Howard J. Federoff - Publications

Affiliations: 
Center for Aging and Developmental Biology University of Rochester Medical Center, Rochester, NY, United States 

221 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff HJ. Alpha-Synuclein mRNA Is Not Increased. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28522034 DOI: 10.1016/j.ymthe.2017.04.018  0.96
2015 Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff HJ. PGC-1α Promoter Methylation in Parkinson's Disease. Plos One. 10: e0134087. PMID 26317511 DOI: 10.1371/journal.pone.0134087  0.96
2015 Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, ... Federoff HJ, et al. Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Frontiers in Human Neuroscience. 9: 231. PMID 25972803 DOI: 10.3389/fnhum.2015.00231  1
2015 Cheever TR, Berkley D, Braun S, Brown RH, Byrne BJ, Chamberlain JS, Cwik V, Duan D, Federoff HJ, High KA, Kaspar BK, Klinger KW, Larkindale J, Lincecum J, Mavilio F, et al. Perspectives on best practices for gene therapy programs. Human Gene Therapy. 26: 127-33. PMID 25654329 DOI: 10.1089/hum.2014.147  1
2015 Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 600-7.e1. PMID 25130657 DOI: 10.1016/j.jalz.2014.06.008  1
2014 Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Medicine. 6: 82. PMID 25473422 DOI: 10.1186/s13073-014-0082-6  1
2014 Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S196-212. PMID 24924671 DOI: 10.1016/j.jalz.2014.04.015  1
2014 Su X, Federoff HJ. Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Research International. 2014: 275178. PMID 24822191 DOI: 10.1155/2014/275178  1
2014 O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, et al. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Human Gene Therapy. 25: 488-97. PMID 24773122 DOI: 10.1089/hum.2014.045  1
2014 Federoff HJ, Wagner JE. The evolution of gene transfer, gene therapy, and the RAC: IOM recommendations to the NIH director. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 685-6. PMID 24691174 DOI: 10.1038/mt.2014.37  1
2014 Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, ... ... Federoff HJ, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nature Medicine. 20: 415-8. PMID 24608097 DOI: 10.1038/nm.3466  1
2014 Fiandaca MS, Federoff HJ. Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding? Experimental Neurology. 256: 117-25. PMID 23524194 DOI: 10.1016/j.expneurol.2013.03.014  1
2013 Huang L, Su X, Federoff HJ. Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. International Journal of Molecular Sciences. 14: 19109-27. PMID 24048248 DOI: 10.3390/ijms140919109  1
2013 Huang L, Shimoji M, Wang J, Shah S, Kamila S, Biehl ER, Lim S, Chang A, Maguire-Zeiss KA, Su X, Federoff HJ. Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 840-51. PMID 23963789 DOI: 10.1007/s13311-013-0208-3  1
2013 MacArthur L, Ressom H, Shah S, Federoff HJ. Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease. Expert Review of Neurotherapeutics. 13: 685-93. PMID 23739005 DOI: 10.1586/ern.13.59  1
2013 Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA. Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 94-117. PMID 23054368 DOI: 10.1007/s11481-012-9401-0  1
2013 Burger EW, Federoff HJ, Fiandaca MS, Frieder O, Goharian N, Yates A. Social media communications networks and pharmacovigilance: SequelAE-2.0 2013 Ieee 15th International Conference On E-Health Networking, Applications and Services, Healthcom 2013. DOI: 10.1109/HealthCom.2013.6720777  1
2012 Fiandaca MS, Bankiewicz KS, Federoff HJ. Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel, Switzerland). 5: 553-90. PMID 24281662 DOI: 10.3390/ph5060553  1
2012 Scholz SW, Mhyre T, Ressom H, Shah S, Federoff HJ. Genomics and bioinformatics of Parkinson's disease. Cold Spring Harbor Perspectives in Medicine. 2: a009449. PMID 22762024 DOI: 10.1101/cshperspect.a009449  1
2012 Galpern WR, Corrigan-Curay J, Lang AE, Kahn J, Tagle D, Barker RA, Freeman TB, Goetz CG, Kieburtz K, Kim SY, Piantadosi S, Comstock Rick A, Federoff HJ. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. The Lancet. Neurology. 11: 643-50. PMID 22710757 DOI: 10.1016/S1474-4422(12)70064-9  1
2012 Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff HJ, Traynor BJ, Singleton AB, Houlden H. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 79: 127-31. PMID 22675081 DOI: 10.1212/WNL.0b013e31825f048e  1
2012 Lim ST, Chang A, Giuliano RE, Federoff HJ. Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density. Journal of Neurochemistry. 120: 741-51. PMID 22118475 DOI: 10.1111/j.1471-4159.2011.07592.x  1
2011 Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. Plos One. 6: e27728. PMID 22132130 DOI: 10.1371/journal.pone.0027728  1
2011 Sanberg PR, Vindrola-Padros C, Eve DJ, Federoff HJ. Technology and innovation: 2010 a year in review. Cell Transplantation. 20: 1315-9. PMID 22080749 DOI: 10.3727/096368911X593127  1
2011 Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. The European Journal of Neuroscience. 34: 1256-67. PMID 21995852 DOI: 10.1111/j.1460-9568.2011.07862.x  1
2011 Kim J, Chang A, Dudak A, Federoff HJ, Lim ST. Characterization of nectin processing mediated by presenilin-dependent γ-secretase. Journal of Neurochemistry. 119: 945-56. PMID 21910732 DOI: 10.1111/j.1471-4159.2011.07479.x  1
2011 Dudak A, Kim J, Cheong B, Federoff HJ, Lim ST. Membrane palmitoylated proteins regulate trafficking and processing of nectins. European Journal of Cell Biology. 90: 365-75. PMID 21371776 DOI: 10.1016/j.ejcb.2011.01.004  1
2011 Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1048-57. PMID 21343917 DOI: 10.1038/mt.2011.11  1
2011 Shah S, Federoff HJ. Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy. 3: 287-98. PMID 21322764 DOI: 10.2217/imt.10.94  1
2011 Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proceedings of the National Academy of Sciences of the United States of America. 108: 852-7. PMID 21187387 DOI: 10.1073/pnas.1015981108  1
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-1481. PMID 28178507 DOI: 10.1038/mt.2010.111  1
2010 Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, ... Federoff HJ, et al. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Science Translational Medicine. 2: 52ra73. PMID 20926834 DOI: 10.1126/scitranslmed.3001059  1
2010 Federoff HJ, Rubin ER. A new research and development policy framework for the biomedical research enterprise. Jama. 304: 1003-4. PMID 20810378 DOI: 10.1001/jama.2010.1270  1
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/nm.2199  1
2010 Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9567-77. PMID 20631185 DOI: 10.1523/JNEUROSCI.0942-10.2010  1
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-81. PMID 20551911 DOI: 10.1038/mt.2010.111  1
2010 Feng LR, Federoff HJ, Vicini S, Maguire-Zeiss KA. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. The European Journal of Neuroscience. 32: 10-7. PMID 20550572 DOI: 10.1111/j.1460-9568.2010.07266.x  0.88
2010 Maguire-Zeiss KA, Federoff HJ. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 1019-25. PMID 20549523 DOI: 10.1007/s00702-010-0431-6  1
2010 Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST. Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). The Journal of Biological Chemistry. 285: 22919-26. PMID 20501653 DOI: 10.1074/jbc.M110.126649  1
2010 Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. Journal of Neuroscience Methods. 190: 171-9. PMID 20452375 DOI: 10.1016/j.jneumeth.2010.05.001  1
2010 Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. The Journal of Biological Chemistry. 285: 21329-40. PMID 20448044 DOI: 10.1074/jbc.M109.095299  1
2010 Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. Plos One. 5: e9002. PMID 20126313 DOI: 10.1371/journal.pone.0009002  1
2010 de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Therapy. 17: 424-31. PMID 19865178 DOI: 10.1038/gt.2009.144  1
2010 Alaoui A, Kim D, Levine B, Cleary K, Federoff HJ, Mhyre T. Framework design and development of an informatics architecture for a systems biology approach to traumatic brain injury Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7628. DOI: 10.1117/12.846090  1
2010 Federoff HJ, Rubin ER. Multidisciplinary approaches to biomedical research: Reply Jama - Journal of the American Medical Association. 304: 2244. DOI: 10.1001/jama.2010.1704  1
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-2040. PMID 28178451 DOI: 10.1038/mt.2009.174  1
2009 Zaia JA, Federoff HJ. Death in a gene-therapy trial. The New England Journal of Medicine. 361: 1811. PMID 19864684 DOI: 10.1056/NEJMc091613  1
2009 Shah S, Federoff HJ. Drug discovery dilemma and Cura quartet collaboration. Drug Discovery Today. 14: 1006-10. PMID 19815089 DOI: 10.1016/j.drudis.2009.09.007  1
2009 Luo Y, Sarabi SA, Backman C, Shan L, Hoffer B, Federoff H. Expression pattern of NuIP gene in adult mouse brain. Brain Research. 1302: 42-53. PMID 19765553 DOI: 10.1016/j.brainres.2009.09.026  1
2009 Federoff HJ, Gostin LO. Evolving from reductionism to holism: is there a future for systems medicine? Jama. 302: 994-6. PMID 19724047 DOI: 10.1001/jama.2009.1264  1
2009 Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Human Gene Therapy. 20: 1627-40. PMID 19671001 DOI: 10.1089/hum.2009.103  1
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-40. PMID 19638957 DOI: doi:10.1038/mt.2009.174  1
2009 Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. The Journal of Cell Biology. 185: 1065-81. PMID 19528298 DOI: 10.1083/jcb.200811033  1
2009 Su X, Federoff HJ, Maguire-Zeiss KA. Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotoxicity Research. 16: 238-54. PMID 19526281 DOI: 10.1007/s12640-009-9053-x  1
2009 Federoff HJ. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotoxicity Research. 16: 261-70. PMID 19526279 DOI: 10.1007/s12640-009-9056-7  1
2009 Federoff HJ. Development of vaccination approaches for the treatment of neurological diseases. The Journal of Comparative Neurology. 515: 4-14. PMID 19399901 DOI: 10.1002/cne.22034  1
2009 Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Human Gene Therapy. 20: 511-8. PMID 19254173 DOI: 10.1089/hum.2008.201  1
2009 Ryan DA, Federoff HJ. Immune responses to herpesviral vectors. Human Gene Therapy. 20: 434-41. PMID 19216681 DOI: 10.1089/hum.2009.019  1
2009 Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Human Gene Therapy. 20: 497-510. PMID 19203243 DOI: 10.1089/hum.2008.137  1
2009 Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Human Gene Therapy. 20: 442-52. PMID 19199821 DOI: 10.1089/hum.2008.160  1
2009 Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain Neuroimage. 47: T27-T35. PMID 19095069 DOI: 10.1016/j.neuroimage.2008.11.012  1
2009 Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 113: 3264-75. PMID 18952891 DOI: 10.1182/blood-2008-07-168203  1
2009 Maguire-Zeiss KA, Federoff HJ. Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 298-308. PMID 18931916 DOI: 10.1007/s11481-008-9133-3  1
2009 Federoff HJ, Brown M, Dakshanamurthy S, Maguire-Zeiss K. Potential of Nurr1 interactions to disclose new Parkinson's therapeutics Future Neurology. 4: 161-165. DOI: 10.2217/14796708.4.2.161  1
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-853. PMID 28178487 DOI: 10.1038/mt.2008.39  1
2008 Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. The American Journal of Pathology. 173: 1768-82. PMID 18974297 DOI: 10.2353/ajpath.2008.080528  1
2008 Luo Y, Xing F, Guiliano R, Federoff HJ. Identification of a novel nurr1-interacting protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9277-86. PMID 18784308 DOI: 10.1523/JNEUROSCI.3021-08.2008  1
2008 Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1392-9. PMID 18545225 DOI: 10.1038/mt.2008.113  1
2008 Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Molecular and Cellular Neurosciences. 38: 125-37. PMID 18439838 DOI: 10.1016/j.mcn.2008.01.014  1
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-53. PMID 18388924 DOI: 10.1038/mt.2008.39  1
2008 Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene delivery to the nervous system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 640-6. PMID 18362921 DOI: 10.1038/mt.2008.42  1
2008 Vangeison G, Carr D, Federoff HJ, Rempe DA. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1988-93. PMID 18287515 DOI: 10.1523/JNEUROSCI.5323-07.2008  1
2008 Lim ST, Lim KC, Giuliano RE, Federoff HJ. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. The Journal of Comparative Neurology. 507: 1228-44. PMID 18181141 DOI: 10.1002/cne.21608  1
2008 Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 481-6. PMID 18180775 DOI: 10.1038/sj.mt.6300387  1
2008 Dekeyser CM, Zuyderhoff E, Giuliano RE, Federoff HJ, Dupont-Gillain ChC, Rouxhet PG. A rough morphology of the adsorbed fibronectin layer favors adhesion of neuronal cells. Journal of Biomedical Materials Research. Part A. 87: 116-28. PMID 18085643 DOI: 10.1002/jbm.a.31739  1
2008 Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. The Journal of Gene Medicine. 10: 152-64. PMID 18058952 DOI: 10.1002/jgm.1130  1
2008 Maguire-Zeiss KA, Mhyre TR, Federoff HJ. Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Experimental Neurology. 209: 101-13. PMID 18035353 DOI: 10.1016/j.expneurol.2007.09.030  1
2008 Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunology, Immunotherapy : Cii. 57: 663-75. PMID 17952436 DOI: 10.1007/s00262-007-0405-1  1
2008 Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. Synuclein activates microglia in a model of Parkinson's disease. Neurobiology of Aging. 29: 1690-701. PMID 17537546 DOI: 10.1016/j.neurobiolaging.2007.04.006  1
2008 Mhyre TR, Loy R, Tariot PN, Profenno LA, Maguire-Zeiss KA, Zhang D, Coleman PD, Federoff HJ. Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. Neurobiology of Aging. 29: 1631-43. PMID 17521776 DOI: 10.1016/j.neurobiolaging.2007.04.004  1
2008 Miller RM, Federoff HJ. Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiology of Aging. 29: 71-7. PMID 17101197 DOI: 10.1016/j.neurobiolaging.2006.09.006  1
2008 Maguire-Zeiss KA, Su X, Federoff HJ. Microglial activation in a mouse model of α-synuclein overexpression Parkinson's Disease. 545-557. DOI: 10.1016/B978-0-12-374028-1.00040-3  1
2008 Bowers WJ, Janelsins MC, Federoff HJ. Gene therapy and vaccination Neuroimmune Pharmacology. 709-724. DOI: 10.1007/978-0-387-72573-4_48  1
2007 Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Research. 67: 10027-37. PMID 17942937 DOI: 10.1158/0008-5472.CAN-06-2391  1
2007 Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 25: 7410-21. PMID 17868958 DOI: 10.1016/j.vaccine.2007.08.015  1
2007 Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ. Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochemical and Biophysical Research Communications. 361: 599-604. PMID 17673176 DOI: 10.1016/j.bbrc.2007.07.039  1
2007 Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1848-55. PMID 17653102 DOI: 10.1038/sj.mt.6300267  1
2007 Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD, Pearce DA. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Research. 1162: 98-112. PMID 17617387 DOI: 10.1016/j.brainres.2007.05.018  1
2007 Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. Journal of Virological Methods. 145: 37-46. PMID 17606303 DOI: 10.1016/j.jviromet.2007.05.013  1
2007 Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. The Journal of Biological Chemistry. 282: 16187-201. PMID 17420250 DOI: 10.1074/jbc.M702203200  1
2007 Ryan DA, Federoff HJ. Translational considerations for CNS gene therapy. Expert Opinion On Biological Therapy. 7: 305-18. PMID 17309323 DOI: 10.1517/14712598.7.3.305  1
2007 Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human Gene Therapy. 18: 93-105. PMID 17298238 DOI: 10.1089/hum.2006.082  1
2007 Federoff HJ, Mhyre TR. Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Neuron. 53: 315-7. PMID 17270727 DOI: 10.1016/j.neuron.2007.01.013  1
2007 Miller RM, Kiser GL, Kaysser-Kranich T, Casaceli C, Colla E, Lee MK, Palaniappan C, Federoff HJ. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Experimental Neurology. 204: 421-32. PMID 17254569 DOI: 10.1016/j.expneurol.2006.12.005  1
2007 Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Research. 1134: 33-44. PMID 17196186 DOI: 10.1016/j.brainres.2006.11.079  1
2007 Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 25: 1634-46. PMID 17145123 DOI: 10.1016/j.vaccine.2006.11.004  1
2007 Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff HJ. VIP is a transcriptional target of Nurr1 in dopaminergic cells. Experimental Neurology. 203: 221-32. PMID 16999955 DOI: 10.1016/j.expneurol.2006.08.005  1
2006 Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. The Journal of Gene Medicine. 8: 1320-8. PMID 16989006 DOI: 10.1002/jgm.972  1
2006 Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff HJ. Identification of human alpha-synuclein specific single chain antibodies. Biochemical and Biophysical Research Communications. 349: 1198-205. PMID 16973126 DOI: 10.1016/j.bbrc.2006.08.127  1
2006 Miller RM, Federoff HJ. Microarrays in Parkinson's disease: a systematic approach. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 319-26. PMID 16815215 DOI: 10.1016/j.nurx.2006.05.008  1
2006 Federoff HJ, Mhyre TR. Systems biology: a primer. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 293-4. PMID 16815212 DOI: 10.1016/j.nurx.2006.05.035  1
2006 Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. HSV amplicons: neuro applications. Current Gene Therapy. 6: 337-50. PMID 16787185 DOI: 10.2174/156652306777592045  1
2006 Tyler CM, Federoff HJ. CNS gene therapy and a nexus of complexity: systems and biology at a crossroads. Cell Transplantation. 15: 267-73. PMID 16719061 DOI: 10.3727/000000006783982007  1
2006 Rempe D, Vangeison G, Hamilton J, Li Y, Jepson M, Federoff HJ. Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis (New York, N.Y. : 2000). 44: 44-9. PMID 16419044 DOI: 10.1002/gene.20183  1
2006 Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 580-8. PMID 16412694 DOI: 10.1016/j.ymthe.2005.11.011  1
2006 Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff HJ, Cooper JD, Pearce DA. Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons. Neurobiology of Disease. 22: 284-93. PMID 16412658 DOI: 10.1016/j.nbd.2005.11.008  1
2006 Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Experimental Neurology. 197: 347-52. PMID 16289170 DOI: 10.1016/j.expneurol.2005.10.008  1
2006 Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff HJ. Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiology of Disease. 21: 305-13. PMID 16143538 DOI: 10.1016/j.nbd.2005.07.010  1
2005 Federoff HJ. Alzheimer's disease: reducing the burden with ApoE2. Gene Therapy. 12: 1019-29. PMID 19202630 DOI: 10.1038/sj.gt.3302522  1
2005 Maguire-Zeiss KA, Federoff HJ. Novel gene therapeutic strategies for neurodegenerative diseases. Ernst Schering Research Foundation Workshop. 147-71. PMID 16315613  1
2005 Federoff HJ, Bowers WJ. Immune shaping and the development of Alzheimer's disease vaccines. Science of Aging Knowledge Environment : Sage Ke. 2005: pe35. PMID 16293586 DOI: 10.1126/sageke.2005.46.pe35  1
2005 Miller RM, Federoff HJ. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 11: 539-49. PMID 16282595 DOI: 10.1177/1073858405278330  1
2005 Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Annals of Surgical Oncology. 12: 1025-36. PMID 16244806 DOI: 10.1245/ASO.2005.03.081  1
2005 Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. Journal of Neuroinflammation. 2: 23. PMID 16232318 DOI: 10.1186/1742-2094-2-23  1
2005 de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff HJ, Stanton PK, Rozental R. Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke; a Journal of Cerebral Circulation. 36: 2232-7. PMID 16179575 DOI: 10.1161/01.STR.0000182239.75969.d8  1
2005 Maguire-Zeiss KA, Short DW, Federoff HJ. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Research. Molecular Brain Research. 134: 18-23. PMID 15790526 DOI: 10.1016/j.molbrainres.2004.09.014  1
2005 Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ. beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Research. Molecular Brain Research. 133: 286-98. PMID 15710246 DOI: 10.1016/j.molbrainres.2004.10.026  1
2005 Miller RM, Chen LL, Kiser GL, Giesler TL, Kaysser-Kranich TM, Palaniappan C, Federoff HJ. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of Aging. 26: 765-75. PMID 15708451 DOI: 10.1016/j.neurobiolaging.2004.12.002  1
2005 Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. Journal of Virology. 79: 2124-32. PMID 15681415 DOI: 10.1128/JVI.79.4.2124-2132.2005  1
2005 Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiology of Aging. 26: 393-407. PMID 15653168 DOI: 10.1016/j.neurobiolaging.2004.04.006  1
2004 Henricksen LA, Federoff HJ. Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism. Journal of Alzheimer's Disease : Jad. 6: S43-6. PMID 15665413  1
2004 Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10963-73. PMID 15574746 DOI: 10.1523/JNEUROSCI.3461-04.2004  1
2004 Maguire-Zeiss KA, Federoff HJ. Safety of viral vectors for neurological gene therapies. Current Opinion in Molecular Therapeutics. 6: 473-81. PMID 15537048  1
2004 Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 8: 812-22; discussion 8. PMID 15531234 DOI: 10.1016/j.gassur.2004.08.007  1
2004 Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff HJ. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7445-54. PMID 15329391 DOI: 10.1523/JNEUROSCI.4204-03.2004  1
2004 Reinblatt M, Pin RH, Federoff HJ, Fong Y. Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases. Annals of Surgery. 239: 892-9; discussion 89. PMID 15166969 DOI: 10.1097/01.sla.0000128308.36393.38  1
2004 Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. Journal of Neurophysiology. 92: 2394-404. PMID 15152019 DOI: 10.1152/jn.00278.2004  1
2004 Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genetics and Cytogenetics. 149: 1-10. PMID 15104276 DOI: 10.1016/S0165-4608(03)00234-6  1
2004 Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ, Ogawa S. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. The Journal of Clinical Investigation. 113: 876-84. PMID 15067320 DOI: 10.1172/JCI19480  1
2003 Lim KC, Lim ST, Federoff HJ. Neurotrophin secretory pathways and synaptic plasticity. Neurobiology of Aging. 24: 1135-45. PMID 14643385 DOI: 10.1016/j.neurobiolaging.2003.09.003  1
2003 Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 790-5. PMID 14599812 DOI: 10.1016/j.ymthe.2003.07.005  1
2003 Kyrkanides S, Miller JH, Federoff HJ. Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. Brain Research. Molecular Brain Research. 119: 1-9. PMID 14597224 DOI: 10.1016/j.molbrainres.2003.08.016  1
2003 Tariot PN, Federoff HJ. Current treatment for Alzheimer disease and future prospects. Alzheimer Disease and Associated Disorders. 17: S105-13. PMID 14512816 DOI: 10.1097/00002093-200307004-00005  1
2003 Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Experimental Neurology. 183: 47-55. PMID 12957487 DOI: 10.1016/S0014-4886(03)00080-3  1
2003 Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7385-94. PMID 12917374  1
2003 Maguire-Zeiss KA, Federoff HJ. Convergent pathobiologic model of Parkinson's disease. Annals of the New York Academy of Sciences. 991: 152-66. PMID 12846984  1
2003 Bowers WJ, Olschowka JA, Federoff HJ. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Therapy. 10: 941-5. PMID 12756414 DOI: 10.1038/sj.gt.3302047  1
2003 Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 21: 2288-97. PMID 12744859 DOI: 10.1016/S0264-410X(03)00099-9  1
2003 Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 218-27. PMID 12597910 DOI: 10.1016/S1525-0016(02)00036-9  1
2003 Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nature Medicine. 9: 231-5. PMID 12539041 DOI: 10.1038/nm821  1
2003 Federoff HJ. GAD Zooks! Excitement to inhibition in one easy step? Gene Therapy. 10: 365-366. DOI: 10.1038/sj.gt.3301964  1
2003 Miller RM, Casaceli C, Chen L, Federoff HJ. Gene expression analysis of the MPTP-lesioned substantia nigra in mice Annals of the New York Academy of Sciences. 991: 315-318.  1
2003 Federoff HJ. Preface Annals of the New York Academy of Sciences. 991: ix.  1
2003 Luo Y, Henricksen LA, Maguire-Zeiss KA, Federoff HJ. Development of Nurr1 stable cell lines for the identification of downstream targets Annals of the New York Academy of Sciences. 991: 354-358.  1
2003 Luo Y, Federoff HJ. Secreted factors from primary midbrain glia regulate Nurr1 activity Annals of the New York Academy of Sciences. 991: 350-353.  1
2002 Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Research. 62: 6545-51. PMID 12438249  1
2002 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. Somatic mosaic approaches and the aging brain. Neurobiology of Aging. 23: 977-84. PMID 12392799 DOI: 10.1016/S0197-4580(02)00077-5  1
2002 Bowers WJ, Federoff HJ. Amyloid immunotherapy-engendered CNS inflammation. Neurobiology of Aging. 23: 675-6; discussion 68. PMID 12392770 DOI: 10.1016/S0197-4580(02)00035-0  1
2002 Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 455-63. PMID 12377186 DOI: 10.1006/mthe.2002.0693  1
2002 Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Annals of Surgery. 236: 337-42; discussion 3. PMID 12192320 DOI: 10.1097/01.SLA.0000026683.20583.EA  1
2002 Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ. Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplantation. 11: 331-49. PMID 12162374  1
2002 Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.). 297: 259-63. PMID 12114629 DOI: 10.1126/science.1072221  1
2002 Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 12-8. PMID 12095298 DOI: 10.1006/mthe.2002.0627  1
2002 Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 723-30. PMID 12027556 DOI: 10.1006/mthe.2002.0609  1
2002 Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Experimental Neurology. 175: 35-48. PMID 12009758 DOI: 10.1006/exnr.2002.7882  1
2002 Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. Journal of Virology. 76: 5565-80. PMID 11991985 DOI: 10.1128/JVI.76.11.5565-5580.2002  1
2002 Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff HJ, Davidson BL. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proceedings of the National Academy of Sciences of the United States of America. 99: 6216-21. PMID 11959904 DOI: 10.1073/pnas.082011999  1
2002 Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 300-6. PMID 11863420 DOI: 10.1006/mthe.2002.0539  1
2002 Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development (Cambridge, England). 129: 467-77. PMID 11807038  1
2001 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. HSV vector-mediated gene delivery to the central nervous system. Current Opinion in Molecular Therapeutics. 3: 482-90. PMID 11699893  1
2001 Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Human Gene Therapy. 12: 1867-79. PMID 11589829 DOI: 10.1089/104303401753153929  1
2001 DeCory HH, Piech-Dumas KM, Sheu SS, Federoff HJ, Anders MW. Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1256-62. PMID 11560867  1
2001 Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 250-6. PMID 11545616 DOI: 10.1006/mthe.2001.0448  1
2001 Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 31: 353-65. PMID 11516394 DOI: 10.1016/S0896-6273(01)00371-3  1
2001 Petrowsky H, Roberts GD, Kooby DA, Burt BM, Bennett JJ, Delman KA, Stanziale SF, Delohery TM, Tong WP, Federoff HJ, Fong Y. Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. Journal of Virology. 75: 7050-8. PMID 11435585 DOI: 10.1128/JVI.75.15.7050-7058.2001  1
2001 Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 98: 287-95. PMID 11435295 DOI: 10.1182/blood.V98.2.287  1
2001 Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 958-63. PMID 11407910 DOI: 10.1006/mthe.2001.0334  1
2001 Cozzi PJ, Malhotra S, McAuliffe P, Kooby DA, Federoff HJ, Huryk B, Johnson P, Scardino PT, Heston WD, Fong Y. Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1306-8. PMID 11344122  1
2001 Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Therapy. 8: 111-20. PMID 11313780 DOI: 10.1038/sj.gt.3301340  1
2001 Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410: 89-93. PMID 11242047 DOI: 10.1038/35065091  1
2001 Brooks AD, Ng B, Liu D, Brownlee M, Burt M, Federoff HJ, Fong Y. Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. Surgery. 129: 324-34. PMID 11231461 DOI: 10.1067/msy.2001.111697  1
2001 Bowers WJ, Maguire-Zeiss KA, Harvey BK, Federoff HJ. Gene therapeutic approaches to the treatment of Parkinson's disease Clinical Neuroscience Research. 1: 483-495. DOI: 10.1016/S1566-2772(01)00026-3  1
2000 Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Human Gene Therapy. 11: 2341-52. PMID 11096439 DOI: 10.1089/104303400750038453  1
2000 Brooks AI, Cory-Slechta DA, Federoff HJ. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 13378-83. PMID 11078505 DOI: 10.1073/pnas.230169397  1
2000 Brooks AI, Cory-Slechta DA, Murg SL, Federoff HJ. Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory. Neurobiology of Learning and Memory. 74: 241-58. PMID 11031130 DOI: 10.1006/nlme.1999.3951  1
2000 Telfeian AE, Federoff HJ, Leone P, During MJ, Williamson A. Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro. Neurobiology of Disease. 7: 362-74. PMID 10964607 DOI: 10.1006/nbdi.2000.0294  1
2000 Bowers WJ, Howard DF, Federoff HJ. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 294-9. PMID 10933945 DOI: 10.1006/mthe.2000.0039  1
1999 Van de Water TR, Staecker H, Halterman MW, Federoff HJ. Gene therapy in the inner ear. Mechanisms and clinical implications. Annals of the New York Academy of Sciences. 884: 345-60. PMID 10842605  1
1999 Federoff HJ. Novel targets for CNS gene therapy. Gene Therapy. 6: 1907-8. PMID 10637440 DOI: 10.1038/sj.gt.3301074  1
1999 Federoff HJ. An infectious conspiracy: the case for HSV-1 and APOEepsilon4 in Alzheimer's disease. Neurobiology of Aging. 20: 467-8. PMID 10604442 DOI: 10.1016/S0197-4580(99)00070-6  1
1999 Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Experimental Neurology. 159: 65-72. PMID 10486175 DOI: 10.1006/exnr.1999.7160  1
1999 Lee JH, Federoff HJ, Schoeniger LO. G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 3: 127-31; discussion 1. PMID 10457334  1
1999 Halterman MW, Miller CC, Federoff HJ. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6818-24. PMID 10436039  1
1999 Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1325-34. PMID 10428757  1
1999 Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Human Gene Therapy. 10: 1599-606. PMID 10428205 DOI: 10.1089/10430349950017608  1
1999 Brooks AI, Halterman MW, Federoff HJ. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 10: 337-44. PMID 10203332  1
1999 Antonawich FJ, Federoff HJ, Davis JN. BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Experimental Neurology. 156: 130-7. PMID 10192784 DOI: 10.1006/exnr.1998.7004  1
1999 Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff HJ. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Research. 823: 1-10. PMID 10095006 DOI: 10.1016/S0006-8993(98)01192-5  1
1999 Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 93: 643-54. PMID 9885227  1
1998 Federoff HJ, Atkinson M. Towards gene therapy of neurodegenerative disease. Progress in Brain Research. 117: 503-10. PMID 9932428  1
1998 Heath BM, Xia J, Dong E, An RH, Brooks A, Liang C, Federoff HJ, Kass RS. Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse. The Journal of Physiology. 512: 779-91. PMID 9769421 DOI: 10.1111/j.1469-7793.1998.779bd.x  1
1998 Deng SX, Panahian N, James H, Gelbard HA, Federoff HJ, Dewhurst S, Epstein LG. Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption. Journal of Neuroscience Methods. 83: 159-64. PMID 9765129 DOI: 10.1016/S0165-0270(98)00077-6  1
1998 Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ. Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. Journal of Neuroscience Methods. 80: 137-47. PMID 9667386 DOI: 10.1016/S0165-0270(97)00207-0  1
1998 Scriabine A, Gordis E, Silva AJ, Federoff HJ, Limbird LE. Application of gene knockout technique to alcohol research. Satellite symposium to the 28(th) annual meeting of the society for neuroscience. Los Angeles, CA, November 7, 1998 Cns Drug Reviews. 4: 398-400.  1
1997 Federoff HJ, Halterman MW, Brooks AI. Use of the herpes amplicon system as a vehicle for somatic gene transfer. Advanced Drug Delivery Reviews. 27: 29-39. PMID 10837549 DOI: 10.1016/S0169-409X(97)00020-3  1
1997 Lu B, Federoff HJ, Wang Y, Goldsmith LA, Scott G. Topical application of viral vectors for epidermal gene transfer. The Journal of Investigative Dermatology. 108: 803-8. PMID 9129236  1
1997 Bowers WJ, Howard DF, Federoff HJ. Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Experimental Neurology. 144: 58-68. PMID 9126153 DOI: 10.1006/exnr.1996.6389  1
1997 Federoff HJ, Brooks A, Muhkerjee B, Corden T. Somatic gene transfer approaches to manipulate neural networks. Journal of Neuroscience Methods. 71: 133-42. PMID 9125382 DOI: 10.1016/S0165-0270(96)00133-1  1
1997 Brooks AI, Muhkerjee B, Panahian N, Cory-Slechta D, Federoff HJ. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nature Biotechnology. 15: 57-62. PMID 9035107 DOI: 10.1038/nbt0197-57  1
1997 Halterman MW, Federoff HJ. Molecular Modification of Neural Networks: Altering Synaptic Function Through the use of Viral Mediated Gene Transfer Advances in Organ Biology. 2: 113-135. DOI: 10.1016/S1569-2590(08)60183-4  1
1996 Tung C, Federoff HJ, Brownlee M, Karpoff H, Weigel T, Brennan MF, Fong Y. Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production. Human Gene Therapy. 7: 2217-24. PMID 8953312 DOI: 10.1089/hum.1996.7.18-2217  1
1996 Jin BK, Belloni M, Conti B, Federoff HJ, Starr R, Son JH, Baker H, Joh TH. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Human Gene Therapy. 7: 2015-24. PMID 8930662 DOI: 10.1089/hum.1996.7.16-2015  1
1996 Geschwind MD, Hartnick CJ, Liu W, Amat J, Van De Water TR, Federoff HJ. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. Human Gene Therapy. 7: 173-82. PMID 8788168 DOI: 10.1089/hum.1996.7.2-173  1
1996 Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and Cellular Neurosciences. 7: 222-38. PMID 8726105 DOI: 10.1006/mcne.1996.0017  1
1995 Hammes HP, Federoff HJ, Brownlee M. Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Molecular Medicine (Cambridge, Mass.). 1: 527-34. PMID 8529118  1
1995 Andrade-Rozental AF, Rozental R, Hassankhani A, Spray DC, Federoff HJ. Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice. Developmental Biology. 169: 533-46. PMID 7781897 DOI: 10.1006/dbio.1995.1167  1
1995 Casaccia-Bonnefil P, Stelzer A, Federoff HJ, Bergold PJ. A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit. Neuroscience Letters. 191: 67-70. PMID 7659294 DOI: 10.1016/0304-3940(95)11560-8  1
1995 Fong Y, Federoff HJ, Brownlee M, Blumberg D, Blumgart LH, Brennan MF. Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors. Hepatology (Baltimore, Md.). 22: 723-9. PMID 7657275 DOI: 10.1016/0270-9139(95)90289-9  1
1995 Linnik MD, Zahos P, Geschwind MD, Federoff HJ. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke; a Journal of Cerebral Circulation. 26: 1670-4; discussion 1. PMID 7544927  1
1995 Mesri EA, Federoff HJ, Brownlee M. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circulation Research. 76: 161-7. PMID 7530606  1
1994 Bohn MC, Lin Q, Federoff HJ. Stimulation of neurite growth rat adrenal chromaffin cells infected with a defective herpes simplex virus carrying an NGF minigene. Gene Therapy. 1: S70. PMID 8542416  1
1994 Geschwind MD, Kessler JA, Geller AI, Federoff HJ. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Brain Research. Molecular Brain Research. 24: 327-35. PMID 7968372 DOI: 10.1016/0169-328X(94)90146-5  1
1993 Federoff HJ, Lawrence D, Brownlee M. Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth. Diabetes. 42: 509-13. PMID 8454100  1
1993 Bergold PJ, Casaccia-Bonnefil P, Zeng XL, Federoff HJ. Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 6165-9. PMID 8392189  1
1993 Lustig RH, Hua P, Wilson MC, Federoff HJ. Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain. Brain Research. Molecular Brain Research. 20: 101-10. PMID 8255171 DOI: 10.1016/0169-328X(93)90114-5  1
1993 Casaccia-Bonnefil P, Benedikz E, Shen H, Stelzer A, Edelstein D, Geschwind M, Brownlee M, Federoff HJ, Bergold PJ. Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices. Journal of Neuroscience Methods. 50: 341-51. PMID 8152244 DOI: 10.1016/0165-0270(93)90040-X  1
1992 Federoff HJ, Geschwind MD, Geller AI, Kessler JA. Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia. Proceedings of the National Academy of Sciences of the United States of America. 89: 1636-40. PMID 1311846  1
1990 Biller BM, Federoff HJ, Koenig JI, Klibanski A. Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea. The Journal of Clinical Endocrinology and Metabolism. 70: 311-7. PMID 2153693 DOI: 10.1210/jcem-70-2-311  1
1983 Federoff HJ, Eccleshall TR, Marmur J. Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis. Journal of Bacteriology. 156: 301-7. PMID 6352680  1
1983 Federoff HJ, Eccleshall TR, Marmur J. Regulation of maltase synthesis in Saccharomyces carlsbergensis. Journal of Bacteriology. 154: 1301-8. PMID 6343348  1
1982 Federoff HJ, Cohen JD, Eccleshall TR, Needleman RB, Buchferer BA, Giacalone J, Marmur J. Isolation of a maltase structural gene from Saccharomyces carlsbergensis. Journal of Bacteriology. 149: 1064-70. PMID 7037739  1
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