burgess JD, Watzlawik J, Serie DJ, Younkin CS, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Ho C, Chakrabarty P, Strickland S, Murray ME, Swarup V, ... ... Younkin SG, et al. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29107053 DOI: 10.1016/j.jalz.2017.09.012  0.56
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Younkin SG, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/ng.3916  0.4
2017 Park L, Uekawa K, Garcia-Bonilla L, Koizumi K, Murphy M, Pitstick R, Younkin LH, Younkin SG, Zhou P, Carlson GA, Anrather J, Iadecola C. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circulation Research. PMID 28515043 DOI: 10.1161/CIRCRESAHA.117.311054  0.56
2017 N'Songo A, Carrasquillo MM, Wang X, Burgess JD, Nguyen T, Asmann YW, Serie DJ, Younkin SG, Allen M, Pedraza O, Duara R, Greig Custo MT, Graff-Radford NR, Ertekin-Taner N. African American exome sequencing identifies potential risk variants at Alzheimer disease loci. Neurology. Genetics. 3: e141. PMID 28480329 DOI: 10.1212/NXG.0000000000000141  0.4
2017 Zhao J, Davis MD, Atagi Y, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Human Molecular Genetics. PMID 28444230 DOI: 10.1093/hmg/ddx155  0.36
2017 Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, ... ... Younkin SG, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28183528 DOI: 10.1016/j.jalz.2016.12.012  0.4
2017 N'Songo A, Carrasquillo MM, Wang X, Nguyen T, Asmann Y, Younkin SG, Allen M, Duara R, Custo MT, Graff-Radford N, Ertekin-Taner N. Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants. Journal of Alzheimer's Disease : Jad. PMID 28106563 DOI: 10.3233/JAD-161185  0.4
2016 Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, ... ... Younkin SG, et al. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27939925 DOI: 10.1016/j.jalz.2016.10.005  0.56
2016 Ma L, Allen M, Sakae N, Ertekin-Taner N, Graff-Radford NR, Dickson DW, Younkin SG, Sevlever D. Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains. Molecular Neurodegeneration. 11: 72. PMID 27887626 DOI: 10.1186/s13024-016-0137-9  0.4
2016 Allen M, Carrasquillo MM, Funk C, Heavner BD, Zou F, Younkin CS, Burgess JD, Chai HS, Crook J, Eddy JA, Li H, Logsdon B, Peters MA, Dang KK, Wang X, ... ... Younkin SG, et al. Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases. Scientific Data. 3: 160089. PMID 27727239 DOI: 10.1038/sdata.2016.89  0.56
2016 Labbé C, Heckman MG, Lorenzo-Betancor O, Murray ME, Ogaki K, Soto-Ortolaza AI, Walton RL, Fujioka S, Koga S, Uitti RJ, van Gerpen JA, Petersen RC, Graff-Radford NR, Younkin SG, Boeve BF, et al. MAPT haplotype diversity in multiple system atrophy. Parkinsonism & Related Disorders. PMID 27374978 DOI: 10.1016/j.parkreldis.2016.06.010  0.36
2016 Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, ... ... Younkin SG, et al. Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 42. PMID 27216421 DOI: 10.1186/s13024-016-0105-4  0.36
2016 Allen M, Burgess JD, Ballard T, Serie D, Wang X, Younkin CS, Sun Z, Kouri N, Baheti S, Wang C, Carrasquillo MM, Nguyen T, Lincoln S, Malphrus K, Murray M, ... ... Younkin SG, et al. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci. Acta Neuropathologica. PMID 27115769 DOI: 10.1007/s00401-016-1576-7  0.36
2016 Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, ... ... Younkin SG, et al. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 31. PMID 27112350 DOI: 10.1186/s13024-016-0095-2  0.56
2016 Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, ... ... Younkin SG, et al. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3848-59. PMID 27030769 DOI: 10.1523/JNEUROSCI.3757-15.2016  0.36
2015 Allen M, Kachadoorian M, Carrasquillo MM, Karhade A, Manly L, Burgess JD, Wang C, Serie D, Wang X, Siuda J, Zou F, Chai HS, Younkin C, Crook J, Medway C, ... ... Younkin SG, et al. Late-onset Alzheimer disease risk variants mark brain regulatory loci. Neurology. Genetics. 1: e15. PMID 27066552 DOI: 10.1212/NXG.0000000000000012  0.4
2015 Carrasquillo MM, Barber I, Lincoln SJ, Murray ME, Camsari GB, Khan QU, Nguyen T, Ma L, Bisceglio GD, Crook JE, Younkin SG, Dickson DW, Boeve BF, Graff-Radford NR, Morgan K, et al. Evaluating pathogenic dementia variants in posterior cortical atrophy. Neurobiology of Aging. PMID 26507310 DOI: 10.1016/j.neurobiolaging.2015.09.023  0.4
2015 Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G. Apolipoprotein E is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of Biological Chemistry. PMID 26374899 DOI: 10.1074/jbc.M115.679043  0.56
2015 Santhanam AV, d'Uscio LV, He T, Das P, Younkin SG, Katusic ZS. Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice. Journal of Neurochemistry. PMID 26111938 DOI: 10.1111/jnc.13205  0.56
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Younkin SG, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/ncomms8247  0.56
2015 Malik M, Chiles J, Xi HS, Medway C, Simpson J, Potluri S, Howard D, Liang Y, Paumi CM, Mukherjee S, Crane P, Younkin S, Fardo DW, Estus S. Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia. Human Molecular Genetics. 24: 3557-70. PMID 25762156 DOI: 10.1093/hmg/ddv092  0.56
2015 Chouraki V, Beiser A, Younkin L, Preis SR, Weinstein G, Hansson O, Skoog I, Lambert JC, Au R, Launer L, Wolf PA, Younkin S, Seshadri S. Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 249-57.e1. PMID 25217292 DOI: 10.1016/j.jalz.2014.07.001  0.56
2015 Carrasquillo MM, Crook JE, Pedraza O, Thomas CS, Pankratz VS, Allen M, Nguyen T, Malphrus KG, Ma L, Bisceglio GD, Roberts RO, Lucas JA, Smith GE, Ivnik RJ, Machulda MM, ... ... Younkin SG, et al. Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease. Neurobiology of Aging. 36: 60-7. PMID 25189118 DOI: 10.1016/j.neurobiolaging.2014.07.042  0.56
2015 Braae A, Medway C, Carrasquillo M, Younkin S, Kehoe PG, Morgan K, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kölsch H, Vardy ERLC, Hooper NM, Mann DM, et al. Blood type gene locus has no influence on ACE association with Alzheimer's disease Neurobiology of Aging. 36: 1767.e1-1767.e2. DOI: 10.1016/j.neurobiolaging.2015.01.013  0.56
2014 Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HS, Younkin C, Crook JE, Pankratz VS, Carrasquillo MM, Krishnan S, Nguyen T, Ma L, Malphrus K, Lincoln S, Bisceglio G, ... ... Younkin SG, et al. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels. Alzheimer's Research & Therapy. 6: 39. PMID 25324900 DOI: 10.1186/alzrt268  0.56
2014 Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/journal.pgen.1004606  0.56
2014 De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, ... ... Younkin SG, et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nature Neuroscience. 17: 1156-63. PMID 25129075 DOI: 10.1038/nn.3786  0.36
2014 Carrasquillo MM, Khan Qu, Murray ME, Krishnan S, Aakre J, Pankratz VS, Nguyen T, Ma L, Bisceglio G, Petersen RC, Younkin SG, Dickson DW, Boeve BF, Graff-Radford NR, Ertekin-Taner N. Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. Neurology. 82: 1455-62. PMID 24670887 DOI: 10.1212/WNL.0000000000000335  0.56
2014 Medway CW, Abdul-Hay S, Mims T, Ma L, Bisceglio G, Zou F, Pankratz S, Sando SB, Aasly JO, Barcikowska M, Siuda J, Wszolek ZK, Ross OA, Carrasquillo M, Dickson DW, ... ... Younkin SG, et al. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Molecular Neurodegeneration. 9: 11. PMID 24607147 DOI: 10.1186/1750-1326-9-11  0.56
2014 Pedraza O, Allen M, Jennette K, Carrasquillo M, Crook J, Serie D, Pankratz VS, Palusak R, Nguyen T, Malphrus K, Ma L, Bisceglio G, Roberts RO, Lucas JA, Ivnik RJ, ... ... Younkin SG, et al. Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 205-13. PMID 23643458 DOI: 10.1016/j.jalz.2013.01.016  0.56
2014 Parikh I, Medway C, Younkin S, Fardo DW, Estus S. An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform Molecular Neurodegeneration. 9. DOI: 10.1186/1750-1326-9-32  0.56
2013 Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Josephs KA, Knopman DS, White CL, Caselli R, ... ... Younkin SG, et al. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Molecular Neurodegeneration. 8: 19. PMID 23800361 DOI: 10.1186/1750-1326-8-19  0.56
2013 Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, ... ... Younkin SG, et al. LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD). Plos One. 8: e64164. PMID 23750206 DOI: 10.1371/journal.pone.0064164  0.4
2013 Zou F, Belbin O, Carrasquillo MM, Culley OJ, Hunter TA, Ma L, Bisceglio GD, Allen M, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology. Plos One. 8: e64802. PMID 23724096 DOI: 10.1371/journal.pone.0064802  0.56
2013 Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, Iadecola C. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America. 110: 3089-94. PMID 23382216 DOI: 10.1073/pnas.1300021110  0.56
2013 Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1651-9. PMID 23345237 DOI: 10.1523/JNEUROSCI.3191-12.2013  0.56
2013 Tan WW, Heckman MG, Vishnu P, Crook JE, Younkin LH, Covil EG, Ferman TJ, Graff-Radford NR, Younkin SG, Smallridge RC, Wehle MJ, Buskirk SJ. Effect of leuprolide on serum amyloid-β peptide levels and memory in patients with prostate cancer with biochemical recurrence. Urology. 81: 150-4. PMID 23273081 DOI: 10.1016/j.urology.2012.08.066  0.56
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/NEJMoa1211851  0.56
2012 Wojtas A, Heggeli KA, Finch N, Baker M, Dejesus-Hernandez M, Younkin SG, Dickson DW, Graff-Radford NR, Rademakers R. C9ORF72 repeat expansions and other FTD gene mutations in a clinical AD patient series from Mayo Clinic. American Journal of Neurodegenerative Disease. 1: 107-18. PMID 23383383  0.36
2012 d'Uscio LV, Das P, Santhanam AV, He T, Younkin SG, Katusic ZS. Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. Cardiovascular Research. 96: 504-12. PMID 22886847 DOI: 10.1093/cvr/cvs266  0.56
2012 Rutherford NJ, Carrasquillo MM, Li M, Bisceglio G, Menke J, Josephs KA, Parisi JE, Petersen RC, Graff-Radford NR, Younkin SG, Dickson DW, Rademakers R. TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease. Neurology. 79: 717-8. PMID 22855871 DOI: 10.1212/WNL.0b013e318264e3ac  0.56
2012 Kamboh MI, Demirci FY, Wang X, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ, Jun G, Baldwin C, Logue MW, Buros J, Farrer L, Pericak-Vance MA, et al. Genome-wide association study of Alzheimer's disease. Translational Psychiatry. 2: e117. PMID 22832961 DOI: 10.1038/tp.2012.45  0.56
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Younkin SG, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/WNL.0b013e3182605801  0.56
2012 Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Younkin SG, et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. Plos Genetics. 8: e1002707. PMID 22685416 DOI: 10.1371/journal.pgen.1002707  0.56
2012 Allen M, Zou F, Chai HS, Younkin CS, Miles R, Nair AA, Crook JE, Pankratz VS, Carrasquillo MM, Rowley CN, Nguyen T, Ma L, Malphrus KG, Bisceglio G, Ortolaza AI, ... ... Younkin SG, et al. Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications. Molecular Neurodegeneration. 7: 13. PMID 22494505 DOI: 10.1186/1750-1326-7-13  0.56
2012 Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P, Morgan K. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging. 33: 1849.e5-18. PMID 22445811 DOI: 10.1016/j.neurobiolaging.2012.02.014  0.56
2012 Hamilton G, Killick R, Lambert JC, Amouyel P, Carrasquillo MM, Pankratz VS, Graff-Radford NR, Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging. 33: 1848.e1-13. PMID 22405046 DOI: 10.1016/j.neurobiolaging.2012.02.005  0.56
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Younkin SG, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/JAD-2011-110824  0.56
2012 Kamboh MI, Barmada MM, Demirci FY, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ, Sweet RA, Feingold E, DeKosky ST, Lopez OL. Genome-wide association analysis of age-at-onset in Alzheimer's disease. Molecular Psychiatry. 17: 1340-6. PMID 22005931 DOI: 10.1038/mp.2011.135  0.56
2012 Allen M, Cox C, Belbin O, Ma L, Bisceglio GD, Wilcox SL, Howell CC, Hunter TA, Culley O, Walker LP, Carrasquillo MM, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG, et al. Association and heterogeneity at the GAPDH locus in Alzheimer's disease. Neurobiology of Aging. 33: 203.e25-33. PMID 20864222 DOI: 10.1016/j.neurobiolaging.2010.08.002  0.56
2011 Simmons CR, Zou F, Younkin SG, Estus S. Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk. Molecular Neurodegeneration. 6: 62. PMID 21867541 DOI: 10.1186/1750-1326-6-62  0.56
2011 Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, ... ... Younkin SG, et al. Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study. Molecular Neurodegeneration. 6: 54. PMID 21798052 DOI: 10.1186/1750-1326-6-54  0.56
2011 Belbin O, Crump M, Bisceglio GD, Carrasquillo MM, Morgan K, Younkin SG. Multiple insulin degrading enzyme variants alter in vitro reporter gene expression. Plos One. 6: e21429. PMID 21731745 DOI: 10.1371/journal.pone.0021429  0.56
2011 Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, DeJesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, ... ... Younkin SG, et al. Ataxin-2 repeat-length variation and neurodegeneration. Human Molecular Genetics. 20: 3207-12. PMID 21610160 DOI: 10.1093/hmg/ddr227  0.56
2011 Simmons CR, Zou F, Younkin SG, Estus S. Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease. Molecular Neurodegeneration. 6: 33. PMID 21595938 DOI: 10.1186/1750-1326-6-33  0.56
2011 Turton JC, Bullock J, Medway C, Shi H, Brown K, Belbin O, Kalsheker N, Carrasquillo MM, Dickson DW, Graff-Radford NR, Petersen RC, Younkin SG, Morgan K. Investigating statistical epistasis in complex disorders. Journal of Alzheimer's Disease : Jad. 25: 635-44. PMID 21483092 DOI: 10.3233/JAD-2011-110197  0.56
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Younkin SG, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/ng.801  0.56
2011 Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proceedings of the National Academy of Sciences of the United States of America. 108: 5063-8. PMID 21383152 DOI: 10.1073/pnas.1015413108  0.56
2011 Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, ... ... Younkin SG, et al. Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions. Journal of Alzheimer's Disease : Jad. 24: 751-8. PMID 21321396 DOI: 10.3233/JAD-2011-101932  0.56
2011 Belbin O, Brown K, Shi H, Medway C, Abraham R, Passmore P, Mann D, Smith AD, Holmes C, McGuinness B, Craig D, Warden D, Heun R, Kölsch H, Love S, ... ... Younkin S, et al. A multi-center study of ACE and the risk of late-onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 587-97. PMID 21297258 DOI: 10.3233/JAD-2011-101914  0.56
2011 Yaffe K, Weston A, Graff-Radford NR, Satterfield S, Simonsick EM, Younkin SG, Younkin LH, Kuller L, Ayonayon HN, Ding J, Harris TB. Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline. Jama. 305: 261-6. PMID 21245181 DOI: 10.1001/jama.2010.1995  0.56
2011 Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, ... ... Younkin S, et al. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Archives of Neurology. 68: 99-106. PMID 21220680 DOI: 10.1001/archneurol.2010.346  0.56
2011 Burgess JD, Pedraza O, Graff-Radford NR, Hirpa M, Zou F, Miles R, Nguyen T, Li M, Lucas JA, Ivnik RJ, Crook J, Pankratz VS, Dickson DW, Petersen RC, Younkin SG, et al. Association of common KIBRA variants with episodic memory and AD risk. Neurobiology of Aging. 32: 557.e1-9. PMID 21185624 DOI: 10.1016/j.neurobiolaging.2010.11.004  0.56
2011 Finch N, Carrasquillo MM, Baker M, Rutherford NJ, Coppola G, Dejesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa KJ, Karydas AM, Sengdy P, ... ... Younkin SG, et al. TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology. 76: 467-74. PMID 21178100 DOI: 10.1212/WNL.0b013e31820a0e3b  0.56
2011 Belbin O, Carrasquillo MM, Crump M, Culley OJ, Hunter TA, Ma L, Bisceglio G, Zou F, Allen M, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease. Human Genetics. 129: 273-82. PMID 21132329 DOI: 10.1007/s00439-010-0924-2  0.56
2011 Alexander G, Hanna A, Serna V, Younkin L, Younkin S, Janus C. Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease Behavioural Brain Research. 216: 77-83. PMID 20655336 DOI: 10.1016/j.bbr.2010.07.016  0.56
2010 Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, ... ... Younkin SG, et al. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. American Journal of Human Genetics. 87: 890-7. PMID 21087763 DOI: 10.1016/j.ajhg.2010.11.002  0.56
2010 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Younkin SG, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/journal.pone.0013950  0.56
2010 Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Archives of Neurology. 67: 961-4. PMID 20554627 DOI: 10.1001/archneurol.2010.147  0.56
2010 Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT, ... ... Younkin SG, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. Jama. 303: 1832-40. PMID 20460622 DOI: 10.1001/jama.2010.574  0.56
2010 Zou F, Carrasquillo MM, Pankratz VS, Belbin O, Morgan K, Allen M, Wilcox SL, Ma L, Walker LP, Kouri N, Burgess JD, Younkin LH, Younkin SG, Younkin CS, Bisceglio GD, ... ... Younkin SG, et al. Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease. Neurology. 74: 480-6. PMID 20142614 DOI: 10.1212/WNL.0b013e3181d07654  0.56
2010 Carrasquillo MM, Belbin O, Zou F, Allen M, Ertekin-Taner N, Ansari M, Wilcox SL, Kashino MR, Ma L, Younkin LH, Younkin SG, Younkin CS, Dincman TA, Howard ME, Howell CC, ... ... Younkin SG, et al. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. Plos One. 5: e8764. PMID 20098734 DOI: 10.1371/journal.pone.0008764  0.56
2010 Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG. Genetic variation in PCDH11X is associated with susceptibility to late onset alzheimer's disease Hirosaki Medical Journal. 61: S125-S134.  0.56
2010 Younkin S. Current concepts in alzheimer's disease Hirosaki Medical Journal. 61: S97-S104.  0.56
2009 Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Molecular Neurodegeneration. 4: 46. PMID 19889229 DOI: 10.1186/1750-1326-4-46  0.56
2009 Verwey NA, van der Flier WM, Blennow K, Clark C, Sokolow S, De Deyn PP, Galasko D, Hampel H, Hartmann T, Kapaki E, Lannfelt L, Mehta PD, Parnetti L, Petzold A, Pirttila T, ... ... Younkin S, et al. A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease. Annals of Clinical Biochemistry. 46: 235-40. PMID 19342441 DOI: 10.1258/acb.2009.008232  0.56
2009 Finch N, Baker M, Crook R, Swanson K, Kuntz K, Surtees R, Bisceglio G, Rovelet-Lecrux A, Boeve B, Petersen RC, Dickson DW, Younkin SG, Deramecourt V, Crook J, Graff-Radford NR, et al. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Brain : a Journal of Neurology. 132: 583-91. PMID 19158106 DOI: 10.1093/brain/awn352  0.56
2009 Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, ... Younkin SG, et al. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. Nature Genetics. 41: 192-8. PMID 19136949 DOI: 10.1038/ng.305  0.56
2009 Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, Younkin S, Younkin L, Schiff R, Weksler ME. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiology of Aging. 30: 1728-36. PMID 18294736 DOI: 10.1016/j.neurobiolaging.2007.12.021  0.56
2008 Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, ... Younkin SG, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6030-6. PMID 18524908 DOI: 10.1523/JNEUROSCI.0891-08.2008  0.56
2008 Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 71: 85-92. PMID 18509095 DOI: 10.1212/01.wnl.0000303973.71803.81  0.56
2008 Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, et al. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain : a Journal of Neurology. 131: 651-64. PMID 18292081 DOI: 10.1093/brain/awn008  0.56
2008 Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 1347-52. PMID 18202172 DOI: 10.1073/pnas.0711568105  0.56
2008 Zou F, Gopalraj RK, Lok J, Zhu H, Ling IF, Simpson JF, Tucker HM, Kelly JF, Younkin SG, Dickson DW, Petersen RC, Graff-Radford NR, Bennett DA, Crook JE, Younkin SG, et al. Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease. Human Molecular Genetics. 17: 929-35. PMID 18065781 DOI: 10.1093/hmg/ddm365  0.56
2008 Ertekin-Taner N, Younkin LH, Yager DM, Parfitt F, Baker MC, Asthana S, Hutton ML, Younkin SG, Graff-Radford NR. Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. Neurology. 70: 596-606. PMID 17914065 DOI: 10.1212/01.WNL.0000278386.00035.21  0.56
2008 Zhu H, Taylor JW, Bennett DA, Younkin SG, Estus S. Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease. Neurobiology of Aging. 29: 793-4. PMID 17175070 DOI: 10.1016/j.neurobiolaging.2006.11.015  0.56
2007 Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. The Journal of Biological Chemistry. 282: 22707-20. PMID 17556372 DOI: 10.1074/jbc.M611050200  0.56
2007 Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 104: 8167-72. PMID 17470798 DOI: 10.1073/pnas.0609521104  0.56
2007 Graff-Radford NR, Crook JE, Lucas J, Boeve BF, Knopman DS, Ivnik RJ, Smith GE, Younkin LH, Petersen RC, Younkin SG. Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Archives of Neurology. 64: 354-62. PMID 17353377 DOI: 10.1001/archneur.64.3.354  0.56
2007 Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, ... ... Younkin S, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nature Genetics. 39: 168-77. PMID 17220890 DOI: 10.1038/ng1943  0.56
2006 Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M. Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neuroscience Letters. 395: 37-41. PMID 16298484 DOI: 10.1016/j.neulet.2005.10.087  0.56
2006 Elesber AA, Bonetti PO, Woodrum JE, Zhu XY, Lerman LO, Younkin SG, Lerman A. Bosentan preserves endothelial function in mice overexpressing APP. Neurobiology of Aging. 27: 446-50. PMID 15894408 DOI: 10.1016/j.neurobiolaging.2005.02.012  0.56
2005 Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. Plos Medicine. 2: e355. PMID 16279840 DOI: 10.1371/journal.pmed.0020355  0.56
2005 Rees TM, Berson A, Sklan EH, Younkin L, Younkin S, Brimijoin S, Soreq H. Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Current Alzheimer Research. 2: 291-300. PMID 15974894 DOI: 10.2174/1567205054367847  0.56
2005 Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5217-24. PMID 15917461 DOI: 10.1523/JNEUROSCI.5080-04.2005  0.56
2005 Wang DS, Lipton RB, Katz MJ, Davies P, Buschke H, Kuslansky G, Verghese J, Younkin SG, Eckman C, Dickson DW. Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. Journal of Neuropathology and Experimental Neurology. 64: 378-85. PMID 15892294  0.56
2005 Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1769-77. PMID 15716413 DOI: 10.1523/JNEUROSCI.5207-04.2005  0.56
2005 Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, ... ... Younkin SG, et al. Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Human Molecular Genetics. 14: 447-60. PMID 15615772 DOI: 10.1093/hmg/ddi041  0.56
2004 Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT. Altered amyloid-β metabolism and deposition in genomic-based β-secretaee transgenic mice Journal of Biological Chemistry. 279: 52535-52542. PMID 15452128 DOI: 10.1074/jbc.M409680200  0.56
2004 Tucker HM, Simpson J, Kihiko-Ehmann M, Younkin LH, McGillis JP, Younkin SG, Degen JL, Estus S. Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neuroscience Letters. 368: 285-9. PMID 15364412 DOI: 10.1016/j.neulet.2004.07.011  0.56
2004 Krezowski J, Knudson D, Ebeling C, Pitstick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Human Molecular Genetics. 13: 1989-97. PMID 15254013 DOI: 10.1093/hmg/ddh210  0.56
2004 Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Experimental Neurology. 188: 224-37. PMID 15246822 DOI: 10.1016/j.expneurol.2004.04.002  0.56
2004 Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG. Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3801-9. PMID 15084661 DOI: 10.1523/JNEUROSCI.5543-03.2004  0.56
2004 Ertekin-Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen RC, Graff-Radford N, Younkin SG. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Human Mutation. 23: 334-42. PMID 15024728 DOI: 10.1002/humu.20016  0.56
2004 Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Maruyama Y, Shoji M. Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiology of Aging. 25: 483-90. PMID 15013569 DOI: 10.1016/S0197-4580(03)00122-2  0.56
2004 Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 41: 27-33. PMID 14715132 DOI: 10.1016/S0896-6273(03)00810-9  0.56
2004 Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Human Molecular Genetics. 13: 159-70. PMID 14645205 DOI: 10.1093/hmg/ddh019  0.56
2003 Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Human Molecular Genetics. 12: 2949-56. PMID 14506131 DOI: 10.1093/hmg/ddg322  0.56
2002 Arvanitakis Z, Lucas JA, Younkin LH, Younkin SG, Graff-Radford NR. Serum creatinine levels correlate with plasma amyloid Beta protein. Alzheimer Disease and Associated Disorders. 16: 187-90. PMID 12218650 DOI: 10.1097/00002093-200207000-00009  0.56
2002 Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. American Journal of Physiology. Heart and Circulatory Physiology. 283: H315-23. PMID 12063304 DOI: 10.1152/ajpheart.00022.2002  0.56
2002 Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of Disease. 9: 269-73. PMID 11895378 DOI: 10.1006/nbdi.2001.0473  0.56
2002 Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1858-67. PMID 11880515  0.56
2002 Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiology of Disease. 9: 61-8. PMID 11848685 DOI: 10.1006/nbdi.2001.0460  0.56
2002 Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiology of Disease. 9: 11-23. PMID 11848681 DOI: 10.1006/nbdi.2001.0470  0.56
2001 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiology of Aging. 22: 721-7. PMID 11705631 DOI: 10.1016/S0197-4580(01)00245-7  0.56
2001 Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nature Neuroscience. 4: 887-93. PMID 11528419 DOI: 10.1038/nn0901-887  0.56
2001 Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M. Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. The Journal of Pathology. 194: 500-6. PMID 11523060 DOI: 10.1002/path.897  0.56
2001 Haugabook SJ, Yager DM, Eckman EA, Golde TE, Younkin SG, Eckman CB. High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta). Journal of Neuroscience Methods. 108: 171-9. PMID 11478976 DOI: 10.1016/S0165-0270(01)00388-0  0.56
2001 Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Adamson J, Schaid DJ, Blangero J, Hutton M, Younkin SG. Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees. Genetic Epidemiology. 21: 19-30. PMID 11443731 DOI: 10.1002/gepi.1015  0.56
2001 Golde TE, Younkin SG. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends in Molecular Medicine. 7: 264-9. PMID 11378516 DOI: 10.1016/S1471-4914(01)02064-0  0.56
2001 Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 372-81. PMID 11160418  0.56
2001 Younkin SG. Amyloid beta vaccination: reduced plaques and improved cognition. Nature Medicine. 7: 18-9. PMID 11135604 DOI: 10.1038/83292  0.56
2001 Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, et al. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 16-18. PMID 11099491 DOI: 10.1096/fj.00-0528fje  0.56
2000 Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science (New York, N.Y.). 290: 2303-4. PMID 11125143 DOI: 10.1126/science.290.5500.2303  0.56
2000 Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochemical and Biophysical Research Communications. 276: 422-7. PMID 11027491 DOI: 10.1006/bbrc.2000.3490  0.56
2000 Fagan AM, Younkin LH, Morris JC, Fryer JD, Cole TG, Younkin SG, Holtzman DM. Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype. Annals of Neurology. 48: 201-10. PMID 10939571 DOI: 10.1002/1531-8249(200008)48:2<201::AID-ANA10>3.0.CO;2-X  0.56
2000 Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochimica Et Biophysica Acta. 1502: 172-87. PMID 10899442 DOI: 10.1016/S0925-4439(00)00043-0  0.56
2000 Greenberg SM, Cho HS, O'Donnell HC, Rosand J, Segal AZ, Younkin LH, Younkin SG, Rebeck GW. Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy. Annals of the New York Academy of Sciences. 903: 144-9. PMID 10818500  0.56
2000 Younkin SG, Stoddard S. Mayo and the mouse. Nature. 404: 809. PMID 10786769 DOI: 10.1038/35009257  0.56
2000 Ohyagi Y, Yamada T, Nishioka K, Clarke NJ, Tomlinson AJ, Naylor S, Nakabeppu Y, Kira J, Younkin SG. Selective increase in cellular A beta 42 is related to apoptosis but not necrosis. Neuroreport. 11: 167-71. PMID 10683851  0.56
1999 Benzing WC, Wujek JR, Ward EK, Shaffer D, Ashe KH, Younkin SG, Brunden KR. Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice. Neurobiology of Aging. 20: 581-9. PMID 10674423 DOI: 10.1016/S0197-4580(99)00065-2  0.56
1999 Refolo LM, Eckman C, Prada CM, Yager D, Sambamurti K, Mehta N, Hardy J, Younkin SG. Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells. Journal of Neurochemistry. 73: 2383-8. PMID 10582597 DOI: 10.1046/j.1471-4159.1999.0732383.x  0.56
1999 Sambamurti K, Sevlever D, Koothan T, Refolo LM, Pinnix I, Gandhi S, Onstead L, Younkin L, Prada CM, Yager D, Ohyagi Y, Eckman CB, Rosenberry TL, Younkin SG. Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. The Journal of Biological Chemistry. 274: 26810-4. PMID 10480887 DOI: 10.1074/jbc.274.38.26810  0.56
1999 Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature Neuroscience. 2: 271-6. PMID 10195221 DOI: 10.1038/6374  0.56
1998 Younkin SG. The role of A beta 42 in Alzheimer's disease. Journal of Physiology, Paris. 92: 289-92. PMID 9789825 DOI: 10.1016/S0928-4257(98)80035-1  0.56
1998 Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiology of Disease. 5: 107-16. PMID 9746908 DOI: 10.1006/nbdi.1998.0183  0.56
1997 Younkin SG. The AAP and PS1/2 mutations linked to early onset familial Alzheimer's disease increase the extracellular concentration and A beta 1-42 (43). Rinshō Shinkeigaku = Clinical Neurology. 37: 1099. PMID 9577655  0.56
1997 Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J. A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43). Human Molecular Genetics. 6: 2087-9. PMID 9328472 DOI: 10.1093/hmg/6.12.2087  0.56
1997 McPhie DL, Lee RK, Eckman CB, Olstein DH, Durham SP, Yager D, Younkin SG, Wurtman RJ, Neve RL. Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains. The Journal of Biological Chemistry. 272: 24743-6. PMID 9312066 DOI: 10.1074/jbc.272.40.24743  0.56
1997 Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Human Molecular Genetics. 6: 1951-9. PMID 9302276 DOI: 10.1093/hmg/6.11.1951  0.56
1997 Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Human Molecular Genetics. 6: 1535-41. PMID 9285791 DOI: 10.1093/hmg/6.9.1535  0.56
1996 Ho L, Fukuchi Ki, Younkin SG. The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells. The Journal of Biological Chemistry. 271: 30929-34. PMID 8940079 DOI: 10.1074/jbc.271.48.30929  0.56
1996 Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, ... ... Younkin SG, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5  0.56
1996 Kawarabayashi T, Shoji M, Sato M, Sasaki A, Ho L, Eckman CB, Prada CM, Younkin SG, Kobayashi T, Tada N, Matsubara E, Iizuka T, Harigaya Y, Kasai K, Hirai S. Accumulation of beta-amyloid fibrils in pancreas of transgenic mice. Neurobiology of Aging. 17: 215-22. PMID 8744402 DOI: 10.1016/0197-4580(95)02061-6  0.56
1996 Turner RS, Suzuki N, Chyung AS, Younkin SG, Lee VM. Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation. The Journal of Biological Chemistry. 271: 8966-70. PMID 8621541  0.56
1995 Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiology of Disease. 2: 177-87. PMID 9174001 DOI: 10.1006/nbdi.1995.0019  0.56
1995 Shaffer LM, Dority MD, Gupta-Bansal R, Frederickson RC, Younkin SG, Brunden KR. Amyloid beta protein (A beta) removal by neuroglial cells in culture. Neurobiology of Aging. 16: 737-45. PMID 8532106 DOI: 10.1016/0197-4580(95)00055-J  0.56
1995 Gravina SA, Ho L, Eckman CB, Long KE, Otvos L, Younkin LH, Suzuki N, Younkin SG. Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). The Journal of Biological Chemistry. 270: 7013-6. PMID 7706234  0.56
1995 Younkin SG. Evidence that A beta 42 is the real culprit in Alzheimer's disease. Annals of Neurology. 37: 287-8. PMID 7695227 DOI: 10.1002/ana.410370303  0.56
1994 Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Eckman C, Golde TE, Younkin SG. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (New York, N.Y.). 264: 1336-40. PMID 8191290  0.56
1994 Nakamura T, Shoji M, Harigaya Y, Watanabe M, Hosoda K, Cheung TT, Shaffer LM, Golde TE, Younkin LH, Younkin SG. Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease. Annals of Neurology. 36: 903-11. PMID 7998778 DOI: 10.1002/ana.410360616  0.56
1994 Younkin SG. The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition. The Tohoku Journal of Experimental Medicine. 174: 217-23. PMID 7761987  0.56
1993 Cai XD, Golde TE, Younkin SG. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science (New York, N.Y.). 259: 514-6. PMID 8424174  0.56
1993 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proceedings of the National Academy of Sciences of the United States of America. 90: 9513-7. PMID 8415732  0.56
1993 Golde TE, Cai XD, Shoji M, Younkin SG. Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 103-8. PMID 8239266 DOI: 10.1111/j.1749-6632.1993.tb23036.x  0.56
1992 Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (New York, N.Y.). 255: 728-30. PMID 1738847  0.56
1992 Estus S, Golde TE, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu XM, Tabira T, Greenberg BD. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science (New York, N.Y.). 255: 726-8. PMID 1738846  0.56
1992 Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai XD, McKay DM, Tintner R, Frangione B. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (New York, N.Y.). 258: 126-9. PMID 1439760  0.56
1992 Pasternack JM, Palmert MR, Usiak M, Wang R, Zurcher-Neely H, Gonzalez-De Whitt PA, Fairbanks MB, Cheung T, Blades D, Heinrikson RL. Alzheimer's disease and control brain contain soluble derivatives of the amyloid protein precursor that end within the beta amyloid protein region. Biochemistry. 31: 10936-40. PMID 1420205  0.56
1992 Gillespie SL, Golde TE, Younkin SG. Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. Biochemical and Biophysical Research Communications. 187: 1285-90. PMID 1417805 DOI: 10.1016/0006-291X(92)90442-N  0.56
1992 Estus S, Golde TE, Younkin SG. Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives. Annals of the New York Academy of Sciences. 674: 138-48. PMID 1288359  0.56
1991 Lowery DE, Pasternack JM, Gonzalez-DeWhitt PA, Zürcher-Neely H, Tomich CC, Altman RA, Fairbanks MB, Heinrikson RL, Younkin SG, Greenberg BD. Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties. The Journal of Biological Chemistry. 266: 19842-50. PMID 1918088  0.56
1991 Kalaria RN, Golde TE, Cohen ML, Younkin SG. Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier. Annals of the New York Academy of Sciences. 640: 145-8. PMID 1776732  0.56
1991 Younkin SG. Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP). Brain Pathology (Zurich, Switzerland). 1: 253-62. PMID 1669715  0.56
1990 Podlisny MB, Mammen AL, Schlossmacher MG, Palmert MR, Younkin SG, Selkoe DJ. Detection of soluble forms of the beta-amyloid precursor protein in human plasma. Biochemical and Biophysical Research Communications. 167: 1094-101. PMID 2138892 DOI: 10.1016/0006-291X(90)90635-Z  0.56
1990 Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtellotte WW, Younkin SG. Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology. 40: 1028-34. PMID 2113204  0.56
1990 Golde TE, Estus S, Usiak M, Younkin LH, Younkin SG. Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron. 4: 253-67. PMID 2106330 DOI: 10.1016/0896-6273(90)90100-T  0.56
1990 Golde TE, Palmert MR, Estus S, Usiak M, Siedlak SL, Perry G, Younkin LH, Younkin SG. The β amyloid protein precursor: Analysis of mRNAs in ad and control brains and of soluble derivatives in human cerebrospinal fluid Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium On Dementia: Molecular Biology and Genetics of Alzheimer's Disease. Ics884. 137-147.  0.56
1989 Pasternack JM, Abraham CR, Van Dyke BJ, Potter H, Younkin SG. Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. The American Journal of Pathology. 135: 827-34. PMID 2817081  0.56
1989 Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proceedings of the National Academy of Sciences of the United States of America. 86: 6338-42. PMID 2503832  0.56
1989 Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG. Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochemical and Biophysical Research Communications. 165: 182-8. PMID 2480122 DOI: 10.1016/0006-291X(89)91052-8  0.56
1988 Younkin LH, McTiernan CF, Younkin SG. Effect of fibrillation on acetylcholinesterase mRNA in cultured embryonic rat myotubes. Experimental Cell Research. 174: 279-81. PMID 3335227 DOI: 10.1016/0014-4827(88)90161-9  0.56
1988 Cohen ML, Golde TE, Usiak MF, Younkin LH, Younkin SG. In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 85: 1227-31. PMID 3277188  0.56
1988 Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques. Biochemical and Biophysical Research Communications. 156: 432-7. PMID 3140814 DOI: 10.1016/S0006-291X(88)80859-3  0.56
1988 Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (New York, N.Y.). 241: 1080-4. PMID 2457949  0.56
1986 Brockman SK, Usiak MF, Younkin SG. Assembly of monomeric acetylcholinesterase into tetrameric and asymmetric forms. The Journal of Biological Chemistry. 261: 1201-7. PMID 3944084  0.56
1986 Brockman SK, Younkin SG. Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes. Brain Research. 376: 409-11. PMID 3730845 DOI: 10.1016/0006-8993(86)90210-6  0.56
1986 Younkin SG, Goodridge B, Katz J, Lockett G, Nafziger D, Usiak MF, Younkin LH. Molecular forms of acetylcholinesterases in Alzheimer's disease. Federation Proceedings. 45: 2982-8. PMID 2430839  0.56
1984 Newman JR, Virgin JB, Younkin LH, Younkin SG. Turnover of acetylcholinesterase in innervated and denervated rat diaphragm. The Journal of Physiology. 352: 305-18. PMID 6747890 DOI: 10.1113/jphysiol.1984.sp015292  0.56
1984 Brockman SK, Younkin LH, Younkin SG. The effect of spontaneous electromechanical activity on the metabolism of acetylcholinesterase in cultured embryonic rat myotubes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 131-40. PMID 6693937  0.56
1984 Lavin PJM, Younkin SG, Kori SH. The pathology of ophthalmoplegia in herpes zoster ophthalmicus Neuro-Ophthalmology. 4: 75-80. DOI: 10.3109/01658108409053863  0.56
1982 Brockman SK, Przybylski RJ, Younkin SG. Cellular localization of the molecular forms of acetylcholinesterase in cultured embryonic rat myotubes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 1775-85. PMID 7143051  0.56
1982 Collins PL, Younkin SG. Effect of denervation on the molecular forms of acetylcholinesterase in rat diaphragm. The Journal of Biological Chemistry. 257: 13638-44. PMID 7142170  0.56
1982 Younkin SG, Rosenstein C, Collins PL, Rosenberry TL. Cellular localization of the molecular forms of acetylcholinesterase in rat diaphragm. The Journal of Biological Chemistry. 257: 13630-7. PMID 7142169  0.56
1982 Younkin SG, Younkin LH, Zoller M, Rosenstein C. Partial purification by vacuum distillation of a factor that increases the junctional acetylcholinesterase of organ cultured rat diaphragm. Brain Research. 249: 192-4. PMID 7139295 DOI: 10.1016/0006-8993(82)90188-3  0.56
1982 Brett RS, Younkin SG, Konieczkowski M, Slugg RM. Accelerated degradation of junctional acetylcholine receptor-alpha-bungarotoxin complexes in denervated rat diaphragm. Brain Research. 233: 133-42. PMID 7059796 DOI: 10.1016/0006-8993(82)90935-0  0.56
1979 Davey B, Younkin LH, Younkin SG. Neural control of skeletal muscle cholinesterase: a study using organ-cultured rat muscle. The Journal of Physiology. 289: 501-15. PMID 88516  0.56
1978 DeCoursey TE, Younkin SG, Bryant SH. Neural control of chloride conductance in rat extensor digitorum longus muscle. Experimental Neurology. 61: 705-9. PMID 710575 DOI: 10.1016/0014-4886(78)90034-1  0.56
1978 Davey B, Younkin SG. Effect of nerve stump length on cholinesterase in denervated rat diaphragm. Experimental Neurology. 59: 168-75. PMID 627265 DOI: 10.1016/0014-4886(78)90210-8  0.56
1978 Younkin SG, Brett RS, Davey B, Younkin L. Substances moved by axonal transport and released by nerve stimulation have an innervation-like effect on muscle. Science (New York, N.Y.). 200: 1292-5. PMID 78522  0.56
1977 Tiedt TN, Wisler PL, Younkin SG. Neurotrophic regulation of resting membrane potential and acetylcholine sensitivity in rat extensor digitorum longus muscle. Experimental Neurology. 57: 766-91. PMID 72680 DOI: 10.1016/0014-4886(77)90107-8  0.56
1976 Tiedt TN, Younkin SG. The effect of brief exposure of rat sciatic nerve to high concentrations of colchicine Federation Proceedings. 35: No.1237.  0.56
1974 Younkin SG. An analysis of the role of calcium in facilitation at the frog neuromuscular junction. The Journal of Physiology. 237: 1-14. PMID 4545024 DOI: 10.1113/jphysiol.1974.sp010466  0.56
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