Takaomi Saido - Publications

Affiliations: 
RIKEN 
Area:
Neuropathology, Proteolysis

222 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T. Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature Communications. 10: 2964. PMID 31263162 DOI: 10.1038/s41467-019-10990-8  0.36
2019 Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T. Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature Communications. 10: 2394. PMID 31160584 DOI: 10.1038/s41467-019-10278-x  0.36
2019 Shirotani K, Hori Y, Yoshizaki R, Higuchi E, Colonna M, Saito T, Hashimoto S, Saito T, Saido TC, Iwata N. Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells. Scientific Reports. 9: 7508. PMID 31101881 DOI: 10.1038/s41598-019-43535-6  0.36
2018 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Correction for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival". Molecular and Cellular Biology. 38. PMID 29378895 DOI: 10.1128/MCB.00614-17  0.36
2017 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Expression of Concern for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival". Molecular and Cellular Biology. 37. PMID 29133537 DOI: 10.1128/MCB.00530-17  0.36
2016 Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B. Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds. Neuron. 90: 410-6. PMID 27100199 DOI: 10.1016/j.neuron.2016.03.010  0.36
2016 Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V. Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26966280 DOI: 10.1161/ATVBAHA.116.307285  0.36
2015 Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, ... ... Saido TC, et al. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine. 7: 309ra164. PMID 26468326 DOI: 10.1126/scitranslmed.aab3492  0.36
2015 Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. The Biochemical Journal. PMID 26467158 DOI: 10.1042/BJ20150607  0.36
2015 Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, Bezprozvanny I. Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13275-86. PMID 26424877 DOI: 10.1523/JNEUROSCI.1034-15.2015  0.36
2015 Hama H, Hioki H, Namiki K, Hoshida T, Kurokawa H, Ishidate F, Kaneko T, Akagi T, Saito T, Saido T, Miyawaki A. ScaleS: an optical clearing palette for biological imaging. Nature Neuroscience. 18: 1518-29. PMID 26368944 DOI: 10.1038/nn.4107  0.36
2015 Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y. Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. American Journal of Respiratory Cell and Molecular Biology. PMID 26248159 DOI: 10.1165/rcmb.2015-0151OC  0.36
2015 Nilsson P, Loganathan K, Sekiguchi M, Winblad B, Iwata N, Saido TC, Tjernberg LO. Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice. Proteomics. 15: 3349-55. PMID 26194619 DOI: 10.1002/pmic.201400211  0.36
2015 Machado VM, Morte MI, Carreira BP, Azevedo MM, Takano J, Iwata N, Saido TC, Asmussen H, Horwitz AR, Carvalho CM, Araújo IM. Involvement of calpains in adult neurogenesis: implications for stroke. Frontiers in Cellular Neuroscience. 9: 22. PMID 25698931 DOI: 10.3389/fncel.2015.00022  0.36
2015 Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. Embo Molecular Medicine. 7: 175-89. PMID 25592972 DOI: 10.15252/emmm.201404438  0.36
2015 Thal DR, Walter J, Saido TC, Fändrich M. Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease. Acta Neuropathologica. 129: 167-82. PMID 25534025 DOI: 10.1007/s00401-014-1375-y  0.36
2015 Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC. Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi. The American Journal of Pathology. 185: 305-13. PMID 25433221 DOI: 10.1016/j.ajpath.2014.10.011  0.36
2014 Kudo-Sakamoto Y, Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Sakata Y, Suzuki J, Saido TC, Komuro I. Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling. The Journal of Biological Chemistry. 289: 19408-19. PMID 24891510 DOI: 10.1074/jbc.M114.567206  0.36
2014 Nilsson P, Saito T, Saido TC. New mouse model of Alzheimer's. Acs Chemical Neuroscience. 5: 499-502. PMID 24852598 DOI: 10.1021/cn500105p  0.36
2014 Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC. Single App knock-in mouse models of Alzheimer's disease. Nature Neuroscience. 17: 661-3. PMID 24728269 DOI: 10.1038/nn.3697  0.36
2014 Nilsson P, Saido TC. Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 570-8. PMID 24711225 DOI: 10.1002/bies.201400002  0.36
2014 Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, et al. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Human Molecular Genetics. 23: 3975-89. PMID 24619358 DOI: 10.1093/hmg/ddu112  0.36
2014 Nose-Ishibashi K, Watahiki J, Yamada K, Maekawa M, Watanabe A, Yamamoto G, Enomoto A, Matsuba Y, Nampo T, Taguchi T, Ichikawa Y, Saido TC, Mishima K, Yamaguchi Y, Yoshikawa T, et al. Soft-diet feeding after weaning affects behavior in mice: Potential increase in vulnerability to mental disorders. Neuroscience. 263: 257-68. PMID 24444829 DOI: 10.1016/j.neuroscience.2013.12.065  0.36
2014 Iwata A, Nagata K, Hatsuta H, Takuma H, Bundo M, Iwamoto K, Tamaoka A, Murayama S, Saido T, Tsuji S. Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation. Human Molecular Genetics. 23: 648-56. PMID 24101602 DOI: 10.1093/hmg/ddt451  0.36
2014 Saito T, Saido TC. Animal models of Alzheimer’s disease Folia Pharmacologica Japonica. 144: 250-252. DOI: 10.1254/fpj.144.250  0.36
2013 Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nature Communications. 4: 2529. PMID 24108142 DOI: 10.1038/ncomms3529  0.36
2013 Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. Aβ secretion and plaque formation depend on autophagy. Cell Reports. 5: 61-9. PMID 24095740 DOI: 10.1016/j.celrep.2013.08.042  0.36
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, ... ... Saido TC, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/j.neuron.2013.07.037  0.36
2013 Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis. Journal of Immunology (Baltimore, Md. : 1950). 191: 3778-88. PMID 23986533 DOI: 10.4049/jimmunol.1300972  0.36
2013 Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/j.ajpath.2013.05.005  0.36
2013 Hayakawa H, Nagai M, Kawanami A, Nakata Y, Nihira T, Ogino M, Takada M, Saido T, Takano J, Saegusa M, Mikami T, Hamada J, Nishiyama K, Mochizuki H, Mizuno Y. Loss of DARPP-32 and calbindin in multiple system atrophy. Journal of Neural Transmission (Vienna, Austria : 1996). 120: 1689-98. PMID 23715974 DOI: 10.1007/s00702-013-1039-4  0.36
2013 Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M. Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates. Biochemistry. 52: 3532-42. PMID 23614719 DOI: 10.1021/bi301705c  0.36
2013 Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC. Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Scientific Reports. 3: 1472. PMID 23503602 DOI: 10.1038/srep01472  0.36
2013 Hübener J, Weber JJ, Richter C, Honold L, Weiss A, Murad F, Breuer P, Wüllner U, Bellstedt P, Paquet-Durand F, Takano J, Saido TC, Riess O, Nguyen HP. Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). Human Molecular Genetics. 22: 508-18. PMID 23100324 DOI: 10.1093/hmg/dds449  0.36
2013 Saido TC. Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease Proceedings of the Japan Academy Series B: Physical and Biological Sciences. 89: 321-339. DOI: 10.2183/pjab.89.321  0.36
2012 Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S. A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nature Communications. 3: 1307. PMID 23250437 DOI: 10.1038/ncomms2303  0.36
2012 Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, et al. Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome. The Journal of Biological Chemistry. 287: 40817-25. PMID 23033480 DOI: 10.1074/jbc.M112.398578  0.36
2012 Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Saido T, Minegishi N, Miyata T, Abe T, Yamamoto M. Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor. Neurobiology of Disease. 48: 556-67. PMID 22967911 DOI: 10.1016/j.nbd.2012.07.025  0.36
2012 Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, Nawa H, Saido TC. Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. The Journal of Biological Chemistry. 287: 29362-72. PMID 22767595 DOI: 10.1074/jbc.M112.340372  0.36
2012 Saido T, Leissring MA. Proteolytic degradation of amyloid β-protein. Cold Spring Harbor Perspectives in Medicine. 2: a006379. PMID 22675659 DOI: 10.1101/cshperspect.a006379  0.36
2012 Schoch KM, Evans HN, Brelsfoard JM, Madathil SK, Takano J, Saido TC, Saatman KE. Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Experimental Neurology. 236: 371-82. PMID 22572592 DOI: 10.1016/j.expneurol.2012.04.022  0.36
2012 Schlenzig D, Rönicke R, Cynis H, Ludwig HH, Scheel E, Reymann K, Saido T, Hause G, Schilling S, Demuth HU. N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. Journal of Neurochemistry. 121: 774-84. PMID 22375951 DOI: 10.1111/j.1471-4159.2012.07707.x  0.36
2012 Abramowski D, Rabe S, Upadhaya AR, Reichwald J, Danner S, Staab D, Capetillo-Zarate E, Yamaguchi H, Saido TC, Wiederhold KH, Thal DR, Staufenbiel M. Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1273-83. PMID 22279212 DOI: 10.1523/JNEUROSCI.4586-11.2012  0.36
2012 Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC. Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1204-17. PMID 22173972 DOI: 10.1096/fj.11-187740  0.36
2012 Ryu M, Yasuda M, Shi D, Shanab AY, Watanabe R, Himori N, Omodaka K, Yokoyama Y, Takano J, Saido T, Nakazawa T. Critical role of calpain in axonal damage-induced retinal ganglion cell death. Journal of Neuroscience Research. 90: 802-15. PMID 22065590 DOI: 10.1002/jnr.22800  0.36
2011 Saido T. [Metabolism of APP and production of Abeta]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 69: 41-7. PMID 22787751  0.36
2011 Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H. Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. Plos One. 6: e25788. PMID 21984949 DOI: 10.1371/journal.pone.0025788  0.36
2011 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Molecular and Cellular Biology. 31: 4097-106. PMID 21791606 DOI: 10.1128/MCB.05189-11  0.36
2011 Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K. An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3720-30. PMID 21746863 DOI: 10.1096/fj.11-182154  0.36
2011 Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Potent amyloidogenicity and pathogenicity of Aβ43. Nature Neuroscience. 14: 1023-32. PMID 21725313 DOI: 10.1038/nn.2858  0.36
2011 Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4720-30. PMID 21430171 DOI: 10.1523/JNEUROSCI.3076-10.2011  0.36
2011 Gomes JR, Lobo AC, Melo CV, Inácio AR, Takano J, Iwata N, Saido TC, de Almeida LP, Wieloch T, Duarte CB. Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4622-35. PMID 21430162 DOI: 10.1523/JNEUROSCI.3541-10.2011  0.36
2011 Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S. Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. Journal of Neurochemistry. 117: 504-15. PMID 21338355 DOI: 10.1111/j.1471-4159.2011.07222.x  0.36
2011 Zhang G, Thomas AL, Marshall AL, Kernan KA, Su Y, Zheng Y, Takano J, Saido TC, Eddy AA. Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 106-23. PMID 20661225 DOI: 10.1038/labinvest.2010.135  0.36
2010 Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N. Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. The Journal of Biological Chemistry. 285: 40097-103. PMID 20952385 DOI: 10.1074/jbc.M110.144626  0.36
2010 Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503  0.36
2010 Attems J, Yamaguchi H, Saido TC, Thal DR. Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology. Journal of the Neurological Sciences. 299: 155-62. PMID 20850138 DOI: 10.1016/j.jns.2010.08.030  0.36
2010 Thal DR, Papassotiropoulos A, Saido TC, Griffin WS, Mrak RE, Kölsch H, Del Tredici K, Attems J, Ghebremedhin E. Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathologica. 120: 169-83. PMID 20535486 DOI: 10.1007/s00401-010-0707-9  0.36
2010 Nilsson P, Iwata N, Muramatsu S, Tjernberg LO, Winblad B, Saido TC. Gene therapy in Alzheimer's disease - potential for disease modification. Journal of Cellular and Molecular Medicine. 14: 741-57. PMID 20158567 DOI: 10.1111/j.1582-4934.2010.01038.x  0.36
2009 Kokubo H, Kayed R, Glabe CG, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H. Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. International Journal of Alzheimer's Disease. 2009. PMID 20798763 DOI: 10.4061/2009/689285  0.36
2009 Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage K, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, et al. Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. The Journal of Biological Chemistry. 284: 33400-8. PMID 19679659 DOI: 10.1074/jbc.M109.054056  0.36
2009 Choi YS, Lee B, Cho HY, Reyes IB, Pu XA, Saido TC, Hoyt KR, Obrietan K. CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease. Neurobiology of Disease. 36: 259-68. PMID 19632326 DOI: 10.1016/j.nbd.2009.07.014  0.36
2009 Gonçalves I, Nitulescu M, Saido TC, Dias N, Pedro LM, E Fernandes JF, Ares MP, Pörn-Ares I. Activation of calpain-1 in human carotid artery atherosclerotic lesions. Bmc Cardiovascular Disorders. 9: 26. PMID 19538725 DOI: 10.1186/1471-2261-9-26  0.36
2009 Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, et al. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo. Journal of Neurochemistry. 109: 1648-57. PMID 19457098 DOI: 10.1111/j.1471-4159.2009.06069.x  0.36
2009 Adachi A, Kano F, Saido TC, Murata M. Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 14: 355-69. PMID 19210549 DOI: 10.1111/j.1365-2443.2008.01274.x  0.36
2009 Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, Yamakawa K. Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Human Molecular Genetics. 18: 1099-109. PMID 19147686 DOI: 10.1093/hmg/ddp006  0.36
2009 Nakazawa T, Shimura M, Mourin R, Kondo M, Yokokura S, Saido TC, Nishida K, Endo S. Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells. Journal of Neuroscience Research. 87: 1412-23. PMID 19105197 DOI: 10.1002/jnr.21953  0.36
2008 Nakajima R, Takao K, Huang SM, Takano J, Iwata N, Miyakawa T, Saido TC. Comprehensive behavioral phenotyping of calpastatin-knockout mice. Molecular Brain. 1: 7. PMID 18803809 DOI: 10.1186/1756-6606-1-7  0.36
2008 Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry. 47: 7405-13. PMID 18570439 DOI: 10.1021/bi800250p  0.36
2008 Wang J, Ohno-Matsui K, Yoshida T, Kojima A, Shimada N, Nakahama K, Safranova O, Iwata N, Saido TC, Mochizuki M, Morita I. Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen. Journal of Immunology (Baltimore, Md. : 1950). 181: 712-20. PMID 18566438  0.36
2008 Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, ... Saido TC, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Research. 1216: 92-103. PMID 18486110 DOI: 10.1016/j.brainres.2008.03.079  0.36
2008 Iwata N, Higuchi M, Saido TC. [Therapeutic strategy by manipulating some protease activities for Alzheimer's disease]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 131: 320-5. PMID 18480559 DOI: JST.JSTAGE/fpj/131.320  0.36
2008 Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/jbc.M801037200  0.36
2008 Tachida Y, Nakagawa K, Saito T, Saido TC, Honda T, Saito Y, Murayama S, Endo T, Sakaguchi G, Kato A, Kitazume S, Hashimoto Y. Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. Journal of Neurochemistry. 104: 1387-93. PMID 18021299 DOI: 10.1111/j.1471-4159.2007.05127.x  0.36
2007 Saido T. [Trends in mechanism-based studies on the treatment of Alzheimer's disease]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 44: 690-3. PMID 18200756  0.36
2007 Maeda J, Ji B, Irie T, Tomiyama T, Maruyama M, Okauchi T, Staufenbiel M, Iwata N, Ono M, Saido TC, Suzuki K, Mori H, Higuchi M, Suhara T. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10957-68. PMID 17928437 DOI: 10.1523/JNEUROSCI.0673-07.2007  0.36
2007 Wang J, Pignol B, Chabrier PE, Saido T, Lloyd R, Tang Y, Lenoir M, Puel JL. A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma. Neuropharmacology. 52: 1426-37. PMID 17449343 DOI: 10.1016/j.neuropharm.2007.02.007  0.36
2007 Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 53: 337-51. PMID 17270732 DOI: 10.1016/j.neuron.2007.01.010  0.36
2007 Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. The Journal of Biological Chemistry. 282: 4916-23. PMID 17170111 DOI: 10.1074/jbc.M608220200  0.36
2007 Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, Maruyama K. Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. Biochemical and Biophysical Research Communications. 352: 498-502. PMID 17125739 DOI: 10.1016/j.bbrc.2006.11.043  0.36
2007 Kamei H, Saito T, Ozawa M, Fujita Y, Asada A, Bibb JA, Saido TC, Sorimachi H, Hisanaga S. Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. The Journal of Biological Chemistry. 282: 1687-94. PMID 17121855 DOI: 10.1074/jbc.M610541200  0.36
2007 Wirths O, Weis J, Kayed R, Saido TC, Bayer TA. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiology of Aging. 28: 1689-99. PMID 16963164 DOI: 10.1016/j.neurobiolaging.2006.07.021  0.36
2007 Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VMY. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model (DOI:10.1016/j.neuron.2007.01.010) Neuron. 54: 343-344. DOI: 10.1016/j.neuron.2007.03.022  0.36
2007 Leissring M, Saido TC. Aβ degradation Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 157-178. DOI: 10.1007/978-0-387-35135-3_10  0.36
2006 Higuchi M, Saido TC, Suhara T. Animal models of tauopathies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 26: 491-7. PMID 17080730 DOI: 10.1111/j.1440-1789.2006.00685.x  0.36
2006 Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, Demuth HU. Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochimica Et Biophysica Acta. 1764: 1618-25. PMID 17005457 DOI: 10.1016/j.bbapap.2006.08.003  0.36
2006 Araya R, Noguchi T, Yuhki M, Kitamura N, Higuchi M, Saido TC, Seki K, Itohara S, Kawano M, Tanemura K, Takashima A, Yamada K, Kondoh Y, Kanno I, Wess J, et al. Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiology of Disease. 24: 334-44. PMID 16956767 DOI: 10.1016/j.nbd.2006.07.010  0.36
2006 Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS. Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry. 45: 8649-56. PMID 16834339 DOI: 10.1021/bi060597g  0.36
2006 Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, Maruyama K, Mizutani S, Ishiura S. BACE1 interacts with lipid raft proteins. Journal of Neuroscience Research. 84: 912-7. PMID 16823808 DOI: 10.1002/jnr.20981  0.36
2006 Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K. Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1. Brain Research. 1094: 192-9. PMID 16713590 DOI: 10.1016/j.brainres.2005.12.134  0.36
2006 Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, Tomita N, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Ohizumi Y, Arai H. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. Journal of Neuroscience Research. 84: 427-33. PMID 16676329 DOI: 10.1002/jnr.20891  0.36
2006 Huang SM, Mouri A, Kokubo H, Nakajima R, Suemoto T, Higuchi M, Staufenbiel M, Noda Y, Yamaguchi H, Nabeshima T, Saido TC, Iwata N. Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. The Journal of Biological Chemistry. 281: 17941-51. PMID 16636059 DOI: 10.1074/jbc.M601372200  0.36
2006 Saido TC, Iwata N. Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neuroscience Research. 54: 235-53. PMID 16457902 DOI: 10.1016/j.neures.2005.12.015  0.36
2006 Nakagawa K, Kitazume S, Oka R, Maruyama K, Saido TC, Sato Y, Endo T, Hashimoto Y. Sialylation enhances the secretion of neurotoxic amyloid-beta peptides. Journal of Neurochemistry. 96: 924-33. PMID 16412100 DOI: 10.1111/j.1471-4159.2005.03595.x  0.36
2006 Zou LB, Mouri A, Iwata N, Saido TC, Wang D, Wang MW, Mizoguchi H, Noda Y, Nabeshima T. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. The Journal of Pharmacology and Experimental Therapeutics. 317: 334-40. PMID 16382024 DOI: 10.1124/jpet.105.095687  0.36
2006 Mouri A, Zou LB, Iwata N, Saido TC, Wang D, Wang MW, Noda Y, Nabeshima T. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioural Brain Research. 168: 83-91. PMID 16360221 DOI: 10.1016/j.bbr.2005.10.014  0.36
2006 Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. Journal of Neurochemistry. 96: 533-40. PMID 16336629 DOI: 10.1111/j.1471-4159.2005.03576.x  0.36
2006 Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M. Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neuroscience Letters. 395: 37-41. PMID 16298484 DOI: 10.1016/j.neulet.2005.10.087  0.36
2005 Iwata N, Saido TC, Mizukami H, Ozawa K. [Experimental gene therapy for Alzheimer's disease--animal models]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 63: 691-8. PMID 16416874  0.36
2005 Iwata N, Higuchi M, Saito T, Saido TC. [Presymptomatic diagnosis, prevention and therapy]. Nō to Shinkei = Brain and Nerve. 57: 855-66. PMID 16277230  0.36
2005 Ogawa T, Kiryu-Seo S, Tanaka M, Konishi H, Iwata N, Saido T, Watanabe Y, Kiyama H. Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue. Journal of Neurochemistry. 95: 1156-66. PMID 16271049 DOI: 10.1111/j.1471-4159.2005.03436.x  0.36
2005 Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathologica. 110: 459-71. PMID 16195918 DOI: 10.1007/s00401-005-1053-1  0.36
2005 Yoshida T, Ohno-Matsui K, Ichinose S, Sato T, Iwata N, Saido TC, Hisatomi T, Mochizuki M, Morita I. The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. The Journal of Clinical Investigation. 115: 2793-800. PMID 16167083 DOI: 10.1172/JCI24635  0.36
2005 Iwata N, Higuchi M, Saido TC. Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacology & Therapeutics. 108: 129-48. PMID 16112736 DOI: 10.1016/j.pharmthera.2005.03.010  0.36
2005 Piccini A, Russo C, Gliozzi A, Relini A, Vitali A, Borghi R, Giliberto L, Armirotti A, D'Arrigo C, Bachi A, Cattaneo A, Canale C, Torrassa S, Saido TC, Markesbery W, et al. beta-amyloid is different in normal aging and in Alzheimer disease. The Journal of Biological Chemistry. 280: 34186-92. PMID 16103127 DOI: 10.1074/jbc.M501694200  0.36
2005 Higuchi M, Iwata N, Saido TC. Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochimica Et Biophysica Acta. 1751: 60-7. PMID 16054018 DOI: 10.1016/j.bbapap.2005.02.013  0.36
2005 Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto M, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, Ozawa K, Saido TC, Arai H, Sasaki H. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Annals of Neurology. 57: 832-42. PMID 15929037 DOI: 10.1002/ana.20494  0.36
2005 Hama E, Saido TC. Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide. Medical Hypotheses. 65: 498-500. PMID 15921860 DOI: 10.1016/j.mehy.2005.02.045  0.36
2005 Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamaguchi H. Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Research. 1045: 224-8. PMID 15910781 DOI: 10.1016/j.brainres.2005.03.017  0.36
2005 Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. Febs Letters. 579: 2907-12. PMID 15890346 DOI: 10.1016/j.febslet.2005.04.037  0.36
2005 Hayashi M, Koshihara Y, Ishibashi H, Yamamoto S, Tsubuki S, Saido TC, Kawashima S, Inomata M. Involvement of calpain in osteoclastic bone resorption. Journal of Biochemistry. 137: 331-8. PMID 15809334 DOI: 10.1093/jb/mvi036  0.36
2005 Kambe A, Yokota M, Saido TC, Satokata I, Fujikawa H, Tabuchi S, Kamitani H, Watanabe T. Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia. Brain Research. 1040: 36-43. PMID 15804424 DOI: 10.1016/j.brainres.2005.01.080  0.36
2005 Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC. Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nature Medicine. 11: 434-9. PMID 15778722 DOI: 10.1038/nm1206  0.36
2005 Iwata N, Ozawa K, Saido TC. [Gene therapy for Alzheimer' s disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 63: 394-400. PMID 15773336  0.36
2005 Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC. 19F and 1H MRI detection of amyloid beta plaques in vivo. Nature Neuroscience. 8: 527-33. PMID 15768036 DOI: 10.1038/nn1422  0.36
2005 Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, Maki M, Itohara S, Saido TC. Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. The Journal of Biological Chemistry. 280: 15229-37. PMID 15699033 DOI: 10.1074/jbc.M500939200  0.36
2005 Shin RW, Saido TC, Maeda M, Kitamoto T. Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells. Neuroscience Letters. 376: 14-9. PMID 15694266 DOI: 10.1016/j.neulet.2004.11.032  0.36
2005 Takano J, Tomioka M, Tsubuki S, Higuchi M, Iwata N, Itohara S, Maki M, Saido TC. Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. The Journal of Biological Chemistry. 280: 16175-84. PMID 15691848 DOI: 10.1074/jbc.M414552200  0.36
2005 Kokubo H, Saido TC, Iwata N, Helms JB, Shinohara R, Yamaguchi H. Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiology of Aging. 26: 409-18. PMID 15653169 DOI: 10.1016/j.neurobiolaging.2004.04.008  0.36
2005 Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 436-45. PMID 15647487 DOI: 10.1523/JNEUROSCI.1575-04.2005  0.36
2005 Bialkowska K, Saido TC, Fox JE. SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. Journal of Cell Science. 118: 381-95. PMID 15632109 DOI: 10.1242/jcs.01625  0.36
2004 Saido TC. [Towards presymptomatic diagnosis, prevention and treatment of Alzheimer's disease]. Rinshō Shinkeigaku = Clinical Neurology. 44: 775-7. PMID 15651288  0.36
2004 Kitazume S, Kotani N, Nakato H, Saido T, Hashimoto Y. [Glycosyltransferases as substrates for Alzheimer's beta-secretase]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 49: 2468-72. PMID 15553003  0.36
2004 Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry. 43: 13532-40. PMID 15491160 DOI: 10.1021/bi049399k  0.36
2004 Kitazume S, Suzuki M, Saido TC, Hashimoto Y. Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase. Glycoconjugate Journal. 21: 25-9. PMID 15467394 DOI: 10.1023/B:GLYC.0000043743.21735.ff  0.36
2004 Ladrech S, Guitton M, Saido T, Lenoir M. Calpain activity in the amikacin-damaged rat cochlea. The Journal of Comparative Neurology. 477: 149-60. PMID 15300786 DOI: 10.1002/cne.20252  0.36
2004 Sato K, Higuchi M, Iwata N, Saido TC, Sasamoto K. Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. European Journal of Medicinal Chemistry. 39: 573-8. PMID 15236837 DOI: 10.1016/j.ejmech.2004.02.013  0.36
2004 Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K. Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 75: 1039-42. PMID 15201367 DOI: 10.1136/jnnp.2003.010611  0.36
2004 Hama E, Shirotani K, Iwata N, Saido TC. Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. The Journal of Biological Chemistry. 279: 30259-64. PMID 15100223 DOI: 10.1074/jbc.M401891200  0.36
2004 Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y. KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorganic & Medicinal Chemistry Letters. 14: 1527-31. PMID 15006396 DOI: 10.1016/j.bmcl.2003.12.088  0.36
2004 Kitazume S, Saido TC, Hashimoto Y. Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconjugate Journal. 20: 59-62. PMID 14973371 DOI: 10.1023/B:GLYC.0000016743.25495.45  0.36
2004 Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 991-8. PMID 14749444 DOI: 10.1523/JNEUROSCI.4792-03.2004  0.36
2003 Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R. The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. The Embo Journal. 22: 6665-74. PMID 14657037 DOI: 10.1093/emboj/cdg634  0.36
2003 Yamashima T, Tonchev AB, Tsukada T, Saido TC, Imajoh-Ohmi S, Momoi T, Kominami E. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus. 13: 791-800. PMID 14620874 DOI: 10.1002/hipo.10127  0.36
2003 Wang DS, Iwata N, Hama E, Saido TC, Dickson DW. Oxidized neprilysin in aging and Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 310: 236-41. PMID 14511676 DOI: 10.1016/j.bbrc.2003.09.003  0.36
2003 Yokota M, Saido TC, Kamitani H, Tabuchi S, Satokata I, Watanabe T. Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain. Brain Research. 984: 122-32. PMID 12932846 DOI: 10.1016/S0006-8993(03)03121-4  0.36
2003 Saito T, Takaki Y, Iwata N, Trojanowski J, Saido TC. Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism. Science of Aging Knowledge Environment : Sage Ke. 2003: PE1. PMID 12844556  0.36
2003 Iwata N, Saido TC. [Amyloid-beta peptide metabolism and Alzheimer's disease]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 122: 5-14. PMID 12843567 DOI: 10.1254/fpj.122.5  0.36
2003 Kitazume-Kawaguchi S, Hashimoto Y, Saido T. [BACE1 and glycosyltransferases]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 48: 984-9. PMID 12806999  0.36
2003 Tsubuki S, Takaki Y, Saido TC. Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation. Lancet. 361: 1957-8. PMID 12801742 DOI: 10.1016/S0140-6736(03)13555-6  0.36
2003 Pörn-Ares MI, Saido TC, Andersson T, Ares MP. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. The Biochemical Journal. 374: 403-11. PMID 12775216 DOI: 10.1042/BJ20021955  0.36
2003 Zhang J, Miyamoto K, Hashioka S, Hao HP, Murao K, Saido TC, Nakanishi H. Activation of mu-calpain in developing cortical neurons following methylmercury treatment. Brain Research. Developmental Brain Research. 142: 105-10. PMID 12694949 DOI: 10.1016/S0165-3806(03)00057-9  0.36
2003 Kitazume S, Tachida Y, Oka R, Kotani N, Ogawa K, Suzuki M, Dohmae N, Takio K, Saido TC, Hashimoto Y. Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). The Journal of Biological Chemistry. 278: 14865-71. PMID 12473667 DOI: 10.1074/jbc.M206262200  0.36
2003 Rami A, Volkmann T, Agarwal R, Schoninger S, Nürnberger F, Saido TC, Winckler J. β2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia Neuroscience Research. 47: 373-382. DOI: 10.1016/j.neures.2003.07.002  0.36
2002 Tomioka M, Shirotani K, Iwata N, Lee HJ, Yang F, Cole GM, Seyama Y, Saido TC. In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Brain Research. Molecular Brain Research. 108: 18-32. PMID 12480175 DOI: 10.1016/S0169-328X(02)00486-2  0.36
2002 Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 9: 88-102. PMID 12440481  0.36
2002 Kuwako K, Nishimura I, Uetsuki T, Saido TC, Yoshikawa K. Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Brain Research. Molecular Brain Research. 107: 166-75. PMID 12425945 DOI: 10.1016/S0169-328X(02)00489-8  0.36
2002 Kitazume S, Saido TC, Hashimoto Y. [Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase]. Seikagaku. the Journal of Japanese Biochemical Society. 74: 1180-3. PMID 12402461  0.36
2002 Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC. Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. Journal of Neuroscience Research. 70: 493-500. PMID 12391610 DOI: 10.1002/jnr.10390  0.36
2002 Takahashi M, Fukami S, Iwata N, Inoue K, Itohara S, Itoh H, Haraoka J, Saido T. In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 46: 155-63. PMID 12220955 DOI: 10.1016/S1043-6618(02)00081-6  0.36
2002 Shirotani K, Tsubuki S, Lee HJ, Maruyama K, Saido TC. Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons. Neuroscience Letters. 327: 25-8. PMID 12098492 DOI: 10.1016/S0304-3940(02)00351-8  0.36
2002 Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neuroscience Research. 43: 39-56. PMID 12074840 DOI: 10.1016/S0168-0102(02)00015-9  0.36
2002 Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S. BACE1 interacts with nicastrin. Biochemical and Biophysical Research Communications. 293: 1228-32. PMID 12054507 DOI: 10.1016/S0006-291X(02)00351-0  0.36
2002 Daré E, Tofighi R, Vettori MV, Momoi T, Poli D, Saido TC, Mutti A, Ceccatelli S. Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Research. 933: 12-22. PMID 11929631 DOI: 10.1016/S0006-8993(02)02274-6  0.36
2002 Fukami S, Iwata N, Saido TC. Therapeutic strategies of Alzheimer's disease through manipulation of Aβ metabolism: A focus on Aβ-degrading peptidase, neprilysin Drug Development Research. 56: 171-183. DOI: 10.1002/ddr.10073  0.36
2001 Kim JE, Han BS, Choi WS, Eom DS, Lee EH, Oh TH, Markelonis GJ, Saido TC, Lee GE, Chung IK, Oh YJ. Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X(L). Journal of Neuroscience Research. 66: 1074-82. PMID 11746439 DOI: 10.1002/jnr.10028  0.36
2001 Kaneko T, Yamashima T, Tohma Y, Nomura M, Imajoh-Ohmi S, Saido TC, Nakao M, Saya H, Yamamoto H, Yamashita J. Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis. Cancer. 92: 2662-72. PMID 11745202 DOI: 10.1002/1097-0142(20011115)92:10<2662::AID-CNCR1620>3.0.CO;2-9  0.36
2001 Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC. Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons. Journal of Biochemistry. 130: 721-6. PMID 11726269  0.36
2001 Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 98: 13554-9. PMID 11698669 DOI: 10.1073/pnas.241509198  0.36
2001 Morishima-Kawashima M, Saido TC, Ihara Y. [Alzheimer's disease and the proteins]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 46: 1798-804. PMID 11579581  0.36
2001 Russo C, Schettini G, Saido TC, Gambetti P, Tabaton M, Teller JT, Larner AJ. N-terminal truncated amyloid β-peptides and Alzheimer's disease (multiple letters) Neurobiology of Aging. 22: 343-345. PMID 11414252 DOI: 10.1016/S0197-4580(01)00212-3  0.36
2001 Choi WS, Lee EH, Chung CW, Jung YK, Jin BK, Kim SU, Oh TH, Saido TC, Oh YJ. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2. Journal of Neurochemistry. 77: 1531-41. PMID 11413236 DOI: 10.1046/j.1471-4159.2001.00368.x  0.36
2001 Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Metabolic regulation of brain Abeta by neprilysin. Science (New York, N.Y.). 292: 1550-2. PMID 11375493 DOI: 10.1126/science.1059946  0.36
2001 Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/jbc.M008511200  0.36
2001 Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido TC. Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. The European Journal of Neuroscience. 13: 935-48. PMID 11264666 DOI: 10.1046/j.0953-816X.2001.01462.x  0.36
2001 Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. Febs Letters. 489: 46-50. PMID 11231011 DOI: 10.1016/S0014-5793(00)02431-5  0.36
2001 Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 372-81. PMID 11160418  0.36
2000 Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, Gerard NP, Gerard C, Lee HJ, Shirotani K, Saido TC. Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain. Journal of Biochemistry. 128: 897-902. PMID 11098130  0.36
2000 Bialkowska K, Kulkarni S, Du X, Goll DE, Saido TC, Fox JE. Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active. The Journal of Cell Biology. 151: 685-96. PMID 11062268 DOI: 10.1083/jcb.151.3.685  0.36
2000 Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochemical and Biophysical Research Communications. 276: 422-7. PMID 11027491 DOI: 10.1006/bbrc.2000.3490  0.36
2000 Lee HJ, Tomioka M, Takaki Y, Masumoto H, Saido TC. Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus. Biochimica Et Biophysica Acta. 1493: 273-8. PMID 10978538 DOI: 10.1016/S0167-4781(00)00183-4  0.36
2000 Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American Journal of Pathology. 157: 331-9. PMID 10880403  0.36
2000 Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK. Presenilin-1 mutations in Alzheimer's disease. Nature. 405: 531-2. PMID 10850703 DOI: 10.1038/35014735  0.36
2000 Kitagaki H, Tomioka S, Yoshizawa T, Sorimachi H, Saido TC, Ishiura S, Suzuki K. Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain. Bioscience, Biotechnology, and Biochemistry. 64: 689-95. PMID 10830478 DOI: 10.1271/bbb.64.689  0.36
2000 Lankiewicz S, Marc Luetjens C, Truc Bui N, Krohn AJ, Poppe M, Cole GM, Saido TC, Prehn JH. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. The Journal of Biological Chemistry. 275: 17064-71. PMID 10828077 DOI: 10.1074/jbc.275.22.17064  0.36
2000 Hiwasa T, Arase Y, Kikuno K, Hasegawa R, Sugaya S, Kita K, Saido T, Yamamori H, Maki M, Suzuki N. Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death and Differentiation. 7: 531-7. PMID 10822276 DOI: 10.1038/sj.cdd.4400685  0.36
2000 Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VM, Trojanowski JQ. Brain trauma in aged transgenic mice induces regression of established abeta deposits. Experimental Neurology. 163: 244-52. PMID 10785464 DOI: 10.1006/exnr.2000.7375  0.36
2000 Saido TC. Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat/polyglutamine-expansion diseases. Medical Hypotheses. 54: 427-9. PMID 10783480 DOI: 10.1054/mehy.1999.0866  0.36
2000 Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S. Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice. The Journal of Pathology. 191: 93-101. PMID 10767725 DOI: 10.1002/(SICI)1096-9896(200005)191:1<93::AID-PATH567>3.0.CO;2-Q  0.36
2000 Yamaguchi A, Yamamoto N, Akamatsu N, Saido TC, Kaneda M, Umeda M, Tanoue K. PS-liposome and ox-LDL bind to different sites of the immunodominant domain (#155-183) of CD36: a study with GS95, a new anti-CD36 monoclonal antibody. Thrombosis Research. 97: 317-26. PMID 10709907 DOI: 10.1016/S0049-3848(99)00179-6  0.36
2000 Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. International Journal of Molecular Medicine. 5: 269-73. PMID 10677567  0.36
2000 Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nature Medicine. 6: 143-50. PMID 10655101 DOI: 10.1038/72237  0.36
2000 Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S. Metabolism of amyloid precursor protein in COS cells transfected with a β-secretase candidate Cytotechnology. 33: 213-219.  0.36
2000 Saido TC. Degradation of amyloid-beta peptide: A key to Alzheimer pathogenesis, prevention and therapy Neuroscience News. 3: 52-62.  0.36
1999 Koriyama H, Kouchi Z, Umeda T, Saido TC, Momoi T, Ishiura S, Suzuki K. Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cellular Signalling. 11: 831-8. PMID 10617286 DOI: 10.1016/S0898-6568(99)00055-8  0.36
1999 Schmidt ML, Saido TC, Lee VM, Trojanowski JQ. Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain. Journal of Neuropathology and Experimental Neurology. 58: 1227-33. PMID 10604747  0.36
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10627-34. PMID 10594046  0.36
1999 Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T. Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42. Neuroreport. 10: 2965-9. PMID 10549806  0.36
1999 Hayashi M, Suzuki H, Kawashima S, Saido TC, Inomata M. The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways. Archives of Biochemistry and Biophysics. 371: 133-41. PMID 10545199 DOI: 10.1006/abbi.1999.1427  0.36
1999 Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S. Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. The Biochemical Journal. 343: 371-5. PMID 10510302 DOI: 10.1042/0264-6021:3430371  0.36
1999 Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proceedings of the National Academy of Sciences of the United States of America. 96: 11486-91. PMID 10500203 DOI: 10.1073/pnas.96.20.11486  0.36
1999 McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/nbdi.1999.0243  0.36
1999 Kubo H, Matsushita M, Kotani M, Kawasaki H, Saido TC, Kawashima S, Katagiri C, Suzuki A. Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes. Developmental Genetics. 25: 123-9. PMID 10440846 DOI: 10.1002/(SICI)1520-6408(1999)25:2<123::AID-DVG6>3.0.CO;2-3  0.36
1999 Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VM, Trojanowski JQ. Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging. The Journal of Comparative Neurology. 411: 390-8. PMID 10413774 DOI: 10.1002/(SICI)1096-9861(19990830)411:3<390::AID-CNE3>3.0.CO;2-#  0.36
1999 Kulkarni S, Saido TC, Suzuki K, Fox JE. Calpain mediates integrin-induced signaling at a point upstream of Rho family members. The Journal of Biological Chemistry. 274: 21265-75. PMID 10409684 DOI: 10.1074/jbc.274.30.21265  0.36
1999 Koike H, Seki H, Kouchi Z, Ito M, Kinouchi T, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Suzuki K, Ishiura S. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. Journal of Biochemistry. 126: 235-42. PMID 10393344  0.36
1999 Eto A, Saido TC, Fukushima K, Tomioka S, Imai S, Nisizawa T, Hanada N. Inhibitory effect of a self-derived peptide on glucosyltransferase of Streptococcus mutans. Possible novel anticaries measures. The Journal of Biological Chemistry. 274: 15797-802. PMID 10336482 DOI: 10.1074/jbc.274.22.15797  0.36
1999 Blomgren K, Hallin U, Andersson AL, Puka-Sundvall M, Bahr BA, McRae A, Saido TC, Kawashima S, Hagberg H. Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia. The Journal of Biological Chemistry. 274: 14046-52. PMID 10318818 DOI: 10.1074/jbc.274.20.14046  0.36
1999 Yokota M, Tani E, Tsubuki S, Yamaura I, Nakagaki I, Hori S, Saido TC. Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage. Brain Research. 819: 8-14. PMID 10082855 DOI: 10.1016/S0006-8993(98)01334-1  0.36
1999 Kitagawa K, Matsumoto M, Saido TC, Ohtsuki T, Kuwabara K, Yagita Y, Mabuchi T, Yanagihara T, Hori M. Species differences in fodrin proteolysis in the ischemic brain. Journal of Neuroscience Research. 55: 643-9. PMID 10082086 DOI: 10.1002/(SICI)1097-4547(19990301)55:5<643::AID-JNR11>3.0.CO;2-V  0.36
1999 Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia. 25: 324-31. PMID 10028915 DOI: 10.1002/(SICI)1098-1136(19990215)25:4<324::AID-GLIA2>3.0.CO;2-5  0.36
1999 Ray SK, Shields DC, Saido TC, Matzelle DC, Wilford GG, Hogan EL, Banik NL. Calpain activity and translational expression increased in spinal cord injury. Brain Research. 816: 375-80. PMID 9878837 DOI: 10.1016/S0006-8993(98)01128-7  0.36
1998 Frautschy SA, Horn DL, Sigel JJ, Harris-White ME, Mendoza JJ, Yang F, Saido TC, Cole GM. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8311-21. PMID 9763475  0.36
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880  0.36
1998 Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. The American Journal of Pathology. 152: 983-92. PMID 9546359  0.36
1998 Yamaguchi H, Sugihara S, Ogawa A, Saido TC, Ihara Y. Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques. Acta Neuropathologica. 95: 217-22. PMID 9542585 DOI: 10.1007/s004010050790  0.36
1998 Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. Acta Neuropathologica. 95: 117-22. PMID 9498044 DOI: 10.1007/s004010050774  0.36
1997 Shin RW, Ogino K, Kondo A, Saido TC, Trojanowski JQ, Kitamoto T, Tateishi J. Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8187-93. PMID 9334394  0.36
1997 Russo C, Saido TC, DeBusk LM, Tabaton M, Gambetti P, Teller JK. Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains. Febs Letters. 409: 411-6. PMID 9224700 DOI: 10.1016/S0014-5793(97)00564-4  0.36
1997 Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/bi970209y  0.36
1997 Saido TC, Kawashima S, Tani E, Yokota M. Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus. Neuroscience Letters. 227: 75-8. PMID 9180207 DOI: 10.1016/S0304-3940(97)00309-1  0.36
1996 Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiology of Disease. 3: 16-32. PMID 9173910 DOI: 10.1006/nbdi.1996.0003  0.36
1996 Yokota M, Saido TC, Tani E, Yamaura I, Minami N. Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 1219-23. PMID 8898694 DOI: 10.1097/00004647-199611000-00016  0.36
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/nm1096-1146  0.36
1995 Bednarski E, Vanderklish P, Gall C, Saido TC, Bahr BA, Lynch G. Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices. Brain Research. 694: 147-57. PMID 8974639 DOI: 10.1016/0006-8993(95)00851-G  0.36
1995 Yokota M, Saido TC, Tani E, Kawashima S, Suzuki K. Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease. Stroke; a Journal of Cerebral Circulation. 26: 1901-7. PMID 7570746  0.36
1994 Saido TC, Yokota M, Maruyama K, Yamao-Harigaya W, Tani E, Ihara Y, Kawashima S. Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus. The Journal of Biological Chemistry. 269: 15253-7. PMID 8195161  0.36
1994 Yokota M, Saido TC, Miyaji K, Tani E, Kawashima S, Suzuki K. Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia. Neuroscience Letters. 168: 69-72. PMID 7518068 DOI: 10.1016/0304-3940(94)90418-9  0.36
1993 Yamaura I, Tani E, Saido TC, Suzuki K, Minami N, Maeda Y. Calpain-calpastatin system of canine basilar artery in vasospasm. Journal of Neurosurgery. 79: 537-43. PMID 8410223 DOI: 10.3171/jns.1993.79.4.0537  0.36
1993 Saido TC, Yokota M, Nagao S, Yamaura I, Tani E, Tsuchiya T, Suzuki K, Kawashima S. Spatial resolution of fodrin proteolysis in postischemic brain. The Journal of Biological Chemistry. 268: 25239-43. PMID 8227089  0.36
1992 Kawashima S, Saido TC. [Physiological function of calpains]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 37: 2144-60. PMID 1529105  0.36
1991 Mori A, Aizawa H, Saido TC, Kawasaki H, Mizuno K, Murofushi H, Suzuki K, Sakai H. Site-specific phosphorylation by protein kinase C inhibits assembly-promoting activity of microtubule-associated protein 4. Biochemistry. 30: 9341-6. PMID 1892837  0.36
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